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299 results on '"Kubo, Tateki"'

11. Laparoscopically assisted diaphragmatic hernia repair with mesh and a myocutaneous flap after left ventricular assist device explantation: A case report.

Author

Kawabata, Kota, Takahashi, Tsuyoshi, Funaki, Soichiro, Maeda, Daisuke, Nakajima, Kiyokazu, Kurokawa, Yukinori, Yamamoto, Kazuyoshi, Saito, Takuro, Momose, Kota, Yamashita, Kotaro, Tanaka, Koji, Makino, Tomoki, Kubo, Tateki, Shintani, Yasushi, Eguchi, Hidetoshi, and Doki, Yuichiro

Subjects
HEART assist devices, HERNIA surgery, MUSCULOCUTANEOUS flaps, DIAPHRAGMATIC hernia, RECTUS abdominis muscles
Abstract

We report the case of a 32‐year‐old man who developed a giant diaphragmatic hernia following the removal of a left ventricular assist device 4 years prior due to improved cardiac function. Chest radiography revealed an intrathoracic prolapse of the gastrointestinal tract. The patient was diagnosed with a diaphragmatic hernia and a laparoscopy‐assisted repair was performed. A 12 × 8 cm hernia was found intraoperatively on the left diaphragm, and a large portion of the gastrointestinal tract had prolapsed into the thoracic cavity. We attempted to repair the ventromedial defect using mesh; however, it was found to be insufficient. Therefore, we used a left rectus abdominis myocutaneous flap to fill the defect and sutured it to the mesh. A myocutaneous flap could be a useful strategy in cases where complete closure with mesh is difficult. [ABSTRACT FROM AUTHOR]

Published
2024
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32. Altered actin dynamics is possibly implicated in the inhibition of mechanical stimulation‐induced dermal fibroblast differentiation into myofibroblasts.

Author

Kuroda, Kazuya, Kiya, Koichiro, Matsuzaki, Shinsuke, Takamura, Hironori, Otani, Naoya, Tomita, Koichi, Kawai, Kenichiro, Fujiwara, Toshihiro, Nakai, Kunihiro, Onishi, Ayako, Katayama, Taiichi, and Kubo, Tateki

Subjects
MYOFIBROBLASTS, FIBROBLASTS, ACTIN, HYPERTROPHIC scars, NEUROFIBROMATOSIS 1, KELOIDS, SCARS
Abstract

The formation of hypertrophic scars and keloids is strongly associated with mechanical stimulation, and myofibroblasts are known to play a major role in abnormal scar formation. Wounds in patients with neurofibromatosis type 1 (NF1) become inconspicuous and lack the tendency to form abnormal scars. We hypothesized that there would be a unique response to mechanical stimulation and subsequent scar formation in NF1. To test this hypothesis, we investigated the molecular mechanisms of differentiation into myofibroblasts in NF1‐derived fibroblasts and neurofibromin‐depleted fibroblasts and examined actin dynamics, which is involved in fibroblast differentiation, with a focus on the pathway linking LIMK2/cofilin to actin dynamics. In normal fibroblasts, expression of α‐smooth muscle actin (α‐SMA), a marker of myofibroblasts, significantly increased after mechanical stimulation, whereas in NF1‐derived and neurofibromin‐depleted fibroblasts, α‐SMA expression did not change. Phosphorylation of cofilin and subsequent actin polymerization did not increase in NF1‐derived and neurofibromin‐depleted fibroblasts after mechanical stimulation. Finally, in normal fibroblasts treated with Jasplakinolide, an actin stabilizer, α‐SMA expression did not change after mechanical stimulation. Therefore, when neurofibromin was dysfunctional or depleted, subsequent actin polymerization did not occur in response to mechanical stimulation, which may have led to the unchanged expression of α‐SMA. We believe this molecular pathway can be a potential therapeutic target for the treatment of abnormal scars. [ABSTRACT FROM AUTHOR]

Published
2023
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