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1,180 results on '"Krause, K."'

1. Combining one-session treatment with a homework program including app-based technology to enhance the treatment of childhood specific phobias: A study protocol of a multicenter pragmatic randomized controlled trial

Author

Klein, A.M., Hagen, A., Rahemenia, J., de Gier, E., Rapee, R.M., Nauta, M., de Bruin, E., Biesters, J., van Rijswijk, L., Bexkens, A., Baartmans, J.M.D., Mobach, L., Zimmermann, R., Krause, K., Bögels, S.M., Ollendick, T.H., and Schneider, S.

Published
2024
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8. PW02-040 - Low-penetrance NLRP3 variants

Author

Endres, T, Hofer, F, Goldbach-Mansky, R, Hoffman, HM, Blank, N, Krause, K, Rietschel, C, Horneff, G, Lohse, P, and Kuemmerle-Deschner, J

Published
2013

21. Discovery of NOX3 inhibitors for the prevention of acquired hearing loss.

Author

Oberhauser, L., Rousset, F., Daskalou, D., Cambet, Y., Sgroi, S., Krause, K. -H., Jaquet, V., and Senn, P.

Subjects
CONFERENCES & conventions, OXIDOREDUCTASES, HEARING disorders
Abstract

The accumulation of reactive oxygen species (ROS) in cells and tissues contributes to the development and the progression of numerous diseases such as cancers, metabolic syndromes, or sensorineural disorders. NAPDH oxidases, a family of enzymes which sole function is to produce reactive oxygen species (ROS), appeared as relevant therapeutic targets in the treatment of oxidant-mediated pathologies. More specifically, the NOX3 isoform is only expressed in the inner ear and, although its physiological role in the cochlea is not known, there is increasing evidence that NOX3 is involved in different forms of acquired hearing loss. Thus, the inhibition of NOX3 would provide an efficient otoprotec-tive strategy, notably by preventing ROS-induced damages to the auditory synapse. This project aims at discovering NOX3 small molecule inhibitors for the prevention of acquired sensorineural hearing loss. We developed a cell-based high-throughput screen using an inducible system allowing the expression of NOX3 upon 24 h treatment with tetracy-cline. NOX3 activity was assessed through the detection of generated extracellular superoxide radical anion (O2*-) using the colorimetric assay WST-1. The non-specific NOX inhibitor diphenyleneiodonium chloride (DPI) was used as a reference compound for maximal inhibition. Among the 15,511 compounds screened, 115 showed an inhibitory activity on NOX3 equal to or higher than 50% and were considered as hits. These hits were further tested in dose-response using WST-1 and validated using orthogonal assays detecting hydrogen peroxide (Amplex Red/HRP and CBA fluorometric assays) and cytotoxicity. The specificity of the validated hits for NOX3 over the 6 other isoforms was also assessed. This critical early drug discovery step paves the way to the development of new small molecule therapeutics for the prevention of sensorineural hearing loss. [ABSTRACT FROM AUTHOR]

Published
2024

23. Efficacy of a Medical Directive to Reduce Inappropriate Indwelling Urinary Catheter Use on Orthopedic Wards

Author

Jina, R., Foley, L., Chan, S., Wong, E., Ward, S., Kuan, D., Wong, C., Wang, S-J., Lee, L., Hammond, M., Leu, R., Cuperfain, A., Perrella, A., Canfield, A., Woo, T., McCollum, A., Landry, V., Yetman, L., Theou, O., Andrew, M., Jarrett, P., Arya, R., Cristancho, S., Thain, J., Diachun, L., Tsui, C., Kim, K., Spencer, M., Reich, K., Moledina, A., Kwan, E., Keir, M., Fan, B.J.Y., Wong, R.Y.M., Reppas-Rindlisbacher, C., Lee, J., Siddhpuria, S., Gabor, C., De Freitas, S., Khalili, Y., Curkovic, A., Patterson, C., Naqvi, R., Wong, C.L., Koo, K., To, E., Stoian, M., Tung, J., Benjamin, S., Ho, J., Burrell, A., Chahine, S., Casey, G., Kekewich, M., Swain, K., Pridham, A., Morgan, A., Wilding, L., Moors, J., Khoury, L., Jabbar, A., Costa, A., Jafri, A., Osborne, A., Cowan, D., Onge, J. St., Pieruccini-Faria, F., Bray, N., Montero-Odasso, M., Abou-Sharkh, A., Mayo, N., Wall, M., Harvey, E., St-Jean, S., Albers, A., Bergeron, S., Bérubé, P., Morin, S., Turner, J., Martin, P., Zhang, Y.Z., Tannenbaum, C., Pulok, M., van der Valk, A., Rockwood, K., Dearing, M., Bowles, S., Isenor, J., Reeve, E., Piankova, P., Eintracht, S., Hoffer, L.J., Afilalo, J., Mate, K., Morais, J., Ahmed, U., Akter, R., Maksymowych, W., Martin, L., Hogan, D., Alston, J., Gandell, D., Cheung, E., Arora, R., Kundid, E., Ali, A., Martin, G., Versloot, J., Bartholomew, S., Robitaille, C., Plebon-Huff, S., Beauchet, O., Fung, S., Launay, C., Chabot, J., Galery, K., Dejager, S., Bineau, S., Berrut, G., Bobrowski, C., Brown, D., Contreras, J., Norris, M., Jaunkalns, R., Liu, B., Chertkow, H., Borrie, M., Feldman, H., Whitehead, V., Rylett, J., McGilton, K., Black, S., Masellis, M., Chuen, V., Chan, A., Alibhai, S., Chau, V., Church, S., Rogers, E., Squires, E., Colborne, A., Fenwick, P., Cahill, L., Collier-Jarvis, Krista, Mah, Jasmine, Cullen, S., Carroll, S., Cuthbertson, L.R., Stajduhar, K., Cloutier, D., Day, A., Ng, K., Dubé, J., Truemner, J., Best, S., Sargeant, P., Faisal, S., Ivo, J., McDougall, A., Bauer, J., Pritchard, S., Chang, F., Patel, T., Faulkner, C., Bronskill, S., Rosella, L., Stall, N., Savage, R., Zhu, L., Manuel, D., Rochon, P., Godin, J., Black, K., McNeil, S.A., Andrew, M.K., Gong, Z., Song, H., Thrall, S., Wang, X.M., Allaby, C., Papaioannou, A., Gorman, M., MacGrath, M., Haddad, S.M. Hassan, Scott, C.J.M., Arnott, S.R., Ozzoude, M., Swartz, R.H., Mandzia, J., Kwan, D., Beaton, D., Bartha, R., Harasym, P., Brisbin, S., Quail, P.B., Venturato, L., Sinnarajah, A., Virk, N., Kaasalainen, S., Sussman, T., Hanson, H., Sharon, S., Holroyd-Leduc, J., Haslam, L., DePaul, V., Woo, K., Donnelly, C., Auais, M., Haviva, C., Zimmer, Z., Jacob, K., Sonjak, V., Hajj, G., Chevalier, S., Lamarche, M., Janower, A., John, P. St., Jayanama, K., Jeffrey, E., Ji, A. (Tianshu), McGregor, M., Kow, J., Kehler, S., Giacomantonio, N., Firth, W., Blanchard, C., Kelly, S., Lorbergs, A., Crilly, R., Knoefel, F., Sabra, I., Wallace, B., Breau, M., Sweet, L., Goubran, R., Frank, A., Kokorelias, K., Cronin, S., Eftekhar, P., Munce, S., Jagal, S., Vellani, S., Wang, C., Salbach, N., Colella, T., Kontos, P., Grigorovich, A., Chau, B., Cameron, J., Krause, K., Lam, K., Arnold, C., Wu, W., Piggott, K., Parikh, R., Hillier, L.M., Lu, S.K., Gevaert, V., Walker, S., Lu, S., Wong, W., Gregg, S., Bedirian, W., Skimson, K., Milligan, J., Lovett, M., Negm, A., Ioannidis, G., Petruccelli, D., Winemaker, M., Luthra, A.S., de Jesus, I.T. Machado, Gratão, A.C. Martins, Nascimento, C.M. Crispim, de Souza Orlandi, F., de Oliveira Gomes, G.A., Say, K. Gramani, dos Santos, A. Angelini, Cominetti, M.R., Pavarini, S.C. Iost, Zazzetta, M.S., Madden, Ken, Feldman, Boris, Meneilly, Graydon, Makhani, A., Qureshi, S., Hunter, K.F., Wagg, A., Gibson, W., Marion, M., Monor, A., Malik, S., O’Donoghue, C., Marr, S., Wilson, J. McKinnon, Doleweerd, J., Berezny, T., Mayo, A., Senechal, M., Boudreau, J., Belanger, M., Bouchard, D., McGarrigle, L., Wallace, L., Howlett, S.E., Mehta, N., Ghuman, I., Mehta, M., Brode, S., Mehrabi, M., Marras, T., Mele, B., Merrikh, D., Ismail, Z., Goodarzi, Z., Mercer, S., Babb, K., Nauth, S., Tait, G., Liberman, D., Devine, L., Nepal, R.M., Vojicic, J., Dion, S., Major, M., Isturiz, R.E., Nguyen, Q. Dinh, Nicholson, K., Fortin, M., Griffith, L., Terry, A., Williamson, T., Mangin, D., Stranges, S., Pageau, F., van der Horst, M-L., McArthur, C., Jain, R., Jaglal, S., Adachi, J.D., Giangregorio, L., Parmar, J., Brémault-Phillips, S., Duggleby, W., Charles, L., Tian, P.G. Jaminal, Bedaba, R., Rolfson, D., Torti, J., Dobbs, B., Khera, S., Abbasi, M., Chan, K., Carr, F., Triscott, J., Huang, J., Moores, D., Cerna, J., Jamieson, J., Jensen, L., Johnson, C., Chow, J., Guzak, J., Mathura, P., Sun, X., Pearce, P., Dempsey, E., Mahon, A., Pérez-Zepeda, U., Borda, M-G., Almeda-Valdés, P., Cesari, M., Peters, M-L., Davidson, S., Reece, K., Spira, N., Uranis, C., Whelan, L., Ryan, D.P., Brown, D.M., Saha, A., Thiyagalingam, S., Wachtel, J., Ramasamy, D., Schmidt, K., Nobleza, S., Gordon, C., Hung, M., Thangaraja, M., Searle, S.D., Ellis, H. Logan, Ramlakhan, D., Davis, D., Sekhon, H., Sepehri, K., Song, X., Chinda, B., Braley, M., Zou, M., Tang, B., Garm, A., Park, G., Sirisegaram, L., Sarquis-Adamson, Y., Smallbone, J., Posner, A., Yogaparan, T., Kelly, R., Singh, S., Keetch, K., Heiazi, S., Sandercock, J., Shyr, C., D’Arcy, R., McDermid, R., Clarke, B., Hanson, C., Tate, R., Shah, N., Resnick, J., Amin, S., Manzoor, S., Mistry, N., Fless, K., Rezai, F., Ovnanian, V., Yodice, P., Torbiak, L., Schmaltz, H., Trenaman, S., Kirkland, S., Bodkin, R. J., Wang, K., Ganesh, V., Neat, C., Raber, C., An, H., Beyzaei, N., Lau, C., Lee, F., Cox, L., McElhaney, J., McNeil, S., Wong, T., McKellar, L., Dasgupta, M., Vasudev, A., Burhan, A., O’Regan, N., Yeung, C., Srinathan, S., and Dhaliwal, R.

Subjects
Abstracts, Geriatrics and Gerontology, Gerontology
Published
2019

24. Broadening the infection prevention and control network globally; 2017 Geneva IPC-think tank (part 3)

Author

Zingg, W, Storr, J, Park, BJ, Jernigan, JA, Harbarth, S, Grayson, ML, Tacconelli, E, Allegranzi, B, Cardo, D, Pittet, D, Abbas, M, Ahmad, R, Ailegranzi, B, Andremont, A, Bell, M, Borg, M, Carmeli, Y, Castro-Sanchez, E, Conly, J, Eggimann, P, Gastmeier, P, Hernandez, M, Hetwaldt, L, Holmes, A, Kilpatrick, C, Kolwaite, A, Krause, K-H, Larson, E, Masson-Roy, S, Mehtar, S, Mendelson, M, Lin, LM, Moldovan, A, Monnet, D, Ndoye, B, Nthumba, P, Ogunsola, F, Park, B, Perencevich, E, Samore, M, Seto, WH, Srinivasan, A, Tarrant, C, Tomczyk, S, Talaat, M, Villegas, MV, Voss, A, Walsh, T, Widmer, A, 2017 Geneva-IPC Think Tank, Abbas, M., Ahmad, R., Allegranzi, B., Andremont, A., Bell, M., Borg, M., Cardo, D., Carmeli, Y., Castro-Sanchez, E., Conly, J., Eggimann, P., Gastmeier, P., Grayson, M.L., Harbarth, S., Hernandez, M., Herwaldt, L., Holmes, A., Jernigan, J.A., Kilpatrick, C., Kolwaite, A., Krause, K.H., Larson, E., Masson-Roy, S., Mehtar, S., Mendelson, M., Lin, L.M., Moldovan, A., Monnet, D., Ndoye, B., Nthumba, P., Ogunsola, F., Park, B., Perencevich, E., Pittet, D., Samore, M., Seto, W.H., Srinivasan, A., Storr, J., Tacconelli, E., Tarrant, C., Tomczyk, S., Talaat, M., Villegas, M.V., Voss, A., Walsh, T., Widmer, A., Zingg, W., Abbas, Mohamed, Conly, John, Eggimann, Philippe, Krause, Karl-Heinz, Moldovan, Andréea Anamaria, Monnet, Dominique Ndiouga, Ndoye, Babacar, Tomczyk, Sara Marie, Widmer, Andréas, NIHR knowledge mobilisation fellowship, and National Institute for Health Research

Subjects
0301 basic medicine, Biomedical Research, Global Health, Antimicrobial Stewardship, WHO, 0302 clinical medicine, ECDC, Drug Resistance, Multiple, Bacterial, Infection control, Antimicrobial stewardship, Hand Hygiene, Pharmacology (medical), 030212 general & internal medicine, Pharmacology & Pharmacy, Intersectoral Collaboration, health care economics and organizations, Public, Environmental & Occupational Health, ddc:616, Cross Infection, Public relations, National, Institutional, Anti-Bacterial Agents, Infectious Diseases, International, Public Health, Life Sciences & Biomedicine, Switzerland, Microbiology (medical), medicine.medical_specialty, Infection prevention and control, 030106 microbiology, Control (management), 2017 Geneva-IPC Think Tank, Change, World Health Organization, Microbiology, lcsh:Infectious and parasitic diseases, 03 medical and health sciences, Patient safety, CDC, Collaboration, Networks, parasitic diseases, Control network, medicine, Humans, lcsh:RC109-216, cardiovascular diseases, Infection Control, Science & Technology, business.industry, Public health, Research, Public Health, Environmental and Occupational Health, International health, United States, Group Processes, QR, Stewardship, Centers for Disease Control and Prevention, U.S, business, RA
Abstract

Background Healthcare-associated infection (HAI) is a major challenge for patient safety worldwide, and is further complicated by antimicrobial resistance (AMR) due to excessive antimicrobial use in both humans and animals. Existing infection prevention and control (IPC) networks must be strengthened and adapted to better address the global challenges presented by emerging AMR. Methods In June 2017, 42 international experts convened in Geneva, Switzerland, to discuss two key areas for strengthening the global IPC network: 1) broadening collaboration in IPC; and 2) how to bring the fields IPC and AMR control together. Results The US Centers for Disease Prevention and Control, the European Centre for Disease Prevention and Control, and the World Health Organization (WHO) convened together with international experts to discuss collaboration and networks, demonstrating the participating organizations’ commitment to close collaboration in IPC. The challenge of emerging AMR can only be addressed by strengthening this collaboration across international organisations and between public health and academia. The WHO SAVE LIVES: Clean Your Hands initiative is an example of a successful collaboration between multiple global stakeholders including academia and international public health organisations; it can be used as a model. IPC-strategies are included within the four pillars to combat AMR: surveillance, IPC, antimicrobial and diagnostic stewardship, research and development. The prevention of transmission of multidrug-resistant microorganisms is a patient safety issue, and must be strengthened in the fight against AMR. Conclusions The working group determined that international organisations should take the lead in creating new networks, which will in turn attract academia and other stakeholders to join. At the same time, they should invest in bringing existing IPC and AMR networks under one umbrella. Transmission of multidrug-resistant microorganisms in hospitals and in the community threatens the success of antimicrobial stewardship programmes, and thus, research and development in IPC should be addressed as an enhanced global priority.

Published
2019

27. Increasing dissolved organic carbon concentrations in freshwaters: what is the actual driver?

Author

Sucker C and Krause K

Subjects
Dissolved organic carbon, Atmospheric deposition, Freshwater, Climate change, Forestry, SD1-669.5
Abstract

Since the beginning of the 1990s, an increase in dissolved organic carbon (DOC) has been observed in rivers and lakes in various parts of Europe and North America. The processes responsible for the increased DOC concentrations are complex and not entirely understood. The aim of this review is to provide an overview of the recent debate about increases in the DOC concentrations in surface water and their possible drivers.

Published
2010
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29. Autoimmune Chronic Spontaneous Urticaria Detection with IgG Anti-TPO and Total IgE

Author

Kolkhir, P., Kovalkova, E., Chernov, A., Danilycheva, I., Krause, K., Sauer, M., Shulzhenko, A., Fomina, D., Maurer, M., and Publica

Abstract

Background: Autoimmune chronic spontaneous urticaria (aiCSU) comes with high disease activity and poor response to treatment. Recently, elevated levels of IgG anti-thyroid peroxidase (aTPO) and low levels of total IgE were reported to be common in aiCSU. Objective: To investigate how high aTPO and low IgE individually and combined are linked to features of aiCSU, including treatment responses. Methods: We analyzed records of patients with CSU from 2 independent cohorts (n = 1120) for demographic, clinical, and laboratory parameters and treatment responses. Total IgE and aTPO were measured, and 4 markers of aiCSU were analyzed: autologous serum skin test, basophil activation test (BAT), and blood eosinophil and basophil counts. Cutoff values were greater than or equal to 34 kU/L (high aTPO) and less than 40 IU/mL (low total IgE). Results: One of 10 patients with CSU had both high aTPO and low IgE (aTPOUPIgEDN, 11%, n = 123). aTPOUPIgEDN was linked to higher age at CSU onset, being female, angioedema, and shorter CSU duration. aTPOUPIgEDN was associated with markers of aiCSU, that is, BAT and autologous serum skin test positivity, basopenia, and eosinopenia (P < .01 for all). Almost half the patients with aTPOUPIgEDN (44%, 19 of 43) had a positive BAT result, the best single marker for aiCSU, versus 12% (43 of 344) of patients without aTPOUPIgEDN (P < .001). Relative risk of showing BAT positivity for a patient with aTPOUPIgEDN is 3.636 (95% CI, 2.382-5.551). Patients with aTPOUPIgEDN showed low response rates to antihistamine treatment as compared with patients without aTPOUPIgEDN (30% vs 47%; P = .01). Conclusions: Our findings suggest that aTPOUPIgEDN is a useful diagnostic marker for aiCSU in everyday clinical practice.

Published
2021

38. Learning in Collaborative Moments: Practising Relating Differently with Dementia in Dialogue Meetings

Author

Hoppe, S., Vermeulen, L., Driessen, A., Roding, E., de Groot, M., Krause, K., Anthropology of Health, Care and the Body (AISSR, FMG), and Health, care and the body (ASSR, FMG)

Abstract

In this article, we describe experiences with dialogue evenings within a research collaboration on long-term care and dementia in the Netherlands. What started as a conventional process of ‘reporting back’ to interlocutors transformed over the course of two years into learning and knowing together. We argue that learning took place in three different articulations. First, participants learnt to expand their notion of knowledge. Second, they learnt to relate differently to each other and, therewith, to dementia. And third, participants learnt how to generate knowledge with each other. We further argue that these processes did not happen continuously, but in moments. We suggest that a framework of collaborative moments can be helpful for research projects that are not set up collaboratively from the start. Furthermore, we point to the work required to facilitate these moments.

Published
2019

45. Schnitzler's syndrome: diagnosis, treatment, and follow-up

Author

Simon, A., Asli, B., Braun-Falco, M., De Koning, H., Fermand, J. -P., Grattan, C., Krause, K., Lachmann, H., Lenormand, C., Martinez-Taboada, V., Maurer, M., Peters, M., Rizzi, R., Rongioletti, F., Ruzicka, T., Schnitzler, L., Schubert, B., Sibilia, J., and Lipsker, D.

Published
2013
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