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669 results on '"Kratzsch, Jürgen"'

4. Increase in Serotonin Transporter Binding in Patients With Premenstrual Dysphoric Disorder Across the Menstrual Cycle: A Case-Control Longitudinal Neuroreceptor Ligand Positron Emission Tomography Imaging Study

Author

Sacher, Julia, Zsido, Rachel G., Barth, Claudia, Zientek, Franziska, Rullmann, Michael, Luthardt, Julia, Patt, Marianne, Becker, Georg A., Rusjan, Pablo, Witte, A. Veronica, Regenthal, Ralf, Koushik, Abhay, Kratzsch, Juergen, Decker, Beate, Jogschies, Petra, Villringer, Arno, Hesse, Swen, and Sabri, Osama

Published
2023
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6. Normal Values for the fT3/fT4 Ratio: Centile Charts (0–29 Years) and Their Application for the Differential Diagnosis of Children with Developmental Delay.

Author

Wilpert, Nina-Maria, Thamm, Roma, Thamm, Michael, Kratzsch, Jürgen, Seelow, Dominik, Vogel, Mandy, Krude, Heiko, and Schuelke, Markus

Subjects
CHILDREN with cerebral palsy, CONGENITAL hypothyroidism, MONOCARBOXYLATE transporters, THYROID hormones, YOUNG adults, THYROID hormone receptors
Abstract

Primary congenital hypothyroidism is easily diagnosed on the basis of elevated plasma levels of thyroid-stimulating hormone (TSH). In contrast, in the rare disorders of thyroid hormone resistance, TSH and, in mild cases, also thyroid hormone levels are within the normal range. Thyroid hormone resistance is caused by defects in hormone metabolism, transport, or receptor activation and can have the same serious consequences for child development as congenital hypothyroidism. A total of n = 23,522 data points from a large cohort of children and young adults were used to generate normal values and sex-specific percentiles for the ratio of free triiodothyronine (T3) to free thyroxine (T4), the fT3/fT4 ratio. The aim was to determine whether individuals with developmental delay and genetically confirmed thyroid hormone resistance, carrying defects in Monocarboxylate Transporter 8 (MCT8), Thyroid Hormone Receptor alpha (THRα), and Selenocysteine Insertion Sequence-Binding Protein 2 (SECISBP2), had abnormal fT3/fT4 ratios. Indeed, we were able to demonstrate a clear separation of patient values for the fT3/fT4 ratio from normal and pathological controls (e.g., children with severe cerebral palsy). We therefore recommend using the fT3/fT4 ratio as a readily available screening parameter in children with developmental delay for the identification of thyroid hormone resistance syndromes. The fT3/fT4 ratio can be easily plotted on centile charts using our free online tool, which accepts various SI and non-SI units for fT3, fT4, and TSH. [ABSTRACT FROM AUTHOR]

Published
2024
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12. Acute psychosocial stress alters thalamic network centrality

Author

Reinelt, Janis, Uhlig, Marie, Müller, Karsten, Lauckner, Mark E., Kumral, Deniz, Schaare, H. Lina, Baczkowski, Blazej M., Babayan, Anahit, Erbey, Miray, Roebbig, Josefin, Reiter, Andrea, Bae, Yoon-Ju, Kratzsch, Juergen, Thiery, Joachim, Hendler, Talma, Villringer, Arno, and Gaebler, Michael

Published
2019
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17. Efficacy of vildagliptin for prevention of postpartum diabetes in women with a recent history of insulin-requiring gestational diabetes: A phase II, randomized, double-blind, placebo-controlled study

Author

Walter, Markus, Börschmann, Heike, Ebe, Sophia, Giannopoulou, Eleni, Harsunen, Minna, Hofbauer, Veronika, Hofelich, Anna, Schuppenies, Andrea, Wallner, Maike, Wiesenäcker, David, Zillmer, Stephanie, Bunk, Melanie, Herbst, Melanie, Hivner, Susanne, Lachmann, Lorenz, Much, Daniela, Peplow, Claudia, Hasford, Joerg, Pfirrmann, Markus, Landgraf, Rüdiger, Maria Schneider, Karl-Theo, André, Elisabeth, Janke, Viktoria, Beyerlein, Andreas, Hummel, Sandra, Bonifacio, Ezio, Füchtenbusch, Martin, Hummel, Michael, Kohn, Denise, Hummel, Nadine, Kratzsch, Jürgen, and Ziegler, Anette-G.

Published
2018
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21. The LIFE Child study: a population-based perinatal and pediatric cohort in Germany

Author

the LIFE Child study team, Poulain, Tanja, Baber, Ronny, Vogel, Mandy, Pietzner, Diana, Kirsten, Toralf, Jurkutat, Anne, Hiemisch, Andreas, Hilbert, Anja, Kratzsch, Jürgen, Thiery, Joachim, Fuchs, Michael, Hirsch, Christian, Rauscher, Franziska G., Loeffler, Markus, Körner, Antje, Nüchter, Matthias, and Kiess, Wieland

Published
2017

26. Genetic dissection of serum vaspin highlights its causal role in lipid metabolism.

Author

Breitfeld, Jana, Horn, Katrin, Le Duc, Diana, Velluva, Akhil, Marzi, Carola, Grallert, Harald, Friedrich, Nele, Pietzner, Maik, Völker, Uwe, Völzke, Henry, Ahlqvist, Emma, Aly, Dina Mansour, Tuomi, Tiinamaija, Baber, Ronny, Kratzsch, Jürgen, Thiery, Joachim, Isermann, Berend, Loeffler, Markus, Klöting, Nora, and Blüher, Matthias

Subjects
LIPID metabolism, GENETIC variation, GENE expression, BLOOD lipids, GENOME-wide association studies
Abstract

Objective: Vaspin (visceral adipose tissue derived serine protease inhibitor, SERPINA12) is associated with obesity‐related metabolic traits, but its causative role is still elusive. The role of genetics in serum vaspin variability to establish its causal relationship with metabolically relevant traits was investigated. Methods: A meta‐analysis of genome‐wide association studies for serum vaspin from six independent cohorts (N = 7446) was conducted. Potential functional variants of vaspin were included in Mendelian randomization (MR) analyses to assess possible causal pathways between vaspin and homeostasis model assessment and lipid traits. To further validate the MR analyses, data from Genotype‐Tissue Expression (GTEx) were analyzed, db/db mice were treated with vaspin, and serum lipids were measured. Results: A total of 468 genetic variants represented by five independent variants (rs7141073, rs1956709, rs4905216, rs61978267, rs73338689) within the vaspin locus were associated with serum vaspin (all p < 5×10−8, explained variance 16.8%). MR analyses revealed causal relationships between serum vaspin and triglycerides, low‐density lipoprotein, and total cholesterol. Gene expression correlation analyses suggested that genes, highly correlated with vaspin expression in adipose tissue, are enriched in lipid metabolic processes. Finally, in vivo vaspin treatment reduced serum triglycerides in obese db/db mice. Conclusions: The data show that serum vaspin is strongly determined by genetic variants within vaspin, which further highlight vaspin's causal role in lipid metabolism. [ABSTRACT FROM AUTHOR]

Published
2023
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32. Leptin, but not ghrelin, is associated with food addiction scores in a population-based subject sample.

Author

Wittekind, Dirk Alexander, Kratzsch, Jürgen, Mergl, Roland, Baber, Ronny, Wirkner, Kerstin, Schroeter, Matthias L., Witte, A. Veronica, Villringer, Arno, and Kluge, Michael

Subjects
COMPULSIVE eating, GHRELIN, LEPTIN, PEPTIDE hormones, GENERALIZED anxiety disorder
Abstract

Background: Ghrelin and leptin are both peptide hormones and act as opposing players in the regulation of hunger, satiety and energy expenditure. Leptin reduces appetite and feelings of hunger and is secreted mainly by adipocytes, while ghrelin increases appetite and food intake and reduces metabolic rate. Both hormones have been implicated in addictive disorders. Ghrelin was shown to have proaddictive effects while leptin's role in addiction yields more conflicting results. Their involvement in the regulation of both food intake and addictive behaviors make them interesting candidates when investigating the regulation of food addiction. However, only few human studies have been performed and large-scale studies are lacking to date. We aimed to investigate the association between total ghrelin and leptin serum levels with scores in the Yale Food Addiction Scale (YFAS). Methods: Subjects were recruited in the LIFE Adult cohort. 909 subjects were included in the analysis and we performed univariate multiple linear regression models, adjusted for age, sex (in total group analyses only), alcohol consumption, smoking status, BMI scores, cortisol concentrations, Center for Epidemiological Studies Depression Scale (CES-D) and the 7-item Generalized Anxiety Disorder Scale (GAD-7) sum scores. The dependent variable was the YFAS score. Results: In men, leptin serum levels showed a significant positive association (standardized β = 0.146; p = 0.012) with the YFAS score. This finding was confirmed in an extreme-group comparison: men in the highest quartile of leptin levels had significantly higher YFAS sum scores than men in the lowest quartile (1.55 vs. 1.18; p = 0.00014). There was no association with YFAS sum score in the total group (standardized β = -0.002; p = 0.974) or in women (standardized β = -0.034; p = 0.674). Total serum ghrelin showed no association with YFAS sum score neither in the total group (standardized β = -0.043; p = 0.196) nor in men (n = 530; standardized β = -0.063; p = 0.135) or women (n = 379; standardized β = -0.035; p = 0.494). Conclusion: Our findings are in line with previous literature and suggest that total ghrelin serum levels are not associated with food addiction scores. Leptin had been previously shown to be associated with food addiction and we confirmed this finding for men in a large, population-based approach. [ABSTRACT FROM AUTHOR]

Published
2023
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44. FSTL3 is increased in renal dysfunction

Author

Kralisch, Susan, Hoffmann, Annett, Klöting, Nora, Bachmann, Anette, Kratzsch, Jürgen, Stolzenburg, Jens-Uwe, Dietel, Anja, Beige, Joachim, Anders, Matthias, Bast, Ingolf, Blüher, Matthias, Zhang, Ming-Zhi, Harris, Raymond C., Stumvoll, Michael, Fasshauer, Mathias, and Ebert, Thomas

Published
2017
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45. Free thyroxine measurement in clinical practice: how to optimize indications, analytical procedures, and interpretation criteria while waiting for global standardization.

Author

D'Aurizio, Federica, Kratzsch, Jürgen, Gruson, Damien, Petranović Ovčariček, Petra, and Giovanella, Luca

Subjects
*PROFESSIONAL practice, *THYROID diseases, *HYPOTHYROIDISM, *THYROXINE, *HYPERTHYROIDISM, *IMMUNOASSAY, *THYROID gland
Abstract

Thyroid dysfunctions are among the most common endocrine disorders and accurate biochemical testing is needed to confirm or rule out a diagnosis. Notably, true hyperthyroidism and hypothyroidism in the setting of a normal thyroid-stimulating hormone level are highly unlikely, making the assessment of free thyroxine (FT4) inappropriate in most new cases. However, FT4 measurement is integral in both the diagnosis and management of relevant central dysfunctions (central hypothyroidism and central hyperthyroidism) as well as for monitoring therapy in hyperthyroid patients treated with anti-thyroid drugs or radioiodine. In such settings, accurate FT4 quantification is required. Global standardization will improve the comparability of the results across laboratories and allow the development of common clinical decision limits in evidence-based guidelines. The International Federation of Clinical Chemistry and Laboratory Medicine Committee for Standardization of Thyroid Function Tests has undertaken FT4 immunoassay method comparison and recalibration studies and developed a reference measurement procedure that is currently being validated. However, technical and implementation challenges, including the establishment of different clinical decision limits for distinct patient groups, still remain. Accordingly, different assays and reference values cannot be interchanged. Two-way communication between the laboratory and clinical specialists is pivotal to properly select a reliable FT4 assay, establish reference intervals, investigate discordant results, and monitor the analytical and clinical performance of the method over time. [ABSTRACT FROM AUTHOR]

Published
2023
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