569 results on '"Krack P"'
Search Results
2. Prognosis of impulse control disorders in Parkinson’s disease: a prospective controlled study
- Author
-
Wirth, Thomas, Goetsch, Thibaut, Corvol, Jean-Christophe, Roze, Emmanuel, Mariani, Louise-Laure, Vidailhet, Marie, Grabli, David, Mallet, Luc, Pelissolo, Antoine, Rascol, Olivier, Brefel-Courbon, Christine, Ory-Magne, Fabienne, Arbus, Christophe, Bekadar, Samir, Krystkowiak, Pierre, Marques, Ana, Llorca, Michel, Krack, Paul, Castrioto, Anna, Fraix, Valérie, Maltete, David, Defebvre, Luc, Kreisler, Alexandre, Houeto, Jean-Luc, Tranchant, Christine, Meyer, Nicolas, and Anheim, Mathieu
- Published
- 2024
- Full Text
- View/download PDF
3. Unobtrusive measurement of gait parameters using seismographs: An observational study
- Author
-
Single, Michael, Bruhin, Lena C., Naef, Aileen C., Krack, Paul, Nef, Tobias, and Gerber, Stephan M.
- Published
- 2024
- Full Text
- View/download PDF
4. Role of sleep in neurodegeneration: the consensus report of the 5th Think Tank World Sleep Forum
- Author
-
Ferini-Strambi, Luigi, Liguori, Claudio, Lucey, Brendan P., Mander, Bryce A., Spira, Adam P., Videnovic, Aleksandar, Baumann, Christian, Franco, Oscar, Fernandes, Mariana, Gnarra, Oriella, Krack, Paul, Manconi, Mauro, Noain, Daniela, Saxena, Smita, Kallweit, Ulf, Randerath, Winfried, Trenkwalder, C., Rosenzweig, Ivana, Iranzo, Alex, Bradicich, Matteo, and Bassetti, Claudio
- Published
- 2024
- Full Text
- View/download PDF
5. How to verify the precision of density-functional-theory implementations via reproducible and universal workflows
- Author
-
Bosoni, Emanuele, Beal, Louis, Bercx, Marnik, Blaha, Peter, Blügel, Stefan, Bröder, Jens, Callsen, Martin, Cottenier, Stefaan, Degomme, Augustin, Dikan, Vladimir, Eimre, Kristjan, Flage-Larsen, Espen, Fornari, Marco, Garcia, Alberto, Genovese, Luigi, Giantomassi, Matteo, Huber, Sebastiaan P., Janssen, Henning, Kastlunger, Georg, Krack, Matthias, Kresse, Georg, Kühne, Thomas D., Lejaeghere, Kurt, Madsen, Georg K. H., Marsman, Martijn, Marzari, Nicola, Michalicek, Gregor, Mirhosseini, Hossein, Müller, Tiziano M. A., Petretto, Guido, Pickard, Chris J., Poncé, Samuel, Rignanese, Gian-Marco, Rubel, Oleg, Ruh, Thomas, Sluydts, Michael, Vanpoucke, Danny E. P., Vijay, Sudarshan, Wolloch, Michael, Wortmann, Daniel, Yakutovich, Aliaksandr V., Yu, Jusong, Zadoks, Austin, Zhu, Bonan, and Pizzi, Giovanni
- Published
- 2024
- Full Text
- View/download PDF
6. Unobtrusive measurement of gait parameters using seismographs: An observational study
- Author
-
Michael Single, Lena C. Bruhin, Aileen C. Naef, Paul Krack, Tobias Nef, and Stephan M. Gerber
- Subjects
Medicine ,Science - Abstract
Abstract Analyzing irregularities in walking patterns helps detect human locomotion abnormalities that can signal health changes. Traditional observation-based assessments have limitations due to subjective biases and capture only a single time point. Ambient and wearable sensor technologies allow continuous and objective locomotion monitoring but face challenges due to the need for specialized expertise and user compliance. This work proposes a seismograph-based algorithm for quantifying human gait, incorporating a step extraction algorithm derived from mathematical morphologies, with the goal of achieving the accuracy of clinical reference systems. To evaluate our method, we compared the gait parameters of 50 healthy participants, as recorded by seismographs, and those obtained from reference systems (a pressure-sensitive walkway and a camera system). Participants performed four walking tests, including traversing a walkway and completing the timed up-and-go (TUG) test. In our findings, we observed linear relationships with strong positive correlations (R 2 > 0.9) and tight 95% confidence intervals for all gait parameters (step time, cycle time, ambulation time, and cadence). We demonstrated that clinical gait parameters and TUG mobility test timings can be accurately derived from seismographic signals, with our method exhibiting no significant differences from established clinical reference systems.
- Published
- 2024
- Full Text
- View/download PDF
7. The LHC as a Neutrino-Ion Collider
- Author
-
Juan M. Cruz-Martinez, Max Fieg, Tommaso Giani, Peter Krack, Toni Mäkelä, Tanjona R. Rabemananjara, and Juan Rojo
- Subjects
Astrophysics ,QB460-466 ,Nuclear and particle physics. Atomic energy. Radioactivity ,QC770-798 - Abstract
Abstract Proton-proton collisions at the LHC generate a high-intensity collimated beam of neutrinos in the forward (beam) direction, characterised by energies of up to several TeV. The recent observation of LHC neutrinos by FASER $$\nu $$ ν and SND@LHC signifies that this previously overlooked particle beam is now available for scientific investigation. Here we quantify the impact that neutrino deep-inelastic scattering (DIS) measurements at the LHC would have on the parton distributions (PDFs) of protons and heavy nuclei. We generate projections for DIS structure functions for FASER $$\nu $$ ν and SND@LHC at Run III, as well as for the FASER $$\nu $$ ν 2, AdvSND, and FLArE experiments to be hosted at the proposed Forward Physics Facility (FPF) operating concurrently with the High-Luminosity LHC (HL-LHC). We determine that up to one million electron-neutrino and muon-neutrino DIS interactions within detector acceptance can be expected by the end of the HL-LHC, covering a kinematic region in x and $$Q^2$$ Q 2 overlapping with that of the Electron-Ion Collider. Including these DIS projections in global (n)PDF analyses, specifically PDF4LHC21, NNPDF4.0, and EPPS21, reveals a significant reduction in PDF uncertainties, in particular for strangeness and the up and down valence PDFs. We show that LHC neutrino data enable improved theoretical predictions for core processes at the HL-LHC, such as Higgs and weak gauge boson production. Our analysis demonstrates that exploiting the LHC neutrino beam effectively provides CERN with a “Neutrino-Ion Collider” without requiring modifications in its accelerator infrastructure.
- Published
- 2024
- Full Text
- View/download PDF
8. The LHC as a Neutrino-Ion Collider
- Author
-
Cruz-Martinez, Juan M., Fieg, Max, Giani, Tommaso, Krack, Peter, Mäkelä, Toni, Rabemananjara, Tanjona R., and Rojo, Juan
- Published
- 2024
- Full Text
- View/download PDF
9. Alterations in the plasma proteome persist ten months after recovery from mild to moderate SARS-CoV-2 infection
- Author
-
Julio A. Huapaya, Salina Gairhe, Shreya Kanth, Xin Tian, Cumhur Y. Demirkale, David Regenold, Jian Sun, Nicolas F. Lynch, Renjie Luo, Alisa Forsberg, Robin Dewar, Tauseef Rehman, Willy Li, Janell Krack, Janaki Kuruppu, Etsubdink A. Aboye, Christopher Barnett, Jeffrey R. Strich, Richard Davey, Richard Childs, Daniel Chertow, Joseph A. Kovacs, Parizad Torabi-Parizi, and Anthony F. Suffredini
- Subjects
SARS-CoV-2 ,proteomics ,vaccination ,breakthrough infections ,post-acute sequelae ,inflammation ,Immunologic diseases. Allergy ,RC581-607 - Abstract
BackgroundLimited data are available describing the effects of SARS-CoV-2 breakthrough infections on the plasma proteome.MethodsPCR-positive SARS-CoV-2 patients, enrolled in a natural history study, underwent analysis of the plasma proteome. A prospective cohort of 66 unvaccinated and 24 vaccinated persons with different degrees of infection severity were evaluated acutely (within 40 days of symptom onset), and at three and ten months. Comparisons based on vaccination status alone and unsupervised hierarchical clustering were performed. A second cohort of vaccinated Omicron patients were evaluated acutely and at ten months.ResultsAcutely, unvaccinated patients manifested overexpression of proteins involved in immune and inflammatory responses, while vaccinated patients exhibited adaptive immune responses without significant inflammation. At three and ten months, only unvaccinated patients had diminished but sustained inflammatory (C3b, CCL15, IL17RE) and immune responses (DEFA5,TREM1). Both groups had underexpression of pathways essential for cellular function, signaling, and angiogenesis (AKT1, MAPK14, HSPB1) across phases. Unsupervised clustering, based on protein expression, identified four groups of patients with variable vaccination rates demonstrating that additional clinical factors influence the plasma proteome. The proteome of vaccinated Omicron patients did not differ from vaccinated pre-Omicron patients.ConclusionsVaccination attenuates the inflammatory response to SARS-CoV-2 infection across phases. However, at ten months after symptom onset, changes in the plasma proteome persist in both vaccinated and unvaccinated individuals, which may be relevant to post-acute sequelae of SARS-CoV-2 and other viral infections associated with post-acute infection syndromes.
- Published
- 2024
- Full Text
- View/download PDF
10. Should asleep deep brain stimulation in Parkinson’s disease be preferred over the awake approach? – Pros
- Author
-
Gerd Tinkhauser, Claudio Pollo, Ines Debove, Andreas Nowacki, and Paul Krack
- Subjects
Medicine - Abstract
No abstract available.
- Published
- 2024
- Full Text
- View/download PDF
11. Interventions to improve system-level coproduction in the Cystic Fibrosis Learning Network
- Author
-
Rachel Gordon, Lillian O’Leary, Gregory Sawicki, Don B Sanders, David Miller, Peter J Murphy, Michael Seid, John Dickinson, Mary Lester, Catherine Hopkins, Adrienne Savant, Rebekah Brown, Preeti Sharma, Christian Merlo, Michelle Roberts, Kathryn A Sabadosa, David Hansen, Peter Michelson, Amy Filbrun, Jordan Dunitz, Christopher M Siracusa, Thida Ong, Stacy Bichl, Ahmet Uluer, Joanne Cullina, Michael Powers, Rhonda List, Lindsay Somerville, Lauren Williamson, Dana Albon, Hossein Sadeghi, Clement Ren, Thomas Keens, Nicholas Antos, Fadi Asfour, Mike Price, Kristen Nowak, Robert Balk, Erin Moore, Prigi Varghese, Cori Daines, Glenda Drake, Amy Lucero, Amanda Sharpe, Lindsey McMahon, Meghan Murray, Meghana Sathe, Traci Liberto, Rachel Linnemann, Pornchai Tirakitsoontorn, Maivy Sou, Michael Schechter, Andrea Molzhon, Karen Wunschel, Lisa A Mullen, Kyle Traver, Travis Burgett, Alex Gifford, Nicola Felicetti, Heidi Dolan, Tracey Gendreau, Danielle Beachler, Shine-Ann Pai, Stephanie Robbins, Ben McCullar, Lauren Mitchell, Andrew Scaljon, Stefanie Rushing, Golnar Raissi, Bean Corcoran, Michelle Prickett, Rachel Nelson, Stacy Allen, Lisa Greene, Sara Renschen, Betsy Price, Catherine Kier, Teresa Carney, Sandy Corr, Barbara Leyva, Jillian Salvatore, George M Solomon, Julianna Bailey, James Lawlor, Samya Z Nasr, Rebekah Raines, Catherine Enochs, Kristen Jesse, Jonathan Flath, Mackenzie Wharram, James Tolle, Susan Eastman, Nauman Chaudary, Mahsa Farsad, Kimberly Wingo, Kathryn Moffett, Erin Brozik, Paige Krack, Kevin Martin, Laura Roth, Joshua Wang, Sarah Dykes, Erin Newbill, Misty Thompson, Danielle Poulin, Breck Gamel, Srujana Bandla, David W Davison, Lindsay Silva, Raouf Amin, Maria Britto, Anna Saulitis, Kate Barnico, Cindy Murphy, Amanda Lemieux, Georgia Dangel, Melanie Lawrence, Danielle Goetz, Danielle Woerner, Megan Whelan, Katelyn Violanti, Susan Attel, Alexia Hernández Cargal, Kelly Clute, Olivia Ries, Susan Gage, Bridget Kominek, Kristin Lawrence, Megan Martin, Jessica Roach, Errin Newman, Phillip Vaden, Esther Giezendanner, Marsha Triana, Sujal Rangwalla, Meghann Weil, Randy Hunt, Emily Walker, Caroline Starnes, Kendra Adderhold, Megan Barker, Johanna Zea-Hernandez, Beth Debri, Ann Kaiser, Cindy Brown, Pi Chun Cheng, Jana Yeley, Laura Jay-Ballinger, Julian McConnie, Meghana Malapaka, Perry Aulie, Ginger Birnbaum, Cynthia Driskill, Janerisa Encarnacion, Amanda Oswald, Stephanie Fullmer, Anthony Fashoda, Laura Steinhaus, Maureen Tinley, Jame’ Vajda, Janine Cassidy, Mey Lee, Megan Akers, Susan Whitmore, Christian Santaniello, Robert Abdullah, Bryan Garcia, Cameron Crenshaw, Kandice Amos, Veronica Indihar, Lisa Shively, Anissa Hostetter, Angela Oder, Brandi Morgan, Kayla Hubley, Deborah K Froh, Holly Carroll-Owen, Lauren Miller Ahrens, Brielle Evangelista, Lucy Gettle, Tracie O'Sullivan, Autumn Bonstein, Stacey Miller, Angela Bender, Billie Jo Bennett, John Palla, Cathy O'Malley, Maria Dowell, Allison Fitch-Markham, Chladd Ford, Carolyn Heyman, Terri Laguna, Debbie Benitez, Lynn Fukushima, Martha Markovitz, Adupa Rao, Gregory Storm, Vai Jun Lam, John Mercer, Cori Muirhead, Jeff Gold, Aaron Trimble, Gopal Allada, Wendy Palmrose, Sue Sullivan, Kim Keeling, Rob Shradar, Jill Fliege, Heidi Klasna, Janelle Sorensen, Stacy Millikan, Joe Poler, Jill Rollins, Sandy Wahl, Cristy Batten, Laura Romero, Whitney Gore, Kimberly Morse, Rocio Munter, Danieli Salinas, Sylvia Sanchez, Virginia Anderson, Jami Dunn, Stephanie Gamble, Hector Gutierrez, Kelli Lachowicz, Isabel Lowell, Cathy Mims, LaShonna Stodghill, Gabriela Oates, Amanda Phillips, Linda Russo, Staci Self, Julie Desch, Ilene Hollin, Emily Kramer-Golinkoff, Pamela Mertz, Sarah Gomez, Nancy Griffin, and Drew Warmin
- Subjects
Medicine (General) ,R5-920 - Abstract
Background Coproduction is defined as patients and clinicians collaborating equally and reciprocally in healthcare and is a crucial concept for quality improvement (QI) of health services. Learning Health Networks (LHNs) provide insights to integrate coproduction with QI efforts from programmes from various health systems.Objective We describe interventions to develop and maintain patient and family partner (PFP) coproduction, measured by PFP-reported and programme-reported scales. We aim to increase percentage of programmes with PFPs reporting active QI work within their programme, while maintaining satisfaction in PFP-clinician relationships.Methods Conducted in the Cystic Fibrosis Learning Network (CFLN), an LHN comprising over 30 cystic fibrosis (CF) programmes, people with CF, caregivers and clinicians cocreated interventions in readiness awareness, inclusive PFP recruitment, onboarding process, partnership development and leadership opportunities. Interventions were adapted by CFLN programmes and summarised in a change package for existing programmes and the orientation of new ones. We collected monthly assessments for PFP and programme perceptions of coproduction and PFP self-rated competency of QI skills and satisfaction with programme QI efforts. We used control charts to analyse coproduction scales and run charts for PFP self-ratings.Results Between 2018 and 2022, the CFLN expanded to 34 programmes with 52% having ≥1 PFP reporting active QI participation. Clinicians from 76% of programmes reported PFPs were actively participating or leading QI efforts. PFPs reported increased QI skills competency (17%–32%) and consistently high satisfaction and feeling valued in their work.Conclusions Implementing system-level programmatic strategies to engage and sustain partnerships between clinicians and patients and families with CF improved perceptions of coproduction to conduct QI work. Key adaptable strategies for programmes included onboarding and QI training, supporting multiple PFPs simultaneously and developing financial recognition processes. Interventions may be applicable in other health conditions beyond CF seeking to foster the practice of coproduction.
- Published
- 2024
- Full Text
- View/download PDF
12. Third-family lepton-quark fusion
- Author
-
Arman Korajac, Peter Krack, and Nudžeim Selimović
- Subjects
Astrophysics ,QB460-466 ,Nuclear and particle physics. Atomic energy. Radioactivity ,QC770-798 - Abstract
Abstract We analyze the signatures of new physics scenarios featuring third-family quark-lepton unification at the TeV scale in lepton-quark fusion at hadron colliders. Working with complete UV dynamics based on the SU(4) gauge symmetry in the third-family fermions, we simulate the resonant production of a vector leptoquark at the next-to-leading order, including its decay and matching to the parton showers. The precise theoretical control over this production channel allows us to set robust bounds on the vector leptoquark parameter space which are complementary to the other production channels at colliders. We emphasize the importance of the resonant channel in future searches and discuss the impact of variations in the model space depending on the flavor structure of the vector leptoquark couplings.
- Published
- 2024
- Full Text
- View/download PDF
13. Third-family lepton-quark fusion
- Author
-
Korajac, Arman, Krack, Peter, and Selimović, Nudžeim
- Published
- 2024
- Full Text
- View/download PDF
14. Subthalamic stimulation has acute psychotropic effects and improves neuropsychiatric fluctuations in Parkinson’s disease
- Author
-
Mário Sousa, Paul Krack, Ines Debove, Martin Lenard Lachenmayer, Pablo Martinez-Martin, Carmen Rodriguez-Blazquez, Andreia D Magalhães, Deborah Amstutz, Katrin Petermann, Marie E Maradan-Gachet, Julia Waskönig, Sandra Murcia-Carretero, Andreas Antonios Diamantaras, Gerd Tinkhauser, Andreas Nowacki, and Claudio Pollo
- Subjects
Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
Background Subthalamic nucleus deep brain stimulation (STN-DBS) is a well-established treatment for motor complications in Parkinson’s disease (PD). However, its effects on neuropsychiatric symptoms remain disputed. The aim of this study was to evaluate the effects of STN-DBS on neuropsychiatric symptoms in PD.Methods We retrospectively assessed 26 patients with PD who underwent a preoperative levodopa challenge and postoperative levodopa and stimulation challenges 1 year after STN-DBS. Based on the Neuropsychiatric Fluctuations Scale, Neuropsychiatric State Scores and Neuropsychiatric Fluctuation Indices (NFIs) were calculated. Mixed-effects models with random effects for intercept were used to examine the association of Neuropsychiatric State Score and NFI with the different assessment conditions.Results In acute challenge conditions, there was an estimated increase of 15.9 points in the Neuropsychiatric State Score in stimulation ON conditions (95% CI 11.4 to 20.6, p
- Published
- 2024
- Full Text
- View/download PDF
15. Correction to: Role of sleep in neurodegeneration: the consensus report of the 5th Think Tank World Sleep Forum
- Author
-
Ferini‑Strambi, Luigi, Liguori, Claudio, Lucey, Brendan P., Mander, Bryce A., Spira, Adam P., Videnovic, Aleksandar, Baumann, Christian, Franco, Oscar, Fernandes, Mariana, Gnarra, Oriella, Krack, Paul, Manconi, Mauro, Noain, Daniela, Saxena, Smita, Kallweit, Ulf, Randerath, Winfried, Trenkwalder, C., Rosenzweig, Ivana, Iranzo, Alex, Bradicich, Matteo, and Bassetti, Claudio
- Published
- 2024
- Full Text
- View/download PDF
16. Imbalanced motivated behaviors according to motor sign asymmetry in drug-naïve Parkinson’s disease
- Author
-
Matthieu Béreau, Anna Castrioto, Mathieu Servant, Eugénie Lhommée, Maxime Desmarets, Amélie Bichon, Pierre Pélissier, Emmanuelle Schmitt, Hélène Klinger, Nadine Longato, Clélie Phillipps, Thomas Wirth, Valérie Fraix, Isabelle Benatru, Franck Durif, Jean-Philippe Azulay, Elena Moro, Emmanuel Broussolle, Stéphane Thobois, Christine Tranchant, Paul Krack, and Mathieu Anheim
- Subjects
Medicine ,Science - Abstract
Abstract Few studies have considered the influence of motor sign asymmetry on motivated behaviors in de novo drug-naïve Parkinson’s disease (PD). We tested whether motor sign asymmetry could be associated with different motivated behavior patterns in de novo drug-naïve PD. We performed a cross-sectional study in 128 de novo drug-naïve PD patients and used the Ardouin Scale of Behavior in Parkinson’s disease (ASBPD) to assess a set of motivated behaviors. We assessed motor asymmetry based on (i) side of motor onset and (ii) MDS-UPDRS motor score, then we compared right hemibody Parkinson’s disease to left hemibody Parkinson’s disease. According to the MDS-UPDRS motor score, patients with de novo right hemibody PD had significantly lower frequency of approach behaviors (p = 0.031), including nocturnal hyperactivity (p = 0.040), eating behavior (p = 0.040), creativity (p = 0.040), and excess of motivation (p = 0.017) than patients with de novo left hemibody PD. Patients with de novo left hemibody PD did not significantly differ from those with de novo right hemibody PD regarding avoidance behaviors including apathy, anxiety and depression. Our findings suggest that motor sign asymmetry may be associated with an imbalance between motivated behaviors in de novo drug-naïve Parkinson’s disease.
- Published
- 2023
- Full Text
- View/download PDF
17. Electroencephalographic Abnormalities in a Patient Suffering from Long-Term Neuropsychological Complications following SARS-CoV-2 Infection
- Author
-
Damien Benis, Philippe Voruz, Sabina Catalano Chiuve, Valentina Garibotto, Frédéric Assal, Paul Krack, Julie Péron, and Vanessa Fleury
- Subjects
long covid ,neuropsychological disturbances ,apathy ,eeg ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Introduction: Emotional apathy has recently been identified as a common symptom of long COVID. While recent meta-analyses have demonstrated generalized EEG slowing with the emergence of delta rhythms in patients hospitalized for severe SARS-CoV-2 infection, no EEG study or dopamine transporter scintigraphy (DaTSCAN) has been performed in patients with long COVID presenting with apathy. The objective of this case report was to explore the pathophysiology of neuropsychological symptoms in long COVID. Case Presentation: A 47-year-old patient who developed a long COVID with prominent apathy following an initially clinically mild SARS-CoV-2 infection underwent neuropsychological assessment, cerebral MRI, DaTSCAN, and resting-state high-density EEG 7 months after SARS-CoV-2 infection. The EEG data were compared to those of 21 healthy participants. The patient presented with apathy, cognitive difficulties with dysexecutive syndrome, moderate attentional and verbal episodic memory disturbances, and resolution of premorbid mild gaming disorder, mild mood disturbances, and sleep disturbances. His MRI and DaTSCAN were unremarkable. EEG revealed a complex pattern of oscillatory abnormalities compared to the control group, with a strong increase in whole-scalp delta and beta band activity, as well as a decrease in alpha band activity. Overall, these effects were more prominent in the frontal-central-temporal region. Conclusion: These results suggest widespread changes in EEG oscillatory patterns in a patient with long COVID characterized by neuropsychological complications with prominent apathy. Despite the inherent limitations of a case report, these results suggest dysfunction in the cortical networks involved in motivation and emotion.
- Published
- 2023
- Full Text
- View/download PDF
18. Distinct and targetable role of calcium-sensing receptor in leukaemia
- Author
-
Raquel S. Pereira, Rahul Kumar, Alessia Cais, Lara Paulini, Alisa Kahler, Jimena Bravo, Valentina R. Minciacchi, Theresa Krack, Eric Kowarz, Costanza Zanetti, Parimala Sonika Godavarthy, Fabian Hoeller, Pablo Llavona, Tabea Stark, Georg Tascher, Daniel Nowak, Eshwar Meduri, Brian J. P. Huntly, Christian Münch, Francesco Pampaloni, Rolf Marschalek, and Daniela S. Krause
- Subjects
Science - Abstract
Abstract Haematopoietic stem cells (HSC) reside in the bone marrow microenvironment (BMM), where they respond to extracellular calcium [eCa2+] via the G-protein coupled calcium-sensing receptor (CaSR). Here we show that a calcium gradient exists in this BMM, and that [eCa2+] and response to [eCa2+] differ between leukaemias. CaSR influences the location of MLL-AF9+ acute myeloid leukaemia (AML) cells within this niche and differentially impacts MLL-AF9+ AML versus BCR-ABL1+ leukaemias. Deficiency of CaSR reduces AML leukaemic stem cells (LSC) 6.5-fold. CaSR interacts with filamin A, a crosslinker of actin filaments, affects stemness-associated factors and modulates pERK, β-catenin and c-MYC signaling and intracellular levels of [Ca2+] in MLL-AF9+ AML cells. Combination treatment of cytarabine plus CaSR-inhibition in various models may be superior to cytarabine alone. Our studies suggest CaSR to be a differential and targetable factor in leukaemia progression influencing self-renewal of AML LSC via [eCa2+] cues from the BMM.
- Published
- 2023
- Full Text
- View/download PDF
19. Long-Term Averaged Spectrum Descriptors of Dysarthria in Patients with Parkinson's Disease Treated with Subthalamic Nucleus Deep Brain Stimulation
- Author
-
Svihlik, Jan, Novotny, Michal, Tykalova, Tereza, Polakova, Kamila, Brozova, Hana, Kryze, Petr, Sousa, Mario, Krack, Paul, Tripoliti, Elina, Ruzicka, Evzen, Jech, Robert, and Rusz, Jan
- Abstract
Purpose: This study aimed to evaluate whether long-term averaged spectrum (LTAS) descriptors for reading and monologue are suitable to detect worsening of dysarthria in patients with Parkinson's disease (PD) treated with subthalamic nucleus deep brain stimulation (STN-DBS) with potential effect of ON and OFF stimulation conditions and types of connected speech. Method: Four spectral moments based on LTAS were computed for monologue and reading passage collected from 23 individuals with PD treated with bilateral STN-DBS and 23 age- and gender-matched healthy controls. Speech performance of patients with PD was compared in ON and OFF STN-DBS conditions. Results: All LTAS spectral moments including mean, standard deviation, skewness, and kurtosis across both monologue and reading passage were able to significantly distinguish between patients with PD in both stimulation conditions and control speakers. The spectral mean was the only LTAS measure sensitive to capture better speech performance in STN-DBS ON, as compared to the STN-DBS OFF stimulation condition (p < 0.05). Standardized reading passage was more sensitive compared to monologue in detecting dysarthria severity via LTAS descriptors with an area under the curve of up to 0.92 obtained between PD and control groups. Conclusions: Our findings confirmed that LTAS is a suitable approach to objectively describe changes in speech impairment severity due to STN-DBS therapy in patients with PD. We envisage these results as an important step toward a continuum development of technological solutions for the automated assessment of stimulation-induced dysarthria.
- Published
- 2022
- Full Text
- View/download PDF
20. Imbalanced motivated behaviors according to motor sign asymmetry in drug-naïve Parkinson’s disease
- Author
-
Béreau, Matthieu, Castrioto, Anna, Servant, Mathieu, Lhommée, Eugénie, Desmarets, Maxime, Bichon, Amélie, Pélissier, Pierre, Schmitt, Emmanuelle, Klinger, Hélène, Longato, Nadine, Phillipps, Clélie, Wirth, Thomas, Fraix, Valérie, Benatru, Isabelle, Durif, Franck, Azulay, Jean-Philippe, Moro, Elena, Broussolle, Emmanuel, Thobois, Stéphane, Tranchant, Christine, Krack, Paul, and Anheim, Mathieu
- Published
- 2023
- Full Text
- View/download PDF
21. Distinct and targetable role of calcium-sensing receptor in leukaemia
- Author
-
Pereira, Raquel S., Kumar, Rahul, Cais, Alessia, Paulini, Lara, Kahler, Alisa, Bravo, Jimena, Minciacchi, Valentina R., Krack, Theresa, Kowarz, Eric, Zanetti, Costanza, Godavarthy, Parimala Sonika, Hoeller, Fabian, Llavona, Pablo, Stark, Tabea, Tascher, Georg, Nowak, Daniel, Meduri, Eshwar, Huntly, Brian J. P., Münch, Christian, Pampaloni, Francesco, Marschalek, Rolf, and Krause, Daniela S.
- Published
- 2023
- Full Text
- View/download PDF
22. Late adult-onset Niemann Pick type C (NPC): An “atypical” typical presentation at the age of 62
- Author
-
Sousa, M., Maamari, B., Bremova, T., Nuoffer, J.M., Wiest, R., Amstutz, D., Krack, P., Bartholdi, D., and Tinkhauser, G.
- Published
- 2024
- Full Text
- View/download PDF
23. A Transferable Lidar-Based Method to Conduct Contactless Assessments of Gait Parameters in Diverse Home-like Environments
- Author
-
Michael Single, Lena C. Bruhin, Aaron Colombo, Kevin Möri, Stephan M. Gerber, Jacob Lahr, Paul Krack, Stefan Klöppel, René M. Müri, Urs P. Mosimann, and Tobias Nef
- Subjects
gait analysis ,Lidar ,ambient sensors ,person tracking ,health monitoring ,Chemical technology ,TP1-1185 - Abstract
Gait abnormalities in older adults are linked to increased risks of falls, institutionalization, and mortality, necessitating accurate and frequent gait assessments beyond traditional clinical settings. Current methods, such as pressure-sensitive walkways, often lack the continuous natural environment monitoring needed to understand an individual’s gait fully during their daily activities. To address this gap, we present a Lidar-based method capable of unobtrusively and continuously tracking human leg movements in diverse home-like environments, aiming to match the accuracy of a clinical reference measurement system. We developed a calibration-free step extraction algorithm based on mathematical morphology to realize Lidar-based gait analysis. Clinical gait parameters of 45 healthy individuals were measured using Lidar and reference systems (a pressure-sensitive walkway and a video recording system). Each participant participated in three predefined ambulation experiments by walking over the walkway. We observed linear relationships with strong positive correlations (R2>0.9) between the values of the gait parameters (step and stride length, step and stride time, cadence, and velocity) measured with the Lidar sensors and the pressure-sensitive walkway reference system. Moreover, the lower and upper 95% confidence intervals of all gait parameters were tight. The proposed algorithm can accurately derive gait parameters from Lidar data captured in home-like environments, with a performance not significantly less accurate than clinical reference systems.
- Published
- 2024
- Full Text
- View/download PDF
24. Resonant leptoquark at NLO with POWHEG
- Author
-
Luca Buonocore, Admir Greljo, Peter Krack, Paolo Nason, Nudžeim Selimović, Francesco Tramontano, and Giulia Zanderighi
- Subjects
Higher-Order Perturbative Calculations ,Specific BSM Phenomenology ,Parton Shower ,Nuclear and particle physics. Atomic energy. Radioactivity ,QC770-798 - Abstract
Abstract Recent progress in calculating lepton density functions inside the proton and simulating lepton showers laid the foundations for precision studies of resonant leptoquark production at hadron colliders. Direct quark-lepton fusion into a leptoquark is a novel production channel at the LHC that has the potential to probe a unique parameter space for large masses and couplings. In this work, we build the first Monte Carlo event generator for a full-fledged simulation of this process at NLO for production, followed by a subsequent decay using the POWHEG method and matching to the parton showers utilizing HERWIG. The code can handle all scalar leptoquark models with renormalisable quark-lepton interactions. We then comprehensively study the differential distributions, including higher-order effects, and assess the corresponding theoretical uncertainties. We also quantify the impact of the improved predictions on the projected (HL-)LHC sensitivities and initiate the first exploration of the potential at the FCC-hh. Our work paves the way toward performing LHC searches using this channel.
- Published
- 2022
- Full Text
- View/download PDF
25. Hemodynamic Effects of Sacubitril/Valsartan in Patients with Reduced Left Ventricular Ejection Fraction Over 24 Months: A Retrospective Study
- Author
-
Abumayyaleh, Mohammad, Demmer, Jonathan, Krack, Carina, Pilsinger, Christina, El-Battrawy, Ibrahim, Behnes, Michael, Aweimer, Assem, Mügge, Andreas, Lang, Siegfried, and Akin, Ibrahim
- Published
- 2022
- Full Text
- View/download PDF
26. Deep brain stimulation for obsessive–compulsive disorder: a crisis of access
- Author
-
Visser-Vandewalle, Veerle, Andrade, Pablo, Mosley, Philip E., Greenberg, Benjamin D., Schuurman, Rick, McLaughlin, Nicole C., Voon, Valerie, Krack, Paul, Foote, Kelly D., Mayberg, Helen S., Figee, Martijn, Kopell, Brian H., Polosan, Mircea, Joyce, Eileen M., Chabardes, Stephan, Matthews, Keith, Baldermann, Juan C., Tyagi, Himanshu, Holtzheimer, Paul E., Bervoets, Chris, Hamani, Clement, Karachi, Carine, Denys, Damiaan, Zrinzo, Ludvic, Blomstedt, Patric, Naesström, Matilda, Abosch, Aviva, Rasmussen, Steven, Coenen, Volker A., Schlaepfer, Thomas E., Dougherty, Darin D., Domenech, Philippe, Silburn, Peter, Giordano, James, Lozano, Andres M., Sheth, Sameer A., Coyne, Terry, Kuhn, Jens, Mallet, Luc, Nuttin, Bart, Hariz, Marwan, and Okun, Michael S.
- Published
- 2022
- Full Text
- View/download PDF
27. Intense cross-scale energy cascades resembling “mechanical turbulence” in harmonically driven strongly nonlinear hierarchical chains of oscillators
- Author
-
Chen, Jian En, Theurich, Timo, Krack, Malte, Sapsis, Themistoklis, Bergman, Lawrence A., and Vakakis, Alexander F.
- Published
- 2022
- Full Text
- View/download PDF
28. Identification with similar others sharing their experience of coping with depression and its effects on stigmatization and prosocial intentions
- Author
-
Freya Sukalla, Ina Krack, Daniel Seibert, Ludwig Paeth, Olga Frank, Ronja Preißler, and Philip Matias Block
- Subjects
Communication. Mass media ,P87-96 - Abstract
Addressing the high prevalence of depression among university students and the need to motivate professional help seeking, we examine whether recovery stories featuring a similar - compared to a dissimilar - person sharing their personal experience of coping with depression will reduce stigmatization (attitudes, social distance, prosocial intentions) and the self-stigma of help seeking as mediated by perceived similarity and identification. We conducted a one-factorial between-subject experiment to test the effects of lifestyle similarity on stigmatization and self-stigma of help seeking. 169 students (74.6% female; Mage = 23.5, SD = 3.5) were randomly assigned to read either a recovery story about a similar or dissimilar author’s reflections on their experience of coping with depression or a control story. Contrary to expectations, recovery stories did not reduce stigmatization nor the self-stigma of help seeking, irrespective of whether they were told by a similar or dissimilar person. However, a significant indirect effect on prosocial intentions through perceived similarity and identification as well as several interesting exploratory results point to potential beneficial and detrimental effects of recovery stories and similarity that should be explored in future research.
- Published
- 2022
- Full Text
- View/download PDF
29. Development of an Open-source and Lightweight Sensor Recording Software System for Conducting Biomedical Research: Technical Report
- Author
-
Michael Single, Lena C Bruhin, Narayan Schütz, Aileen C Naef, Heinz Hegi, Pascal Reuse, Kaspar A Schindler, Paul Krack, Roland Wiest, Andrew Chan, Tobias Nef, and Stephan M Gerber
- Subjects
Medicine - Abstract
BackgroundDigital sensing devices have become an increasingly important component of modern biomedical research, as they help provide objective insights into individuals’ everyday behavior in terms of changes in motor and nonmotor symptoms. However, there are significant barriers to the adoption of sensor-enhanced biomedical solutions in terms of both technical expertise and associated costs. The currently available solutions neither allow easy integration of custom sensing devices nor offer a practicable methodology in cases of limited resources. This has become particularly relevant, given the need for real-time sensor data that could help lower health care costs by reducing the frequency of clinical assessments performed by specialists and improve access to health assessments (eg, for people living in remote areas or older adults living at home). ObjectiveThe objective of this paper is to detail the end-to-end development of a novel sensor recording software system that supports the integration of heterogeneous sensor technologies, runs as an on-demand service on consumer-grade hardware to build sensor systems, and can be easily used to reliably record longitudinal sensor measurements in research settings. MethodsThe proposed software system is based on a server-client architecture, consisting of multiple self-contained microservices that communicated with each other (eg, the web server transfers data to a database instance) and were implemented as Docker containers. The design of the software is based on state-of-the-art open-source technologies (eg, Node.js or MongoDB), which fulfill nonfunctional requirements and reduce associated costs. A series of programs to facilitate the use of the software were documented. To demonstrate performance, the software was tested in 3 studies (2 gait studies and 1 behavioral study assessing activities of daily living) that ran between 2 and 225 days, with a total of 114 participants. We used descriptive statistics to evaluate longitudinal measurements for reliability, error rates, throughput rates, latency, and usability (with the System Usability Scale [SUS] and the Post-Study System Usability Questionnaire [PSSUQ]). ResultsThree qualitative features (event annotation program, sample delay analysis program, and monitoring dashboard) were elaborated and realized as integrated programs. Our quantitative findings demonstrate that the system operates reliably on consumer-grade hardware, even across multiple months (>420 days), providing high throughput (2000 requests per second) with a low latency and error rate (
- Published
- 2023
- Full Text
- View/download PDF
30. Spectral topography of the human subthalamic nucleus in Parkinson’s disease
- Author
-
Alberto Averna, Ines Debove, Andreas Nowacki, Katrin Peterman, Benoit Duchet, Mario Sousa, Elena Bernasconi, Laura Alva, Lenard Lachenmayer, Michael Schuepbach, Claudio Pollo, Paul Krack, Khoa Nguyen, and Gerd Tinkhauser
- Subjects
Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Published
- 2023
- Full Text
- View/download PDF
31. Resonant leptoquark at NLO with POWHEG
- Author
-
Buonocore, Luca, Greljo, Admir, Krack, Peter, Nason, Paolo, Selimović, Nudžeim, Tramontano, Francesco, and Zanderighi, Giulia
- Published
- 2022
- Full Text
- View/download PDF
32. Can Adherence to and Persistence with Inhaled Long-acting Bronchodilators Improve the Quality of Life in Patients with Chronic Obstructive Pulmonary Disease? Results from a German Disease Management Program
- Author
-
Krack, Gundula, Kirsch, Florian, Schwarzkopf, Larissa, Schramm, Anja, and Leidl, Reiner
- Published
- 2021
- Full Text
- View/download PDF
33. Analysis of the non-periodic oscillations of a self-excited friction-damped system with closely spaced modes
- Author
-
Woiwode, Lukas, Vakakis, Alexander F., and Krack, Malte
- Published
- 2021
- Full Text
- View/download PDF
34. Programming of subthalamic nucleus deep brain stimulation for Parkinson’s disease with sweet spot-guided parameter suggestions
- Author
-
Simon Nordenström, Katrin Petermann, Ines Debove, Andreas Nowacki, Paul Krack, Claudio Pollo, and T. A. Khoa Nguyen
- Subjects
deep brain stimulation ,Parkinson’s disease ,programming ,sweet spot ,subthalamic nucleus ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
Deep Brain Stimulation (DBS) is an effective treatment for advanced Parkinson’s disease. However, identifying stimulation parameters, such as contact and current amplitudes, is time-consuming based on trial and error. Directional leads add more stimulation options and render this process more challenging with a higher workload for neurologists and more discomfort for patients. In this study, a sweet spot-guided algorithm was developed that automatically suggested stimulation parameters. These suggestions were retrospectively compared to clinical monopolar reviews. A cohort of 24 Parkinson’s disease patients underwent bilateral DBS implantation in the subthalamic nucleus at our center. First, the DBS’ leads were reconstructed with the open-source toolbox Lead-DBS. Second, a sweet spot for rigidity reduction was set as the desired stimulation target for programming. This sweet spot and estimations of the volume of tissue activated were used to suggest (i) the best lead level, (ii) the best contact, and (iii) the effect thresholds for full therapeutic effect for each contact. To assess these sweet spot-guided suggestions, the clinical monopolar reviews were considered as ground truth. In addition, the sweet spot-guided suggestions for best lead level and best contact were compared against reconstruction-guided suggestions, which considered the lead location with respect to the subthalamic nucleus. Finally, a graphical user interface was developed as an add-on to Lead-DBS and is publicly available. With the interface, suggestions for all contacts of a lead can be generated in a few seconds. The accuracy for suggesting the best out of four lead levels was 56%. These sweet spot-guided suggestions were not significantly better than reconstruction-guided suggestions (p = 0.3). The accuracy for suggesting the best out of eight contacts was 41%. These sweet spot-guided suggestions were significantly better than reconstruction-guided suggestions (p < 0.001). The sweet spot-guided suggestions of each contact’s effect threshold had a mean error of 1.2 mA. On an individual lead level, the suggestions can vary more with mean errors ranging from 0.3 to 4.8 mA. Further analysis is warranted to improve the sweet spot-guided suggestions and to account for more symptoms and stimulation-induced side effects.
- Published
- 2022
- Full Text
- View/download PDF
35. Subthalamic and pallidal deep brain stimulation for Parkinson’s disease—meta-analysis of outcomes
- Author
-
M. Lenard Lachenmayer, Melina Mürset, Nicolas Antih, Ines Debove, Julia Muellner, Maëlys Bompart, Janine-Ai Schlaeppi, Andreas Nowacki, Hana You, Joan P. Michelis, Alain Dransart, Claudio Pollo, Guenther Deuschl, and Paul Krack
- Subjects
Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Abstract Although deep brain stimulation (DBS) of the globus pallidus internus (GPi) and the subthalamic nucleus (STN) has become an established treatment for Parkinson’s disease (PD), a recent meta-analysis of outcomes is lacking. To address this gap, we performed a meta-analysis of bilateral STN- and GPi-DBS studies published from 1990-08/2019. Studies with ≥10 subjects reporting Unified Parkinson’s Disease Rating Scale (UPDRS) III motor scores at baseline and 6–12 months follow-up were included. Several outcome variables were analyzed and adverse events (AE) were summarized. 39 STN studies (2035 subjects) and 5 GPi studies (292 subjects) were eligible. UPDRS-II score after surgery in the stimulation-ON/medication-OFF state compared to preoperative medication-OFF state improved by 47% with STN-DBS and 18.5% with GPi-DBS. UPDRS-III score improved by 50.5% with STN-DBS and 29.8% with GPi-DBS. STN-DBS improved dyskinesia by 64%, daily OFF time by 69.1%, and quality of life measured by PDQ-39 by 22.2%, while Levodopa Equivalent Daily Dose (LEDD) was reduced by 50.0%. For GPi-DBS information regarding dyskinesia, OFF time, PDQ-39 and LEDD was insufficient for further analysis. Correlation analysis showed that preoperative L-dopa responsiveness was highly predictive of the STN-DBS motor outcome across all studies. Most common surgery-related AE were infection (5.1%) and intracranial hemorrhage (3.1%). Despite a series of technological advances, outcomes of modern surgery are still comparable with those of the early days of DBS. Recent changes in target selection with a preference of GPi in elderly patients with cognitive deficits and more psychiatric comorbidities require more published data for validation.
- Published
- 2021
- Full Text
- View/download PDF
36. An Overview of Wearable Haptic Technologies and Their Performance in Virtual Object Exploration
- Author
-
Myla van Wegen, Just L. Herder, Rolf Adelsberger, Manuela Pastore-Wapp, Erwin E. H. van Wegen, Stephan Bohlhalter, Tobias Nef, Paul Krack, and Tim Vanbellingen
- Subjects
object exploration ,object interaction ,virtual reality ,haptics ,wearable ,VR system ,Chemical technology ,TP1-1185 - Abstract
We often interact with our environment through manual handling of objects and exploration of their properties. Object properties (OP), such as texture, stiffness, size, shape, temperature, weight, and orientation provide necessary information to successfully perform interactions. The human haptic perception system plays a key role in this. As virtual reality (VR) has been a growing field of interest with many applications, adding haptic feedback to virtual experiences is another step towards more realistic virtual interactions. However, integrating haptics in a realistic manner, requires complex technological solutions and actual user-testing in virtual environments (VEs) for verification. This review provides a comprehensive overview of recent wearable haptic devices (HDs) categorized by the OP exploration for which they have been verified in a VE. We found 13 studies which specifically addressed user-testing of wearable HDs in healthy subjects. We map and discuss the different technological solutions for different OP exploration which are useful for the design of future haptic object interactions in VR, and provide future recommendations.
- Published
- 2023
- Full Text
- View/download PDF
37. Correction to: Toward understanding the self-adaptive dynamics of a harmonically forced beam with a sliding mass
- Author
-
Krack, Malte, Aboulfotoh, Noha, Twiefel, Jens, Wallaschek, Jörg, Bergman, Lawrence A., and Vakakis, Alexander F.
- Published
- 2021
- Full Text
- View/download PDF
38. Correction to: Explanation of the self-adaptive dynamics of a harmonically forced beam with a sliding mass
- Author
-
Müller, Florian and Krack, Malte
- Published
- 2021
- Full Text
- View/download PDF
39. A randomized controlled double-blind study of rotigotine on neuropsychiatric symptoms in de novo PD
- Author
-
A. Castrioto, S. Thobois, M. Anheim, J. L. Quesada, E. Lhommée, H. Klinger, A. Bichon, E. Schmitt, F. Durif, J. P. Azulay, J. L. Houeto, N. Longato, C. Philipps, P. Pelissier, E. Broussolle, E. Moro, C. Tranchant, V. Fraix, P. Krack, and for the Honeymoon study group
- Subjects
Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Abstract Management of apathy, depression and anxiety in Parkinson’s disease (PD) represents a challenge. Dopamine agonists have been suggested to be effective. This multicenter, randomized (1:1), double-blind study assessed the 6-month effect of rotigotine versus placebo on apathy, depression and anxiety in de novo PD. The primary outcome was the change of apathy, measured with the LARS. The secondary outcomes were the change in depression and anxiety, measured with BDI-2 and STAI-trait and state. Forty-eight drug-naive PD patients were included. The primary outcome was not reached, with a surprisingly high placebo effect on apathy (60%). There was no significant difference in the change of depression at 6 months between rotigotine and placebo. Trait-anxiety was significantly improved by rotigotine compared to placebo (p = 0.04). Compared to placebo, low dose rotigotine significantly improved trait anxiety, but not apathy and depression. The major placebo effect on apathy points towards the importance of a multidisciplinary and tight follow-up in the management of neuropsychiatric symptoms.
- Published
- 2020
- Full Text
- View/download PDF
40. Subthalamic and pallidal deep brain stimulation for Parkinson’s disease—meta-analysis of outcomes
- Author
-
Lachenmayer, M. Lenard, Mürset, Melina, Antih, Nicolas, Debove, Ines, Muellner, Julia, Bompart, Maëlys, Schlaeppi, Janine-Ai, Nowacki, Andreas, You, Hana, Michelis, Joan P., Dransart, Alain, Pollo, Claudio, Deuschl, Guenther, and Krack, Paul
- Published
- 2021
- Full Text
- View/download PDF
41. Association of Rare Genetic Variants in Opioid Receptors with Tourette Syndrome
- Author
-
Christel Depienne, Sorana Ciura, Oriane Trouillard, Delphine Bouteiller, Elsa Leitã;o, Caroline Nava, Boris Keren, Yannick Marie, Justine Guegan, Sylvie Forlani, Alexis Brice, Mathieu Anheim, Yves Agid, Paul Krack, Philippe Damier, François Viallet, Jean-Luc Houeto, Franck Durif, Marie Vidailhet, Yulia Worbe, Emmanuel Roze, Edor Kabashi, and Andreas Hartmann
- Subjects
tourette syndrome ,gene ,variant ,susceptibility factor ,opioid receptor ,zebrafish ,oprk1 ,Diseases of the musculoskeletal system ,RC925-935 ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Background: Genes involved in Tourette syndrome (TS) remain largely unknown. We aimed to identify genetic factors contributing to TS in a French cohort of 120 individuals using a combination of hypothesis-driven and exome-sequencing approaches. Methods: We first sequenced exons of SLITRK1-6 and HDC in the TS cohort and subsequently sequenced the exome of 12 individuals harboring rare variants in these genes to find additional rare variants contributing to the disorder under the hypothesis of oligogenic inheritance. We further screened three candidate genes (OPRK1, PCDH10, and NTSR2) preferentially expressed in the basal ganglia, and three additional genes involved in neurotensin and opioid signaling (OPRM1, NTS, and NTSR1), and compared variant frequencies in TS patients and 788 matched control individuals. We also investigated the impact of altering the expression of Oprk1 in zebrafish. Results: Thirteen ultrarare missense variants of SLITRK1-6 and HDC were identified in 12 patients. Exome sequencing in these patients revealed rare possibly deleterious variants in 3,041 genes, 54 of which were preferentially expressed in the basal ganglia. Comparison of variant frequencies altering selected candidate genes in TS and control individuals revealed an excess of potentially disrupting variants in OPRK1, encoding the opioid kappa receptor, in TS patients. Accordingly, we show that downregulation of the Oprk1 orthologue in zebrafish induces a hyperkinetic phenotype in early development. Discussion: These results support a heterogeneous and complex genetic etiology of TS, possibly involving rare variants altering the opioid pathway in some individuals, which could represent a novel therapeutic target in this disorder.
- Published
- 2019
- Full Text
- View/download PDF
42. Maladaptive One-Leg Balance Control in Parkinson’s Disease
- Author
-
Eric Chevrier, Elena Moro, Pierre Pelissier, Anna Castrioto, Paul Krack, Valérie Fraix, and Bettina Debû
- Subjects
asymmetry ,balance ,Parkinson’s disease ,rehabilitation ,Mathematics ,QA1-939 - Abstract
Balance disorders are very frequent in Parkinson’s disease (PD). One-leg stance performance is a predictor of fall risk. We investigated one-leg stance strategies in people with PD. We hypothesized that patients would choose, and better perform on, the leg on the least affected body side. Fifty participants with 2 to 19 years of PD duration stood on one leg while ON medication. The leg spontaneously chosen was recorded. Performance was compared between the spontaneously chosen vs. contralateral, and most vs. least stable legs. Influence of disease duration, severity, age, cognition, and motor fluctuations was analyzed. Twenty-eight patients spontaneously stood on the leg of the least affected body side, which was not always the most stable one. The chosen standing leg was influenced by disease duration with a switch between the least vs. most affected body side after seven years of disease duration. Fourteen patients (28%) spontaneously stood on their least stable leg. Thus, some patients with PD choose the least stable leg when asked to perform one-leg stance. It is important to identify these patients since they may be at greater risk of falls and/or gait difficulties. Specific rehabilitation may help prevent such maladaptive strategy.
- Published
- 2022
- Full Text
- View/download PDF
43. Explanation of the self-adaptive dynamics of a harmonically forced beam with a sliding mass
- Author
-
Müller, Florian and Krack, Malte
- Published
- 2020
- Full Text
- View/download PDF
44. Consensus Statement on High-Intensity Focused Ultrasound for Functional Neurosurgery in Switzerland
- Author
-
Lennart H. Stieglitz, Markus F. Oertel, Ettore A. Accolla, Julien Bally, Roland Bauer, Christian R. Baumann, David Benninger, Stephan Bohlhalter, Fabian Büchele, Stefan Hägele-Link, Georg Kägi, Paul Krack, Marie T. Krüger, Sujitha Mahendran, J. Carsten Möller, Veit Mylius, Tobias Piroth, Beat Werner, and Alain Kaelin-Lang
- Subjects
focused ultrasound ,HIFUS ,MRgHiFUS ,consensus ,movement disorders ,Parkinson ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Background: Magnetic resonance-guided high-intensity focused ultrasound (MRgHiFUS) has evolved into a viable ablative treatment option for functional neurosurgery. However, it is not clear yet, how this new technology should be integrated into current and established clinical practice and a consensus should be found about recommended indications, stereotactic targets, patient selection, and outcome measurements.Objective: To sum up and unify current knowledge and clinical experience of Swiss neurological and neurosurgical communities regarding MRgHiFUS interventions for brain disorders to be published as a national consensus paper.Methods: Eighteen experienced neurosurgeons and neurologists practicing in Switzerland in the field of movement disorders and one health physicist representing 15 departments of 12 Swiss clinical centers and 5 medical societies participated in the workshop and contributed to the consensus paper. All experts have experience with current treatment modalities or with MRgHiFUS. They were invited to participate in two workshops and consensus meetings and one online meeting. As part of workshop preparations, a thorough literature review was undertaken and distributed among participants together with a list of relevant discussion topics. Special emphasis was put on current experience and practice, and areas of controversy regarding clinical application of MRgHiFUS for functional neurosurgery.Results: The recommendations addressed lesioning for treatment of brain disorders in general, and with respect to MRgHiFUS indications, stereotactic targets, treatment alternatives, patient selection and management, standardization of reporting and follow-up, and initialization of a national registry for interventional therapies of movement disorders. Good clinical evidence is presently only available for unilateral thalamic lesioning in treating essential tremor or tremor-dominant Parkinson's disease and, to a minor extent, for unilateral subthalamotomy for Parkinson's disease motor features. However, the workgroup unequivocally recommends further exploration and adaptation of MRgHiFUS-based functional lesioning interventions and confirms the need for outcome-based evaluation of these approaches based on a unified registry. MRgHiFUS and DBS should be evaluated by experts familiar with both methods, as they are mutually complementing therapy options to be appreciated for their distinct advantages and potential.Conclusion: This multidisciplinary consensus paper is a representative current recommendation for safe implementation and standardized practice of MRgHiFUS treatments for functional neurosurgery in Switzerland.
- Published
- 2021
- Full Text
- View/download PDF
45. Programming parameters of subthalamic deep brain stimulators in Parkinson's disease from a controlled trial
- Author
-
Knudsen, K., Krack, P., Tonder, L., Houeto, J.-L., Rau, J., Schade-Brittinger, C., Hartmann, A., Hälbig, Thomas D., Paschen, Stephen, Barbe, Michael T., Kühn, Andrea, Fraix, Valerie, Brefel-Courbon, Christine, Vesper, Jan, Maltête, David, Sixel-Döring, Friederike, Weiss, Daniel, Witjas, Tatiana, Thobois, Stephane, Agid, Yves, Schnitzler, A., Schuepbach, W.M.M., Timmermann, L., Damier, Philippe, Vidailhet, M., and Deuschl, G.
- Published
- 2019
- Full Text
- View/download PDF
46. Pulmonary arterial hypertension patients display normal kinetics of clot formation using thrombelastography
- Author
-
Mengyun Lu, Kevin P. Blaine, Ann Cullinane, Courtney Hall, Alina Dulau-Florea, Junfeng Sun, Herman F. Chenwi, Grace M. Graninger, Bonnie Harper, Keshia Thompson, Janell Krack, Christopher F. Barnett, Samuel B. Brusca, Jason M. Elinoff, and Michael A. Solomon
- Subjects
Diseases of the circulatory (Cardiovascular) system ,RC666-701 ,Diseases of the respiratory system ,RC705-779 - Abstract
Pulmonary arterial hypertension is characterized by endothelial dysfunction and microthrombi formation. The role of anticoagulation remains controversial, with studies demonstrating inconsistent effects on pulmonary arterial hypertension mortality. Clinical anticoagulation practices are currently heterogeneous, reflecting physician preference. This study uses thrombelastography and hematology markers to evaluate whether clot formation and fibrinolysis are abnormal in pulmonary arterial hypertension patients. Venous blood was collected from healthy volunteers ( n = 20) and patients with pulmonary arterial hypertension ( n = 20) on stable medical therapy for thrombelastography analysis. Individual thrombelastography parameters and a calculated coagulation index were used for comparison. In addition, hematologic markers, including fibrinogen, factor VIII activity, von Willebrand factor activity, von Willebrand factor antigen, and alpha2-antiplasmin, were measured in pulmonary arterial hypertension patients and compared to healthy volunteers. Between group differences were analyzed using t tests and linear mixed models, accounting for repeated measures when applicable. Although the degree of fibrinolysis (LY30) was significantly lower in pulmonary arterial hypertension patients compared to healthy volunteers (0.3% ± 0.6 versus 1.3% ± 1.1, p = 0.04), all values were within the normal reference range (0–8%). All other thrombelastography parameters were not significantly different between pulmonary arterial hypertension patients and healthy volunteers ( p ≥ 0.15 for all). Similarly, alpha2-antiplasmin activity levels were higher in pulmonary arterial hypertension patients compared to healthy volunteers (103.7% ± 13.6 versus 82.6% ± 9.5, p
- Published
- 2021
- Full Text
- View/download PDF
47. Stability and Speciation of Hydrated Magnetite {111} Surfaces from Ab Initio Simulations with Relevance for Geochemical Redox Processes.
- Author
-
Katheras, Anita S., Karalis, Konstantinos, Krack, Matthias, Scheinost, Andreas C., and Churakov, Sergey V.
- Published
- 2024
- Full Text
- View/download PDF
48. Neurobiology and clinical features of impulse control failure in Parkinson’s disease
- Author
-
Matthieu Béreau, Paul Krack, Norbert Brüggemann, and Thomas F. Münte
- Subjects
Parkinson’s disease ,Impulse control disorders ,Behavioral addictions ,Dopamine ,Neuropsychiatric fluctuations ,Mesocorticolimbic sensitization ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Abstract Impulse control disorders (ICDs) and other impulsive-compulsive related behaviours are frequent and still under recognized non-motor complications of Parkinson’s disease (PD). They result from sensitization of the mesocorticolimbic pathway that arose in predisposed PD patients concomitantly with spreading of PD pathology, non-physiological dopaminergic and pulsatile administration of dopamine replacement therapy (DRT). Neuropsychiatric fluctuations (NPF) reflect the psychotropic effects of dopaminergic drugs and play a crucial role in the emergence of ICDs and behavioral addictions. Dopamine agonists (DA) which selectively target D2 and D3 receptors mostly expressed within the mesocorticolimbic pathway, are the main risk factor to develop ICDs. Neuroimaging studies suggest that dopamine agonists lead to a blunted response of the brain’s reward system both during reward delivery and anticipation. Genetic predispositions are crucial for the responsiveness of the mesolimbic system and the development of ICDs with several genes having been identified. Early screening for neuropsychiatric fluctuations, reduction of DA, fractionating levodopa dosage, education of patients and their relatives, are the key strategies for diagnosis and management of ICDs and related disorders.
- Published
- 2019
- Full Text
- View/download PDF
49. How to make value-based health insurance designs more effective? A systematic review and meta-analysis
- Author
-
Krack, Gundula
- Published
- 2019
- Full Text
- View/download PDF
50. Biomarkers for closed-loop deep brain stimulation in Parkinson disease and beyond
- Author
-
Bouthour, Walid, Mégevand, Pierre, Donoghue, John, Lüscher, Christian, Birbaumer, Niels, and Krack, Paul
- Published
- 2019
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.