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3. Tertiary lymphoid structures and B cells determine clinically relevant T cell phenotypes in ovarian cancer

Author

Kasikova, Lenka, Rakova, Jana, Hensler, Michal, Lanickova, Tereza, Tomankova, Jana, Pasulka, Josef, Drozenova, Jana, Mojzisova, Katerina, Fialova, Anna, Vosahlikova, Sarka, Laco, Jan, Ryska, Ales, Dundr, Pavel, Kocian, Roman, Brtnicky, Tomas, Skapa, Petr, Capkova, Linda, Kovar, Marek, Prochazka, Jan, Praznovec, Ivan, Koblizek, Vladimir, Taskova, Alice, Tanaka, Hisashi, Lischke, Robert, Mendez, Fernando Casas, Vachtenheim, Jr, Jiri, Heinzelmann-Schwarz, Viola, Jacob, Francis, McNeish, Iain A., Halaska, Michal J., Rob, Lukas, Cibula, David, Orsulic, Sandra, Galluzzi, Lorenzo, Spisek, Radek, and Fucikova, Jitka

Published
2024
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4. Genetic sex validation for sample tracking in next-generation sequencing clinical testing

Author

Hu, Jianhong, Korchina, Viktoriya, Zouk, Hana, Harden, Maegan V., Murdock, David, Macbeth, Alyssa, Harrison, Steven M., Lennon, Niall, Kovar, Christie, Balasubramanian, Adithya, Zhang, Lan, Chandanavelli, Gauthami, Pasham, Divya, Rowley, Robb, Wiley, Ken, Smith, Maureen E., Gordon, Adam, Jarvik, Gail P., Sleiman, Patrick, Kelly, Melissa A., Bland, Harris T., Murugan, Mullai, Venner, Eric, Boerwinkle, Eric, Prows, Cynthia, Mahanta, Lisa, Rehm, Heidi L., Gibbs, Richard A., and Muzny, Donna M.

Published
2024
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15. Factors Influencing Socially Responsible Leadership Development in College of Agriculture Students

Author

Kovar, Kristin A. and Simonsen, Jon C.

Abstract

The purpose of this study was to examine factors impacting college student leadership development within a college of agriculture at the University of Missouri. This study employed descriptive relational survey methods to examine the impact of involvement factors (participation in organizations, community service and leadership education) on college student leadership development. The target population was all junior and senior students in the College of Agricutlure, Food and Natural Resources at the University of Missouri (N=1,124). Out of the calculated sample size (n=287), 107 participants completed the online instrument (37.3%). In the examination of the leadership outcomes, the greatest mean was reported for the outcome of commitment and the lowest mean was reported for the outcome of change. Most students were involved with two to five different organizations during their college career. A majority (92.5%) of the students reported that they have engaged in community service during their college career, although 44.9% of respondents did not participate in community service on a regular basis. Students responded as being involved in one to two short-term leadership education programs, but no long-term leadership education programs. Eight separate linear regression models were analyzed to determine the impact of involvement factors on the development of socially responsible leadership.

Published
2019

16. Emotional Intelligence in Undergraduate Medical Students: A Scoping Review

Author

Toriello, Helga V., Van de Ridder, J. M. Monica, Brewer, Patricia, Mavis, Brian, Allen, Renoulte, Arvidson, Cindy, Kovar-Gough, Iris, Novak, Elizabeth, O'Donnell, John, Osuch, Janet, and Ulrich, Brian

Abstract

Purpose: To perform a scoping review to determine what is known about emotional intelligence (EI) in undergraduate medical education (UME). Two main questions were asked: (1) What medical student characteristics are associated with EI? Are there correlations with demographic or other factors?; and (2) What research studies have been done on EI in UME? For example, is there evidence EI changes over time as a result of personal experiences? Should EI be used as an admission criterion? Can EI improve as a result of experiences or deliberate interventions? Method: The authors searched four databases (PubMed, PsycInfo, Education Resources Information Center, and Web of Science) for all papers published up to and including December 2020. Two reviewers independently screened articles to determine if they met inclusion criteria. All authors extracted and analyzed data. Results: A set of 1520 papers on the topic of emotional intelligence was identified, with 119 papers meeting inclusion criteria. Most studies were done at international locations with only 17 done at US medical schools. Seventy-five were cohort or cross-sectional studies. Study populations were mixed among the studies, with year of medical study, inclusion of other healthcare students, and participation rates among the inter-study differences noted. Conclusions: Numerous gaps in the literature on EI exist with several points being clear: (1) there is disagreement on the definition of EI; (2) it is undetermined whether EI is a trait or an ability; and (3) there is marked variability among the instruments used to measure EI. It is also becoming apparent that using EI determination may be helpful as a component of the admission process, higher EI is likely related to improved clinical reasoning, and higher EI contributes to more effective stress management.

Published
2022
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21. An international working group consensus report for the prioritization of molecular biomarkers for Ewing sarcoma

Author

Shulman, David S., Whittle, Sarah B., Surdez, Didier, Bailey, Kelly M., de Álava, Enrique, Yustein, Jason T., Shlien, Adam, Hayashi, Masanori, Bishop, Alexander J. R., Crompton, Brian D., DuBois, Steven G., Shukla, Neerav, Leavey, Patrick J., Lessnick, Stephen L., Kovar, Heinrich, Delattre, Olivier, Grünewald, Thomas G. P., Antonescu, Cristina R., Roberts, Ryan D., Toretsky, Jeffrey A., Tirode, Franck, Gorlick, Richard, Janeway, Katherine A., Reed, Damon, Lawlor, Elizabeth R., and Grohar, Patrick J.

Published
2022
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28. Fire Salamander, Salamandra salamandra, niche selection in Central European conditions.

Author

KOVAR, ROMAN, BRABEC, MAREK, MORAVEC, PAVEL, and HUSAK, TOMAS

Abstract

We analyzed data from 3,546 occurrence records of Fire Salamanders (Salamandra salamandra) from the territory of the Czech Republic where it has a heterogeneous distribution pattern. Its occurrence in terrestrial habitats adjacent to breeding streams is characterized by a mean distance of 103 m, maximum 1,321 m, from the nearest stream. Based on a logistic GLM (generalized linear model) analysis we determined the Fire Salamanders' climatic and habitat associations at landscape scale in the Czech Republic. The main limiting factors for its dispersal include the proximity of small shallow streams in rolling landscapes, the pH of these streams, the presence of broad-leaf or mixed forests, humidity, solar irradiation, and severity of winters. While the absence of suitable breeding habitats is the main limiting factor for their occurrence in more expansive lowlands, factors such as lower temperatures, lower humidity, and the absence of broad-leaf and mixed forests begin to play a role with increasing altitude. Unlike cold temperatures, low amounts of precipitation and higher temperatures do not act as limiters in the Czech Republic. Fire Salamanders respond to the colder climate of higher altitudes with intensified summer activity and the purely bimodal nature of their activity (with spring and autumn peaks) tends to fade at higher altitudes. [ABSTRACT FROM AUTHOR]

Published
2024

29. Two Decades of Agricultural Literacy Research: A Synthesis of the Literature

Author

Kovar, Kristin A. and Ball, Anna L.

Abstract

The purpose of this investigation was to identify and synthesize research related to agricultural literacy since the publication of Understanding Agriculture--New Directions for Education (1988). The researchers sought to determine where agricultural literacy research was published, which populations were targeted, the purpose of the research, and the findings of agricultural literacy studies published between 1988 and 2011. Overall, a total of 49 studies were found - 17 studies in the Journal of Agricultural Education, seven studies in the NACTA Journal, three studies in the Journal of Extension, 18 studies in national or regional American Association for Agricultural Education (AAAE) conference proceedings, and four miscellaneous studies. The populations targeted in agricultural literacy research were teachers, students, and non-educator adults with elementary teachers and students being the most frequently targeted populations. The purposes of the respective studies were coded into three specific areas: (a) assess agricultural literacy; (b) test the effectiveness of an agricultural literacy program; or (c) develop a framework or guide used to assist educators. While the programs were found to be successful in increasing agricultural literacy, many populations assessed were found to be agriculturally illiterate. Further research is warranted to explain areas of deficiency in agricultural literacy.

Published
2013

30. Author Correction: Comparative and demographic analysis of orang-utan genomes

Author

Locke, Devin P., Hillier, LaDeana W., Warren, Wesley C., Worley, Kim C., Nazareth, Lynne V., Muzny, Donna M., Yang, Shiaw-Pyng, Wang, Zhengyuan, Chinwalla, Asif T., Minx, Pat, Mitreva, Makedonka, Cook, Lisa, Delehaunty, Kim D., Fronick, Catrina, Schmidt, Heather, Fulton, Lucinda A., Fulton, Robert S., Nelson, Joanne O., Magrini, Vincent, Pohl, Craig, Graves, Tina A., Markovic, Chris, Cree, Andy, Dinh, Huyen H., Hume, Jennifer, Kovar, Christie L., Fowler, Gerald R., Lunter, Gerton, Meader, Stephen, Heger, Andreas, Ponting, Chris P., Marques-Bonet, Tomas, Alkan, Can, Chen, Lin, Cheng, Ze, Kidd, Jeffrey M., Eichler, Evan E., White, Simon, Searle, Stephen, Vilella, Albert J., Chen, Yuan, Flicek, Paul, Ma, Jian, Raney, Brian, Suh, Bernard, Burhans, Richard, Herrero, Javier, Haussler, David, Faria, Rui, Fernando, Olga, Darré, Fleur, Farré, Domènec, Gazave, Elodie, Oliva, Meritxell, Navarro, Arcadi, Roberto, Roberta, Capozzi, Oronzo, Archidiacono, Nicoletta, Della Valle, Giuliano, Purgato, Stefania, Rocchi, Mariano, Konkel, Miriam K., Walker, Jerilyn A., Ullmer, Brygg, Batzer, Mark A., Smit, Arian F. A., Hubley, Robert, Casola, Claudio, Schrider, Daniel R., Hahn, Matthew W., Quesada, Victor, Puente, Xose S., Ordoñez, Gonzalo R., López-Otín, Carlos, Vinar, Tomas, Brejova, Brona, Ratan, Aakrosh, Harris, Robert S., Miller, Webb, Kosiol, Carolin, Lawson, Heather A., Taliwal, Vikas, Martins, André L., Siepel, Adam, RoyChoudhury, Arindam, Ma, Xin, Degenhardt, Jeremiah, Bustamante, Carlos D., Gutenkunst, Ryan N., Mailund, Thomas, Dutheil, Julien Y., Hobolth, Asger, Schierup, Mikkel H., Ryder, Oliver A., Yoshinaga, Yuko, de Jong, Pieter J., Weinstock, George M., Rogers, Jeffrey, Mardis, Elaine R., Gibbs, Richard A., and Wilson, Richard K.

Published
2022
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43. Gender Bias in Early Childhood Education.

Author

Kovar, Patricia McAfee and Doty, LuEllen

Abstract

Noting that both boys and girls suffer because of gender bias in society and in the classroom, this paper examines the roots and consequences of such bias. The paper first provides a historical overview of gender bias and its relation to the prevalent world view. Next, it examines the manifestations of gender bias in the classroom and their effects on learning and self esteem for both boys and girls. Girls start out ahead of boys in speaking, reading, and counting skill evaluations, but these scores decline while boys' scores rise. Strategies are suggested to minimize gender bias, especially in early childhood and primary education. It is recommended that schools give attention to alleviating gender bias for both boys and girls by offering equal career opportunities. Societal values play a significant role in the interpretation of the results of gender bias throughout society, and all people deserve a bias free education. An annotated bibliography of materials on gender bias in education is included. (AP)

Published
1994

45. Phase I/II open-label study of the biologic effects of the interleukin-2 immunocytokine EMD 273063 (hu14.18-IL2) in patients with metastatic malignant melanoma

Author

Ribas, Antoni, Kirkwood, John M, Atkins, Michael B, Whiteside, Theresa L, Gooding, William, Kovar, Andreas, Gillies, Stephen D, Kashala, Oscar, and Morse, Michael A

Abstract

Abstract Background To explore the biological activity of EMD 273063 (hu14.18-IL2), a humanized anti-GD2 monoclonal antibody fused to interleukin-2 (IL2), in patients with unresectable, stage IV cutaneous melanoma as measured by induction of immune activation at the tumor site and in peripheral blood. Methods Nine patients were treated with 4 mg/m2 per day of EMD 273063 given as a 4-h intravenous infusion on days 1, 2, and 3 every four weeks (one cycle). Peripheral blood was analyzed for T cell and natural killer cell phenotype and frequency, as well as levels of soluble IL2 receptor (sIL2R), IL10, IL6, tumor necrosis factor alpha and neopterin. Biopsies of tumor metastasis were performed prior to therapy and at day 10 of the first 2 cycles to study lymphocyte accumulation by immunohistochemistry. Results Treatment was generally well tolerated and there were no study drug-related grade 4 adverse events. Grade 3 events were mainly those associated with IL2, most commonly rigors (3 patients) and pyrexia (2 patients). Best response on therapy was stable disease in 2 patients. There were no objective tumor regressions by standard response criteria. Systemic immune activation was demonstrated by increases in serum levels of sIL2R, IL10, and neopterin. There was evidence of increased tumor infiltration by T cells, but not NK cells, in most post-dosing biopsies, suggesting recruitment of immune cells to the tumor site. Conclusion EMD 273063 demonstrated biologic activity with increased immune-related cytokines and intratumoral changes in some patients consistent with the suspected mechanism of action of this immunocytokine.

Published
2009

46. Qualitative Evaluation in Higher Education.

Author

Ermler, Kathy and Kovar, Susan

Abstract

Qualitative evaluation can be used to facilitate change in the immediate higher education professional environment. This evaluation method enriches the collection and interpretation of data by involving all groups and persons who have a share in the problem. In contrast to qualitative research, qualitative evaluation assists in situation-specific decision-making and attempts to involve all individuals and groups associated with the problem in all phases of data collection and interpretation. A model for qualitative evaluation used by Guba and Lincoln consists of nine steps: (1) identify the problem (any individual or member of a group can identify a problem); (2) identify shareholders (identify all who are associated with or could be effected by the issue); (3) focus responsively (generating alternative problem statements); (4) prioritize questions, concerns, and issues (group representatives together discuss the questions generated in Step 3); (5) identify information and identify criteria (deciding what data to collect, choosing criteria to evaluate the data); (6) collect data (data collection not be limited to a single instrument, method or person/group); (7) present information and prepare agenda for negotiation (each group prepares an agenda concerning their preferred solution); (8) negotiate solutions (group representatives together arrive at a compromise solution); and (9) develop report or written action plan. (JB)

Published
1990

47. Dental cell type atlas reveals stem and differentiated cell types in mouse and human teeth

Author

Krivanek, Jan, Soldatov, Ruslan A., Kastriti, Maria Eleni, Chontorotzea, Tatiana, Herdina, Anna Nele, Petersen, Julian, Szarowska, Bara, Landova, Marie, Matejova, Veronika Kovar, Holla, Lydie Izakovicova, Kuchler, Ulrike, Zdrilic, Ivana Vidovic, Vijaykumar, Anushree, Balic, Anamaria, Marangoni, Pauline, Klein, Ophir D., Neves, Vitor C. M., Yianni, Val, Sharpe, Paul T., Harkany, Tibor, Metscher, Brian D., Bajénoff, Marc, Mina, Mina, Fried, Kaj, Kharchenko, Peter V., and Adameyko, Igor

Published
2020
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48. Compressor cascade correlations modelling at design points using artificial neural networks.

Author

Kovar, P. and Furst, J.

Subjects
ARTIFICIAL neural networks, DEEP learning, COMPUTATIONAL fluid dynamics, COMPRESSORS, PERCEPTRONS, AEROFOILS
Abstract

In recent years, the flow analysis by means of computational fluid dynamics (CFD) has become a useful design and optimization tool. Unfortunately, despite advances in the computational power, numerical simulations are still very time consuming. Thus, empirical correlation models keep their importance as a tool for early stages of axial compressor design and for prediction of basic performance parameters. These correlations were developed based on experimental data obtained from 2D measurements performed on cases of classical airfoils such as the NACA 65-series or C.4 profiles. There is insufficient amount of experimental data for other families of airfoils, but CFD simulations can be used instead and their results correlated using artificial neural networks (ANN), as described in this work. Unlike the classical deep learning approach using perceptrons, this work presents neural networks employing higher order neural units. [ABSTRACT FROM AUTHOR]

Published
2023
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