333 results on '"Kotov R"'
Search Results
2. Health status and mobility limitations are associated with residential and employment status in schizophrenia and bipolar disorder
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Strassnig, M., Cornacchio, D., Harvey, P.D., Kotov, R., Fochtmann, L., and Bromet, E.J.
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- 2017
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3. Personality diatheses and Hurricane Sandy: effects on post-disaster depression
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Kopala-Sibley, D. C., Kotov, R., Bromet, E. J., Carlson, G. A., Danzig, A. P., Black, S. R., and Klein, D. N.
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- 2016
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4. DSM-IV post-traumatic stress disorder among World Trade Center responders 11–13 years after the disaster of 11 September 2001 (9/11)
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Bromet, E. J., Hobbs, M. J., Clouston, S. A. P., Gonzalez, A., Kotov, R., and Luft, B. J.
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- 2016
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5. Familial risk for distress and fear disorders and emotional reactivity in adolescence: an event-related potential investigation
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Nelson, B. D., Perlman, G., Hajcak, G., Klein, D. N., and Kotov, R.
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- 2015
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6. The structure and short-term stability of the emotional disorders: a dimensional approach
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Kotov, R., Perlman, G., Gámez, W., and Watson, D.
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- 2015
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7. Contributions of common genetic variants to risk of schizophrenia among individuals of African and Latino ancestry
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Macedo, A., Evgrafov, O.V., McCarroll, S.A., Marder, S.R., Vawter, M.P., Bromet, E.J., Sullivan, P.F., Purcell, S.M., Azevedo, M.H., Kotov, R., Rakofsky, J.J., Nicolini, H., Moran, J.L., Pato, M.T., Genovese, G., Dumont, A.L., Fochtmann, L.J., Braff, D.L., Smoller, J.W., Peterson, R.E., Bigdeli, T.B, Chapman, S.B., Rapaport, M.H., Belliveau, R.A., Kennedy, J.L., Achtyes, E.D., O'Dushlaine, C., Nemesh, J., Sklar, B.M., Medeiros, H., Perkins, D.O., Sklar, P., Iyegbe, C.O., Escamilla, M.A., Bevilacqua, E., Knowles, J.A., Scolnick, E.M., Morley, C.P., Carvalho, C.B., Sobell, J.L., Genomic Psychiatry Cohort (GPC) Consortium, Malaspina, D., Lehrer, D.S., Gage, D., DeLisi, L.E., Macciardi, F., Dewan, M.J., Meyers, J.L., Consortium on the Genetics of Schizophrenia (COGS) Investigators, Abbott, C., Kinkead, B., Georgakopoulos, P., Gur, R.E., Stahl, E.A., Gur, R.C., Valderrama, J., Buckley, P.F., Byerley, W., and Pato, C.N.
- Abstract
Schizophrenia is a common, chronic and debilitating neuropsychiatric syndrome affecting tens of millions of individuals worldwide. While rare genetic variants play a role in the etiology of schizophrenia, most of the currently explained liability is within common variation, suggesting that variation predating the human diaspora out of Africa harbors a large fraction of the common variant attributable heritability. However, common variant association studies in schizophrenia have concentrated mainly on cohorts of European descent. We describe genome-wide association studies of 6152 cases and 3918 controls of admixed African ancestry, and of 1234 cases and 3090 controls of Latino ancestry, representing the largest such study in these populations to date. Combining results from the samples with African ancestry with summary statistics from the Psychiatric Genomics Consortium (PGC) study of schizophrenia yielded seven newly genome-wide significant loci, and we identified an additional eight loci by incorporating the results from samples with Latino ancestry. Leveraging population differences in patterns of linkage disequilibrium, we achieve improved fine-mapping resolution at 22 previously reported and 4 newly significant loci. Polygenic risk score profiling revealed improved prediction based on trans-ancestry meta-analysis results for admixed African (Nagelkerke���s R2 = 0.032; liability R2 = 0.017; P < 10���52), Latino (Nagelkerke���s R2 = 0.089; liability R2 = 0.021; P < 10���58), and European individuals (Nagelkerke���s R2 = 0.089; liability R2 = 0.037; P < 10���113), further highlighting the advantages of incorporating data from diverse human populations.
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- 2020
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8. Crystal structure of double vanadates Ca9 R(VO4)7. II. R = Tb, Dy, Ho, and Y
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Belik, A. A., Morozov, V. A., Kotov, R. N., Khasanov, S. S., and Lazoryak, B. I.
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- 2000
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9. Crystal structures of double calcium and alkali metal phosphates Ca10 M(PO4)7(M = Li, Na, K)
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Morozov, V. A., Belik, A. A., Kotov, R. N., Presnyakov, I. A., Khasanov, S. S., and Lazoryak, B. I.
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- 2000
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10. Effects of Amikacin on Maturation of the Auditory Analyzer in Rabbits
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D’yakonova, I. N., Rakhmanova, I. V., Tikhomirov, A. M., Ishanova, Yu. S., and Kotov, R. V.
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- 2011
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11. Exposure, probable PTSD and lower respiratory illness among World Trade Center rescue, recovery and clean-up workers
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Luft, B. J., Schechter, C., Kotov, R., Broihier, J., Reissman, D., Guerrera, K., Udasin, I., Moline, J., Harrison, D., Friedman-Jimenez, G., Pietrzak, R. H., Southwick, S. M., and Bromet, E. J.
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- 2012
12. The Chornobyl accident and cognitive functioning: a follow-up study of infant evacuees at age 19 years
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Taormina, D. P., Rozenblatt, S., Guey, L. T., Gluzman, S. F., Carlson, G. A., Havenaar, J. M., Zakhozha, V., Kotov, R., and Bromet, E. J.
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- 2008
13. The mental health of clean-up workers 18 years after the Chernobyl accident
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Loganovsky, K., Havenaar, J. M., Tintle, N. L., Guey, L. T., Kotov, R., and Bromet, E. J.
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- 2008
14. Redefining phenotypes to advance psychiatric genetics: Implications from hierarchical taxonomy of psychopathology
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Waszczuk, M.A., Eaton, N.R., Krueger, R.F., Shackman, A., Fried, E.I., Kotov, R., Waldman, I.D., Zald, D.H., Lahey, B.B., Patrick, C.J., Conway, C.C., Ormel, J., Hyman, S.E., Fried, E.L., Forbes, M.K., Docherty, A.R., Althoff, R.R., Bach, B., Chmielewski, M., DeYoung, C.G., Forbush, K.T., Hallquist, M., Hopwood, C.J., Ivanova, M.Y., Jonas, K.G., Latzman, R.D., Markon, K.E., Mullins-Sweatt, S.N., Pincus, A.L., Reininghaus, U., South, S.C., Tackett, J.L., Watson, D., Wright, A.G.C., Psychiatrie & Neuropsychologie, and RS: MHeNs - R2 - Mental Health
- Subjects
Nosology ,medicine.medical_specialty ,ENVIRONMENTAL RISK-FACTORS ,DEFICIT HYPERACTIVITY DISORDER ,Psychology, Clinical ,Genome-wide association study ,nosology ,Computational biology ,SUBSTANCE USE DISORDERS ,Article ,Molecular genetics ,medicine ,Genetic Pleiotropy ,Genetics ,Humans ,2.1 Biological and endogenous factors ,Psychology ,behavior genetics ,Genetic Testing ,POLYGENIC RISK ,GENOME-WIDE ASSOCIATION ,general factor ,Biological Psychiatry ,Psychiatric genetics ,Behavioural genetics ,Psychiatry ,Mental Disorders ,Human Genome ,POPULATION-BASED SAMPLE ,EATING-DISORDERS ,MAJOR DEPRESSION ,Twin study ,DSM-IV CRITERIA ,Brain Disorders ,PERSONALITY-DISORDER ,Psychiatry and Mental health ,Clinical Psychology ,comorbidity ,Phenotype ,Mental Health ,molecular genetics ,Cognitive Sciences ,Psychopathology ,Biotechnology - Abstract
Genetic discovery in psychiatry and clinical psychology is hindered by suboptimal phenotypic definitions. We argue that the hierarchical, dimensional, and data-driven classification system proposed by the Hierarchical Taxonomy of Psychopathology (HiTOP) consortium provides a more effective approach to identifying genes that underlie mental disorders, and to studying psychiatric etiology, than current diagnostic categories. Specifically, genes are expected to operate at different levels of the HiTOP hierarchy, with some highly pleiotropic genes influencing higher order psychopathology (e.g., the general factor), whereas other genes conferring more specific risk for individual spectra (e.g., internalizing), subfactors (e.g., fear disorders), or narrow symptoms (e.g., mood instability). We propose that the HiTOP model aligns well with the current understanding of the higher order genetic structure of psychopathology that has emerged from a large body of family and twin studies. We also discuss the convergence between the HiTOP model and findings from recent molecular studies of psychopathology indicating broad genetic pleiotropy, such as cross-disorder SNP-based shared genetic covariance and polygenic risk scores, and we highlight molecular genetic studies that have successfully redefined phenotypes to enhance precision and statistical power. Finally, we suggest how to integrate a HiTOP approach into future molecular genetic research, including quantitative and hierarchical assessment tools for future data-collection and recommendations concerning phenotypic analyses. (PsycINFO Database Record (c) 2020 APA, all rights reserved).
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- 2019
15. Modeling of physical processes at the waist of a Z-pinch
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Glazyrin, I. V., Diyankov, O. V., Kotov, R. A., and Koshelev, S. V.
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- 1995
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16. The Impact of Kuzbass Industrial Enterprises on Environmental Safety.
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Kotov, R M and Formulevich, Ya V
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- 2021
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17. The longitudinal trajectories of social functioning in psychotic disorders
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Fett, A.J., Velthorst, E., Reichenberg, A., Perlman, G., van Os, J., Bromet, E., Kotov, R., LEARN! - Social cognition and learning, and Educational Neuroscience
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- 2016
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18. Associations of life events during pregnancy with longitudinal change in symptoms of antenatal anxiety and depression
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Meijer, J. L., Bockting, C. L. H., Stolk, R. P., Kotov, R., Ormel, J., Burger, H., Trauma and Grief, SGPL Economische Geografie, Laboratory Genetic Metabolic Diseases, Amsterdam Gastroenterology Endocrinology Metabolism, Cancer Center Amsterdam, Adult Psychiatry, APH - Mental Health, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, Clinical Psychology and Experimental Psychopathology, Interdisciplinary Centre Psychopathology and Emotion regulation (ICPE), Life Course Epidemiology (LCE), Reproductive Origins of Adult Health and Disease (ROAHD), and Lifestyle Medicine (LM)
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Adult ,medicine.medical_specialty ,Adolescent ,DISORDERS ,Depression/epidemiology ,Population ,Behavioral Symptoms ,Anxiety ,STRESSORS ,Life Change Events ,Young Adult ,CHILD ,Pregnancy ,Maternity and Midwifery ,medicine ,Humans ,COHORT ,Pregnancy/psychology ,Psychiatry ,education ,Depression (differential diagnoses) ,SCALE ,POPULATION ,education.field_of_study ,Depression ,Obstetrics and Gynecology ,WOMEN ,Middle Aged ,medicine.disease ,Neuroticism ,STATE ,Edinburgh Postnatal Depression Scale ,Female ,medicine.symptom ,Psychology ,Psychosocial ,State-Trait Anxiety Inventory ,Anxiety/epidemiology ,Clinical psychology - Abstract
OBJECTIVE: to investigate the association of life events during pregnancy with change in antenatal anxiety and depression symptoms. We distinguished pregnancy related and non-pregnancy related events and assessed specificity of these associations for depressive or anxious symptoms. In addition, we investigated whether the associations were affected by personality or childhood adversities.DESIGN: observational prospective cohort studySETTING: primary and secondary obstetric care centres in the NetherlandsPARTICIPANTS: 1603 women during their first trimester of pregnancy between May 2010 and May 2012 MEASUREMENTS AND FINDINGS: we performed linear regression analyses to test the associations of pregnancy related, non-pregnancy related life events, childhood adversities and the personality traits neuroticism and extraversion with the change in symptoms of anxiety (State Trait Anxiety Inventory) and depression (Edinburgh Postnatal Depression Scale) from week 12 to week 36. Life events during pregnancy were associated with increasing antenatal symptoms of anxiety and depression. Effect sizes associated with the highest numbers of events observed ranged from 0.59 to 1.31. Pregnancy related events were specifically associated with increasing symptoms of anxiety (p=0.009), whereas non-pregnancy related events were merely associated with an increase in symptoms of depression (pKEY CONCLUSIONS: the most important finding is that pregnancy related life events during pregnancy increase levels of antenatal anxiety, whereas depression levels increase when women experience life events that are unrelated to pregnancy. Furthermore, non-pregnancy related events show stronger associations with increases in symptoms of anxiety or depression compared to pregnancy related events.IMPLICATIONS FOR PRACTICE: our findings may help midwives to tailor psychosocial care to the specific risks of the pregnant woman which may eventually have a positive impact on the health of mother and child.
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- 2014
19. Perceptions of hospitalization-related trauma and treatment participation among individuals with psychotic disorders
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Paksarian, D., Mojtabai, R., Kotov, R., Cullen, B., Nugent, K.L., and Bromet, E.J.
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Adult ,Employment ,Male ,Time Factors ,Coercion ,Article ,Hospitalization ,Sex Factors ,England ,Psychotic Disorders ,Commitment of Mentally Ill ,Humans ,Patient Compliance ,Female ,Prospective Studies ,Stress, Psychological - Abstract
OBJECTIVE; This study assessed the association of perceptions of traumatic experiences during psychiatric hospitalizations and treatment participation.Participants (N=395) in the Suffolk County Mental Health Project, who had been admitted for the first time for a psychotic disorder ten years earlier, were interviewed. The authors examined associations of perceived trauma and distressing or coercive experiences during hospitalizations in the past ten years with patient characteristics and treatment participation.Sixty-nine percent of participants reported perceived trauma. Perceived trauma was more common among females versus males and homemakers versus full-time workers. It was not associated with treatment seeking or time in treatment. However, reporting forced medication was associated with reduced time in treatment, especially for persons with schizophrenia spectrum disorders.Although perceptions of trauma during psychiatric hospitalization were common, they may be unrelated to treatment participation. However, there was modest evidence of a link between coercive experiences and reduced treatment time.
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- 2014
20. Study of W boson production in PbPb and pp collisions at √sNN=2.76 TeV
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Chatrchyan, S., Khachatryan, V., Sirunyan, A. M., Tumasyan, A., Adam, W., Bergauer, T., Dragicevic, M., Erö, J., Fabjan, C., Friedl, M., Frühwirth, R., Ghete, V. M., Hammer, J., Hörmann, N., Hrubec, J., Jeitler, M., Kiesenhofer, W., Knünz, V., Krammer, M., Liko, D., Mikulec, I., Pernicka, M., Rahbaran, B., Rohringer, C., Rohringer, H., Schöfbeck, R., Strauss, J., Taurok, A., Wagner, P., Waltenberger, W., Walzel, G., Widl, E., Wulz, C. E., Mossolov, V., Shumeiko, N., Suarez, Gonzalez, Bansal, J., Cornelis, S., Wolf, De, E. A., Janssen, Luyckx, X., Maes, S., Mucibello, T., Ochesanu, L., Roland, S., Rougny, B., Selvaggi, R., Staykova, M., Van, Haevermaet, Van, Mechelen, Van, Remortel, Van, Spilbeeck, Blekman, A., Blyweert, F., D'Hondt, S., Gonzalez, Suarez, Kalogeropoulos, R., Maes, A., Olbrechts, M., Van, Doninck, Van, Mulders, Van, Onsem, G. P., Villella, Charaf, I., Clerbaux, O., Lentdecker, De, Dero, G., Gay, V., A. P. R., Hreus, Léonard, T., Marage, A., P. E., Reis, Thomas, T., Vander, Velde, Vanlaer, C., Wang, P., Adler, J., Beernaert, V., Cimmino, K., Costantini, A., Garcia, S., Grunewald, G., Klein, M., Lellouch, B., Marinov, J., Mccartin, A., Ocampo, Rios, A. A., Ryckbosch, Strobbe, D., Thyssen, N., Tytgat, F., Vanelderen, M., Verwilligen, L., Walsh, P., Yazgan, S., Zaganidis, E., Basegmez, N., Bruno, S., Castello, G., Caudron, R., Ceard, A., Delaere, L., Pree, Du, Favart, T., Forthomme, D., Giammanco, L., Hollar, A., Lemaitre, J., Liao, V., Militaru, J., Nuttens, O., Pagano, C., Perrini, D., Pin, L., Piotrzkowski, A., Schul, K., Vizan, Garcia, J. M., Beliy, Caebergs, N., Daubie, T., Hammad, E., G. H., Alves, G. A., Correa Martins Junior, De Jesus Damiao, Martins, D., Pol, T., M. E., Souza, M. H. G., Aldá, Júnior, W. L., Carvalho, Custódio, W., Costa, Da, E. M., De Oliveira Martins, Fonseca De Souza, Matos, Figueiredo, Mundim, D., Nogima, L., Oguri, H., Prado Da Silva, W. L., Santoro, Soares, Jorge, Sznajder, L., Bernardes, A., C. A., Dias, F. A., Fernandez Perez Tomei, T. R., Gregores, E. M., Lagana, Marinho, C., Mercadante, F., P. G., Novaes, S. F., Padula, S. S., Genchev, Iaydjiev, V., Piperov, P., Rodozov, S., Stoykova, M., Sultanov, S., Tcholakov, G., Trayanov, V., Vutova, R., Dimitrov, M., Hadjiiska, A., Kozhuharov, R., Litov, V., Pavlov, L., Petkov, B., Bian, P., J. G., Chen, G. M., Chen, H. S., Jiang, C. H., Liang, Liang, D., Meng, S., Tao, X., Wang, J., Wang, X., Xiao, Z., Xu, H., Zang, M., Zhang, J., Asawatangtrakuldee, Z., Ban, C., Guo, Y., Guo, S., Li, Y., Liu, W., Mao, S., Qian, Y., S. J., Teng, Wang, H., Zhu, S., Zou, B., Avila, W., Gomez, C., J. P., Gomez, Moreno, Osorio, Oliveros, A. F., Sanabria, J. C., Godinovic, Lelas, N., Plestina, D., Polic, R., Puljak, D., Antunovic, I., Kovac, Z., Brigljevic, M., Duric, V., Kadija, S., Luetic, K., Morovic, J., Attikis, S., Galanti, A., Mavromanolakis, M., Mousa, G., Nicolaou, J., Ptochos, C., Razis, F., P. A., Finger, Finger, M., Assran, M., Elgammal, Y., Ellithi, Kamel, Khalil, A., Mahmoud, S., M. A., Radi, Kadastik, A., Müntel, M., Raidal, M., Rebane, M., Tiko, L., Azzolini, A., Eerola, V., Fedi, P., Voutilainen, G., Härkönen, M., Heikkinen, J., Karimäki, A., Kinnunen, V., Kortelainen, R., M. J., Lampén, Lassila, Perini, Lehti, K., Lindén, S., Luukka, T., Mäenpää, P., Peltola, T., Tuominen, T., Tuominiemi, E., Tuovinen, J., Ungaro, E., Wendland, D., Banzuzi, L., Korpela, K., Tuuva, A., Besancon, T., Choudhury, M., Dejardin, S., Denegri, M., Fabbro, D., Faure, B., J. L., Ferri, Ganjour, F., Givernaud, S., Gras, A., Hamel de Monchenault, Jarry, G., Locci, P., Malcles, E., Millischer, J., Nayak, L., Rander, A., Rosowsky, J., Shreyber, A., Titov, I., Baffioni, M., Beaudette, S., Benhabib, F., Bianchini, L., Bluj, L., Broutin, M., Busson, C., Charlot, P., Daci, C., Dahms, N., Dobrzynski, T., Granier de Cassagnac, Haguenauer, R., Miné, M., Mironov, P., Nguyen, C., Ochando, M., Paganini, C., Sabes, P., Salerno, D., Sirois, R., Veelken, Y., Zabi, C., Agram, A., J. L., Andrea, Bloch, J., Bodin, D., Brom, D., J. M., Cardaci, Chabert, M., E. C., Collard, Conte, C., Drouhin, E., Ferro, F., Fontaine, C., J. C., Gelé, Goerlach, D., Juillot, U., Karim, P., Bihan, Le, A. C., Van, Hove, Fassi, P., Mercier, F., Beauceron, D., Beaupere, S., Bondu, N., Boudoul, O., Brun, G., Chasserat, H., Chierici, J., Contardo, R., Depasse, D., Mamouni, El, Fay, H., Gascon, J., Gouzevitch, S., Ille, M., Kurca, B., Lethuillier, T., Mirabito, M., Perries, L., Sordini, S., Tosi, V., Tschudi, S., Verdier, Y., Viret, P., Tsamalaidze, S., Anagnostou, Z., Beranek, G., Edelhoff, S., Feld, M., Heracleous, L., Hindrichs, N., Jussen, O., Klein, R., Merz, K., Ostapchuk, J., Perieanu, A., Raupach, A., Sammet, F., Schael, J., Sprenger, S., Weber, D., Wittmer, H., Zhukov, B., Ata, V., Caudron, M., Dietz, Laursonn, Duchardt, E., Erdmann, D., Fischer, M., Güth, R., Hebbeker, A., Heidemann, T., Hoepfner, C., Klingebiel, K., Kreuzer, D., Lingemann, P., Magass, J., Merschmeyer, C., Meyer, M., Olschewski, A., Papacz, M., Pieta, P., Reithler, H., Schmitz, H., S. A., Sonnenschein, Steggemann, L., Teyssier, J., Bontenackels, M., Cherepanov, M., Davids, V., Flügge, M., Geenen, G., Geisler, H., Haj, Ahmad, Hoehle, W., Kargoll, F., Kress, B., Kuessel, T., Linn, Y., Nowack, A., Perchalla, A., Pooth, L., Rennefeld, O., Sauerland, J., Stahl, P., Aldaya, Martin, Behr, M., Behrenhoff, J., Behrens, W., Bergholz, U., Bethani, M., Borras, A., Burgmeier, K., Cakir, A., Calligaris, A., Campbell, L., Castro, A., Costanza, E., Dammann, F., Eckerlin, D., Eckstein, G., Fischer, D., Flucke, D., Geiser, G., Glushkov, A., Gunnellini, I., Habib, P., Hauk, S., Hellwig, J., Jung, G., Kasemann, H., Katsas, M., Kleinwort, P., Kluge, C., Knutsson, H., Krämer, A., Krücker, M., Kuznetsova, D., Lange, E., Lohmann, W., Lutz, W., Mankel, B., Marfin, R., Marienfeld, I., Melzer, Pellmann, I. A., Meyer, A. B., Mnich, Mussgiller, J., Naumann, Emme, Olzem, S., Perrey, J., Petrukhin, H., Pitzl, A., Raspereza, D., Ribeiro, Cipriano, P. M., Riedl, Rosin, C., Salfeld, Nebgen, Schmidt, J., Schoerner, Sadenius, Sen, T., Spiridonov, N., Stein, A., Walsh, M., Wissing, R., Autermann, C., Blobel, C., Bobrovskyi, V., Draeger, S., Enderle, J., Erfle, H., Gebbert, J., Görner, U., Hermanns, M., Höing, T., R. S., Kaschube, Kaussen, K., Kirschenmann, G., Klanner, H., Lange, R., Mura, J., Nowak, B., Peiffer, F., Pietsch, T., Rathjens, N., Sander, D., Schettler, C., Schleper, H., Schlieckau, P., Schmidt, E., Schröder, A., Schum, M., Seidel, T., Stadie, M., Steinbrück, H., Thomsen, G., Barth, J., Berger, C., Böser, J., Chwalek, C., Boer, De, Descroix, W., Dierlamm, A., Feindt, A., Guthoff, M., Hackstein, M., Hartmann, C., Hauth, F., Heinrich, T., Held, M., Hoffmann, H., K. H., Honc, Katkov, S., Komaragiri, I., J. R., Martschei, Mueller, D., Müller, S., Niegel, T., Nürnberg, M., Oberst, A., Oehler, O., Ott, A., Quast, J., Rabbertz, G., Ratnikov, K., Ratnikova, F., Röcker, N., Scheurer, S., Schilling, A., F. P., Schott, Simonis, G., H. J., Stober, F. M., Troendle, Ulrich, D., Wagner, Kuhr, Wayand, J., Weiler, S., Zeise, T., Daskalakis, M., Geralis, G., Kesisoglou, T., Kyriakis, S., Loukas, A., Manolakos, D., Markou, I., Markou, A., Mavrommatis, C., Ntomari, C., Gouskos, E., Mertzimekis, L., T. J., Panagiotou, Saoulidou, A., Evangelou, N., Foudas, I., Kokkas, C., Manthos, P., Papadopoulos, N., Patras, I., Bencze, V., Hajdu, G., Hidas, C., Horvath, P., Krajczar, D., Radics, K., Sikler, B., Veszpremi, F., Vesztergombi, V., Beni, G., Czellar, N., Molnar, S., Palinkas, J., Szillasi, J., Karancsi, Z., Raics, J., Trocsanyi, P., Z. L., Ujvari, Beri, B., S. B., Bhatnagar, Dhingra, V., Gupta, N., Jindal, R., Kaur, M., Mehta, M., M. Z., Nishu, Saini, N., L. K., Sharma, Singh, A., Ahuja, J., Bhardwaj, S., Choudhary, A., B. C., Kumar, Kumar, A., Malhotra, A., Naimuddin, S., Ranjan, M., Sharma, K., Shivpuri, V., R. K., Banerjee, Bhattacharya, S., Dutta, S., Gomber, S., Jain, B., Jain, S., Khurana, S., Sarkar, R., Sharan, S., Abdulsalam, M., Choudhury, A., R. K., Dutta, Kailas, D., Kumar, S., Mehta, V., Mohanty, P., A. K., Pant, L. M., Shukla, Aziz, P., Ganguly, T., Guchait, S., Maity, M., Majumder, M., Mazumdar, G., Mohanty, K., G. B., Parida, Sudhakar, B., Wickramage, K., Banerjee, N., Dugad, S., Arfaei, S., Bakhshiansohi, H., Etesami, H., S. M., Fahim, Hashemi, A., Hesari, M., Jafari, H., Khakzad, A., Mohammadi, M., Mohammadi, Najafabadi, Paktinat, Mehdiabadi, Safarzadeh, S., Zeinali, B., Abbrescia, M., Barbone, M., Calabria, L., Chhibra, C., S. S., Colaleo, Creanzaa, A., Filippis, De, Palmaa, De, Fiore, M., Iaselli, L., Lusito, G., Maggi, L., Maggi, G., Marangelli, M., Mya, B., Nuzzo, S., Pacifico, S., Pompili, N., Pugliese, A., Selvaggi, G., Silvestris, G., Singh, L., Venditti, G., Zito, R., Abbiendi, G., Benvenuti, G., A. C., Bonacorsi, Braibant, Giacomelli, Brigliadori, S., Capiluppi, L., Castro, P., Cavallo, A., F. R., Cuffiani, Dallavalle, M., G. M., Fabbri, Fanfani, F., Fasanella, A., Giacomelli, D., Grandi, P., Guiducci, C., Marcellini, L., Masetti, S., Meneghelli, G., Montanari, M., Avarria, A., F. L., Odorici, Perrottaa, F., Primavera, A., Rossi, F., A. M., Rovelli, Siroli, T., Travaglini, G., Albergo, R., Cappello, S., Chiorboli, G., Costa, M., Potenza, S., Tricomi, R., Tuve, A., Barbagli, C., Ciulli, G., Civinini, V., D'Alessandro, C., Focardi, R., Frosali, E., Gallo, S., Gonzi, E., Meschini, S., Paoletti, M., Sguazzoni, S., Tropiano, G., Benussi, A., Bianco, L., Colafranceschi, S., Fabbri, S., Piccolo, F., Fabbricatore, D., Musenich, P., Benaglia, R., Guio, De, Matteo, Di, Fiorendi, L., Gennai, S., Ghezzi, S., Malvezzi, A., Manzoni, S., R. A., Martelli, Massironi, A., Menascea, A., Moroni, D., Paganoni, L., Pedrini, M., Ragazzi, D., Redaelli, S., Salaa, N., Tabarelli de Fatis, Buontempo, T., Carrillo, Montoya, C. A., Cavallo, Cosa, De, Dogangun, A., Fabozzi, O., Iorio, F., A. O. M., Listaa, Meola, L., Merolaa, S., Paolucci, M., Azzi, P., Bacchetta, P., Bisello, N., Branca, D., Carlin, A., Checchia, R., Dorigo, P., Dosselli, T., Gasparini, U., Gasparini, F., Gozzelino, U., Kanishchev, A., Lacaprara, K., Lazzizzera, S., Margoni, I., Meneguzzo, M., A. T., Pazzini, Perrozzi, J., Pozzobon, L., Ronchese, N., Simonetto, P., Torassa, F., Tosi, E., Vanini, M., Zotto, S., Zucchettaa, P., Zumerle, A., Gabusi, G., Ratti, M., S. P., Riccardi, Torre, C., Vitulo, P., Biasini, P., Bilei, M., G. M., Fanò, Lariccia, L., Lucaroni, P., Mantovani, A., Menichelli, G., Nappi, M., Romeo, A., Saha, F., Santocchia, A., Taroni, A., Azzurri, S., Bagliesi, P., Boccali, G., Broccolo, T., Castaldi, G., D'Agnolo, R., R. T., Dell'Orso, Fiori, R., Foà, F., Giassi, L., Kraan, A., Ligabue, A., Lomtadze, F., Martini, T., Messineo, ALBERTO MARIA, Palla, F., Rizzi, Andrea, Serban, A. T., Spagnolo, P., Squillacioti, P., Tenchini, R., Tonelli, GUIDO EMILIO, Venturi, A., Verdini, P. G., Barone, L., Cavallari, F., Del, Re, Diemoz, D., Grassi, M., Longo, M., Meridiani, E., Micheli, P., Nourbakhsh, F., Organtini, S., Paramatti, G., Rahatlou, R., Sigamani, S., Soffi, M., Amapane, L., Arcidiacono, N., Argiro, R., Arneodo, S., Biino, M., Botta, C., Cartiglia, C., Costa, N., Demaria, M., Graziano, N., Mariotti, A., Maselli, C., Migliore, S., Monaco, E., Musich, V., Obertino, M., M. M., Pastrone, Pelliccioni, N., Potenza, M., Romero, A., Ruspa, A., Sacchi, M., Sola, R., Solano, V., Staiano, A., Vilela, Pereira, Belforte, A., Cossutti, S., Della, Ricca, Gobbo, G., Marone, B., Montanino, M., Penzoa, D., Schizzi, A., Heo, A., S. G., Kim, T. Y., Nam, S. K., Chang, Chung, S., Kim, J., D. H., Kim, G. N., Kong, D. J., Park, Ro, H., S. R., Son, D. C., Son, Kim, T., J. Y., Kim, Z. J., Song, Jo, S., H. Y., Choi, Gyun, S., Hong, D., Jo, B., Kim, M., Kim, H., T. J., Lee, K. S., Moon, D. H., Park, S. K., Choi, Kang, M., Kim, S., J. H., Park, Park, C., I. C., Park, Ryu, S., Cho, G., Choi, Y., Y. K., Goh, M. S., Kwon, Lee, E., Lee, B., Lee, J., Seo, S., Yu, H., Bilinskas, I., M. J., Grigelionis, Janulis, I., Juodagalvis, M., Castilla, Valdez, De La Cruz Burelo, Heredia de La Cruz, Lopez, Fernandez, Magaña, Villalba, Martínez, Ortega, Sánchez, Hernández, Villasenor, Cendejas, L. M., Carrillo, Moreno, Vazquez, Valencia, Salazar, Ibarguen, H. A., Casimiro, Linares, Morelos, Pineda, Reyes, Santos, M. A., Krofcheck, Bell, D., A. J., Butler, P. H., Doesburg, Reucroft, R., Silverwood, S., Ahmad, H., Asghar, M., M. I., Hoorani, H. R., Khalid, Khan, S., W. A., Khurshid, Qazi, T., Shah, S., M. A., Shoaib, Brona, M., Bunkowski, G., Cwiok, K., Dominik, M., Doroba, W., Kalinowski, K., Konecki, A., Krolikowski, M., Bialkowska, J., Boimska, H., Frueboes, B., Gokieli, T., Górski, R., Kazana, M., Nawrocki, M., Romanowska, Rybinska, Szleper, K., Wrochna, M., Zalewski, G., Almeida, P., Bargassa, N., David, P., Faccioli, A., Fernandes, P., Ferreira, Parracho, P. G., Gallinaro, Seixas, M., Varela, J., Vischia, J., Afanasiev, P., Belotelov, S., Bunin, I., Gavrilenko, P., Golutvin, M., Kamenev, I., Karjavin, A., Kozlov, V., Lanev, G., Malakhov, A., Moisenz, A., Palichik, P., Perelygin, V., Shmatov, V., Smirnov, S., Volodko, V., Zarubin, A., Evstyukhin, A., Golovtsov, S., Ivanov, V., Kim, Y., Levchenko, V., Murzin, P., Oreshkin, V., Smirnov, V., Sulimov, I., Uvarov, V., Vavilov, L., Vorobyev, S., Vorobyev, A., Andreev, A., Dermenev, Y., Gninenko, A., Golubev, S., Kirsanov, N., Krasnikov, M., Matveev, N., Pashenkov, V., Tlisov, A., Toropin, D., Epshteyn, A., Erofeeva, V., Gavrilov, M., Kossov, V., Lychkovskaya, M., Popov, N., Safronov, V., Semenov, G., Stolin, S., Vlasov, V., Zhokin, E., Belyaev, A., Boos, A., Ershov, E., Gribushin, A., Klyukhin, A., Kodolova, V., Korotkikh, O., Lokhtin, V., Markina, I., Obraztsov, A., Perfilov, S., Petrushanko, M., Popov, S., Sarycheva, A., Savrin, L., Snigirev, V., Vardanyan, A., Andreev, I., Azarkin, V., Dremin, M., Kirakosyan, I., Leonidov, M., Mesyats, A., Rusakov, G., S. V., Vinogradov, Azhgirey, A., Bayshev, I., Bitioukov, I., Grishin, S., Kachanov, V., Konstantinov, V., Korablev, D., Krychkine, A., Petrov, V., Ryutin, V., Sobol, R., Tourtchanovitch, A., Troshin, L., Tyurin, S., Uzunian, N., Volkov, A., Adzic, A., Djordjevic, P., Ekmedzic, M., Krpic, M., Milosevic, D., Aguilar, Benitez, Alcaraz, Maestre, Arce, J., Battilana, P., Calvo, C., Cerrada, E., Chamizo, Llatas, Colino, M., De La Cruz, Delgado, Peris, Diez, Pardos, Domínguez, Vázquez, Fernandez, Bedoya, Fernández, Ramos, J. P., Ferrando, Flix, A., Fouz, J., M. C., Garcia, Abia, Gonzalez, Lopez, Goy, Lopez, Hernandez, S., J. M., Josa, M. I., Merino, Puerta, Pelayo, Quintario, Olmeda, Redondo, A., Romero, I., Santaolalla, L., Soares, J., M. S., Willmott, Albajar, C., Codispoti, C., Trocóniz, De, J. F., Cuevas, Fernandez, Menendez, Folgueras, J., Gonzalez, Caballero, Lloret, Iglesias, Piedra, Gomez, Brochero, Cifuentes, J. A., Cabrillo, I. J., Calderon, Chuang, A., S. H., Duarte, Campderros, Felcini, J., Fernandez, M., Gomez, M., Gonzalez, Sanchez, Jorda, J., Lobelle, Pardo, Lopez, Virto, Marco, A., Marco, J., Martinez, Rivero, Matorras, C., Munoz, Sanchez, F. J., Rodrigo, Rodríguez, Marrero, A. Y., Ruiz, Jimeno, Scodellaro, A., Sobron, Sanudo, Vila, M., Vilar, Cortabitarte, Abbaneo, R., Auffray, D., Auzinger, E., Baillon, G., Ball, P., A. H., Barney, Bernet, D., Bianchi, C., Bloch, G., Bocci, P., Bonato, A., Breuker, A., Camporesi, H., Cerminara, T., Christiansen, G., Coarasa, Perez, J. A., D'Enterria, Dabrowski, D., Roeck, De, Guida, Di, Dobson, S., Dupont, Sagorin, Elliott, Peisert, Frisch, A., Funk, B., Georgiou, W., Giffels, G., Gigi, M., Gill, D., Giordano, K., Giunta, D., Glege, M., Gomez Reino Garrido, Govoni, R., Gowdy, P., Guida, S., Hansen, R., Harris, M., Hartl, P., Harvey, C., Hegner, J., Hinzmann, B., Innocente, A., Janot, V., Kaadze, P., Karavakis, K., Kousouris, E., Lecoq, K., Lee, P., Y. J., Lenzi, Lourenço, P., Mäki, C., Malberti, T., Malgeri, M., Mannelli, L., Masetti, M., Meijers, L., Mersi, F., Meschi, S., Moser, E., Mozer, R., M. U., Mulders, Musella, M., Nesvold, P., Orimoto, E., Orsini, T., Palencia, Cortezon, Perez, E., Petrilli, E., Pfeiffer, A., Pierini, A., Pimiä, M., Piparo, M., Polese, D., Quertenmont, G., Racz, L., Reece, A., Rodrigues, Antunes, Rolandi, J., Rommerskirchen, G., Rovelli, T., Rovere, C., Sakulin, M., Santanastasio, H., Schäfer, F., Schwick, C., Segoni, C., Sekmen, I., Sharma, S., Siegrist, A., Silva, P., Simon, P., Sphicas, M., Spiga, P., Spiropulu, D., Stoye, M., Tsirou, M., Veres, A., G. I., Vlimant, J. R., Wöhri, H. K., Worm, S. D., Zeuner, W. D., Bertl, Deiters, W., Erdmann, K., Gabathuler, W., Horisberger, K., Ingram, R., Kaestli, Q., H. C., König, Kotlinski, S., Langenegger, D., Meier, U., Renker, F., Rohe, D., Sibille, T., Bäni, J., Bortignon, L., Buchmann, P., M. A., Casal, Chanon, B., Deisher, N., Dissertori, A., Dittmar, G., Dünser, M., Eugster, M., Freudenreich, J., Grab, K., Hits, C., Lecomte, D., Lustermann, P., Marini, W., Martinez Ruiz del Arbol, Mohr, P., Moortgat, N., Nägeli, F., Nef, C., Nessi, Tedaldi, Pandolfi, F., Pape, F., Pauss, L., Peruzzi, F., Ronga, M., F. J., Rossini, Sala, M., Sanchez, L., A. K., Starodumov, Stieger, A., Takahashi, B., Tauscher, M., Thea, L., Theofilatos, A., Treille, K., Urscheler, D., Wallny, C., Weber, R., H. A., Wehrli, Aguilo, L., Amsler, E., Chiochia, C., Visscher, De, Favaro, S., Ivova, Rikova, Millan, Mejias, Otiougova, B., Robmann, P., Snoek, P., Tupputi, H., Verzetti, S., Chang, M., Y. H., Chen, K. H., Kuo, C. M., Li, S. W., Lin, Z. K., Lu, Y. J., Mekterovic, Singh, D., A. P., Volpe, Yu, R., S. S., Bartalini, Chang, P., Y. H., Chang, Y. W., Chao, Chen, Y., K. F., Dietz, Grundler, C., Hou, U., W. S., Hsiung, Kao, Y., K. Y., Lei, Y. J., Lu, R. S., Majumder, Petrakou, D., Shi, E., Shiu, X., J. G., Tzeng, Y. M., Wan, Adiguzel, M., Bakirci, A., M. N., Cerci, Dozen, S., Dumanoglu, C., Eskut, I., Girgis, E., Gokbulut, S., Gurpinar, G., Hos, E., Kangal, I., E. E., Karapinar, Kayis, Topaksu, Onengut, A., Ozdemir, G., Ozturk, K., Polatoz, S., Sogut, A., Sunar, Cerci, Tali, D., Topakli, B., Vergili, H., L. N., Vergili, Akin, M., I. V., Aliev, Bilin, T., Bilmis, B., Deniz, S., Gamsizkan, M., Guler, H., A. M., Ocalan, Ozpineci, K., Serin, A., Sever, M., Surat, R., U. E., Yalvac, Yildirim, M., Zeyrek, E., Gülmez, M., Isildak, E., Kaya, B., Kaya, M., Ozkorucuklu, O., Sonmez, S., Cankocak, N., Levchuk, K., Bostock, L., Brooke, F., J. J., Clement, Cussans, E., Flacher, D., Frazier, H., Goldstein, R., Grimes, J., Heath, M., G. P., Heath, H. F., Kreczko, Metson, L., Newbold, S., D. M., Nirunpong, Poll, K., Senkin, A., Smith, S., V. J., Williams, Basso, T., Belyaev, L., Brew, A., Brown, C., R. M., Cockerill, D. J. A., Coughlan, J. A., Harder, Harper, K., Jackson, S., Kennedy, J., B. W., Olaiya, Petyt, E., Radburn, Smith, B. C., Shepherd, Themistocleous, C. H., Tomalin, I. R., Womersley, W. J., Bainbridge, Ball, R., Beuselinck, G., Buchmuller, R., Colling, O., Cripps, D., Cutajar, N., Dauncey, M., Davies, P., Della, Negra, Ferguson, M., Fulcher, W., Futyan, J., Gilbert, D., Guneratne, Bryer, Hall, A., Hatherell, G., Hays, Z., Iles, J., Jarvis, G., Karapostoli, M., Lyons, G., Magnan, L., A. M., Marrouche, Mathias, J., Nandi, B., Nash, R., Nikitenko, J., Papageorgiou, A., Pela, A., Pesaresi, J., Petridis, M., Pioppi, K., Raymond, M., D. M., Rogerson, Rose, S., Ryan, A., M. J., Seez, Sharp, C., Sparrow, P., Tapper, A., Vazquez, Acosta, Virdee, M., Wakefield, T., Wardle, S., Whyntie, N., Chadwick, T., Cole, M., J. E., Hobson, P. R., Khan, Kyberd, A., Leggat, P., Leslie, D., Martin, D., Reid, W., I. D., Symonds, Teodorescu, P., Turner, L., Hatakeyama, M., Liu, K., Scarborough, H., Henderson, T., Rumerio, C., Avetisyan, P., Bose, A., Fantasia, T., Heister, C., John, A., S. J., Lawson, Lazic, P., Rohlf, D., Sperka, J., Sulak, D., Alimena, L., Bhattacharya, J., Cutts, S., Ferapontov, D., Heintz, A., Jabeen, U., Kukartsev, S., Laird, G., Landsberg, E., Luk, G., Narain, M., Nguyen, M., Segala, D., Sinthuprasith, M., Speer, T., Tsang, T., K. V., Breedon, Breto, R., Calderon De La Barca Sanchez, Chauhan, M., Chertok, S., Conway, M., Conway, J., Cox, R., P. T., Dolen, Erbacher, J., Gardner, R., Houtz, M., Ko, R., Kopecky, W., Lander, A., Mall, R., Miceli, O., Nelson, T., Pellett, R., Rutherford, D., Searle, B., Smith, M., Squires, J., Tripathi, M., Vasquez, Sierra, Andreev, R., Cline, V., Cousins, D., Duris, R., Erhan, J., Everaerts, S., Farrell, P., Hauser, C., Ignatenko, J., Jarvis, M., Plager, C., Rakness, C., Schlein, G., Tucker, P., Valuev, J., Weber, V., Babb, M., Clare, J., Dinardo, R., M. E., Ellison, Gary, J., J. W., Giordano, Hanson, F., Jeng, G., G. Y., Liu, Long, H., O. R., Luthra, Nguyen, A., Paramesvaran, H., Sturdy, S., Sumowidagdo, J., Wilken, S., Wimpenny, R., Andrews, S., Branson, W., J. G., Cerati, G. B., Cittolin, Evans, S., Golf, D., Holzner, F., Kelley, A., Lebourgeois, R., Letts, M., Macneill, J., Mangano, I., Padhi, B., Palmer, S., Petrucciani, C., Pieri, G., Sani, M., Sharma, M., Simon, V., Sudano, S., Tadel, E., Tu, M., Vartak, Y., Wasserbaech, A., Würthwein, S., Yagil, F., Yoo, A., Barge, J., Bellan, D., Campagnari, R., D'Alfonso, C., Danielson, M., Flowers, T., Geffert, K., Incandela, P., Justus, J., Kalavase, C., Koay, P., S. A., Kovalskyi, Krutelyov, D., Lowette, V., Mccoll, S., Pavlunin, N., Rebassoo, V., Ribnik, F., Richman, J., Rossin, J., Stuart, R., To, D., West, W., Apresyan, C., Bornheim, A., Chen, A., Marco, Di, Duarte, E., Gataullin, J., Ma, M., Mott, Y., Newman, A., H. B., Rogan, Timciuc, C., Traczyk, V., Veverka, P., Wilkinson, J., Yang, R., Zhu, Y., R. Y., Akgun, Carroll, B., Ferguson, R., Iiyama, T., Jang, Y., D. W., Liu, Y. F., Paulini, Vogel, M., Vorobiev, H., Cumalat, I., J. P., Drell, B. R., Edelmaier, C. J., Ford, W. T., Gaz, Heyburn, A., Luiggi, Lopez, Smith, E., J. G., Stenson, Ulmer, K., K. A., Wagner, S. R., Alexander, Chatterjee, J., Eggert, A., Gibbons, N., L. K., Heltsley, Khukhunaishvili, B., Kreis, A., Mirman, B., Nicolas, Kaufman, Patterson, G., J. R., Ryd, Salvati, A., Sun, E., Teo, W., W. D., Thom, Thompson, J., Vaughan, J., Weng, J., Winstrom, Y., Wittich, L., Winn, P., Abdullin, D., Albrow, S., Anderson, M., Bauerdick, J., L. A. T., Beretvas, Berryhill, A., Bhat, J., P. C., Bloch, Burkett, I., Butler, K., J. N., Chetluru, Cheung, V., H. W. K., Chlebana, Elvira, F., V. D., Fisk, Freeman, I., Gao, J., Green, Y., Gutsche, D., Hahn, O., Hanlon, A., Harris, J., R. M., Hirschauer, Hooberman, J., Jindariani, B., Johnson, S., Joshi, M., Kilminster, U., Klima, B., Kunori, B., Kwan, S., Leonidopoulos, S., Lincoln, C., Lipton, D., Lueking, R., Lykken, L., Maeshima, J., Marraffino, K., J. M., Maruyama, Mason, S., Mcbride, D., Mishra, P., Mrenna, K., Musienko, S., Newman, Holmes, O'Dell, C., Prokofyev, V., Sexton, Kennedy, Sharma, E., Spalding, S., W. J., Spiegel, Tan, L., Taylor, P., Tkaczyk, L., Tran, S., N. V., Uplegger, Vaandering, L., E. W., Vidal, Whitmore, R., Wu, J., Yang, W., Yumiceva, F., Yun, F., J. C., Acosta, Avery, D., Bourilkov, P., Chen, D., Das, M., Gruttola, De, Giovanni, Di, G. P., Dobur, Drozdetskiy, D., Field, A., R. D., Fisher, Fu, M., Furic, Y., I. K., Gartner, Hugon, J., Konigsberg, B., Korytov, J., Kropivnitskaya, A., Kypreos, A., Low, T., J. F., Matchev, Milenovic, K., Mitselmakher, P., Muniz, G., Remington, L., Rinkevicius, R., Sellers, A., Skhirtladze, P., Snowball, N., Yelton, M., Zakaria, J., Gaultney, M., Lebolo, V., L. M., Linn, Markowitz, S., Martinez, P., Rodriguez, G., J. L., Adams, J. R., Adams, Askew, T., Bochenek, A., Chen, J., Diamond, J., Gleyzer, B., S. V., Haas, Hagopian, J., Hagopian, S., Jenkins, V., Johnson, M., K. F., Prosper, Veeraraghavan, H., Weinberg, V., Baarmand, M., M. M., Dorney, Hohlmann, B., Kalakhety, M., Vodopiyanov, H., Adams, I., M. R., Anghel, I. M., Apanasevich, Bai, L., Bazterra, Y., V. E., Betts, R. R., Bucinskaite, Callner, I., Cavanaugh, J., Dragoiu, R., Evdokimov, C., Gauthier, O., Gerber, L., C. E., Hamdan, Hofman, S., D. J., Khalatyan, Lacroix, S., Malek, F., O'Brien, M., Silkworth, C., Strom, C., Varelas, D., Akgun, N., Albayrak, U., E. A., Bilki, Clarida, B., Duru, W., Griffiths, F., Merlo, S., J. P., Mermerkaya, Mestvirishvili, H., Moeller, A., Nachtman, A., Newsom, J., C. R., Norbeck, Onel, E., Ozok, Y., Sen, F., Tiras, S., Wetzel, E., Yetkin, J., Yi, T., Barnett, K., B. A., Blumenfeld, Bolognesi, B., Fehling, S., Giurgiu, D., Gritsan, G., A. V., Guo, Z. J., Hu, Maksimovic, G., Rappoccio, P., Swartz, S., Whitbeck, M., Baringer, A., Bean, P., Benelli, A., Grachov, G., Kenny, Iii, R. P., Murray, Noonan, M., Sanders, D., Stringer, S., Tinti, R., Wood, G., J. S., Zhukova, Barfuss, V., A. F., Bolton, Chakaberia, T., Ivanov, I., Makouski, S., Maravin, M., Shrestha, Y., Svintradze, S., Gronberg, I., Lange, J., Wright, D., Baden, D., Boutemeur, A., Calvert, M., Eno, B., S. C., Gomez, J. A., Hadley, N. J., Kellogg, R. G., Kirn, Kolberg, M., Lu, T., Marionneau, Y., Mignerey, M., A. C., Pedro, Peterman, K., Skuja, A., Temple, A., Tonjes, J., M. B., Tonwar, S. C., Twedt, Bauer, E., Bendavid, G., Busza, J., Butz, W., Cali, E., I. A., Chan, Dutta, M., Gomez, Ceballos, Goncharov, G., Hahn, M., K. A., Kim, Klute, Y., Li, M., Luckey, W., P. D., Ma, Nahn, T., Paus, S., Ralph, C., Roland, D., Roland, C., Rudolph, G., Stephans, M., G. S. F., Stöckli, Sumorok, F., Sung, K., Velicanu, K., Wenger, D., E. A., Wolf, Wyslouch, R., Xie, B., Yang, S., Yilmaz, M., Yoon, Y., A. S., Zanetti, Cooper, M., S. I., Dahmes, Benedetti, De, Franzoni, A., Gude, G., Kao, A., S. C., Klapoetke, Kubota, K., Mans, Y., Pastika, J., Rusack, N., Sasseville, R., Singovsky, M., Tambe, A., Turkewitz, N., Cremaldi, J., L. M., Kroeger, Perera, R., Rahmat, L., Sanders, R., D. A., Avdeeva, Bloom, E., Bose, K., Butt, S., Claes, J., D. R., Dominguez, Eads, A., Jindal, M., Keller, P., Kravchenko, J., Lazo, Flores, Malbouisson, J., Malik, H., Snow, S., G. R., Baur, Godshalk, U., Iashvili, A., Jain, I., Kharchilava, S., Shipkowski, A., S. P., Smith, Alverson, K., Barberis, G., Baumgartel, E., Chasco, D., Haley, M., Nash, J., Trocino, D., Wood, D., Zhang, D., Anastassov, J., Kubik, A., Mucia, A., Odell, N., Ofierzynski, N., R. A., Pollack, Pozdnyakov, B., Schmitt, A., Stoynev, M., Velasco, S., Won, M., Antonelli, S., Berry, L., Brinkerhoff, D., Hildreth, A., Jessop, M., Karmgard, C., D. J., Kolb, Lannon, J., Luo, K., Lynch, W., Marinelli, S., Morse, N., D. M., Pearson, Ruchti, T., Slaunwhite, R., Valls, J., Wayne, N., Wolf, M., Bylsma, M., Durkin, B., L. S., Hart, Hill, A., Hughes, C., Kotov, R., Ling, K., T. Y., Puigh, Rodenburg, D., Vuosalo, M., Williams, C., Winer, G., B. L., Adam, Berry, N., Elmer, E., Gerbaudo, P., Halyo, D., Hebda, V., Hegeman, P., Hunt, J., Lopes, Pegna, Lujan, D., Marlow, P., Medvedeva, D., Mooney, T., Olsen, M., Piroué, J., Quan, P., Raval, X., Saka, A., Stickland, H., Tully, D., Werner, C., J. S., Zuranski, Acosta, A., J. G., Brownson, Huang, E., X. T., Lopez, Mendez, A., Oliveros, H., Ramirez, Vargas, J. E., Zatserklyaniy, Alagoz, A., Barnes, E., V. E., Benedetti, Bolla, D., Bortoletto, G., Mattia, De, Everett, M., Hu, A., Jones, Z., Koybasi, M., Kress, O., Laasanen, M., A. T., Leonardo, Maroussov, N., Merkel, V., Miller, P., D. H., Neumeister, Shipsey, N., Silvers, I., Svyatkovskiy, D., Vidal, Marono, Yoo, M., H. D., Zablocki, Zheng, J., Guragain, Y., Parashar, S., Adair, N., Boulahouache, A., Cuplov, C., Ecklund, V., K. M., Geurts, F. J. M., Padley, B. P., Redjimi, Roberts, R., Zabel, J., Betchart, J., Bodek, B., Chung, A., Y. S., Covarelli, Barbaro, De, Demina, P., Eshaq, R., Garcia, Bellido, Goldenzweig, A., Han, P., Harel, J., Miner, A., D. C., Vishnevskiy, Zielinski, D., Bhatti, M., Ciesielski, A., Demortier, R., Goulianos, L., Lungu, K., Malik, G., Mesropian, S., Arora, C., Barker, S., Chou, A., Contreras, Campana, Duggan, E., Ferencek, D., Gershtein, D., Gray, Y., Halkiadakis, R., Hidas, E., Lath, D., Panwalkar, A., Park, S., Patel, M., Rekovic, R., Richards, V., Robles, A., Rose, J., Salur, K., Schnetzer, S., Seitz, S., Somalwar, C., Stone, S., Thomas, R., Cerizza, S., Hollingsworth, G., Spanier, M., Z. C., York, Eusebi, A., Flanagan, R., Gilmore, W., Kamon, J., Khotilovich, T., Montalvo, V., Osipenkov, R., Pakhotin, I., Perloff, Y., Roe, A., Safonov, J., Sakuma, A., Sengupta, T., Suarez, S., Tatarinov, I., Toback, A., Akchurin, D., Damgov, N., Dudero, J., P. R., Jeong, Kovitanggoon, C., Lee, K., S. W., Libeiro, Roh, T., Volobouev, Y., Appelt, I., Engh, E., Florez, D., Greene, C., Gurrola, S., Johns, A., Johnston, W., Kurt, C., Maguire, P., Melo, C., Sheldon, A., Snook, P., Tuo, B., Velkovska, S., Arenton, J., M. W., Balazs, Boutle, M., Cox, S., Francis, B., Goodell, B., Hirosky, J., Ledovskoy, R., Lin, A., Neu, C., Wood, C., Yohay, J., Gollapinni, R., Harr, S., Karchin, R., P. E., Kottachchi Kankanamge Don, Lamichhane, C., Sakharov, P., Anderson, A., Bachtis, M., Belknap, M., Borrello, D., Carlsmith, L., Cepeda, D., Dasu, M., Gray, S., Grogg, L., K. S., Grothe, Hall, Wilton, Herndon, R., Hervé, M., Klabbers, A., Klukas, P., Lanaro, J., Lazaridis, A., Leonard, C., Loveless, J., Mohapatra, R., Ojalvo, A., Palmonari, I., Pierro, F., G. A., Ross, Savin, I., Smith, A., W. H., Swanson, Guo S, J., Guo, Y, Li, W, Mao, Y, Qian, Sj, Teng, H, Zhang, L, Zhu, B, Zou, W, Cabrera, A, Moreno, Bg, Rios, Aao, Oliveros, Afo, Sanabria, Jc, Godinovic, N, Lelas, D, Lelas, K, Plestina, R, Polic, D, Puljak, I, Antunovic, Z, Dzelalija, M, Brigljevic, V, Duric, S, Kadija, K, Morovic, S, Attikis, A, Galanti, M, Mousa, J, Nicolaou, C, Ptochos, F, Razis, Pa, Rykaczewski, H, Assran, Y, Mahmoud, Ma, Hektor, A, Kadastik, M, Kannike, K, Muentel, M, Raidal, M, Rebane, L, Azzolini, V, Eerola, P, Czellar, S, Harkonen, J, Heikkinen, A, Karimaki, V, Kinnunen, R, Klem, J, Kortelainen, Mj, Lampen, T, Lassila Perini, K, Lehti, S, Linden, T, Luukka, P, Maenpaa, T, Tuominen, E, Tuominiemi, J, Tuovinen, E, Ungaro, D, Wendland, L, Banzuzi, K, Korpela, A, Tuuva, T, Sillou, D, Besancon, M, Choudhury, S, Dejardin, M, Denegri, D, Fabbro, B, Faure, Jl, Ferri, F, Ganjour, S, Gentit, Fx, Givernaud, A, Gras, P, de Monchenault GH, Jarry, P, Locci, E, Malcles, J, Marionneau, M, Millischer, L, Rander, J, Rosowsky, A, Shreyber, I, Titov, M, Verrecchia, P, Baffioni, S, Beaudette, F, Bianchini, L, Bluj, M, Broutin, C, Busson, P, Charlot, C, Dahms, T, Dobrzynski, L, de Cassagnac RG, Haguenauer, M, Mine, P, Mironov, C, Ochando, C, Paganini, P, Sabes, D, Salerno, R, Sirois, Y, Thiebaux, C, Wyslouch, B, Zabi, A, Agram, Jl, Andrea, J, Besson, A, Bloch, D, Bodin, D, Brom, Jm, Cardaci, M, Chabert, Ec, Collard, C, Conte, E, Drouhin, F, Ferro, C, Fontaine, Jc, Gele, D, Goerlach, U, Greder, S, Juillot, P, Karim, M, Le Bihan AC, Mikami, Y, Van Hove, P, Fassi, F, Mercier, D, Baty, C, Beaupere, N, Bedjidian, M, Bondu, O, Boudoul, G, Boumediene, D, Brun, H, Chanon, N, Chierici, R, Contardo, D, Depasse, P, El Mamouni, H, Falkiewicz, A, Fay, J, Gascon, S, Ille, B, Kurca, T, Le Grand, T, Lethuillier, M, Mirabito, L, Perries, S, Sordini, V, Tosi, S, Tschudi, Y, Verdier, P, Xiao, H, Roinishvili, V, Lomidze, D, Anagnostou, G, Edelhoff, M, Feld, L, Heracleous, N, Hindrichs, O, Jussen, R, Klein, K, Merz, J, Mohr, N, Ostapchuk, A, Perieanu, A, Raupach, F, Sammet, J, Schael, S, Sprenger, D, Weber, H, Weber, M, Wittmer, B, Ata, M, Bender, W, Erdmann, M, Frangenheim, J, Hebbeker, T, Hinzmann, A, Hoepfner, K, Hof, C, Klimkovich, T, Klingebiel, D, Kreuzer, P, Lanske, D, Magass, C, Masetti, G, Merschmeyer, M, Meyer, A, Papacz, P, Pieta, H, Reithler, H, Schmitz, Sa, Sonnenschein, L, Steggemann, J, Teyssier, D, Bontenackels, M, Davids, M, Duda, M, Flugge, G, Geenen, H, Giffels, M, Ahmad, Wh, Heydhausen, D, Kress, T, Kuessel, Y, Linn, A, Nowack, A, Perchalla, L, Pooth, O, Rennefeld, J, Sauerland, P, Stahl, A, Thomas, M, Tornier, D, Zoeller, Mh, Martin, Ma, Behrenhoff, W, Behrens, U, Bergholz, M, Borras, K, Cakir, A, Campbell, A, Castro, E, Dammann, D, Eckerlin, G, Eckstein, D, Flossdorf, A, Flucke, G, Geiser, A, Glushkov, I, Hauk, J, Jung, H, Kasemann, M, Katkov, I, Katsas, P, Kleinwort, C, Kluge, H, Knutsson, A, Krucker, D, Kuznetsova, E, Lange, W, Lohmann, W, Mankel, R, Marienfeld, M, Melzer Pellmann IA, Meyer, Ab, Mnich, J, Mussgiller, A, Olzem, J, Parenti, A, Raspereza, A, Raval, A, Schmidt, R, Schoerner Sadenius, T, Sen, N, Stein, M, Tomaszewska, J, Volyanskyy, D, Walsh, R, Wissing, C, Autermann, C, Bobrovskyi, S, Draeger, J, Enderle, H, Gebbert, U, Kaschube, K, Kaussen, G, Klanner, R, Lange, J, Mura, B, Naumann Emme, S, Nowak, F, Pietsch, N, Sander, C, Schettler, H, Schleper, P, Schroder, M, Schum, T, Schwandt, J, Srivastava, Ak, Stadie, H, Steinbruck, G, Thomsen, J, Wolf, R, Barth, C, Bauer, J, Buege, V, Chwalek, T, De Boer, W, Dierlamm, A, Dirkes, G, Feindt, M, and Gruschke, J.
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Heavy-ions ,Nuclear and High Energy Physics ,Heavy Ion collision ,CMS experiment ,ROOT-S=7 TEV ,Physics::Instrumentation and Detectors ,CMS ,Physics ,ATLAS DETECTOR ,W bosons ,HEAVY-ION COLLISIONS ,PRODUCTION CROSS-SECTION ,Physics and Astronomy ,High Energy Physics::Experiment ,LHC ,Nuclear Experiment - Abstract
A measurement is presented of W-boson production in PbPb collisions carried out at a nucleon-nucleon (NN) centre-of-mass energy root S-NN of 2.76 TeV at the LHC using the CMS detector. In data corresponding to an integrated luminosity of 7.3 mu b(-1), the number of W -> mu v(mu) decays is extracted in the region of muon pseudorapidity vertical bar eta mu vertical bar < 2.1 and transverse momentum p(T)(mu) > 25 GeV/c. Yields of muons found per unit of pseudorapidity correspond to (159 +/- 10(stat.) +/- 12(syst.)) x 10(-8) W and (154 +/- 10(stat.) +/- 12(syst.)) x 10(-8) W- bosons per minimum-bias PbPb collision. The dependence of W production on the centrality of PbPb collisions is consistent with a scaling of the yield by the number of incoherent NN collisions. The yield of W bosons is also studied in a sample of pp interactions at root S = 2.76 TeV corresponding to an integrated luminosity of 231 nb(-1). The individual W+ and W- yields in PbPb and pp collisions are found to agree, once the neutron and proton content in Pb nuclei is taken into account. Likewise, the difference observed in the dependence of the positive and negative muon production on pseudorapidity is consistent with next-to-leading-order perturbative QCD calculations.
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- 2012
21. Social support buffers the effect of interpersonal life stress on suicidal ideation and self-injury during adolescence.
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Mackin, D. M., Perlman, G., Davila, J., Kotov, R., and Klein, D. N.
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AFFECTIVE disorders ,COUNSELING ,INTERPERSONAL relations ,INTERVIEWING ,LONGITUDINAL method ,PARENTS ,SELF-evaluation ,SELF-injurious behavior ,PSYCHOLOGICAL stress ,AFFINITY groups ,SOCIAL support ,SUICIDAL ideation - Abstract
BackgroundThe effect of life stress on suicidal symptoms during adolescence is well documented. Stressful life events can trigger suicidality, but most adolescents are resilient and it is unclear which factors protect against the deleterious impact of stress. Social support is thought to be one such factor. Therefore, we investigated the buffering effect of specific sources of social support (parental and peer) on life stress (interpersonal and non-interpersonal) in predicting suicidal symptoms during adolescence. In order to test the specificity of this stress buffering, we also examined it with regard to dysphoric mood.MethodData come from the Adolescent Development of Emotions and Personality Traits (ADEPT) Project, a cohort of 550 adolescent females aged 13.5–15.5 recruited from Long Island. Self-reported social support, suicidality, and dysphoria were assessed at baseline and suicidality and dysphoria were assessed again at 9-month follow-up. Life stress was assessed by interview at the follow-up.ResultsHigh levels of parental support protected adolescent girls from developing suicidal symptoms following a stressor. This effect was less pronounced for peer support. Also, social support did not buffer the pathogenic effects of non-interpersonal stress. Finally, social support did not buffer the effect of life stress on dysphoric symptoms.ConclusionsAltogether, our results highlight a distinct developmental pathway for the development of suicidal symptoms involving parental support that differs from the development of dysphoria, and signifies the importance and specificity of social support in protecting against suicidality in adolescent girls. [ABSTRACT FROM PUBLISHER]
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- 2017
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22. Building data marts to analyze university faculty activities using power BI
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Karabtsev Sergei, Kotov Roman, Davzit Ivan, and Gurov Evgeny
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Environmental sciences ,GE1-350 - Abstract
Evaluating the performance of university faculty is a hard task because of the diversity of the work performed. The authors assume that the founder of the university evaluates the effectiveness of the university according to performing the teaching staff. The aim of the study is to improve the monitoring of key performance indicators of the university teaching staff based on data management. The authors present an information system to support decision-making related to the teaching staff at Kemerovo State University. The authors of the paper describe creating such a system using Business Intelligence technologies step by step. The authors identified data sources, designed the structure of the data mart and built ETL-processes for its filling, implemented various analytical dashboards. Implementing the information system in the daily activities of the university allows responding promptly to changes in the key indicators, forecasting their further change, deciding on activation of efforts in the chosen direction or types of work.
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- 2023
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23. Neuroticism's prospective association with mental disorders halves after adjustment for baseline symptoms and psychiatric history, but the adjusted association hardly decays with time: a meta-analysis on 59 longitudinal/prospective studies with 443 ...
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Jeronimus, B. F., Kotov, R., Riese, H., and Ormel, J.
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ANXIETY , *MENTAL depression , *MENTAL illness , *META-analysis , *NEUROSES , *PATHOLOGICAL psychology , *SUBSTANCE abuse , *TIME , *SYSTEMATIC reviews - Abstract
BackgroundThis meta-analysis seeks to quantify the prospective association between neuroticism and the common mental disorders (CMDs, including anxiety, depression, and substance abuse) as well as thought disorders (psychosis/schizophrenia) and non-specific mental distress. Data on the degree of confounding of the prospective association of neuroticism by baseline symptoms and psychiatric history, and the rate of decay of neuroticism's effect over time, can inform theories about the structure of psychopathology and role of neuroticism, in particular the vulnerability theory.MethodThis meta-analysis included 59 longitudinal/prospective studies with 443 313 participants.ResultsThe results showed large unadjusted prospective associations between neuroticism and symptoms/diagnosis of anxiety, depression, and non-specific mental distress (d = 0.50–0.70). Adjustment for baseline symptoms and psychiatric history reduced the associations by half (d = 0.10–0.40). Unadjusted prospective associations for substance abuse and thought disorders/symptoms were considerably weaker (d = 0.03–0.20), but were not attenuated by adjustment for baseline problems. Unadjusted prospective associations were four times larger over short (<4 year) than long (⩾4 years) follow-up intervals, suggesting a substantial decay of the association with increasing time intervals. Adjusted effects, however, were only slightly larger over short v. long time intervals. This indicates that confounding by baseline symptoms and psychiatric history masks the long-term stability of the neuroticism vulnerability effect.ConclusionHigh neuroticism indexes a risk constellation that exists prior to the development and onset of any CMD. The adjusted prospective neuroticism effect remains robust and hardly decays with time. Our results underscore the need to focus on the mechanisms underlying this prospective association. [ABSTRACT FROM PUBLISHER]
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- 2016
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24. Emotion processing deficits and emotion-related disruption of working memory in psychotic disorders
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Sabharwal, A., Mukherjee, P., Szekely, A., Kotov, R., and Mohanty, A.
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- 2014
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25. Trajectory of cognitive functioning in psychosis: a 20 year follow-up study
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Rodriguez, I.R., Holzmacher, D., Allen, P., Stumper, A., Roger, R., Kotov, R., and Bromet, E.
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- 2013
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26. PTSD and risk for hypertension: a longitudinal analysis in WTC responders
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Pratt, L., Gonzalez, A., Kotov, R., and Luft, B.J.
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- 2013
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27. Dimensions of psychosis: validation of an empirical structure
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Allen, P., Holzmacher, D., Kotov, R., Xiao, H., Roger, R., and Bromet, E.
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- 2013
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28. Crystal Structure of Double Vanadates Ca[sub 9]R(VO[sub 4])[sub 7]. II. R = Tb, Dy, Ho, and Y.
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Belik, A. A., Morozov, V. A., Kotov, R. N., Khasanov, S. S., and Lazoryak, B. I.
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VANADATES ,CRYSTALS ,INORGANIC compounds - Abstract
Crystal structures of the compounds Ca[sub 9]R(VO[sub 4])[sub 7] (R = Tb (I), Dy (II), Ho (III), and Y (IV) have been studied by the method of the full-profile analysis. All the compounds are crystallized in the trigonal system (sp. gr. R3c, Z = 6) with the unit-cell parameters (I) a = 10.8592(1), c = 38.035(1), V= 3884.2(2) Å[sup 3]; (II) a = 10.8564(1), c = 38.009(1) Å, V = 3879.6(2) Å[sup 3], (III) a = 10.8565(1) and c = 37.995(1) Å, V= 3878.3(2) Å[sup 3], and (IV) a = 10.8588(1), c = 37.995(1) Å, V= 3879.9(2) Å[sup 3]. In structures I-IV, rare earth and calcium cations occupy three positions—M(1), M(2), and M(5). Rare earth cations occupy the R[sup 3+] positions almost in the same way: 2.7-2.6(2) cations in the M(1) position; 2.7-2.3(2) cations in the M(2) position, and 0.6-1.0(1) cation in the M(5) position. At the same time, the occupancy of the M(5) position regularly increases with a decrease of the R[sup 3+] radius. [ABSTRACT FROM AUTHOR]
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- 2000
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29. Crystal Structures of Double Calcium and Alkali Metal Phosphates Ca[sub 10]M(PO[sub 4])[sub 7](M=Li,Na,K).
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Morozov, V. A., Belik, A. A., Kotov, R. N., Presnyakov, I. A., Khasanov, S. S., and Lazoryak, B. I.
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CALCIUM ,ALKALI metals ,CRYSTALS ,RIETVELD refinement - Abstract
Crystal structures of double calcium and alkali metal phosphates described by the general formula Ca[sub 10]M(PO[sub 4])[sub 7](M=Li,Na,K) have been studied by the Rietveld method. The lattice parameters are a = 10.4203(1) and c = 37.389(1) Å (for M = Li), a = 10.4391(1) and c = 37.310(1) Å (for M = Na), and a = 10.4229(1) and c = 37.279(2) Å (for M = K); sp. gr. R3c,Z = 6. The specific features of the distribution of alkali metal cations over the structure positions are discussed. © 2000 MAIK “Nauka / Interperiodica”. [ABSTRACT FROM AUTHOR]
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- 2000
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30. Predictors of trajectories of illness course over 10 years in schizophrenia
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Sandler, J., Kotov, R., and Bromet, E.
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- 2011
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31. Effects of Amikacin on Maturation of the Auditory Analyzer in Rabbits.
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D'yakonova, I., Rakhmanova, I., Tikhomirov, A., Ishanova, Yu., and Kotov, R.
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LABORATORY rabbits ,HEARING ,BRAIN stem ,EVOKED potentials (Electrophysiology) ,DRUG efficacy - Abstract
We studied the dynamics of maturation of the hearing function by records of short-term latent brainstem evoked potentials and the effect of amikacin on maturation of the hearing function. The peripheral compartment of the auditory analyzer matures sooner than the central structures. Amikacin in therapeutic doses exhibited an ototoxic effect on the peripheral compartment of the auditory analyzer without impairing its central structures. [ABSTRACT FROM AUTHOR]
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- 2011
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32. Reduction and Re-Oxidation Behavior of Calcium Iron Phosphate, Ca9Fe(PO4)7.
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Lazoryak, B. I., Belik, A. A., Kotov, R. N., Leonidov, I. A., Mitberg, E. B., Karelina, V. V., Kellerman, D. G., Stefanovich, S. Yu., and Avetisov, A. K.
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- 2003
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33. ChemInform Abstract: Crystal Structure of Ca19Ce(PO4)14.
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LAZORYAK, B. I., KOTOV, R. N., and KHASANOV, S. S.
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- 1997
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34. Ultra-Rare Genetic Variation in the Epilepsies: A Whole-Exome Sequencing Study of 17,606 Individuals
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Yen-Chen Anne Feng, Daniel P. Howrigan, Liam E. Abbott, Katherine Tashman, Felecia Cerrato, Tarjinder Singh, Henrike Heyne, Andrea Byrnes, Claire Churchhouse, Nick Watts, Matthew Solomonson, Dennis Lal, Erin L. Heinzen, Ryan S. Dhindsa, Kate E. Stanley, Gianpiero L. Cavalleri, Hakon Hakonarson, Ingo Helbig, Roland Krause, Patrick May, Sarah Weckhuysen, Slavé Petrovski, Sitharthan Kamalakaran, Sanjay M. Sisodiya, Patrick Cossette, Chris Cotsapas, Peter De Jonghe, Tracy Dixon-Salazar, Renzo Guerrini, Patrick Kwan, Anthony G. Marson, Randy Stewart, Chantal Depondt, Dennis J. Dlugos, Ingrid E. Scheffer, Pasquale Striano, Catharine Freyer, Kevin McKenna, Brigid M. Regan, Susannah T. Bellows, Costin Leu, Caitlin A. Bennett, Esther M.C. Johns, Alexandra Macdonald, Hannah Shilling, Rosemary Burgess, Dorien Weckhuysen, Melanie Bahlo, Terence J. O’Brien, Marian Todaro, Hannah Stamberger, Danielle M. Andrade, Tara R. Sadoway, Kelly Mo, Heinz Krestel, Sabina Gallati, Savvas S. Papacostas, Ioanna Kousiappa, George A. Tanteles, Katalin Štěrbová, Markéta Vlčková, Lucie Sedláčková, Petra Laššuthová, Karl Martin Klein, Felix Rosenow, Philipp S. Reif, Susanne Knake, Wolfram S. Kunz, Gábor Zsurka, Christian E. Elger, Jürgen Bauer, Michael Rademacher, Manuela Pendziwiat, Hiltrud Muhle, Annika Rademacher, Andreas van Baalen, Sarah von Spiczak, Ulrich Stephani, Zaid Afawi, Amos D. Korczyn, Moien Kanaan, Christina Canavati, Gerhard Kurlemann, Karen Müller-Schlüter, Gerhard Kluger, Martin Häusler, Ilan Blatt, Johannes R. Lemke, Ilona Krey, Yvonne G. Weber, Stefan Wolking, Felicitas Becker, Christian Hengsbach, Sarah Rau, Ana F. Maisch, Bernhard J. Steinhoff, Andreas Schulze-Bonhage, Susanne Schubert-Bast, Herbert Schreiber, Ingo Borggräfe, Christoph J. Schankin, Thomas Mayer, Rudolf Korinthenberg, Knut Brockmann, Dieter Dennig, Rene Madeleyn, Reetta Kälviäinen, Pia Auvinen, Anni Saarela, Tarja Linnankivi, Anna-Elina Lehesjoki, Mark I. Rees, Seo-Kyung Chung, William O. Pickrell, Robert Powell, Natascha Schneider, Simona Balestrini, Sara Zagaglia, Vera Braatz, Michael R. Johnson, Pauls Auce, Graeme J. Sills, Larry W. Baum, Pak C. Sham, Stacey S. Cherny, Colin H.T. Lui, Nina Barišić, Norman Delanty, Colin P. Doherty, Arif Shukralla, Mark McCormack, Hany El-Naggar, Laura Canafoglia, Silvana Franceschetti, Barbara Castellotti, Tiziana Granata, Federico Zara, Michele Iacomino, Francesca Madia, Maria Stella Vari, Maria Margherita Mancardi, Vincenzo Salpietro, Francesca Bisulli, Paolo Tinuper, Laura Licchetta, Tommaso Pippucci, Carlotta Stipa, Raffaella Minardi, Antonio Gambardella, Angelo Labate, Grazia Annesi, Lorella Manna, Monica Gagliardi, Elena Parrini, Davide Mei, Annalisa Vetro, Claudia Bianchini, Martino Montomoli, Viola Doccini, Carla Marini, Toshimitsu Suzuki, Yushi Inoue, Kazuhiro Yamakawa, Birute Tumiene, Lynette G. Sadleir, Chontelle King, Emily Mountier, S. Hande Caglayan, Mutluay Arslan, Zuhal Yapıcı, Uluc Yis, Pınar Topaloglu, Bulent Kara, Dilsad Turkdogan, Aslı Gundogdu-Eken, Nerses Bebek, Sibel Uğur-İşeri, Betül Baykan, Barış Salman, Garen Haryanyan, Emrah Yücesan, Yeşim Kesim, Çiğdem Özkara, Annapurna Poduri, Beth R. Shiedley, Catherine Shain, Russell J. Buono, Thomas N. Ferraro, Michael R. Sperling, Warren Lo, Michael Privitera, Jacqueline A. French, Steven Schachter, Ruben I. Kuzniecky, Orrin Devinsky, Manu Hegde, Pouya Khankhanian, Katherine L. Helbig, Colin A. Ellis, Gianfranco Spalletta, Fabrizio Piras, Federica Piras, Tommaso Gili, Valentina Ciullo, Andreas Reif, Andrew McQuillin, Nick Bass, Andrew McIntosh, Douglas Blackwood, Mandy Johnstone, Aarno Palotie, Michele T. Pato, Carlos N. Pato, Evelyn J. Bromet, Celia Barreto Carvalho, Eric D. Achtyes, Maria Helena Azevedo, Roman Kotov, Douglas S. Lehrer, Dolores Malaspina, Stephen R. Marder, Helena Medeiros, Christopher P. Morley, Diana O. Perkins, Janet L. Sobell, Peter F. Buckley, Fabio Macciardi, Mark H. Rapaport, James A. Knowles, Ayman H. Fanous, Steven A. McCarroll, Namrata Gupta, Stacey B. Gabriel, Mark J. Daly, Eric S. Lander, Daniel H. Lowenstein, David B. Goldstein, Holger Lerche, Samuel F. Berkovic, Benjamin M. Neale, Wellcome Trust, Department of Health, Institute of Neurology, UCL, Imperial College Healthcare NHS Trust- BRC Funding, Commission of the European Communities, Medical Research Council (MRC), Feng Y.-C.A., Howrigan D.P., Abbott L.E., Tashman K., Cerrato F., Singh T., Heyne H., Byrnes A., Churchhouse C., Watts N., Solomonson M., Lal D., Heinzen E.L., Dhindsa R.S., Stanley K.E., Cavalleri G.L., Hakonarson H., Helbig I., Krause R., May P., Weckhuysen S., Petrovski S., Kamalakaran S., Sisodiya S.M., Cossette P., Cotsapas C., De Jonghe P., Dixon-Salazar T., Guerrini R., Kwan P., Marson A.G., Stewart R., Depondt C., Dlugos D.J., Scheffer I.E., Striano P., Freyer C., McKenna K., Regan B.M., Bellows S.T., Leu C., Bennett C.A., Johns E.M.C., Macdonald A., Shilling H., Burgess R., Weckhuysen D., Bahlo M., O'Brien T.J., Todaro M., Stamberger H., Andrade D.M., Sadoway T.R., Mo K., Krestel H., Gallati S., Papacostas S.S., Kousiappa I., Tanteles G.A., Sterbova K., Vlckova M., Sedlackova L., Lassuthova P., Klein K.M., Rosenow F., Reif P.S., Knake S., Kunz W.S., Zsurka G., Elger C.E., Bauer J., Rademacher M., Pendziwiat M., Muhle H., Rademacher A., van Baalen A., von Spiczak S., Stephani U., Afawi Z., Korczyn A.D., Kanaan M., Canavati C., Kurlemann G., Muller-Schluter K., Kluger G., Hausler M., Blatt I., Lemke J.R., Krey I., Weber Y.G., Wolking S., Becker F., Hengsbach C., Rau S., Maisch A.F., Steinhoff B.J., Schulze-Bonhage A., Schubert-Bast S., Schreiber H., Borggrafe I., Schankin C.J., Mayer T., Korinthenberg R., Brockmann K., Dennig D., Madeleyn R., Kalviainen R., Auvinen P., Saarela A., Linnankivi T., Lehesjoki A.-E., Rees M.I., Chung S.-K., Pickrell W.O., Powell R., Schneider N., Balestrini S., Zagaglia S., Braatz V., Johnson M.R., Auce P., Sills G.J., Baum L.W., Sham P.C., Cherny S.S., Lui C.H.T., Barisic N., Delanty N., Doherty C.P., Shukralla A., McCormack M., El-Naggar H., Canafoglia L., Franceschetti S., Castellotti B., Granata T., Zara F., Iacomino M., Madia F., Vari M.S., Mancardi M.M., Salpietro V., Bisulli F., Tinuper P., Licchetta L., Pippucci T., Stipa C., Minardi R., Gambardella A., Labate A., Annesi G., Manna L., Gagliardi M., Parrini E., Mei D., Vetro A., Bianchini C., Montomoli M., Doccini V., Marini C., Suzuki T., Inoue Y., Yamakawa K., Tumiene B., Sadleir L.G., King C., Mountier E., Caglayan S.H., Arslan M., Yapici Z., Yis U., Topaloglu P., Kara B., Turkdogan D., Gundogdu-Eken A., Bebek N., Ugur-Iseri S., Baykan B., Salman B., Haryanyan G., Yucesan E., Kesim Y., Ozkara C., Poduri A., Shiedley B.R., Shain C., Buono R.J., Ferraro T.N., Sperling M.R., Lo W., Privitera M., French J.A., Schachter S., Kuzniecky R.I., Devinsky O., Hegde M., Khankhanian P., Helbig K.L., Ellis C.A., Spalletta G., Piras F., Gili T., Ciullo V., Reif A., McQuillin A., Bass N., McIntosh A., Blackwood D., Johnstone M., Palotie A., Pato M.T., Pato C.N., Bromet E.J., Carvalho C.B., Achtyes E.D., Azevedo M.H., Kotov R., Lehrer D.S., Malaspina D., Marder S.R., Medeiros H., Morley C.P., Perkins D.O., Sobell J.L., Buckley P.F., Macciardi F., Rapaport M.H., Knowles J.A., Fanous A.H., McCarroll S.A., Gupta N., Gabriel S.B., Daly M.J., Lander E.S., Lowenstein D.H., Goldstein D.B., Lerche H., Berkovic S.F., Neale B.M., Epi25 Collaborative, YÜCESAN, EMRAH, Institute for Molecular Medicine Finland, Children's Hospital, HUS Children and Adolescents, Department of Medical and Clinical Genetics, University Management, Centre of Excellence in Complex Disease Genetics, Aarno Palotie / Principal Investigator, and Genomics of Neurological and Neuropsychiatric Disorders
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s.berkovic@unimelb.edu.au [Epi25 Collaborative. Electronic address] ,0301 basic medicine ,GAMMA-2-SUBUNIT ,burden analysi ,DNA Mutational Analysis ,PROTEIN ,Neurodegenerative ,VARIANTS ,SUSCEPTIBILITY ,Medical and Health Sciences ,Epilepsy ,0302 clinical medicine ,2.1 Biological and endogenous factors ,EPIDEMIOLOGY ,Missense mutation ,Exome ,Aetiology ,Genetics (clinical) ,Exome sequencing ,11 Medical and Health Sciences ,seizures ,GABRG2 ,Genetics ,Genetics & Heredity ,0303 health sciences ,biology ,COMMON EPILEPSIES ,1184 Genetics, developmental biology, physiology ,sequencing ,Biological Sciences ,Epi25 Collaborative ,Phenotype ,GENOME ,epileptic encephalopathy ,burden analysis ,Neurological ,Biotechnology ,Genetic Markers ,seizure ,EEF1A2 ,Burden analysis ,epilepsy ,exome ,Article ,03 medical and health sciences ,Clinical Research ,Exome Sequencing ,Genetic variation ,medicine ,Humans ,Genetic Predisposition to Disease ,Gene ,EPILEPTIC SEIZURES ,METAANALYSIS ,030304 developmental biology ,Human Genome ,Neurosciences ,Genetic Variation ,06 Biological Sciences ,medicine.disease ,Brain Disorders ,030104 developmental biology ,Genetic marker ,DE-NOVO MUTATIONS ,Case-Control Studies ,biology.protein ,3111 Biomedicine ,Human medicine ,030217 neurology & neurosurgery - Abstract
Sequencing-based studies have identified novel risk genes for rare, severe epilepsies and revealed a role of rare deleterious variation in common epilepsies. To identify the shared and distinct ultra-rare genetic risk factors for rare and common epilepsies, we performed a whole-exome sequencing (WES) analysis of 9,170 epilepsy-affected individuals and 8,364 controls of European ancestry. We focused on three phenotypic groups; the rare but severe developmental and epileptic encephalopathies (DEE), and the commoner phenotypes of genetic generalized epilepsy (GGE) and non-acquired focal epilepsy (NAFE). We observed that compared to controls, individuals with any type of epilepsy carried an excess of ultra-rare, deleterious variants in constrained genes and in genes previously associated with epilepsy, with the strongest enrichment seen in DEE and the least in NAFE. Moreover, we found that inhibitory GABAA receptor genes were enriched for missense variants across all three classes of epilepsy, while no enrichment was seen in excitatory receptor genes. The larger gene groups for the GABAergic pathway or cation channels also showed a significant mutational burden in DEE and GGE. Although no single gene surpassed exome-wide significance among individuals with GGE or NAFE, highly constrained genes and genes encoding ion channels were among the top associations, including CACNA1G, EEF1A2, and GABRG2 for GGE and LGI1, TRIM3, and GABRG2 for NAFE. Our study confirms a convergence in the genetics of common and rare epilepsies associated with ultra-rare coding variation and highlights a ubiquitous role for GABAergic inhibition in epilepsy etiology in the largest epilepsy WES study to date.
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- 2019
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35. The hierarchical taxonomy of psychopathology and the search for neurobiological substrates of mental illness: A systematic review and roadmap for future research.
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DeYoung CG, Blain SD, Latzman RD, Grazioplene RG, Haltigan JD, Kotov R, Michelini G, Venables NC, Docherty AR, Goghari VM, Kallen AM, Martin EA, Palumbo IM, Patrick CJ, Perkins ER, Shackman AJ, Snyder ME, and Tobin KE
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- Humans, Neuroimaging methods, Mental Disorders classification, Mental Disorders physiopathology, Mental Disorders diagnosis, Psychopathology
- Abstract
Understanding the neurobiological mechanisms involved in psychopathology has been hindered by the limitations of categorical nosologies. The Hierarchical Taxonomy of Psychopathology (HiTOP) is an alternative dimensional system for characterizing psychopathology, derived from quantitative studies of covariation among diagnoses and symptoms. HiTOP provides more promising targets for clinical neuroscience than traditional psychiatric diagnoses and can facilitate cumulative integration of existing research. We systematically reviewed 164 human neuroimaging studies with sample sizes of 194 or greater that have investigated dimensions of psychopathology classified within HiTOP. Replicated results were identified for constructs at five different levels of the hierarchy, including the overarching p-factor, the externalizing superspectrum, the thought disorder and internalizing spectra, the distress subfactor, and the depression symptom dimension. Our review highlights the potential of dimensional clinical neuroscience research and the usefulness of HiTOP while also suggesting limitations of existing work in this relatively young field. We discuss how HiTOP can be integrated synergistically with neuroscience-oriented, transdiagnostic frameworks developed by the National Institutes of Health, including the Research Domain Criteria, Addictions Neuroclinical Assessment, and the National Institute on Drug Abuse's Phenotyping Assessment Battery, and how researchers can use HiTOP to accelerate clinical neuroscience research in humans and other species. (PsycInfo Database Record (c) 2024 APA, all rights reserved).
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- 2024
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36. State of the Science: The Hierarchical Taxonomy of Psychopathology (HiTOP).
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Cicero DC, Ruggero CJ, Balling CE, Bottera AR, Cheli S, Elkrief L, Forbush KT, Hopwood CJ, Jonas KG, Jutras-Aswad D, Kotov R, Levin-Aspenson HF, Mullins-Sweatt SN, Johnson-Munguia S, Narrow WE, Negi S, Patrick CJ, Rodriguez-Seijas C, Sheth S, Simms LJ, and Thomeczek ML
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- Humans, Self Report, Mental Disorders classification, Mental Disorders diagnosis, Mental Disorders psychology, Psychopathology
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The Hierarchical Taxonomy of Psychopathology (HiTOP) is a dimensional framework for psychopathology advanced by a consortium of nosologists. In the HiTOP system, psychopathology is grouped hierarchically from super-spectra, spectra, and subfactors at the upper levels to homogeneous symptom components and maladaptive traits and their constituent symptoms, and maladaptive behaviors at the lower levels. HiTOP has the potential to improve clinical outcomes by planning treatment based on symptom severity rather than heterogeneous diagnoses, targeting treatment across different levels of the hierarchy, and assessing distress and impairment separately from the observed symptom profile. Assessments can be performed according to this framework with the recently developed HiTOP-Self-Report (HiTOP-SR). Examples of how to use HiTOP in clinical practice are provided for the internalizing spectrum, including the use of the Unified Protocol and other modularized treatments, measurement-based care, psychopharmacology, and in traditionally underserved populations. Future directions are discussed in this State of the Science review including HiTOP's use in further developing transdiagnostic treatments, extending the model to include other information such as environmental factors, establishing the treatment utility of clinical assessment for the HiTOP-SR, developing new treatments, and disseminating the model., (Copyright © 2024 Association for Behavioral and Cognitive Therapies. Published by Elsevier Ltd. All rights reserved.)
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- 2024
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37. Association of Neuromelanin-Sensitive MRI Signal With Lifetime Substance Use in Young Women.
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Perlman G, Wengler K, Moeller SJ, Kotov R, Klein DN, Weinstein JJ, Horga G, and Abi-Dargham A
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- Humans, Female, Young Adult, Male, Reward, Ventral Tegmental Area diagnostic imaging, Ventral Tegmental Area metabolism, Mesencephalon metabolism, Mesencephalon diagnostic imaging, Dopamine metabolism, Adult, Magnetic Resonance Imaging, Melanins metabolism, Substance-Related Disorders metabolism, Substance-Related Disorders diagnostic imaging, Substantia Nigra diagnostic imaging, Substantia Nigra metabolism
- Abstract
Objective: Midbrain dopamine function plays a key role in translational models of substance use disorders. Whether midbrain dopamine function is associated with substance use frequency and severity or reward function in 20-24 year-olds remains a critical gap in knowledge. The authors collected neuromelanin-sensitive magnetic resonance imaging (NM-MRI), a validated index of lifetime dopamine function in the substantia nigra/ventral tegmentum area (SN-VTA) complex, to characterize altered dopamine function., Method: Midbrain NM-MRI contrast-to-noise ratio (CNR) was acquired in 135 20-24 year-olds (105 women and 30 men). A composite measure of cumulative substance use was derived from factor analysis of lifetime alcohol intoxications, lifetime cannabis use, use of nicotine in heaviest month, number of classes of drugs used, and ever meeting DSM-5 criteria for a SUD. Trait reward function was assessed by self-report., Results: Cumulative substance use was significantly positively associated with NM-MRI CNR in a large area of the bilateral SN-VTA complex, an effect which was driven by women (who comprised most of the sample) and by voxels with greater NM-MRI CNR, including the ventral tegmentum area. NM-MRI CNR was not associated with individual differences in trait reward function., Conclusions: History of substance use is associated with greater NM signal in NM-rich areas of the midbrain, especially in women. Future longitudinal studies with repeated NM-MRI assessments, especially in younger cohorts and while including more men, are warranted to evaluate whether aberrant dopamine function predates, follows, or is modulated by substance use., Competing Interests: Dr. Abi-Dargham serves on the Scientific Advisory Board for Neurocrine, Sunovion, and Abbvie; on the Data Safety Monitoring Board for Merck; and as the Deputy Editor of Biological Psychiatry; holds stock options in Herophilus and Terran Life Sciences; and has received consulting fees/honoraria from Boehringer Ingelheim, Merck, Neurocrine, Otsuka, Roche, and Sunovion. Dr Horga reports an investigator-initiated sponsored research agreement from Terran Biosciences outside the submitted work and having filed patents for the analysis and use of neuromelanin-sensitive magnetic resonance imaging in central nervous system disorders licensed to Terran Biosciences with no royalties received (WO2021034770A1, WO2022192728A3, AU2021377338A1, AU2019359377A1). Dr Wengler reports having filed patents for the analysis and use of neuromelanin-sensitive magnetic resonance imaging in central nervous system disorders licensed to Terran Biosciences with no royalties received (WO2021034770A1, WO2022192728A3, AU2021377338A1). The remaining authors report no financial relationships with commercial interests.
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- 2024
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38. Digital assessment of nonverbal behaviors forecasts first onset of depression.
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Ozturk S, Feltman S, Klein DN, Kotov R, and Mohanty A
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Background: Adolescence is marked by a sharp increase in the incidence of depression, especially in females. Identification of risk for depressive disorders (DD) in this key developmental stage can help prevention efforts, mitigating the clinical and public burden of DD. While frequently used in diagnosis, nonverbal behaviors are relatively understudied as risk markers for DD. Digital technology, such as facial recognition, may provide objective, fast, efficient, and cost-effective means of measuring nonverbal behavior., Method: Here, we analyzed video-recorded clinical interviews of 359 never-depressed adolescents females via commercially available facial emotion recognition software., Results: We found that average head and facial movements forecast future first onset of depression (AUC = 0.70) beyond the effects of other established self-report and physiological markers of DD risk., Conclusions: Overall, these findings suggest that digital assessment of nonverbal behaviors may provide a promising risk marker for DD, which could aid in early identification and intervention efforts.
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- 2024
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39. Where do neurodevelopmental conditions fit in transdiagnostic psychiatric frameworks? Incorporating a new neurodevelopmental spectrum.
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Michelini G, Carlisi CO, Eaton NR, Elison JT, Haltigan JD, Kotov R, Krueger RF, Latzman RD, Li JJ, Levin-Aspenson HF, Salum GA, South SC, Stanton K, Waldman ID, and Wilson S
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Features of autism spectrum disorder, attention-deficit/hyperactivity disorder, learning disorders, intellectual disabilities, and communication and motor disorders usually emerge early in life and are associated with atypical neurodevelopment. These "neurodevelopmental conditions" are grouped together in the DSM-5 and ICD-11 to reflect their shared characteristics. Yet, reliance on categorical diagnoses poses significant challenges in both research and clinical settings (e.g., high co-occurrence, arbitrary diagnostic boundaries, high within-disorder heterogeneity). Taking a transdiagnostic dimensional approach provides a useful alternative for addressing these limitations, accounting for shared underpinnings across neurodevelopmental conditions, and characterizing their common co-occurrence and developmental continuity with other psychiatric conditions. Neurodevelopmental features have not been adequately considered in transdiagnostic psychiatric frameworks, although this would have fundamental implications for research and clinical practices. Growing evidence from studies on the structure of neurodevelopmental and other psychiatric conditions indicates that features of neurodevelopmental conditions cluster together, delineating a "neurodevelopmental spectrum" ranging from normative to impairing profiles. Studies on shared genetic underpinnings, overlapping cognitive and neural profiles, and similar developmental course and efficacy of support/treatment strategies indicate the validity of this neurodevelopmental spectrum. Further, characterizing this spectrum alongside other psychiatric dimensions has clinical utility, as it provides a fuller view of an individual's needs and strengths, and greater prognostic utility than diagnostic categories. Based on this compelling body of evidence, we argue that incorporating a new neurodevelopmental spectrum into transdiagnostic frameworks has considerable potential for transforming our understanding, classification, assessment, and clinical practices around neurodevelopmental and other psychiatric conditions., (© 2024 World Psychiatric Association.)
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- 2024
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40. Error-related brain activity shapes the association between trait neuroticism and internalizing symptomatology in two tasks.
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Harold R, Hill KE, Kamat R, Perlman G, Kotov R, Ruggero CJ, Samuel DB, and Foti D
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- Humans, Male, Female, Young Adult, Adolescent, Adult, Evoked Potentials physiology, Brain physiopathology, Brain physiology, Reaction Time physiology, Psychomotor Performance physiology, Neuroticism physiology, Electroencephalography, Anxiety Disorders physiopathology
- Abstract
The current study examined how individual differences in error-related brain activity might moderate the association between high trait neuroticism and internalizing symptoms. Data were collected from a sample of high-achieving young adults (N = 188) as part of a larger study on risk versus resiliency for psychopathology. Participants completed two behavioral tasks to elicit the error-related negativity (ERN): an arrow Flanker task and a Go/No-Go task. Analyses were constrained to two internalizing symptom dimensions of checking behavior and irritability. Contrary to expectations, ERN amplitude was not related to symptom severity at the bivariate level. However, ERN amplitude moderated the association between trait neuroticism and symptoms of ill temper, such that the neuroticism-irritability association was strongest among individuals with a blunted ERN. In addition, this finding was relatively consistent across tasks and across two complementary methods of scoring the ERN, suggesting an effect of ERN variance that is shared between tasks and that is relatively robust regarding processing differences. In all, the current study represents the first attempt to investigate how the ERN interacts with trait neuroticism to predict transdiagnostic symptom dimensions in adulthood., (Copyright © 2024 Elsevier B.V. All rights reserved.)
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- 2024
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41. Exploring the genetic etiology across the continuum of the general psychopathology factor: a Swedish population-based family and twin study.
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Liu Y, Lichtenstein P, Kotov R, Larsson H, D'Onofrio BM, and Pettersson E
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- Humans, Male, Female, Sweden epidemiology, Adult, Registries, Siblings, Middle Aged, Genetic Predisposition to Disease genetics, Family, Comorbidity, Diseases in Twins genetics, Twins genetics, Twins, Monozygotic genetics, Mental Disorders genetics, Mental Disorders epidemiology, Psychopathology methods
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Psychiatric comorbidity can be accounted for by a latent general psychopathology factor (p factor), which quantifies the variance that is shared to varying degrees by every dimension of psychopathology. It is unclear whether the entire continuum of the p factor shares the same genetic origin. We investigated whether mild, moderate, and extreme elevations on the p factor shared the same genetic etiology by, first, examining the linearity of the association between p factors across siblings (N = 580,891 pairs). Second, we estimated the group heritability in a twin sample (N = 17,170 pairs), which involves testing whether the same genetic variants influence both extreme and normal variations in the p factor. In both samples, the p factor was based on 10 register-based psychiatric diagnoses. Results showed that the association between siblings' p factors appeared linear, even into the extreme range. Likewise, the twin group heritabilities ranged from 0.42 to 0.45 (95% CI: 0.33-0.57) depending on the thresholds defining the probands (2-3.33 SD beyond the mean; >2 SD beyond the mean; >4.33 SD beyond the mean; and >5.33 SD beyond the mean), and these estimates were highly similar to the estimated individual differences heritability (0.41, 95% CI: 0.39-0.43), indicating that scores above and below these thresholds shared a common genetic origin. Together, these results suggest that the entire continuum of the p factor shares the same genetic origin, with common genetic variants likely playing an important role. This implies, first, genetic risk factors for the aspect that is shared between all forms of psychopathology (i.e., genetic risk factors for the p factor) might be generalizable between population-based cohorts with a higher prevalence of milder cases, and clinical samples with a preponderance of more severe cases. Second, prioritizing low-cost genome-wide association studies capable of identifying common genetic variants, rather than expensive whole genome sequencing that can identify rare variants, may increase the efficiency when studying the genetic architecture of the p factor., (© 2024. The Author(s).)
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- 2024
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42. Sleep disturbances across two weeks predict future mental healthcare utilization.
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Slavish DC, Ruggero CJ, Luft B, and Kotov R
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Study Objectives: Insufficient sleep costs the U.S. economy over $411 billion per year. However, most studies investigating economic costs of sleep rely on one-time measures of sleep, which may be prone to recall bias and cannot capture variability in sleep. To address these gaps, we examined how sleep metrics captured from daily sleep diaries predicted medical expenditures., Methods: Participants were 391 World Trade Center responders enrolled in the World Trade Center Health Program (mean age = 54.97 years, 89% men). At baseline, participants completed 14 days of self-reported sleep and stress measures. Mean sleep, variability in sleep, and a novel measure of sleep reactivity (i.e., how much people's sleep changes in response to daily stress) were used to predict the subsequent year's medical expenditures, covarying for age, race/ethnicity, sex, medical diagnoses, and body mass index., Results: Mean sleep efficiency did not predict mental healthcare utilization. However, greater sleep efficiency reactivity to stress (b=$191.75, p=.027), sleep duration reactivity to stress (b=$206.33, p=.040), variability in sleep efficiency (b=$339.33, p=.002), variability in sleep duration (b=$260.87, p=.004), and quadratic mean sleep duration (b=$182.37, p=.001) all predicted greater mental healthcare expenditures. Together, these sleep variables explained 12% of the unique variance in mental healthcare expenditures. No sleep variables were significantly associated with physical healthcare expenditures., Conclusions: People with more irregular sleep, more sleep reactivity, and either short or long sleep engage in more mental healthcare utilization. It may be important to address these individuals' sleep problems to improve mental health and reduce healthcare costs., (© The Author(s) 2024. Published by Oxford University Press on behalf of Sleep Research Society. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.)
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- 2024
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43. Measurement invariance of the Child Behavior Checklist (CBCL) across race/ethnicity and sex in the Adolescent Brain and Cognitive Development (ABCD) study.
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Stewart LC, Asadi S, Rodriguez-Seijas C, Wilson S, Michelini G, Kotov R, Cicero DC, and Olino TM
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- Humans, Child, Female, Male, Ethnicity psychology, Adolescent, Child Behavior psychology, Psychometrics, Sex Factors, Adolescent Development, Child Behavior Disorders psychology, Child Behavior Disorders diagnosis, Child Behavior Disorders ethnology, Checklist
- Abstract
There are numerous studies examining differences in the experience of disorders and symptoms of psychopathology in adolescents across racial or ethnic groups and sex. Though there is substantial research exploring potential factors that may influence these differences, few studies have considered the potential contribution of measurement properties to these differences. Therefore, this study examined whether there are differences across racial or ethnic groups and sex in the measurement of psychopathology, assessed in mother-reported behavior of 9-11 year old youth from the Adolescent Brain Cognitive Development study sample using updated Child Behavior Checklist scales (CBCL; Achenbach & Rescorla, 2001). Tests of measurement invariance of the CBCL utilized the higher order factor structure identified by Michelini et al. (2019) using this same Adolescent Brain Cognitive Development cohort. The dimensions include internalizing, somatoform, detachment, externalizing, and neurodevelopmental problems. The configural model had a good-to-excellent fit on all subscales of the CBCL across racial or ethnic groups and sex. The metric and scalar models fit just as well as the configural models, indicating that the scales are measuring the same constructs across racial or ethnic groups and sex and are not influenced by measurement properties of items on the CBCL, although some high-severity response options were not endorsed for youth in all racial or ethnic groups. These findings support the use of the CBCL in research examining psychopathology in racially or ethnically diverse samples of youth. (PsycInfo Database Record (c) 2024 APA, all rights reserved).
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- 2024
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44. The Prospective Predictive Power of Parent-Reported Personality Traits and Facets in First-Onset Depression in Adolescent Girls.
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Zhong Y, Perlman G, Klein DN, Jin J, and Kotov R
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- Humans, Female, Adolescent, Prospective Studies, Depression psychology, Depression epidemiology, Depression diagnosis, Self Report, Risk Factors, Depressive Disorder psychology, Depressive Disorder diagnosis, Depressive Disorder epidemiology, Personality, Parents psychology
- Abstract
Certain personality traits and facets are well-known risk factors that predict first-onset depression during adolescence. However, prior research predominantly relied on self-reported data, which has limitations as a source of personality information. Reports from close informants have the potential to increase the predictive power of personality on first-onsets of depression in adolescents. With easy access to adolescents' behaviors across settings and time, parents may provide important additional information about their children's personality. The same personality trait(s) and facet(s) rated by selves (mean age 14.4 years old) and biological parents at baseline were used to prospectively predict depression onsets among 442 adolescent girls during a 72-month follow-up. First, bivariate logistic regression was used to examine whether parent-reported personality measures predicted adolescent girls' depression onsets; then multivariate logistic regression was used to test whether parent reports provided additional predictive power above and beyond self-reports of same trait or facet. Parent-reported personality traits and facets predicted adolescents' depression onsets, similar to findings using self-reported data. After controlling for the corresponding self-report measures, parent-reported higher openness (at the trait level) and higher depressivity (at the facet-level) incrementally predicted first-onset of depression in the sample. Findings demonstrated additional variance contributed by parent-reported personality measures and validated a multi-informant approach in using personality to prospectively predict onsets of depression in adolescent girls., (© 2024. The Author(s).)
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- 2024
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45. Behavioral meaures of psychotic disorders: Using automatic facial coding to detect nonverbal expressions in video.
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Martin EA, Lian W, Oltmanns JR, Jonas KG, Samaras D, Hallquist MN, Ruggero CJ, Clouston SAP, and Kotov R
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- Humans, Female, Male, Adult, Middle Aged, Schizophrenia physiopathology, Schizophrenia diagnosis, Psychiatric Status Rating Scales, Head Movements physiology, Young Adult, Emotions physiology, Psychotic Disorders physiopathology, Psychotic Disorders diagnosis, Facial Expression, Video Recording
- Abstract
Emotional deficits in psychosis are prevalent and difficult to treat. In particular, much remains unknown about facial expression abnormalities, and a key reason is that expressions are very labor-intensive to code. Automatic facial coding (AFC) can remove this barrier. The current study sought to both provide evidence for the utility of AFC in psychosis for research purposes and to provide evidence that AFC are valid measures of clinical constructs. Changes of facial expressions and head position of participants-39 with schizophrenia/schizoaffective disorder (SZ), 46 with other psychotic disorders (OP), and 108 never psychotic individuals (NP)-were assessed via FaceReader, a commercially available automated facial expression analysis software, using video recorded during a clinical interview. We first examined the behavioral measures of the psychotic disorder groups and tested if they can discriminate between the groups. Next, we evaluated links of behavioral measures with clinical symptoms, controlling for group membership. We found the SZ group was characterized by significantly less variation in neutral expressions, happy expressions, arousal, and head movements compared to NP. These measures discriminated SZ from NP well (AUC = 0.79, sensitivity = 0.79, specificity = 0.67) but discriminated SZ from OP less well (AUC = 0.66, sensitivity = 0.77, specificity = 0.46). We also found significant correlations between clinician-rated symptoms and most behavioral measures (particularly happy expressions, arousal, and head movements). Taken together, these results suggest that AFC can provide useful behavioral measures of psychosis, which could improve research on non-verbal expressions in psychosis and, ultimately, enhance treatment., Competing Interests: Declaration of competing interest None., (Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)
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- 2024
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46. Reconceptualizing mental health in cancer survivorship.
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Haywood D, Kotov R, Krueger RF, Wright AGC, Forbes MK, Dauer E, Baughman FD, Rossell SL, and Hart NH
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- Humans, Survivorship, Cancer Survivors psychology, Cancer Survivors statistics & numerical data, Mental Health statistics & numerical data, Neoplasms psychology, Neoplasms therapy, Neoplasms mortality, Mental Disorders psychology, Mental Disorders epidemiology, Mental Disorders therapy
- Abstract
Mental health for cancer survivors in both research and clinical applications has strongly adopted a traditional nosological approach, involving the classification of psychopathology into discrete disorders. However, this approach has recently faced considerable criticism due to issues such as high comorbidity and within-disorder symptom heterogeneity across populations. Moreover, there are additional specific issues impacting the validity of traditional approaches in cancer survivorship populations, including the physiological effects of cancer and its treatments. In response, we provide the case for the hierarchical dimensional approach within psycho-oncology, in particular the Hierarchical Taxonomy of Psychopathology (HiTOP). We discuss not only the potential utility of HiTOP to research and clinical applications within psycho-oncology, but also its limitations, and what is required to apply this approach within cancer survivorship., Competing Interests: Declaration of interests D.H., R.K., R.F.K., A.G.C.W., and M.K.F. are members of the HiTOP Consortium. Otherwise, the authors declare no conflicts of interest., (Copyright © 2024 Elsevier Inc. All rights reserved.)
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- 2024
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47. A Transdiagnostic, Hierarchical Taxonomy of Psychopathology Following Traumatic Brain Injury (HiTOP-TBI).
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Carmichael J, Ponsford J, Gould KR, Tiego J, Forbes MK, Kotov R, Fornito A, and Spitz G
- Abstract
Psychopathology, including depression, anxiety, and post-traumatic stress, is a significant yet inadequately addressed feature of moderate-severe traumatic brain injury (TBI). Progress in understanding and treating post-TBI psychopathology may be hindered by limitations associated with conventional diagnostic approaches, specifically the Diagnostic and Statistical Manual of Mental Disorders (DSM) and International Classification of Diseases (ICD) . The Hierarchical Taxonomy of Psychopathology (HiTOP) offers a promising, transdiagnostic alternative to psychiatric classification that may more effectively capture the experiences of individuals with TBI. However, HiTOP lacks validation in the TBI population. To address this gap, we administered a comprehensive questionnaire battery, including 56 scales assessing homogeneous symptom components and maladaptive traits within HiTOP, to 410 individuals with moderate-severe TBI. We evaluated the reliability and unidimensionality of each scale and revised those with psychometric problems. Using a top-down, exploratory latent variable approach (bass-ackwards modeling), we subsequently constructed a hierarchical model of psychopathological dimensions tailored to TBI. The results showed that, relative to norms, participants with moderate-severe TBI experienced greater problems in the established HiTOP internalizing and detachment spectra, but fewer problems with thought disorder and antagonism. Fourteen of the 56 scales demonstrated psychometric problems, which often appeared reflective of the TBI experience and associated disability. The Hierarchical Taxonomy of Psychopathology Following Traumatic Brain Injury (HiTOP-TBI) model encompassed broad internalizing and externalizing spectra, splitting into seven narrower dimensions: Detachment , Dysregulated Negative Emotionality , Somatic Symptoms , Compensatory and Phobic Reactions , Self-Harm and Psychoticism , Rigid Constraint , and Harmful Substance Use . This study presents the most comprehensive empirical classification of psychopathology after TBI to date. It introduces a novel, TBI-specific transdiagnostic questionnaire battery and model, which addresses the limitations of conventional DSM and ICD diagnoses. The empirical structure of psychopathology after TBI largely aligned with the established HiTOP model (e.g., a detachment spectrum). However, these constructs need to be interpreted in relation to the unique experiences associated with TBI (e.g., considering the injury's impact on the person's social functioning). By overcoming the limitations of conventional diagnostic approaches, the HiTOP-TBI model has the potential to accelerate our understanding of the causes, correlates, consequences, and treatment of psychopathology after TBI.
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- 2024
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48. Associations between polygenic risk scores for cardiometabolic phenotypes and adolescent depression and body dissatisfaction.
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Ekberg KM, Michelini G, Schneider KL, Docherty AR, Shabalin AA, Perlman G, Kotov R, Klein DN, and Waszczuk MA
- Abstract
Background: Adolescents with elevated body mass index (BMI) are at an increased risk for depression and body dissatisfaction. Type 2 diabetes (T2D) is an established risk factor for depression. However, shared genetic risk between cardiometabolic conditions and mental health outcomes remains understudied in youth., Methods: The current study examined associations between polygenic risk scores (PRS) for BMI and T2D, and symptoms of depression and body dissatisfaction, in a sample of 827 community adolescents (M
age = 13.63, SDage = 1.01; 76% girls). BMI, depressive symptoms, and body dissatisfaction were assessed using validated self-report questionnaires., Results: BMI-PRS was associated with phenotypic BMI (β = 0.24, p < 0.001) and body dissatisfaction (β = 0.17, p < 0.001), but not with depressive symptoms. The association between BMI-PRS and body dissatisfaction was significantly mediated by BMI (indirect effect = 0.10, CI [0.07-0.13]). T2D-PRS was not associated with depression or body dissatisfaction., Conclusions: The results suggest phenotypic BMI may largely explain the association between genetic risk for elevated BMI and body dissatisfaction in adolescents. Further research on age-specific genetic effects is needed, as summary statistics from adult discovery samples may have limited utility in youth., Impact: The association between genetic risk for elevated BMI and body dissatisfaction in adolescents may be largely explained by phenotypic BMI, indicating a potential pathway through which genetic predisposition influences body image perception. Furthermore, age-specific genetic research is needed to understand the unique influences on health outcomes during adolescence. By identifying BMI as a potential mediator in the association between genetic risk for elevated BMI and body dissatisfaction, the current findings offer insights that could inform interventions targeting body image concerns and mental health in this population., (© 2024. The Author(s), under exclusive licence to the International Pediatric Research Foundation, Inc.)- Published
- 2024
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49. Incidence of Dementia Before Age 65 Years Among World Trade Center Attack Responders.
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Clouston SAP, Mann FD, Meliker J, Kuan PF, Kotov R, Richmond LL, Babalola T, Kritikos M, Yang Y, Carr MA, and Luft BJ
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- Humans, Male, Female, Incidence, Middle Aged, Prospective Studies, Occupational Exposure adverse effects, Occupational Exposure statistics & numerical data, New York City epidemiology, Adult, Rescue Work statistics & numerical data, Personal Protective Equipment statistics & numerical data, September 11 Terrorist Attacks, Dementia epidemiology, Emergency Responders statistics & numerical data
- Abstract
Importance: Reports suggest that the individuals who served in rescue operations following the terrorist attacks on the World Trade Center (WTC) have poorer brain health than expected., Objective: To assess the incidence of dementia before age 65 years in a prospective study of WTC responders and to compare incidence among responders with severe exposures to debris vs responders not exposed to building debris or who wore personalized protective equipment (PPE)., Design, Setting, and Participants: This prospective cohort study was conducted from November 1, 2014, to January 1, 2023, in an academic medical monitoring program available to verified WTC responders residing on Long Island, New York. Responders 60 years of age or younger without dementia at the time of their first cognitive assessment were followed up every 18 months, on average, for up to 5 years., Exposures: Exposure severity was based on responses to a detailed questionnaire of WTC exposures and exposure-related activities that included exposures to fine particulate dust and potentially neurotoxic debris, duration of work, and the use of PPE. Exposure level was divided into 5 categories ranging from low to severe., Main Outcomes and Measures: Incidence of all-cause dementia before age 65 years was the primary outcome. Dementia was diagnosed following standard guidelines relying on repeated measures of cognition., Results: Of 9891 responders, 5010 were eligible for inclusion in this study of cognitive function (median [IQR] age, 53 [48-57] years; 4573 [91.3%] male). There were 228 cases of dementia identified during 15 913.1 person-years of follow-up. Increasing WTC exposure severity was associated with incremental increases in the incidence rate of dementia per 1000 person-years (low, 2.95 [95% CI, 1.07-11.18]; mild, 12.16 [95% CI, 10.09-14.79]; moderate, 16.53 [95% CI, 13.30-20.81]; high, 30.09 [95% CI, 21.35-43.79]; and severe, 42.37 [95% CI, 24.86-78.24]). Adjusting for social, demographic, and relevant medical factors, each unit increase in exposure severity was associated with increased incidence of dementia (adjusted hazard ratio, 1.42 [95% CI, 1.18-1.71]; P < .001; mean risk difference, 9.74 [95% CI, 2.94-32.32] per 1000 person-years; P < .001)., Conclusions and Relevance: In this cohort study of WTC responders who survived these unique exposures and participated in a longitudinal follow-up study of cognition from 2014 through 2022, when compared with responders with the lowest exposure levels or responders who used PPE, more severe exposure to dust or debris was significantly associated with a higher risk of dementia before 65 years of age. This study suggests that the reliable use of PPE might help prevent the onset of dementia before age 65 years among individuals exposed to an uncontrolled building collapse. Future research is warranted to determine cerebral biomarkers for individuals with exposure-associated dementia.
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- 2024
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50. Long-Term Course of Remission and Recovery in Psychotic Disorders.
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Tramazzo S, Lian W, Ajnakina O, Carlson G, Bromet E, Kotov R, and Jonas K
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- Humans, Female, Male, Adult, Follow-Up Studies, Prognosis, Middle Aged, Young Adult, Disease Progression, Psychotic Disorders psychology, Schizophrenia therapy, Remission Induction
- Abstract
Objective: Understanding prognosis is critical to anticipating public health needs and providing care to individuals with psychotic disorders. However, the long-term course of remission and recovery remains unclear. In this study, the most common trajectories of illness course are described for a cohort of individuals followed for 25 years since first admission for psychosis., Methods: Participants are from the Suffolk County Mental Health Project, an epidemiological study of first-admission psychosis. Data for the present study was collected from six follow-ups, with 311 individuals assessed at the 25-year follow-up. Common patterns of remission and recovery were assessed in the baseline cohort of 591 individuals and the subsample from the 25-year follow up., Results: In the baseline cohort and the 25-year subsample, the most common trajectory for individuals with schizophrenia spectrum disorders was no remission and no recovery. Among individuals with other psychotic disorders, in both the baseline and 25-year cohorts, the modal pattern was one of intermittent remission and recovery. Individuals with other psychotic disorders were more likely to experience stable remission (15.1%) and stable recovery (21.1%), outcomes that were rare among individuals with schizophrenia spectrum disorders (0% and 0.6%, respectively)., Conclusions: The modal longitudinal pattern for individuals with other psychoses is one of multiple transitions into and out of symptomatic and functional recovery. Engagement in a long-term health care plan may help individuals detect and respond to these changes. Sustained remission and recovery are rare among people with schizophrenia spectrum disorders. Efforts should be directed toward developing more effective treatments for this population., Competing Interests: Dr. Jonas has served as a consultant for Allia Health. The other authors report no financial relationships with commercial interests.
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- 2024
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