Search

Your search keyword '"Koss, Leopold G."' showing total 223 results
Start Over Author "Koss, Leopold G." Language english
223 results on '"Koss, Leopold G."'

23. Tenascin Expression in Intraepithelial Neoplasia and Invasive Carcinoma of the Uterine Cervix

Author

Iskaros, Basem F. and Koss, Leopold G.

Subjects
Diagnosis, Epithelial tumors -- Diagnosis, Cervical cancer -- Diagnosis
Abstract

Tenascin (TN) is a large glycoprotein of the extracellular matrix that is transiently expressed in various tissues during embryogenesis and growth. It is also expressed in wound healing and tumor [...], * Objective.--To determine whether the expression of the matrix protein tenascin (TN) is of diagnostic or prognostic value in cervical intraepithelial neoplasia (CIN). Design.--Tenascin expression was evaluated in 75 formalin-fixed, paraffin-embedded biopsy and surgical specimens of the uterine cervix. Specimens included 15 low-grade squamous neoplastic lesions (CIN I), 30 high-grade squamous neoplastic lesions (CIN II and CIN III), 5 microinvasive carcinomas, and 15 invasive squamous carcinomas. Five normal cervices and 5 examples of cervicitis were used as controls. Expression of TN was studied by immunohistochemistry with a monoclonal mouse anti-human tenascin antibody. Tenascin expression in the basement membrane and in the stroma was arbitrarily graded as normal or slightly, moderately, or markedly increased. Results.--In the normal cervix, TN formed a thin band along the basement membrane of the squamous epithelium, except for the transformation zone, where the bands splintered and delicate TN fibers were present in the adjacent stroma. In cervicitis, TN bands were splintered in the basement membrane and the protein was weakly expressed in the stroma infiltrated by inflammatory cells. In the 45 CIN lesions, regardless of grade, the TN bands in the basement membrane were slightly (25 cases) or moderately (20 cases) increased. In CIN lesions with chronic stromal inflammation, a slight increase in stromal staining was observed, similar to the findings in cervicitis. In microinvasive and frankly invasive squamous cell carcinomas, TN expression was markedly increased in the basement membrane and in the stroma surrounding the invasive nests of cancer cells. Conclusion.--Tenascin expression may be of value in the assessment of early stromal invasion in cancer of the uterine cervix. Tenascin expression is of no value in distinguishing various grades of CIN and, therefore, is not a predictor of future behavior. (Arch Pathol Lab Med. 2000;124:1282-1286)

Published
2000

33. Testing in cervicovaginal cytology

Author

Koss, Leopold G.

Subjects
Cytology -- Testing, Pathological laboratories -- Standards, Medical tests -- Evaluation, Medical tests -- Standards
Published
2006

41. The Papanicolaou Test for Cervical Cancer Detection.

Author

Koss, Leopold G.

Subjects
*CERVICAL cancer diagnosis, *PAP test
Abstract

Reports on the detection system leading to discovery and treatment of precancerous lesions and early cancer of the uterine cervix. Screening and interpretation of cervical (Papanicolaou) smears; Failure of cytologic case finding; Other weak points of the system.

Published
1989
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results