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258 results on '"Komai, Yoshinobu"'

1. A phase II randomized trial of metastasis-directed therapy with alpha emitter radium-223 in men with oligometastatic castration-resistant prostate cancer (MEDAL)

Author

Yoshida, Soichiro, Takahara, Taro, Arita, Yuki, Ito, Masaya, Hayakawa, Sara, Oguchi, Tomohiko, Komai, Yoshinobu, Numao, Noboru, Yuasa, Takeshi, Inoue, Masaharu, Ushijima, Hiroki, Kudo, Shigehiro, Shimano, Yasumasa, Nakamura, Yuki, Uchida, Yusuke, Uehara, Sho, Tanaka, Hajime, Yaegashi, Hiroshi, Izumi, Kouji, Yokoyama, Minato, Matsuoka, Yoh, Yoshioka, Yasuo, Konishi, Koji, Nakanishi, Katsuyuki, Nagahara, Akira, Hirakawa, Akihiro, Koike, Ryuji, Koga, Fumitaka, Nishimura, Kazuo, Mizokami, Atsushi, Yonese, Junji, Kageyama, Yukio, Yoshimura, Ryoichi, and Fujii, Yasuhisa

Published
2023
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10. Renal function outcome after selective bladder-preserving tetramodality therapy consisting of maximal transurethral resection, induction chemoradiotherapy and consolidative partial cystectomy in comparison with radical cystectomy for patients with muscle-invasive bladder cancer: a two-centre retrospective study

Author

Fujiwara, Motohiro, Yokoyama, Minato, Toide, Masahiro, Fujiwara, Ryo, Tanaka, Hajime, Oguchi, Tomohiko, Komai, Yoshinobu, Yoshida, Soichiro, Matsuoka, Yoh, Numao, Noboru, Yamamoto, Shinya, Fukui, Iwao, Yonese, Junji, and Fujii, Yasuhisa

Published
2023
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11. Development of a New Two-Arm Transurethral Surgical System for En Bloc Resection of Bladder Tumor: A Preclinical Study.

Author

Komai, Yoshinobu, Nakajima, Kunihiko, Saito, Kyosuke, Tomioka, Yutaka, Masuda, Hitoshi, Ogawa, Akira, Yonese, Junji, Kobayashi, Etsuko, and Ito, Masaaki

Subjects
*BLADDER cancer, *KONJAK, *CLINICAL trials, *FORCEPS, *TRANSURETHRAL prostatectomy, TUMOR surgery
Abstract

Backgrounds and Objectives: To overcome the piecemeal nature of bladder tumor resection, en bloc resection of bladder tumor (ERBT) has been introduced. ERBT is difficult for surgeons to perform using the currently available system because it has only one arm. Herein, we aimed to develop a new transurethral surgical system to facilitate two-arm ERBT and to report the results of preclinical experiments using tumor phantoms. Methods: Initially, we aimed to develop a brand-new surgical system for ERBT but, after trial and error, we redirected our development to the creation of three elements: the left arm to grasp the tumor; the right arm to cut the tumor; and the system to operate the arms that can be attached to the existing surgical system (UES-40 SurgMaster® [Olympus Co. Ltd., Tokyo, Japan]). The current system was evaluated by performing simulated ERBTs using tumor phantoms made from konjac jelly. Results: Following the assembly of developed arms into the UES-40 SurgMaster, we conducted preliminary ERBTs. After performing several resections, we adopted a basket-shaped forceps as the left arm instead of grasping forceps and an arched electrode as the right arm. The two arms and single endoscope were placed in an equilateral triangle. We performed ERBT for the tumor phantoms that ranged from 0.5 to 2.0 cm without major redo. Conclusion: Herein, we introduced our development for two-arm ERBT. The current concept of "two-hand transurethral surgery" has the potential to be developed in future in vivo and clinical trials. [ABSTRACT FROM AUTHOR]

Published
2023
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12. Geriatric Nutritional Risk Index as a Predictor of Prognosis in Metastatic Renal Cell Carcinoma Treated with Nivolumab.

Author

Fujiwara, Ryo, Yuasa, Takeshi, Yamamoto, Shinya, Fujiwara, Motohiro, Takemura, Kosuke, Urasaki, Tetsuya, Oki, Ryosuke, Komai, Yoshinobu, Oguchi, Tomohiko, Numao, Noboru, and Yonese, Junji

Subjects
RENAL cell carcinoma, NUTRITIONAL assessment, RESEARCH methodology evaluation, RESEARCH methodology, METASTASIS, RETROSPECTIVE studies, GERIATRIC nutrition, NIVOLUMAB, RESEARCH funding, DESCRIPTIVE statistics, KARNOFSKY Performance Status, PREDICTIVE validity, OVERALL survival, EVALUATION
Abstract

The Geriatric Nutritional Risk Index (GNRI) has been reported as a screening tool to assess the nutrition-related risk with mortality in older patients and those with the various diseases. However, the prognostic value of GNRI in metastatic renal cell carcinoma (mRCC) patients receiving nivolumab therapy remains unclear. Fifty-six consecutive patients with mRCC receiving nivolumab between September 2013 and August 2020 at our institution were retrospectively analyzed. The survival outcomes and prognostic factors associated with overall survival (OS) were statistically analyzed. Thirteen and forty-three patients were classified with low (GNRI < 92) and high (GNRI ≥ 92) GNRI, respectively. Patients with low GNRI demonstrated significantly shorter OS (P = 0.0002) than those with high GNRI. In multivariate analysis, GNRI at the time of nivolumab (P = 0.008) was extracted as the predictor for OS in addition to Karnofsky performance status (KPS) (P = 0.016). Integration of the GNRI into the International Metastatic Renal Cell Cancer Database Consortium (IMDC) risk classification improved the c-index from 0.761 to 0.833 (combination of GNRI with IMDC risk classification) and to 0.778 (substitution of GNRI with KPS in IMDC risk classification). GNRI was a significant prognostic biomarker in mRCC patients receiving nivolumab. [ABSTRACT FROM AUTHOR]

Published
2023
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13. IMPACT OF ELEVATED URINARY METANEPHRINE/NORMETANEPHRINE AND IMPAIRED GLUCOSE TOLERANCE TEST ON THE DEVELOPMENT OF HYPOGLYCEMIA FOLLOWING REMOVAL OF PHEOCHROMOCYTOMA: MP12-05

Author

Waseda, Yuma, Moriyama, Shingo, Nakayama, Takayuki, Tanaka, Hajime, Inoue, Masaharu, Ito, Masaya, Komai, Yoshinobu, Yoshida, Soichiro, Kawamura, Naoko, Yokoyama, Minato, Ishioka, Junichiro, Matsuoka, Yoh, Numao, Noboru, Saito, Kazutaka, Fujii, Yasuhisa, and Kihara, Kazunori

Published
2016
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20. Doppler ultrasonography as a screening test for the detection of asymptomatic renal artery pseudoaneurysms following partial nephrectomy: A 15‐year single‐institution experience.

Author

Hamada, Kosuke, Komai, Yoshinobu, Fujiwara, Ryo, Numao, Noboru, Yamamoto, Shinya, and Yonese, Junji

Subjects
*NEPHRECTOMY, *DOPPLER ultrasonography, *RENAL artery, *MEDICAL screening, *FALSE aneurysms, *INFORMED consent (Medical law), *VENOUS thrombosis
Abstract

The pseudoaneurysm in Case 4 was confirmed to have regressed spontaneously by CECT at 4 months after surgery. gl As shown in Figure 1a, DUS as a screening test identified four cases of asymptomatic RAP. Abbreviations and Acronyms CECT contrast-enhanced computed tomography DUS Doppler ultrasonography DVT deep venous thrombosis PN partial nephrectomy POD postoperative day RAP renal artery pseudoaneurysm Where technically feasible, partial nephrectomy (PN) is increasingly considered the gold standard for localized renal cell carcinomas. Doppler ultrasonography as a screening test for the detection of asymptomatic renal artery pseudoaneurysms following partial nephrectomy: A 15-year single-institution experience. [Extracted from the article]

Published
2023
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21. Tumor shrinkage patterns of nivolumab monotherapy in metastatic renal cell carcinoma.

Author

Hamada, Kosuke, Fujiwara, Ryo, Takemura, Kosuke, Komai, Yoshinobu, Oguchi, Tomohiko, Numao, Noboru, Yamamoto, Shinya, Yonese, Junji, and Yuasa, Takeshi

Subjects
NIVOLUMAB, METASTASIS, LYMPH nodes
Abstract

Objectives: To investigate the tumor shrinkage patterns of patients with metastatic renal cell carcinoma treated with nivolumab monotherapy. Methods: Forty‐four consecutive patients with metastatic renal cell carcinoma treated with nivolumab monotherapy (81 metastatic and four primary lesions) between September 2013 and December 2020 were retrospectively analyzed. The tumor shrinkage rate of individual visceral and lymph node metastatic lesions and the primary site lesions treated with nivolumab monotherapy, as well as the association between overall survival and pretreatment tumor size, were statistically assessed. Results: Pretreatment tumor size for the total and individual target lesions, which included kidneys, lungs, pancreas, and lymph nodes, were not correlated with tumor shrinkage rate. The tumor shrinkage rate was found to have no significant association with pretreatment tumor size between any organ. In addition, there is no significant difference in tumor shrinkage rate between larger (>median value) and smaller (

Published
2022
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27. Robotic‐assisted laparoscopic surgery for synchronous primary rectal and prostate cancer: Initial case series.

Author

Fukata, Koji, Akiyoshi, Takashi, Numao, Noboru, Komai, Yoshinobu, Mukai, Toshiki, Hiyoshi, Yukiharu, Yamaguchi, Tomohiro, Nagasaki, Toshiya, Konishi, Tsuyoshi, and Fukunaga, Yosuke

Subjects
ABDOMINOPERINEAL resection, RECTAL cancer, LAPAROSCOPIC surgery, PROSTATE cancer, BLOOD loss estimation, RADICAL prostatectomy
Abstract

Few studies have reported the simultaneous resection of synchronous rectal and prostate cancers. Here, we report five patients undergoing simultaneous robotic‐assisted laparoscopic surgery (RALS) for synchronous rectal and prostate cancer. Rectal cancer operative procedures were high anterior (n =1), intersphincteric (n =2), or abdominoperineal (n =2) resection, followed by radical prostatectomy with vesico‐urethral anastomosis. There were no conversions to open surgery, with R0 resection achieved for all rectal cancer cases. The median operative time was 629 (range, 431–764) minutes, and the median estimated blood loss was 100 (range, 20–345) mL. There was one case of colorectal anastomotic leakage requiring covering ileostomy, and two cases of vesico‐urethral anastomotic leakage requiring Foley catheter reinsertion. Ileostomies were finally closed in all patients. Pad‐free or safety‐pad usage for post‐surgical urinary incontinence at 6 and 12 months was 3/5 and 5/5, respectively. Simultaneous RALS for synchronous rectal and prostate cancer may offer a safe and feasible approach in selected patients. [ABSTRACT FROM AUTHOR]

Published
2022
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29. Improving Accuracy, Reliability, and Efficiency of the RENAL Nephrometry Score With 3D Reconstructed Virtual Imaging.

Author

Yoshitomi, Kasumi Kaneko, Komai, Yoshinobu, Yamamoto, Tatsuya, Fukagawa, Eri, Hamada, Kosuke, Yoneoka, Yusuke, Fujiwara, Motohiro, Fujiwara, Ryo, Oguchi, Tomohiko, Numao, Noboru, Yuasa, Takeshi, Yamamoto, Shinya, Fukui, Iwao, and Yonese, Junji

Subjects
*NEPHRECTOMY, *RENAL cell carcinoma, *COMPUTED tomography, *KIDNEY tumors, *KIDNEY surgery, *THREE-dimensional imaging, *KIDNEYS, *RETROSPECTIVE studies, TUMOR surgery, RESEARCH evaluation
Abstract

Objective: To clarify the diagnostic performance of the three-dimensional reconstructed virtual image (3D-RVI) in evaluating RENAL nephrometry score (RENAL-NS).Methods: This study included 130 patients who underwent preoperative contrast-enhanced computed tomography followed by partial nephrectomy for renal tumors suggestive of renal cell carcinoma. RENAL-NS was calculated prior to the surgery, and tumor resection was performed referring to the score. We retrospectively reviewed preoperative contrast-enhanced computed tomography images. We calculated the inter-observer variability of RENAL-NS using 3D-RVI vs two-dimensional (2D) imaging and compared the ability of RENAL-NS using 3D-RVI vs 2D imaging to predict the risk of opening of the urinary collecting system. We also compared the two modalities for the time required to evaluate RENAL-NS.Results: RENAL-NS evaluated using 3D-RVI showed a higher inter-observer agreement compared to 2D-imaging (rs = 0.85 vs rs = 0.65). The "nearness to sinus" score was more strongly associated with the opening of the urinary collecting system when evaluated using 3D-RVI than 2D-imaging (AUC = 0.71 vs AUC = 0.57, P = .016). RENAL-NS using 2D-imaging required a significantly longer time compared to 3D-RVI (P = .036).Conclusion: Using 3D-RVI improves the accuracy, reliability and efficiency of RENAL-NS evaluation in preoperative assessment and can play an important role in preoperative assessment and intraoperative navigation. [ABSTRACT FROM AUTHOR]

Published
2022
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