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967 results on '"Klein, Sabine"'

12. Interferon-induced IL-10 drives systemic T-cell dysfunction during chronic liver injury

Author

Hackstein, Carl-Philipp, Spitzer, Jasper, Symeonidis, Konstantinos, Horvatic, Helena, Bedke, Tanja, Steglich, Babett, Klein, Sabine, Assmus, Lisa M., Odainic, Alexandru, Szlapa, Jennifer, Kessler, Nina, Beyer, Marc, Schmithausen, Ricarda, Latz, Eicke, Flavell, Richard A., Garbi, Natalio, Kurts, Christian, Kümmerer, Beate M., Trebicka, Jonel, Roers, Axel, Huber, Samuel, Schmidt, Susanne V., Knolle, Percy A., and Abdullah, Zeinab

Published
2023
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19. A methodological checklist for fMRI drug cue reactivity studies: development and expert consensus

Author

Ekhtiari, Hamed, Zare-Bidoky, Mehran, Sangchooli, Arshiya, Janes, Amy C., Kaufman, Marc J., Oliver, Jason A., Prisciandaro, James J., Wüstenberg, Torsten, Anton, Raymond F., Bach, Patrick, Baldacchino, Alex, Beck, Anne, Bjork, James M., Brewer, Judson, Childress, Anna Rose, Claus, Eric D., Courtney, Kelly E., Ebrahimi, Mohsen, Filbey, Francesca M., Ghahremani, Dara G., Azbari, Peyman Ghobadi, Goldstein, Rita Z., Goudriaan, Anna E., Grodin, Erica N., Hamilton, J. Paul, Hanlon, Colleen A., Hassani-Abharian, Peyman, Heinz, Andreas, Joseph, Jane E., Kiefer, Falk, Zonoozi, Arash Khojasteh, Kober, Hedy, Kuplicki, Rayus, Li, Qiang, London, Edythe D., McClernon, Joseph, Noori, Hamid R., Owens, Max M., Paulus, Martin P., Perini, Irene, Potenza, Marc, Potvin, Stéphane, Ray, Lara, Schacht, Joseph P., Seo, Dongju, Sinha, Rajita, Smolka, Michael N., Spanagel, Rainer, Steele, Vaughn R., Stein, Elliot A., Steins-Loeber, Sabine, Tapert, Susan F., Verdejo-Garcia, Antonio, Vollstädt-Klein, Sabine, Wetherill, Reagan R., Wilson, Stephen J., Witkiewitz, Katie, Yuan, Kai, Zhang, Xiaochu, and Zilverstand, Anna

Published
2022
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21. The clinical course of comorbid substance use disorder and attention deficit/hyperactivity disorder: protocol and clinical characteristics of the INCAS study

Author

Brynte, Christoffer, Aeschlimann, Myriam, Barta, Csaba, Begeman, Alex Hendikus Abraham, Bäcker, Amanda, Crunelle, Cleo Lina, Daigre, Constanza, De Fuentes-Merillas, Laura, Demetrovics, Zsolt, Dom, Geert, López, Lara Grau, Icick, Romain, Johnson, Brian, Joostens, Peter, Kapitány-Fövény, Máté, Karsinti, Emily, Kiefer, Falk, Konstenius, Maija, Levin, Frances R., Luderer, Mathias, Markus, Wiebren, Matthys, Frieda, Moggi, Franz, Palma-Alvarez, Raul Felipe, Paraskevopoulou, Maria, Ramos-Quiroga, J. Antoni, Schellekens, Arnt, Soravia, Leila M., Therribout, Norman, Thomas, Anil, van de Glind, Geurt, van Kernebeek, Michiel Willem, Vollstädt-Klein, Sabine, Vorspan, Florence, van den Brink, Wim, and Franck, Johan

Published
2022
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29. International Consensus Statement for the Screening, Diagnosis, and Treatment of Adolescents with Concurrent Attention-Deficit/Hyperactivity Disorder and Substance Use Disorder

Author

Özgen, Heval, Spijkerman, Renske, Noack, Moritz, Holtmann, Martin, Schellekens, Arnt S.A., van de Glind, Geurt, Banaschewski, Tobias, Barta, Csaba, Begeman, Alex, Casas, Miguel, Crunelle, Cleo L., Blanco, Constanza Daigre, Dalsgaard, Søren, Demetrovics, Zsolt, den Boer, Jacomine, Dom, Geert, Eapen, Valsamma, Faraone, Stephen V., Franck, Johan, González, Rafael A., Grau-López, Lara, Groenman, Annabeth P., Hemphälä, Malin, Icick, Romain, Johnson, Brian, Kaess, Michael, Kapitány-Fövény, Máté, Kasinathan, John G., Kaye, Sharlene S., Kiefer, Falk, Konstenius, Maija, Levin, Frances R., Luderer, Mathias, Martinotti, Giovanni, Matthys, Frieda I.A., Meszaros, Gergely, Moggi, Franz, Munasur-Naidoo, Ashmita P., Post, Marianne, Rabinovitz, Sharon, Ramos-Quiroga, Antoni, Sala, Regina, Shafi, Abu, Slobodin, Ortal, Staal, Wouter G., Thomasius, Rainer, Truter, Ilse, van Kernebeek, Michiel W., Velez-Pastrana, Maria C., Vollstädt-Klein, Sabine, Vorspan, Florence, Young, Jesse T., Yule, Amy, van den Brink, Wim, and Hendriks, Vincent

Published
2020

37. Terlipressin therapy is associated with increased risk of colonisation with multidrug‐resistant bacteria in patients with decompensated cirrhosis.

Author

Mücke, Marcus M., Hernández‐Tejero, María, Gu, Wenyi, Kuhn, Michael, Janz, Malte, Keller, Marisa I., Fullam, Anthony, Altepeter, Laura, Mücke, Victoria T., Finkelmeier, Fabian, Schwarzkopf, Katharina M., Cremonese, Carla, Hunyady, Peter‐Merton, Heilani, Myriam W., Uschner, Frank Erhard, Schierwagen, Robert, Brol, Maximilian J., Fischer, Julia, Klein, Sabine, and Peiffer, Kai‐Henrik

Subjects
PROPENSITY score matching, MULTIDRUG resistance, GENE silencing, MULTIDRUG-resistant tuberculosis, CIRRHOSIS of the liver, MULTIDRUG resistance in bacteria, LIVER failure
Abstract

Summary: Background: Patients with cirrhosis are susceptible to develop bacterial infections that trigger acute decompensation (AD) and acute‐on‐chronic liver failure (ACLF). Infections with multidrug‐resistant organisms (MDRO) are associated with deleterious outcome. MDRO colonisation frequently proceeds MDRO infections and antibiotic therapy has been associated with MDRO colonisation. Aim: The aim of the study was to assess the influence of non‐antibiotic medication contributing to MDRO colonisation. Methods: Three hundred twenty‐four patients with AD and ACLF admitted to the ICU of Frankfurt University Hospital with MDRO screening were included. Regression models were performed to identify drugs associated with MDRO colonisation. Another cohort (n = 129) from Barcelona was included to validate. A third multi‐centre cohort (n = 203) with metagenomic sequencing data of stool was included to detect antibiotic resistance genes. Results: A total of 97 patients (30%) were identified to have MDRO colonisation and 35 of them (11%) developed MDRO infection. Patients with MDRO colonisation had significantly higher risk of MDRO infection than those without (p = 0.0098). Apart from antibiotic therapy (odds ratio (OR) 2.91, 95%‐confidence interval (CI) 1.82–4.93, p < 0.0001), terlipressin therapy in the previous 14 days was the only independent covariate associated with MDRO colonisation in both cohorts, the overall (OR 9.47, 95%‐CI 2.96–30.23, p < 0.0001) and after propensity score matching (OR 5.30, 95%‐CI 1.22–23.03, p = 0.011). In the second cohort, prior terlipressin therapy was a risk factor for MDRO colonisation (OR 2.49, 95% CI 0.911–6.823, p = 0.075) and associated with risk of MDRO infection during follow‐up (p = 0.017). The validation cohort demonstrated that antibiotic inactivation genes were significantly associated with terlipressin administration (p = 0.001). Conclusions: Our study reports an increased risk of MDRO colonisation in patients with AD or ACLF, who recently received terlipressin therapy, while other commonly prescribed non‐antibiotic co‐medications had negligible influence. Future prospective trials are needed to confirm these results. [ABSTRACT FROM AUTHOR]

Published
2024
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50. The Role of Hypoxia-Inducible Factor 1 Alpha in Acute-on-Chronic Liver Failure.

Author

Mücke, Marcus M., El Bali, Nihad, Schwarzkopf, Katharina M., Uschner, Frank Erhard, Kraus, Nico, Eberle, Larissa, Mücke, Victoria Therese, Bein, Julia, Beyer, Sandra, Wild, Peter J., Schierwagen, Robert, Klein, Sabine, Zeuzem, Stefan, Welsch, Christoph, Trebicka, Jonel, and Brieger, Angela

Subjects
LIVER failure, GENE expression, IMMUNOSTAINING, HYPOXIA-inducible factor 1, NF-kappa B, WESTERN immunoblotting
Abstract

Acute-on-chronic liver failure (ACLF) is associated with increased mortality. Specific therapy options are limited. Hypoxia-inducible factor 1 alpha (HIF-1α) has been linked to the pathogenesis of chronic liver disease (CLD), but the role of HIF-1α in ACLF is poorly understood. In the current study, different etiologies of CLD and precipitating events triggering ACLF were used in four rodent models. HIF-1α expression and the intracellular pathway of HIF-1α induction were investigated using real-time quantitative PCR. The results were verified by Western blotting and immunohistochemistry for extrahepatic HIF-1α expression using transcriptome analysis. Exploratory immunohistochemical staining was performed to assess HIF-1α in human liver tissue. Intrahepatic HIF-1α expression was significantly increased in all animals with ACLF, regardless of the underlying etiology of CLD or the precipitating event. The induction of HIF-1α was accompanied by the increased mRNA expression of NFkB1 and STAT3 and resulted in a marked elevation of mRNA levels of its downstream genes. Extrahepatic HIF-1α expression was not elevated. In human liver tissue samples, HIF-1α expression was elevated in CLD and ACLF. Increased intrahepatic HIF-1α expression seems to play an important role in the pathogenesis of ACLF, and future studies are pending to investigate the role of therapeutic HIF inhibitors in ACLF. [ABSTRACT FROM AUTHOR]

Published
2024
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