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1. Management and outcome of cutaneous diphtheria in adolescent refugees in Germany, June 2022 – October 2023

Author

Zink, Alicia, Hofer, Juliana, Schneider, Christian, Kessler, Franziska, Klenze, Hannes, Klauwer, Dietrich, Maleki, Klaudia, Müller, Andreas, Goretzki, Sarah, Wang, Shubei, Kobbe, Robin, Ramirez, Andrea Vanegas, Bode, Sebastian, Janda, Ales, Fressle, Roland, Remppis, Jonathan, Henneke, Philipp, Rieg, Siegbert, Berger, Anja, Sing, Andreas, Hufnagel, Markus, and Spielberger, Benedikt D.

Published
2024
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3. A comparison of pediatric inflammatory multisystem syndrome temporarily-associated with SARS-CoV-2 and Kawasaki disease

Author

Hufnagel, Markus, Jakob, André, Doenhardt, Maren, Diffloth, Natalie, Schneider, Dominik T., Trotter, Andreas, Roessler, Martin, Schmitt, Jochen, Berner, Reinhard, Adamiak-Brych, Grazyna, Aderhold, Martina, Aggar, Sara, Ahmed, Mohammed-Ahmed, Akanbi, Sandra, Anders, Kristin, Arens, Stefan, Armann, Jakob, Baßmann, Christoph, Baumbach, Lisa, Bayrhof, Otto-Jonas, Beier, Gerald, Berger, Ardua, Bernard, Daniel, Berwald, Mario, Biering, Adina, Blümlein, Ulrike, Blume, Stefanie, Böckenholt, Kai, Bölke, Carsten, Boesing, Thomas, Bonacker, Robert, Borchers, Monika-Maria, Brenner, Britta, Brinkmann, Folke, Brühler, Jasmin, Brunner, Jürgen, Buchtala, Laura, Budde, Jörg, Bullmann, Reinhard, Schoppe, Marc Carré, Cvetanovic, Gordana, Czwienzek, Alina, Degirmenci, Metin, Dejas, Fenja, Demirdelen, Bergüzar, Diederichs, Anke, Dittrich, Maren, Döhring, Katharina, Donath, Helena, Ebert, Franziska, Eff, Annemarie, Ehrentraut, Kerstin, Eißler, Fiene, Eißner, Anne, Endres, Elisa, Engler, Matthias, Fiedler, Andreas, Fingerhut, Karin, Finster, Agnes, Fischer, Doris, Flümann, Simon, Foth, Svenja, Fremery, Christian, Frenzke, Holger, Galow, Lukas, Gappa, Monika, Gerling, Stephan, Gitzinger, Stina, Glaser, Nicola, Goj, Karoline, Goretzki, Sarah Christina, Gröger, Katrin, Groteclaes, Tim, Grüner, Judith, Grünwedel, Mike, Haag, Stephan, Hacker, Lisa, Halwas, Nikolaus, Hanke, Christof, Haupt, Anne, Heinrich, Christina, Heinrich, Julia, Hempel, Lutz, Hermann, Matthias, Herzog, Matthias, Heubner, Georg, Hillebrand, Georg, Himpel, Matthias, Hilker, Kai-Alexandra, Hittmeyer, Cara, Höche, Alexander, Höfgen, Mirjam, Höpner, Uwe, Holtkamp, Katharina, Hoppen, Thomas, Horstkemper, Marita, Horstmann, Judith, Hospach, Anton, Ido, Nora, Iliaev, Vladimir, Ioannou, Phryne, Jantzen, Dirk, Jenssen, Söhnke, Jung, Claudia, Kaiser-Labusch, Petra, Kalhoff, Herrmann, Keck, Johanna, Kelch, Felicitas, Keller, Thomas, Kelzon, Svetlana, Kern, Jan, Keßner, Marie-Sophie, Kever, Daniel, Kirchner, Arni, Kirschstein, Martin, Kitz, Richard, Klauwer, Dietrich, Kleff, Christine, Kluthe, Christof, Knechtel, Jan, Knop, Lisanne, Köster, Holger, Vasconcelos, Malte Kohns, Konrad, Florian, Kosteczka, Robert, Koukli, Georgia, Kowski, Sascha, Kuhnigk, Mirco, Kuska, Marion, Kwaschnowitz, Sachicko, Lange, Veit, Lautner, Gerrit, Libuschewski, Hanna, Liese, Johannes, Lindemann, Linus, Lorenz, Norbert, Lorenzen, Niko, Lubitz, Daniela, Machata, Heike, Mader, Franziska, Malath, Ingrid, Mampe, Cornelie, Markowsky, Andrea, Mauritz, Maximilian, Meister, Jochen, Menden, Melanie, Menzel, Felix, Merker, Michael, Meyer, Jens, Meyer-Dobkowitz, Lars, Mohorovicic, Marko, Moise, Laura Gabriela, Morawski, Yvonne, Motzkus, Laura, Müller, Bianca, Müller, Guido, Müller, Mirja, Müller, Meike, Niehaus, Thomas, Oberthür, Andre, Ohlendorf, Johanna, Olar, Florina, Opgen-Rhein, Bernd, Östreicher, Iris, Parthey, Kathlee, Pentek, Falk, Pötzsch, Simone, Ponsa, Corinna, Rambow, Jenny, Reck, Heike, Reichert, Friedrich, Reil, Annika, Reinhardt, Thomas, Richter, Carolin, Richter, Jost Wigand, Rieber, Nikolaus, Ringe, Hannelore, Rühlmann, Alexander, Samol, Anja, Sauerbrey, Kristin, Schäfer, Miriam, Schaeffer, Nico, Scheffler, Miriam, Schlick, Christian, Schmitt, Caroline, Schneider, Dominik, Schneider, Hans-Christoph, Schnelke, Alexander, Schrewe, Roland, Schrod, Lothar, Schroers, Oliver, Schütz, Katharina, Schulteß, Leonie, Schumacher, Isabel, Seidel, Sabrina, Simon, Arne, Soditt, Volker, Sönmez, Ezgi, Spancken, Elena, Spath, Lisa, Spinner, Sebastian, Stastny, Barbara, Steidl, Michael, Steif, Benedikt, Steimer, Ann-Kathrin, Stemberg, Frank, Stockmann, Antje, Stöhring, Thomas, Sumbadze, Daria, Teichmann, Axel, Thiel, Lion, Tränkner, Jan, Trau, Stefanie, Treichel, Tina, van den Heuvel, Alijda, Vehse, Kai, Vischer, Lena, Wahjudi, Tatjana, Waldecker, Karin, Walden, Ulrike, Warneke, Laura, Weber, Sarah, Wehl, Götz, Wehrhoff, Falk, Weigert, Alexander, Wenzel, Sandra, Werner, Annika, Weste, Clarissa, Wichmann, Barbara, Wild, Florian, Willmer, Denise, Wolf, Felicitas, Wrenger, Nina, Wurm, Donald, Yussif, Anne-Sophie, Zeißig, Yvonne, and Zügge, Ulrich

Subjects
Multidisciplinary, Medizin
Abstract

The connection between Pediatric Inflammatory Multisystem Syndrome (PIMS) and Kawasaki Disease (KD) is not yet fully understood. Using the same national registry, clinical features and outcome of children hospitalized in Germany, and Innsbruck (Austria) were compared. Reported to the registry were 395 PIMS and 69 KD hospitalized patients. Patient age in PIMS cases was higher than in KD cases (median 7 [IQR 4–11] vs. 3 [IQR 1–4] years). A majority of both PIMS and KD patients were male and without comorbidities. PIMS patients more frequently presented with organ dysfunction, with the gastrointestinal (80%), cardiovascular (74%), and respiratory (52%) systems being most commonly affected. By contrast, KD patients more often displayed dermatological (99% vs. 68%) and mucosal changes (94% vs. 64%), plus cervical lymph node swelling (51% vs. 34%). Intensive care admission (48% vs. 19%), pulmonary support (32% vs. 10%), and use of inotropes/vasodilators (28% vs. 3%) were higher among PIMS cases. No patients died. Upon patient discharge, potentially irreversible sequelae—mainly cardiovascular—were reported (7% PIMS vs. 12% KD). Despite differences in age distribution and disease severity, PIMS and KD cases shared many common clinical and prognostic characteristics. This supports the hypothesis that the two entities represent a syndrome continuum.

Published
2023

4. Contributors

Author

Acton, Robert D., Annich, Gail, Bercovitz, Rachel S., Betensky, Marisol, Brown, Ashley C., Cholette, Jill Marie, Downey, Laura A., Dunn, Amy L., Faraoni, David, Fasano, Ross, Fenger-Eriksen, Christian, Flanagan, Siobhan, Gehrie, Eric A., Goel, Ruchika, Goldenberg, Neil A., Goobie, Susan M., Guzzetta, Nina A., Haas, Thorsten, Haimed, Abraham, Hendrickson, Jeanne, Hunter, Samuel A., John, Mohan M., Josephson, Cassandra, Klauwer, Dietrich, Leeper, Christine M., Lieberman, Lani, Marchetto, Luca, Meeks, Shannon L., Nellenbach, Kimberly, Rodriguez, Vilmarie, Russell, Robert T., Scarlatescu, Ecaterina, Shashidharan, Subhadra, Sidonio, Robert F., Spinella, Philip C., Steiner, Marie Elizabeth, Stricker, Paul A., Thiagarajan, Ravi, Winkler, Anne M., Woods, Gary M., and Zerra, Patricia E.

Published
2024
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5. Prognostic value of troponin in infants with hypoplastic left heart syndrome between Stage I and II of palliation.

Author

Christmann, Martin, Valsangiacomo Büchel, Emanuela R., Dave, Hitendu, Klauwer, Dietrich, and Cavigelli-Brunner, Anna

Subjects
BIOMARKERS, CARDIAC surgery, HEART failure, LACTATES, MYOCARDIAL infarction, PALLIATIVE treatment, REOPERATION, SURVIVAL, RETROSPECTIVE studies, TROPONIN, HYPOPLASTIC left heart syndrome, PROGNOSIS
Abstract

Background : The period between stage I and II procedure for treatment of hypoplastic left heart syndrome (HLHS) bears high mortality and morbidity. Methods : We sought to analyze the prognostic value of Troponin T/I (Trop), a well-recognized marker for myocardial damage and heart failure, for predicting outcome in a retrospective analysis of 70 infants with HLHS at our institution between March 2001 and October 2014. Results : Stage I procedure consisted of Norwood I operation in 35 (50%) and Hybrid-approach in 22 (31%) patients. Palliative care was chosen for 13 (19%) patients. Trop values were collected from clinical charts and were analyzed in relation to the overall outcome. Trop was significantly higher after Norwood I operation in comparison to Hybrid-approach (median 7.1 µg/l (0.7-20.9), vs 1.2 µg/l (0.3-17.9), P < 0.001). Overall mortality of treated patients was 39% (22 patients). Survival was 54% (19 patients) after Norwood and 73% (16 patients) after Hybrid-approach. Independently from the procedure used, maximal Trop and initial lactate values were significantly higher in non-survivors than in survivors, with median Trop of 9 µg/l (0.6-18.8) vs. 3.4 μg/l (0.4-20.9), P 0.007, and median lactate of 3.7 mmol/L (1.6-25) vs. 2.9 mmol/L (0.3-14.6), p 0.03. Reinterventions were required in 17 (30%) patients, 4 (11%) after Norwood and 13 (59%) after Hybrid procedure. No correlation was found between the need for reintervention and Trop levels in the interstage period. Conclusions : Patients with HLHS have significantly higher Trop levels after Norwood procedure than after Hybrid-approach. Maximal Trop values were related to mortality, but did not correlate with the need for reinterventions. [ABSTRACT FROM AUTHOR]

Published
2018
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8. Pediatric heart transplantation.

Author

Schweiger M, Stiasny B, Dave H, Cavigelli-Brunner A, Balmer C, Kretschmar O, Bürki C, Klauwer D, and Hübler M

Abstract

Pediatric heart transplantation (pHTx) represents a small (14%) but very important and particular part in the field of cardiac transplantation. This treatment has lifelong impact on children. To achieve the best short and especially long-term survival with adequate quality of life, which is of crucial importance for this young patient population, one has to realize and understand the differences with adult HTx. Indication for transplantation, waitlist management including ABO incompatible (ABOi) transplantation and immunosuppression differ. Although young transplant recipients are ultimately likely to be considered for re-transplantation. One has to distinguish between myopathy and complex congenital heart disease (CHD). The differences in anatomy and physiology make the surgical procedure much more complex and create unique challenges. These recipients need a well-organized and educated team with pediatric cardiologists and intensivists, including a high skilled surgeon, which is dedicated to pHTx. Therefore, these types of transplants are best concentrated in specialized centers to achieve promising outcome.

Published
2015
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