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Your search keyword '"Kjetil Sørensen"' showing total 2 results
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1. Variability of activity patterns across mood disorders and time of day

Author

Karoline Krane-Gartiser, Arne E. Vaaler, Ole Bernt Fasmer, Kjetil Sørensen, Gunnar Morken, and Jan Scott

Subjects
Unipolar, Bipolar, Mixed states, Actigraphy, Motor activity, Time series, Psychiatry, RC435-571
Abstract

Abstract Background Few actigraphy studies in mood disorders have simultaneously included unipolar (UP) and bipolar (BD) depression or BD mixed states as a separate subgroup from mania. This study compared objectively measured activity in UP, BD depression, mania and mixed states and examined if patterns differed according to time of day and/or diagnostic group. Methods Eighty -eight acutely admitted inpatients with mood disorders (52 UP; 18 mania; 12 BD depression; 6 mixed states) underwent 24 hours of actigraphy monitoring. Non-parametric analyses were used to compare median activity level over 24 h (counts per minute), two time series (64-min periods of continuous motor activity) in the morning and evening, and variability in activity across and within groups. Results There was no between-group difference in 24-h median level of activity, but significant differences emerged between BD depression compared to mania in the active morning period, and between UP and mania and mixed states in the active evening period. Within-group analyses revealed that UP cases showed several significant changes between morning and evening activity, with fewer changes in the BD groups. Conclusions Mean activity over 24 hours has limited utility in differentiating UP and BD. In contrast, analysis of non-linear variability measures of activity at different times of day could help objectively distinguish between mood disorder subgroups. Trial registration ClinicalTrials.gov Identifier: NCT01415323 , first registration July 6, 2011.

Published
2017
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2. Increased circulating IL-18 levels in severe mental disorders indicate systemic inflammasome activation

Author

Thor Ueland, Erlend Bøen, Inge Joa, Ulrik Fredrik Malt, Pål Aukrust, Rune A. Kroken, Vidar M. Steen, Kirsten Wedervang-Resell, Ole A. Andreassen, Birgitte Boye, Tove Lekva, Srdjan Djurovic, Erik Johnsen, Torbjørn Elvsåshagen, Attila Szabo, Trine Vik Lagerberg, Dimitrios Andreou, John Abel Engh, Kjetil Sørensen, Lars T. Westlye, Ingrid Melle, Terje Nærland, Sigrun Hope, Ole Kristian Drange, Nils Eiel Steen, Margrethe Collier Høegh, Ingrid Agartz, Mashhood Ahmed Sheikh, Kevin S O' Connell, Gunnar Morken, and Melissa Auten Weibell

Subjects
Psychosis, Inflammasomes, psykisk helse, Immunology, Psykiatri, barnepsykiatri: 757 [VDP], Inflammation, VDP::Midical sciences: 700::Basic medical, dental and veterinary sciences: 710::Medical immunology: 716, VDP::Medisinske fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Medisinsk immunologi: 716, interleukin-18, Psychiatry, child psychiatry: 757 [VDP], 03 medical and health sciences, Behavioral Neuroscience, 0302 clinical medicine, schizofreni, NLRC4, inflammasjon, NLR Family, Pyrin Domain-Containing 3 Protein, mental disorders, medicine, VDP::Midical sciences: 700::Clinical medical sciences: 750::Psychiatry, child psychiatry: 757, Humans, Bipolar disorder, psykiatri, VDP::Medisinske fag: 700::Klinisk medisinske fag: 750::Psykiatri, barnepsykiatri: 757, 030304 developmental biology, 0303 health sciences, bipolar lidelse, Endocrine and Autonomic Systems, business.industry, Interleukin-18, Inflammasome, kolesterol, medicine.disease, 3. Good health, Psychotic Disorders, Schizophrenia, Interleukin 18, medicine.symptom, business, 030217 neurology & neurosurgery, Dyslipidemia, medicine.drug
Abstract

Background -Schizophrenia (SCZ) and bipolar disorder (BD) are severe mental illnesses (SMI) that are part of a psychosis continuum, and dysregulated innate immune responses have been suggested to be involved in their pathophysiology. However, disease-specific immune mechanisms in SMI are not known yet. Recently, dyslipidemia has been linked to systemic inflammasome activation, and elevated atherogenic lipid ratios have been shown to correlate with circulating levels of inflammatory biomarkers in SMI. It is, however, not yet known if increased systemic cholesterol load leads to inflammasome activation in these patients. Methods - We tested the hypothesis that patients with SCZ and BD display higher circulating levels compared to healthy individuals of key members of the IL-18 system using a large patient cohort (n = 1632; including 737 SCZ and 895 BD), and healthy controls (CTRL; n = 1070). In addition, we assessed associations with coronary artery disease risk factors in SMI, focusing on relevant inflammasome-related, neuroendocrine, and lipid markers. Results - We report higher baseline levels of circulating IL-18 system components (IL-18, IL-18BPA, IL-18R1), and increased expression of inflammasome-related genes (NLRP3 and NLRC4) in the blood of patients relative to CTRL. We demonstrate a cholesterol dyslipidemia pattern in psychotic disorders, and report correlations between levels of blood cholesterol types and the expression of inflammasome system elements in SMI. Conclusions - Based on these results, we suggest a role for inflammasome activation/dysregulation in SMI. Our findings further the understanding of possible underlying inflammatory mechanisms and may expose important therapeutic targets in SMI.

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