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288 results on '"Khorrami M"'

14. The Mid-Infrared Instrument for the James Webb Space Telescope , X: Operations and Data Reduction

Author

Gordon, Karl D., Chen, C. H., Anderson, Rachel E., Azzollini, Ruymán, Bergeron, L., Bouchet, Patrice, Bouwman, Jeroen, Cracraft, Misty, Fischer, Sebastian, Friedman, Scott D., García-Marín, Macarena, Glasse, Alistair, Glauser, Adrian M., Goodson, G. B., Greene, T. P., Hines, Dean C., Khorrami, M. A., Lahuis, Fred, Lajoie, C.-P., Meixner, M. E., Morrison, Jane E., O’Sullivan, Brian, Pontoppidan, K. M., Regan, M. W., Ressler, M. E., Rieke, G. H., Scheithauer, Silvia, Walker, Helen, and Wright, G. S.

Published
2015
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17. Different Strategies for Bio-Conjugation of Anti-CD4 Monoclonal Antibodies to Silica-Coated Magnetic Nanoparticles and Their Application for the Positive Selection of CD4+ Lymphocytes.

Author

Khorrami, M., Mahmoudi, M., Shobeiri, S. S., Moghadam, M., and Sankian, M.

Subjects
MONONUCLEAR leukocytes, MAGNETIC nanoparticles, MONOCLONAL antibodies, MAGNETICS, LYMPHOCYTES, T cells, CHO cell
Abstract

Efficient cell separation techniques are required for the isolation of various cellular populations in fundamental research. In the present study, five types of magnetic nanoparticles (MNPs) have been designed to isolate CD4+ T cells from peripheral blood mononuclear cells. MNPs were synthesized by a modified solvothermal method and subsequently coated by a silica shell through the sol-gel process. Then, the anti-CD4 antibody was conjugated on the surface of different groups of MNPs, which were functionalized with various cross-linkers (including the carboxylic and aldehyde groups) and proteins (such as protein A and streptavidin). The performance of prepared MNPs for the separation of CD4+ lymphocytes was investigated by optical microscopy and flow-cytometry. This study revealed that the cell isolation rates by different functionalized groups, including aldehyde, carboxyl, CHO-protein A, COOH-protein A, and streptavidin conjugated with nanoparticles, were 32 ± 3, 32 ± 1, 80 ± 4, 70 ± 1, and 71 ± 2%, respectively. Based on such data, the CHO-protein A-functionalized MNPs have been considered a practical choice to separate CD4+ T cells with over 92 ± 3% purity. MNPs obtained in the study provide an adequate tool for the cell isolation method and further present the dramatic potential to be applied to several fields of biomedical purpose. [ABSTRACT FROM AUTHOR]

Published
2023
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26. On the Connection Between Flap Side-Edge Noise and Tip Vortex Dynamics

Author

Casalino, D, Hazir, A, Fares, E, Duda, B, and Khorrami, M. R

Subjects
Aerodynamics, Acoustics
Abstract

The goal of the present work is to investigate how the dynamics of the vortical flow about the flap side edge of an aircraft determine the acoustic radiation. A validated lattice- Boltzmann CFD solution of the unsteady flow about a detailed business jet configuration in approach conditions is used for the present analysis. Evidence of the connection between the noise generated by several segments of the inboard flap tip and the aerodynamic forces acting on the same segments is given, proving that the noise generation mechanism has a spatially coherent and acoustically compact character on the scale of the flap chord, and that the edge-scattering effects are of secondary importance. Subsequently, evidence of the connection between the kinematics of the tip vortex system and the aerodynamic force is provided. The kinematics of the dual vortex system are investigated via a core detection technique. Emphasis is placed on the mutual induction effects between the two main vortices rolling up from the pressure and suction sides of the flap edge. A simple heuristic formula that relates the far-field noise spectrum and the cross-spectrum of the unsteady vortical positions is developed.

Published
2015

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