13 results on '"Kent, J.W."'
Search Results
2. Transcriptomics of cortical gray matter thickness decline during normal aging
- Author
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Kochunov, P., Charlesworth, J., Winkler, A., Hong, L.E., Nichols, T.E., Curran, J.E., Sprooten, E., Jahanshad, N., Thompson, P.M., Johnson, M.P., Kent, J.W., Jr., Landman, B.A., Mitchell, B., Cole, S.A., Dyer, T.D., Moses, E.K., Goring, H.H.H., Almasy, L., Duggirala, R., Olvera, R.L., Glahn, D.C., and Blangero, J.
- Published
- 2013
- Full Text
- View/download PDF
3. Association of TMTC2 with human nonsyndromic sensorineural hearing loss
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Runge, C.L., Indap, A., Zhou, Y., Kent, J.W., King, E., Erbe, C.B., Cole, R., Littrell, J., Merath, K., James, R., Rüschendorf, F., Kerschner, J.E., Marth, G., Hübner, N., Göring, H.H.H., Friedland, D.R., Kwok, W.M., and Olivier, M.
- Subjects
Cardiovascular and Metabolic Diseases ,otorhinolaryngologic diseases - Abstract
IMPORTANCE: Sensorineural hearing loss (SNHL) is commonly caused by conditions that affect cochlear structures or the auditory nerve, and the genes identified as causing SNHL to date only explain a fraction of the overall genetic risk for this debilitating disorder. It is likely that other genes and mutations also cause SNHL. OBJECTIVE: To identify a candidate gene that causes bilateral, symmetric, progressive SNHL in a large multigeneration family of Northern European descent. DESIGN, SETTING, AND PARTICIPANTS: In this prospective genotype and phenotype study performed from January 1, 2006, through April 1, 2016, a 6-generation family of Northern European descent with 19 individuals having reported early-onset hearing loss suggestive of an autosomal dominant inheritance were studied at a tertiary academic medical center. In addition, 179 unrelated adult individuals with SNHL and 186 adult individuals reporting nondeafness were examined. MAIN OUTCOMES AND MEASURES: Sensorineural hearing loss. RESULTS: Nine family members (5 women [55.6%]) provided clinical audiometric and medical records that documented hearing loss. The hearing loss is characterized as bilateral, symmetric, progressive SNHL that reached severe to profound loss in childhood. Audiometric configurations demonstrated a characteristic dip at 1000 to 2000 Hz. All affected family members wear hearing aids or have undergone cochlear implantation. Exome sequencing and linkage and association analyses identified a fully penetrant sequence variant (rs35725509) on chromosome 12q21 (logarithm of odds, 3.3) in the TMTC2 gene region that segregates with SNHL in this family. This gene explains the SNHL occurrence in this family. The variant is also associated with SNHL in a cohort of 363 unrelated individuals (179 patients with confirmed SNHL and 184 controls, P = 7 x 10-4). CONCLUSIONS AND RELEVANCE: A previously uncharacterized gene, TMTC2, has been identified as a candidate for causing progressive SNHL in humans. This finding identifies a novel locus that causes autosomal dominant SNHL and therefore a more detailed understanding of the genetic basis of SNHL. Because TMTC2 has not been previously reported to regulate auditory function, the discovery reveals a potentially new, uncharacterized mechanism of hearing loss.
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- 2016
4. Recent Advances in Genomics of Body Composition, Adipose Tissue Metabolism, and Its Relation to the Development of Obesity
- Author
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Nava-González, E.J., Gallegos-Cabriales, E.C., Lopez-Alvarenga, J.C., Kent, J.W., Jr., and Bastarrachea, R.A.
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- 2014
- Full Text
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5. Contributors
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Abbasi, S., Adolphi, N.L., Aikawa, E., Akbar, H., Akilesh, S., Aladjem, M.I., Allocca, M., Alpini, G., Alroy, J., Altman, B.J., Andujar, P., Antonello, Z.A., Antsiferova, M., Apica, B.S., Ariel, I., Aronow, B.J., Ashley, J.W., Badell, I.R., Bagg, A., Bajaj, M., Banerjee, S., Barbieri, J.S., Bardes, E.E., Barisoni, L., Barletta, J.A., Baskin, D.G., Bastarrachea, R.A., Bayat, A., Bayrak-Toydemir, P., Beck, A.H., Beebe, D.C., Beltran, H., Benichou, G., Bergman, M., Bernard, S.A., Bernardi, P., Best, D.H., Blair, H.C., Bonaldo, P., Bondy, J., Bosman, F.T., Bouma, B.E., Brandi, M.L., Bresler, S.C., Brewer, M.T., Britto, C.J., Brock, J.E., Brosens, L.A.A., Budge, H., Burd, E.M., Burness, M.L., Bushnell, T., Byrd, J., Calderone, A., Campbell, M.J., Cao, D., Capell, W., Cardigan, R., Carey, P.M., Carneiro, F., Carp, S.A., Carter, A.M., Cascio, M.J., Castellani, R.J., Castellanos, J., Caviglia, J.M., Cecconi, F., Chamarthy, S., Chamma, E., Chang, A., Chang, A.Y., Chang, N.C., Chapman, D.G., Charles, A.K., Chen, D., Chen, D.F., Chen, P., Cheng, J., Chernock, R.D., Cheruvu, S., Chiang, J., Childs, G.V., (formerly Gwen C. Moriarty), Cho, Y.-B., Choi, A.M.K., Choi, J.K., Cipriani, N.A., Cleary, J.O.S.H., Clementi, E., Clines, G.A., Cohen, M.L., Coleman, W.B., Coletta, D.K., Collie, A.M.B., Cooling, L., Coron, E., Côté, D., Coussens, L.M., Crielaard, B.J., Cron, R.Q., Crum, C.P., Cruz, N.M., Dairkee, S.H., Daly, C.A., Dang, C.V., Danila, M.I., Daradich, A., Darnell, C.M., Dartt, D.A., Das, A., D’Asta, F., DeFronzo, R., De Hertogh, G., Dela Cruz, C.S., de la Cruz-Merino, L., De Palma, C., Demetris, A.J., DeMorrow, S., Denechaud, P.-D., Di Carli, M.F., DiCarlo, E.F., Dikic, I., Dimberg, A., Dowell, M.L., Doyle, L.A., Drachenberg, C.B., Driskell, E., Duda, D.G., Duker, J., Dyck, J.R.B., Ecker, C., Elifritz, J.M., Elsheikh, T.M., Ensari, A., Ernst, L.M., Esch, K.J., Fajas-Coll, L., Fang, Q., Farhat, N.A., Farshid, G., Faye-Petersen, O.M., Fehlings, M.G., Fend, F., Feng, X., Fernandes, H., Fernandez-Checa, J.C., Ferreira, B.P., Fidler, I.J., Finn, J.A., Fischer, A., Fishbein, M.C., Fleit, H.B., Flomenbaum, M., Folkins, A., Francis, H., Frank, K.M., Frevert, C.W., Frias, A.E., Friedman, J.R., Fukumura, D., Furie, M.B., Gaffo, A.L., Galateau-Sallé, F., Gallegos-Cabriales, E.C., Gandhi, C.R., Gannon, M., García-Moliner, M.L., Gardner, J.M., Gasper, C.A., Gaulard, P., Gaut, J.P., Gavia-García, G., Gerrard, C., Ghosh, A.P., Giersch, A.B.S, Gilbert, S.R., Gill, J.R., Giusti, F., Glorioso, J.M., González-Torres, M.C., Goolsby, C.L., Gora, M.J., Gordon, I.O., Gotlieb, A.I., Gouw, A.M., Goyal, A., Grégoire, M., Graham, B.B., Granger, D.N., Greene, A.K., Greenlee, J.J., Griffiths, R., Guimarães, A.R., Gulati, M., Gullet, A., Gupta, S., Haider, N.B., Halushka, M.K., Hambuch, T.M., Hamza, S.M., Han, Y., Hansen, W.P., Hard, R., Harris, B.T., Harris, J.E., Hartnett, M.E., Hasserjian, R.P., Hatch, G.M., Hefti, M.M., Heller, D.S., Hemminger, J.A., Hendrickson, J.E., Henley, K.D., Herzog, E., Hess, J.R., Hill, C.E., Hipp, J., Hobbs, R., Höller, D., Hodges, R.R., Homer, R.J., Horowitz, N., Hsi, E.D., Hsieh, A.L., Hunt, J.M., Hure, S., Husain, A.N., Hussey, S., Hutcheson, J.D., Hutson, R.M., Illescas-Vacas, A., Irvin, C.G., Jaffer, F.A., Jäger, R., Jain, R.K., Jain, S., James, J., Jansen, M., Jarzembowski, J.A., Jaurand, M.-C., Jean, D., Jegga, A.G., Jellinger, K.A., Jen, K.-Y., Jo, V.Y., Johnson, B., Jones, R.L., Kalfa, T.A., Kamionek, M., Kang, D., Kantari, C., Kantor, P.F., Kanzaki, G., Karns, R., Katzman, P.J., Kawai, T., Kelley, T.W., Kent, J.W., Jr, Kerr, E.H., Kew, R.R., Khalighi, M., Khanh Vu, T.H., Khong, T.Y., Kim, B.S., Kim, J., Klein, M.J., Knechtle, S.J., Konkle, B.A., Kowalewska, J., Kricka, L.J., Krishnan, B., Kumar, A., Kumar, S., Kvietys, P., Kwong, R.Y., Lafont, E., Laga, A.C., Lagarrigue, S., Lakin, A., Laszik, Z.G., Lauwers, G.Y., Laver, N.V., Lawlor, M.W., Lederer, J.A., Lee, R.E., Lee, W.M., LeGallo, R., Leich, E., Lemmens, B., Le Pimpec-Barthes, F., Leval, L., Levy, B.D., Lewis, J.S., Jr, Lewis, T.L., Leyva-Illades, D., Li, L., Li, Y.-P., Lianidou, E.S., Liao, L., Liapis, H., Lin, J.B., Lin, A.-L., Lindsay, M.E., Liu, E., Longacre, T., Lopez-Alvarenga, J.C., Lopez-Mejía, I., Lozanski, G., Lucia, M.S., Luk, E., Lutty, G.A., Maclellan, R.A., Madabhushi, A., Mahindra, A., Malek, E., Mammucari, C., Mani, H., Mao, S.A., Marboe, C.C., Marí, M., Marini, F., Markou, A., Marshall, A.H., Martin, S.J., Marzioni, M., Masli, S., Matsukuma, K.E., Matulonis, U.A., Mayfield, J., McCoy, J.P., Jr., McDougle, C.J., McGinnis, M.R., McGuire, A., McKinstry, K.K., McManus, B.M., Means, A.L., Meny, G.M., Merchant, N., Meserve, E.E.K, Mess, A.M., Minervini, M.I., Mitchell, R.N., Monaco, S.E., Monga, S.P., Monica Way, H.-Y., Montecucco, C., Montone, K.T., Morgan, E.A., Morgan, T.K., Morrissey, K., Mortensen, R.M., Moser, S.A., Mosquera, J.M., Mossman, B.T., Motta, A.C.F., Mullins, E., Murphy, G.F., Murray, L., Mysorekar, I.U., Nadel, B., Nadon, A.S., Nagathihalli, N., Nájera-Medina, O., Nalesnik, M.A., Nast, C.C., Natkunam, Y., Nault, J.C., Nava-González, E.J., Nayar, R., Nerenz, R.D., Neumann, H., Ni, H., Nolte, K.B., Norton, L., Nowak, J., Nucera, C., Nyberg, S.L., Oakes, S.A., Offerhaus, G.J.A., Ojha, S., Okabe, H., Oliveira, A.M., Osborn, E.A., O'Tierney-Ginn, P., Ott, G., Ozcan, A., Padera, R.F., Pagano, M.B., Page, E.K., Paintal, A.S., Pairon, J.-C., Papadimitriou, J.C., Park, H.-J., Park, J.Y., Parsons, L.N., Patra, D., Peclovits, A., Peeters, P.M., Perkins, T.N., Perry, G., Perumbeti, A., Petersen, C.A., Petrache, I., Petroff, M.G., Pettus, J.R., Picken, M.M., Pierson, C.R., Pittman, M.E., Pogoriler, J., Politi, K., Pollack, S.M., Quintanilla-Martínez, L., Rai, M.F., Ramkissoon, S., Randhawa, P.S., Rangel, J.R., Rasola, A., Reeves, B., Reheman, A., Remick, D.G., Reynaert, N.L., Richmond, J.M., Rivella, S., Rivenbark, A.G., Rizzuto, R., Roberts, K.A., Robin, D.A., Robinson, L.J., Rockey, D.C., Rosenwald, A., Rossetto, O., Roth, K.A., Roy-Chowdhury, J., Roy-Chowdhury, N., Rubin, M.A., Rudnicki, M.A., Russell, D.S., Ryter, S.W., Saban, D.R., Sacher, R.A., Sacks, D.B., Sagaert, X., Sagdeo, A., Sahay, B., Sahin, A., Samali, A., Sampson, B., Sánchez-Escribano, R., Sandri, M., Sanyal, A., Sasatomi, E., Sauer, V., Scherpereel, A., Schmidt, E.P., Schwabe, R.F., Scorrano, L., Scott, M.G., Scull, J.C., Seidman, M.A., Seki, A., Sellati, T.J., Serban, K., Serhan, C.N., Seshan, S.V., Seth, A., Seykora, J.T., Sharma, N., Shi, C., Shi, S.-R., Shimada, M., Shimizu, A., Singer, D.B., Sitko, K., Smallwood, R.F., Smiraglia, D.J., Smith, B.R., Smola, H., Soubeyrand, M., Stahl, W.L., Stajić, M., Stanworth, S.J., Stathatos, N., Stemler, K.M., Stevens, T.M., Stine, Z.E., Stoll, M.L., Strati, A., Strutt, T.M., Sund, M., Sung, M.M., Symonds, M.E., Tabar, S., Takahashi, N., Talmadge, J.E., Tang, V., Tangrea, M., Tarango, C., Tario, J.D., Jr, Taylor, C.R., Taylor, R., Tearney, G.J., Tefera, K., Thomas, S., Thornburg, K.L., Tirado, C.A., Tobian, A.A.R., Tomaszewski, J.E., Tormey, C.A., Torres, R., Tran, M.-H., Tredget, E.E., Treister, N.S., Trotter, J., Troyer, D., Truong, L., Tubbs, R.R., Turakhia, S., Unglert, C.I., Utheim, T., Vahabzadeh, A., van Bokhoven, A., Vanden Berghe, T., Vandenabeele, P., van der Klei, I.J., Vanguri, V.K., Van Noorden, C.J.F, Van Poznak, C., Vassallo, R.R., Vawda, R., Vieth, M., Visscher, D.W., Volk, S.W., Vyas, G.N., Waggoner, S.N., Walczak, H., Walker, D.H., Wallace, P.K., Wanat, K.A., Wang, J., Wang, Y., Wang, Y.X., Warger, W.C., II, Wei, S., Weinman, S.A., Wenig, B.M., Wentz, S.C., Werner, S., Wertheim, G., Whitley, E.M., Wooderchak-Donahue, W., Woods, K., Wouters, E.F.M., Wu, Y., Xing, W., Yachimski, P., Yan, P., Yang, J., Yang, L., Yoshizawa, S., Yuan, J., Yun, S.-H., Yvon, A., Zhang, H., Zhang, P., Zhao, Z., Zhu, G., Zhu, R., Zordoky, B.N., Zou, J., Zuccato, J.A., and Zucman-Rossi, J.
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- 2014
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6. GWAS of self-reported osteoarthritis in Mexican Americans from the San Antonio Family Study
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Havill, L.M., Coan, H.B., Dyer, T.D., Kent, J.W., Jr., Choudary, A., Nicolella, D.P., Carless, M.A., Kumar, S., Almeida, M.A., Duggirala, R., Glahn, D.C., Mahaney, M.C., Blangero, J., and Curran, J.E.
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- 2013
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7. Variation in osteoarthritis biomarker serum comp levels in Mexican Americans is associated with SNPs in a region of chromosome 22q encompassing MICAL3, BCL2L13, and BID
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Coan, H.B., Curran, J.E., Dyer, T.D., Kent, J.W., Jr., Choudary, A., Nicolella, D.P., Carless, M.A., Kumar, S., Almeida, M.A., Duggirala, R., Glahn, D.C., Mahaney, M.C., Blangero, J., and Havill, L.M.
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- 2013
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8. QTL-based association analyses reveal novel genes influencing pleiotropy of metabolic syndrome (MetS).
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Zhang, Y., Kent, J.W., Olivier, M., Ali, O., Broeckel, U., Abdou, R.M., Dyer, T.D., Comuzzie, A., Curran, J.E., Carless, M.A., Rainwater, D.L., Göring, H.H.H., Blangero, J., and Kissebah, A.H.
- Subjects
METABOLIC syndrome ,GENETIC pleiotropy ,TYPE 2 diabetes ,SINGLE nucleotide polymorphisms ,CARDIOVASCULAR diseases - Abstract
Objective: Metabolic Syndrome (MetS) is a phenotype cluster predisposing to type 2 diabetes and cardiovascular disease. We conducted a study to elucidate the genetic basis underlying linkage signals for multiple representative traits of MetS that we had previously identified at two significant QTLs on chromosomes 3q27 and 17p12. Design and Methods: We performed QTL-specific genomic and transcriptomic analyses in 1,137 individuals from 85 extended families that contributed to the original linkage. We tested in SOLAR association of MetS phenotypes with QTL-specific haplotype-tagging SNPs as well as transcriptional profiles of peripheral blood mononuclear cells (PBMCs). Results: SNPs significantly associated with MetS phenotypes under the prior hypothesis of linkage mapped to seven genes at 3q27 and seven at 17p12. Prioritization based on biologic relevance, SNP association, and expression analyses identified two genes: insulin-like growth factor 2 mRNA-binding protein 2 ( IGF2BP2) at 3q27 and tumor necrosis factor receptor 13B ( TNFRSF13B) at 17p12. Prioritized genes could influence cell-cell adhesion and adipocyte differentiation, insulin/glucose responsiveness, cytokine effectiveness, plasma lipid levels, and lipoprotein densities. Conclusions: Using an approach combining genomic, transcriptomic, and bioinformatic data we identified novel candidate genes for MetS. [ABSTRACT FROM AUTHOR]
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- 2013
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9. Rotation technique in electron microscopy of viruses
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Agrawal, O., Kent, J.W., and MacKay, D.M.
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electron microscopy ,parasitology ,taxonomie ,Laboratory of Virology ,parasitologie ,Laboratorium voor Virologie ,histology ,histologie ,taxonomy ,virussen ,cytology ,viruses ,elektronenmicroscopie ,cytologie - Published
- 1965
10. Renal dysfunction is more likely in recipients bridged to heart transplantation with inotropes than with left ventricular assist devices: an analysis of pre-transplant characteristics in the modern era
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Drakos, S.G, Gilbert, E.M, Moore, S.A, Stringham, J.C, Hammond, E.H, Long, J.W, Fuller, T.C, Kent, J.W, Bull, D.A, Schmitz, S.S, Hagan, M.E, Campbell, B.A, Folsom, J.W, Stamos, L.A, Horne, B.D, and Renlund, D.G
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- 2004
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11. Application of statistical techniques to the analysis of fungal populations
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Kent, J.W.
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- 1972
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12. Critical analysis of fungi in two sand-dune soils
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Dickinson, C.H. and Kent, J.W.
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- 1972
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13. Reviews: Books.
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Kent, J.W.
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- BIOLOGY & Industry (Book)
- Abstract
Reviews the book `Biology and Industry: Practical Biotechnology for A-Level,' by I. Olejnik and B. Farmer.
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- 1990
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