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2. Pharmacogenetic and clinical risk factors for bevacizumab-related gastrointestinal hemorrhage in prostate cancer patients treated on CALGB 90401 (Alliance)

Author

Patel, Jai N., Jiang, Chen, Owzar, Kouros, Hertz, Daniel L., Wang, Janey, Mulkey, Flora A., Kelly, William K., Halabi, Susan, Furukawa, Yoichi, Lassiter, Cameron, Dorsey, Susan G., Friedman, Paula N., Small, Eric J., Carducci, Michael A., Kelley, Michael J., Nakamura, Yusuke, Kubo, Michiaki, Ratain, Mark J., Morris, Michael J., and McLeod, Howard L.

Published
2024
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6. Outcomes of Bruton tyrosine kinase inhibitors for chronic lymphocytic leukaemia in US veterans with severe renal dysfunction.

Author

Lin, Chenyu, Anderson, Clare E., Scobie, Micaela R., Rodgers, Thomas D., Kelley, Michael J., and Friedman, Daphne R.

Subjects
BRUTON tyrosine kinase, LYMPHOCYTIC leukemia, OLDER patients, PROTEIN-tyrosine kinase inhibitors, CHRONIC kidney failure, KIDNEY diseases, HEART failure
Abstract

The article published in the British Journal of Haematology explores the outcomes of Bruton tyrosine kinase inhibitors (BTKi) for chronic lymphocytic leukaemia (CLL) in US veterans with severe renal dysfunction. The study found that BTK inhibitors are a viable treatment option for patients with severe renal impairment, including those on haemodialysis, without significantly increasing cardiovascular or infectious complications. However, patients with severe renal failure on BTK inhibitors had poorer survival, potentially due to renal failure as an adverse risk rather than a suboptimal response to BTK inhibition. Dose reductions of BTK inhibitors may improve tolerability in this population without compromising efficacy. [Extracted from the article]

Published
2024
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20. Understanding Russian Disinformation and How the Joint Force Can Address It.

Author

Kelley, Michael J.

Subjects
*DISINFORMATION, *INFORMATION warfare, *WAR, *SCHOLARLY method
Abstract

Russia will dominate information warfare if the United States does not treat disinformation as central to Russian strategy. This article examines the vital role disinformation played in post-Cold War Russian strategy, including its strategy in the current Russia-Ukraine War, and in a departure from previous scholarship, this article observes that US defense leaders are aware of Russian disinformation but have failed to assess its impact or sufficiently negate Russian influence. The article also reviews current US efforts and suggests proactive ways to counter Russia's disinformation strategy. [ABSTRACT FROM AUTHOR]

Published
2024
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21. Researcher Experience and Comfort With Telemedicine and Remote Patient Monitoring in Cancer Treatment Trials.

Author

Lichtenstein, Morgan R L, Levit, Laura A, Schenkel, Caroline, Kirkwood, Kelsey, Fashoyin-Aje, Lola A, Bruinooge, Suanna S, Kelley, Michael J, Mailman, Josh A, Magnuson, Allison, Mirda, Daniel P, Natesan, Divya, and Hershman, Dawn L

Subjects
TUMOR treatment, RESEARCH funding, CLINICAL medicine research, DESCRIPTIVE statistics, TELEMEDICINE, EXPERIENCE, PATIENT monitoring, HUMAN comfort, COMPARATIVE studies, COVID-19 pandemic
Abstract

Background Since the onset of COVID-19, oncology practices across the US have integrated telemedicine (TM) and remote patient monitoring (RPM) into routine care and clinical trials. The extent of provider experience and comfort with TM/RPM in treatment trials, however, is unknown. We surveyed oncology researchers to assess experience and comfort with TM/RPM. Methods Between April 10 and June 1, 2022, we distributed email surveys to US-based members of the American Society of Clinical Oncology (ASCO) whose member records indicated interest or specialization in clinical research. We collected respondent demographic data, clinical trial experience, workplace characteristics, and comfort and experience with TM/RPM use across trial components in phase I and phase II/III trials. TM/RPM was defined as clinical trial-related healthcare and monitoring for patients geographically separated from trial site. Results There were 141 surveys analyzed (5.1% response rate). Ninety percent of respondents had been Principal Investigators, 98% practiced in a norural site. Most respondents had enrolled patients in phase I (82%) and phase II/III trials (99%). Across all phases and trial components, there was a higher frequency of researcher comfort compared to experience. Regarding remote care in treatment trials, 75% reported using TM, RPM, or both. Among these individuals, 62% had never provided remote care to trial patients before the pandemic. Conclusion COVID-19 spurred the rise of TM/RPM in cancer treatment trials, and some TM/RPM use continues in this context. Among oncology researchers, higher levels of comfort compared with real-world experience with TM/RPM reveal opportunities for expanding TM/RPM policies and guidelines in oncology research. [ABSTRACT FROM AUTHOR]

Published
2024
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29. PMS2CL interference leading to erroneous identification of a pathogenic PMS2 variant in Black patients

Author

Verma, Anurag, Verma, Shefali S., Bradford, Yuki, Brock, Ashlei, DerOhannessian, Stephanie, Dudek, Scott, Dunn, Joseph, Drivas, Theodore, Haubein, Ned, Hu-Sain, Khadijah, Judy, Renae, Kloter, Ashley, Ko, Yi-An, Livingstone, Meghan, Morrel, Linda, Morse, Colleen, Poindexter, Afiya, Risman, Marjorie, Tran, Teo, Vadivieso, Fred, Weaver, JoEllen, Rader, Daniel J., Ritchie, Marylyn D., Feldman, Michael D., Beechert, Christina, Forsythe, Caitlin, Fuller, Erin D., Gu, Zhenhua, Lattari, Michael, Lopez, Alexander, Overton, John D., Padilla, Maria Sotiropoulos, Pradhan, Manasi, Manoochehri, Kia, Schleicher, Thomas D., Widom, Louis, Wolf, Sarah E., Ulloa, Ricardo H., Averitt, Amelia, Banerjee, Nilanjana, Cantor, Michael, Li, Dadong, Malhotra, Sameer, Sharma, Deepika, Staples, Jeffrey, Bai, Xiaodong, Balasubramanian, Suganthi, Bao, Suying, Boutkov, Boris, Chen, Siying, Eom, Gisu, Habegger, Lukas, Hawes, Alicia, Khalid, Shareef, Krasheninina, Olga, Lanche, Rouel, Mansfield, Adam J., Maxwell, Evan K., Mitra, George, Nafde, Mona, O’Keeffe, Sean, Orelus, Max, Panea, Razvan, Polanco, Tommy, Rasool, Ayesha, Reid, Jeffrey G., Salerno, William, Staples, Jeffrey C., Sun, Kathie, Abecasis, Goncalo, Backman, Joshua, Damask, Amy, Dobbyn, Lee, Ferreira, Manuel Allen Revez, Ghosh, Arkopravo, Gillies, Christopher, Gurski, Lauren, Jorgenson, Eric, Kang, Hyun Min, Kessler, Michael, Kosmicki, Jack, Li, Alexander, Lin, Nan, Liu, Daren, Locke, Adam, Marchini, Jonathan, Marcketta, Anthony, Mbatchou, Joelle, Moscati, Arden, Paulding, Charles, Sidore, Carlo, Stahl, Eli, Watanabe, Kyoko, Ye, Bin, Zhang, Blair, Ziyatdinov, Andrey, Ayer, Ariane, Guvenek, Aysegul, Hindy, George, Coppola, Giovanni, Freudenberg, Jan, Bovijn, Jonas, Siminovitch, Katherine, Praveen, Kavita, Lotta, Luca A., Kapoor, Manav, Haas, Mary, Riaz, Moeen, Verweij, Niek, Sosina, Olukayode, Akbari, Parsa, Nakka, Priyanka, Gelfman, Sahar, Gokhale, Sujit, De, Tanima, Rajagopal, Veera, Shuldiner, Alan, Tzoneva, Gannie, Rodriguez-Flores, Juan, Chen, Esteban, Jones, Marcus B., LeBlanc, Michelle G., Mighty, Jason, Mitnaul, Lyndon J., Nishtala, Nirupama, Rana, Nadia, Hernandez, Jaimee, Baras, Aris, Deubler, Andrew, Economides, Aris, Cappadocia, Jacqueline, Aiello, Lisa B., Kelley, Michael J., Katona, Bryson W., and Maxwell, Kara N.

Published
2024
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30. Tumor Necrosis Factor Receptor Family Member RANK Mediates Osteoclast Differentiation and Activation Induced by Osteoprotegerin Ligand

Author

Hsu, Hailing, Lacey, David L., Dunstan, Colin R., Solovyev, Irina, Colombero, Anne, Timms, Emma, Tan, Hong-Lin, Elliott, Gary, Kelley, Michael J., Sarosi, Ildiko, Wang, Ling, Xia, Xing-Zhong, Elliott, Robin, Chiu, Laura, Black, Tabitha, Scully, Sheila, Capparelli, Casey, Morony, Sean, Shimamoto, Grant, Bass, Michael B., and Boyle, William J.

Published
1999

31. Precision Medicine for CRC Patients in the Veteran Population: State-of-the-Art, Challenges and Research Directions

Author

Mohapatra, Shyam S., Batra, Surinder K., Bharadwaj, Srinivas, Bouvet, Michael, Cosman, Bard, Goel, Ajay, Jogunoori, Wilma, Kelley, Michael J., Mishra, Lopa, Mishra, Bibhuti, Mohapatra, Subhra, Patel, Bhaumik, Pisegna, Joseph R., Raufman, Jean-Pierre, Rao, Shuyun, Roy, Hemant, Scheuner, Maren, Singh, Satish, Vidyarthi, Gitanjali, and White, Jon

Published
2018
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38. On-Site Nurse-Led Cancer Genetics Program Increases Cancer Genetic Testing Completion in Black Veterans.

Author

Shevach, Jeffrey W., Aiello, Lisa B., Lynch, Julie A., Petersen, Jeffrey, Hoffman-Hogg, Lori, Hartzfeld, Deborah, Lundquist, Margaret, Kelley, Michael J., Scheuner, Maren T., Montgomery, Robert, Damjanov, Nevena, Robinson, Kyle, Yu-Ning Wong, Jhala, Darshana, Parikh, Ravi B., and Maxwell, Kara N.

Subjects
TUMOR genetics, STATISTICS, OCCUPATIONAL roles, HEALTH services accessibility, EVALUATION of human services programs, SCIENTIFIC observation, GENETIC mutation, CONFIDENCE intervals, MULTIVARIATE analysis, RESEARCH methodology, GENETIC testing, RETROSPECTIVE studies, REGRESSION analysis, GERM cells, MANN Whitney U Test, FISHER exact test, COMPARATIVE studies, T-test (Statistics), PEARSON correlation (Statistics), NURSES, DESCRIPTIVE statistics, CHI-squared test, RESEARCH funding, VETERANS, ODDS ratio, LONGITUDINAL method
Abstract

PURPOSE Telegenetics services can expand access to guideline-recommended cancer genetic testing. However, access is often not distributed equitably to all races and ethnicities. We evaluated the impact of an on-site nurse-led cancer genetics service in a diverse Veterans Affairs Medical Center (VAMC) oncology clinic on likelihood of germline testing (GT) completion. METHODS We conducted an observational retrospective cohort study of patients who were referred for cancer genetics services at the Philadelphia VAMC between October 1, 2020, and February 28, 2022. We evaluated the association between genetics service (on-site v telegenetics) and likelihood of GT completion in a subcohort of new consults, excluding patients with prior consults and those referred for known history of germline mutations. RESULTS A total of 238 Veterans, including 108 (45%) seen on site, were identified for cancer genetics services during the study period,with themajority referred for a personal (65%) or family (26%) history of cancer. In the subcohort of new consults, 121 Veterans (54% self-identified race/ethnicity [SIRE]-Black), including 60 (50%) seen on site, were included in the analysis of germline genetic testing completion. In a univariate analysis, patients who were seen by the on-site genetics service had 3.2-fold higher likelihood of completing GT (relative risk, 3.22; 95% CI, 1.89 to 5.48) compared with the telegenetics service. In multivariable regression analysis, the on-site genetics service was associated with higher likelihood of GT completion, but this association was only statistically significant in SIRE-Black compared with SIRE-White Veterans (adjusted RR, 4.78; 95% CI, 1.53 to 14.96; P < .001; P-interaction of race Ã--genetics service = .016). CONCLUSION An on-site nurse-led cancer genetics service embedded in a VAMC Oncology practice was associated with higher likelihood of germline genetic testing completion than a telegenetics service among self-identified Black Veterans. [ABSTRACT FROM AUTHOR]

Published
2023
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42. Implementation of Lung Cancer Screening in the Veterans Health Administration

Author

Kinsinger, Linda S., Anderson, Charles, Kim, Jane, Larson, Martha, Chan, Stephanie H., King, Heather A., Rice, Kathryn L., Slatore, Christopher G., Tanner, Nichole T., Pittman, Kathleen, Monte, Robert J., McNeil, Rebecca B., Grubber, Janet M., Kelley, Michael J., Provenzale, Dawn, Datta, Santanu K., Sperber, Nina S., Barnes, Lottie K., Abbott, David H., Sims, Kellie J., Whitley, Richard L., Wu, R. Ryanne, and Jackson, George L.

Published
2017
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43. Actionable Genomic Alterations in Prostate Cancer Among Black and White United States Veterans.

Author

Valle, Luca F, Nickols, Nicholas G, Hausler, Ryan, Alba, Patrick R, Anglin-Foote, Tori, Perez, Cristina, Yamoah, Kosj, Rose, Brent S, Kelley, Michael J, DuVall, Scott L, Garraway, Isla P, Maxwell, Kara N, and Lynch, Julie A

Subjects
AMERICAN veterans, SEQUENCE analysis, GENETIC variation, RETROSPECTIVE studies, METASTASIS, RACE, CANCER patients, DESCRIPTIVE statistics, WHITE people, PROSTATE tumors, AFRICAN Americans, GENETIC profile
Abstract

Black Veterans have higher a incidence of localized and metastatic prostate cancer compared to White Veterans yet are underrepresented in reports of frequencies of somatic and germline alterations. This retrospective analysis of somatic and putative germline alterations was conducted in a large cohort of Veterans with prostate cancer (N = 835 Black, 1613 White) who underwent next generation sequencing through the VA Precision Oncology Program, which facilitates molecular testing for Veterans with metastatic cancer. No differences were observed in gene alterations for FDA approved targetable therapies (13.5% in Black Veterans vs. 15.5% in White Veterans, P =.21), nor in any potentially actionable alterations (25.5% vs. 28.7%, P =.1). Black Veterans had higher rates of BRAF (5.5% vs. 2.6%, P <.001) alterations, White Veterans TMPRSS2 fusions (27.2% vs. 11.7%, P <.0001). Putative germline alteration rates were higher in White Veterans (12.0% vs. 6.1%, P <.0001). Racial disparities in outcome are unlikely attributable to acquired somatic alterations in actionable pathways. [ABSTRACT FROM AUTHOR]

Published
2023
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44. Analysis of furnace contamination on superconducting radio frequency niobium using secondary-ion mass spectrometry.

Author

Angle, Jonathan W., Lechner, Eric M., Reece, Charles E., Stevie, Fred A., and Kelley, Michael J.

Subjects
RADIO frequency, MASS spectrometry, FURNACES, NIOBIUM, SURFACE contamination, ATOMIC absorption spectroscopy, SECONDARY ion mass spectrometry
Abstract

Detection of surface contamination on niobium materials used in superconducting radio frequency (SRF) applications is difficult due to quantitative sensitivity and near-atomic depth resolution needed. Inspection of samples known to have experienced surface contamination was found to have inconsistent nitride coverage after high-temperature nitrogen gas exposure ("doping"). We compare contaminating species found on samples treated in several different vacuum furnaces, both "exposed" directly in the chamber and "protected" by containment shielding from evaporative sources with "furnace caps." Typically, furnace caps are used to impede contamination from reaching the interior surface of cavities during the high-temperature vacuum bake that immediately precedes exposure to nitrogen gas. Although, to date, little is known about the effectiveness of these caps, SIMS results showed that they were effective in limiting contamination arising from the furnace environment. Inspection of sample surfaces by SEM showed a lack of nitrides present on contaminated specimens. TEM with energy dispersive spectroscopy performed on these samples revealed that a carbon-rich layer now existed, indicating that a relatively high contaminant load prevents the nucleation and growth of surface nitrides, while thus inhibiting interstitial nitrogen uptake. Except in extreme cases, subsequent removal of the top several micrometers of the surface via electropolishing appears to effectively eliminate any strong influence on the subsequent SRF cavity performance. With the absence of furnace cleaning, carbon contamination was found to be nearly 10× higher for protected nitrogen-doped and electropolished samples, with minimal metallic contamination detected for both processes. SIMS analysis was also performed to compare the cleanliness of samples fully prepared by such nitrogen "doping" with those prepared by a related process, involving the dissolution of niobium surface oxide and diffusion of oxygen into the surface. This oxygen doping or alloying process offers attractive advantages. [ABSTRACT FROM AUTHOR]

Published
2023
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45. Veterans Health Administration National TeleOncology Service.

Author

Zullig, Leah L., Raska, Whitney, McWhirter, Gina, Sherman, Scott E., Makarov, Danil, Becker, Daniel, King, Heather A., Pura, John, Jeffreys, Amy S., Danus, Susanne, Passero, Vida, Goldstein, Karen M., and Kelley, Michael J.

Subjects
TUMOR diagnosis, RURAL health services, HEALTH services accessibility, NATIONAL health services, RESEARCH funding, INTEGRATED health care delivery, MEDICAL care of veterans, TELEMEDICINE, CANCER patient medical care, MEDICAL specialties & specialists, ONCOLOGISTS
Abstract

PURPOSE As the largest integrated health care system in the United States, the Veterans Health Administration (VA) is a leader in telehealth-delivered care. All 10 million Veterans cared for within the VA are eligible for telehealth. The VA cares for approximately 46,000 Veteran patients with newly diagnosed cancer and an estimated 400,000 prevalent cases annually. With nearly 38% of VA health care system users residing in rural areas and only 44% of rural counties having an oncologist, many Veterans lack local access to specialized cancer services. METHODS We describe the VA's National TeleOncology (NTO) Service. NTO was established to provide Veterans with the opportunity for specialized treatment regardless of geographical location. Designed as a hub-and-spoke model, VA oncologists from across the country can provide care to patients at spoke sites. Spoke sites are smaller and rural VA medical centers that are less able to independently provide the full range of services available at larger facilities. In addition to smaller rural spoke sites, NTO also provides subspecialized oncology care to Veterans located in larger VA medical facilities that do not have subspecialties available or that have limited capacity. RESULTS As of fiscal year 2021, 23 clinics are served by or engaged in planning for delivery of NTO and there are 24 physicians providing care through the NTO virtual hub. Most NTO physicians continue to provide patient care in separate traditional in-person clinics. Approximately 4,300 unique Veterans have used NTO services. Approximately half (52%) of Veterans using NTO lived in rural areas. Most of these Veterans had more than one remote visit through NTO. CONCLUSION NTO is a state-of-the-art model that has the potential to revolutionize the way cancer care is delivered, which should improve the experience of Veterans receiving cancer care. [ABSTRACT FROM AUTHOR]

Published
2023
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50. Characterization of T gene sequence variants and germline duplications in familial and sporadic chordoma

Author

Kelley, Michael J., Shi, Jianxin, Ballew, Bari, Hyland, Paula L., Li, Wen-Qing, Rotunno, Melissa, Alcorta, David A., Liebsch, Norbert J., Mitchell, Jason, Bass, Sara, Roberson, David, Boland, Joseph, Cullen, Michael, He, Ji, Burdette, Laurie, Yeager, Meredith, Chanock, Stephen J., Parry, Dilys M., Goldstein, Alisa M., and Yang, Xiaohong R.

Published
2014
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