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Your search keyword '"Kaur, Sukhwinder"' showing total 343 results
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343 results on '"Kaur, Sukhwinder"'

10. Disruption of FDPS/Rac1 axis radiosensitizes pancreatic ductal adenocarcinoma by attenuating DNA damage response and immunosuppressive signalling

Author

Seshacharyulu, Parthasarathy, Halder, Sushanta, Nimmakayala, Ramakrishna, Rachagani, Satyanarayana, Chaudhary, Sanjib, Atri, Pranita, Chirravuri-Venkata, Ramakanth, Ouellette, Michel M., Carmicheal, Joseph, Gautam, Shailendra K., Vengoji, Raghupathy, Wang, Shuo, Li, Sicong, Smith, Lynette, Talmon, Geoffrey A., Klute, Kelsey, Ly, Quan, Reames, Bradley N, Grem, Jean L, Berim, Lyudmyla, Padussis, James C, Kaur, Sukhwinder, Kumar, Sushil, Ponnusamy, Moorthy P., Jain, Maneesh, Lin, Chi, and Batra, Surinder K

Published
2022
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32. Growth and development assessment of children (1-5 years) operated for tracheoesophageal fistula/esophageal atresia: A case control study

Author

Maan, Monika, Kaur, Sukhwinder, Kalyan, Geetanjli, Samujh, Ram, Peters, Nitin, Bharti, Bhavneet, and Malhi, Prahbhjot

Subjects
Genetic disorders -- Analysis, Child development -- Analysis -- Growth, Company growth, Health
Abstract

Byline: Monika. Maan, Sukhwinder. Kaur, Geetanjli. Kalyan, Ram. Samujh, Nitin. Peters, Bhavneet. Bharti, Prahbhjot. Malhi Introduction: Among children, esophageal atresia (EA) with or without tracheoesophageal fistula (TEF) is one of [...]

Published
2021

35. Optimal treatment for obsessive compulsive disorder: a randomized controlled feasibility study of the clinical-effectiveness and cost-effectiveness of cognitive-behavioural therapy, selective serotonin reuptake inhibitors and their combination in the management of obsessive compulsive disorder

Author

Fineberg, Naomi A., Baldwin, David S., Drummond, Lynne M., Wyatt, Solange, Hanson, Jasmine, Gopi, Srinivas, Kaur, Sukhwinder, Reid, Jemma, Marwah, Virender, Sachdev, Ricky A., Pampaloni, Ilenia, Shahper, Sonia, Varlakova, Yana, Mpavaenda, Davis, Manson, Christopher, O’Leary, Cliodhna, Irvine, Karen, Monji-Patel, Deela, Shodunke, Ayotunde, Dyer, Tony, Dymond, Amy, Barton, Garry, and Wellsted, David

Published
2018
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37. In silico structural-functional characterization of three differentially expressed resistance gene analogs identi?ed in Dalbergia sissoo against dieback disease reveals their role in immune response regulation.

Author

Ijaz, Siddra, Ul Haq, Imran, Razzaq, Hafiza Arooj, Nasir, Bukhtawer, Ali, Hayssam M., and Kaur, Sukhwinder

Subjects
IMMUNOREGULATION, GENE expression, DIEBACK, DISEASE resistance of plants, GENES
Abstract

Plant immunity includes enemy recognition, signal transduction, and defensive response against pathogens. We experimented to identify the genes that contribute resistance against dieback disease to Dalbergia sissoo, an economically important timber tree. In this study, we investigated the role of three differentially expressed genes identified in the dieback-induced transcriptome in Dalbergia sissoo. The transcriptome was probed using DOP-rtPCR analysis. The identified RGAs were characterized in silico as the contributors of disease resistance that switch on under dieback stress. Their predicted fingerprints revealed involvement in stress response. Ds-DbRCaG-02-Rga.a, Ds-DbRCaG-04-Rga.b, and Ds-DbRCaG-06-Rga.c showed structural homology with the Transthyretin-52 domain, EAL associated YkuI_C domain, and Src homology-3 domain respectively, which are the attributes of signaling proteins possessing a role in regulating immune responses in plants. Based on in-silico structural and functional characterization, they were predicted to have a role in immune response regulation in D. sissoo. [ABSTRACT FROM AUTHOR]

Published
2023
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38. Formal Concept Analysis Applications in Bioinformatics.

Author

ROSCOE, SARAH, KHATRI, MINAL, VOSHALL, ADAM, BATRA, SURINDER, KAUR, SUKHWINDER, and DEOGUN, JITENDER

Subjects
COMPUTATIONAL biology, DEEP learning, NUCLEOTIDE sequencing, DRUG design, PROTEIN-protein interactions, BIOINFORMATICS, ONTOLOGIES (Information retrieval)
Abstract

The bioinformatics discipline seeks to solve problems in biology with computational theories and methods. Formal concept analysis (FCA) is one such theoretical model, based on partial orders. FCA allows the user to examine the structural properties of data based on which subsets of the dataset depend on each other. This article surveys the current literature related to the use of FCA for bioinformatics. The survey begins with a discussion of FCA, its hierarchical advantages, several advanced models of FCA, and lattice management strategies. It then examines how FCA has been used in bioinformatics applications, followed by future prospects of FCA in those areas. The applications addressed include gene data analysis (with next-generation sequencing), biomarkers discovery, protein-protein interaction, disease analysis (including COVID-19, cancer, and others), drug design and development, healthcare informatics, biomedical ontologies, and phylogeny. Some of the most promising prospects of FCA are identifying influential nodes in a network representing protein-protein interactions, determining critical concepts to discover biomarkers, integrating machine learning and deep learning for cancer classification, and pattern matching for next-generation sequencing. [ABSTRACT FROM AUTHOR]

Published
2023
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41. Pathobiological Implications of MUC4 in Non–Small-Cell Lung Cancer

Author

Majhi, Prabin Dhangada, Lakshmanan, Imayavaramban, Ponnusamy, Moorthy P., Jain, Maneesh, Das, Srustidhar, Kaur, Sukhwinder, Shimizu, Su Tomohiro, West, William W., Johansson, Sonny L., Smith, Lynette M., Yu, Fang, Rolle, Cleo E., Sharma, Poonam, Carey, George B., Batra, Surinder K., and Ganti, Apar Kishor

Published
2013
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44. Tumour exosome integrins determine organotropic metastasis

Author

Hoshino, Ayuko, Costa-Silva, Bruno, Shen, Tang-Long, Rodrigues, Goncalo, Hashimoto, Ayako, Tesic Mark, Milica, Molina, Henrik, Kohsaka, Shinji, Di Giannatale, Angela, Ceder, Sophia, Singh, Swarnima, Williams, Caitlin, Soplop, Nadine, Uryu, Kunihiro, Pharmer, Lindsay, King, Tari, Bojmar, Linda, Davies, Alexander E., Ararso, Yonathan, Zhang, Tuo, Zhang, Haiying, Hernandez, Jonathan, Weiss, Joshua M., Dumont-Cole, Vanessa D., Kramer, Kimberly, Wexler, Leonard H., Narendran, Aru, Schwartz, Gary K., Healey, John H., Sandstrom, Per, Jørgen Labori, Knut, Kure, Elin H., Grandgenett, Paul M., Hollingsworth, Michael A., de Sousa, Maria, Kaur, Sukhwinder, Jain, Maneesh, Mallya, Kavita, Batra, Surinder K., Jarnagin, William R., Brady, Mary S., Fodstad, Oystein, Muller, Volkmar, Pantel, Klaus, Minn, Andy J., Bissell, Mina J., Garcia, Benjamin A., Kang, Yibin, Rajasekhar, Vinagolu K., Ghajar, Cyrus M., Matei, Irina, Peinado, Hector, Bromberg, Jacqueline, and Lyden, David

Published
2015
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47. Botryosphaeria-related dieback and control investigated in noncoastal California grapevines

Author

Lynn Epstein, Kaur Sukhwinder, and Jean VanderGheynst

Subjects
Agriculture
Abstract

Dieback, or “dead arm,” in noncoastal California grapevines is most commonly caused by Botryosphaeria spp. Using Koch's postulates, we demonstrated that isolates of B. obtusa are pathogenic on grapevines. We initiated studies to investigate the life cycle of B. obtusa and ways to control it with cultural practices. Fungal spores disseminated by rainstorms were collected in traps in an Arbuckle vineyard from December 2006 through spring 2007. The data suggests that B. obtusa was rain-disseminated throughout winter and spring, and that pycnidia on deadwood in the vines is a major source of inoculum for new infections. Transmission may also be possible via vegetative propagation, pruning shears and insects. Durable latex paints were investigated for protecting pruning and surgical wounds; a self-priming latex paint was shown to be an effective barrier and was nonphytotoxic.

Published
2008
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48. In silico characterization of differentially expressed short-read nucleotide sequences identified in dieback stress-induced transcriptomic analysis reveals their role as antimicrobial peptides.

Author

Ijaz, Siddra, Ul Haq, Imran, Malik, Riffat, Nadeem, Ghalia, Ali, Hayssam M., and Kaur, Sukhwinder

Subjects
ANTIMICROBIAL peptides, PROTEIN kinase C, DIEBACK, PEPTIDE antibiotics, TRANSCRIPTOMES, MOLECULAR docking, PROTEIN kinase CK2
Abstract

We investigated the in silico characterization of short-length nucleotide sequences that were differentially expressed in dieback stress-induced transcriptomic analysis. They displayed homology with C-terminal flanking peptides and defensins-like proteins, revealing their antimicrobial activity. Their predicted fingerprints displayed protein signatures related to antimicrobial peptides. These short-length RGAs have been shown to possess structural motifs such as APLT P-type ATPase, casein kinase II (CK2), protein kinase 3, protein kinase C (PKC), and N-glycosylation site that are the attributes of disease resistance genes. The prediction of arginine and lysine residues in active binding sites in ligand docking analysis prophesied them as antimicrobial peptides due to their strong relation with antimicrobial activity. The in silico structural–functional characterization has predicted their role in resistance against microbial pathogens. Moreover, the predicted antimicrobial peptide regions showed their homology with the signature domain of PR-5-like protein and AMP family Thaumatin [ABSTRACT FROM AUTHOR]

Published
2023
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49. Phylogenomics resolves the etiology of dieback disease and deciphers Ceratocystis dalbergicans sp.nov., causal agent of Dalbergia sissoo decline.

Author

Ul Haq, Imran, Ijaz, Siddra, Latif, Muhammad Zunair, Khan, Iqrar Ahmad, Ali, Hayssam M., and Kaur, Sukhwinder

Subjects
ETIOLOGY of diseases, AGROFORESTRY, DIEBACK, PLANT cells & tissues, HORTICULTURE, FORESTS & forestry
Abstract

Dalbergia sissoo is one of the most economically important trees in forestry, agroforestry, and horticulture. This tree species is severely threatened by dieback. Widespread dieback outbreaks and infestations have drastically destroyed billions of D. sissoo trees. Hence, we attempted to resolve the dieback etiology through phylogenomics associated with D. sissoo mortality. The Ceratocystis species was evaluated using morphologically investigated fungal isolates collected from dieback-affected tissue plants. Based on the symptomatology, we have differentiated dieback from Fusarium wilt and concluded that the Ceratocystis fimbriata sensu lato complex is causing shisham dieback in Pakistan. As the Ceratocystis species complex is a cryptic species complex, we used genomics and phylogenetic analysis for deciphering its evolutionary hierarchical order. The pathogen's operational taxonomy was unlocked with the help of phylogenomics, and it was discovered that isolates from D. sissoo represent a species distinct from the other species in the C. fimbriata sensu lato species complex. The name Ceratocystis dalbergicans sp. nov. has been given to the fungus causing dieback disease in D. sissoo. [ABSTRACT FROM AUTHOR]

Published
2023
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50. Evaluation of a nurse-led counselling intervention on selected outcome variables for parents of children with congenital adrenal hyperplasia.

Author

Verma, Poonam, Sharma, Sunita, Kaur, Sukhwinder, Rohilla, Latika, Malhi, Prahbhjot, and Dayal, Devi

Abstract

Long-term care of children with congenital adrenal hyperplasia (CAH) has psycho-social implications for parents. Experts recommend a customized educational program for parents to facilitate their psychological adaptation and improve disease management. Such educational programs often provided by nurse counsellors are well evaluated in developed countries. There is a dearth of data on nurse-led counselling in the context of less developed countries. We aimed to evaluate the effect of a nurse-led counselling intervention on various psycho-social outcomes among parents of children with CAH. Fifty consecutive parents of children with CAH attending an outpatient clinic at a tertiary-care teaching hospital were enrolled. Parents' stress level, stigma, knowledge, practices, and treatment adherence were assessed by using Cohen's Perceived Stress Scale (PSS), DSD Stigma scale, and HILL-Bon Medication Adherence Scale (HB-MAS). Three educational counselling sessions were conducted within a month's gap, using PowerPoint presentations and a booklet. Assessment of outcomes was done at baseline and at the end of the third session. At baseline, the majority (90%) of the parents had moderate stress. Half of the parents had mild and the rest had moderate stigma. After the intervention, the majority (94%) of parents had shifted to mild levels of stress and stigma. At baseline, 86% of the parents had poor knowledge about the disease whereas post-intervention, 80% were having good knowledge. Disease management practices and treatment adherence also improved after the intervention. Nurse-led counselling was effective in reducing psycho-social problems, increasing knowledge, as well as improving practices and treatment adherence. [ABSTRACT FROM AUTHOR]

Published
2023
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