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5. A prospective prostate cancer screening programme for men with pathogenic variants in mismatch repair genes (IMPACT): initial results from an international prospective study

Author

Adams, Lisa, Adlard, Julian, Alfonso, Rosa, Ali, Saira, Andrew, Angela, Araújo, Luís, Azam, Nazya, Ball, Darran, Barker, Queenstone, Basevitch, Alon, Benton, Barbara, Berlin, Cheryl, Bermingham, Nicola, Biller, Leah, Bloss, Angela, Bradford, Matilda, Bradshaw, Nicola, Branson, Amy, Brendler, Charles, Brennan, Maria, Bulman, Barbara, Burgess, Lucy, Cahill, Declan, Callard, Alice, Calvo Verges, Nuria, Cardoso, Marta, Carter, Vanda, Catanzaro, Mario, Chamberlain, Anthony, Chapman, Cyril, Chong, Michael, Clark, Caroline, Clowes, Virginia, Cogley, Lyn, Cole, Trevor, Compton, Cecilia, Conner, Tom, Cookson, Sandra, Cornford, Philip, Costello, Philandra, Coulier, Laura, Davies, Michaela, Dechet, Christopher, DeSouza, Bianca, Devlin, Gemma, Douglas, Fiona, Douglas, Emma, Dudakia, Darshna, Duncan, Alexis, Ellery, Natalie, Everest, Sarah, Freemantle, Sue, Frydenberg, Mark, Fuller, Debbie, Gabriel, Camila, Gale, Madeline, Garcia, Lynda, Gay, Simona, Genova, Elena, George, Angela, Georgiou, Demetra, Gisbert, Alexandra, Gleeson, Margaret, Glover, Wayne, Gnanapragasam, Vincent, Goff, Sally, Goldgar, David, Gonçalves, Nuno, Goodman, Selina, Gorrie, Jennifer, Gott, Hannah, Grant, Anna, Gray, Catherine, Griffiths, Julie, Gupwell, Karin, Gurasashvili, Jana, Hanslien, Eldbjørg, Haraldsdottir, Sigurdis, Hart, Rachel, Hartigan, Catherine, Hawkes, Lara, Heaton, Tricia, Henderson, Alex, Henrique, Rui, Hilario, Kathrine, Hill, Kathryn, Hulick, Peter, Hunt, Clare, Hutchings, Melanie, Ibitoye, Rita, Inglehearn, Thomas, Ireland, Joanna, Islam, Farah, Ismail, Siti, Jacobs, Chris, James, Denzil, Jenkins, Sharon, Jobson, Irene, Johnstone, Anne, Jones, Oliver, Josefsberg Ben-Yehoshua, Sagi, Kaemba, Beckie, Kaul, Karen, Kemp, Zoe, Kinsella, Netty, Klehm, Margaret, Kockelbergh, Roger, Kohut, Kelly, Kosicka-Slawinska, Monika, Kulkarni, Anjana, Kumar, Pardeep, Lam, Jimmy, LeButt, Mandy, Leibovici, Dan, Lim, Ramona, Limb, Lauren, Lomas, Claire, Longmuir, Mark, López, Consol, Magnani, Tiziana, Maia, Sofia, Maiden, Jessica, Male, Alison, Manalo, Merrie, Martin, Phoebe, McBride, Donna, McGuire, Michael, McMahon, Romayne, McNally, Claire, McVeigh, Terri, Melzer, Ehud, Mencias, Mark, Mercer, Catherine, Mitchell, Gillian, Mora, Josefina, Morton, Catherine, Moss, Cathryn, Murphy, Morgan, Murphy, Declan, Mzazi, Shumi, Nadolski, Maria, Newlin, Anna, Nogueira, Pedro, O'Keefe, Rachael, O'Toole, Karen, O'Connell, Shona, Ogden, Chris, Okoth, Linda, Oliveira, Jorge, Paez, Edgar, Palou, Joan, Park, Linda, Patel, Nafisa, Paulo Souto, João, Pearce, Allison, Peixoto, Ana, Perez, Kimberley, Petelin, Lara, Pichert, Gabriella, Poile, Charlotte, Potter, Alison, Preitner, Nadia, Purnell, Helen, Quinn, Ellen, Radice, Paolo, Rankin, Brigette, Rees, Katie, Renton, Caroline, Richardson, Kate, Risby, Peter, Rogers, Jason, Ruderman, Maggie, Ruiz, April, Sajoo, Anaar, Salvatore, Natale, Sands, Victoria, Sanguedolce, Francesco, Sattar, Ayisha, Saunders, Kathryn, Schofield, Lyn, Scott, Rodney, Searle, Anne, Sehra, Ravinder, Selkirk, Christina, Shackleton, Kylie, Shanley, Sue, Shaw, Adam, Shevrin, Daniel, Shipman, Hannah, Sidat, Zahirah, Siguake, Kas, Simon, Kate, Smyth, Courtney, Snadden, Lesley, Solanky, Nita, Solomons, Joyce, Sorrentino, Margherita, Stayner, Barbara, Stephenson, Robert, Stoffel, Elena, Thomas, Maggie, Thompson, Alan, Tidey, Lizzie, Tischkowitz, Marc, Torokwa, Audrey, Townshend, Sharron, Treherne, Katy, Tricker, Karen, Trinh, Quoc-Dien, Tripathi, Vishakha, Turnbull, Clare, Valdagni, Riccardo, Van As, Nicholas, Venne, Vickie, Verdon, Lizzie, Vitellaro, Marco, Vogel, Kristen, Walker, Lisa, Watford, Amy, Watt, Cathy, Weintroub, Ilana, Weiss, Shelly, Weissman, Scott, Weston, Michelle, Wiggins, Jennifer, Wise, Gillian, Woodhouse, Christopher, Yesildag, Pembe, Youngs, Alice, Yurgelun, Matthew, Zollo, Fabiana, Bancroft, Elizabeth K, Page, Elizabeth C, Brook, Mark N, Thomas, Sarah, Taylor, Natalie, Pope, Jennifer, McHugh, Jana, Jones, Ann-Britt, Karlsson, Questa, Merson, Susan, Ong, Kai Ren, Hoffman, Jonathan, Huber, Camilla, Maehle, Lovise, Grindedal, Eli Marie, Stormorken, Astrid, Evans, D Gareth, Rothwell, Jeanette, Lalloo, Fiona, Brady, Angela F, Bartlett, Marion, Snape, Katie, Hanson, Helen, James, Paul, McKinley, Joanne, Mascarenhas, Lyon, Syngal, Sapna, Ukaegbu, Chinedu, Side, Lucy, Thomas, Tessy, Barwell, Julian, Teixeira, Manuel R, Izatt, Louise, Suri, Mohnish, Macrae, Finlay A, Poplawski, Nicola, Chen-Shtoyerman, Rakefet, Ahmed, Munaza, Musgrave, Hannah, Nicolai, Nicola, Greenhalgh, Lynn, Brewer, Carole, Pachter, Nicholas, Spigelman, Allan D, Azzabi, Ashraf, Helfand, Brian T, Halliday, Dorothy, Buys, Saundra, Ramon y Cajal, Teresa, Donaldson, Alan, Cooney, Kathleen A, Harris, Marion, McGrath, John, Davidson, Rosemarie, Taylor, Amy, Cooke, Peter, Myhill, Kathryn, Hogben, Matthew, Aaronson, Neil K, Ardern-Jones, Audrey, Bangma, Chris H, Castro, Elena, Dearnaley, David, Dias, Alexander, Dudderidge, Tim, Eccles, Diana M, Green, Kate, Eyfjord, Jorunn, Falconer, Alison, Foster, Christopher S, Gronberg, Henrik, Hamdy, Freddie C, Johannsson, Oskar, Khoo, Vincent, Lilja, Hans, Lindeman, Geoffrey J, Lubinski, Jan, Axcrona, Karol, Mikropoulos, Christos, Mitra, Anita V, Moynihan, Clare, Ni Raghallaigh, Holly, Rennert, Gad, Collier, Rebecca, Offman, Judith, Kote-Jarai, Zsofia, and Eeles, Rosalind A

Published
2021
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15. Teaching Genomic Pathology: Translating Team-Based Learning to a Virtual Environment Using Computer-Based Simulation

Author

Haspel, Richard L., Ali, Asma M., Huang, Grace C., Smith, Matt H., Atkinson, James B., Chabot-Richards, Devon S., Elliott, Robin M., Kaul, Karen L., Powell, Suzanne Z., Rao, Arundhati, Rinder, Henry M., Vanderbilt, Chad M., and Wilcox, Rebecca

Subjects
Molecular pathology -- Research, Computer simulation -- Usage, Education, Teachers, Email, Genomics, Workshops (Educational programs), Teamwork (Workplace), Novels, Health
Abstract

Context.--Developing skills related to use of computer-based tools is critical for practicing genomic pathology. However, given the relative novelty of genomics education, residency programs may lack faculty members with adequate expertise and/or time to implement training. A virtual team-based learning (TBL) environment would make genomic pathology education available to more trainees. Objective.--To translate an extensively implemented in-person TBL genomic pathology workshop into a virtual environment and to evaluate both knowledge and skill acquisition. Design.--Using a novel interactive simulation approach, online modules were developed translating aspects of the TBL experience into the virtual environment with a goal of acquisition of necessary computer-related skills. The modules were evaluated at 10 postgraduate pathology training programs using a pre-post test design with participants deidentified. A postmodule anonymous survey obtained participant feedback on module quality and efficacy. Results.--There were 147 trainees who received an email request to voluntarily participate in the study. Of these, 43 trainees completed the pretest and 15 (35%) subsequently completed the posttest. Mean overall scores were 45% on the pretest compared with 70% on the posttest (P < .001; effect size = 1.4). Posttest improvement of results was similar for questions testing acquisition of knowledge versus skills. Regarding the 19 participants who took the survey, 18 (95%) would recommend the modules to others and believed they met the stated objectives. Conclusions.--A simulation-based approach allows motivated pathology trainees to acquire computer-related skills for practicing genomic pathology. Future work can explore efficacy in a nonvoluntary setting and adaptation to different specialties, learners, and computer tools. (Arch Pathol Lab Med. 2019;143:513-517; doi: 10.5858/arpa.2018-0153-OA), Pathologists must acquire genomic medicine-related knowledge and skills to provide the best possible patient care. (1, 2) Specifically, to adequately analyze genomic data, it is critical to develop proficiency in [...]

Published
2019
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20. Author Correction: Integrated molecular subtyping defines a curable oligometastatic state in colorectal liver metastasis

Author

Pitroda, Sean P., Khodarev, Nikolai N., Huang, Lei, Uppal, Abhineet, Wightman, Sean C., Ganai, Sabha, Joseph, Nora, Pitt, Jason, Brown, Miguel, Forde, Martin, Mangold, Kathy, Xue, Lai, Weber, Christopher, Segal, Jeremy P., Kadri, Sabah, Stack, Melinda E., Khan, Sajid, Paty, Philip, Kaul, Karen, Andrade, Jorge, White, Kevin P., Talamonti, Mark, Posner, Mitchell C., Hellman, Samuel, and Weichselbaum, Ralph R.

Published
2018
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21. Integrated molecular subtyping defines a curable oligometastatic state in colorectal liver metastasis

Author

Pitroda, Sean P., Khodarev, Nikolai N., Huang, Lei, Uppal, Abhineet, Wightman, Sean C., Ganai, Sabha, Joseph, Nora, Pitt, Jason, Brown, Miguel, Forde, Martin, Mangold, Kathy, Xue, Lai, Weber, Christopher, Segal, Jeremy P., Kadri, Sabah, Stack, Melinda E., Khan, Sajid, Paty, Philip, Kaul, Karen, Andrade, Jorge, White, Kevin P., Talamonti, Mark, Posner, Mitchell C., Hellman, Samuel, and Weichselbaum, Ralph R.

Published
2018
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24. Regulation of laboratory-developed tests: scoping the issue.

Author

Kroft, Steven H and Kaul, Karen L

Subjects
*TESTING laboratories, *PATHOLOGICAL laboratories, *MEDICAL equipment, *INTERNET content management systems, *MEDICAL laboratories, *MEDICAL laws, *HOSPITALS, *HOSPITAL laboratories
Abstract

Additionally, unknown samples for each analyte tested in the lab are distributed multiple times per year (proficiency testing); the lab analyzes these samples and returns the results so that they can be compared with results from other labs across the country. Hospital laboratories perform hundreds, even thousands of different tests to support the care of the patients they serve. [Extracted from the article]

Published
2023
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30. Comparison of tumor markers for predicting outcomes after resection of nonfunctioning pancreatic neuroendocrine tumors

Author

Cherenfant, Jovenel, Talamonti, Mark S., Hall, Curtis R., Thurow, Tiffany A., Gage, Mistry K., Stocker, Susan J., Lapin, Brittany, Wang, Edward, Silverstein, Jonathan C., Mangold, Kathy, Odeleye, Melanie, Kaul, Karen L., Lamzabi, Ihab, Gattuso, Paolo, Winchester, David J., Marsh, Robert W., Roggin, Kevin K., Bentrem, David J., Baker, Marshall S., and Prinz, Richard A.

Published
2014
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31. Detection of toxigenic Clostridium difficile in stool samples by real-time polymerase chain reaction for the diagnosis of C. difficile - associated diarrhea

Author

Peterson, Lance R., Manson, Rebecca U., Paule, Suzanne M., Hacek, Donna M., Robicsek, Ari, Thomson, Richard B. Jr., and Kaul, Karen L.

Subjects
Clostridium difficile -- Health aspects, Clostridium difficile -- Physiological aspects, Diarrhea -- Causes of, Diarrhea -- Care and treatment, Polymerase chain reaction -- Usage, Health, Health care industry
Published
2007

42. Clinical characteristics and viral load dynamics of COVID-19 in a mildly or moderately symptomatic outpatient sample.

Author

Caplan, Amanda, Bates, Kelly W., Brioni, Carla, Santos, Aileen, Sabatini, Linda M., Kaul, Karen L., Carnethon, Mercedes R., Khandekar, Janardan D., and Greenland, Philip

Subjects
COVID-19, REVERSE transcriptase polymerase chain reaction, VIRAL load, OUTPATIENTS, COVID-19 testing
Abstract

Background: Studies of outpatients with mild or moderate COVID-19 are uncommon. We studied: 1) association of symptoms with reverse transcriptase polymerase chain reaction (RT-PCR) test results; and 2) association of initial RT-PCR cycle threshold (Ct) in relation to duration of RT-PCR positivity in outpatients with mild or moderate COVID-19. Methods: This was a cohort study of outpatients with confirmed COVID-19 and at least one symptom. Participants had repeat nasopharyngeal swabs and symptom checklists every 3–5 days until two consecutive RT-PCR tests were negative. RT-PCR tests were used to assess viral load. Antibody tests for COVID-19 were performed at 2 weeks, 4 weeks, and 8 weeks after symptom onset. Results: Twenty-five patients (nine females) were enrolled, ranging in age from 19–58 (median age 28 years). All patients reported at least one symptom, with a median of six symptoms per patient. Symptoms persisted for 6–67 days (median duration 18 days). In all 25 patients, blood samples collected a median of 13 days after symptom onset were positive for SARS-CoV-2 antibodies in 15 (60%). After a median of 28 days following symptom onset, 23/23 patients with available samples tested positive for antibodies. The longest duration of positive RT-PCR test was 49 days from first positive PCR test (Mean = 27.4, SD = 12.5, Median = 24). Initial Ct was significantly associated with longer duration (β = -1.3, SE = 0.3, p<0.01 per 1 cycle higher) of RT-PCR positivity. Conclusions: In mildly or moderately ill COVID-19 outpatients, RT-PCT tests remained positive for as long as 49 days and test positivity and symptom duration correlated with initial viral load. [ABSTRACT FROM AUTHOR]

Published
2021
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43. The Need for Molecular Pathologists

Author

Kaul, Karen

Subjects
Precision medicine, Health care reform, Algorithms, Physicians, Pharmacogenomics, Genomics, Teamwork (Workplace), Business, Health care industry
Abstract

Clinical medicine is increasingly complex, with a constant evolution in laboratory tests, diagnostic algorithms and consensus guidelines. Practicing clinicians are challenged to keep current with the rapid advances in laboratory [...]

Published
2020

49. Progress and Potential: Training in Genomic Pathology

Author

Haspel, Richard L., Olsen, Randall J., Berry, Anna, Hill, Charles E., Pfeifer, John D., Schrijver, Iris, and Kaul, Karen L.

Subjects
Communicable diseases, Patients -- Care and treatment, Genomics, Medical laboratories, Genetic screening, Health
Abstract

Context.--Genomic medicine is revolutionizing patient care. Physicians in areas as diverse as oncology, obstetrics, and infectious disease have begun using next-generation sequencing assays as standard diagnostic tools. Objective.--To review the role of pathologists in genomic testing as well as current educational programs and future training needs in genomic pathology. Data Sources.--Published literature as well as personal experience based on committee membership and genomic pathology curricular design. Conclusion.--Pathologists, as the directors of the clinical laboratories, must be prepared to integrate genomic testing into their practice. The pathology community has made significant progress in genomics-related education. A continued coordinated and proactive effort will ensure a future vital role for pathologists in the evolving health care system and also the best possible patient care. (Arch Pathol Lab Med. 2014; 138:498-504; doi: 10.5858/arpa.2013-0359-SA), An entire human genome can currently be sequenced for less than $10 000 in several weeks, with further reduction in cost and time anticipated. (1) Multigene panels and next-generation sequencing [...]

Published
2014
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