25 results on '"Katz, Yarden"'
Search Results
2. High-fat diet enhances stemness and tumorigenicity of intestinal progenitors
- Author
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Beyaz, Semir, Mana, Miyeko D., Roper, Jatin, Kedrin, Dmitriy, Saadatpour, Assieh, Hong, Sue-Jean, Bauer-Rowe, Khristian E., Xifaras, Michael E., Akkad, Adam, Arias, Erika, Pinello, Luca, Katz, Yarden, Shinagare, Shweta, Abu-Remaileh, Monther, Mihaylova, Maria M., Lamming, Dudley W., Dogum, Rizkullah, Guo, Guoji, Bell, George W., Selig, Martin, Nielsen, G. Petur, Gupta, Nitin, Ferrone, Cristina R., Deshpande, Vikram, Yuan, Guo-Cheng, Orkin, Stuart H., Sabatini, David M., and Yilmaz, mer H.
- Subjects
High fat diet -- Health aspects ,Cancer research ,Carcinogenesis -- Research ,Environmental issues ,Science and technology ,Zoology and wildlife conservation - Abstract
Little is known about how pro-obesity diets regulate tissue stem and progenitor cell function. Here we show that high-fat diet (HFD)-induced obesity augments the numbers and function of Lgr5[sup.+] intestinal stem cells of the mammalian intestine. Mechanistically, a HFD induces a robust peroxisome proliferator-activated receptor delta (PPAR-) signature in intestinal stem cells and progenitor cells (non-intestinal stem cells), and pharmacological activation of PPAR- recapitulates the effects of a HFD on these cells. Like a HFD, ex vivo treatment of intestinal organoid cultures with fatty acid constituents of the HFD enhances the self-renewal potential of these organoid bodies in a PPAR--dependent manner. Notably, HFD- and agonist-activated PPAR- signalling endow organoid-initiating capacity to progenitors, and enforced PPAR- signalling permits these progenitors to form in vivo tumours after loss of the tumour suppressor Apc. These findings highlight how diet-modulated PPAR- activation alters not only the function of intestinal stem and progenitor cells, but also their capacity to initiate tumours., Author(s): Semir Beyaz [1, 2]; Miyeko D. Mana [1]; Jatin Roper [1, 3]; Dmitriy Kedrin [1, 4]; Assieh Saadatpour [5]; Sue-Jean Hong [6]; Khristian E. Bauer-Rowe [1]; Michael E. Xifaras [...]
- Published
- 2016
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3. Artificial Whiteness : Politics and Ideology in Artificial Intelligence
- Author
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KATZ, YARDEN and KATZ, YARDEN
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- 2020
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4. Author Correction: High-fat diet enhances stemness and tumorigenicity of intestinal progenitors
- Author
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Beyaz, Semir, Mana, Miyeko D., Roper, Jatin, Kedrin, Dmitriy, Saadatpour, Assieh, Hong, Sue-Jean, Bauer-Rowe, Khristian E., Xifaras, Michael E., Akkad, Adam, Arias, Erika, Pinello, Luca, Katz, Yarden, Shinagare, Shweta, Abu-Remaileh, Monther, Mihaylova, Maria M., Lamming, Dudley W., Dogum, Rizkullah, Guo, Guoji, Bell, George W., Selig, Martin, Nielsen, G. Petur, Gupta, Nitin, Ferrone, Cristina R., Deshpande, Vikram, Yuan, Guo-Cheng, Orkin, Stuart H., Sabatini, David M., and Yilmaz, Ömer H.
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- 2018
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5. Probabilistic Inference with Polymerizing Biochemical Circuits.
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Katz, Yarden and Fontana, Walter
- Subjects
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LINEAR polymers , *UNICELLULAR organisms , *MORPHOLOGY , *MARKOV processes , *POLYMERIZATION , *BIOCHEMICAL models , *PROBABILISTIC number theory - Abstract
Probabilistic inference—the process of estimating the values of unobserved variables in probabilistic models—has been used to describe various cognitive phenomena related to learning and memory. While the study of biological realizations of inference has focused on animal nervous systems, single-celled organisms also show complex and potentially "predictive" behaviors in changing environments. Yet, it is unclear how the biochemical machinery found in cells might perform inference. Here, we show how inference in a simple Markov model can be approximately realized, in real-time, using polymerizing biochemical circuits. Our approach relies on assembling linear polymers that record the history of environmental changes, where the polymerization process produces molecular complexes that reflect posterior probabilities. We discuss the implications of realizing inference using biochemistry, and the potential of polymerization as a form of biological information-processing. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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6. Pellet: A practical OWL-DL reasoner
- Author
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Sirin, Evren, Parsia, Bijan, Grau, Bernardo Cuenca, Kalyanpur, Aditya, and Katz, Yarden
- Published
- 2007
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7. Intelligence Under Racial Capitalism: From Eugenics to Standardized Testing and Online Learning.
- Author
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KATZ, YARDEN
- Subjects
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SOCIAL scientists , *ONLINE education , *CAPITALISM , *INTELLIGENCE tests , *ADLERIAN psychology , *EUGENICS , *STANDARDIZED tests - Abstract
The article discusses the concepts of intelligence based on racial capitalism that focus on the differences among people on factors like religion, race, country and reproductive and physical abilities. Other topics include how racialism is deeply embedded in Western culture as per Cedric Robinson, and the changes in the regimes of racial intelligence including the eugenic regime, the regime of standardized testing, and the regime of online learning.
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- 2022
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8. Embodying probabilistic inference in biochemical circuits
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Katz, Yarden, Springer, Michael, and Fontana, Walter
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Molecular Networks (q-bio.MN) ,FOS: Biological sciences ,Quantitative Biology - Neurons and Cognition ,Neurons and Cognition (q-bio.NC) ,Quantitative Biology - Molecular Networks - Abstract
Probabilistic inference provides a language for describing how organisms may learn from and adapt to their environment. The computations needed to implement probabilistic inference often require specific representations, akin to having the suitable data structures for implementing certain algorithms in computer programming. Yet it is unclear how such representations can be instantiated in the stochastic, parallel-running biochemical machinery found in cells (such as single-celled organisms). Here, we show how representations for supporting inference in Markov models can be embodied in cellular circuits, by combining a concentration-dependent scheme for encoding probabilities with a mechanism for directional counting. We show how the logic of protein production and degradation constrains the computation we set out to implement. We argue that this process by which an abstract computation is shaped by its biochemical realization strikes a compromise between "rationalistic" information-processing perspectives and alternative approaches that emphasize embodiment., 11 figures
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- 2018
9. Metrics of Inequality: The Concentration of Resources in the U.S. Biomedical Elite.
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Katz, Yarden and Matter, Ulrich
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MATHEMATICAL equivalence , *MEDICAL sciences , *POLICY sciences , *RESEARCH institutes , *BIBLIOMETRICS , *BIBLIOTHERAPY - Abstract
Academic scientists and research institutes are increasingly being evaluated using digital metrics, from bibliometrics to patent counts. These metrics are often framed, by science policy analysts, economists of science as well as funding agencies, as objective and universal proxies for scientific worth, potential, and productivity. In biomedical science, where there is stiff competition for grants from the National Institutes of Health (NIH), metrics are sold as a less arbitrary way to allocate funds, yet the funding context in which metrics are applied is not critically examined. Success by the metrics is in fact inextricably linked to the distribution of NIH funds, and from the 1980s to the 2000s, NIH funding has been marked by high inequality (elite investigators and institutes get the lion's share of resources) and decreased mobility (those who start at the bottom are less likely to rise to the upper ranks). Elite investigators and institutes currently produce the bulk of prestigious publications, citations, and patents that commonly used metrics valorise. Metrics-based evaluation therefore reproduces, and potentially amplifies, existing inequalities in academic science and rich-get-richer effects. [ABSTRACT FROM AUTHOR]
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- 2020
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10. On the Biomedical Elite: Inequality and Stasis in Scientific Knowledge Production
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Katz, Yarden and Matter, Ulrich
- Subjects
economics ,other research area ,social sciences - Abstract
Researchers and research institutes are increasingly being evaluated using metrics (from bibliometrics to patent counts), which are core instruments of a longstanding effort to quantify scientific productivity and worth. Here, we examine the relationship between commonly used metrics and funding levels for investigators funded by the National Institutes of Health, the largest public funder of biomedical research in the United States, in the years 1985-2015. We find that funding inequality has been rising since 1985, with a small segment of investigators and institutes getting an increasing proportion of funds, and that investigators who start in the top funding ranks tend to stay there (which results in stasis, or lack of mobility). Furthermore, funding levels are a strong quantitative predictor of the interrelated set of metrics frequently used by economists and policy makers to evaluate scientific research. Our results suggest that the widespread system of metrics favors a minority of elite, highly funded researchers and institutes. Current attempts to “optimize” science are inextricably linked to the concentration of funds in the biomedical research system and are likely to further reduce diversity in the research community.
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- 2017
11. Modeling Semantic Cognition as Logical Dimensionality Reduction
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Katz, Yarden, Goodman, Noah D., Kersting, Kristian, Kemp, Charles, and Tenenbaum, Joshua B.
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Social and Behavioral Sciences - Published
- 2008
12. A single-cell survey of the small intestinal epithelium
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Haber, Adam L., Biton, Moshe, Rogel, Noga, Herbst, Rebecca H., Shekhar, Karthik, Smillie, Christopher, Burgin, Grace, Delorey, Toni M., Howitt, Michael R., Katz, Yarden, Tirosh, Itay, Beyaz, Semir, Dionne, Danielle, Zhang, Mei, Raychowdhury, Raktima, Garrett, Wendy S., Rozenblatt-Rosen, Orit, Shi, Hai Ning, Yilmaz, Omer, Xavier, Ramnik J., and Regev, Aviv
- Abstract
Intestinal epithelial cells (IECs) absorb nutrients, respond to microbes, provide barrier function and help coordinate immune responses. We profiled 53,193 individual epithelial cells from mouse small intestine and organoids, and characterized novel subtypes and their gene signatures. We showed unexpected diversity of hormone-secreting enteroendocrine cells and constructed their novel taxonomy. We distinguished between two tuft cell subtypes, one of which expresses the epithelial cytokine TSLP and CD45 (Ptprc), the pan-immune marker not previously associated with non-hematopoietic cells. We also characterized how cell-intrinsic states and cell proportions respond to bacterial and helminth infections. Salmonella infection caused an increase in Paneth cells and enterocytes abundance, and broad activation of an antimicrobial program. In contrast, Heligmosomoides polygyrus caused an expansion of goblet and tuft cell populations. Our survey highlights new markers and programs, associates sensory molecules to cell types, and uncovers principles of gut homeostasis and response to pathogens.
- Published
- 2018
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13. Resisting Eugenics and Racial Capitalism.
- Author
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KATZ, YARDEN
- Abstract
The article highlight the story of Shifra and Puah from the Book of Exodus in the Hebrew Bible and draw connections to contemporary issues of racial capitalism, eugenics, and racial ideology. It emphasizes the role of Shifra and Puah as revolutionary figures who resisted orders to kill newborn Hebrew males and refused to implement eugenics. It argues that the story of Exodus serves as a cautionary tale about racial capitalism and calls for the disruption of systems of racialized extraction.
- Published
- 2023
14. Spatial Attention and Temporal Expectation Under Timed Uncertainty Predictably Modulate Neuronal Responses in Monkey V1.
- Author
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Sharma, Jitendra, Hiroki Sugihara, Katz, Yarden, Schummers, James, Tenenbaum, Joshua, and Sur, Mriganka
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- 2015
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15. Representing Web Service Policies in OWL-DL.
- Author
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Gil, Yolanda, Motta, Enrico, Benjamins, V. Richard, Musen, Mark A., Kolovski, Vladimir, Parsia, Bijan, Katz, Yarden, and Hendler, James
- Abstract
Recently, there have been a number of proposals for languages for expressing web service constraints and capabilities, with WS-Policy and WSPL leading the way. The proposed languages, although relatively inexpressive, suffer from a lack of formal semantics. In this paper, we provide a mapping of WS-Policy to the description logic fragment species of the Web Ontology Language (OWL-DL), and describe how standard OWL-DL reasoners can be used to check policy conformance and perform an array of policy analysis tasks. OWL-DL is much more expressive than WS-Policy and thus provides a framework for exploring richer policy languages. [ABSTRACT FROM AUTHOR]
- Published
- 2005
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16. Probabilistic adaptation in changing microbial environments
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Katz, Yarden and Springer, Michael
- Subjects
Synthetic Biology ,Mathematical Biology ,Computational Biology ,Ecology ,Microbiology ,Systems Biology ,Epigenetic adaptation ,Bayesian inference ,gut microbiota ,cellular circuits - Abstract
Microbes growing in animal host environments face fluctuations that have elements of both randomness and predictability. In the mammalian gut, fluctuations in nutrient levels and other physiological parameters are structured by the animal host’s behavior, diet, health and microbiota composition. Microbial cells that are able to anticipate these fluctuations by exploiting this structure would likely gain a fitness advantage, by adapting their internal state in advance. We propose that the problem of adaptive growth in these structured changing environments can be viewed as probabilistic inference. We analyze environments that are “meta-changing”: where there are changes in the way the environment fluctuates, governed by a mechanism unobservable to cells. We develop a dynamic Bayesian model of these environments and show that a real-time inference algorithm (particle filtering) for this model can be used as a microbial growth strategy implementable in molecular circuits. The growth strategy suggested by our model outperforms heuristic strategies, and points to a class of algorithms that could support real-time probabilistic inference in natural or synthetic cellular circuits.
- Published
- 2016
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17. Multiplexed activation of endogenous genes by CRISPR-on, an RNA-guided transcriptional activator system.
- Author
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Cheng, Albert W, Wang, Haoyi, Yang, Hui, Shi, Linyu, Katz, Yarden, Theunissen, Thorold W, Rangarajan, Sudharshan, Shivalila, Chikdu S, Dadon, Daniel B, and Jaenisch, Rudolf
- Subjects
GENETIC regulation ,RNA ,REPORTER genes ,GENOMES ,ZYGOTES - Abstract
Technologies allowing for specific regulation of endogenous genes are valuable for the study of gene functions and have great potential in therapeutics. We created the CRISPR-on system, a two-component transcriptional activator consisting of a nuclease-dead Cas9 (dCas9) protein fused with a transcriptional activation domain and single guide RNAs (sgRNAs) with complementary sequence to gene promoters. We demonstrate that CRISPR-on can efficiently activate exogenous reporter genes in both human and mouse cells in a tunable manner. In addition, we show that robust reporter gene activation in vivo can be achieved by injecting the system components into mouse zygotes. Furthermore, we show that CRISPR-on can activate the endogenous IL1RN, SOX2, and OCT4 genes. The most efficient gene activation was achieved by clusters of 3-4 sgRNAs binding to the proximal promoters, suggesting their synergistic action in gene induction. Significantly, when sgRNAs targeting multiple genes were simultaneously introduced into cells, robust multiplexed endogenous gene activation was achieved. Genome-wide expression profiling demonstrated high specificity of the system. [ABSTRACT FROM AUTHOR]
- Published
- 2013
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18. Analysis and design of RNA sequencing experiments for identifying isoform regulation.
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Katz, Yarden, Wang, Eric T., Airoldi, Edoardo M., and Burge, Christopher B.
- Subjects
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RNA , *DNA , *EXONS (Genetics) , *SPLIT genes , *GENES - Abstract
Through alternative splicing, most human genes express multiple isoforms that often differ in function. To infer isoform regulation from high-throughput sequencing of cDNA fragments (RNA-seq), we developed the mixture-of-isoforms (MISO) model, a statistical model that estimates expression of alternatively spliced exons and isoforms and assesses confidence in these estimates. Incorporation of mRNA fragment length distribution in paired-end RNA-seq greatly improved estimation of alternative-splicing levels. MISO also detects differentially regulated exons or isoforms. Application of MISO implicated the RNA splicing factor hnRNP H1 in the regulation of alternative cleavage and polyadenylation, a role that was supported by UV cross-linking-immunoprecipitation sequencing (CLIP-seq) analysis in human cells. Our results provide a probabilistic framework for RNA-seq analysis, give functional insights into pre-mRNA processing and yield guidelines for the optimal design of RNA-seq experiments for studies of gene and isoform expression. [ABSTRACT FROM AUTHOR]
- Published
- 2010
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19. Quantitative visualization of alternative exon expression from RNA-seq data.
- Author
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Katz, Yarden, Wang, Eric T., Silterra, Jacob, Schwartz, Schraga, Bang Wong, Thorvaldsdóttir, Helga, Robinson, James T., Mesirov, Jill P., Airoldi, Edoardo M., and Burge, Christopher B.
- Subjects
- *
RNA sequencing , *EXONS (Genetics) , *GENE expression , *MESSENGER RNA , *GENETIC engineering - Abstract
Motivation: Analysis of RNA sequencing (RNA-Seq) data revealed that the vast majority of human genes express multiple mRNA isoforms, produced by alternative pre-mRNA splicing and other mechanisms, and that most alternative isoforms vary in expression between human tissues. As RNA-Seq datasets grow in size, it remains challenging to visualize isoform expression across multiple samples. Results: To help address this problem, we present Sashimi plots, a quantitative visualization of aligned RNA-Seq reads that enables quantitative comparison of exon usage across samples or experimental conditions. Sashimi plots can be made using the Broad Integrated Genome Viewer or with a stand-alone command line program. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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20. Transformation of the intestinal epithelium by the MSI2 RNA-binding protein.
- Author
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Wang, Shan, Li, Ning, Yousefi, Maryam, Nakauka-Ddamba, Angela, Li, Fan, Parada, Kimberly, Rao, Shilpa, Minuesa, Gerard, Katz, Yarden, Gregory, Brian D., Kharas, Michael G., Yu, Zhengquan, and Lengner, Christopher J.
- Published
- 2015
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21. Against storytelling of scientific results.
- Author
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Katz, Yarden
- Subjects
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RESEARCH , *STORYTELLING - Abstract
A letter to the editor is presented related to a research performed by researchers M. Krzywinski and A. Cairo on storytelling approach for scientific research.
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- 2013
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22. Higher Ed, Inc.
- Author
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Perry, Ruth and Katz, Yarden
- Subjects
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UNIVERSITIES & colleges , *CORPORATIONS , *COMMERCIAL buildings , *RESEARCH funding , *MARKETING - Abstract
How the university became a profit-generating cog in the corporate machine. [ABSTRACT FROM AUTHOR]
- Published
- 2018
23. Multiplexed activation of endogenous genes by CRISPR-on, an RNA-guided transcriptional activator system
- Author
-
Daniel B. Dadon, Albert W. Cheng, Thorold W. Theunissen, Rudolf Jaenisch, Chikdu S. Shivalila, Hui Yang, Linyu Shi, Sudharshan Rangarajan, Haoyi Wang, Yarden Katz, Massachusetts Institute of Technology. Computational and Systems Biology Program, Massachusetts Institute of Technology. Department of Biology, Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences, Whitehead Institute for Biomedical Research, Cheng, Albert W., Katz, Yarden, Shivalila, Chikdu Shakti, Dadon, Daniel Benjamin, and Jaenisch, Rudolf
- Subjects
Transcriptional Activation ,Recombinant Fusion Proteins ,Biology ,Mice ,03 medical and health sciences ,0302 clinical medicine ,Gene expression ,Animals ,Deoxyribonuclease I ,Humans ,Clustered Regularly Interspaced Short Palindromic Repeats ,Transgenes ,Cloning, Molecular ,Promoter Regions, Genetic ,Molecular Biology ,Gene ,transcription factor ,030304 developmental biology ,Regulation of gene expression ,0303 health sciences ,Reporter gene ,Cas9 ,HEK 293 cells ,Promoter ,Cell Biology ,Molecular biology ,3. Good health ,Cell biology ,Mice, Inbred C57BL ,Gene expression profiling ,artificial transcription factor ,HEK293 Cells ,CRISPR ,NIH 3T3 Cells ,gene expression ,Female ,Original Article ,synthetic biology ,030217 neurology & neurosurgery ,HeLa Cells ,RNA, Guide, Kinetoplastida ,Transcription Factors - Abstract
Technologies allowing for specific regulation of endogenous genes are valuable for the study of gene functions and have great potential in therapeutics. We created the CRISPR-on system, a two-component transcriptional activator consisting of a nuclease-dead Cas9 (dCas9) protein fused with a transcriptional activation domain and single guide RNAs (sgRNAs) with complementary sequence to gene promoters. We demonstrate that CRISPR-on can efficiently activate exogenous reporter genes in both human and mouse cells in a tunable manner. In addition, we show that robust reporter gene activation in vivo can be achieved by injecting the system components into mouse zygotes. Furthermore, we show that CRISPR-on can activate the endogenous IL1RN, SOX2, and OCT4 genes. The most efficient gene activation was achieved by clusters of 3-4 sgRNAs binding to the proximal promoters, suggesting their synergistic action in gene induction. Significantly, when sgRNAs targeting multiple genes were simultaneously introduced into cells, robust multiplexed endogenous gene activation was achieved. Genome-wide expression profiling demonstrated high specificity of the system., National Institutes of Health (U.S.) (Grant HD 045022), National Institutes of Health (U.S.) (Grant R37CA084198)
- Published
- 2013
24. Musashi proteins are post-transcriptional regulators of the epithelial-luminal cell state.
- Author
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Katz Y, Li F, Lambert NJ, Sokol ES, Tam WL, Cheng AW, Airoldi EM, Lengner CJ, Gupta PB, Yu Z, Jaenisch R, and Burge CB
- Subjects
- Alternative Splicing genetics, Animals, Base Sequence, Breast growth & development, Breast pathology, Breast Neoplasms genetics, Calcium-Binding Proteins metabolism, Cell Line, Tumor, Down-Regulation genetics, Epithelial Cells pathology, Epithelial-Mesenchymal Transition genetics, Female, Humans, Intercellular Signaling Peptides and Proteins metabolism, Jagged-1 Protein, Ligands, Membrane Proteins metabolism, Mice, Knockout, Models, Biological, Molecular Sequence Data, Morphogenesis, Neural Stem Cells metabolism, Nucleotide Motifs genetics, Protein Binding, Protein Biosynthesis, RNA-Binding Proteins metabolism, Receptors, Notch metabolism, Serrate-Jagged Proteins, Epithelial Cells metabolism, Gene Expression Regulation, Neoplastic, Nerve Tissue Proteins metabolism, Transcription, Genetic
- Abstract
The conserved Musashi (Msi) family of RNA binding proteins are expressed in stem/progenitor and cancer cells, but generally absent from differentiated cells, consistent with a role in cell state regulation. We found that Msi genes are rarely mutated but frequently overexpressed in human cancers and are associated with an epithelial-luminal cell state. Using ribosome profiling and RNA-seq analysis, we found that Msi proteins regulate translation of genes implicated in epithelial cell biology and epithelial-to-mesenchymal transition (EMT), and promote an epithelial splicing pattern. Overexpression of Msi proteins inhibited the translation of Jagged1, a factor required for EMT, and repressed EMT in cell culture and in mammary gland in vivo. Knockdown of Msis in epithelial cancer cells promoted loss of epithelial identity. Our results show that mammalian Msi proteins contribute to an epithelial gene expression program in neural and mammary cell types.
- Published
- 2014
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25. Single-cell analysis reveals that expression of nanog is biallelic and equally variable as that of other pluripotency factors in mouse ESCs.
- Author
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Faddah DA, Wang H, Cheng AW, Katz Y, Buganim Y, and Jaenisch R
- Subjects
- Animals, Cells, Cultured, Embryonic Stem Cells cytology, Flow Cytometry, Homeodomain Proteins genetics, In Situ Hybridization, Fluorescence, Mice, Mice, Inbred C57BL, Nanog Homeobox Protein, Pluripotent Stem Cells cytology, RNA, Messenger genetics, Red Fluorescent Protein, Biomarkers analysis, Embryonic Stem Cells metabolism, Green Fluorescent Proteins metabolism, Homeodomain Proteins metabolism, Luminescent Proteins metabolism, Pluripotent Stem Cells metabolism
- Abstract
The homeodomain transcription factor Nanog is a central part of the core pluripotency transcriptional network and plays a critical role in embryonic stem cell (ESC) self-renewal. Several reports have suggested that Nanog expression is allelically regulated and that transient downregulation of Nanog in a subset of pluripotent cells predisposes them toward differentiation. Using single-cell gene expression analyses combined with different reporters for the two alleles of Nanog, we show that Nanog is biallelically expressed in ESCs independently of culture condition. We also show that the overall variation in endogenous Nanog expression in ESCs is very similar to that of several other pluripotency markers. Our analysis suggests that reporter-based studies of gene expression in pluripotent cells can be significantly influenced by the gene-targeting strategy and genetic background employed., (Copyright © 2013 Elsevier Inc. All rights reserved.)
- Published
- 2013
- Full Text
- View/download PDF
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