Search

Your search keyword '"Kattleman K"' showing total 3 results
Start Over Author "Kattleman K" Language english
3 results on '"Kattleman K"'

3. Mechanisms of the antitumor responses and host-versus-graft reactions induced by recipient leukocyte infusions in mixed chimeras prepared with nonmyeloablative conditioning: a critical role for recipient CD4+ T cells and recipient leukocyte infusion-derived IFN-gamma-producing CD8+ T cells.

Author

Rubio MT, Saito TI, Kattleman K, Zhao G, Buchli J, and Sykes M

Subjects
Animals, CD8-Positive T-Lymphocytes metabolism, CD8-Positive T-Lymphocytes transplantation, Cell Line, Tumor, Cytotoxicity, Immunologic genetics, Down-Regulation genetics, Down-Regulation immunology, Female, Graft Rejection genetics, Graft Rejection immunology, Host vs Graft Reaction genetics, Interferon-gamma antagonists & inhibitors, Interferon-gamma deficiency, Leukemia, B-Cell genetics, Leukemia, B-Cell therapy, Lymphocyte Activation genetics, Lymphocyte Depletion, Lymphoma, B-Cell genetics, Lymphoma, B-Cell immunology, Lymphoma, B-Cell therapy, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Knockout, CD4-Positive T-Lymphocytes immunology, CD8-Positive T-Lymphocytes immunology, Host vs Graft Reaction immunology, Interferon-gamma biosynthesis, Leukemia, B-Cell immunology, Leukocyte Transfusion methods, Radiation Chimera immunology, Transplantation Conditioning methods
Abstract

Surprisingly, antitumor responses can occur in patients who reject donor grafts following nonmyeloablative hemopoietic cell transplantation. In murine mixed chimeras prepared with nonmyeloablative conditioning, we previously showed that recipient leukocyte infusions (RLI) induced loss of donor chimerism, IFN-gamma production, and antitumor responses against host-type tumors. However, the mechanisms behind this phenomenon remain to be determined. We now demonstrate that the effects of RLI are mediated by distinct and complex mechanisms. Donor marrow rejection is induced by RLI-derived alloactivated T cells, which activate non-RLI-derived, recipient IFN-gamma-producing cells. RLI-derived CD8 T cells induce the production of IFN-gamma by both RLI and non-RLI-derived recipient cells. The antitumor responses of RLI involve mainly RLI-derived IFN-gamma-producing CD8 T cells and recipient-derived CD4 T cells and do not involve donor T cells. The pathways of donor marrow and tumor rejection lead to the development of tumor-specific cell-mediated cytotoxic responses that are not due to bystander killing by alloreactive T cells.

Published
2005
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results