93 results on '"Kagawa E"'
Search Results
2. Comparison of mineralogical composition of asteroid Ryugu samples returned by the Hayabusa2 mission and antarctic micrometeorites (AMMs)
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Bejach, L., Engrand, C., Duprat, J., Dartois, E., Mathurin, J., Dazzi, A., Deniset-Besseau, A., Rividi, N., Sandt, C., Borondics, F., Troadec, David, Nakamura, T., Morita, T., Kikuiri, M., Amano, K., Kagawa, E., Yabuta, H., Noguchi, T., Yurimoto, H., Okazaki, R., Naraoka, H., Sakamoto, K., Tachibana, S., Watanabe, S., Tsuda, Y., Laboratoire de Physique des 2 Infinis Irène Joliot-Curie (IJCLab), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Institut des Sciences Moléculaires d'Orsay (ISMO), Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Plateforme Camparis - Plateforme analytique MEN (Microanalyses en sciences de l’Environnement) [Paris], Observatoire des sciences de l'univers Ecce Terra [Paris] (OSU ECCE TERRA), École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), Université catholique de Lille (UCL)-Université catholique de Lille (UCL), Centrale de Micro Nano Fabrication - IEMN (CMNF - IEMN), Université catholique de Lille (UCL)-Université catholique de Lille (UCL)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), This work was supported by CNES (MIAMI-HY2), the French ANR (COMETOR, ANR-18-CE31-0011) as well as INSU (PNP, PCMI), IN2P3, DIM-ACAV+ (Region Ile de France), CNRS. We are grateful to the French and Italian polar institutes IPEV and PNRA, for their financial and logistic support to the micrometeorites collection at the vicinity of the CONCORDIA station (Dome C)., Renatech Network, CMNF, and ANR-18-CE31-0011,COMETOR,Origine de la poussière cométaire(2018)
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[SPI]Engineering Sciences [physics] - Abstract
International audience
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- 2022
3. Role of medications in symptomatic hyperkalemia
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Kurisu, S., Inoue, I., Kawagoe, T., Ishihara, M., Shimatani, Y., Nakama, Y., Maruhashi, T., Kagawa, E., Dai, K., and Aokage, T.
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- 2007
4. Ischaemic preconditioning effect of prodromal angina pectoris is lost in patients with prior myocardial infarction
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Ishihara, M, Inoue, I, Kawagoe, T, Shimatani, Y, Kurisu, S, Hata, T, Nakama, Y, Kijima, Y, and Kagawa, E
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- 2006
5. ANALYSIS OF "STONE" SAMPLES FROM C-TYPE ASTEROID RYUGU.
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Nakamura, T., Matsumoto, M., Amano, K., Enokido, Y., Zolensky, M., Mikouchi, T., Genda, H., Tanaka, S., Zolotov, M. Y., Kurosawa, K., Wakita, S., Hyodo, R., Nagano, H., Nakashima, D., Takahashi, Y., Fujioka, Y., Kikuiri, M., Kagawa, E., Matsuoka, M., and Brearley, A. J.
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FLUID inclusions ,MAGNETIC measurements ,ASTEROIDS ,PETROLOGY ,MINERALOGY ,CALCIUM silicates ,OLIVINE - Abstract
Introduction: Asa part of the Hayabusa2 initial analysis [1], we analyzed eighteen Ryugu "stone" samples of 1 ~ 8 mm in size: seven stones from the 1
st touch down site and eleven from the 2nd touch down site. Ryugu stones were analyzed first using X-rays. UV, visible, near-infrared mid-infrared, and mutes probes for surface reflectance spectra, internal 3D structure and element distribution [2], crystal structures, and bulk composition of light elements such as C, N, and 0. Measurements for magnetic, thermal, and physical properties mine some stones were also performed. TOF-SDIS analysis of fluid inclusions is being continued [3]. Small particles separated from some stones were ana-lyzed by IR-CT [4]. Based on 3D-CT images of individual stones, objects of interests were identified, separated by pFIE cutting, and exposed by polishing on the surface of epoxy disks. FE.EPMAJFE-SEM analysis was made on ~40 polished epoxy disks for chemical composition and textural observation [5-9]. FIB sections and small (~15 μ in diameter) fragments were separated from the polished surface and analyzed by rod, S170.1, XRF, and nano-CT. Results and discussion: Eighteen stone 2D and 3D images indicate that Ryon samples are breccias of small fragments (< ~1mm in size) of basically CI chondrite mineralogy [10]. Most of the fragments are heavily altered and consists mainly of phyllosilicates. carbonates (dolomite and brannerite), Fe sulfides and oxides, and phosphates (F-bearing hydroxyapatite); this mineralogy we call the major lithology. The mineralogy of the fragments of the major lithology shows some diversity. the abundance and shape of carbonates and phosphates differ among fragments. On the other band, some fragments in many stones are less altered and contain anhydrous silicates such as olivine and low-Ca pyroxene of typically Mr#>97 but down to Mg#~50, which we call the less-altered litbology. In the less-altered lithology, the abundance of olivine and pyroxene differs between fragments and some fragments contain them up to - 10 volti. Therefore, fragments with the less-altered lithology can be classified as CL-type thou-drite material. Most, but not all. fragments with the less-altered lithology contain only calcite as carbonate, phosphides (FeNi)3 P and (Fe, Ni)2 P instead of apatite. and poorly-crystallized amorphous silicates. Small (<20μm in size) type-I barred and porphyritic chondrules and CAI with spinel+hibonite-tennskite assemblages also occur. GaIS-ble ob-jects are abundant in the least-altered fragments. In summary, mineralogical and physical properties of Ryugu samples reveal incipient to advanced aqueous alteration in its parent asteroid. [ABSTRACT FROM AUTHOR]- Published
- 2022
6. OLIVINE MINERALOGY OF ASTEROID RYUGU SAMPLES AND CI CHONDRITES: FURTHER EVIDENCE FOR THEIR COMMON ORIGIN.
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Mikouchi, T., Yoshida, H., Nakamura, T., Zolensky, M. E., Nakashima, D., Hagiya, K., Kikuiri, M., Morita, T., Amano, K., Kagawa, E., Yurimoto, H., Noguchi, T., Okazaki, R., Yabuta, H., Naraoka, H., Sakamoto, K., Tachibana, S., Watanabe, S., and Tsuda, Y.
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OLIVINE ,CHONDRITES ,MINERALOGY ,ASTEROIDS ,PHYLLOSILICATES ,BRECCIA - Abstract
Introduction: Initial analysis of asteroid Ryugu samples has revealed that they were mm-μm scale breccia mostly composed of aqueously altered phases (e.g., Mg-Fe phyllosilicates, carbonates) and showed remarkable similarities to CI chondrites in mineralogy and chemistry [e.g., 1,2]. Our detailed analysis of Ryugu samples has detected small amounts (<<1 vol.%) of unaltered silicates that would escape severe aqueous alteration [3]. Olivine is the most abundant (>90 vol%) phase among such unaltered silicates. Although most Ryugu olivine grains are smaller than 5 μm, they bear important information about the precursors of the parent Ryugu asteroid. In this abstract we report additional results of olivine mineralogical study of Ryugu samples, and especially compare with olivine grains in CI chondrites (Ivuna and Orgueil) to further discuss their relationship and possible common origin. Samples and Methods: Polished sections of A0026, A0055, A0063, A0106, C0002, C0023, C0025, C0033, C0040, C0046, C0055, C0076 and C0103 were analyzed using JEOL JXA-8530F FE-EPMA at Univ. of Tokyo. The quantitative analysis was performed at 12 kV accelerating voltage / 30 nA beam current (counting times at peaks: 30 sec), allowing us to obtain accurate compositions even from ~1 μm olivine grain. For comparison, polished sections of Ivuna and Orgueil with similar size to Ryugu samples (a few mm in size) were analyzed by the same method. Results: Olivine grains are present only in weakly-altered lithologies in Ryugu samples [e.g., 2]. So far we have not found olivine from Chamber A samples. Although we acquired compositions from ~200 additional olivine grains this time, the obtained compositions are basically identical to what we have already obtained [3]. Olivine compositions are clustered at Fo99 and extends to Fo44. Most olivine has 0.0-0.7 wt% MnO, and rare (<5%) LIME olivine (MnO/FeO>1 in wt%) grains are present. There is a positive correlation between Mn and Cr in olivine (MnO: 0.0-1.5 wt% vs. Cr2O3: 0.0-0.7 wt%) (Fig. 1). Most olivine grains are Ca-poor (CaO: <0.1 wt%). The comparative analysis of Ivuna and Orgueil has shown that both samples are similarly brecciated to Ryugu samples in size and mineralogy, and we found that weakly-altered lithologies contain tiny (mostly <5 μm) olivine grains. The size, texture, abundance and mineral compositions of olivine in Ivuna and Orgueil are strikingly similar to those of Ryugu olivines both in major and minor elemental compositions (Fig. 1). Discussion and Conclusion: We found identical olivine mineralogy between Ryugu samples and CI chondrites, further supporting that Ryugu samples are similar to CI chondrites [e.g., 1,2]. Although olivine has been reported in CI chondrites, the reported size is larger than 50 μm in many cases [e.g., 4]. Smaller olivine grains (<5 μm) as found in this study have not been well documented except few cases [e.g., 5]. Because the reported CI olivine composition is slightly different from our CI chondrite data [e.g., 4], there would be multiple origins for olivine in CI chondrites and Ryugu samples. In any case, the presence of small olivine grains (<5 μm) found in Ryugu and CI chondrites is important because such tiny olivine could be common precursors of these chondritic materials. [ABSTRACT FROM AUTHOR]
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- 2022
7. VISIBLE-IR SPECTROSCOPIC DIVERSITY OF RYUGU COARSE GRAINS AND COMPARISON TO SPECTRAL PROPERTIES OF CARBONACEOUS CHONDRITES.
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Amano, K., Matsuoka, M., Nakamura, T., Kagawa, E., Fujioka, Y., Potin, S. M., Hiroi, T., Tatsumi, E., Milliken, R. E., Brunetto, R., Beck, P., Takahashi, Y., Kawai, T., Yamashita, S., Uesugi, M., Morita, T., Kikuiri, M., Yurimoto, H., Noguchi, T., and Okazaki, R.
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VISIBLE spectra ,CHONDRITES ,COMPUTED tomography ,ABSORPTION spectra ,OXIDATION of water ,REFLECTANCE spectroscopy - Abstract
Introduction: The spacecraft Hayabusa2 explored C-type asteroid Ryugu and brought back representative samples of Ryugu to the Earth in 2020 [1]. We performed reflectance spectroscopy of Ryugu samples to investigate (1) spectral diversity among Ryugu samples and (2) similarities and differences between Ryugu samples and carbonaceous chondrites. These results can also be applied to spectroscopic observations performed by the spacecraft [2,3]. Sample and Analysis: We measured Visible-infrared (Vis-IR, 0.4-18 μm in wavelength) reflectance spectra of 6 and 8 coarse grains (> 1mm in size) collected from the first and second touchdown sites, respectively, and some carbonaceous chondrites. Samples were put into an air-tight cell sealed with a CaF2 or ZnSe window together with reflectance standards. All the sample handling was performed in a pure-N2 -purged glove-box to avoid atmospheric alteration of the samples. Petrological and mineralogical characterization of the samples including synchrotron X-ray computed tomography and X-ray diffraction analysis was done by other analysis groups in the Hayabusa2 initial analysis "Stone" team [e.g., 4]. IR signature of Ryugu samples compared to hydrated chondrites: All the Ryugu coarse grains have an absorption band at ~2.71 μm attributed to Mg-rich phyllosilicates and a reflectance maximum (Reststrahlen band) at ~9.8 μm suggesting saponite-bearing phyllosilicate composition. These signatures of phyllosilicates of Ryugu are similar to those of CI chondrites, which is consistent with mineralogical observations of Ryugu samples [e.g., 4]. Ryugu sample spectra show absorption features due to aliphatic compounds (3.4 μm), carbonates (e.g., ~3.4, 3.95 μm), and some samples show an absorption feature at 5.8 μm probably due to carbonyl compounds [5]. Ryugu samples show a sharper 2.7 μm band than CIs, suggesting that they contain little molecular water compared to CIs. Sulfate features are not observed in Mid-IR reflectance spectra of Ryugu unlike CIs [e.g., 6]. Tagish Lake C2-ungrouped chondrite also shows an absorption band at ~2.7 μm and Reststrahlen band at ~9.8 μm. However, IR spectral features due to carbonates are more significant in the spectra of Tagish Lake than those of Ryugu as seen in absorption bands around ~3.4 μm and a reflectance maximum at 11.2 μm [7]. CM chondrites also consist mainly of hydrated minerals, however, their spectral shapes around ~3 μm and ~10 μm are different from those of Ryugu most likely due to the different phyllosilicate composition. Vis reflectance spectra of Ryugu samples: Ryugu coarse grains have ~2-4% of reflectance in the v-band (0.55 μm) at the phase angle of 30 °, which is roughly consistent with those of hydrated carbonaceous chondrites (CI, CM, Tagish Lake, and Tarda). The reflectance spectra of CO and CV chondrites, which are dominated by anhydrous minerals and more chondrule-rich, are brighter than those of Ryugu samples. The IR spectra suggest the compositional link between Ryugu and CI chondrites, however, Vis reflectance spectra of Ryugu are not similar to CI chondrites. Low reflectance Vis spectra without a UV drop (a sudden reflectance decrease towards UV wavelengths) of Ryugu samples are not similar to unheated Orgueil but similar to Orgueil samples heated at 300-400 °C for 50 hours (or longer) in reduced conditions [8]. The causes of differences between Vis spectra of Ryugu and unheated CIs may be explained by: (1) atmospheric alteration of CIs (e.g., oxidation and water adsorption of CIs [e.g., 9]), (2) different organic composition, and (3) gentle heating experienced by Ryugu. Vis reflectance spectra of Ryugu particles show some diversity of properties (reflectance, spectral slope, and overall shapes), while IR spectra are consistent among samples. This suggests that the spectral diversity of Ryugu samples are originated from physical properties or orientations of sample surfaces rather than the compositional differences among individual particles. [ABSTRACT FROM AUTHOR]
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- 2022
8. SYNCHROTRON BASED TRACE ELEMENT ANALYSES OF A MAGNETITE VEIN CROSS CUTTING A MM-SIZED RYUGU ROCK FRAGMENT.
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Brenker, F. E., Bazi, B., DePauw, E., Di Michiel, M., Falkenberg, G., Garrevoet, J., Lindner, M., Nakamura, T., Tack, P., Tkalcec, B., Vekemans, B., Uesugi, M., Matsumoto, M., Nakashima, D., Fujioka, Y., Morita, T., Kikuiri, M., Amano, K., Kagawa, E., and Yurimoto, H.
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MAGNETITE ,TRACE element analysis ,COMPUTED tomography ,SMALL area statistics ,VEINS ,X-ray fluorescence - Abstract
Introduction: The successful probing, return and curation of asteroid Ryugu provides pristine sample material from the surface and subsurface of this C-type asteroid. The sampled material of the Hayabusa2 mission includes many coarse-grained fragments [1, 2]. In order to obtain the highest level of scientific output the initial study included several non-invasive and non-destructive analytical techniques. Synchrotron X-ray fluorescence computed tomography (SXRF-CT) [e.g. 3] is an ideal non-invasive analytical technique to achieve detailed in depth structural and chemical information and was applied to several mm-sized rock fragments of the asteroid Ryugu from both, surface and sub-surface samples. Here we present the first dataset on coarse grain C0033, collected at the second touchdown site. Methods: X-ray fluorescence spectroscopy experiments were performed at the P06 beamline of PETRA III (DESY, Hamburg, Germany) and at the ID15A beamline of the ESRF (Grenoble, France). The excitation energy E0 was 20.5 keV and 90 keV respectively, using Si(111) monochromator optics. The Kirkpatrick-Baez (KB) mirrorbased X-ray beam focusing provided a 0.2×0.24 µm² beam spot size at sample position during the P06 experiments, and a 0.5×0.5 µm² beam spot at sample position for the ID15A experiments. High-Energy SXRF: Every detailed SXRF analysis was started with a chemical 2D overview projection of the full volume of the mm-sized rock fragment. In case of sample C0033 an Fe-rich vein was identified. Several crosssection CT scans were performed during our subsequent study, one exactly at the height where the Fe-rich vein was observed. The cross section indicates the presence of REE-rich phases throughout the vein and confirms the vein-like nature of the Fe-enriched area. Lower-Energy SXRF: For further studies a polished section (~100 µm thick) of grain C0033 was prepared exactly at the height of the magnetite vein and was then further analysed at lower X-ray energy (20.5 keV) at PETRA III beamline P06. The Fe distribution found confirms the existence of a magnetite-rich vein. Ca and Y element maps indicate the presence of multiple apatite grains closely related to the vein. Quantification: The SXRF measurements not only provide element distribution maps but can also be quantified. In order to get better statistics small area maps and point analyses were performed. The resulting CI normalized trace element concentrations of magnetite and apatite grains located within the magnetite vein observed in C0033 show values close to CI bulk composition. All quantified measurements were acquired at PETRA III P06 beamline applying a primary beam energy of 20.5 keV. Discussion and Conclusion: The detailed SXRF study of mm-sized Ryugu rock fragments enabled the identification and localization of unique sample characteristics like the magnetite-apatite vein found in grain C0033. Veins crosscutting the sample material are compelling evidence for intense hydrous alteration on the parent body. The widespread occurrence of sulphate veins found in most CI chondrites was first interpreted as evidence for late stage lowtemperature alteration on the asteroid [e.g. 5], but later clear proof was found for the terrestrial formation of these features in almost all samples [6]. The study of rock samples sampled on the sub-surface of asteroid Ryugu now for the first time enables to study hydrous alteration processes without any terrestrial alteration. Our study shows compelling evidence for the existence of low temperature hydrous alteration veins on asteroid Ryugu. Surprisingly, the vein consists of a mixture of mostly magnetite with apatite, which is in contrast to the observation of carbonate veins found on the surface of asteroid Bennu [7]. [ABSTRACT FROM AUTHOR]
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- 2022
9. ACQUEOUS ALTERATION PROBED BY MUTLI-ASSEMBLY AND 3D HETEROGENEITY IN SMALL RYUGU FRAGMENTS.
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Dionnet, Z., Aléon-Toppani, A., Brunetto, R., Rubino, S., Nakamura, T., Baklouti, D., Djouadi, Z., Lantz, C., Mivumbi, O., Borondics, F., Héripré, E., Troadec, D., Tsuchiyama, A., Matsuno, J., Matsumoto, M., Morita, T., Kikuiri, M., Amano, K., Kagawa, E., and Yurimoto, H.
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CARBONACEOUS chondrites (Meteorites) ,FOCUSED ion beams ,INFRARED imaging ,COMPUTED tomography ,HETEROGENEITY ,STONE - Abstract
Introduction: In December 2020, the Hayabusa2 reentry capsule returned 5.4 g of material from the asteroid Ryugu. A fraction of the collected material was then examined by Initial Analysis Teams. As a part of the Mineralogy / Petrology STONE team, we received ~30 small fragments to study the 3D heterogeneity and the assembly of the different phases. Material and methods: In this study, we will present the results of a muti-analytical sequence applied to nine micrometric Ryugu fragments (ranging from 30 to 80 µm in size), coming from 3 bigger millimetric grains (A0064, C0046, and C0002). These fragments were welded with platinum on metallic needles using FIB (Focus Ion Beam) microscopes in Saclay and Lille [1]. Then, we analyzed these fragments using an IR micro-tomography setup available at the SMIS beamline of the SOLEIL synchrotron (France). Multiple configurations were used: analyses in transmission by Infrared Computed Tomography [2] (IR-CT) and analyses in reflectance by Infrared Surface Imaging [3] (IRSI). Regions of interest with peculiar spectral signatures were identified on the 3D volume and 3-µm thin-slices (~ 15 x 20 x 3 µm³) around these regions were extracted using FIB. They were finally analyzed in 2D with high-resolution IR imaging and SEM-EDX. Average composition: We will present the average IR spectra in the 2.5 - 12.5 µm range both in reflectance and transmission of the 9 small studied fragments. Several grains showed IR signatures at ~ 2.7 µm, 3.0-3.1 µm, 3.4 µm, and 3.9 µm, in a good agreement with the bands identified by NIRS3 or by MicrOmega in the JAXA curation facility [4,5], plus several mid-IR signatures of great interest, such as bands attributed to Si-O stretching in phyllosilicates, and C=O stretching in organics and carbonates. In general, the 2.7 µm feature observed in our data exhibits similar maximum position but is deeper to the one observed with NIRS3. However, we notice a variability of the composition between the 9 fragments, for instance in the intensity of the 2.7 and 3.4 µm features. Study of heterogeneity: The small fragment C0002-FO019, exhibits two regions with very different IR signatures. The difference in the position and the shape of the SiO feature could sign different lithologies affected by various degrees of aqueous alteration. In particular, some spectra show a shoulder at ~ 998 cm-1 which could be due to anhydrous silicate related to a less-altered lithology [6]. The origin of the variation of the 10 µm band (chemical composition, or structural diversity of the mineral) will be discussed. A correlation with the 2.7 µm band will also be presented. Complementary measurements performed with SEM-EDX to better constrain the mineralogy of the surface of the extracted thin-slices will be presented and we will discuss the structural diversity at the scale of ~100 nm. [ABSTRACT FROM AUTHOR]
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- 2022
10. Automatic Generation of Configuration Manuals for Open-Source Software.
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Murakami, Y., Kagawa, E., and Funabiki, N.
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- 2011
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11. Should we emergently revascularize occluded coronaries for cardiac arrest?: rapid-response extracorporeal membrane oxygenation and intra-arrest percutaneous coronary intervention.
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Kagawa E, Dote K, Kato M, Sasaki S, Nakano Y, Kajikawa M, Higashi A, Itakura K, Sera A, Inoue I, Kawagoe T, Ishihara M, Shimatani Y, and Kurisu S
- Abstract
BACKGROUND: Extracorporeal membrane oxygenation (ECMO) and percutaneous coronary intervention (PCI) may be useful in cardiopulmonary resuscitation. However, little is known about the combination of ECMO and intra-arrest PCI. This study investigated the efficacy of rapid-response ECMO and intra-arrest PCI in patients with cardiac arrest complicated by acute coronary syndrome who were unresponsive to conventional cardiopulmonary resuscitation. METHODS AND RESULTS: This multicenter cohort study was conducted with the use of the database of ECMO in Hiroshima City, Japan. Between January 2004 and May 2011, rapid-response ECMO was performed in 86 patients with acute coronary syndrome who were unresponsive to conventional CPR. The median age of the study patients was 63 years, and 81% were male. Emergency coronary angiography was performed in 81 patients (94%), and intra-arrest PCI was performed in 61 patients (71%). The rates of return of spontaneous heartbeat, 30-day survival, and favorable neurological outcomes were 88%, 29%, and 24%, respectively. All of the patients who received intra-arrest PCI achieved return of spontaneous heartbeat. In patients who survived up to day 30, the rate of out-of-hospital cardiac arrest was lower (58% versus 28%; P=0.01), the intra-arrest PCI was higher (88% versus 70%; P=0.04), and the time interval from collapse to the initiation of ECMO was shorter (40 [25-51] versus 54 minutes [34-74 minutes]; P=0.002). CONCLUSIONS: Rapid-response ECMO plus intra-arrest PCI is feasible and associated with improved outcomes in patients who are unresponsive to conventional cardiopulmonary resuscitation. On the basis of these findings, randomized studies of intra-arrest PCI are needed. [ABSTRACT FROM AUTHOR]
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- 2012
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12. Prevalence of incidental coronary artery disease in tako-tsubo cardiomyopathy.
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Kurisu S, Inoue I, Kawagoe T, Ishihara M, Shimatani Y, Nakama Y, Maruhashi T, Kagawa E, Dai K, Matsushita J, Ikenaga H, Kurisu, Satoshi, Inoue, Ichiro, Kawagoe, Takuji, Ishihara, Masaharu, Shimatani, Yuji, Nakama, Yasuharu, Maruhashi, Tatsuya, Kagawa, Eisuke, and Dai, Kazuoki
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- 2009
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13. Next Generation of High Temperature Structural Intermetallic Compounds.
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Cells, Pedro B., Ishizaki, K., Kagawa, E., and Ishikawa, J.
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- 1992
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14. Predicting elevated natriuretic peptide in chest radiography: emerging utilization gap for artificial intelligence.
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Kagawa E, Kato M, Oda N, Kunita E, Nagai M, Yamane A, Matsui S, Yoshitomi Y, Shimajiri H, Hirokawa T, Ishida S, Kurimoto G, and Dote K
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Aims: This study assessed an artificial intelligence (AI) model's performance in predicting elevated brain natriuretic peptide (BNP) levels from chest radiograms and its effect on diagnostic performance among healthcare professionals., Methods and Results: Patients who underwent chest radiography and BNP testing on the same day were included. Data were sourced from two hospitals: one for model development, and the other for external testing. Two final ensemble models were developed to predict elevated BNP levels of ≥ 200 pg/mL and ≥ 100 pg/mL, respectively. Humans were evaluated to predict elevated BNP levels, followed by the same test, referring to the AI model's predictions. A total of 8390 images were collected for model creation, and 1713 images, for tests. The AI model achieved an accuracy of 0.855, precision of 0.873, sensitivity of 0.827, specificity of 0.882, f1 score of 0.850, and receiver-operating-characteristics area-under-curve of 0.929. The accuracy of the testing by 35 participants significantly improved from 0.708 ± 0.049 to 0.829 ± 0.069 ( P < 0.001) with the AI assistance (an accuracy of 0.920). Without the AI assistance, the accuracy of the veterans in the medical career was higher than that of early-career professionals (0.728 ± 0.051 vs. 0.692 ± 0.042, P = 0.030); however, with the AI assistance, the accuracy of the early-career professionals was rather higher than that of the veterans (0.851 ± 0.074 vs. 0.803 ± 0.054, P = 0.033)., Conclusion: The AI model can predict elevated BNP levels from chest radiograms and has the potential to improve human performance. The gap in utilizing new tools represents one of the emerging issues., (© The Author(s) 2024. Published by Oxford University Press on behalf of the European Society of Cardiology.)
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- 2024
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15. Nonmagnetic framboid and associated iron nanoparticles with a space-weathered feature from asteroid Ryugu.
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Kimura Y, Kato T, Anada S, Yoshida R, Yamamoto K, Tanigaki T, Akashi T, Kasai H, Kurosawa K, Nakamura T, Noguchi T, Sato M, Matsumoto T, Morita T, Kikuiri M, Amano K, Kagawa E, Yada T, Nishimura M, Nakato A, Miyazaki A, Yogata K, Abe M, Okada T, Usui T, Yoshikawa M, Saiki T, Tanaka S, Terui F, Nakazawa S, Yurimoto H, Okazaki R, Yabuta H, Naraoka H, Sakamoto K, Watanabe SI, Tsuda Y, and Tachibana S
- Abstract
Extraterrestrial minerals on the surface of airless Solar System bodies undergo gradual alteration processes known as space weathering over long periods of time. The signatures of space weathering help us understand the phenomena occurring in the Solar System. However, meteorites rarely retain the signatures, making it impossible to study the space weathering processes precisely. Here, we examine samples retrieved from the asteroid Ryugu by the Hayabusa2 spacecraft and discover the presence of nonmagnetic framboids through electron holography measurements that can visualize magnetic flux. Magnetite particles, which normally provide a record of the nebular magnetic field, have lost their magnetic properties by reduction via a high-velocity (>5 km s
-1 ) impact of a micrometeoroid with a diameter ranging from 2 to 20 μm after destruction of the parent body of Ryugu. Around these particles, thousands of metallic-iron nanoparticles with a vortex magnetic domain structure, which could have recorded a magnetic field in the impact event, are found. Through measuring the remanent magnetization of the iron nanoparticles, future studies are expected to elucidate the nature of the nebular/interplanetary magnetic fields after the termination of aqueous alteration in an asteroid., (© 2024. The Author(s).)- Published
- 2024
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16. Reassigning CI chondrite parent bodies based on reflectance spectroscopy of samples from carbonaceous asteroid Ryugu and meteorites.
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Amano K, Matsuoka M, Nakamura T, Kagawa E, Fujioka Y, Potin SM, Hiroi T, Tatsumi E, Milliken RE, Quirico E, Beck P, Brunetto R, Uesugi M, Takahashi Y, Kawai T, Yamashita S, Enokido Y, Wada T, Furukawa Y, Zolensky ME, Takir D, Domingue DL, Jaramillo-Correa C, Vilas F, Hendrix AR, Kikuiri M, Morita T, Yurimoto H, Noguchi T, Okazaki R, Yabuta H, Naraoka H, Sakamoto K, Tachibana S, Yada T, Nishimura M, Nakato A, Miyazaki A, Yogata K, Abe M, Okada T, Usui T, Yoshikawa M, Saiki T, Tanaka S, Terui F, Nakazawa S, Watanabe SI, and Tsuda Y
- Abstract
The carbonaceous asteroid Ryugu has been explored by the Hayabusa2 spacecraft to elucidate the actual nature of hydrous asteroids. Laboratory analyses revealed that the samples from Ryugu are comparable to unheated CI carbonaceous chondrites; however, reflectance spectra of Ryugu samples and CIs do not coincide. Here, we demonstrate that Ryugu sample spectra are reproduced by heating Orgueil CI chondrite at 300°C under reducing conditions, which caused dehydration of terrestrial weathering products and reduction of iron in phyllosilicates. Terrestrial weathering of CIs accounts for the spectral differences between Ryugu sample and CIs, which is more severe than space weathering that likely explains those between asteroid Ryugu and the collected samples. Previous assignments of CI chondrite parent bodies, i.e., chemically most primitive objects in the solar system, are based on the spectra of CI chondrites. This study indicates that actual spectra of CI parent bodies are much darker and flatter at ultraviolet to visible wavelengths than the spectra of CI chondrites.
- Published
- 2023
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17. Visualization of nanoscale magnetic domain states in the asteroid Ryugu.
- Author
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Kimura Y, Kato T, Tanigaki T, Akashi T, Kasai H, Anada S, Yoshida R, Yamamoto K, Nakamura T, Sato M, Amano K, Kikuiri M, Morita T, Kagawa E, Yada T, Nishimura M, Nakato A, Miyazaki A, Yogata K, Abe M, Okada T, Usui T, Yoshikawa M, Saiki T, Tanaka S, Terui F, Nakazawa S, Yurimoto H, Noguchi T, Okazaki R, Yabuta H, Naraoka H, Sakamoto K, Watanabe SI, Tsuda Y, and Tachibana S
- Abstract
In the samples collected from the asteroid Ryugu, magnetite displays natural remanent magnetization due to nebular magnetic field, whereas contemporaneously grown iron sulfide does not display stable remanent magnetization. To clarify this counterintuitive feature, we observed their nanoscale magnetic domain structures using electron holography and found that framboidal magnetites have an external magnetic field of 300 A m
-1 , similar to the bulk value, and its magnetic stability was enhanced by interactions with neighboring magnetites, permitting a disk magnetic field to be recorded. Micrometer-sized pyrrhotite showed a multidomain magnetic structure that was unable to retain natural remanent magnetization over a long time due to short relaxation time of magnetic-domain-wall movement, whereas submicron-sized sulfides formed a nonmagnetic phase. These results show that both magnetite and sulfide could have formed simultaneously during the aqueous alteration in the parent body of the asteroid Ryugu., (© 2023. Springer Nature Limited.)- Published
- 2023
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18. Formation and evolution of carbonaceous asteroid Ryugu: Direct evidence from returned samples.
- Author
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Nakamura T, Matsumoto M, Amano K, Enokido Y, Zolensky ME, Mikouchi T, Genda H, Tanaka S, Zolotov MY, Kurosawa K, Wakita S, Hyodo R, Nagano H, Nakashima D, Takahashi Y, Fujioka Y, Kikuiri M, Kagawa E, Matsuoka M, Brearley AJ, Tsuchiyama A, Uesugi M, Matsuno J, Kimura Y, Sato M, Milliken RE, Tatsumi E, Sugita S, Hiroi T, Kitazato K, Brownlee D, Joswiak DJ, Takahashi M, Ninomiya K, Takahashi T, Osawa T, Terada K, Brenker FE, Tkalcec BJ, Vincze L, Brunetto R, Aléon-Toppani A, Chan QHS, Roskosz M, Viennet JC, Beck P, Alp EE, Michikami T, Nagaashi Y, Tsuji T, Ino Y, Martinez J, Han J, Dolocan A, Bodnar RJ, Tanaka M, Yoshida H, Sugiyama K, King AJ, Fukushi K, Suga H, Yamashita S, Kawai T, Inoue K, Nakato A, Noguchi T, Vilas F, Hendrix AR, Jaramillo-Correa C, Domingue DL, Dominguez G, Gainsforth Z, Engrand C, Duprat J, Russell SS, Bonato E, Ma C, Kawamoto T, Wada T, Watanabe S, Endo R, Enju S, Riu L, Rubino S, Tack P, Takeshita S, Takeichi Y, Takeuchi A, Takigawa A, Takir D, Tanigaki T, Taniguchi A, Tsukamoto K, Yagi T, Yamada S, Yamamoto K, Yamashita Y, Yasutake M, Uesugi K, Umegaki I, Chiu I, Ishizaki T, Okumura S, Palomba E, Pilorget C, Potin SM, Alasli A, Anada S, Araki Y, Sakatani N, Schultz C, Sekizawa O, Sitzman SD, Sugiura K, Sun M, Dartois E, De Pauw E, Dionnet Z, Djouadi Z, Falkenberg G, Fujita R, Fukuma T, Gearba IR, Hagiya K, Hu MY, Kato T, Kawamura T, Kimura M, Kubo MK, Langenhorst F, Lantz C, Lavina B, Lindner M, Zhao J, Vekemans B, Baklouti D, Bazi B, Borondics F, Nagasawa S, Nishiyama G, Nitta K, Mathurin J, Matsumoto T, Mitsukawa I, Miura H, Miyake A, Miyake Y, Yurimoto H, Okazaki R, Yabuta H, Naraoka H, Sakamoto K, Tachibana S, Connolly HC Jr, Lauretta DS, Yoshitake M, Yoshikawa M, Yoshikawa K, Yoshihara K, Yokota Y, Yogata K, Yano H, Yamamoto Y, Yamamoto D, Yamada M, Yamada T, Yada T, Wada K, Usui T, Tsukizaki R, Terui F, Takeuchi H, Takei Y, Iwamae A, Soejima H, Shirai K, Shimaki Y, Senshu H, Sawada H, Saiki T, Ozaki M, Ono G, Okada T, Ogawa N, Ogawa K, Noguchi R, Noda H, Nishimura M, Namiki N, Nakazawa S, Morota T, Miyazaki A, Miura A, Mimasu Y, Matsumoto K, Kumagai K, Kouyama T, Kikuchi S, Kawahara K, Kameda S, Iwata T, Ishihara Y, Ishiguro M, Ikeda H, Hosoda S, Honda R, Honda C, Hitomi Y, Hirata N, Hirata N, Hayashi T, Hayakawa M, Hatakeda K, Furuya S, Fukai R, Fujii A, Cho Y, Arakawa M, Abe M, Watanabe S, and Tsuda Y
- Abstract
Samples of the carbonaceous asteroid Ryugu were brought to Earth by the Hayabusa2 spacecraft. We analyzed 17 Ryugu samples measuring 1 to 8 millimeters. Carbon dioxide-bearing water inclusions are present within a pyrrhotite crystal, indicating that Ryugu's parent asteroid formed in the outer Solar System. The samples contain low abundances of materials that formed at high temperatures, such as chondrules and calcium- and aluminum-rich inclusions. The samples are rich in phyllosilicates and carbonates, which formed through aqueous alteration reactions at low temperature, high pH, and water/rock ratios of <1 (by mass). Less altered fragments contain olivine, pyroxene, amorphous silicates, calcite, and phosphide. Numerical simulations, based on the mineralogical and physical properties of the samples, indicate that Ryugu's parent body formed ~2 million years after the beginning of Solar System formation.
- Published
- 2023
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19. Chondrule-like objects and Ca-Al-rich inclusions in Ryugu may potentially be the oldest Solar System materials.
- Author
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Nakashima D, Nakamura T, Zhang M, Kita NT, Mikouchi T, Yoshida H, Enokido Y, Morita T, Kikuiri M, Amano K, Kagawa E, Yada T, Nishimura M, Nakato A, Miyazaki A, Yogata K, Abe M, Okada T, Usui T, Yoshikawa M, Saiki T, Tanaka S, Nakazawa S, Terui F, Yurimoto H, Noguchi T, Yabuta H, Naraoka H, Okazaki R, Sakamoto K, Watanabe SI, Tachibana S, and Tsuda Y
- Abstract
Chondrule-like objects and Ca-Al-rich inclusions (CAIs) are discovered in the retuned samples from asteroid Ryugu. Here we report results of oxygen isotope, mineralogical, and compositional analysis of the chondrule-like objects and CAIs. Three chondrule-like objects dominated by Mg-rich olivine are
16 O-rich and -poor with Δ17 O (=δ17 O - 0.52 × δ18 O) values of ~ -23‰ and ~ -3‰, resembling what has been proposed as early generations of chondrules. The16 O-rich objects are likely to be melted amoeboid olivine aggregates that escaped from incorporation into16 O-poor chondrule precursor dust. Two CAIs composed of refractory minerals are16 O-rich with Δ17 O of ~ -23‰ and possibly as old as the oldest CAIs. The discovered objects (<30 µm) are as small as those from comets, suggesting radial transport favoring smaller objects from the inner solar nebula to the formation location of the Ryugu original parent body, which is farther from the Sun and scarce in chondrules. The transported objects may have been mostly destroyed during aqueous alteration in the Ryugu parent body., (© 2023. The Author(s).)- Published
- 2023
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20. How to do it: endovascular stent and ligament resection during pancreaticoduodenectomy for coeliac axis stenosis in median arcuate ligament syndrome.
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Shintakuya R, Kohashi T, Nakashima A, Oishi K, Honmyo N, Hihara J, Kagawa E, and Mukaida H
- Subjects
- Constriction, Pathologic surgery, Humans, Ligaments surgery, Pancreaticoduodenectomy adverse effects, Stents, Median Arcuate Ligament Syndrome surgery
- Abstract
To decrease complications associated with the treatment of coeliac axis (CA) stenosis due to median arcuate ligament (MAL) syndrome in pancreaticoduodenectomy, we performed combined preoperative endovascular stenting and intraoperative MAL resection. This technique can secure the CA blood flow to the hepatic artery before surgery in one stage and prevent CA restenosis and stent dislocation because there is no extrinsic compression of the CA after MAL resection., (© 2021 Royal Australasian College of Surgeons.)
- Published
- 2021
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21. A mid-ventricular variant of Takotsubo syndrome: was it triggered by insular cortex damage?
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Osawa A, Nagai M, Dote K, Kato M, Oda N, Kunita E, Kagawa E, Yamane A, Kobatake H, Shiota H, Ishibashi N, Takahashi K, and Förster CY
- Subjects
- Aged, Cerebral Cortex diagnostic imaging, Female, Heart Ventricles, Humans, Brain Ischemia, Stroke, Takotsubo Cardiomyopathy diagnosis
- Abstract
Takotsubo syndrome (TTS) is a transient cardiomyopathy that is often associated with cerebrovascular diseases. Earlier studies have supported the concept that the cardiovascular system is regulated by a central autonomic network (CAN) consisting of the insular cortex (IC), anterior cingulate gyrus and amygdala. We report the case of a 79-year-old female diagnosed with a mid-ventricular variant of TTS concomitant with right IC ischaemic stroke. After 12 h of hospitalization, she experienced a sudden collapse. Rapid cardiopulmonary resuscitation resulted in a return of spontaneous circulation. Subsequent left ventriculography revealed akinesis in the mid-portion of the left ventricle with vigorous contraction of the basal and apex segment. Two weeks after admission, cardiac ultrasound showed improved left ventricular contraction. Right IC ischaemia in this patient might have been associated with a dysregulation of the CAN and subsequent increased sympathetic nervous system activity that triggered TTS., (© 2021 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology.)
- Published
- 2021
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22. Fibrous Connection Between Cervical Nerve and Zygapophysial Joint and Implication of the Cervical Spondylotic Radiculopathy: An Anatomic Cadaveric Study.
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Kagawa E, Nimura A, Nasu H, Kato R, and Akita K
- Subjects
- Humans, Radiculopathy pathology, Spondylosis pathology, Connective Tissue anatomy & histology, Spinal Nerves anatomy & histology, Zygapophyseal Joint anatomy & histology
- Abstract
Study Design: Observational, anatomical, cadaveric study., Objective: We anatomically investigated the fibrous connection between the cervical nerves and the zygapophysial joint capsules., Summary of Background Data: Cervical spondylotic radiculopathy is caused by the compression of the cervical nerves as the static factor and head and neck movements as the dynamic factor. To understand the dynamic pathology of cervical spondylotic radiculopathy, the anatomic relationship between the cervical nerves and the zygapophysial joints needs to be investigated in detail., Methods: In 11 cadavers, we dissected both sides from the C5 to C7. For macroscopic examination, we observed structures connecting the cervical nerves and the zygapophysial joints in 18 cervical nerves from three cadavers. In 14 sides of eight cadavers, we histologically analyzed the fibrous structures and their attachments., Results: Macroscopically, the fibrous band connected the cranial surface of the cervical nerve to the lateral and inferior aspects of the transverse process. In four of 18 nerves, the fibrous bands were divided into two fascicles by loose connective tissues. In addition, the fibrous bands extended along the dorsal aspect of the posterior tubercle of the transverse process and attached to the zygapophysial joint capsule. Histologically, densely stained fibrous tissues overlaid the zygapophysial joint capsule and extended to the recess between the posterior tubercle and inferior articular process on the cranial vertebral body., Conclusion: We macroscopically and histologically clarified the fibrous bands connecting the cervical nerve to the zygapophysial joint capsule. The fibrous bands may help clarify the pathology of cervical spondylotic radiculopathy associated with the zygapophysial joints as dynamic factors.Level of Evidence: N/A., (Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.)
- Published
- 2021
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23. Erdheim-Chester Disease With Left Atrial Pseudotumor Involvement.
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Kato M, Dote K, Oda N, Yamane A, Nagai M, Kagawa E, Kunita E, Fukushima N, and Ichinohe T
- Subjects
- Atrial Appendage, Biopsy, Heart Atria diagnostic imaging, Humans, Tomography, X-Ray Computed, Erdheim-Chester Disease diagnostic imaging
- Published
- 2021
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24. Early drop in systolic blood pressure, heart rate at admission, and their effects on worsening renal function in elderly patients with acute heart failure.
- Author
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Takeuchi M, Nagai M, Dote K, Kato M, Oda N, Kunita E, Kagawa E, Yamane A, Kobayashi Y, Shiota H, Osawa A, and Kobatake H
- Subjects
- Acute Disease, Aged, Aged, 80 and over, Disease Progression, Female, Heart Failure diagnosis, Humans, Kidney Diseases diagnosis, Male, Prospective Studies, Risk Assessment, Risk Factors, Time Factors, Blood Pressure, Heart Failure physiopathology, Heart Rate, Kidney physiopathology, Kidney Diseases physiopathology, Patient Admission
- Abstract
Background: Regardless of patients' baseline renal function, worsening renal function (WRF) during hospitalization is associated with poor outcomes. In individuals with acute heart failure (AHF), one predictor of WRF is an early drop in systolic blood pressure (SBP). Few studies have investigated WRF in elderly AHF patients or the influence of these patients' heart rate (HR) at admission on the relationship between an early SBP drop SBP and the AHF., Methods: We measured the SBP and HR of 245 elderly AHF inpatients (83 ± 6.0 years old, females 51%) at admission and another six times over the next 48 h. We defined 'WRF' as a serum creatinine increase ≥0.3 mg/dL by Day 5 post-admission. We calculated the 'early SBP drop' as the difference between the admission SBP value and the lowest value during the first 48 h of hospitalization., Results: There were significant differences between the 36 patients with WRF and the 209 patients without WRF: early SBP drop (51 vs. 33 mmHg, p < 0.01) and HR at admission (79 vs. 90 bpm, p < 0.05), respectively. In the multiple logistic regression analysis adjusted for the confounders, higher early SBP drop (p < 0.04) and lower HR at admission (p < 0.01) were significantly associated with WRF. No significant association was shown for the interaction term of early SBP drop × HR at admission with WRF., Conclusions: In these elderly AHF patients, exaggerated early SBP drop and lower HR at admission were significant independent predictors of WRF, and these factors were additively associated with WRF.
- Published
- 2020
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25. Happy heart syndrome: a case of Takotsubo syndrome with left internal carotid artery occlusion.
- Author
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Nagai M, Kobayashi Y, Kobatake H, Dote K, Kato M, Oda N, Kunita E, Kagawa E, Yamane A, Osawa A, Shiota H, Takeuchi M, and Förster CY
- Subjects
- Carotid Artery, Internal diagnostic imaging, Heart, Humans, Syndrome, Carotid Artery Diseases, Carotid Stenosis complications, Carotid Stenosis diagnostic imaging, Takotsubo Cardiomyopathy
- Published
- 2020
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26. Exaggerated coronary intimal thickening: an optical coherence tomography finding in myocardial bridge with concomitant spasm.
- Author
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Higashihara T, Nagai M, Dote K, Kato M, Oda N, Kunita E, Kagawa E, Yamane A, Kobayashi Y, Shiota H, and Takeuchi M
- Subjects
- Adult, Calcium Channel Blockers therapeutic use, Coronary Angiography, Coronary Vasospasm drug therapy, Coronary Vasospasm physiopathology, Coronary Vessels drug effects, Coronary Vessels physiopathology, Humans, Male, Myocardial Bridging drug therapy, Myocardial Bridging physiopathology, Predictive Value of Tests, Treatment Outcome, Vasodilator Agents therapeutic use, Coronary Vasospasm diagnostic imaging, Coronary Vessels diagnostic imaging, Myocardial Bridging diagnostic imaging, Neointima, Tomography, Optical Coherence, Vascular Remodeling drug effects, Vasoconstriction drug effects
- Published
- 2019
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27. Visit-to-visit Blood Pressure Variability and Arterial Stiffness: Which Came First: The Chicken or the Egg?
- Author
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Miyauchi S, Nagai M, Dote K, Kato M, Oda N, Kunita E, Kagawa E, Yamane A, Higashihara T, Takeuchi A, Tsuchiya A, and Takahari K
- Subjects
- Antihypertensive Agents pharmacology, Blood Pressure Determination, Calcium Channel Blockers pharmacology, Humans, Hypertension drug therapy, Blood Pressure, Vascular Stiffness
- Abstract
Earlier studies have shown that visit-to-visit blood pressure (BP) variability (VVV) served as a significant independent risk factor of stroke, specifically, in the high-risk elderly of cardiovascular disease (CVD). Although the mechanism is not clearly understood, arterial remodeling such as carotid artery, coronary artery and large aortic artery would be a strong moderator in the relationship between VVV and CVD incidence. Recent studies have provided evidence that VVV predicted the progression of arterial stiffness. While the class of antihypertensive agents is suggested to be an important determinant of VVV, long-acting calcium channel blockers use (CCBs) is associated with the reduction of VVV, and thus, is suggested to decrease the arterial stiffness. Specifically, the relationship between VVV and coronary arterial remodeling has never been reviewed until now. This article summarizes the recent literature on these topics. In the elderly hypertensives, strict BP control using CCBs could play a pivotal role in suppressing arterial stiffening via VVV reduction., (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)
- Published
- 2019
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28. A morphological comparison of the extraforaminal ligament between the cervical and thoracic regions.
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Nonthasaen P, Nasu H, Kagawa E, and Akita K
- Subjects
- Aged, Aged, 80 and over, Cadaver, Female, Humans, Japan, Male, Middle Aged, Cervical Vertebrae anatomy & histology, Ligaments, Articular anatomy & histology, Thoracic Vertebrae anatomy & histology
- Abstract
Purpose: The current study was conducted to clarify the morphology of the extraforaminal ligament (EFL) at the cervicothoracic junction and to compare the attachment of the EFL and the positional relation between the EFL and the spinal nerves, additionally to clarify the details within the connecting bundles at the cervicothoracic junction., Materials and Methods: The EFLs from the 4th cervical to the 4th thoracic vertebrae were dissected in 56 sides of 28 Japanese cadavers (11 males, 17 females). The range of age was 62.0-99.0 years. In addition, connecting bundles were analyzed by histological examination., Results: Ventral to the spinal nerve, the capsulotransverse ligament (CTL), transforaminal ligament (TFL) and the ligament between the 7th cervical vertebra and the 1st rib were attached to the transverse process and rib. The EFL ventral to the 1st thoracic nerve was not observed in all sides. Dorsal to the spinal nerve, the anterior part of the superior costotransverse ligament (ASCL) and the ligament homologous to the ASCL were attached to the transverse process and rib. The superior radiating ligament (SRL) and the ligament homologous to the SRL were identified. The connecting bundles identified between the 7th cervical and the 1st thoracic nerve were histologically confirmed to consist of nerves and vessels., Conclusions: The EFLs at the cervicothoracic junction were found to be homologous. The connecting bundles were observed between the 7th cervical and the 1st thoracic nerve. Interestingly, the 1st thoracic level alone might be a unique level at the cervicothoracic junction.
- Published
- 2018
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29. Predictors of favourable outcome after in-hospital cardiac arrest treated with extracorporeal cardiopulmonary resuscitation: A systematic review and meta-analysis.
- Author
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D'Arrigo S, Cacciola S, Dennis M, Jung C, Kagawa E, Antonelli M, and Sandroni C
- Subjects
- Adult, Age Factors, Biomarkers blood, Creatinine analysis, Female, Humans, Lactic Acid blood, Male, Observational Studies as Topic, Odds Ratio, Organ Dysfunction Scores, Retrospective Studies, Sex Factors, Treatment Outcome, Cardiopulmonary Resuscitation methods, Cardiopulmonary Resuscitation mortality, Extracorporeal Membrane Oxygenation mortality, Heart Arrest mortality, Heart Arrest therapy
- Abstract
Aims: To identify the predictors of survival to discharge in adults resuscitated with extracorporeal cardiopulmonary resuscitation (ECPR) following in-hospital cardiac arrest (IHCA)., Methods: MEDLINE and ISI Web of Science were searched for eligible studies. Pooled Odds Ratio (OR) and Pooled Mean Difference (PMD) for each predictor were calculated. The quality of evidence (QOE) was evaluated according to the GRADE guidelines., Results: Eleven studies were included totalling 856 patients. Of these, 324 (37.9%) survived to discharge. Good neurological outcome (Cerebral Performance Category 1 or 2) occurred in 222/263 (84.4%) survivors. Survival was associated with significantly higher odds of an initial shockable rhythm (OR 1.65; 95% confidence interval [95%CI] 1.05-2.61; p=0.03), shorter low-flow time (PMD -17.15 [-20.90, -13.40]min; p<0.00001), lower lactate levels both immediately before ECPR start (PMD -4.12 [-6.0,-2.24]mmol/L; p<0.0001) and on ICU admission (PMD -4.13 [-6.38, -1.88]mmol/L; p<0.0003), lower SOFA score (PMD -1.71 [-2.93, -0.50]; p=0.006) and lower creatinine levels within 24h after ICU admission (PMD -0.37 [-0.54, -0.19]mg/dl; p<0.00001). No significant association was found between survival and age, gender, or cardiac vs. non-cardiac aetiology. The overall QOE was low or very low., Conclusions: In adult IHCA treated with ECPR a shockable initial rhythm, a lower low-flow time, lower blood lactate levels before ECPR start or on ICU admission, and a lower SOFA score or creatinine levels in the first 24h after ICU admission were associated with a higher likelihood of survival. These factors could help identifying patients who are eligible for ECPR., (Copyright © 2017 Elsevier B.V. All rights reserved.)
- Published
- 2017
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30. Visit-to-Visit Blood Pressure Variability and Alzheimer's Disease: Links and Risks.
- Author
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Nagai M, Dote K, Kato M, Sasaki S, Oda N, Kagawa E, Nakano Y, Yamane A, Higashihara T, Miyauchi S, and Tsuchiya A
- Subjects
- Humans, Risk Factors, Vascular Stiffness physiology, Alzheimer Disease etiology, Blood Pressure physiology, Cognitive Dysfunction etiology, Hypertension complications
- Abstract
While hypertension has been shown to be a risk factor for vascular dementia, several studies have also demonstrated that hypertension also increases the risk of Alzheimer's disease (AD). Although the relationship between visit-to-visit blood pressure variability (VVV) and cognitive impairment, including AD, have been provided, the mechanisms remain poorly understood. This review paper focuses on the relationship of VVV with AD and summarizes the pathophysiology underlying that relationship, which appears to be mediated by arterial stiffness.
- Published
- 2017
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31. The Insular Cortex and Takotsubo Cardiomyopathy.
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Nagai M, Dote K, Kato M, Sasaki S, Oda N, Kagawa E, Nakano Y, Yamane A, Higashihara T, Miyauchi S, Tsuchiya A, Harada W, and Kario K
- Subjects
- Cerebral Cortex physiopathology, Humans, Takotsubo Cardiomyopathy physiopathology, Cerebral Cortex metabolism, Takotsubo Cardiomyopathy metabolism
- Abstract
Transient left ventricular dysfunction in patients under emotional stress, also known as Takotsubo cardiomyopathy, has been recognized as a distinct clinical entity. Recent studies have supported the concept notion that the cardiovascular system is regulated by cortical modulation. A network consisting of the insular cortex (Ic), anterior cingulate gyrus, and amygdala plays a crucial role in the regulation of the central autonomic nervous system in relation to emotional stress such as anxiety, fear and sadness. Because the Ic is located in the region of the middle cerebral arteries, its structure tends to be exposed to a higher risk of cerebrovascular disease. Ic damage has been associated with myocardial injury, increased brain natriuretic peptide, and the incidence of Takotsubo cardiomyopathy. Because Ic damage has been associated with increased sympathetic nervous system activity, Ic damage is suggested to have a pivotal role in the pathophysiology of Takotsubo cardiomyopathy. In this review, we focus on the role of the Ic as a mediator for the cardiovascular system in relation to emotional stress, and we summarizes the current knowledge on the relationships between the Ic and Takotsubo cardiomyopathy., (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.)
- Published
- 2017
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32. Intravascular ultrasound for morphological assessment of napkin-ring sign detected on multidetector computed tomography.
- Author
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Kato M, Dote K, Miura K, Yamaguchi Y, Miyauchi S, Higashihara T, Kubo Y, Yamane A, Nakano Y, Kagawa E, Nagai M, Oda N, and Sasaki S
- Subjects
- Aged, Aged, 80 and over, Coronary Vessels pathology, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Multivariate Analysis, Non-ST Elevated Myocardial Infarction pathology, Plaque, Atherosclerotic pathology, Coronary Angiography methods, Coronary Vessels diagnostic imaging, Multidetector Computed Tomography methods, Non-ST Elevated Myocardial Infarction diagnostic imaging, Plaque, Atherosclerotic diagnostic imaging, Ultrasonography, Interventional methods
- Abstract
Background: Although napkin-ring sign (NRS) plaques assessed by multidetector computed tomography (MDCT) is identified as a high-risk feature, the detailed morphological features are still unknown. The purpose of this study was to elucidate the morphological features of the MDCT-assessed NRS using intravascular ultrasound (IVUS)., Methods: We evaluated 204 plaques in 193 patients with non-ST-elevation acute coronary syndrome who were diagnosed using 128-slice MDCT and were assessed using IVUS prior to coronary intervention. Morphology was compared between plaques with and without MDCT-assessed NRS. Severe IVUS-assessed attenuation was defined as an attenuation angle >180°., Results: NRS was detected in 49 lesions. MDCT-assessed plaque attenuation was lower (p<0.0001), and cross-sectional plaque areas at lesion sites, remodeling index, and the prevalence of positive remodeling were greater, in lesions with NRS (p<0.005, p<0.0001, and p<0.0001, respectively). Furthermore, the IVUS-assessed remodeling index and prevalence of severe attenuation and speckled echo appearance were significantly greater in lesions with NRS (p<0.01, p<0.0001, and p<0.0001, respectively). Using multivariate analysis, IVUS-assessed speckled echo appearance was identified as an independent predictor of MDCT-assessed NRS (odds ratio, 3.59; 95% confidence interval, 1.49-8.66; p<0.005)., Conclusion: MDCT assessment of NRS may be associated with larger heterogeneous necrotic cores and greater positive remodeling., (Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.)
- Published
- 2016
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33. Visit-to-visit blood pressure variability and classes of antihypertensive agents; associations with artery remodeling and the risk of stroke.
- Author
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Nagai M, Dote K, Kato M, Sasaki S, Oda N, Kagawa E, Nakano Y, Yamane A, Kubo Y, Higashihara T, Miyauchi S, and Harada W
- Subjects
- Antihypertensive Agents administration & dosage, Antihypertensive Agents classification, Blood Pressure Determination, Calcium Channel Blockers administration & dosage, Calcium Channel Blockers classification, Calcium Channel Blockers therapeutic use, Carotid Arteries physiopathology, Humans, Hypertension complications, Hypertension epidemiology, Hypertension physiopathology, Risk, Stroke epidemiology, Stroke prevention & control, Antihypertensive Agents therapeutic use, Blood Pressure drug effects, Carotid Arteries drug effects, Hypertension drug therapy, Stroke etiology, Vascular Remodeling drug effects
- Abstract
Recent studies have shown that visit-to-visit blood pressure (BP) variability was emerging as an independent risk factor for stroke. Although the mechanism is not fully understood, artery remodeling would be closely associated with the relationship between visit-to-visit BP variability and stroke. In addition, the class of antihypertensive agents is suggested to be an important determinant of visit-to-visit BP variability. This review article summarizes the recent literature on these topics. In the elderly hypertensives, strict BP control using calcium channel blockade would play a crucial role to prevent stroke via reducing the visit-to-visit BP variability.
- Published
- 2016
- Full Text
- View/download PDF
34. Usefulness of brain natriuretic peptide for predicting left atrial appendage thrombus in patients with unanticoagulated nonvalvular persistent atrial fibrillation.
- Author
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Ochiumi Y, Kagawa E, Kato M, Sasaki S, Nakano Y, Itakura K, Takiguchi Y, Ikeda S, and Dote K
- Abstract
Background: The CHADS2 scoring system is simple and widely accepted for predicting thromboembolism in patients with nonvalvular atrial fibrillation (NVAF). Although congestive heart failure (CHF) is a component of the CHADS2 score, the definition of CHF remains unclear. We previously reported that the presence of CHF was a strong predictor of left atrial appendage (LAA) thrombus. Therefore, the present study aimed to elucidate the relationship between LAA thrombus and the brain natriuretic peptide (BNP) level in patients with unanticoagulated NVAF., Methods: The study included 524 consecutive patients with NVAF who had undergone transesophageal echocardiography to detect intracardiac thrombus before cardioversion between January 2006 and December 2008, at Hiroshima City Asa Hospital. The exclusion criteria were as follows: paroxysmal atrial fibrillation, unknown BNP levels, prothrombin time international normalized ratio ≥2.0, and hospitalization for systemic thromboembolism., Results: Receiver operating characteristic analysis yielded optimal plasma BNP cut-off levels of 157.1 pg/mL (area under the curve, 0.91; p<0.01) and 251.2 pg/mL (area under the curve, 0.70; p<0.01) for identifying CHF and detecting LAA thrombus, respectively. Multivariate analyses demonstrated that a BNP level >251.2 pg/mL was an independent predictor of LAA thrombus (odds ratio, 3.51; 95% confidence interval, 1.08-10.7; p=0.046)., Conclusions: In patients with unanticoagulated NVAF, a BNP level >251.2 pg/mL may be helpful for predicting the incidence of LAA thrombus and may be used as a surrogate marker of CHF. The BNP level is clinically useful for the risk stratification of systemic thromboembolism in patients with unanticoagulated NVAF.
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- 2015
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35. Do Lower Target Temperatures or Prolonged Cooling Provide Improved Outcomes for Comatose Survivors of Cardiac Arrest Treated With Hypothermia?
- Author
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Kagawa E, Dote K, Kato M, Sasaki S, Oda N, Nakano Y, Miura K, Inoue I, and Kihara Y
- Subjects
- Aged, Cardiopulmonary Resuscitation, Coma diagnosis, Coma mortality, Coma physiopathology, Extracorporeal Circulation, Female, Heart Arrest diagnosis, Heart Arrest mortality, Heart Arrest physiopathology, Humans, Hypothermia, Induced adverse effects, Hypothermia, Induced mortality, Japan, Male, Middle Aged, Registries, Retrospective Studies, Risk Assessment, Risk Factors, Time Factors, Treatment Outcome, Body Temperature Regulation, Coma therapy, Heart Arrest therapy, Hypothermia, Induced methods
- Abstract
Background: Optimal protocols for targeted temperature management are still unclear. This study investigated whether lower target temperatures and/or prolonged cooling could provide improved outcomes in comatose survivors of cardiac arrest., Methods and Results: This observational study was conducted using the prospectively collected targeted temperature management database in Hiroshima, Japan. Between September 2003 and September 2014, 237 patients treated with TTM after cardiac arrest were enrolled in this study. The target temperatures and durations were assigned by the treating physicians regardless of the patients' conditions. Favorable outcomes were defined as a cerebral performance category scale of 1 or 2 at the 90-day follow-up time point. The rate of favorable outcomes were similar between the patients whose protocols of target temperature were <34°C and ≥34°C (40% versus 35%, P=0.41), cooling durations were <28 and ≥28 hours (33% versus 44%, P=0.11), and rewarming durations were <28 and ≥28 hours (35% versus 41%, P=0.39). However, in patients treated with extracorporeal cardiopulmonary resuscitation, target temperatures <34°C were associated with more favorable outcomes (29% versus 8%, P=0.01). The cooling and rewarming durations >28 hours and target temperatures <34°C were associated with more frequent lethal arrhythmia, pneumonia, and/or bleedings., Conclusions: Prolonged durations of cooling and rewarming ≥28 hours may not improve outcomes and may increase complications. Further studies are necessary to assess the hypothesis that target temperatures <34°C provide improved outcomes in patients treated with extracorporeal cardiopulmonary resuscitation., (© 2015 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell.)
- Published
- 2015
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36. Association of nonculprit plaque characteristics with transient slow flow phenomenon during percutaneous coronary intervention.
- Author
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Miura K, Kato M, Dote K, Kagawa E, Nakano Y, Oda N, and Sasaki S
- Subjects
- Acute Coronary Syndrome diagnosis, Acute Coronary Syndrome mortality, Acute Coronary Syndrome physiopathology, Aged, Coronary Angiography methods, Female, Humans, Japan epidemiology, Male, Middle Aged, Multidetector Computed Tomography methods, Outcome Assessment, Health Care, Retrospective Studies, Risk Assessment, Risk Factors, Survival Analysis, Acute Coronary Syndrome surgery, Coronary Vessels pathology, Coronary Vessels physiopathology, Intraoperative Complications diagnosis, Intraoperative Complications physiopathology, No-Reflow Phenomenon diagnosis, No-Reflow Phenomenon etiology, No-Reflow Phenomenon physiopathology, Percutaneous Coronary Intervention adverse effects, Percutaneous Coronary Intervention methods, Plaque, Atherosclerotic diagnostic imaging, Plaque, Atherosclerotic physiopathology
- Abstract
Background: The slow flow (SF) phenomenon is more prevalent in patients with acute coronary syndrome (ACS), who frequently exhibit vulnerable plaques in remote coronary arteries. We aimed to clarify the impact of nonculprit plaque characteristics on the occurrence of SF using multidetector computed tomography (MDCT)., Methods: The study population comprised 180 consecutive patients with non-ST-segment elevation ACS (NSTE-ACS) who underwent MDCT before intervention. The characteristics of culprit and nonculprit lesions were compared between patients with and without SF., Results: SF was observed in 43 (23.8%) of the 180 patients. The prevalence of positive remodeling (PR), low-attenuation plaque (LAP), and napkin-ring sign (NRS) in culprit lesion was significantly higher in the SF group than in the non-SF group (86.1% vs. 39.4%; p<0.001, 81.4% vs. 18.3%; p<0.001, and 65.1% vs. 16.1%; p<0.001, respectively). The same result was observed for nonculprit lesions (58.1% vs. 14.6%; p<0.001, 45.2% vs. 6.6%; p<0.001, and 14.3% vs. 4.9%; p<0.04, respectively). Multivariate analysis revealed LAP [odds ratio (OR), 12.8; 95% confidence interval (CI), 3.7-54.7; p<0.001], and NRS (OR, 5.1; 95% CI, 1.3-25.3; p=0.03) in culprit lesions and PR (OR, 4.7; 95% CI, 1.1-22.2; p=0.04) in nonculprit lesions were independently associated with SF., Conclusions: The plaque characteristics of nonculprit lesions are associated with the occurrence of SF during percutaneous coronary intervention. Assessment of plaque characteristics of both culprit and nonculprit lesions using MDCT may be useful for the prediction of SF., (Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.)
- Published
- 2015
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37. A novel procedure for imaging acute coronary syndrome lesions using frequency-domain optical coherence tomography.
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Yamaguchi Y, Kagawa E, Kato M, Sasaki S, Nakano Y, Ochiumi Y, Takiguchi Y, Arakawa Y, Ishimaru A, Ueda A, and Dote K
- Subjects
- Acute Coronary Syndrome diagnosis, Aged, Aged, 80 and over, Coronary Angiography methods, Female, Humans, Male, Middle Aged, Acute Coronary Syndrome pathology, Coronary Vessels pathology, Tomography, Optical Coherence methods
- Published
- 2013
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38. Percutaneous coronary intervention for postcardiac arrest syndrome.
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Kagawa E, Dote K, and Kihara Y
- Subjects
- Combined Modality Therapy, Extracorporeal Membrane Oxygenation methods, Humans, Hypothermia, Induced methods, Out-of-Hospital Cardiac Arrest therapy, Treatment Outcome, Cardiopulmonary Resuscitation, Heart Arrest therapy, Percutaneous Coronary Intervention
- Abstract
Purpose of Review: Sudden cardiac arrest is a major cause of unexpected death, as well as a major clinical issue. Primary percutaneous coronary intervention (PCI) can drastically improve outcomes among patients with ST-elevation myocardial infarction without cardiac arrest. Recent studies reported that using emergency PCI to resuscitate patients has the potential to improve their outcomes. The purpose of this review is to elucidate the effects of PCI among resuscitated patients., Recent Findings: To the best of current understanding, no randomized clinical trial has assessed PCI for postcardiac arrest syndrome. Several observational studies suggested a positive effect of PCI for resuscitated out-of-hospital cardiac arrest (OHCA) patients, and a number of observational studies reported a limited beneficial effect. Several studies reported that a combination of therapeutic hypothermia and PCI may be feasible and effective. However, the presence of bias and unmeasured confounders in these studies may have affected the outcomes., Summary: PCI for postcardiac arrest syndrome may improve outcomes of OHCA patients; however, randomized trials of PCI for postcardiac arrest syndrome are necessary to confirm this issue. Alternative cardiopulmonary resuscitation using venoarterial extracorporeal membrane oxygenation and PCI may have the potential to improve the outcomes of refractory cardiac arrest patients.
- Published
- 2013
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39. Letter by Kagawa et al regarding article, "hypothermia in comatose survivors from out-of-hospital cardiac arrest: pilot trial comparing 2 levels of target temperature".
- Author
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Kagawa E, Dote K, and Kihara Y
- Subjects
- Female, Humans, Male, Body Temperature, Coma therapy, Heart Arrest therapy, Hypothermia, Induced methods, Out-of-Hospital Cardiac Arrest therapy
- Published
- 2013
- Full Text
- View/download PDF
40. Presentations of acute coronary syndrome related to coronary lesion morphologies as assessed by intravascular ultrasound and optical coherence tomography.
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Kato M, Dote K, Sasaki S, Kagawa E, Nakano Y, Watanabe Y, Higashi A, Itakura K, Ochiumi Y, and Takiguchi Y
- Subjects
- Aged, Diagnosis, Differential, Female, Humans, Male, Middle Aged, Radiography, Acute Coronary Syndrome diagnostic imaging, Coronary Artery Disease diagnostic imaging, Tomography, Optical Coherence methods, Ultrasonography, Interventional methods
- Abstract
Background: Pathologically, the lesions responsible for acute coronary syndrome (ACS) are ruptures of vulnerable plaques (and occasionally fibrous-cap erosions or calcified nodules) with a superimposed thrombosis. We aimed to clarify the clinical presentations related to the morphologies of coronary lesions of ACS using intravascular ultrasound (IVUS) and optical coherence tomography (OCT)., Methods and Results: Seventy-five culprit lesions of ACS patients were clearly assessed with IVUS and OCT. Patients were classified into two groups based on the presence or absence of a rupture of a culprit plaque as identified by OCT. Clinical characteristics and lesion morphologies were compared between the two groups. Waist circumference was significantly greater (p<0.02) and prevalence of the metabolic syndrome (MS) higher (p=0.0011) in the rupture group. The prevalence of prodromal angina was higher in patients without plaque ruptures (p<0.0001). Using multivariate analysis, the MS and prodromal angina were independent predictors of rupture of a culprit coronary plaque (odds ratio (OR): 27.30, p<0.003 and OR: 0.04, p=0.0004, respectively). Among the components of the MS, the prevalence of abdominal obesity was a significant independent predictor of rupture of a culprit plaque (OR: 4.24, p<0.02)., Conclusions: There are two presentations related to the coronary lesion morphologies of ACS: we should understand these aspects of ACS., (Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.)
- Published
- 2013
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41. Extracorporeal cardiopulmonary resuscitation for adult cardiac arrest patients.
- Author
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Kagawa E
- Abstract
Cardiac arrest is a major cause of unexpected death in developed countries, and patients with cardiac arrest generally have a poor prognosis. Despite the use of conventional cardiopulmonary resuscitation (CPR), few patients could achieve return of spontaneous circulation (ROSC). Even if ROSC was achieved, some patients showed re-arrest and many survivors were unable to fully resume their former lifestyles because of severe neurological deficits. Safar et al reported the effectiveness of emergency cardiopulmonary bypass in an animal model and discussed the possibility of employing cardiopulmonary bypass as a CPR method. Because of progress in medical engineering, the system of veno-arterial extracorporeal membrane oxygenation (ECMO) became small and portable, and it became easy to perform circulatory support in cardiac arrest or shock patients. Extracorporeal cardiopulmonary resuscitation (ECPR) has been reported to be superior to conventional CPR in in-hospital cardiac arrest patients. Veno- arterial ECMO is generally performed in emergency settings and it can be used to perform ECPR in patients with out-of-hospital cardiac arrest. Although there is no sufficient evidence to support the efficacy of ECPR in patients with out-of-hospital cardiac arrest, encouraging results have been obtained in small case series.
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- 2012
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42. Glucometabolic responses during Glucose Tolerance Test: a comparison between known diabetes and newly detected diabetes after acute myocardial infarction.
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Ishihara M, Inoue I, Kawagoe T, Shimatani Y, Kurisu S, Nakama Y, Kagawa E, Dai K, Ootani T, Ikenaga H, Morimoto Y, Ejiri K, and Oda N
- Subjects
- Aged, Body Mass Index, Female, Glycated Hemoglobin metabolism, Homeostasis physiology, Humans, Insulin blood, Insulin Resistance physiology, Male, Middle Aged, Predictive Value of Tests, Risk Factors, Blood Glucose metabolism, Diabetes Mellitus, Type 2 diagnosis, Diabetes Mellitus, Type 2 metabolism, Diabetes Mellitus, Type 2 mortality, Glucose Intolerance diagnosis, Glucose Intolerance metabolism, Glucose Intolerance mortality, Glucose Tolerance Test, Myocardial Infarction mortality
- Abstract
Background: Glucose Tolerance Test (GTT) newly detects diabetes (new diabetes) in a substantial number of patients without a history of diabetes (known diabetes) after acute myocardial infarction (AMI). Patients with new diabetes have poor outcomes, despite their lower HbA1c levels., Methods: This study consisted of 53 patients with new diabetes and 47 patients with known diabetes who underwent GTT 1 week after AMI. Sixty-eight patients with normal GTT and 78 patients with impaired glucose tolerance served as control. Plasma glucose and insulin were measured at fasting, 30 m, 60 m and 120 m after glucose load. Peak glucose-fasting glucose was used as a measure of glucose fluctuation. Homeostasis model assessment of insulin resistance and the Stumvoll's equations were used to assess insulin sensitivity and ß-cell function, respectively., Results: Fasting glucose (115 ± 20 mg/dl versus 129 ± 41 mg/dl, p=0.02) and hemoglobin A1C (5.7 ± 0.5% versus 6.7 ± 1.4%, p<0.001) in new diabetes were significantly lower than known diabetes. Insulin sensitivity was similarly impaired in both new diabetes and known diabetes (3.2 ± 2.2 versus 3.0 ± 1.9, p=0.58). Impairment of insulin secretion was less severe in new diabetes than in known diabetes. Peak glucose-fasting glucose was significantly greater in diabetic patients than inpatients with normal GTT (75 ± 30 mg/dl, p<0.001) and impaired glucose tolerance (95 ± 24 mg/dl, p<0.001), with no difference between new diabetes and known diabetes (156 ± 36 mg/dl versus 165 ± 57 mg/dl, p=0.36)., Conclusions: These findings suggested that insulin resistance and exaggerated glucose fluctuation could be attributable to poor outcomes after AMI in patients with new diabetes., (Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.)
- Published
- 2011
- Full Text
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43. Coexpression of aPKCλ/ι and IL-6 in prostate cancer tissue correlates with biochemical recurrence.
- Author
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Ishiguro H, Akimoto K, Nagashima Y, Kagawa E, Sasaki T, Sano JY, Takagawa R, Fujinami K, Sasaki K, Aoki I, Ohno S, Kubota Y, and Uemura H
- Subjects
- Adult, Aged, Humans, Immunohistochemistry, Male, Middle Aged, Prognosis, Proportional Hazards Models, Prostatic Neoplasms mortality, Prostatic Neoplasms pathology, Interleukin-6 analysis, Isoenzymes analysis, Neoplasm Recurrence, Local chemistry, Prostatic Neoplasms chemistry, Protein Kinase C analysis
- Abstract
Atypical protein kinase C λ/ι (aPKCλ/ι) and interleukin-6 (IL-6) have been implicated in prostate cancer progression, the mechanisms of which have been demonstrated both in vitro and in vivo. However, the clinical significance of the correlation between the expressions of these factors remains to be clarified. In the present study, we report a significant correlation between aPKCλ/ι and IL-6 proteins in prostate cancer tissue by immunohistochemical staining. We evaluated the association of both proteins by analyzing clinicopathological parameters using chi-square test, Kaplan-Meier with log-rank test, and a Cox proportional hazard regression model in univariate and multivariate analyses. The results again showed that the expression of aPKCλ/ι and IL-6 correlates in prostate cancer tissue (P < 0.001). Atypical protein kinase C λ/ι was also found to correlate with the Gleason score (P < 0.001) and with biochemical recurrence after prostatectomy (P = 0.02). Furthermore, aPKCλ/ι correlated with biochemical recurrence in a Kaplan-Meier and log-rank test (P = 0.01) and Cox analysis (P = 0.02 in the univariate analysis, P = 0.02 in the multivariate analysis). The coexpression of aPKCλ/ι and IL-6 also correlated with biochemical recurrence by Kaplan-Meier and log-rank test (P = 0.005) and Cox analysis (P = 0.01 in the univariate analysis, P = 0.03 in the multivariate analysis). These results indicate a strong correlation between aPKCλ/ι and IL-6 in prostate tumors, and that the aPKCλ/ι-IL-6 axis is a reliable prognostic factor for the biochemical recurrence of this cancer., (© 2011 Japanese Cancer Association.)
- Published
- 2011
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44. Incidence and treatment of left ventricular apical thrombosis in Tako-tsubo cardiomyopathy.
- Author
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Kurisu S, Inoue I, Kawagoe T, Ishihara M, Shimatani Y, Nakama Y, Maruhashi T, Kagawa E, and Dai K
- Subjects
- Aged, Aged, 80 and over, Female, Humans, Incidence, Anticoagulants therapeutic use, Heart Diseases drug therapy, Heart Diseases epidemiology, Heart Ventricles, Takotsubo Cardiomyopathy complications, Thrombosis drug therapy, Thrombosis epidemiology
- Abstract
Among 95 patients with Tako-tsubo cardiomyopathy, left ventricular (LV) apical thrombus was documented in 5 (5.3%) patients. The thrombus was mural in 2 (40%), and protruding in 3 (60%) patients. In 4 patients, LV apical thrombus disappeared after anticoagulant therapy. In one patient with protruding thrombus, brain infarction occurred. LV dysfunction was resolved during follow-up in all patients., (Copyright © 2008 Elsevier Ireland Ltd. All rights reserved.)
- Published
- 2011
- Full Text
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45. Chromophobe renal cell carcinoma with sarcomatoid transformation in a dog.
- Author
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Kobayashi N, Suzuki K, Murakami H, Kagawa E, Aoki I, and Nagashima Y
- Subjects
- Animals, Carcinoma, Renal Cell diagnosis, Carcinoma, Renal Cell pathology, Dog Diseases pathology, Dogs, Female, Carcinoma, Renal Cell veterinary, Dog Diseases diagnosis
- Abstract
A 12-year-old spayed female Siberian husky dog presented with hematuria and weight loss. An abdominal ultrasonographic examination revealed a left renal tumor measuring 8 cm in diameter, and a nephrectomy was performed. The resected kidney contained a cavitated tumor with a white solid region. Histologically, this tumor was composed of large polygonal cells with abundant and cloudy cytoplasm and focal sarcomatoid change. The neoplastic epithelial cells were reactive with colloidal iron staining; Dolichos biflorus agglutinin, peanut agglutinin, and Ulex europaeus agglutinin I lectins; and cluster of differentiation 10 and c-KIT antigens but not for periodic acid-Schiff or vimentin stain. Neoplastic sarcomatoid cells stained positive for vimentin. Because these histopathologic features are identical to those of human chromophobe renal cell carcinoma, the present case was diagnosed as canine chromophobe renal cell carcinoma.
- Published
- 2010
- Full Text
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46. Assessment of outcomes and differences between in- and out-of-hospital cardiac arrest patients treated with cardiopulmonary resuscitation using extracorporeal life support.
- Author
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Kagawa E, Inoue I, Kawagoe T, Ishihara M, Shimatani Y, Kurisu S, Nakama Y, Dai K, Takayuki O, Ikenaga H, Morimoto Y, Ejiri K, and Oda N
- Subjects
- Aged, Female, Heart Arrest mortality, Humans, Japan epidemiology, Male, Middle Aged, Retrospective Studies, Survival Rate trends, Treatment Outcome, Cardiopulmonary Resuscitation methods, Emergency Medical Services methods, Extracorporeal Circulation methods, Heart Arrest therapy, Inpatients, Intensive Care Units, Outpatients
- Abstract
Aim: Cardiopulmonary resuscitation (CPR) using extracorporeal life support (ECLS) for in-hospital cardiac arrest (IHCA) patients has been assigned a low-grade recommendation in current resuscitation guidelines. This study compared the outcomes of IHCA and out-of-hospital cardiac arrest (OHCA) patients treated with ECLS., Methods: A total of 77 patients were treated with ECLS. Baselines characteristics and outcomes were compared for 38 IHCA and 39 OCHA patients., Results: The time interval between collapse and starting ECLS was significantly shorter after IHCA than after OHCA (25 (21-43)min versus 59 (45-65)min, p<0.001). The weaning rate from ECLS (61% versus 36%, p=0.03) and 30-day survival (34% versus 13%, p=0.03) were higher for IHCA compared with OHCA patients. IHCA patients had a higher rate of favourable neurological outcome compared to OHCA patients, but the difference was not statistically significant (26% versus 10%, p=0.07). Kaplan-Meier analysis showed improved 30-day and 1-year survival for IHCA patients treated with ECLS compared to OHCA patients who had ECLS. However, multivariate stepwise Cox regression model analysis indicated no difference in 30-day (odds ratio 0.94 (95% confidence interval 0.68-1.27), p=0.67) and 1-year survival (0.99 (0.73-1.33), p=0.95)., Conclusion: CPR with ECLS led to more favourable patient outcomes after IHCA compared with OHCA in our patient group. The difference in outcomes for ECLS after IHCA and OHCA disappeared after adjusting for patient factors and the time delay in starting ECLS., (Copyright 2010 Elsevier Ireland Ltd. All rights reserved.)
- Published
- 2010
- Full Text
- View/download PDF
47. Effect of prodromal angina pectoris on the infarct progression in patients with first ST-elevation acute myocardial infarction.
- Author
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Maruhashi T, Ishihara M, Inoue I, Kawagoe T, Shimatani Y, Kurisu S, Nakama Y, Kagawa E, Dai K, Matsushita J, and Ikenaga H
- Subjects
- Aged, Coronary Angiography, Disease Progression, Electrocardiography, Female, Humans, Ischemic Preconditioning, Myocardial, Male, Middle Aged, Myocardial Infarction diagnosis, Time Factors, Angina Pectoris complications, Myocardial Infarction pathology
- Abstract
Background: Prodromal angina pectoris (AP) has a cardioprotective effect by the mechanism of ischemic preconditioning, and the QRS score on the admission electrocardiogram (ECG) reflects myocardial damage at presentation. This study was undertaken to investigate the effect of prodromal AP on infarct progression after the onset of acute myocardial infarction (AMI)., Methods and Results: The study group comprised 291 patients with a first ST-elevation AMI who underwent coronary angiography within 24 h of symptom onset. QRS score was calculated from the admission ECG. Patients were divided into 3 groups according to elapsed time from onset of AMI to angiography: early group (<2 h), intermediate group (2-6 h) and late group (6-24 h). Prodromal AP was defined as angina occurring 24 h before the onset of AMI. Patients with prodromal AP (n=101; 35%) had a significantly lower QRS score than those without (2.4+/-2.4 vs 3.2+/-3.0, P=0.02). In patients without prodromal AP, the QRS score linearly increased as elapsed time increased: 2.6+/-2.8, 3.0+/-3.0 and 5.5+/-2.9 in the early, intermediate and late groups, respectively. In patients with prodromal AP, the QRS score remained low until 6 h after onset and then increased: 2.0+/-1.8, 2.0+/-2.1, and 4.1+/-3.3, respectively., Conclusions: The findings suggested that prodromal AP might delay infarct progression during the early hours after the onset of AMI and extend the window of time for reperfusion therapy.
- Published
- 2010
- Full Text
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48. Tako-tsubo cardiomyopathy after successful resuscitation of out-of-hospital cardiac arrest.
- Author
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Kurisu S, Inoue I, Kawagoe T, Ishihara M, Shimatani Y, Nakama Y, Kagawa E, Dai K, and Ikenaga H
- Subjects
- Adult, Aged, Fatal Outcome, Female, Heart Arrest therapy, Humans, Male, Heart Arrest etiology, Resuscitation, Takotsubo Cardiomyopathy complications
- Abstract
A 69-year-old woman and a 29-year-old man were admitted to our hospital after successful resuscitation of out-of hospital cardiac arrest. In the first case, electrocardiogram showed mild ST-segment elevation in leads V3-V5. Coronary angiography did not show any obstructive coronary artery disease, and left ventriculography showed apical ballooning of the left ventricular chamber. She was diagnosed as having the classic form of tako-tsubo cardiomyopathy. In the second case, electrocardiogram did not show ST-segment elevation in any lead. Coronary angiography showed no coronary artery disease and left ventriculography showed basal ballooning of the left ventricular chamber. He was diagnosed as having the variant form of tako-tsubo cardiomyopathy. In both cases, left ventricular function returned to normal, but they died of multiple organ failure. In conclusion, cardiologists should recognize that takotsubo cardiomyopathy can occur even after successful resuscitation of cardiac arrest. Early diagnosis and appropriate intensive care are essential in these critically ill patients.
- Published
- 2010
- Full Text
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49. Coronary angioscopic findings eight months after sirolimus-eluting stent implantation: a comparison between ST-elevation myocardial infarction and stable angina pectoris.
- Author
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Dai K, Ishihara M, Inoue I, Kawagoe T, Shimatani Y, Kurisu S, Nakama Y, Maruhashi T, Kagawa E, Aokage T, Matsushita J, and Ikenaga H
- Subjects
- Aged, Female, Humans, Male, Prosthesis Implantation, Thrombosis diagnosis, Time Factors, Angina Pectoris diagnosis, Angina Pectoris therapy, Angioscopy, Coronary Vessels, Drug-Eluting Stents, Myocardial Infarction diagnosis, Myocardial Infarction therapy, Sirolimus administration & dosage
- Abstract
Aims: Conflicting data exist about the safety of the sirolimus-eluting stent (SES) for patients with ST-elevation myocardial infarction (STEMI). Previous studies have reported delayed neointimal proliferation over SES with high incidence of adhering thrombus. This study was undertaken to assess the neointimal coverage and thrombus formation after SES implantation between patients with STEMI and those with stable angina pectoris (SAP)., Methods and Results: We studied 23 patients with STEMI who underwent primary percutaneous coronary intervention (PCI) with SES and 18 patients with SAP who were treated with SES. Coronary angioscopic examination was performed 8.1+/-2.4 months after PCI. Neointimal coverage of the stent was classified into four grades (grade 0 to 3). Uncovered stent strut was defined as grade 0 or 1. All the patients with STEMI and 94% of patients with SAP had uncovered stent struts. There was no significant difference in minimum, maximum, and dominant neointimal coverage grade between STEMI and SAP. 96% of patients with STEMI and all the patients with SAP showed heterogeneous neointimal coverage. Thrombus adhering to uncovered stent struts was observed in eight patients after STEMI and in four patients after SAP (35% vs. 22%, p=0.38). There was no significant difference in the maximum colour grade of the plaques between STEMI and SAP (2.1+/-0.8 vs. 1.8+/-0.9, p=0.33). Most thrombus was observed at the site of yellow plaques (83%)., Conclusions: There was no significant difference in the neointimal coverage and thrombus formation between STEMI and SAP.
- Published
- 2010
- Full Text
- View/download PDF
50. Accidental connection between the atrial and ventricular stylets during a stimulation threshold test for pacemaker implantation.
- Author
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Kurisu S, Inoue I, Kawagoe T, Ishihara M, Shimatani Y, Nakama Y, Maruhashi T, Kagawa E, Dai K, Matsushita J, and Ikenaga H
- Subjects
- Aged, Electrocardiography, Electrophysiologic Techniques, Cardiac, Equipment Design, Heart Atria physiopathology, Heart Ventricles physiopathology, Humans, Male, Sensory Thresholds, Sick Sinus Syndrome physiopathology, Accidents, Cardiac Pacing, Artificial adverse effects, Medical Errors, Pacemaker, Artificial, Sick Sinus Syndrome therapy
- Abstract
This report describes a case of atrioventricular crosstalk during a stimulation threshold test. This phenomenon was likely due to the accidental connection between the atrial and ventricular stylets. Electrocardiologists should recognize atrioventricular crosstalk during a stimulation threshold test to avoid repositioning the atrial lead unnecessarily or inducing ventricular arrhythmia.
- Published
- 2010
- Full Text
- View/download PDF
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