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323 results on '"Kühn, Jens-Peter"'

12. Lower muscular strength is associated with greater liver fat content and higher serum liver enzymes—"The Sedentary's Liver" The Study of Health in Pomerania.

Author

Mayer, Claudius, Ittermann, Till, Schipf, Sabine, Gross, Stefan, Kim, Simon, Schielke, Jan, Bülow, Robin, Kühn, Jens‐Peter, Lerch, Markus M., Völzke, Henry, Felix, Stephan Burkhard, Bahls, Martin, Targher, Giovanni, Dörr, Marcus, and Markus, Marcello Ricardo Paulista

Subjects
CROSS-sectional method, FATTY liver, RESEARCH funding, MULTIPLE regression analysis, SEDENTARY lifestyles, MAGNETIC resonance imaging, MUSCLE strength, GAMMA-glutamyltransferase, ODDS ratio, PHYSICAL fitness, CONFIDENCE intervals, GRIP strength, AMINOTRANSFERASES
Abstract

We investigated the associations of low handgrip strength (HGS, i.e., a marker of muscular fitness) with liver fat content (LFC) and serum liver enzymes in a population‐based setting. We used data from 2700 participants (51.7% women), aged 21–90 years, from two independent cohorts of the population‐based Study of Health in Pomerania (SHIP‐START‐2 and SHIP‐TREND‐0). Cross‐sectional, multivariable adjusted regression models were performed to examine the associations of HGS with LFC, measured by magnetic resonance imaging and serum liver enzymes. We found significant inverse associations of HGS with both LFC and serum liver enzymes. Specifically, a 10‐kg lower HGS was associated with a 0.59% (95% confidence interval [CI]: 0.24–0.94; p = 0.001) higher LFC, a 0.051 µkatal/L (95% CI: 0.005–0.097; p = 0.031) higher gamma‐glutamyltransferase (GGT) concentration and a 0.010 µkatal/L (95% CI: 0.001–0.020; p = 0.023) higher aspartate aminotransferase (AST) concentration. The adjusted odds‐ratio for prevalent hepatic steatosis (defined by a MRI‐PDFF ≥5.1%) per 10‐kg lower HGS was 1.21 (95% CI: 1.04–1.40; p = 0.014). When considering only obese individuals, those with low HGS had a 1.58% (95% CI: 0.18–2.98; p = 0.027) higher mean LFC and higher chance of prevalent hepatic steatosis (adjusted OR 1.74, 95% CI: 1.15–2.62; p = 0.009) compared to individuals with high HGS. We found similar associations in individuals with overweight, but not in those with normal weight. Lower HGS was strongly associated with both higher LFC and higher serum GGT and AST concentrations. Future studies might clarify whether these findings reflect adverse effects of a sedentary lifestyle or aging on the liver. Highlights: We used magnetic resonance imaging, the most accurate and sensitive noninvasive diagnostic tool for determination of hepatic steatosisLower handgrip strength was strongly associated with both higher liver fat content and higher serum GGT and AST concentrationsEspecially overweight and obese individuals with low handgrip strength had a significant higher risk of prevalent hepatic steatosis [ABSTRACT FROM AUTHOR]

Published
2024
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13. Cardiac remodelling in non‐alcoholic fatty liver disease in the general population.

Author

Kostka, Frederik, Ittermann, Till, Groß, Stefan, Laqua, Fabian Christopher, Bülow, Robin, Völzke, Henry, Dörr, Marcus, Kühn, Jens Peter, Markus, Marcello Ricardo Paulista, and Kromrey, Marie‐Luise

Subjects
NON-alcoholic fatty liver disease, GLOBAL longitudinal strain, CARDIAC magnetic resonance imaging
Abstract

Background and Aims: Non‐alcoholic fatty liver disease (NAFLD) is associated with increased risk for cardiovascular disease. Our study investigates the contribution of NAFLD to changes in cardiac structure and function in a general population. Methods: One thousand ninety‐six adults (49.3% female) from the Study of Health in Pomerania underwent magnetic resonance imaging including cardiac and liver imaging. The presence of NAFLD by proton density fat fraction was related to left cardiac structure and function. Results were adjusted for clinical confounders using multivariable linear regression model. Results: The prevalence for NAFLD was 35.9%. In adjusted multivariable linear regression models, NAFLD was positively associated with higher left ventricular mass index (β = 0.95; 95% confidence interval (CI): 0.45; 1.45), left ventricular concentricity (β = 0.043; 95% CI: 0.031; 0.056), left ventricular end‐diastolic wall thickness (β = 0.29; 95% CI: 0.20; 0.38), left atrial end‐diastolic volume index (β = 0.67; 95% CI: 0.01; 1.32) and inversely associated with left ventricular end‐diastolic volume index (β = −0.78; 95% CI: −1.51; −0.05). When stratified by sex, we only found significant positive associations of NAFLD with left ventricular mass index, left atrial end‐diastolic volume index, left ventricular cardiac output and an inverse association with global longitudinal strain in women. In contrast, men had an inverse association with left ventricular end‐diastolic volume index and left ventricular stroke volume. Higher liver fat content was stronger associated with higher left ventricular mass index, left ventricular concentricity and left ventricular end‐diastolic wall thickness. Conclusion: NAFLD is associated with cardiac remodelling in the general population showing sex specific patterns in cardiac structure and function. [ABSTRACT FROM AUTHOR]

Published
2024
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27. Definition of age-dependent reference values for the diameter of the common bile duct and pancreatic duct on MRCP: a population-based, cross-sectional cohort study.

Author

Beyer, Georg, Kasprowicz, Florian, Hannemann, Anke, Aghdassi, Ali, Thamm, Patrick, Volzke, Henry, Lerch, Markus M., Kühn, Jens-Peter, and Mayerle, Julia

Subjects
PANCREATIC duct, BILE ducts, WHOLE body imaging, CHOLECYSTITIS, REFERENCE values, PANCREATIC intraepithelial neoplasia, COHORT analysis, DIAMETER
Published
2023
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31. Subpopulation Discovery in Epidemiological Data with Subspace Clustering

Author

Niemann Uli, Spiliopoulou Myra, Völzke Henry, and Kühn Jens-Peter

Subjects
Electronic computers. Computer science, QA75.5-76.95
Abstract

A prerequisite of personalized medicine is the identification of groups of people who share specific risk factors towards an outcome. We investigate the potential of subspace clustering for finding such groups in epidemiological data. We propose a workflow that encompasses clusterability assessment before cluster discovery and quality assessment after learning the clusters. Epidemiological usually do not have a ground truth for the verification of clusters found in subspaces. Hence, we introduce quality assessment through juxtaposition of the learned models to “models-of-randomness”, i.e. models that do not reflect a true cluster structure. On the basis of this workflow, we select subspace clustering methods, compare and discuss their performance. We use a dataset with hepatic steatosis as outcome, but our findings apply on arbitrary epidemiological cohort data that have tenths of variables and exhibit class skew.

Published
2014
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43. Value of Clinical Information on Radiology Reports in Oncological Imaging.

Author

Schön, Felix, Sinzig, Rebecca, Walther, Felix, Radosa, Christoph Georg, Nebelung, Heiner, Eberlein-Gonska, Maria, Hoffmann, Ralf-Thorsten, Kühn, Jens-Peter, and Blum, Sophia Freya Ulrike

Subjects
RADIOLOGY, COMPUTED tomography, RADIOLOGISTS
Abstract

Radiological reporting errors have a direct negative impact on patient treatment. The purpose of this study was to investigate the contribution of clinical information (CI) in radiological reporting of oncological imaging and the dependence on the radiologists' experience level (EL). Sixty-four patients with several types of carcinomas and twenty patients without tumors were enrolled. Computed tomography datasets acquired in primary or follow-up staging were independently analyzed by three radiologists (R) with different EL (R1: 15 years; R2: 10 years, R3: 1 year). Reading was initially performed without and 3 months later with CI. Overall, diagnostic accuracy and sensitivity for primary tumor detection increased significantly when receiving CI from 77% to 87%; p = 0.01 and 73% to 83%; p = 0.01, respectively. All radiologists benefitted from CI; R1: 85% vs. 92%, p = 0.15; R2: 77% vs. 83%, p = 0.33; R3: 70% vs. 86%, p = 0.02. Overall, diagnostic accuracy and sensitivity for detecting lymphogenous metastases increased from 80% to 85% (p = 0.13) and 42% to 56% (p = 0.13), for detection of hematogenous metastases from 85% to 86% (p = 0.61) and 46% to 60% (p = 0.15). Specificity remained stable (>90%). Thus, CI in oncological imaging seems to be essential for correct radiological reporting, especially for residents, and should be available for the radiologist whenever possible. [ABSTRACT FROM AUTHOR]

Published
2022
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