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1. Author Correction: Titers of antibodies against ancestral SARS-CoV-2 correlate with levels of neutralizing antibodies to multiple variants

Author

Tran, Trung The, Vaage, Eline Benno, Mehta, Adi, Chopra, Adity, Tietze, Lisa, Kolderup, Anette, Anthi, Aina, König, Marton, Nygaard, Gro, Lind, Andreas, Müller, Fredrik, Nissen-Meyer, Lise Sofie, Magnus, Per, Trogstad, Lill, Mjaaland, Siri, Søraas, Arne, Midtvedt, Karsten, Åsberg, Anders, Barratt-Due, Andreas, Medhus, Asle W., Høivik, Marte Lie, Lundin, Knut, Karlsen, Randi Fuglaas, Dahle, Reidun, Danielsson, Karin, Thomassen, Kristine Stien, Kro, Grete Birkeland, Cox, Rebecca J., Zhou, Fan, Langeland, Nina, Aukrust, Pål, Melum, Espen, Åvitsland, Tone Lise, Wiencke, Kristine, Holter, Jan Cato, Munthe, Ludvig A., Grødeland, Gunnveig, Andersen, Jan-Terje, Vaage, John Torgils, and Lund-Johansen, Fridtjof

Published
2023
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2. Casemix, management, and mortality of patients receiving emergency neurosurgery for traumatic brain injury in the Global Neurotrauma Outcomes Study: a prospective observational cohort study

Author

Abbas, Ghayur, Abdallah, Omar Ibrahim, Abdel-Lateef, Ahmed, Abdifatah, Khalif, Abdullateef, Awfa, Abeygunaratne, Ruvini, Aboellil, Mostafa, Adam, Abass, Adams, Robert, Adeleye, Amos, Adeolu, Augustine, Adji, Novan Krisno, Afianti, Nur, Agarwal, Sudarsan, Aghadi, Ifeanyi Kene, Aguilar, Paúl Martín Méndez, Ahmad, Syeda Rida, Ahmed, Daniyal, Ahmed, Nafees, Aizaz, Haider, Aji, Yunus Kuntawi, Alamri, Alex, Alberto, Augusto Jacinto Mussindo, Alcocer, Luis Alcocer, Alfaro, Lesly Gonzales, Al-Habib, Amro, Alhourani, Ahmad, Ali, Syed Muhammad Rafay, Alkherayf, Fahad, AlMenabbawy, Ahmed, Alshareef, Aliyah, Aminullah, Muhammad Adil s/o, Amjad, Madeha, Amorim, Robson Luis Oliveira de, Anbazhagan, Sathiaprabhu, Andrade, Almir, Antar, Waleed, Anyomih, Theophilus T.K., Aoun, Salah, Apriawan, Tedy, Armocida, Daniele, Arnold, Paul, Arraez, Miguel, Assefa, Temesgen, Asser, Andres, Athiththan, S.P., Attanayake, Deepal, Aung, Maung Maung, Avi, Allan, Ayala, Victor Enrique Antolinez, Azab, Mohammed, Azam, Gaousul, Azharuddin, Mohd, Badejo, Olukemi, Badran, Mohamed, Baig, Azam Ali, Baig, Rehman Ali, Bajaj, Ankur, Baker, Paul, Bala, Renu, Balasa, Artur, Balchin, Ross, Balogun, James, Ban, Vin Shen, Bandi, Bharath Kumar Reddy, Bandyopadhyay, Soham, Bank, Matthew, Barthelemy, Ernest, Bashir, Mohammed Talha, Basso, Luciano Silveira, Basu, Surajit, Batista, Auricelio, Bauer, Marlies, Bavishi, Devi, Beane, Abi, Bejell, Shmuel, Belachew, Anteneh, Belli, Antonio, Belouaer, Amani, Bendahane, Najia El Abbadi, Benjamin, Okanga, Benslimane, Youssef, Benyaiche, Chaymae, Bernucci, Claudio, Berra, Luigi Valentino, Bhebe, Arnold, Bimpis, Alexios, Blanaru, Diana, Bonfim, Jean Claude, Borba, Luis A B, Borcek, Alp Ozgun, Borotto, Erika, Bouhuwaish, Ahmad Elmabri Mohammad, Bourilhon, Facundo, Brachini, Gioia, Breedon, Joshua, Broger, Maximilian, Brunetto, Giacoma Maria Floriana, Bruzzaniti, Placido, Budohoska, Natalia, Burhan, Hira, Calatroni, Maximiliano Luis, Camargo, Catherine, Cappai, Pier Francesco, Cardali, Salvatore Massimiliano, Castaño-Leon, Ana M, Cederberg, David, Celaya, Mikel, Cenzato, Marco, Challa, Lakshmi Madhavi, Charest, Dhanny, Chaurasia, Bipin, Chenna, Rabah, Cherian, Iype, Ching'o, Juliana Henry, Chotai, Tejas, Choudhary, Ajay, Choudhary, Nabeel, Choumin, Florence, Cigic, Tomislav, Ciro, Juan, Conti, Carlo, Corrêa, Antônio Carlos de Souza, Cossu, Giulia, Couto, Maíra Piani, Cruz, Aurora, D'Silva, Divya, D'Aliberti, Giuseppe Antonio, Dampha, Lamin, Daniel, Roy Thomas, Dapaah, Andrew, Darbar, Aneela, Dascalu, Gabriel, Dauda, Happy Amos, Davies, Owain, Delgado-Babiano, Andrea, Dengl, Markus, Despotovic, Marko, Devi, Indira, Dias, Celeste, Dirar, Mohamed, Dissanayake, Melina, Djimbaye, Hananiah, Dockrell, Simon, Dolachee, Ali, Dolgopolova, Julija, Dolgun, Muge, Dow, Abdalrouf, Drusiani, Davide, Dugan, Artjom, Duong, Dinh Tuan, Duong, Trung Kien, Dziedzic, Tomasz, Ebrahim, Ali, El Fatemi, Nizar, El Helou, Antonios El, El Maaqili, Rachid El, El Mostarchid, Brahim El, El Ouahabi, Abdessamad El, Elbaroody, Mohammad, El-Fiki, Ahmed, El-Garci, Ahmed, El-Ghandour, Nasser M.F., Elhadi, Muhammed, Elleder, Vanessa, Elrais, Safa, El-shazly, Mohamed, Elshenawy, Mohamed, Elshitany, Hesham, El-Sobky, Omar, Emhamed, Marwa, Enicker, Basil, Erdogan, Onur, Ertl, Sebastian, Esene, Ignatius, Espinosa, Omar Ocampo, Fadalla, Tarig, Fadelalla, Mohammed, Faleiro, Rodrigo Moreira, Fatima, Nida, Fawaz, Charbel, Fentaw, Assefa, Fernandez, Carla Eiriz, Ferreira, Ana, Ferri, Francesco, Figaji, Tony, Filho, Emerson L B, Fin, Loic, Fisher, Benjamin, Fitra, Fitra, Flores, Alexis Palpan, Florian, Ioan Stefan, Fontana, Vincenzo, Ford, Lauren, Fountain, Daniel, Frade, Jose Maria Roda, Fratto, Antonio, Freyschlag, Christian, Gabin, Aranzazu Sánchez, Gallagher, Clare, Ganau, Mario, Gandia-Gonzalez, Maria Luisa, Garcia, Andoni, Garcia, Borja Hernandez, Garusinghe, Sanjeewa, Gebreegziabher, Biniam, Gelb, Adrian, George, Jerome St, Germanò, Antonino Francesco, Ghetti, Ilaria, Ghimire, Prajwal, Giammarusti, Alessandro, Gil, Jose Luis, Gkolia, Panagiota, Godebo, Yoseph, Gollapudi, Prakash Rao, Golubovic, Jagos, Gomes, Jeremias Fernando, Gonzales, Javier, Gormley, William, Gots, Alexander, Gribaudi, Giulia Letizia, Griswold, Dylan, Gritti, Paolo, Grobler, Ruan, Gunawan, Rudy, Hailemichael, Birhanu, Hakkou, Elmehdi, Haley, Mark, Hamdan, Alhafidz, Hammed, Ali, Hamouda, Waeel, Hamzah, Nurul Ashikin, Han, Nyein Latt, Hanalioglu, Sahin, Haniffa, Rashan, Hanko, Martin, Hanrahan, John, Hardcastle, Timothy, Hassani, Fahd Derkaoui, Heidecke, Volkmar, Helseth, Eirik, Hernández-Hernández, Miguel Ángel, Hickman, Zachary, Hoang, Le Minh Chau, Hollinger, Alexa, Horakova, Lenka, Hossain-Ibrahim, Kismet, Hou, Boru, Hoz, Samer, Hsu, Janine, Hunn, Martin, Hussain, Madiha, Iacopino, Giorgia, Ideta, Mylena Miki Lopes, Iglesias, Irene, Ilunga, Ali, Imtiaz, Nafiz, Islam, Rafiza, Ivashchenko, Serge, Izirouel, Karim, Jabal, Mohamed Sobhi, Jabal, Soubhi, Jabang, John Nute, Jamjoom, Aimun, Jan, Irfan, Jarju, Landing BM, Javed, Saad, Jelaca, Bojan, Jhawar, Sukhdeep Singh, Jiang, Ting Ting, Jimenez, Fernando, Jiris, Jorge, Jithoo, Ron, Johnson, Walt, Joseph, Mathew, Joshi, Rameshman, Junttila, Eija, Jusabani, Mubashir, Kache, Stephen Akau, Kadali, Satyavara Prasad, Kalkmann, Gabriela F, Kamboh, Usman, Kandel, Hitham, Karakus, Ahmet Kamil, Kassa, Mengistu, Katila, Ari, Kato, Yoko, Keba, Martin, Kehoe, Kristy, Kertmen, Huseyin Hayri, Khafaji, Soha, Khajanchi, Monty, Khan, Mohammed, Khan, Muhammad Mukhtar, Khan, Sohail Daud, Khizar, Ahtesham, Khriesh, Amir, Kierońska, Sara, Kisanga, Paul, Kivevele, Boniface, Koczyk, Kacper, Koerling, Anna-Lucia, Koffenberger, Danielle, Kõiv, Kennet, Kõiv, Leho, Kolarovszki, Branislav, König, Marton, Könü-Leblebicioglu, Dilek, Koppala, Santhoshi Devi, Korhonen, Tommi, Kostkiewicz, Boguslaw, Kostyra, Kacper, Kotakadira, Srinivas, Kotha, Arjun Reddy, Kottakki, Madhu Narayana Rao, Krajcinovic, Nenad, Krakowiak, Michal, Kramer, Andreas, Krishnamoorthy, Selvamuthukumaran, Kumar, Ashok, Kumar, Pankaj, Kumar, Pradhumna, Kumarasinghe, Nilaksha, Kuncha, Gowtham, Kutty, Raja K., Laeke, Tsegazeab, Lafta, Ghazwan, Lammy, Simon, Lapolla, Pierfrancesco, Lardani, Jacopo, Lasica, Nebojsa, Lastrucci, Giancarlo, Launey, Yoann, Lavalle, Laura, Lawrence, Tim, Lazaro, Albert, Lebed, Vitalii, Leinonen, Ville, Lemeri, Lawrence, Levi, Leon, Lim, Jia Yi, Lim, Xiao Yi, Linares-Torres, Jorge, Lippa, Laura, Lisboa, Lurdes, Liu, Jinfang, Liu, Ziyuan, Lo, William B, Lodin, Jan, Loi, Federico, Londono, Daniella, Lopez, Pedro Antonio Gomez, López, Cristina Barceló, Lotbiniere-Bassett, Madeleine De, Lulens, Rihards, Luna, Facundo Hector, Luoto, Teemu, M.V., Vijaya Sekhar, Mabovula, Ndyebo, MacAllister, Matthew, Macie, Alcina Americo, Maduri, Rodolfo, Mahfoud, Moufid, Mahmood, Ashraf, Mahmoud, Fathia, Mahoney, Dominic, Makhlouf, Wissam, Malcolm, George, Malomo, Adefolarin, Malomo, Toluyemi, Mani, Manoranjitha Kumari, Marçal, Tomás Gazzinelli, Marchello, Jacopo, Marchesini, Nicolò, Marhold, Franz, Marklund, Niklas, Martín-Láez, Rubén, Mathaneswaran, Vickneswaran, Mato-Mañas, David José, Maye, Helen, McLean, Aaron Lawson, McMahon, Catherine, Mediratta, Saniya, Mehboob, Mehreen, Meneses, Alisson, Mentri, Nesrine, Mersha, Hagos, Mesa, Ana Milena, Meyer, Cristy, Millward, Christopher, Mimbir, Salomao Amone, Mingoli, Andrea, Mishra, Parashruram, Mishra, Tejesh, Misra, Basant, Mittal, Siddharth, Mohammed, Imran, Moldovan, Ioana, Molefe, Masechaba, Moles, Alexis, Moodley, Preston, Morales, Mario Augusto Narváez, Morgan, Lucy, Morillo, German Del Castillo, Moustafa, Wahab, Moustakis, Nikolaos, Mrichi, Salma, Munjal, Satya Shiva, Muntaka, Abdul-Jalilu Mohammed, Naicker, Denver, Nakashima, Paulo E H, Nandigama, Pratap Kumar, Nash, Samantha, Negoi, Ionut, Negoita, Valetina, Neupane, Samundra, Nguyen, Manh Hung, Niantiarno, Fajar Herbowo, Noble, Abbi, Nor, Mohd Arman Muhamad, Nowak, Blazej, Oancea, Andrei, O'Brien, Frazer, Okere, Oghenekevwe, Olaya, Sandra, Oliveira, Leandro, Oliveira, Louise Makarem, Omar, Fatma, Ononeme, Okezi, Opšenák, René, Orlandini, Simone, Osama, Alrobah, Osei-Poku, Dorcas, Osman, Haytham, Otero, Alvaro, Ottenhausen, Malte, Otzri, Shuli, Outani, Oumaima, Owusu, Emmanuel Abem, Owusu-Agyemang, Kevin, Ozair, Ahmad, Ozoner, Baris, Paal, Elli, Paiva, Mauro Sérgio, Paiva, Wellingson, Pandey, Sharad, Pansini, Gastone, Pansini, Luigi, Pantel, Tobias, Pantelas, Nikolaos, Papadopoulos, Konstantinos, Papic, Vladimir, Park, Kee, Park, Nick, Paschoal, Eric Homero Albuquerque, Paschoalino, Mylla Christie de Oliveira, Pathi, Rajesh, Peethambaran, Anilkumar, Pereira, Thiago Andrade, Perez, Irene Panero, Pérez, Claudio José Piqueras, Periyasamy, Tamilanandh, Peron, Stefano, Phillips, Michael, Picazo, Sofía Sotos, Pinar, Ertugrul, Pinggera, Daniel, Piper, Rory, Pirakash, Pathmanesan, Popadic, Branko, Posti, Jussi P., Prabhakar, Rajmohan Bhanu, Pradeepan, Sivanesalingam, Prasad, Manjunath, Prieto, Paola Calvachi, Prince, Ron, Prontera, Andrea, Provaznikova, Eva, Quadros, Danilo, Quintero, Nezly Jadid Romero, Qureshi, Mahmood, Rabiel, Happiness, Rada, Gabriel, Ragavan, Sivagnanam, Rahman, Jueria, Ramadhan, Omar, Ramaswamy, Padma, Rashid, Sakina, Rathugamage, Jagath, Rätsep, Tõnu, Rauhala, Minna, Raza, Asif, Reddycherla, Naga Raju, Reen, Linus, Refaat, Mohamed, Regli, Luca, Ren, Haijun, Ria, Antonio, Ribeiro, Thales Francisco, Ricci, Alessandro, Richterová, Romana, Ringel, Florian, Robertson, Faith, Rocha, Catarina Mayrink Siqueira Cabral, Rogério, Juvenal de Souza, Romano, Adan Anibal, Rothemeyer, Sally, Rousseau, Gail Rousseau Gail, Roza, Ranette, Rueda, Kevin David Farelo, Ruiz, Raiza, Rundgren, Malin, Rzeplinski, Radoslaw, S.Chandran, Raj, Sadayandi, Ramesh Andi, Sage, William, Sagerer, André Norbert Josef, Sakar, Mustafa, Salami, Mohcine, Sale, Danjuma, Saleh, Youssuf, Sánchez-Viguera, Cristina, Sandila, Saning'o, Sanli, Ahmet Metin, Santi, Laura, Santoro, Antonio, Santos, Aieska Kellen Dantas Dos, Santos, Samir Cezimbra dos, Sanz, Borja, Sapkota, Shabal, Sasidharan, Gopalakrishnan, Sasillo, Ibrahim, Satoskar, Rajeev, Sayar, Ali Caner, Sayee, Vignesh, Scheichel, Florian, Schiavo, Felipe Lourenzon, Schupper, Alexander, Schwarz, Andreas, Scott, Teresa, Seeberger, Esther, Segundo, Claudionor Nogueira Costa, Seidu, Anwar Sadat, Selfa, Antonio, Selmi, Nazan Has, Selvarajah, Claudiya, Şengel, Necmiye, Seule, Martin, Severo, Luiz, Shah, Purva, Shahzad, Muhammad, Shangase, Thobekile, Sharma, Mayur, Shiban, Ehab, Shimber, Emnet, Shokunbi, Temitayo, Siddiqui, Kaynat, Sieg, Emily, Siegemund, Martin, Sikder, Shahidur Rahman, Silva, Ana Cristina Veiga, Silva, Ana, Silva, Pedro Alberto, Singh, Deepinder, Skadden, Carly, Skola, Josef, Skouteli, Eirini, Słoniewski, Pawel, Smith, Brandon, Solanki, Guirish, Solla, Davi Fontoura, Solla, Davi, Sonmez, Ozcan, Sönmez, Müge, Soon, Wai Cheong, Stefini, Roberto, Stienen, Martin Nikolaus, Stoica, Bogdan, Stovell, Matthew, Suarez, Maria Natalia, Sulaiman, Alaa, Suliman, Mazin, Sulistyanto, Adi, Sulubulut, Şeniz, Sungailaite, Sandra, Surbeck, Madlen, Szmuda, Tomasz, Taddei, Graziano, Tadele, Abraham, Taher, Ahmed Saleh Ahmed, Takala, Riikka, Talari, Krishna Murthy, Tan, Bih Huei, Tariciotti, Leonardo, Tarmohamed, Murad, Taroua, Oumayma, Tatti, Emiliano, Tenovuo, Olli, Tetri, Sami, Thakkar, Poojan, Thango, Nqobile, Thatikonda, Satish Kumar, Thesleff, Tuomo, Thomé, Claudius, Thornton, Owen, Timmons, Shelly, Timoteo, Eva Ercilio, Tingate, Campbell, Tliba, Souhil, Tolias, Christos, Toman, Emma, Torres, Ivan, Torres, Luis, Touissi, Youness, Touray, Musa, Tropeano, Maria Pia, Tsermoulas, Georgios, Tsitsipanis, Christos, Turkoglu, Mehmet Erhan, Uçkun, Özhan Merzuk, Ullman, Jamie, Ungureanu, Gheorghe, Urasa, Sarah, Ur-Rehman, Obaid, Uysal, Muhammed, Vakis, Antonios, Valeinis, Egils, Valluru, Vaishali, Vannoy, Debby, Vargas, Pablo, Varotsis, Phillipos, Varshney, Rahul, Vats, Atul, Veljanoski, Damjan, Venturini, Sara, Verma, Abhijit, Villa, Clara, Villa, Genaro, Villar, Sofia, Villard, Erin, Viruez, Antonio, Voglis, Stefanos, Vulekovic, Petar, Wadanamby, Saman, Wagner, Katherine, Walshe, Rebecca, Walter, Jan, Waseem, Marriam, Whitworth, Tony, Wijeyekoon, Ruwani, Williams, Adam, Wilson, Mark, Win, Sein, Winarso, Achmad Wahib Wahju, Ximenes, Abraão Wagner Pessoa, Yadav, Anurag, Yadav, Dipak, Yakoub, Kamal Makram, Yalcinkaya, Ali, Yan, Guizhong, Yaqoob, Eesha, Yepes, Carlos, Yılmaz, Ayfer Nazmiye, Yishak, Betelehem, Yousuf, Farhat Basheer, Zahari, Muhammad Zamzuri, Zakaria, Hussein, Zambonin, Diego, Zavatto, Luca, Zebian, Bassel, Zeitlberger, Anna Maria, Zhang, Furong, Zheng, Fengwei, Ziga, Michal, Clark, David, Joannides, Alexis, Adeleye, Amos Olufemi, Bajamal, Abdul Hafid, Bashford, Tom, Biluts, Hagos, Budohoski, Karol, Ercole, Ari, Fernández-Méndez, Rocío, Figaji, Anthony, Gupta, Deepak Kumar, Härtl, Roger, Iaccarino, Corrado, Khan, Tariq, Rubiano, Andrés, Shabani, Hamisi K, Sichizya, Kachinga, Tewari, Manoj, Tirsit, Abenezer, Thu, Myat, Tripathi, Manjul, Trivedi, Rikin, Devi, Bhagavatula Indira, Servadei, Franco, Menon, David, Kolias, Angelos, and Hutchinson, Peter

Published
2022
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3. Titers of antibodies against ancestral SARS-CoV-2 correlate with levels of neutralizing antibodies to multiple variants

Author

Tran, Trung The, Vaage, Eline Benno, Mehta, Adi, Chopra, Adity, Tietze, Lisa, Kolderup, Anette, Anthi, Aina, König, Marton, Nygaard, Gro, Lind, Andreas, Müller, Fredrik, Nissen-Meyer, Lise Sofie, Magnus, Per, Trogstad, Lill, Mjaaland, Siri, Søraas, Arne, Midtvedt, Karsten, Åsberg, Anders, Barratt-Due, Andreas, Medhus, Asle W., Høivk, Marte Lie, Lundin, Knut, Karlsen, Randi Fuglaas, Dahle, Reidun, Danielsson, Karin, Thomassen, Kristine Stien, Kro, Grete Birkeland, Cox, Rebecca J., Zhou, Fan, Langeland, Nina, Aukrust, Pål, Melum, Espen, Åvitsland, Tone Lise, Wiencke, Kristine, Holter, Jan Cato, Munthe, Ludvig A., Grødeland, Gunnveig, Andersen, Jan-Terje, Vaage, John Torgils, and Lund-Johansen, Fridtjof

Published
2022
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7. Long-term outcome of patients treated for craniopharyngioma: a single center experience.

Author

Frič, Radek, König, Marton, Due-Tønnessen, Bernt J., Ramm-Pettersen, Jon, and Berg-Johnsen, Jon

Abstract

Abstract Purpose Material and method Results Conclusion Treatment of craniopharyngiomas (CP) is challenging due to their proximity to critical neural structures, risk of serious complications and impaired quality of life after treatment. Recurrences may occur many years after surgical resection. However, long-term outcome data are still scarce. The purpose of this retrospective study was therefore to assess the long-term results after treatment of patients with CP.Patients surgically treated for a histologically verified CP at Oslo University Hospital between 1992 and 2015 and with at least a 5-year follow-up were included. Patients’ medical records and radiological studies were reviewed.Sixty-one patients (mean age 35.8 ± 22.2 years) were included; 18 patients (30%) were children <18 years of age. The incidence for the study period and the referral population was 1.1 cases/million/year, with trimodal peak incidence at 6, 32 and 59 years of age. The commonest presenting symptoms were visual disturbances (62%), headache (43%) and endocrine dysfunction (34%). The transcranial approach was utilized in 79% of patients. Gross total resection (GTR) was achieved in 59%. The surgical complication rate was 20%. Three patients (5%) received radiotherapy or radiosurgery after primary resection. The mean follow-up was 139 ± 76 months, with no patients lost to follow-up. Postoperatively, 59% of patients had panhypopituitarism and 56% diabetes insipidus. Eighteen patients (30%) developed tumour recurrence after a mean follow-up of 26 ± 25 months. The 10-year overall survival (OS) rate was 75%, whereas the disease-specific survival (DSS) rate was 84%, and recurrence-free survival (RFS) 61%. Subtotal resection (STR) (p = .01) and systemic comorbidity (p = .002) were associated with worse DSS.Surgical treatment of CP, even though combined with adjuvant radiotherapy in only selected cases, provides good long-time OS and DSS, and relatively good functional outcome in long-term survivors despite postoperative morbidity, particularly endocrine dysfunction. Systemic comorbidity and STR are individual negative prognostic factors. [ABSTRACT FROM AUTHOR]

Published
2023
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8. Humoral immunity to SARS- CoV- 2 mRNA vaccination in multiple sclerosis: the relevance of time since last rituximab infusion and first experience from sporadic revaccinations.

Author

König, Marton, Lorentzen, Åslaug Rudjord, Torgauten, Hilde Marie, The Trung Tran, Schikora-Rustad, Stine, Benno Vaage, Eline, Mygland, Åse, Wergeland, Stig, Aarseth, Jan, Aaberge, Ingeborg Aase S., Torkildsen, Øivind, Holmøy, Trygve, Berge, Tone, Myhr, Kjell-Morten, Flinstad Harbo, Hanne, Andersen, Jan Terje, Munthe, Ludvig Andre, Søraas, Arne, Gulowsen Celius, Elisabeth, and Torgils Vaage, John

Subjects
HUMORAL immunity, MULTIPLE sclerosis, BOOSTER vaccines, RITUXIMAB, VACCINATION
Published
2023
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9. STA-MCA Bypass in Carotid Stenosis after Radiosurgery for Cavernous Sinus Meningioma

Author

Corniola, Marco, König, Marton, and Meling, Torstein

Subjects
Cerebral bypass, parasitic diseases, Neurosurgery, Cavernous sinus, Review, Cerebral ischemia, Meningioma, Radiosurgery, human activities, ddc:616.8
Abstract

Cavernous sinus meningiomas (CSM) are mostly non-surgical tumors. Stereotactic radiosurgery (SRS) or radiotherapy (SRT) allow tumor control and improvement of pre-existing cranial nerve (CN) deficits. We report the case of a patient with radiation-induced internal carotid artery (ICA) stenosis. We complete the picture with a review of the literature of vascular and non-vascular complications following the treatment of CSMs with SRS or SRT.

Published
2021

10. Rituximab‐treated patients with lymphoma develop strong CD8 T‐cell responses following COVID‐19 vaccination.

Author

Riise, Jon, Meyer, Saskia, Blaas, Isaac, Chopra, Adity, Tran, Trung T., Delic‐Sarac, Marina, Hestdalen, Malu Lian, Brodin, Ellen, Rustad, Even Holth, Dai, Ke‐Zheng, Vaage, John Torgils, Nissen‐Meyer, Lise Sofie Haug, Sund, Fredrik, Wader, Karin F., Bjornevik, Anne T., Meyer, Peter A., Nygaard, Gro O., König, Marton, Smeland, Sigbjørn, and Lund‐Johansen, Fridtjof

Subjects
SARS-CoV-2, COVID-19 vaccines, CD8 antigen, COVID-19, T cells
Abstract

Summary: B‐cell depletion induced by anti‐cluster of differentiation 20 (CD20) monoclonal antibody (mAb) therapy of patients with lymphoma is expected to impair humoral responses to severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) vaccination, but effects on CD8 T‐cell responses are unknown. Here, we investigated humoral and CD8 T‐cell responses following two vaccinations in patients with lymphoma undergoing anti‐CD20‐mAb therapy as single agent or in combination with chemotherapy or other anti‐neoplastic agents during the last 9 months prior to inclusion, and in healthy age‐matched blood donors. Antibody measurements showed that seven of 110 patients had antibodies to the receptor‐binding domain of the SARS‐CoV‐2 Spike protein 3–6 weeks after the second dose of vaccination. Peripheral blood CD8 T‐cell responses against prevalent human leucocyte antigen (HLA) class I SARS‐CoV‐2 epitopes were determined by peptide‐HLA multimer analysis. Strong CD8 T‐cell responses were observed in samples from 20/29 patients (69%) and 12/16 (75%) controls, with similar median response magnitudes in the groups and some of the strongest responses observed in patients. We conclude that despite the absence of humoral immune responses in fully SARS‐CoV‐2‐vaccinated, anti‐CD20‐treated patients with lymphoma, their CD8 T‐cell responses reach similar frequencies and magnitudes as for controls. Patients with lymphoma on B‐cell depleting therapies are thus likely to benefit from current coronavirus disease 2019 (COVID‐19) vaccines, and development of vaccines aimed at eliciting T‐cell responses to non‐Spike epitopes might provide improved protection. [ABSTRACT FROM AUTHOR]

Published
2022
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11. Mechanisms underlying the generation of autonomorespiratory coupling amongst the respiratory central pattern generator, sympathetic oscillators, and cardiovagal premotoneurons

Author

Ghali, Michael G. Z., Ghali, George Zaki, Lima, Adriana, McDermott, Michael, Glover, Emma, Voglis, Stefanos, Humphrey, Jennifer, König, Marton Skog Steinberger, Brem, Henry, Uhlen, Per, Spetzler, Robert F., Yasargil, M. Gazi, University of Helsinki, Department of Neurosciences, and University of Helsinki, Neurokirurgian yksikkö

Subjects
PRE-BOTZINGER COMPLEX, sympathorespiratory, CARDIAC VAGAL NEURONS, hypoxia, CHRONIC INTERMITTENT HYPOXIA, WIGNER-VILLE DISTRIBUTION, cardiovagal, 3112 Neurosciences, hypercapnia, sympathetic, 3124 Neurology and psychiatry, NUCLEUS-TRACTUS-SOLITARIUS, rostral ventrolateral medulla, modulation, BARORECEPTOR REFLEX CONTROL, nervous system, genesis, PHRENIC-NERVE DISCHARGE, Mechanisms, coupling, HIGH-FREQUENCY OSCILLATIONS, HEART-RATE VARIABILITIES
Abstract

The respiratory rhythm and pattern and sympathetic and parasympathetic outflows are generated by distinct, though overlapping, propriobulbar arrays of neuronal microcircuit oscillators constituting networks utilizing mutual excitatory and inhibitory neuronal interactions, residing principally within the metencephalon and myelencephalon, and modulated by synaptic influences from the cerebrum, thalamus, hypothalamus, cerebellum, and mesencephalon and ascending influences deriving from peripheral stimuli relayed by cranial nerve afferent axons. Though the respiratory and cardiovascular regulatory effector mechanisms utilize distinct generators, there exists significant overlap and interconnectivity amongst and between these oscillators and pathways, evidenced reciprocally by breathing modulation of sympathetic oscillations and sympathetic modulation of neural breathing. These coupling mechanisms are well-demonstrated coordinately in sympathetic- and respiratory-related central neuronal and efferent neurogram recordings and quantified by the findings of cross-correlation, spectra, and coherence analyses, combined with empirical interventions including lesioning and pharmacological agonist and antagonist microinjection studies, baroloading, barounloading, and hypoxic and/or hypercapnic peripheral and/or central chemoreceptor stimulation. Sympathetic and parasympathetic central neuronal and efferent neural discharge recordings evidence classic fast rhythms produced by propriobulbar neuronal networks located within the medullary division of the lateral tegmental field, coherent with cardiac sympathetic nerve discharge. These neural efferent nerve discharges coordinately evidence slow synchronous oscillations, constituted by Traube Hering (i.e., high frequency), Mayer wave (i.e., medium or low frequency), and vasogenic autorhythmicity (i.e., very low frequency) wave spectral bands. These oscillations contribute to coupling neural breathing, sympathetic oscillations, and parasympathetic cardiovagal premotoneuronal activity. The mechanisms underlying the origins of and coupling amongst, these waves remains to be unresolved.

Published
2020

12. The Role of Adjuvant Treatment in Craniofacial Malignancy: A Critical Review

Author

König, Marton, Osnes, Terje, Bruland, Øyvind, Sundby Hall, Kirsten, Bratland, Åse, and Meling, Torstein

Subjects
Sinonasal cancer, Neuroblastoma, Soft tissue sarcoma, Skull base malignancies, Adjuvant therapies, Malignant meningioma, Mucosal melanoma, ddc:616.8, Olfactory
Abstract

Background: Tumors originating from the craniofacial region usually present in a locally advanced stage with frequent involvement of adjacent sites and have a strong tendency for local recurrence in the absence of adjuvant therapy, even when the original surgical resection was presumed to be radical. In the past decades, several advances in the radiological diagnosis and treatment of craniofacial malignancies have been introduced. There are, however, no randomized trials that define the optimal multimodal treatment of these tumors because of their rarity as well as heterogeneity in both histology and site of origin. The aim of this study was to conduct a critical review of the role of adjuvant therapy in the treatment of craniofacial malignancy. Method: We conducted a critical review of the past and contemporary literature available, focusing on adjuvant oncological treatments of the most common craniofacial malignancies. Results: Preoperative radiotherapy can have a documented role in the treatment of olfactory neuroblastoma and soft tissue sarcoma, while preoperative chemotherapy can be advocated in the treatment of sinonasal undifferentiated carcinoma, neuroendocrine carcinoma, olfactory neuroblastoma, and craniofacial sarcoma (both soft-tissue and high-grade osteosarcoma). Postoperative radiotherapy has a well-established role in the treatment of most craniofacial malignancies. The role of postoperative chemotherapy is unclear in most histologies, but is commonly used during the treatment of well-selected cases of paranasal sinus carcinoma, olfactory neuroblastoma, mucosal melanoma, soft tissue sarcoma and high-grade craniofacial osteosarcoma. Discussion: Alongside developments in surgery, there have also been improvements in diagnostics, radiotherapy, and chemotherapy. Implementation of novel radiation techniques allows delivery of higher radiation doses while minimizing irradiation-related morbidity. Better understanding of tumor biology allows the construction of more complex treatment strategies, incorporating adjuvant chemotherapy either pre- or postoperatively. In the era of personalized targeted therapy, rapid strides are being made to identify specific tumor-targets for use of novel biologic agents, with the potential to change current management paradigms.

Published
2020

16. Squamous Cell Carcinoma of the Paranasal Sinuses: A Single Center Experience.

Author

König, Marton, Osnes, Terje, Bratland, Åse, and Meling, Torstein R.

Subjects
*SQUAMOUS cell carcinoma, *PROGNOSIS, *SURGICAL excision, *ONCOLOGIC surgery, *PALLIATIVE treatment, *PARANASAL sinuses
Abstract

Objective  Squamous cell carcinoma (SCC) of the paranasal sinuses is usually diagnosed at an advanced stage, making curative therapy difficult. The goal of this study was to evaluate the management and outcomes of patients with SCC treated at our institution. Methods  In a population-based consecutive prospective cohort, we conducted an analysis of all patients treated for SCC between 1988 and 2017. Results  A total of 72 patients were included, follow-up was 100%. Mean follow-up was 57 months for the entire cohort, and 108 months for patients with no evidence of disease. Eighty-two percent of all patients had high-stage (T4) disease. Fifty-seven patients underwent treatment with curative intent; consisting of surgery with or without oncologic treatment in 34, and of oncologic treatment only in 23 cases. Fifteen patients received palliative treatment. The rates of overall survival for the entire cohort were 55% at 2, 41% at 5, and 32% at 10 years, and corresponding disease-specific survival (DSS) rates were 55, 45, and 34%, respectively. DSS rates after surgical treatment with curative intent were 81% at 2, 65% at 5, and 54% at 10 years. Retromaxillary involvement and nonradical surgery were negative prognostic factors. Best survival was achieved with the combination of radical surgery and adjuvant oncologic treatment. Conclusion  Surgical resection with a curative intent yielded 65% at 5-year DSS even in this cohort of patients with high-stage SCC and is still considered as the treatment of choice, preferably in combination with adjuvant radiation therapy and chemotherapy. [ABSTRACT FROM AUTHOR]

Published
2020
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17. Treatment of Sinonasal Adenocarcinoma: A Population-Based Prospective Cohort Study.

Author

König, Marton, Osnes, Terje, Bratland, Åse, Jebsen, Peter, and Meling, Torstein R.

Subjects
*PROGNOSIS, *SURVIVAL analysis (Biometry), *COHORT analysis, *LONGITUDINAL method, *ADENOCARCINOMA, *RADIOISOTOPE brachytherapy, *FACIAL pain
Abstract

Objectives  Sinonasal adenocarcinoma (AC) is a potentially curable disease despite being an aggressive malignancy. Long-term survival can be achieved with early diagnosis and adequate multidisciplinary treatment. Our goal was to evaluate outcomes for patients with AC treated at our institution. Design  In a population-based consecutive prospective cohort, we conducted an analysis of all patients treated for surface epithelial AC between 1995 and 2018. Results  Twenty patients were included, and follow-up was 100%. The mean follow-up time was 89 months for the entire cohort (112 months for patients with no evidence of disease). Intestinal-type AC was found in 65%, whereas nonintestinal-type AC was found in 35% of all cases; 75% had stage T3/4 disease. Tumor grade was intermediate/high in 65%. Eighteen patients underwent treatment with curative intent (craniofacial resection [CFR] in 61%, transfacial approach in 39%, adjuvant radiotherapy in 89%), achieving negative margins in 56% of cases. Overall survival (OS) rates were 90, 68, and 54% after 2, 5, and 10 years of follow-up, respectively, and the corresponding disease-specific survival (DSS) rates were 90, 73, and 58%. Age over 60 years, tumor with a maxillary origin, and microscopic bone invasion were negative prognostic factors. Radical CFR was correlated with better OS and DSS. Conclusion  The high probability of achieving radicality with CFR, the low complication rate, the acceptable toxicity of modern irradiation modalities, and the promising survival rates indicate that this strategy might be considered a safe and an effective option for treating patients with very advanced sinonasal AC. [ABSTRACT FROM AUTHOR]

Published
2020
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19. Olfactory neuroblastoma: a single-center experience.

Author

König, Marton, Osnes, Terje, Jebsen, Peter, Evensen, Jan Folkvard, and Meling, Torstein R.

Subjects
*OLFACTORY esthesioneuroblastoma, *HEAD & neck cancer treatment, *NEUROBLASTOMA, *NATURAL history, *MEDICAL registries, *LONGITUDINAL method, *THERAPEUTICS
Abstract

Olfactory neuroblastoma (ONB) is a potentially curable disease, despite being an aggressive malignancy with a poor natural history. Our goal was to evaluate management outcomes for patients with ONB treated at our institution. Our prospective database for brain tumors and the pathology registry of head and neck cancers at Oslo University Hospital were searched to identify all patients treated for ONB between 1998 and 2016. Variables extracted from these databases, supplemented by retrospective chart reviews, underwent thorough analysis. All cases were formally re-examined by a dedicated head and neck pathologist. Twenty patients were identified. Follow-up was 100%. Mean follow-up was 81.5 months for the entire cohort and 120.3 months for patients with no evidence of disease. Fourteen patients underwent treatment of choice including craniofacial resection (CFR) with or without radiotherapy (XRT). Six patients could only receive less extensive treatment; three patients underwent lateral rhinotomy (LR) with or without XRT after being deemed medically unsuitable for CFR, while another three patients received only supportive, non-surgical treatment (due to positive lymph node status in two and to extensive tumor size in one case). Overall and disease-specific survival rates were 100% after 10 years of follow-up when negative surgical margins were achieved by CFR. Positive margins were associated with poorer outcome with no patients surviving longer than 44 months. Long-term survival was also achieved in two cases among patients not eligible for CFR: one case after radical LR and one case after radio-chemotherapy. Advanced disease at presentation (tumor size ≥40 mm, Kadish grades C and D, or TNM IVa and IVb) and positive surgical margins were correlated to significantly dismal survival. Our study suggests that CFR with or without adjuvant XRT is safe and leads to excellent long-time overall and disease-specific survival. Negative surgical margins, tumor size <40 mm, Kadish stage A/B, and TNM stages I-III are independent prognostic predictors of outcome. [ABSTRACT FROM AUTHOR]

Published
2018
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22. T cell responses to SARS-CoV-2 vaccination differ by disease-modifying therapy for multiple sclerosis.

Author

Wolf AS, Ravussin A, König M, Øverås MH, Solum G, Kjønstad IF, Chopra A, Holmøy T, Harbo HF, Syversen SW, Jørgensen KK, Høgestøl EA, Vaage JT, Celius EG, Lund-Johansen F, Munthe LA, Nygaard GO, and Mjaaland S

Subjects
Humans, COVID-19 Vaccines, Fingolimod Hydrochloride therapeutic use, Pandemics, Rituximab, SARS-CoV-2, Vaccination, Multiple Sclerosis drug therapy, COVID-19
Abstract

Immune responses in people with multiple sclerosis (pwMS) receiving disease-modifying therapies (DMTs) have been of significant interest throughout the COVID-19 pandemic. Lymphocyte-targeting immunotherapies, including anti-CD20 treatments and sphingosine-1-phosphate receptor (S1PR) modulators, attenuate Ab responses after vaccination. Evaluation of cellular responses after vaccination, therefore, is of particular importance in these populations. In this study, we used flow cytometry to analyze CD4 and CD8 T cell functional responses to SARS-CoV-2 spike peptides in healthy control study participants and pwMS receiving 5 different DMTs. Although pwMS receiving rituximab and fingolimod therapies had low Ab responses after both 2 and 3 vaccine doses, T cell responses in pwMS taking rituximab were preserved after a third vaccination, even when an additional dose of rituximab was administered between vaccine doses 2 and 3. PwMS taking fingolimod had low detectable T cell responses in peripheral blood. CD4 and CD8 T cell responses to SARS-CoV-2 variants of concern Delta and Omicron were lower than to the ancestral Wuhan-Hu-1 variant. Our results indicate the importance of assessing both cellular and humoral responses after vaccination and suggest that, even in the absence of robust Ab responses, vaccination can generate immune responses in pwMS.

Published
2023
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23. A man in his twenties with weakness and numbness in his legs.

Author

Hermansen MV, Kleggetveit IP, Ulvin LB, Chawla MS, and König M

Subjects
Male, Humans, Leg, Hypesthesia etiology
Abstract

Neuropathy can have many causes, some less well known than others. In this article, we present the case of a young man with progressive neurological deficit over several months. The cause was found to be an increasing social problem.

Published
2022
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25. Retraction: Ghali MGZ, et al . Mechanisms underlying the generation of autonomorespiratory coupling amongst the respiratory central pattern generator, sympathetic oscillators, and cardiovagal premotoneurons. Journal of Integrative Neuroscience. 2020; 19: 521-560.

Author

Ghali MGZ, Ghali GZ, Lima A, McDermott M, Glover E, Voglis S, Humphrey J, König MSS, Brem H, Uhlén P, Spetzler RF, and Yasargil MG

Abstract

No abstract present., (© 2021 The Author(s). Published by IMR Press.)

Published
2021
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26. STA-MCA Bypass in Carotid Stenosis after Radiosurgery for Cavernous Sinus Meningioma.

Author

Corniola MV, König M, and Meling TR

Abstract

Background: Cavernous sinus meningiomas (CSM) are mostly non-surgical tumors. Stereotactic radiosurgery (SRS) or radiotherapy (SRT) allow tumor control and improvement of pre-existing cranial nerve (CN) deficits. We report the case of a patient with radiation-induced internal carotid artery (ICA) stenosis. We complete the picture with a review of the literature of vascular and non-vascular complications following the treatment of CSMs with SRS or SRT., Methods: After a case description, a systematic literature review is presented, according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2015 guidelines., Results: 115 abstracts were screened and 70 titles were retained for full-paper screening. A total of 58 articles did not meet the inclusion criteria. There were 12 articles included in our review, with a follow-up ranging from 33 to 120 months. Two cases of post-SRT ischemic stroke and one case of asymptomatic ICA stenosis were described. Non-vascular complications were reported in all articles., Conclusion: SRS and SRT carry fewer complications than open surgery, with similar rates of tumor control. Our case shows the importance of a follow-up of irradiated CSMs not only by a radio-oncologist, but also by a neurosurgeon, illustrating the importance of multidisciplinary management of CSMs.

Published
2021
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27. Mechanisms underlying the generation of autonomorespiratory coupling amongst the respiratory central pattern generator, sympathetic oscillators, and cardiovagal premotoneurons.

Author

Ghali MGZ, Ghali GZ, Lima A, McDermott M, Glover E, Voglis S, Humphrey J, König MSS, Brem H, Uhlén P, Spetzler RF, and Yasargil MG

Subjects
Animals, Humans, Neural Pathways physiology, Respiratory Center, Brain physiology, Cardiovascular Physiological Phenomena, Central Pattern Generators physiology, Neurons physiology, Respiration, Sympathetic Nervous System
Abstract

The respiratory rhythm and pattern and sympathetic and parasympathetic outflows are generated by distinct, though overlapping, propriobulbar arrays of neuronal microcircuit oscillators constituting networks utilizing mutual excitatory and inhibitory neuronal interactions, residing principally within the metencephalon and myelencephalon, and modulated by synaptic influences from the cerebrum, thalamus, hypothalamus, cerebellum, and mesencephalon and ascending influences deriving from peripheral stimuli relayed by cranial nerve afferent axons. Though the respiratory and cardiovascular regulatory effector mechanisms utilize distinct generators, there exists significant overlap and interconnectivity amongst and between these oscillators and pathways, evidenced reciprocally by breathing modulation of sympathetic oscillations and sympathetic modulation of neural breathing. These coupling mechanisms are well-demonstrated coordinately in sympathetic- and respiratory-related central neuronal and efferent neurogram recordings and quantified by the findings of cross-correlation, spectra, and coherence analyses, combined with empirical interventions including lesioning and pharmacological agonist and antagonist microinjection studies, baroloading, barounloading, and hypoxic and/or hypercapnic peripheral and/or central chemoreceptor stimulation. Sympathetic and parasympathetic central neuronal and efferent neural discharge recordings evidence classic fast rhythms produced by propriobulbar neuronal networks located within the medullary division of the lateral tegmental field, coherent with cardiac sympathetic nerve discharge. These neural efferent nerve discharges coordinately evidence slow synchronous oscillations, constituted by Traube Hering (i.e., high frequency), Mayer wave (i.e., medium or low frequency), and vasogenic autorhythmicity (i.e., very low frequency) wave spectral bands. These oscillations contribute to coupling neural breathing, sympathetic oscillations, and parasympathetic cardiovagal premotoneuronal activity. The mechanisms underlying the origins of and coupling amongst, these waves remains to be unresolved., Competing Interests: All authors declare no conflicts of interest., (© 2020 Ghali et al. Published by IMR press.)

Published
2020
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29. The Role of Adjuvant Treatment in Craniofacial Malignancy: A Critical Review.

Author

König M, Osnes T, Bruland Ø, Sundby Hall K, Bratland Å, and Meling TR

Abstract

Background: Tumors originating from the craniofacial region usually present in a locally advanced stage with frequent involvement of adjacent sites and have a strong tendency for local recurrence in the absence of adjuvant therapy, even when the original surgical resection was presumed to be radical. In the past decades, several advances in the radiological diagnosis and treatment of craniofacial malignancies have been introduced. There are, however, no randomized trials that define the optimal multimodal treatment of these tumors because of their rarity as well as heterogeneity in both histology and site of origin. The aim of this study was to conduct a critical review of the role of adjuvant therapy in the treatment of craniofacial malignancy. Method: We conducted a critical review of the past and contemporary literature available, focusing on adjuvant oncological treatments of the most common craniofacial malignancies. Results: Preoperative radiotherapy can have a documented role in the treatment of olfactory neuroblastoma and soft tissue sarcoma, while preoperative chemotherapy can be advocated in the treatment of sinonasal undifferentiated carcinoma, neuroendocrine carcinoma, olfactory neuroblastoma, and craniofacial sarcoma (both soft-tissue and high-grade osteosarcoma). Postoperative radiotherapy has a well-established role in the treatment of most craniofacial malignancies. The role of postoperative chemotherapy is unclear in most histologies, but is commonly used during the treatment of well-selected cases of paranasal sinus carcinoma, olfactory neuroblastoma, mucosal melanoma, soft tissue sarcoma and high-grade craniofacial osteosarcoma. Discussion: Alongside developments in surgery, there have also been improvements in diagnostics, radiotherapy, and chemotherapy. Implementation of novel radiation techniques allows delivery of higher radiation doses while minimizing irradiation-related morbidity. Better understanding of tumor biology allows the construction of more complex treatment strategies, incorporating adjuvant chemotherapy either pre- or postoperatively. In the era of personalized targeted therapy, rapid strides are being made to identify specific tumor-targets for use of novel biologic agents, with the potential to change current management paradigms., (Copyright © 2020 König, Osnes, Bruland, Sundby Hall, Bratland and Meling.)

Published
2020
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30. What would Winnie the Pooh have said?

Author

König M

Subjects
Foreign Medical Graduates statistics & numerical data, Humans, Norway, Education, Medical organization & administration, Health Workforce, Physicians supply & distribution
Published
2019
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31. Multimodal treatment of osteogenic sarcoma of the jaw.

Author

König M, Mork J, Hall KS, Osnes T, and Meling TR

Abstract

Osteosarcomas (OSs) account for 40 to 60% of primary malignant bone tumors. About 10% occur in the head and neck region, frequently in the mandibula or maxilla. We treated a 30-year-old patient with 26-month history of right-sided facial pain and paresthesia. Investigation showed high-grade OS of the right mandibular coronoid process, affecting the mandibular nerve, middle cranial fossa, internal jugular vein, and internal carotid artery (ICA). True en bloc resection was performed after upfront adjuvant chemotherapy. The ICA was trap-ligated intradurally, whereafter the floor of the middle fossa, including the mandibular nerve and the glenoid fossa, was detached from the skull base in one piece. Subsequently, a hemimandibulectomy, total parotidectomy, ICA sacrifice, and removal of the pterygoid plates and muscles were performed, and the abovementioned structures were removed as a solitary specimen, including the facial nerve branches overlying the tumor. A sural nerve graft was interposed between five major facial nerve branches to reanimate the face. The patient had an uneventful recovery, is able to eat, and has a partial facial nerve palsy. He has no tumor recurrence 26 months after surgery. OS of the jaw should be treated with radical surgery as the primary modality.

Published
2010
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32. Median facial cleft with a frontoethmoidal encephalocele treated with craniofacial bipartition and free radial forearm flap: a case report.

Author

König M, Due-Tønnessen B, Osnes T, Haugstvedt JR, and Meling TR

Abstract

We describe a patient with a median facial cleft with a frontoethmoidal encephalocele, hypertelorism, hydrocephalus, and cerebrospinal fluid (CSF) leakage referred to our department due to numerous complications after previous surgical treatments. An 8-year-old girl, born with median cleft syndrome, underwent neurosurgical repair of the encephalocele at another hospital and cleft lip/palate repair later in the same year. Her hydrocephalus was treated with a ventriculoperitoneal shunt, but she underwent numerous shunt revisions due to recurrent intracerebral infections. In 2008, she was rehospitalized due to a gram-negative meningitis and cerebral abscess. She underwent surgery where part of her frontal bone was removed due to osteomyelitis. She was referred to our department due to persistent CSF leakage, recurrent infections, and significant dura defect. In addition, she had hypertelorism and a strongly reduced vision. We performed a monobloc and facial bipartition osteotomy where 15 mm of her frontal and nasal bone was removed after facial bipartiton. The dura defect was closed using a free fasciocutanous flap. The patient had no CSF leakage or infections postoperatively, and her hypertelorism was reduced. The case represents the first monobloc and facial bipartition osteotomy performed in Norway as a part of the treatment of median cleft syndrome with a nasoethmoidal encephalocele.

Published
2010
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