34 results on '"Jungert, Alexandra"'
Search Results
2. Intraoral scanner-based monitoring of tooth wear in young adults: 12-month results
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Schlenz, Maximiliane Amelie, Schlenz, Moritz Benedikt, Wöstmann, Bernd, Jungert, Alexandra, and Ganss, Carolina
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- 2022
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3. Revised D-A-CH Reference Values for the Intake of Vitamin B₆
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Jungert, Alexandra, Linseisen, Jakob, Wagner, Karl-Heinz, and Richter, Margrit
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- 2020
4. Correction to: Revised D-A-CH reference values for the intake of biotin
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Jungert, Alexandra, Ellinger, Sabine, Watzl, Bernhard, and Richter, Margrit
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- 2022
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5. Predictors of serum cobalamin and its association with homocysteine in community-dwelling older adults
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Jungert, Alexandra and Neuhäuser-Berthold, Monika
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- 2019
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6. Dynamics and interactions of cobalamin and folate status during advanced aging – a longitudinal study in a community-dwelling cohort with multiple follow-ups
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Jungert, Alexandra, Zenke-Philippi, Carola, and Neuhäuser-Berthold, Monika
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- 2020
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7. Dietary vitamin D intake is not associated with 25-hydroxyvitamin D3 or parathyroid hormone in elderly subjects, whereas the calcium-to-phosphate ratio affects parathyroid hormone
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Jungert, Alexandra and Neuhäuser-Berthold, Monika
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- 2013
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8. The Suitability of Questionnaires for Exploring Relations of Dietary Behavior and Tooth Wear
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Schlenz, Maximiliane Amelie, Schlenz, Moritz Benedikt, Wöstmann, Bernd, Jungert, Alexandra, Glatt, Anna Sophia, Ganss, Carolina, and Justus Liebig University Giessen
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ddc:610 - Published
- 2022
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9. Vitamin Substitution Beyond Childhood—Requirements and Risks
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Jungert, Alexandra, Quack Lötscher, Katharina, Rohrmann, Sabine, University of Zurich, and Rohrmann, Sabine
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610 Medicine & health ,10060 Epidemiology, Biostatistics and Prevention Institute (EBPI) ,2700 General Medicine ,10026 Clinic for Obstetrics - Published
- 2020
10. Interrelation between Plasma Concentrations of Vitamins C and E along the Trajectory of Ageing in Consideration of Lifestyle and Body Composition: A Longitudinal Study over Two Decades
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Jungert, Alexandra, Neuhäuser-Berthold, Monika, and Justus Liebig University Giessen
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ddc:640 ,ddc:360 - Published
- 2020
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11. Serum 25-hydroxyvitamin D3 and body composition in an elderly cohort from Germany: a cross-sectional study
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Jungert Alexandra, Roth Heinz J, and Neuhäuser-Berthold Monika
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25-Hydroxyvitamin D3 ,Body composition ,Fat mass ,Elderly ,Nutrition. Foods and food supply ,TX341-641 ,Nutritional diseases. Deficiency diseases ,RC620-627 - Abstract
Abstract Background Emerging evidence indicates that there is an association between vitamin D and obesity. The aim of this study was to investigate whether the level of serum 25-hydroxyvitamin D3 [25(OH)D3] in the elderly is influenced by parameters of anthropometry and body composition independent of potential confounding lifestyle factors and the level of serum intact parathyroid hormone (iPTH). Methods Cross-sectional data of 131 independently living participants (90 women, 41 men; aged 66–96 years) of the longitudinal study on nutrition and health status in senior citizens of Giessen, Germany were analysed. Concentrations of 25(OH)D3 and iPTH were ascertained by an electrochemiluminescence immunoassay. Body composition was measured by a bioelectrical impedance analysis. We performed univariate and multiple regression analyses to examine the influence of body composition on 25(OH)D3 with adjustments for age, iPTH and lifestyle factors. Results In univariate regression analyses, 25(OH)D3 was associated with body mass index (BMI), hip circumference and total body fat (TBF) in women, but not in men. Using multiple regression analyses, TBF was shown to be a negative predictor of 25(OH)D3 levels in women even after controlling for age, lifestyle and iPTH (ß = −0.247; P = 0.016), whereas the associations between BMI, hip circumference and 25(OH)D3 lost statistical significance after adjusting for iPTH. In men, 25(OH)D3 was not affected by anthropometric or body composition variables. Conclusions The results indicate that 25(OH)D3 levels are affected by TBF, especially in elderly women, independent of lifestyle factors and iPTH.
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- 2012
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12. Serum 25-hydroxyvitamin D3, parathyroid hormone and blood pressure in an elderly cohort from Germany: a cross-sectional study
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Jungert Alexandra, Roth Heinz J, and Neuhäuser-Berthold Monika
- Subjects
25-Hydroxyvitamin D3 ,Parathyroid hormone ,Blood pressure ,Elderly ,Nutrition. Foods and food supply ,TX341-641 ,Nutritional diseases. Deficiency diseases ,RC620-627 - Abstract
Abstract Background Although several studies indicate a link between vitamin D status and blood pressure (BP), the results are inconsistent. The purpose of this study is to investigate whether in predominantly non-obese elderly people without vitamin D deficiency or very high intact parathyroid hormone (iPTH) levels serum 25-hydroxyvitamin D3 [25(OH)D3] and iPTH are independently associated with BP. Methods Cross-sectional data of 132 non-institutionalised subjects (90 women and 42 men, aged 66- 96 years) from Giessen, Germany, were analysed. Serum 25(OH)D3 and iPTH were measured by an electrochemiluminescence immunoassay and BP was determined with a sphygmomanometer. We performed univariate and multiple regression analyses to examine the influence of 25(OH)D3 and iPTH on BP with adjustments for age, body composition and lifestyle factors. Results While iPTH had no impact on BP, 25(OH)D3 was negatively associated with systolic BP in men, but not in women. After splitting the cohort into antihypertensive medication users and non-users, 25(OH)D3 was a significant predictor for systolic and diastolic BP only in men not receiving antihypertensive medicine, even after multiple adjustment. Adjustment for 25(OH)D3 resulted in an inverse association of iPTH with diastolic BP also only in men without intake of antihypertensive medicine. Conclusions In elderly men without vitamin D deficiency and not taking antihypertensive medicine, 25(OH)D3 may be a negative determinant of BP, independent of iPTH, body composition and lifestyle factors. Furthermore, iPTH may be an independent negative determinant of diastolic BP in men not taking antihypertensive medicine.
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- 2012
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13. Dietary intake and main food sources of vitamin D as a function of age, sex, vitamin D status, body composition, and income in an elderly German cohort
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Jungert, Alexandra, Spinneker, Andre, Nagel, Anja, Neuhäuser-Berthold, Monika, and Institute of Nutritional Science
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body composition ,food sources ,fish consumption ,lcsh:TX341-641 ,Home economics & family living ,25-hydroxyvitamin D ,Human nutrition ,diet ,Elderly subjects, Vitamin D ,ddc:640 ,Original Article ,Human Nutrition ,Food Related Nutrition ,Public Health Nutrition ,lcsh:Nutrition. Foods and food supply - Abstract
Background: Elderly subjects are at risk of insufficient vitamin D status mainly because of diminished capacity for cutaneous vitamin D synthesis. In cases of insufficient endogenous production, vitamin D status depends on vitamin D intake.Objective: The purpose of this study is to identify the main food sources of vitamin D in elderly subjects and to analyse whether contributing food sources differ by sex, age, vitamin D status, body mass index (BMI), or household income. In addition, we analysed the factors that influence dietary vitamin D intake in the elderly.Design and subjects: This is a cross-sectional study in 235 independently living German elderly aged 66–96 years (BMI=27±4 kg/m2). Vitamin D intake was assessed by a 3-day estimated dietary record.Results: The main sources of dietary vitamin D were fish/fish products followed by eggs, fats/oils, bread/bakery products, and milk/dairy products. Differences in contributing food groups by sex, age, vitamin D status, and BMI were not found. Fish contributed more to vitamin D intake in subjects with a household income of
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- 2014
14. Riboflavin Is an Important Determinant of Vitamin B-6 Status in Healthy Adults.
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Jungert, Alexandra, McNulty, Helene, Hoey, Leane, Ward, Mary, Strain, J J, Hughes, Catherine F, McAnena, Liadhan, Neuhäuser-Berthold, Monika, and Pentieva, Kristina
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VITAMIN B2 , *VITAMINS , *METHYLENETETRAHYDROFOLATE reductase , *MULTIPLE regression analysis , *OLDER people , *GLUTATHIONE reductase , *AGE groups , *LIFESTYLES , *RESEARCH , *VITAMIN B6 , *RESEARCH methodology , *DIET , *EVALUATION research , *MEDICAL cooperation , *VITAMIN B complex , *COMPARATIVE studies , *HEALTH of older people - Abstract
Background: Riboflavin is required to generate the active form of vitamin B-6 (pyridoxal 5'-phosphate; PLP) in tissues, but the relevance of this metabolic interaction for nutritional status of vitamin B-6 is unclear because riboflavin biomarkers are rarely measured in human studies.Objectives: The purpose of this study was to identify the determinants of biomarkers of vitamin B-6 and riboflavin status and to examine the relationship between these nutrients in healthy adults.Methods: Multiple linear regression was performed on observational data in 407 healthy adults aged 18-92 y who did not use B-vitamin supplements. Vitamin B-6 status was assessed by plasma PLP concentrations and erythrocyte glutathione reductase activation coefficient (EGRac) was used as a functional indicator of riboflavin status.Results: Dietary intakes of vitamin B-6 and riboflavin were below the average requirements in 10% and 29% of participants, respectively. Suboptimal status of vitamin B-6 (PLP ≤30.0 nmol/L) was more prevalent in adults aged ≥60 y than in younger participants (i.e., 14% compared with 5%), whereas a high proportion (i.e., overall 37%) of both age groups had deficient riboflavin status (EGRac ≥1.40). In multiple regression analysis, EGRac (P = 0.019) was a significant determinant of plasma PLP, along with dietary vitamin B-6 intake (P = 0.003), age (P < 0.001), BMI (kg/m2) (P = 0.031), and methylenetetrahydrofolate reductase gene (MTHFR) genotype (P < 0.001). Significant determinants of EGRac were dietary riboflavin intake (P < 0.001), age (P < 0.001) and MTHFR genotype (P = 0.020). Plasma PLP showed a stepwise decrease across riboflavin status categories from optimal (EGRac ≤1.26) to low (EGRac 1.27-1.39) to deficient status (P = 0.001), independent of dietary vitamin B-6 intake.Conclusions: The findings are consistent with the known metabolic dependency of vitamin B-6 on riboflavin status and indicate that riboflavin may be the limiting nutrient, particularly in older people, for maintaining adequate vitamin B-6 status. [ABSTRACT FROM AUTHOR]- Published
- 2020
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15. Revised D-A-CH Reference Values for the Intake of Vitamin B6.
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Jungert, Alexandra, Linseisen, Jakob, Wagner, Karl-Heinz, and Richter, Margrit
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BIOMARKERS , *DIETARY supplements , *INGESTION , *NUTRITIONAL requirements , *VITAMIN B6 - Abstract
Background: The Nutrition Societies of Germany, Austria, and Switzerland as the joint editors of the "D-A-CH reference values for nutrient intake" have revised the reference values for vitamin B6 in summer 2019. Summary: For women, the average requirement (AR) for vitamin B6 intake was derived on the basis of balance studies using a pyridoxal-5′-phosphate (PLP) plasma concentration of ≥30 nmol/L as a biomarker of an adequate vitamin B6 status. The recommended intake (RI) was derived considering a coefficient of variation of 10%. The RIs of vitamin B6 for men, children, and adolescents were extrapolated from the vitamin B6 requirement for women considering differences in body weight, an allometric exponent, growth factors as appropriate, and a coefficient of variation. For infants aged 0 to under 4 months, an estimated value was set based on the vitamin B6 intake via breast feeding. The reference value for infants aged 4 to under 12 months was extrapolated from the estimated value for infants under 4 months of age and the average vitamin B6 requirement for adults. The reference values for pregnant and lactating women consider the requirements for the foetus and the loss via breast milk. Key Messages: According to the combined analysis of 5 balance studies, the AR for vitamin B6 to ensure a plasma PLP concentration of ≥30 nmol/L is 1.2 mg/day for adult females and the extrapolated AR for adult males is 1.3 mg/day. The corresponding RIs of vitamin B6 are 1.4 mg/day for adult females and 1.6 mg/day for adult males, independent of age. For infants, the estimated value is 0.1 mg/day and 0.3 mg/day, depending on age. The AR of vitamin B6 for children and adolescents ranges between 0.5 and 1.5 mg/day, and the RI is between 0.6 mg/day and 1.6 mg/day. During pregnancy, the AR is 1.3 mg/day in the first trimester and 1.5 mg/day in the second and third trimesters; the RI is 1.5 mg/day in the first trimester and 1.8 mg/day in the second and third trimesters. For lactating women, the AR is 1.3 mg/day and the RI is 1.6 mg/day. [ABSTRACT FROM AUTHOR]
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- 2020
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16. Revised D-A-CH Reference Values for the Intake of Vitamin B6.
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Jungert, Alexandra, Linseisen, Jakob, Wagner, Karl-Heinz, and Richter, Margrit
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BIOMARKERS ,DIETARY supplements ,INGESTION ,NUTRITIONAL requirements ,VITAMIN B6 - Abstract
Background: The Nutrition Societies of Germany, Austria, and Switzerland as the joint editors of the "D-A-CH reference values for nutrient intake" have revised the reference values for vitamin B
6 in summer 2019. Summary: For women, the average requirement (AR) for vitamin B6 intake was derived on the basis of balance studies using a pyridoxal-5′-phosphate (PLP) plasma concentration of ≥30 nmol/L as a biomarker of an adequate vitamin B6 status. The recommended intake (RI) was derived considering a coefficient of variation of 10%. The RIs of vitamin B6 for men, children, and adolescents were extrapolated from the vitamin B6 requirement for women considering differences in body weight, an allometric exponent, growth factors as appropriate, and a coefficient of variation. For infants aged 0 to under 4 months, an estimated value was set based on the vitamin B6 intake via breast feeding. The reference value for infants aged 4 to under 12 months was extrapolated from the estimated value for infants under 4 months of age and the average vitamin B6 requirement for adults. The reference values for pregnant and lactating women consider the requirements for the foetus and the loss via breast milk. Key Messages: According to the combined analysis of 5 balance studies, the AR for vitamin B6 to ensure a plasma PLP concentration of ≥30 nmol/L is 1.2 mg/day for adult females and the extrapolated AR for adult males is 1.3 mg/day. The corresponding RIs of vitamin B6 are 1.4 mg/day for adult females and 1.6 mg/day for adult males, independent of age. For infants, the estimated value is 0.1 mg/day and 0.3 mg/day, depending on age. The AR of vitamin B6 for children and adolescents ranges between 0.5 and 1.5 mg/day, and the RI is between 0.6 mg/day and 1.6 mg/day. During pregnancy, the AR is 1.3 mg/day in the first trimester and 1.5 mg/day in the second and third trimesters; the RI is 1.5 mg/day in the first trimester and 1.8 mg/day in the second and third trimesters. For lactating women, the AR is 1.3 mg/day and the RI is 1.6 mg/day. [ABSTRACT FROM AUTHOR]- Published
- 2020
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17. Determinants of Vitamin B6 Status in Community-Dwelling Older Adults: A Longitudinal Study Over a Period of 18 Years.
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Jungert, Alexandra and Neuhäuser-Berthold, Monika
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VITAMIN B6 , *BODY composition , *LONGITUDINAL method , *HIGH performance liquid chromatography , *OLDER people , *LIFESTYLES , *RESEARCH , *ANTHROPOMETRY , *RESEARCH methodology , *EVALUATION research , *MEDICAL cooperation , *COMPARATIVE studies , *INDEPENDENT living - Abstract
Background: Cross-sectional studies indicate an age-related decline in vitamin B6 status. Because longitudinal studies are lacking, the present study investigates the long-term association between age and vitamin B6 status in older adults by considering potential confounding factors.Methods: The study population consists of 249 women and 111 men aged ≥ 60 years, who had at least three follow-ups between 1996 and 2014 with complete data records on relevant parameters. Vitamin B6 status was assessed by serum pyridoxal 5'-phosphate (PLP) concentrations measured by high-performance liquid chromatography. Linear mixed models were used to analyze the influence of age, sex, body composition, supplements, diet, lifestyle, and serum creatinine on PLP concentrations.Results: At baseline, 37% of the subjects showed PLP concentrations < 30 nmol/L and more than half failed to meet the recommended dietary intake. Longitudinal analyses revealed that age, use of supplements and protein intake were positive determinants of PLP concentrations, whereas body fat showed a negative impact. No influence of sex, dietary vitamin B6 intake, lifestyle factors or serum creatinine on PLP concentrations was found.Conclusion: The present study provides no evidence that in the course of aging PLP concentrations decline between 60 and 90 years. However, age-related changes in body composition, such as an increased ratio of fat mass to fat-free mass may negatively affect vitamin B6 status. [ABSTRACT FROM AUTHOR]- Published
- 2020
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18. Sex-specific determinants of serum 25-hydroxyvitamin D3 concentrations in an elderly German cohort : a cross-sectional study
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Jungert, Alexandra, Neuhäuser-Berthold, Monika, and Institute of Nutritional Science
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lifestyle ,body composition ,Nutrition and Dietetics ,Endocrinology, Diabetes and Metabolism ,Medicine (miscellaneous) ,determinants ,ddc:610 ,diet ,25-hydroxyvitamin D ,Medical sciences Medicine - Abstract
BACKGROUND: Considering the suggested link between vitamin D insufficiency and several chronic diseases, attention should be given to approaches for improving vitamin D status. Elderly subjects are regarded as a high-risk group for developing an insufficient vitamin D status. Socioeconomic, dietary, lifestyle and environmental factors are considered as influencing factors, whereupon sex differences in predictors of vitamin D status are rarely investigated. The purpose of this study is to identify the main predictors of serum 25-hydroxyvitamin D3 [25(OH)D3] concentrations in elderly subjects by taking into account potential sex differences. METHODS: This is a cross-sectional study in 162 independently living German elderly aged 66 to 96years. Serum 25(OH)D3 concentrations were assessed by an electrochemiluminescence immunoassay. Multiple regression analyses were performed to identify predictors of 25(OH)D3 concentrations stratified by sex. RESULTS:Median 25(OH)D3 concentration was 64nmol/L and none of the subjects had 25(OH)D3 concentrations
- Published
- 2015
19. Cross-sectional and longitudinal associations between serum 25‑hydroxyvitamin D and anti-oxidative status in older adults.
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Jungert, Alexandra and Neuhäuser-Berthold, Monika
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GLUTATHIONE peroxidase , *OXIDATIVE stress , *VITAMIN D , *OLDER people , *CATALASE - Abstract
Objective Emerging evidence indicates that vitamin D has anti-oxidative properties. The present study investigates whether serum 25‑hydroxyvitamin D [25(OH)D] is associated with biomarkers of anti-oxidative status in community-dwelling older adults using cross-sectional and longitudinal data. Methods A total of 302 subjects aged 62 to 92 years from Germany (50.6°N) were analysed via cross-sectional approach. For longitudinal analysis, data of 153 subjects were available. Fasting blood samples from 2004 and 2012 were analysed for 25(OH)D concentrations, total anti-oxidative status (TAOS) as well as anti-oxidative enzymes, such as catalase (CAT), glutathione peroxidase (GPx) and superoxide dismutase (SOD). Multiple regression analyses were performed to examine the associations between 25(OH)D and parameters of anti-oxidative status. Results In cross-sectional analyses, 25(OH)D was a significant predictor of CAT ( β = −0.166; P = 0.010), lg 10 GPx ( β = 0.136; P = 0.037) and TAOS ( β = 0.121; P = 0.048) after adjusting for age, sex, percentage total body fat (TBF), month of blood sampling, smoking behaviour and use of vitamin D supplements. Longitudinal change in 25(OH)D concentration positively predicted change in TAOS ( β = 0.224; P = 0.006) after adjusting for sex, baseline TAOS, age, smoking behaviour, use of vitamin D supplements and change in TBF, physical activity level, current time spent outdoors and dietary vitamin D intake. Conclusion The maintenance of an adequate vitamin D status may have a beneficial impact on the anti-oxidative defence system in older adults on a long-term perspective. [ABSTRACT FROM AUTHOR]
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- 2018
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20. Serum 25-hydroxyvitamin D3, parathyroid hormone and blood pressure in an elderly cohort from Germany : a cross-sectional study
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Jungert, Alexandra, Roth, Heinz, Neuhauser-Berthold, Monika, and Justus Liebig University Giessen
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ddc:610 ,intact parathyroid hormone (iPTH) ,blood pressure ,non-obese elderly people ,vitamin D status - Abstract
Background: Although several studies indicate a link between vitamin D status and blood pressure (BP), the results are inconsistent. The purpose of this study is to investigate whether in predominantly non-obese elderly people without vitamin D deficiency or very high intact parathyroid hormone (iPTH) levels serum 25-hydroxyvitamin D3 [25(OH)D3] and iPTH are independently associated with BP.Methods: Cross-sectional data of 132 non-institutionalised subjects (90 women and 42 men, aged 66- 96 years) from Giessen, Germany, were analysed. Serum 25(OH)D3 and iPTH were measured by an electrochemiluminescence immunoassay and BP was determined with a sphygmomanometer. We performed univariate and multiple regression analyses to examine the influence of 25(OH)D3 and iPTH on BP with adjustments for age, body composition and lifestyle factors.Results: While iPTH had no impact on BP, 25(OH)D3 was negatively associated with systolic BP in men, but not in women. After splitting the cohort into antihypertensive medication users and non-users, 25(OH)D3 was a significant predictor for systolic and diastolic BP only in men not receiving antihypertensive medicine, even after multiple adjustment. Adjustment for 25(OH)D3 resulted in an inverse association of iPTH with diastolic BP also only in men without intake of antihypertensive medicine.Conclusions: In elderly men without vitamin D deficiency and not taking antihypertensive medicine, 25(OH)D3 may be a negative determinant of BP, independent of iPTH, body composition and lifestyle factors. Furthermore, iPTH may be an independent negative determinant of diastolic BP in men not taking antihypertensive medicine.
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- 2012
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21. Serum 25-hydroxyvitamin D3 and body composition in an elderly cohort from Germany : a cross-sectional study
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Jungert, Alexandra, Roth, Heinz, Neuhauser-Berthold, Monika, and Justus Liebig University Giessen
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obesity ,ddc:610 ,25-hydroxyvitamin D3 ,total body fat (TBF) ,elderly women - Abstract
BACKGROUND: Emerging evidence indicates that there is an association between vitamin D and obesity. The aim of this study was to investigate whether the level of serum 25-hydroxyvitamin D3 [25(OH)D3] in the elderly is influenced by parameters of anthropometry and body composition independent of potential confounding lifestyle factors and the level of serum intact parathyroid hormone (iPTH). METHODS: Cross-sectional data of 131 independently living participants (90 women, 41 men; aged 66-96years) of the longitudinal study on nutrition and health status in senior citizens of Giessen, Germany were analysed. Concentrations of 25(OH)D3 and iPTH were ascertained by an electrochemiluminescence immunoassay. Body composition was measured by a bioelectrical impedance analysis. We performed univariate and multiple regression analyses to examine the influence of body composition on 25(OH)D3 with adjustments for age, iPTH and lifestyle factors. RESULTS: In univariate regression analyses, 25(OH)D3 was associated with body mass index (BMI), hip circumference and total body fat (TBF) in women, but not in men. Using multiple regression analyses, TBF was shown to be a negative predictor of 25(OH)D3 levels in women even after controlling for age, lifestyle and iPTH (SZ=0.247; P=0.016), whereas the associations between BMI, hip circumference and 25(OH)D3 lost statistical significance after adjusting for iPTH. In men, 25(OH)D3 was not affected by anthropometric or body composition variables. CONCLUSIONS: The results indicate that 25(OH)D3 levels are affected by TBF, especially in elderly women, independent of lifestyle factors and iPTH.
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- 2012
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22. Associations of serum 25-hydroxycholecalciferol and parathyroid hormone with serum lipids differ by sex and vitamin D status.
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Jungert, Alexandra, Roth, Heinz J, and Neuhäuser-Berthold, Monika
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BLOOD serum analysis , *HYDROXYCHOLECALCIFEROLS , *PARATHYROID hormone , *BLOOD lipids , *VITAMIN D in the body , *CROSS-sectional method - Abstract
ObjectiveAlthough emerging evidence indicates an association between vitamin D and serum lipids, the data are still inconsistent. The purpose of the present study was to investigate whether 25-hydroxycholecalciferol (25-hydroxyvitamin D3; 25(OH)D3) or intact parathyroid hormone (iPTH) was independently related to serum lipids in elderly women and men.DesignCross-sectional study. Fasting serum levels of 25(OH)D3, iPTH, TAG, total cholesterol (TC), HDL cholesterol (HDL-C) and LDL cholesterol (LDL-C) were assessed. Body composition was measured by bioelectrical impedance analysis. Lifestyle factors, such as nutrient intake, time spent outdoors, physical activity, smoking, supplement intake and medication, were assessed by questionnaires. Multiple regression analyses were performed to examine associations of 25(OH)D3 and iPTH with serum lipids.SettingGiessen, Germany.SubjectsOne hundred and ninety-three well-functioning German elderly aged 66–96 years.ResultsAfter adjusting for age, body fat, physical activity, smoking, alcohol intake, lipid-modifying drugs and either iPTH or 25(OH)D3, 25(OH)D3 was a predictor of TAG (standardised coefficient beta (β)=–0·180), HDL-C (β=0·197), LDL-C:HDL-C (β=−0·298) and TC:HDL-C (β=−0·302) in women, whereas iPTH was a predictor of HDL-C (β=−0·297) in men. In sub-analysis, associations between 25(OH)D3 and TC (β=−0·252), HDL-C (β=0·230), LDL-C (β=−0·324), LDL-C:HDL-C (β=−0·412) and TC:HDL-C (β=−0·380) were found in women with 25(OH)D3 concentrations above or equal the median vitamin D status (62·3 nmol/l), but not in women with lower 25(OH)D3 concentrations.ConclusionsIn the elderly, associations of 25(OH)D3 and iPTH with serum lipids may differ by sex and may require a vitamin D status above 62 nmol/l. [ABSTRACT FROM AUTHOR]
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- 2015
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23. Sex-specific determinants of serum 25-hydroxyvitamin D3 concentrations in an elderly German cohort: a cross-sectional study.
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Jungert, Alexandra and Neuhäuser-Berthold, Monika
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GERIATRIC nutrition , *BASAL metabolism , *BODY composition , *CHI-squared test , *CREATININE , *DIETARY supplements , *FISHER exact test , *FORECASTING , *GLOMERULAR filtration rate , *BIOELECTRIC impedance , *INCOME , *LONGITUDINAL method , *NUTRITIONAL assessment , *PARATHYROID hormone , *PROBABILITY theory , *QUESTIONNAIRES , *REGRESSION analysis , *SEASONS , *SELF-evaluation , *SEX distribution , *SMOKING , *STATISTICAL hypothesis testing , *SUNSHINE , *VITAMIN D , *ENVIRONMENTAL exposure , *MULTIPLE regression analysis , *SOCIOECONOMIC factors , *BODY mass index , *LIFESTYLES , *INDEPENDENT living , *CROSS-sectional method , *FOOD diaries , *PHYSICAL activity , *DATA analysis software , *DESCRIPTIVE statistics , *NUTRITIONAL status , *MANN Whitney U Test , *OLD age - Abstract
Background: Considering the suggested link between vitamin D insufficiency and several chronic diseases, attention should be given to approaches for improving vitamin D status. Elderly subjects are regarded as a high-risk group for developing an insufficient vitamin D status. Socioeconomic, dietary, lifestyle and environmental factors are considered as influencing factors, whereupon sex differences in predictors of vitamin D status are rarely investigated. The purpose of this study is to identify the main predictors of serum 25-hydroxyvitamin D3 [25(OH)D3] concentrations in elderly subjects by taking into account potential sex differences. Methods: This is a cross-sectional study in 162 independently living German elderly aged 66 to 96 years. Serum 25(OH)D3 concentrations were assessed by an electrochemiluminescence immunoassay. Multiple regression analyses were performed to identify predictors of 25(OH)D3 concentrations stratified by sex. Results: Median 25(OH)D3 concentration was 64 nmol/L and none of the subjects had 25(OH)D3 concentrations < 25 nmol/L. In women, intact parathyroid hormone (iPTH) (β = -0.323), % total body fat (β = -0.208), time spent outdoors (β = 0.328), month of blood sampling (β = 0.229) and intake of vitamin D supplements (β = 0.172) were the predominant predictors of 25(OH)D3, whereas in men, iPTH (β = -0.254), smoking (β = -0.282), physical activity (β = 0.336) and monthly household net income (β = 0.302) predicted 25 (OH)D3 concentrations. The final regression models accounted for 30% and 32% of the variance in 25(OH)D3 concentrations in women and men, respectively. Conclusion: The findings indicate that 25(OH)D3 concentrations are influenced by body composition, month of blood sampling, economic factors, lifestyle, supplement intake and iPTH, but may not be associated with age, sex, dietary factors, kidney function and presence of selected chronic diseases in community-dwelling elderly. Furthermore, our results provide evidence for sex-specific determinants of the vitamin D status, which ought to be considered for preventive strategies. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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24. The lower vitamin C plasma concentrations in elderly men compared with elderly women can partly be attributed to a volumetric dilution effect due to differences in fat-free mass.
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Jungert, Alexandra and Neuhäuser-Berthold, Monika
- Subjects
ANTIOXIDANT analysis ,CHI-squared test ,COMPARATIVE studies ,PROBABILITY theory ,SEX distribution ,STATISTICS ,VITAMIN C ,DATA analysis ,MULTIPLE regression analysis ,BODY mass index ,LIFESTYLES ,CROSS-sectional method ,FOOD diaries ,LEAN body mass ,DATA analysis software ,WAIST circumference ,MANN Whitney U Test ,KRUSKAL-Wallis Test - Abstract
Women show higher vitamin C plasma concentrations than men, but the reasons for this observation still require elucidation. The objective of the present study was to investigate whether sex differences in vitamin C plasma concentrations are present in elderly subjects and whether these differences are due to sex-specific lifestyles, total antioxidant status (TAOS) and/or body composition. Fasting plasma concentrations of vitamin C were assessed by photometric detection in a cross-sectional study of 181 women and eighty-nine men aged 62–92 years. Body composition was determined by bioelectrical impedance analysis. Vitamin C intake was assessed with a 3 d estimated dietary record. Stepwise multiple regression analyses were performed to investigate whether sex is an independent predictor of vitamin C plasma concentrations by controlling for age, vitamin C intake, lifestyle factors, TAOS and body composition. Women showed higher vitamin C plasma concentrations than men (76 v. 62 μmol/l, P< 0·0001). In the multiple regression analysis, male sex was a negative predictor of vitamin C plasma concentrations (β = − 0·214), as long as absolute fat-free mass (FFM) was not considered as a confounder. When absolute FFM was included, sex was no longer a predictor of vitamin C plasma concentrations, whereas absolute FFM (β = − 0·216), physical activity level (β = 0·165), intake of vitamin C supplements (β = 0·164), age (β = 0·147) and smoking (β = − 0·125) affected vitamin C plasma concentrations. The results indicate that a higher absolute FFM, and thus a higher distribution volume of vitamin C, contributes to lower vitamin C plasma concentrations in men than women. [ABSTRACT FROM PUBLISHER]
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- 2015
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25. Dietary vitamin D intake is not associated with 25-hydroxyvitamin D3 or parathyroid hormone in elderly subjects, whereas the calcium-to-phosphate ratio affects parathyroid hormone.
- Author
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Jungert, Alexandra and Neuhäuser-Berthold, Monika
- Subjects
- *
CALCIUM , *DIET , *PARATHYROID hormone , *PHOSPHATES , *VITAMIN D , *INDEPENDENT living , *DESCRIPTIVE statistics , *OLD age - Abstract
Abstract: This cross-sectional study investigates whether serum 25-hydroxyvitamin D3 [25(OH)D3] and intact parathyroid hormone (iPTH) are affected by vitamin D, calcium, or phosphate intake in 140 independently living elderly subjects from Germany (99 women and 41 men; age, 66-96 years). We hypothesized that habitual dietary intakes of vitamin D, calcium, and phosphate are not associated with 25(OH)D3 or iPTH and that body mass index confounds these associations. Serum 25(OH)D3 and iPTH were measured by an electrochemiluminescence immunoassay. Dietary intake was determined using a 3-day estimated dietary record. The median dietary intake levels of vitamin D, calcium, and phosphate were 3 μg/d, 999 mg/d, and 1250 mg/d, respectively. Multiple regression analyses confirmed that dietary vitamin D and calcium did not affect 25(OH)D3 or iPTH; however, supplemental intakes of vitamin D and calcium were associated with 25(OH)D3 after adjustment for age, sex, body composition, sun exposure, physical activity, and smoking. In addition, phosphate intake and the calcium-to-phosphate ratio were associated with iPTH after multiple adjustments. In a subgroup analysis, calcium and vitamin D supplements, as well as phosphate intake, were associated with 25(OH)D3 and/or iPTH in normal-weight subjects only. Our results indicate that habitual dietary vitamin D and calcium intakes have no independent effects on 25(OH)D3 or iPTH in elderly subjects without vitamin D deficiency, whereas phosphate intake and the calcium-to-phosphate ratio affect iPTH. However, vitamin D and calcium supplements may increase 25(OH)D3 and decrease iPTH, even during the summer, but the impact of supplements may depend on body mass index. [Copyright &y& Elsevier]
- Published
- 2013
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26. Serum 25-hydroxyvitamin D3 and body composition in an elderly cohort from Germany: a cross-sectional study.
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Alexandra Jungert, Alexandra Jungert, Heinz J Roth, Heinz J Roth, and Monika Neuhäuser-Berthold, Monika Neuhäuser-Berthold
- Subjects
- *
ANTHROPOMETRY , *BODY composition , *FISHER exact test , *HEALTH behavior , *IMMUNOASSAY , *BIOELECTRIC impedance , *OBESITY , *PARATHYROID hormone , *U-statistics , *VITAMIN D , *VITAMIN D deficiency , *MULTIPLE regression analysis , *BODY mass index , *LIFESTYLES , *CROSS-sectional method , *DATA analysis software , *DESCRIPTIVE statistics , *OLD age - Abstract
Background: Emerging evidence indicates that there is an association between vitamin D and obesity. The aim of this study was to investigate whether the level of serum 25-hydroxyvitamin D3 [25(OH)D3] in the elderly is influenced by parameters of anthropometry and body composition independent of potential confounding lifestyle factors and the level of serum intact parathyroid hormone (iPTH). Methods: Cross-sectional data of 131 independently living participants (90 women, 41 men; aged 66-96 years) of the longitudinal study on nutrition and health status in senior citizens of Giessen, Germany were analysed. Concentrations of 25(OH)D3 and iPTH were ascertained by an electrochemiluminescence immunoassay. Body composition was measured by a bioelectrical impedance analysis. We performed univariate and multiple regression analyses to examine the influence of body composition on 25(OH)D3 with adjustments for age, iPTH and lifestyle factors. Results: In univariate regression analyses, 25(OH)D3 was associated with body mass index (BMI), hip circumference and total body fat (TBF) in women, but not in men. Using multiple regression analyses, TBF was shown to be a negative predictor of 25(OH)D3 levels in women even after controlling for age, lifestyle and iPTH (β = -0.247; P = 0.016), whereas the associations between BMI, hip circumference and 25(OH)D3 lost statistical significance after adjusting for iPTH. In men, 25(OH)D3 was not affected by anthropometric or body composition variables. Conclusions: The results indicate that 25(OH)D3 levels are affected by TBF, especially in elderly women, independent of lifestyle factors and iPTH. [ABSTRACT FROM AUTHOR]
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- 2012
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27. Intra-Individual Variation and Reliability of Biomarkers of the Antioxidant Defense System by Considering Dietary and Lifestyle Factors in Premenopausal Women.
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Jungert, Alexandra, Frank, Jan, and Galvano, Fabio
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ANTIOXIDANTS ,UBIQUINONES ,GLUTATHIONE ,BIOLOGICAL tags ,BIOMARKERS ,OXIDANT status ,REFERENCE values ,GLUTATHIONE peroxidase - Abstract
Epidemiological studies frequently rely on a single biomarker measurement to assess the relationship between antioxidant status and diseases. This bears an inherent risk for misclassification, if the respective biomarker has a high intra-individual variability. The present study investigates the intra-individual variation and reliability of enzymatic and non-enzymatic biomarkers of the antioxidant system in premenopausal women. Forty-four apparently healthy females provided three consecutive fasting blood samples in a four-week rhythm. Analyzed blood biomarkers included Trolox equivalent antioxidant capacity (TEAC), catalase, glutathione peroxidase, glutathione, vitamin C, bilirubin, uric acid, coenzyme Q10, tocopherols, carotenoids and retinol. Intra- and inter-individual variances for each biomarker were estimated before and after adjusting for relevant influencing factors, such as diet, lifestyle and use of contraceptives. Intraclass correlation coefficient (ICC), index of individuality, reference change value and number of measurements needed to confine attenuation in regression coefficients were calculated. Except for glutathione and TEAC, all biomarkers showed a crude ICC ≥ 0.50 and a high degree of individuality indicating that the reference change value is more appropriate than population-based reference values to scrutinize and classify intra-individual changes. Apart from glutathione and TEAC, between 1 and 9 measurements were necessary to reduce attenuation in regression coefficients to 10%. The results indicate that the majority of the assessed biomarkers have a fair to very good reliability in healthy premenopausal women, except for glutathione and TEAC. To assess the status of the antioxidant system, the use of multiple measurements and biomarkers is recommended. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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28. Trajectories of Body Composition during Advanced Aging in Consideration of Diet and Physical Activity: A 20-Year Longitudinal Study.
- Author
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Jungert, Alexandra, Eichner, Gerrit, and Neuhäuser-Berthold, Monika
- Abstract
This prospective study investigates age-dependent changes in anthropometric data and body composition over a period of two decades in consideration of physical activity and diet in community-dwelling subjects ≥60 years. Overall, 401 subjects with median follow-up time of 12 years were examined. Fat-free mass (FFM) and fat mass (FM) were analyzed using bioelectrical impedance analysis. Physical activity was assessed via a self-administered questionnaire. Dietary intake was examined by 3-day dietary records. Linear mixed-effects models were used to analyze the influence of age, sex, physical activity and energy/protein intake on anthropometric data and body composition by considering year of entry, use of diuretics and diagnosis of selected diseases. At baseline, median values for daily energy and protein intakes were 8.5 megajoule and 81 g and physical activity index was 1.7. After adjusting for covariates, advancing age was associated with parabolic changes indicating overall changes from age 60 to 90 years in women and men in body mass: −4.7 kg, −5.0 kg; body mass index: +0.04 kg/m
2 , −0.33 kg/m2 ; absolute FFM: −2.8 kg, −3.5 kg; absolute FM: −1.8 kg, −1.2 kg and waist circumference: +16 cm, +12 cm, respectively. No age-dependent changes were found for upper arm circumference and relative (%) FFM. Dietary and lifestyle factors were not associated with changes in anthropometric or body composition parameters. In summary, the results indicate non-linear age-dependent changes in anthropometric data and body composition, which are largely unaffected by the degree of habitual physical activity and dietary protein intake in well-nourished community-dwelling subjects. [ABSTRACT FROM AUTHOR]- Published
- 2020
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29. Longitudinal age-related changes in cobalamin and folate status in community-dwelling older adults.
- Author
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Jungert, Alexandra, Zenke-Philippi, Carola, and Neuhäuser-Berthold, Monika
- Abstract
Advancing age is regarded as a risk factor for an insufficient cobalamin and folate status. However, longitudinal data are lacking and little is known on the impact of age in subjects ≥ 60 years after considering potential confounding factors. Therefore, the present study investigates age-related changes in cobalamin and folate status in older adults by using longitudinal data of 332 German subjects aged ≥ 60 years, who participated in the longitudinal study on nutrition and health status of senior citizens in Giessen (GISELA study). All subjects had complete data records on at least three follow-ups between 1997 and 2014. The mean follow-up time was 12 years. Fasting serum concentrations of cobalamin and folate were determined with SimulTRAC-SNB radio assay kit. In each follow-up, body composition (bioelectrical impedance analysis), dietary cobalamin and folate intakes (3-day estimated dietary record), supplement use and lifestyle factors (questionnaires) were assessed. Linear mixed models were used to analyze age-related changes in serum concentrations of cobalamin and folate by considering sex, absolute fat-free mass, supplement use, dietary intakes and smoking behavior as potential confounding variables. Furthermore, due to the metabolic interaction of cobalamin and folate, linear mixed models implemented a mutual adjustment of serum cobalamin and serum folate. At baseline, 11.4 % and 7.8 % of the subjects had cobalamin concentrations < 148 pmol/L and folate concentrations < 10 nmol/L, respectively. In contrast, dietary cobalamin intakes < 4 μg/d and folate intakes < 300 μg/d were found in 24.4 % and 76.5 % of the subjects, respectively. Without adjustments, a positive influence of age on serum cobalamin [parameter estimate (95 % CI) = 4.57 (1.67, 7.46)] and serum folate [0.29 (0.18, 0.40)] was found. After multiple adjustments, age was still a positive predictor of serum folate [0.25 (0.14, 0.36)], whereas no significant influence on serum cobalamin was found [2.73 (-0.23, 5.69)]. Similar results were noticed when the analyses were restricted to non-users of B-vitamin/multi-vitamin supplements. In conclusion, the present study in community-dwelling subjects does not confirm age-related declines in serum concentrations of cobalamin and folate between the ages of 60 and 90 years. Although a significant proportion of the subjects showed dietary intake levels below the current European references values, serum concentrations of cobalamin and folate were predominantly in reference ranges. Longitudinal investigations on other biomarkers of cobalamin and folate status are warranted. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
30. Serum 25-hydroxyvitamin D3 and body composition in an elderly cohort from Germany: a cross-sectional study
- Author
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Jungert Alexandra, Roth Heinz J, Neuhäuser-Berthold Monika, and Institute of Nutritional Science
- Subjects
25-Hydroxyvitamin D3 ,obesity ,Nutrition and Dietetics ,Fat mass ,Research ,25-hydroxyvitamin D3 ,Endocrinology, Diabetes and Metabolism ,Medicine (miscellaneous) ,lcsh:TX341-641 ,Body composition ,Medical sciences Medicine ,lcsh:Nutritional diseases. Deficiency diseases ,Elderly ,total body fat (TBF) ,ddc:610 ,elderly women ,lcsh:Nutrition. Foods and food supply ,lcsh:RC620-627 - Abstract
Background Emerging evidence indicates that there is an association between vitamin D and obesity. The aim of this study was to investigate whether the level of serum 25-hydroxyvitamin D3 [25(OH)D3] in the elderly is influenced by parameters of anthropometry and body composition independent of potential confounding lifestyle factors and the level of serum intact parathyroid hormone (iPTH). Methods Cross-sectional data of 131 independently living participants (90 women, 41 men; aged 66–96 years) of the longitudinal study on nutrition and health status in senior citizens of Giessen, Germany were analysed. Concentrations of 25(OH)D3 and iPTH were ascertained by an electrochemiluminescence immunoassay. Body composition was measured by a bioelectrical impedance analysis. We performed univariate and multiple regression analyses to examine the influence of body composition on 25(OH)D3 with adjustments for age, iPTH and lifestyle factors. Results In univariate regression analyses, 25(OH)D3 was associated with body mass index (BMI), hip circumference and total body fat (TBF) in women, but not in men. Using multiple regression analyses, TBF was shown to be a negative predictor of 25(OH)D3 levels in women even after controlling for age, lifestyle and iPTH (ß = −0.247; P = 0.016), whereas the associations between BMI, hip circumference and 25(OH)D3 lost statistical significance after adjusting for iPTH. In men, 25(OH)D3 was not affected by anthropometric or body composition variables. Conclusions The results indicate that 25(OH)D3 levels are affected by TBF, especially in elderly women, independent of lifestyle factors and iPTH.
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31. The Suitability of Questionnaires for Exploring Relations of Dietary Behavior and Tooth Wear.
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Schlenz MA, Schlenz MB, Wöstmann B, Jungert A, Glatt AS, and Ganss C
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- Acids, Diet, Humans, Longitudinal Studies, Surveys and Questionnaires, Tooth Wear etiology
- Abstract
Tooth wear is a relevant oral health problem, especially at a young age. Although ongoing acid exposures may contribute to tooth wear, the role of acidic dietary components in this context remains unclear. To date, in tooth wear studies, dietary behavior has been assessed using traditional questionnaires, but the suitability of this approach has not been investigated so far. In our longitudinal study, we followed 91 participants (21.0 ± 2.2 years) over a period of 1 year (373 ± 19 days) and monitored tooth wear with an intraoral scanner. At baseline (T0) and at the end (T1), we assessed dietary behavior with questionnaires asking about the consumption frequencies of acidic dietary components and the acid taste preferences. Complete data were available from 80 subjects. The consumption frequencies of T0 and T1 correlated weakly to moderately. Taste preferences seem to be a more consistent measure, but there was predominantly no significant correlation with the corresponding consumption frequencies. None of the dietary parameters showed a significant relation with tooth wear. The suitability of dietary questionnaires to assess tooth-relevant dietary behavior seems to be limited.
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- 2022
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32. Interrelation between Plasma Concentrations of Vitamins C and E along the Trajectory of Ageing in Consideration of Lifestyle and Body Composition: A Longitudinal Study over Two Decades.
- Author
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Jungert A and Neuhäuser-Berthold M
- Subjects
- Aged, Aged, 80 and over, Antioxidants, Biomarkers blood, Cholesterol blood, Diet, Dietary Supplements, Female, Germany, Humans, Lipids blood, Longitudinal Studies, Male, Middle Aged, alpha-Tocopherol blood, Aging physiology, Ascorbic Acid blood, Body Composition, Life Style, Plasma chemistry, Vitamin E blood
- Abstract
Although the interrelation between vitamins C and E has been demonstrated on an experimental level, its impact on biomarkers in community-dwelling subjects along the trajectory of ageing has not yet been shown. The present longitudinal study investigates the determinants and interrelation of vitamins C and E plasma concentrations in 399 subjects aged ≥60 years with a median follow-up time of 12 years. Linear mixed-effects models were used to analyze the influence of age, sex, body composition, dietary intake, physical activity, smoking and supplement/drug use on plasma vitamin C, plasma α-tocopherol and α-tocopherol/total cholesterol ratio. At baseline, median plasma concentrations of vitamin C and α-tocopherol were 74 and 35 µmol/L. Absolute fat-free mass, physical activity, use of supplements, and plasma α-tocopherol were main determinants of plasma vitamin C in the course of ageing. For the α-tocopherol/total cholesterol ratio, age, use of supplements, use of lipid-modifying drugs, and plasma vitamin C were main determinants. The results reveal a stable positive interrelation between plasma concentrations of vitamins C and E along the trajectory of ageing independent of the other identified determinants. The possible regulatory mechanisms that could explain this robust positive interrelation remain to be elucidated.
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- 2020
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33. Vitamin Substitution Beyond Childhood—Requirements and Risks
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Jungert A, Quack Lötscher K, and Rohrmann S
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- Adult, Germany, Humans, Risk Assessment, Dietary Supplements statistics & numerical data, Vitamins administration & dosage
- Abstract
Background: Vitamins are vitally important, but they are not always adequately supplied with the diet. In this review, we present the advantages and disadvantages of vitamin supplementation and the indications for it in various life situations., Methods: This review is based on pertinent publications retrieved by a selective search of the literature., Results: The German National Nutrition Survey II (Nationale Verzehrsstudie II) showed that most people in Germany consume adequate amounts of vitamins in their diet, with the exception of vitamin D and folate. Supplements are often taken by adults who already consume a balanced diet. Depending on the vitamin, 3-13% of survey respondents took vitamin supplements; the ones most often taken were vitamins C and E. No convincing evidence has yet demonstrated a health benefit from vitamin supplementation in addition to a balanced diet for the primary prevention of nutrition-associated diseases. Vitamin supplementation is indicated in certain specific life situations, e.g., pregnancy, but otherwise unnecessary, unless a deficiency has been diagnosed or the individual is at elevated risk., Conclusion: Vitamin supplementation is recommended for certain population groups: folic acid for pregnant women, vitamin B12 for vegans and persons with resorption disorders, vitamin D for persons with insufficient endogenous synthesis. In all other cases, it should first be tested whether the individual might be substantially helped by dietary changes alone. In general, the potential adverse effects of vitamin supplementation need to be considered, and its benefits weighed against its risks.
- Published
- 2020
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34. Sex-specific determinants of serum 25-hydroxyvitamin D3 concentrations in an elderly German cohort: a cross-sectional study.
- Author
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Jungert A and Neuhäuser-Berthold M
- Abstract
Background: Considering the suggested link between vitamin D insufficiency and several chronic diseases, attention should be given to approaches for improving vitamin D status. Elderly subjects are regarded as a high-risk group for developing an insufficient vitamin D status. Socioeconomic, dietary, lifestyle and environmental factors are considered as influencing factors, whereupon sex differences in predictors of vitamin D status are rarely investigated. The purpose of this study is to identify the main predictors of serum 25-hydroxyvitamin D3 [25(OH)D3] concentrations in elderly subjects by taking into account potential sex differences., Methods: This is a cross-sectional study in 162 independently living German elderly aged 66 to 96 years. Serum 25(OH)D3 concentrations were assessed by an electrochemiluminescence immunoassay. Multiple regression analyses were performed to identify predictors of 25(OH)D3 concentrations stratified by sex., Results: Median 25(OH)D3 concentration was 64 nmol/L and none of the subjects had 25(OH)D3 concentrations < 25 nmol/L. In women, intact parathyroid hormone (iPTH) (β = -0.323), % total body fat (β = -0.208), time spent outdoors (β = 0.328), month of blood sampling (β = 0.229) and intake of vitamin D supplements (β = 0.172) were the predominant predictors of 25(OH)D3, whereas in men, iPTH (β = -0.254), smoking (β = -0.282), physical activity (β = 0.336) and monthly household net income (β = 0.302) predicted 25(OH)D3 concentrations. The final regression models accounted for 30% and 32% of the variance in 25(OH)D3 concentrations in women and men, respectively., Conclusion: The findings indicate that 25(OH)D3 concentrations are influenced by body composition, month of blood sampling, economic factors, lifestyle, supplement intake and iPTH, but may not be associated with age, sex, dietary factors, kidney function and presence of selected chronic diseases in community-dwelling elderly. Furthermore, our results provide evidence for sex-specific determinants of the vitamin D status, which ought to be considered for preventive strategies.
- Published
- 2015
- Full Text
- View/download PDF
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