10 results on '"Jonathan Lane"'
Search Results
2. Connecting supplier and DoD blockchains for transparent part tracking
- Author
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Francis Asuncion, Adam Brinckman, Dwayne Cole, Jeffrey Curtis, Matt Davis, Timothy Dunlevy, Calvin Farmer, Andrew Harrison, Daniel P. Johnson, Joshua Joyce, Chris Klubertanz, Jonathan Lane, John Martin, Jarek Nabrzyski, Joel Neidig, Deysi Olivares, Gregory Robinson, Gabriel Rodriguez, Chris Root, Karen Rowand, Al Salour, Jeff Score, David Scott, Ian Taylor, Chandler Thompson, Huy Truong, Xiqun Wang, and Dale Warren
- Subjects
Blockchain ,Smart contracts ,Supply chain ,Department of defense (DoD) ,GraphQL ,Enterprise blockchain systems ,Information technology ,T58.5-58.64 - Abstract
Blockchains have been around for more than ten years, and since 2015, a plethora of systems have been launched to target more flexible use cases. More recently, several enterprise blockchain systems, such as Consensys Quorum and Hyperledger Fabric, have been launched to make blockchain simpler to apply in complex organizational configurations. In this paper, we identify a specific Department of Defense use case, extrapolate requirements, and perform a thorough assessment of the different layers of the blockchain stack to identify the existing state of the art and undertake a gap analysis of the technology for this context. We describe a platform that meets many of these challenges and show how we architected, designed, and implemented a solution for this use case for deployment at NAVAIR. This solution connects transactions from two separate blockchain systems, Consensys Quorum and Hyperledger Fabric, by using a graph-based approach that preserves privacy while enabling full transparency across the military and supplier networks.
- Published
- 2021
- Full Text
- View/download PDF
3. Exposure of Bifidobacterium longum subsp. infantis to Milk Oligosaccharides Increases Adhesion to Epithelial Cells and Induces a Substantial Transcriptional Response.
- Author
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Devon W Kavanaugh, John O'Callaghan, Ludovica F Buttó, Helen Slattery, Jonathan Lane, Marguerite Clyne, Marian Kane, Lokesh Joshi, and Rita M Hickey
- Subjects
Medicine ,Science - Abstract
In this study, we tested the hypothesis that milk oligosaccharides may contribute not only to selective growth of bifidobacteria, but also to their specific adhesive ability. Human milk oligosaccharides (3'sialyllactose and 6'sialyllactose) and a commercial prebiotic (Beneo Orafti P95; oligofructose) were assayed for their ability to promote adhesion of Bifidobacterium longum subsp. infantis ATCC 15697 to HT-29 and Caco-2 human intestinal cells. Treatment with the commercial prebiotic or 3'sialyllactose did not enhance adhesion. However, treatment with 6'sialyllactose resulted in increased adhesion (4.7 fold), while treatment with a mixture of 3'- and 6'-sialyllactose substantially increased adhesion (9.8 fold) to HT-29 intestinal cells. Microarray analyses were subsequently employed to investigate the transcriptional response of B. longum subsp. infantis to the different oligosaccharide treatments. This data correlated strongly with the observed changes in adhesion to HT-29 cells. The combination of 3'- and 6'-sialyllactose resulted in the greatest response at the genetic level (both in diversity and magnitude) followed by 6'sialyllactose, and 3'sialyllactose alone. The microarray data was further validated by means of real-time PCR. The current findings suggest that the increased adherence phenotype of Bifidobacterium longum subsp. infantis resulting from exposure to milk oligosaccharides is multi-faceted, involving transcription factors, chaperone proteins, adhesion-related proteins, and a glycoside hydrolase. This study gives additional insight into the role of milk oligosaccharides within the human intestine and the molecular mechanisms underpinning host-microbe interactions.
- Published
- 2013
- Full Text
- View/download PDF
4. Perspective: Leveraging the Gut Microbiota to Predict Personalized Responses to Dietary, Prebiotic, and Probiotic Interventions
- Author
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Sean M Gibbons, Thomas Gurry, Johanna W Lampe, Anirikh Chakrabarti, Veerle Dam, Amandine Everard, Almudena Goas, Gabriele Gross, Michiel Kleerebezem, Jonathan Lane, Johanna Maukonen, Ana Lucia Barretto Penna, Bruno Pot, Ana M Valdes, Gemma Walton, Adrienne Weiss, Yoghatama Cindya Zanzer, Naomi V Venlet, Michela Miani, Department of Bio-engineering Sciences, Industrial Microbiology, and UCL - SSS/LDRI - Louvain Drug Research Institute
- Subjects
Nutrition and Dietetics ,Probiotics ,Medicine (miscellaneous) ,microbiome ,artificial intelligence ,Gastrointestinal Microbiome ,Prebiotics ,probiotics ,Artificial Intelligence ,personalized healthcare ,prebiotic ,WIAS ,microbiota ,Animals ,Humans ,Host-Microbe Interactomics ,precision healthcare ,prebiotics ,diet ,personalized nutrition ,precision nutrition ,probiotic ,Food Science ,VLAG - Abstract
Humans often show variable responses to dietary, prebiotic, and probiotic interventions. Emerging evidence indicates that the gut microbiota is a key determinant for this population heterogeneity. Here, we provide an overview of some of the major computational and experimental tools being applied to critical questions of microbiota-mediated personalized nutrition and health. First, we discuss the latest advances in in silico modeling of the microbiota-nutrition-health axis, including the application of statistical, mechanistic, and hybrid artificial intelligence models. Second, we address high-throughput in vitro techniques for assessing interindividual heterogeneity, from ex vivo batch culturing of stool and continuous culturing in anaerobic bioreactors, to more sophisticated organ-on-a-chip models that integrate both host and microbial compartments. Third, we explore in vivo approaches for better understanding of personalized, microbiota-mediated responses to diet, prebiotics, and probiotics, from nonhuman animal models and human observational studies, to human feeding trials and crossover interventions. We highlight examples of existing, consumer-facing precision nutrition platforms that are currently leveraging the gut microbiota. Furthermore, we discuss how the integration of a broader set of the tools and techniques described in this piece can generate the data necessary to support a greater diversity of precision nutrition strategies. Finally, we present a vision of a precision nutrition and healthcare future, which leverages the gut microbiota to design effective, individual-specific interventions.
- Published
- 2022
5. Connecting supplier and DoD blockchains for transparent part tracking
- Author
-
Gregory Robinson, Chris Root, Francis Asuncion, Al Salour, Jarek Nabrzyski, Jeff Score, Timothy Dunlevy, Dale Warren, Chandler Thompson, Andrew Harrison, Daniel P. Johnson, Calvin Farmer, Chris Klubertanz, Deysi Olivares, David F. Scott, Karen Rowand, John Martin, Ian Taylor, Dwayne Cole, Huy Truong, Gabriel Rodriguez, Xiqun Wang, Adam Brinckman, Jeffrey L. Curtis, Jonathan Lane, Matthew Davis, Joel Neidig, and Joshua Joyce
- Subjects
GraphQL ,Blockchain ,Computer science ,General Engineering ,Context (language use) ,Transparency (human–computer interaction) ,Information technology ,Gap analysis ,Supply chain ,T58.5-58.64 ,Enterprise blockchain systems ,Software deployment ,Systems engineering ,General Earth and Planetary Sciences ,Graph (abstract data type) ,Use case ,State (computer science) ,Smart contracts ,Department of defense (DoD) ,General Environmental Science - Abstract
Blockchains have been around for more than ten years, and since 2015, a plethora of systems have been launched to target more flexible use cases. More recently, several enterprise blockchain systems, such as Consensys Quorum and Hyperledger Fabric, have been launched to make blockchain simpler to apply in complex organizational configurations. In this paper, we identify a specific Department of Defense use case, extrapolate requirements, and perform a thorough assessment of the different layers of the blockchain stack to identify the existing state of the art and undertake a gap analysis of the technology for this context. We describe a platform that meets many of these challenges and show how we architected, designed, and implemented a solution for this use case for deployment at NAVAIR. This solution connects transactions from two separate blockchain systems, Consensys Quorum and Hyperledger Fabric, by using a graph-based approach that preserves privacy while enabling full transparency across the military and supplier networks.
- Published
- 2021
6. CyberKnife® fixed cone and Iris™ defined small radiation fields: Assessment with a high‐resolution solid‐state detector array
- Author
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Ebert A. Martin, Jonathan Lane, Susanna Guatelli, Vladimir Perevertaylo, Marco Petasecca, Tomas Kron, Giordano Biasi, Benjamin Hug, Anatoly B. Rosenfeld, and Garry Grogan
- Subjects
87.55.Qr ,CyberKnife ,87.56.Fc ,SRT ,quality assurance ,Radiosurgery ,Linear particle accelerator ,030218 nuclear medicine & medical imaging ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,Optics ,Cyberknife ,law ,Dosimetry ,Radiation Oncology Physics ,Radiology, Nuclear Medicine and imaging ,Radiometry ,Instrumentation ,Image resolution ,small‐field dosimetry ,Physics ,Radiation ,Dosimeter ,business.industry ,Detector ,87.55.k ,Reproducibility of Results ,Collimator ,87.57.uq ,Multileaf collimator ,030220 oncology & carcinogenesis ,Particle Accelerators ,business ,87.53.Ly ,87.53.Bn ,2D monolithic silicon array detector ,Monte Carlo Method - Abstract
Purpose The challenges of accurate dosimetry for stereotactic radiotherapy (SRT) with small unflattened radiation fields have been widely reported in the literature. In this case, suitable dosimeters would have to offer a submillimeter spatial resolution. The CyberKnife® (Accuray Inc., Sunnyvale, CA, USA) is an SRT‐dedicated linear accelerator (linac), which can deliver treatments with submillimeter positional accuracy using circular fields. Beams are delivered with the desired field size using fixed cones, the InCise™ multileaf collimator or a dynamic variable‐aperture Iris™ collimator. The latter, allowing for field sizes to be varied during treatment delivery, has the potential to decrease treatment time, but its reproducibility in terms of output factors (OFs) and dose profiles (DPs) needs to be verified. Methods A 2D monolithic silicon array detector, the “Octa”, was evaluated for dosimetric quality assurance (QA) for a CyberKnife system. OFs, DPs, percentage depth‐dose (PDD) and tissue maximum ratio (TMR) were investigated, and results were benchmarked against the PTW SRS diode. Cross‐plane, in‐plane and 2 diagonal dose profiles were measured simultaneously with high spatial resolution (0.3 mm). Monte Carlo (MC) simulations with a GEANT4 (GEometry ANd Tracking 4) tool‐kit were added to the study to support the experimental characterization of the detector response. Results For fixed cones and the Iris, for all field sizes investigated in the range between 5 and 60 mm diameter, OFs, PDDs, TMRs, and DPs in terms of FWHM measured by the Octa were accurate within 3% when benchmarked against the SRS diode and MC calculations. Conclusions The Octa was shown to be an accurate dosimeter for measurements with a 6 MV FFF beam delivered with a CyberKnife system. The detector enabled real‐time dosimetric verification for the variable aperture Iris collimator, yielding OFs and DPs consistent with those obtained with alternative methods.
- Published
- 2018
7. Being Santa Claus : What I Learned About the True Meaning of Christmas
- Author
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Sal Lizard, Jonathan Lane, Sal Lizard, and Jonathan Lane
- Subjects
- Santa Claus
- Abstract
A veteran Santa reveals heartwarming true stories and lessons from his twenty-year career spreading Christmas magic.With the holiday shopping season beginning earlier each year, more than ever. Americans are struggling to remember the true meaning of Christmas. And who better to deliver the gift of Christmas inspiration than a man who has spent the last two decades playing Santa?Sal Lizard was in his twenties when his beard and hair turned completely white. Today he appears everywhere from malls and parades to schools and hospitals. And— from his custom-made red velvet suits to the mistletoe that hangs from the rearview mirror in his Santa-mobile—he is Santa Claus three hundred and sixty-five days a year. In Being Santa Claus Sal reflects on his experiences with both children and adults including: Christmas magic is all around us: We don't always see it, but it is there, shaping and enriching our lives. Sometimes you need to go that extra mile:Santa Claus is the one person who can't even use a blizzard as an excuse not to honor his commitments, and Sal teaches adults the importance of always showing up for our children. Even a small child can make a big difference: Sal has met some impressive children over the years, and he's learned that you don't need to be a grown-up to make an impact on the world around you.In Being Santa Claus Sal shares these lessons, along with often heartwarming, occasionally heartbreaking, and sometimes downright hysterical stories from his twenty-year career as Santa.
- Published
- 2012
8. Foundation Website Creation with HTML5, CSS3, and JavaScript
- Author
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Joe Lewis, Jonathan Lane, Meitar Moscovitz, Tom Barker, Joe Lewis, Jonathan Lane, Meitar Moscovitz, and Tom Barker
- Subjects
- HTML (Document markup language), Web site development, Web sites--Design, JavaScript (Computer program language), Cascading style sheets
- Abstract
Foundation Website Creation with HTML5, CSS3, and JavaScript shows the entire process of building a website. This process involves much more than just technical knowledge, and this book provides all the information you'll need to understand the concepts behind designing and developing for the Web, as well as the best means to deliver professional results based on best practices. Of course, there is far more to building a successful website than knowing a little Hypertext Markup Language (HTML). The process starts long before any coding takes place, and this book introduces you to the agile development process, explaining why this method makes so much sense for web projects and how best to implement it. We also make sure you're up to date by using the latest HTML5 features. Planning is vital, so you'll also learn to use techniques such as brainstorming, wireframes, mockups, and prototypes to get your project off to the best possible start and help ensure smooth progress as it develops. An understanding of correct, semantic markup is essential for any web professional; this book explains how HTML5 should be used to structure content so that the markup adheres to current web standards. You'll learn about the wide range of HTML5 elements available to you, and you'll learn how and when to use them through building example web pages. Without creative use of Cascading Style Sheets (CSS), websites would all look largely the same. CSS enables you to set your website apart from the rest, while maintaining the integrity of your markup. We'll showcase the new features of CSS3 and how you can use them. You'll learn how CSS3 works and how to apply styles to your pages, allowing you to realize your design ideas in the browser. JavaScript can be used to make your website easier and more interesting to use. This book provides information on appropriate uses of this technology and introduces the concepts of JavaScriptprogramming. You'll also see how JavaScript works as part of the much-hyped technique Ajax, and in turn, where Ajax fits into the wider Web 2.0 picture. While a website is being built, it needs to be tested across multiple browsers and platforms to ensure that the site works for all users, regardless of ability or disability, and this book explains how best to accomplish these tasks. Then, it discusses the process of launching and maintaining the site so that it will continue to work for all its users throughout its life cycle. Foundation Website Creation with HTML5, CSS3, and JavaScript concludes by covering server-side technologies, acting as a guide to the different options available. With insights from renowned experts such as Jason Fried of 37signals, Daniel Burka of Digg and Pownce, and Chris Messina of Citizen Agency, Foundation Website Creation with CSS, XHTML, and JavaScript provides invaluable information applicable to every web project—regardless of size, scope, or budget.
- Published
- 2012
9. Foundation Website Creation with CSS, XHTML, and JavaScript
- Author
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Steve Smith, Jonathan Lane, Steve Smith, and Jonathan Lane
- Subjects
- Internet programming, Web site development, Web sites--Design, Cascading style sheets, XHTML (Document markup language), JavaScript (Computer program language)
- Abstract
Foundation Website Creation with CSS, XHTML, and JavaScript covers the entire process of building a website. This process involves much more than just technical knowledge, and this book provides you with all the information you'll need to understand the concepts behind designing and developing for the Web, as well as the best means to deliver professional, best-practice-based results. There is far more to building a successful website than knowing a little Hypertext Markup Language (HTML). The process starts long before any coding takes place, and this book introduces you to the agile development process, explaining why this method makes so much sense for web projects and how best to implement it. Planning is vital, so you'll also learn how to use techniques such as brainstorming, wireframes, mockups, and prototypes to get your project off to the best possible start and help ensure smooth progress as it develops. An understanding of correct, semantic markup is essential to any web professional, so this book explains how XHTML should be used to structure content so that the markup adheres to current web standards. You'll learn about the wide range of HTML elements available to you, and you'll learn how and when to use them through building example web pages. Without creative use of Cascading Style Sheets (CSS), websites would all look largely the same. CSS gives you the ability to set your website apart from the rest while maintaining the integrity of your markup. You'll learn how CSS works and how to apply styles to your pages, enabling you to realize your design ideas in the browser. JavaScript can be used to make your website easier and more interesting to use. This book provides information on appropriate uses of this technology and introduces the concepts of programming using it. You'll also see how JavaScript works as part of the much-hyped technique Ajax and in turn where Ajax fits into the wider Web 2.0picture. While a website is being built, it needs to be tested across multiple browsers and platforms to ensure that the site works for all users, regardless of ability or disability, and the book explains how best to do these tasks. Then, it discusses the process of launching and maintaining the site so that it will continue to work for all its users throughout its life-cycle. The book concludes by covering server-side technologies, acting as a guide to the different options available and explaining differences between available products. With insights from renowned experts such as Jason Fried of 37signals, Daniel Burka of Digg and Pownce, and Chris Messina of Citizen Agency, this book provides invaluable information applicable to every web project, regardless of size, scope, or budget.
- Published
- 2008
10. Quantifying motor recovery after stroke using independent vector analysis and graph-theoretical analysis
- Author
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Jonathan Laney, Tülay Adalı, Sandy McCombe Waller, and Kelly P. Westlake
- Subjects
IVA ,fMRI ,Stroke ,Graph-theoretical analysis ,Computer applications to medicine. Medical informatics ,R858-859.7 ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
The assessment of neuroplasticity after stroke through functional magnetic resonance imaging (fMRI) analysis is a developing field where the objective is to better understand the neural process of recovery and to better target rehabilitation interventions. The challenge in this population stems from the large amount of individual spatial variability and the need to summarize entire brain maps by generating simple, yet discriminating features to highlight differences in functional connectivity. Independent vector analysis (IVA) has been shown to provide superior performance in preserving subject variability when compared with widely used methods such as group independent component analysis. Hence, in this paper, graph-theoretical (GT) analysis is applied to IVA-generated components to effectively exploit the individual subjects' connectivity to produce discriminative features. The analysis is performed on fMRI data collected from individuals with chronic stroke both before and after a 6-week arm and hand rehabilitation intervention. Resulting GT features are shown to capture connectivity changes that are not evident through direct comparison of the group t-maps. The GT features revealed increased small worldness across components and greater centrality in key motor networks as a result of the intervention, suggesting improved efficiency in neural communication. Clinically, these results bring forth new possibilities as a means to observe the neural processes underlying improvements in motor function.
- Published
- 2015
- Full Text
- View/download PDF
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