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318 results on '"Jia, Jianjun"'

35. Association of CHAT Gene Polymorphism rs3793790 and rs2177370 with Donepezil Response and the Risk of Alzheimer's Disease Continuum.

Author

Sun, Hongmei, Lv, Chao, Zhang, Xiaoxue, Sun, Xuan, Chen, Siyu, Li, Ke, Hu, Yazhuo, Feng, Yuxin, Yin, Tong, and Jia, Jianjun

Subjects
DISEASE risk factors, GENETIC polymorphisms, SINGLE nucleotide polymorphisms, DONEPEZIL, ALZHEIMER'S disease
Abstract

This study focused on the associations between two single nucleotide polymorphisms (SNPs) (rs3793790 and rs2177370) located in the CHAT gene and donepezil response in ADC patients, and further evaluated the associations between the two SNPs and ADC. Material and Methods: According to 2018 National Institute on Aging and Alzheimer's Association (NIA-AA) standard, amyloid β-protein positive (Aβ+) and negative (Aβ-) patients were recruited according to the Aβ-PET/CT standard. rs3793790 and rs2177370 were genotyped in buccal swab samples by using the MassARRAY system. We used the Mini Mental State Examination (MMSE) in Chinese version, caregiver evaluation, and prescribing behavior to assess therapeutic response during the 9-month period. Using logistic regression models, we analyzed the relationship between the two SNPs and donepezil response in 58 Aβ+ patients treated with donepezil alone at the initial diagnosis of ADC. We also explored a probable link between the two SNPs and ADC in 147 Aβ+ and 73 Aβ– patients using a logistic regression analysis. Results: The chance of donepezil response was higher in patients with the G allele of rs3793790 and/or the A allele of rs2177370 than in those without (odds ratio (OR) 6.83, 95% confidence interval (CI): 1.64– 28.49). Additionally, the rs3793790 variant was not associated with ADC, whereas the A allele in rs2177370 increased 1.51-fold the ADC risk (OR 2.51, 95% CI: 1.28– 4.95). Conclusion: The genetic variants of rs3793790 and rs2177370 were associated with the donepezil response, and rs2177370 may have a moderate relationship with the risk of ADC. [ABSTRACT FROM AUTHOR]

Published
2024
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40. A 36-week multicenter, randomized, double-blind, placebo-controlled, parallel-group, phase 3 clinical trial of sodium oligomannate for mild-to-moderate Alzheimer’s dementia

Author

Xiao, Shifu, Chan, Piu, Wang, Tao, Hong, Zhen, Wang, Shuzhen, Kuang, Weihong, He, Jincai, Pan, Xiaoping, Zhou, Yuying, Ji, Yong, Wang, Luning, Cheng, Yan, Peng, Ying, Ye, Qinyong, Wang, Xiaoping, Wu, Yuncheng, Qu, Qiumin, Chen, Shengdi, Li, Shuhua, Chen, Wei, Xu, Jun, Peng, Dantao, Zhao, Zhongxin, Li, Yansheng, Zhang, Junjian, Du, Yifeng, Chen, Weixian, Fan, Dongsheng, Yan, Yong, Liu, Xiaowei, Zhang, Wei, Luo, Benyan, Wu, Wenyuan, Shen, Lu, Liu, Chunfeng, Mao, Peixian, Wang, Qiumei, Zhao, Qianhua, Guo, Qihao, Zhou, Yongtao, Li, Yi, Jiang, Lijun, Ren, Wenwei, Ouyang, Yingjun, Wang, Yan, Liu, Shuai, Jia, Jianjun, Zhang, Nan, Liu, Zhonglin, He, Raoli, Feng, Tingyi, Lu, Wenhui, Tang, Huidong, Gao, Ping, Zhang, Yingchun, Chen, Lanlan, Wang, Lei, Yin, You, Xu, Qun, Xiao, Jinsong, Cong, Lin, Cheng, Xi, Zhang, Hui, Gao, Dan, Xia, Minghua, Lian, Tenghong, Peng, Guoping, Zhang, Xu, Jiao, Bin, Hu, Hua, Chen, Xueyan, Guan, Yihui, Cui, Ruixue, Huang, Qiu, Xin, Xianliang, Chen, Hongjian, Ding, Yu, Zhang, Jing, Feng, Teng, Cantillon, Marc, Chen, Kewei, Cummings, Jeffrey L., Ding, Jian, Geng, Meiyu, and Zhang, Zhenxin

Published
2021
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46. Development and analysis of two-dimensional point-ahead angle mechanism for space gravitational-wave detection.

Author

Zhu, Weizhou, Xie, Yong, Qian, Yuchen, Jia, Jianjun, Zhang, Liang, and Wang, Xue

Subjects
GRAVITATIONAL waves, PIEZOELECTRIC actuators, CAPACITIVE sensors, LASER beams, FINITE element method, MICHELSON interferometer, ANGLES
Abstract

To detect low-frequency gravitational waves, it is necessary to eliminate the interference of geo-noise and build a laser interference gravitational-wave detection device in space. Space gravitational-wave detection missions, namely Taiji, LISA, and Tianqin, have been planning to achieve picometer sensitivity on an interferometer arm of several million kilometers to meet the gravitational-wave detection requirements. Because of the orbit evolution and the time delay in interferometer arms, the direction of the transmitted laser beam changes; consequently, a remote telescope cannot receive the laser beam to complete the inter-satellite laser interference. In this study, a two-dimensional point-ahead angle mechanism (2DPAAM) is designed and demonstrated to solve the aforementioned problem. Based on the design concept of aligning the rotation center with the mirror surface center, the 2DPAAM employs a four-link flexible-hinge structure, length expanding and contracting piezoelectric stack actuators, and closed-loop control of capacitive sensors to realize two-dimensional picometer-stable, high-precision rotation. A static model is established to analyze the rotational characteristics, and finite element analysis is performed to study the mechanical properties and to verify the rotational characteristics. The yaw and pitch stiffness errors are ∼0.93% and 5.9%, respectively, when the theoretical results are compared with the simulation results. A series of experiments are conducted on the developed 2DPAAM, and the results show that the rotary ranges of yaw and pitch motions attain ±270 and ±268 µrad, respectively. The rotational accuracies of both yaw and pitch motions attain ∼0.35 µrad, and the optical path difference is less than 10 pm / Hz when the frequency is between 1 mHz and 1 Hz, by analogy. [ABSTRACT FROM AUTHOR]

Published
2024
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