Search

Your search keyword '"Ji, Yuanyuan"' showing total 482 results
Start Over Author "Ji, Yuanyuan" Language english
482 results on '"Ji, Yuanyuan"'

27. Nucleus accumbens D1/D2 circuits control opioid withdrawal symptoms in mice

Author

Zhu, Yongsheng, Wang, Kejia, Ma, Tengfei, Ji, Yuanyuan, Lou, Yin, Fu, Xiaoyu, Lu, Ye, Liu, Yige, Dang, Wei, Zhang, Qian, Yin, Fangyuan, Wang, Kena, Yu, Bing, Zhang, Hongbo, Lai, Jianghua, and Wang, Yunpeng

Subjects
Morphine -- Health aspects, Health care industry
Abstract

The nucleus accumbens (NAc) is the most promising target for drug use disorder treatment. Deep brain stimulation (DBS) of NAc is effective for drug use disorder treatment. However, the mechanisms by which DBS produces its therapeutic effects remain enigmatic. Here, we define a behavioral cutoff criterion to distinguish depressive-like behaviors and nondepressivelike behaviors in mice after morphine withdrawal. We identified a basolateral amygdala (BLA) to NAc D1 medium spiny neuron (MSN) pathway that controls depressive-like behaviors after morphine withdrawal. Furthermore, the paraventricular nucleus of thalamus (PVT) to NAc D2 MSN pathway controls naloxone-induced acute withdrawal symptoms. Optogenetically induced long-term potentiation with K-opioid receptor (KOR) antagonism enhanced BLA to NAc D1 MSN signaling and also altered the excitation/inhibition balance of NAc D2 MSN signaling. We also verified that a new 50 Hz DBS protocol reversed morphine withdrawal-evoked abnormal plasticity in NAc. Importantly, this refined DBS treatment effectively alleviated naloxone-induced withdrawal symptoms and depressive-like behaviors and prevented stress-induced reinstatement. Taken together, the results demonstrated that input- and cell type-specific synaptic plasticity underlies morphine withdrawal, which may lead to novel targets for the treatment of opioid use disorder., Introduction Opioid drugs are powerful analgesics, but they are also highly addictive due to the elicitation of powerful euphoria. Opioid use disorder depends not only on its positive reinforcement effects, [...]

Published
2023
Full Text
View/download PDF

28. Effects of sleep quality on suicide risk in COVID-19 patients: The chain mediating of anxiety and depressive symptoms

Author

Yang Yiyue, Gu Kaiqi, Wang Rujie, Liu Honghong, Ming Xu, Feng Yingxue, Peng Yijing, Chen Yu, Ji Yuanyuan, Ma Jing, Li Dongxiao, Lu Yue, and Li Jing

Subjects
COVID-19, Sleep quality, Suicide risk, Depressive symptom, Anxiety symptom, Mediation, Science (General), Q1-390, Social sciences (General), H1-99
Abstract

Background: Although current studies have identified sleep disorders as an independent risk factor for suicide, the relationship between sleep disorders and suicide risk has not been well established. This study explored whether anxiety and depressive symptoms are used as mediators to participate in the impact of sleep quality on suicide risk. Methods: This is a cross-sectional study. We administered a psychological questionnaire to the participants, using a combination of self-assessment and psychiatrist assessment.Sleep quality, suicide risk, level of anxiety and depressive symptoms were assessed by PSQI, NGASR, SAS and SDS.The study subjects were 391 hospitalized COVID-19 patients from Wuhan hospitals. We used model 6 in the PROCESS (version 3.5) plug-in of SPSS software to conduct mediation test with sleep quality as the independent variable, suicide risk as the dependent variable, level of anxiety and depressive symptoms as intermediate variables. Results: The severity of anxiety and depressive symptoms and the risk of suicide in the sleep disorder group (63.15 ± 13.71, 59.85 ± 13.38, 6.52 ± 3.67) were higher than those in the non-sleep disorder group (49.83 ± 13.14, 44.87 ± 10.19, 2.87 ± 3.26) (P

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results