Search

Your search keyword '"Jensen, Ulf"' showing total 111 results
Start Over Author "Jensen, Ulf" Language english
111 results on '"Jensen, Ulf"'

3. Direct or subacute coronary angiography in out-of-hospital cardiac arrest (DISCO)—An initial pilot-study of a randomized clinical trial

Author

Elfwén, Ludvig, Lagedal, Rickard, Nordberg, Per, James, Stefan, Oldgren, Jonas, Böhm, Felix, Lundgren, Peter, Rylander, Christian, van der Linden, Jan, Hollenberg, Jacob, Erlinge, David, Cronberg, Tobias, Jensen, Ulf, Friberg, Hans, Lilja, Gisela, Larsson, Ing-Marie, Wallin, Ewa, Rubertsson, Sten, and Svensson, Leif

Published
2019
Full Text
View/download PDF

13. Does the Position of Foot-Mounted IMU Sensors Influence the Accuracy of Spatio-Temporal Parameters in Endurance Running?

Author

Zrenner, Markus, Küderle, Arne, Roth, Nils, Jensen, Ulf, Dümler, Burkhard, and Eskofier, Bjoern M.

Subjects
Hardware_MEMORYSTRUCTURES, sport science, Foot, foot kinematics, inertial measurement unit, ComputingMilieux_PERSONALCOMPUTING, wearable computing, lcsh:Chemical technology, Article, Biomechanical Phenomena, Shoes, Wearable Electronic Devices, Spatio-Temporal Analysis, zero velocity update, ddc:000, Physical Endurance, running, Humans, lcsh:TP1-1185, sensor position
Abstract

Wearable sensor technology already has a great impact on the endurance running community. Smartwatches and heart rate monitors are heavily used to evaluate runners&rsquo, performance and monitor their training progress. Additionally, foot-mounted inertial measurement units (IMUs) have drawn the attention of sport scientists due to the possibility to monitor biomechanically relevant spatio-temporal parameters outside the lab in real-world environments. Researchers developed and investigated algorithms to extract various features using IMU data of different sensor positions on the foot. In this work, we evaluate whether the sensor position of IMUs mounted to running shoes has an impact on the accuracy of different spatio-temporal parameters. We compare both the raw data of the IMUs at different sensor positions as well as the accuracy of six endurance running-related parameters. We contribute a study with 29 subjects wearing running shoes equipped with four IMUs on both the left and the right shoes and a motion capture system as ground truth. The results show that the IMUs measure different raw data depending on their position on the foot and that the accuracy of the spatio-temporal parameters depends on the sensor position. We recommend to integrate IMU sensors in a cavity in the sole of a running shoe under the foot&rsquo, s arch, because the raw data of this sensor position is best suitable for the reconstruction of the foot trajectory during a stride.

Published
2020
Full Text
View/download PDF

14. Thrombus Aspiration during ST-Segment Elevation Myocardial Infarction

Author

Fröbert, Ole, Lagerqvist, Bo, Olivecrona, Göran K., Omerovic, Elmir, Gudnason, Thorarinn, Maeng, Michael, Aasa, Mikael, Angerås, Oskar, Calais, Fredrik, Danielewicz, Mikael, Erlinge, David, Hellsten, Lars, Jensen, Ulf, Johansson, Agneta C., Kåregren, Amra, Nilsson, Johan, Robertson, Lotta, Sandhall, Lennart, Sjögren, Iwar, Östlund, Ollie, Harnek, Jan, and James, Stefan K.

Published
2013
Full Text
View/download PDF

19. Incorporating Data Science into IoT New Product Development: A Review.

Author

Häusler, Elisabeth, Kremser, Wolfgang, Hornung-Prähauser, Veronika, Jensen, Ulf, and Huber, Franz

Subjects
DATA science, INTERNET of things, NEW product development, PRODUCT management, KNOWLEDGE gap theory
Abstract

Developing novel data-intensive products and services comes with a degree of unpredictability and invention risk. As domain understanding develops alongside data analytics capabilities, specialists from engineering, science, and industry have to cooperate, each with their own perspective on the product’s design. In this highly complex and interdisciplinary context, product managers have to understand what it takes to turn data into value. This review identifies current concepts in IoT new product development and investigates how they overlap with the data-value chain, a reference model for data-based value creation. Our findings indicate that none of the reviewed NPD-process models covers the data-value chain in its entirety. We highlight knowledge gaps that might lead to the underestimation of invention risk, which may cause costly redesigns late in the project. [ABSTRACT FROM AUTHOR]

Published
2021

20. Effective cholesterol lowering after myocardial infarction in patients with nephrotic syndrome may require a multi-pharmacological approach: a case report.

Author

Sjuls, Simon, Jensen, Ulf, Littmann, Karin, Bruchfeld, Annette, and Brinck, Jonas

Subjects
MYOCARDIAL infarction, NEPHROTIC syndrome, CHOLESTEROL
Abstract

Background Nephrotic syndrome causes severe hypercholesterolaemia due to increased production and altered clearance of lipoproteins from the liver. It is challenging for patients with nephrotic syndrome and coronary heart disease to meet LDL-cholesterol (LDL-C) goals for secondary prevention with conventional lipid-lowering therapy. Case summary We present a man with nephrotic syndrome caused by focal segmental glomerular sclerosis (FSGS) and hypercholesterolaemia. He presented at the emergency room (ER) with an ST-elevation myocardial infarction at the age of 26. On follow-up, the patient had persistent hypercholesterolaemia [LDL-C 3.9 mmol/L and lipoprotein(a) 308 nmol/L] despite a combination of lipid-lowering therapy with atorvastatin 80 mg/day and ezetimibe 10 mg/day. Addition of the proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitory antibody evolocumab 140 mg bi-monthly did not improve cholesterol levels. However, after addition of the sodium-glucose cotransporter 2 (SGLT2) inhibitor empagliflozin 10 mg/day on top of other anti-proteinuric treatments, the patient's proteinuria was reduced and a dramatic drop in LDL-C level by 3.2–0.6 mmol/L (−81%) was observed when evolocumab was re-introduced. Discussion We show that target LDL-C levels were obtained in this patient with therapy-resistant FSGS and hypercholesterolaemia following multi-pharmacological treatment with SGLT2 and PCSK9 inhibitors on top of conventional lipid-lowering therapy. The SGLT2-inhibitor reduced proteinuria and, speculatively, also reduced urinary loss of PCSK9-antibody. Therefore, in patients with nephrotic syndrome and cardiovascular disease novel therapeutic options to manage proteinuria could be considered to improve the efficacy of the lipid-lowering therapy, especially when the protein-based PCSK9 inhibitors are used. [ABSTRACT FROM AUTHOR]

Published
2021
Full Text
View/download PDF

21. Comparison of Different Algorithms for Calculating Velocity and Stride Length in Running Using Inertial Measurement Units

Author

Zrenner, Markus, Gradl, Stefan, Jensen, Ulf, Ullrich, Martin, and Eskofier, Bjoern M.

Subjects
Male, velocity, Anthropometry, Foot, wearable sensors, inertial measurement unit, Acceleration, Decision Making, Technische Fakultät, gait, lcsh:Chemical technology, Article, Shoes, Motion, smart shoe, running, Humans, Female, lcsh:TP1-1185, Rheology, stride length, ddc:600, Algorithms
Abstract

Running has a positive impact on human health and is an accessible sport for most people. There is high demand for tracking running performance and progress for amateurs and professionals alike. The parameters velocity and distance are thereby of main interest. In this work, we evaluate the accuracy of four algorithms, which calculate the stride velocity and stride length during running using data of an inertial measurement unit (IMU) placed in the midsole of a running shoe. The four algorithms are based on stride time, foot acceleration, foot trajectory estimation, and deep learning, respectively. They are compared using two studies: a laboratory-based study comprising 2377 strides from 27 subjects with 3D motion tracking as a reference and a field study comprising 12 subjects performing a 3.2-km run in a real-world setup. The results show that the foot trajectory estimation algorithm performs best, achieving a mean error of 0.032 &plusmn, 0.274 m/s for the velocity estimation and 0.022 &plusmn, 0.157 m for the stride length. An interesting alternative for systems with a low energy budget is the acceleration-based approach. Our results support the implementation decision for running velocity and distance tracking using IMUs embedded in the sole of a running shoe.

Published
2018

22. Gesichtspunkte zum Entwurf und Anwendungsbeispiele eingebetteter Klassifikationssysteme

Author

Jensen, Ulf

Subjects
Schwimmen, Intelligente Bekleidung, Putten Golf, Kostenschätzung, Mustererkennung, Department Informatik, Sportkleidung, ddc:006, Body Area Network
Abstract

Wearable athlete support systems are a popular technology for performance enhancement in sports. The complex signal and data analysis on these systems is often tackled with pattern recognition techniques like classification. The implementation of classification algorithms on mobile hardware is called embedded classification. Thereby, technical challenges arise from the restricted computational power, battery capacity and size of such mobile systems. The accuracy-cost tradeoff describes the two conflicting design goals of embedded classification systems; the accuracy and the computational cost of a classifier. A data analysis system should be as accurate as possible and, at the same time, as cheap as required for an implementation on a mobile system with restricted resources. Thus, accuracy and cost have to be simultaneously considered in the design phase of the algorithms. Furthermore, an accurate modeling of classification systems, a precise estimation of the expected accuracy and energy efficient algorithms are needed. The first main goal of this thesis was to develop design considerations to support the solution of the accuracy-cost tradeoff that occurs during embedded classification system design. The success of wearable technology in sports originates in several application opportunities. A wearable system can collect data in the field without the restrictions of a lab environment or capture volume. Data with realistic variation and a high number of trials can be used to analyze the true field performance as well as its long-term progress over time. Real-time data processing allows to support athletes and coaches with augmented feedback in the field. Therefore, wearable systems enable new opportunities for the analysis of athletic performance. The second main goal of this thesis was to illustrate the benefits and opportunities of wearable athlete support systems with three application examples. This thesis presents applications for plyometric training, golf putting and swimming. The applications were realized as body sensor networks (BSNs) and analyzed kinematic data that were acquired with inertial measurement units (IMUs). The plyometric training application targeted the ground contact time calculation in drop jump exercises. The presented algorithm used a hidden markov model to calculate the ground contact with high accuracy. The ground contact time is an important training parameter to assess athlete performance and cannot be visually assessed. The golf putt application realized a system for technique training in the field. It featured an algorithm for automatic putt detection and parameter extraction as a basis for augmented feedback training applications. Long-term kinematic golf training data provided new insights in the progress of golf putting. The swimming application realized an unobtrusive swimming exercise tracker. The system was able to classify the four swimming styles, turns and breaks based on the head kinematics. Furthermore, an algorithm to classify long-term fatigue that occurs in a 90 min swimming exercise was presented. The swimming style, turn and break classification was implemented as embedded classification system on a BSN sensor node. This application underlines the applicability of the presented design considerations for solving the accuracy-cost tradeoff. The contributions of this thesis are considerations for the design of embedded classification systems and application examples that illustrate the benefits of wearable athlete support systems. The focus was to provide practical support for the solution of the accuracy-cost tradeoff and to present the technical realization of wearable athlete support systems. The findings of this thesis can be beneficial for research as well as industrial applications in the sport, health and medical domain. Tragbare Sportler-Assistenz-Systeme sind eine weit verbreitete Technologie zur Leistungssteigerung im Sport. Die komplexe Signal- und Datenverarbeitung auf diesen Systemen wird dabei oft mit Methoden der Mustererkennung, wie Klassifikation, bewerkstelligt. Die Implementierung von Klassifikationsalgorithmen auf mobiler Hardware nennt man eingebettete Klassifikation. Technische Herausforderungen entstehen hierbei durch die limitierte Rechenleistung, Batteriekapazität und Größe mobiler Systeme. Der Accuracy-Cost-Tradeoff beschreibt die beiden konkurrierenden Entwurfsziele von eingebetteten Klassifikationssystemen: die Genauigkeit und die Berechnungskosten eines Klassifikators. Ein Datenanalyse-System soll die maximale Genauigkeit erreichen und gleichzeitig auf einem mobilen System mit limitierten Ressourcen implementiert werden können. Genauigkeit und Kosten müssen daher in der Entwurfsphase von Algorithmen parallel betrachtet werden. Zudem ist es nötig, Klassifikationssysteme akkurat zu Modellieren, ihre zu erwartende Genauigkeit präzise abzuschätzen und ihre Energieeffizienz im Entwurf zu berücksichtigen. Das erste Ziel dieser Arbeit war es, die Lösung des Accuracy-Cost-Tradeoffs beim Entwurf eingebetteter Klassifikationssysteme mit verschiedenen Gesichtspunkten zu unterstützen. Der Erfolg tragbarer Systeme im Sport basiert auf verschiedenen Chancen dieser Technologie. So kann ein tragbares System Felddaten aufzeichnen und ist nicht auf eine Laborumgebung oder einen Messplatz beschränkt. Es kann eine große Datenmenge mit realitätsnaher Variation genutzt werden, um die Leistung im Feld und deren Langzeitverlauf zu analysieren. Die Verarbeitung der Daten in Echtzeit erlaubt es, den Sportler und den Trainer im Feld mit extrinsischem Feedback zu unterstützen. Tragbare Systeme eröffnen daher neue Möglichkeiten sportliche Leistung zu analysieren. Das zweite Ziel dieser Arbeit war es, diese Möglichkeiten anhand von drei Anwendungen zu verdeutlichen um den Mehrwert der Systeme zu unterstreichen. In dieser Arbeit werden mobile Anwendungen für plyometrisches Training, Golf Putting und Schwimmen vorgestellt. Sie bestehen aus Netzwerken drahtloser, körpernaher Inertialsensoren mittels derer kinematische Daten mobil verarbeitet werden können. Die Anwendung für plyometrisches Training berechnete die Bodenkontaktzeit bei Niedersprügen. Der Datenanalyse-Algorithmus verwendete dabei ein Hidden Markov Modell, um den auftretenden Bodenkontakt mit hoher Genauigkeit zu ermitteln. Die Bodenkontaktzeit ist ein wichtiger Trainingsparameter zur Beurteilung der Sprungleistung und visuell nicht zu ermitteln. Die Golf Putting Anwendung beschreibt ein System zum Techniktraining beim Golf. Der entwickelte Algorithmus zur automatischen Erkennung von Schlägen und Berechnung von Schlagparametern stellt die Basis für Anwendungen mit extrinsischem Feedback dar. Langzeitaufzeichnungen von kinematischen Daten während des Golftrainings lieferten im Rahmen dieser Arbeit neue Einblicke in die Entwicklung der Schlagtechnik. Die Schwimmanwendung stellt ein dezentes System zur Trainingsüberwachung vor. Es war in der Lage die vier verschiedenen Schwimmstile sowie Wenden und Pausen anhand der Kopfkinematik zu unterscheiden. Außerdem konnte mit dem System die Langzeitermüdung eines 90-minütigen Schwimmtrainings erkannt werden. Die Erkennung der Schwimmstile, Wenden und Pausen wurde als eingebettetes Klassifikationsystem auf einem tragbaren Sensorknoten implementiert. Diese Anwendung unterstreicht daher die Eignung der entwickelten Gesichtspunkte zur Lösung des Accuracy-Cost-Tradeoffs. Diese Arbeit stellt verschiedene Gesichtspunkte zum Entwurf eingebetteter Klassifikationssysteme vor und unterstreicht anhand von Anwendungsbeispielen den Mehrwert tragbarer Sportler-Assistenz-Systeme. Der Fokus lag auf einer anwendungsorientierten Unterstützung zur Lösung des Accuracy-Cost-Tradeoffs und auf der technischen Umsetzung tragbarer Sportler-Assistenz-Systeme. Von den Erkenntnissen dieser Arbeit können sowohl Forschung als auch Industrie aus den Bereichen Sport, Gesundheit und Medizin profitieren.

Published
2016

23. The MOVEMENT Trial.

Author

Holm, Manne, Tornvall, Per, Henareh, Loghman, Jensen, Ulf, Golster, Nanna, Alström, Patrik, Santos-Pardo, Irene, Witt, Nils, Fedchenko, Nikolai, Venetsanos, Dimitrios, Beck, Olof, and van der Linden, Jan

Published
2019
Full Text
View/download PDF

24. Stent thrombosis in new-generation drug-eluting stents in patients with STEMI undergoing primary PCI:A report from SCAAR

Author

Sarno, Giovanna, Lagerqvist, Bo, Nilsson, Johan, Frobert, Ole, Hambraeus, Kristina, Varenhorst, Christoph, Jensen, Ulf J., Tödt, Tim, Götberg, Matthias, and James, Stefan K.

Subjects
ST-segment elevation myocardial infarction, percutaneous coronary intervention, cardiovascular diseases, drug-eluting stent(s)
Abstract

BACKGROUND: Some concerns still have not been resolved about the long-term safety of drug-eluting stents (DES) in patients with acute STEMI. OBJECTIVES: The aim of this study was to evaluate the stent thrombosis (ST) rate up to 3 years in patients with ST-segment elevation myocardial infarction (STEMI) treated by primary percutaneous coronary intervention (PCI) with new-generation drug-eluting stents (n-DES) compared with bare-metal stents (BMS) and old-generation drug-eluting stents (o-DES) enrolled in the SCAAR (Swedish Coronary Angiography and Angioplasty Registry). METHODS: From January 2007 to January 2013, 34,147 patients with STEMI were treated by PCI with n-DES (n = 4,811), o-DES (n = 4,271), or BMS (n = 25,065). The risks of early/late (up to 1 year) and very late definite ST (after 1 year) were estimated. RESULTS: Cox regression landmark analysis showed a significantly lower risk of early/late ST in patients treated with n-DES (hazard ratio [HR]: 0.65; 95% confidence interval [CI]: 0.43 to 0.99; p = 0.04) and o-DES (HR: 0.60; 95% CI: 0.41 to 0.89; p = 0.01) compared with the BMS group. The risk of very late ST was similar between the n-DES and BMS groups (HR: 1.52; 95% CI: 0.78 to 2.98; p = 0.21), whereas a higher risk of very late ST was observed with o-DES compared with BMS (HR: 2.88; 95% CI: 1.70 to 4.89; p < 0.01). CONCLUSIONS: Patients treated with n-DES have a lower risk of early/late ST than patients treated with BMS. The risk of very late ST is low and comparable between n-DES and BMS up to 3 years of follow-up, whereas o-DES treatment is associated with an increased risk of very late ST. The current STEMI guidelines might require an update in light of the results of this and other recent studies.

Published
2014

25. Optimal Allocation of Reviewers for Peer Feedback.

Author

Wind, David Kofoed, Jensen, Ulf Aslak, Jørgensen, Rasmus Malthe, Hansen, Simon Lind, and Winther, Ole

Subjects
PSYCHOLOGICAL feedback, EDUCATIONAL quality, RATING of students, LEARNING management, FACILITATED learning
Abstract

Peer feedback is the act of letting students give feedback to each other on submitted work. There are multiple reasons to use peer feedback, including students getting more feedback, time saving for teachers and increased learning by letting students reflect on work by others. In order for peer feedback to be effective students should give and receive useful feedback. A key challenge in peer feedback is allocating the feedback givers in a good way. It is important that reviewers are allocated to submissions such that the feedback distribution is fair - meaning that all students receive good feedback. In this paper we present a novel way to intelligently allocate reviewers for peer feedback. We train a statistical model to infer the quality of feedback based on a dataset of feedback quality evaluations. This dataset contains more than 20,000 reviews where the receiver of the feedback has indicated the quality of the feedback. Using this model together with historical data we calculate the feedback-giving skill of each student and uses that as input to an allocation algorithm that assigns submissions to reviewers, in order to optimize the feedback quality for all students. We test the performance of our allocation strategy using real data from over 600 peer feedback sessions and simulate the effects of different allocation strategies. By comparing our method with a random allocation algorithm and a "super-informed oracle" algorithm we demonstrate that we are able to allocate reviewers to submissions in such a way that all submissions receive feedback of similar quality and that we are able to significantly outperform simple random allocation of reviewers. Additionally we investigate the effect of pre-allocating reviews in comparison to allocating reviewers live during the review process and show that live-allocation leads to better results. Our method is robust to reviews not being completed and other real-life quirks and improves as more feedback data is collected. [ABSTRACT FROM AUTHOR]

Published
2017

26. Quantifying Feedback: Insights Into PeerAssessment Data.

Author

Wind, David Kofoed and Jensen, Ulf Aslak

Subjects
PEER review of students, RATING of students, PSYCHOLOGICAL feedback, REPORT writing, DATA analysis
Abstract

The act of producing content - for example in forms of written reports - is one of the most used methods for teaching and learning all the way from primary school to university. It is a learning tool which helps students relate their theories to practice. Getting relevant and helpful feedback on this work is important to ensure a good learning experience for the students. Providing this feedback is often a time-consuming job for the teacher. An effective way to learn is to teach others, and similarly give feedback on work done by others. One way to approach a combined solution to the above challenges, is to use peer assessment in the classroom which as a learning method has become more and more popular. In this paper we look at data collected using the web-based peer assessment system Peergrade. The dataset consists of over 350 courses at more than 20 educational institutions and with a total of more than 10,000 students. The students have together made more than 100,000 peer-evaluations of work by other students, and these evaluations together contain more than 10,000,000 words of text feedback. A key problem when using peer assessment is to ensure high quality feedback between peers. Feedback here can be a combination of quantitative / summative feedback (numerical) and qualitative / formative feedback (text). A lot of work has been done on validating and ensuring quality of quantitative feedback. We propose a way to let students evaluate the quality of the feedback they receive to obtain a quality measure for the feedback. We investigate this measure of feedback quality, which biases are present and what trends can be observed across the dataset. Using our measure of feedback quality, we investigate how it relates to various factors like the length of the feedback text, the number of spelling mistakes, how positive it is and measures of the student's report-writing skills. [ABSTRACT FROM AUTHOR]

Published
2017

27. Coronary angiography in out-of-hospital cardiac arrest without ST elevation on ECG-Short- and long-term survival.

Author

Elfwén, Ludvig, Lagedal, Rickard, James, Stefan, Jonsson, Martin, Jensen, Ulf, Ringh, Mattias, Claesson, Andreas, Oldgren, Jonas, Herlitz, Johan, Rubertsson, Sten, and Nordberg, Per

Abstract

Background: The potential benefit of early coronary angiography in out-of-hospital cardiac arrest (OHCA) patients without ST elevation on ECG is unclear. The aim of this study was to evaluate the association between early coronary angiography and survival in these patients.Methods: Nationwide observational study between 2008 and 2013. Included were patients admitted to hospital after witnessed OHCA, with shockable rhythm, age 18 to 80 years and unconscious. Patients with ST-elevation on ECG were excluded. Patients that underwent early CAG (within 24 hours) were compared with no early CAG (later during the hospital stay or not at all). Outcomes were survival at 30 days, 1 year, and 3 years. Multivariate analysis included pre-hospital factors, comorbidity and ECG-findings.Results: In total, 799 OHCA patients fulfilled the inclusion criteria, of which 275 (34%) received early CAG versus 524 (66%) with no early CAG. In the early CAG group, the proportion of patients with an occluded coronary artery was 27% and 70% had at least one significant coronary stenosis (defined as narrowing of coronary lumen diameter of ≥50%). The 30-day survival rate was 65% in early CAG group versus 52% with no early CAG (P < .001). The adjusted OR was 1.42 (95% CI 1.00-2.02). The one-year survival rate was 62% in the early CAG group versus 48% in the no early CAG group with the adjusted hazard ratio of 1.35 (95% CI 1.04-1.77).Conclusion: In this population of bystander-witnessed cases of out-of-hospital cardiac arrest with shockable rhythm and ECG without ST elevation, early coronary angiography may be associated with improved short and long term survival. [ABSTRACT FROM AUTHOR]

Published
2018
Full Text
View/download PDF

28. Changes Of Cerebral Haemodynamics During Music Perception: Functional Transcranial Doppler Study

Author

Antić, Sonja, Vuković, Vlasta, Jensen, Ulf, Fritzer E, Budišić, Mislav, Lovrenčić Huzjan, Arijana, Morović, Sandra, Jurašić, Miljenka Jelena, and Demarin, Vida

Subjects
music, transcranial Doppler, diagnostics, cardiovascular system, otorhinolaryngologic diseases, behavioral disciplines and activities, psychological phenomena and processes, humanities
Abstract

BACKGROUND: Recent studies have shown that the perception of musical information involves both cerebral hemispheres. The aim of our study was to determine the time course and lateralization of changes in mean blood flow velocity (MBFV) in the middle cerebral artery (MCA) during auditory stimulation. METHODS: Using transcranial Doppler (TCD) we assessed MBFV in 61 healthy right-handed subjects (20 male and 41 female) with or without musical education. First the left MCA was insonated and the subjects listened 2 minutes to a relaxing musical piece, after a pause the same was repeated with the right MCA. Half of the subjects were asked to relax during listening to music (passive group), the other half was asked to pay attention to the musical sounds (active group). RESULTS: The following statistically significant differences (p

Published
2006

29. Changes of Cerebral Haemodynamics During Music Perception in Musically Educated and Musically Non-Educated Listeners

Author

Antić, Sonja, Lovrenčić Huzjan, Arijana, Jensen, Ulf, Fritzer, E, Vuković, Vlasta, Budišić, Mislav, Morović, Sonja, Jurašić, Miljenka Jelena, and Demarin, Vida

Subjects
human activities, behavioral disciplines and activities, humanities, Music, transcranial Doppler (TCD), musical education
Abstract

Background: Several studies have shown that the perception of musical information differs between musically educated and musically non-educated individuals. The aim of our study was to determine the differences and and lateralization of changes in mean blood flow velocity (MBFV) in the middle cerebral artery (MCA) during auditory stimulation between musically educated and musically non- educated listeners. Methods: Using transcranial Doppler (TCD) we assessed MBFV in 61 healthy right-handed subjects (18 musical educated, 43 musically noneducated). The ability to play an instrument was considered the minimum criterion for musical education. First the left MCA was insolated and the subjects listened 2 minutes to a relaxing musical piece, after a pause the same was repeated with the right MCA. Half ~f the subjects were asked to relax during listening to music (passive group), the other half was asked to pay attention to the musical sounds (active group). Mann-Withney-U test was used for statistical analysis. Results: In both, musically educated and non-educated groups left MCA was activated earlier (p=0.046) and had higher MBFV (p=0.013). There was no difference in habituation in the left MCA between these two groups. In right MCA habituation was obtained earlier in musically educated than in musically non-educated group (p=0.019). Musically educated active listeners had higher MBFV in right MCA than passive listeners (p=0.028). Conclusion: Our data suggest that music perception requires bilateral activation of cerebral hemispheres. The left hemisphere is firstly and predominantly activated regardless of musical education, while right hemisphere is associative and Is connected to experience of music.

Published
2006

30. 135 The Differences Between Females and Males in Music Perception: A Fundional Transcranial Doppler Study

Author

Vuković, Vlasta, Antić, Sonja, Jensen, Ulf, Fritzer, E, Lovrenčić Huzjan, Arijana, Budisić, Mislav, Morović, Sandra, Jurašić, Miljenka Jelena, and Demarin, Vida

Subjects
Music perceptoin, transcranial Doppler, gender differences, cardiovascular system, humanities
Abstract

Background: Several studies have focused: on the differences in music perception regarding hemispheric dominance and musical education, but to the best of our knowledge none of them investigated gender difference. The aim of our study was to determine the differences and lateralization of changes in mean blood flow velocity (MBFV) in the middle cerebral artery (MCA) during auditory stimulation between female and male listeners. Methods: Using transcranial Doppler (TCD) we assessed MBFV in 61 healthy right-handed subjects (41 female, and 20 male). First the left MCA was insonated and the subjects listened 2 minutes to a relaxing musical piece, after a pause the same was repeated with the right MCA. Time (T1 max) and amplitude (A1 max) of first maximum response of MBFV in MCA was measured as well as maximum amplitude (Amax) of MCA's MBFV and the time (Tmax) to obtain it. Mann-Withney-U test was used for statistical analysis. Results: Female listeners had shorter Tmax in the left MCA than in the right (p=0.002), while in males no difference was found. Male listeners had longer T1 max in the left MCA (p=0.003) and higher A1 max in the right MCA (p= 0.038) than female listeners. Also the Tmax in the left MCA was longer in the male than female listeners (0.013). However no difference was found in Amax in both MCAs between those two groups. Condusion: Both cerebral hemispheres are involved in music perception in both females and males and only slight differences by means of functional TCD were obtained Further studies involving larger groups are needed.

Published
2006

31. Changes of Cerebral Hemodynamics During Music Perception: A Functional Transcranial Doppler Study

Author

Antić, Sonja, Jensen, Ulf, Lovrenčić-Huzjan, Arijana, Vuković, Vlasta, Mukhtarova, Roxana, Verónica, Sandra, Sáo, Ferreira, González, Roberto Trevi&#241, o, Jurašić, Miljenka-Jelena, Santos, Silva, Morović, Sandra, and Demarin, Vida

Subjects
Slušna percepcija - fiziologija, Cerebrovaskularna cirkulacija - fiziologija, Glazba, Ultrazvuk - Dopplerov - transkranijski
Abstract

Studije su pokazale da se percepcija glazbe razlikuje između glazbeno obrazovanih i glazbeno neobrazovanih osoba. Svrha studije je bila utvrditi vremenski slijed i lateralizaciju promjena u srednjoj vrijednosti strujanja krvi (SBSK) u arteriji cerebri mediji (ACM) kako između glazbeno obrazovanih i glazbeno neobrazovanih ispitanika, tako i između spolova za vrijeme slušne stimulacije. Kod 61 zdravog dešnjaka (18 glazbeno obrazovanih, 43 glazbeno neobrazovanih) pratila se SBSK pomoću transkranijskog Dopplera (TCD). Sposobnost sviranja instrumenta je bio minimalni kriterij glazbene izobrazbe. U objema skupinama glazbeno obrazovanih i glazbeno neobrazovanih ispitanika lijeva ACM se aktivirala ranije (p=0, 013), a SBSK je bila viša u lijevoj ACM (p=0, 046). Nije bilo razlike u habituaciji u lijevoj ACM između ovih dviju skupina. U desnoj ACM je kod glazbeno neobrazovanih došlo ranije do habituacije nego kod glazbeno obrazovanih (p=0, 019). Kod žena je zabilježena brža aktivacija SBSK u lijevoj ACM nego u desnoj (p=0, 002), dok kod muškaraca nije nađena razlika. Muški ispitanici su imali duže razdoblje prve aktivacije u lijevoj ACM (p=0, 003) i višu amplitudu prve reakcije u desnoj ACM (p=0, 038) nego ispitanice. Vrijeme reakcije SBSK u lijevoj ACM je također bilo duže u muških nego u ženskih ispitanika (p=0, 013). Naši rezultati upućuju na to da je za percepciju glazbe potrebna aktivacija obiju hemisfera. Pretežito i prvenstveno se aktivira lijeva moždana hemisfera bez obzira na glazbenu izobrazbu, dok desna moždana hemisfera ima više asocijativnu funkciju i povezana je s glazbenim iskustvom. Kod muškaraca i žena su uz pomoć funkcionalnog TCD također zabilježene razlike u precepciji. Za potvrdu ovih preliminarnih rezultata našega istraživanja potrebno je proširiti istraživanje na veći broj ispitanika.

Published
2006

33. Unobtrusive and Energy-Efficient Swimming Exercise Tracking Using On-Node Processing.

Author

Jensen, Ulf, Blank, Peter, Kugler, Patrick, and Eskofier, Bjoern M.

Abstract

Body-worn sensors for movement analysis in swimming have to be unobtrusive and energy-efficient. We present a swimming exercise tracker for the unobtrusive positioning at the back of the head and an energy-efficient analysis using an on-node implementation. To develop the system, we collected head kinematics from 11 subjects in two 200-m medley races comprising breaks, turns, and four swimming styles. Each subject was equipped with a 6-D inertial measurement unit and completed one session in rested and fatigued state. Data were analyzed with a classification system, whereby different classifiers, window sizes, and feature sets were evaluated. Algorithm selection for on-node processing was performed on the basis of classifier accuracy and computational cost. The algorithm with the best tradeoff in accuracy and computational cost was selected and had a classification rate of 85.4%. Energy consumption of both on-node processing and Bluetooth streaming was evaluated on the Shimmer sensor platform. The results revealed energy savings of over 60% when data were processed on the sensor node. The presented analysis approach can be easily applied to other data analysis tasks, and the presented toolchain can support the rapid development of wearable systems in sports and healthcare. [ABSTRACT FROM PUBLISHER]

Published
2015
Full Text
View/download PDF

36. Software-based performance and complexity analysis for the design of embedded classification systems.

Author

Ring, Matthias, Jensen, Ulf, Kugler, Patrick, and Eskofier, Bjoern

Abstract

Embedded microcontrollers are employed in an increasing number of applications as a target for the implementation of classification systems. This is true for example for the fields of sports, automotive and medical engineering. However, important challenges arise when implementing classification systems on embedded microcontrollers, which is mainly due to limited hardware resources. In this paper, we present a solution to the two main challenges, namely obtaining a classification system with low computational complexity and at the same time high classification accuracy. For the first challenge, we propose complexity measures on the mathematical operation and parameter level, because the abstraction level of the commonly used Landau notation is too high in the context of embedded system implementation. For the second challenge, we present a software toolbox that trains different classification systems, compares their classification rate, and finally analyzes the complexity of the trained system. To give an impression of the importance of such complexity measures when dealing with limited hardware resources, we present the example analysis of the popular Pima Indians Diabetes data set, where considerable complexity differences between classification systems were revealed. [ABSTRACT FROM PUBLISHER]

Published
2012

37. Classification of surfaces and inclinations during outdoor running using shoe-mounted inertial sensors.

Author

Schuldhaus, Dominik, Kugler, Patrick, Jensen, Ulf, Eskofier, Bjoern, Schlarb, Heiko, and Leible, Magnus

Abstract

Embedded mobile systems for analysis and classification become more and more important in the field of sports and sports science. Small and lightweight sensors in sportswear offer the possibility to monitor the athletes in a realistic environment, e.g. during an outdoor run. During the activity, the sportswear can automatically adapt to the current environment and hence optimizes the performance of the athlete. A major need is a running shoe, which can automatically be adapted to the current ground. In this paper, a classification system was developed, which distinguished between different surfaces and inclinations based on inertial sensors. They were placed on the heel of a running shoe and acquired kinematic data of 21 subjects. For each subject, several rounds of an one hour outdoor run were available and were used for the evaluation of the system. The classification system reached a mean classification rate of more than 80 %. [ABSTRACT FROM PUBLISHER]

Published
2012

38. Classification of kinematic golf putt data with emphasis on feature selection.

Author

Jensen, Ulf, Eskofier, Bjoern, and Dassler, Frank

Abstract

The complex movement sequences of golf require supporting tools for players and coaches alike. We developed a system that classifies the experience level and trained it with data from an inertial sensor on the club head. Based on 315 golf putts from eleven subjects the system differentiated between experienced and unexperienced players with a classification rate of 86.1%. To improve the classification system and obtain discriminant features we additionally integrated a feature selection step. We compared different selection approaches and concluded that a leave-subject-out feature selection was the appropriate approach to predict the true performance of a live system. The selected features can be fed back to coaches and help them to guide players to a better putting technique. [ABSTRACT FROM PUBLISHER]

Published
2012

39. Comparison of Multi-service Routing Strategies for IP Core Networks.

Author

Jensen, Ulf and Heindl, Armin

Abstract

Service differentiation in IP core networks may be supported by dedicated path selection rules. This paper investigates the degree of service distinction achievable when common routing strategies, like ECMP, SWP and WSP, are applied to two traffic classes separately and in different combinations. One traffic class requires low latencies, while the other is considered as best-effort traffic. A Maple program has been developed that evaluates network performance characteristics, like maximal link utilization, and per-class measures, like mean end-to-end delay and mean number of hops, when paths are computed on demand with traffic demands arriving in arbitrary order. Realistic network topologies may be imported from the publicly available tool BRITE, while link capacities and traffic patterns are chosen randomly (with realistic constraints) in Maple. Experiments show that a comparable service differentiation may already be achieved with less sophisticated strategy combinations, which apply ECMP to the delay-critical traffic class. [ABSTRACT FROM AUTHOR]

Published
2009
Full Text
View/download PDF

40. Chronic Total Occlusions in Sweden – A Report from the Swedish Coronary Angiography and Angioplasty Registry (SCAAR).

Author

Råmunddal, Truls, Hoebers, Loes, Henriques, Jose P. S., Dworeck, Christian, Angerås, Oskar, Odenstedt, Jacob, Ioanes, Dan, Olivecrona, Göran, Harnek, Jan, Jensen, Ulf, Aasa, Mikael, Jussila, Risto, James, Stefan, Lagerqvist, Bo, Matejka, Göran, Albertsson, Per, and Omerovic, Elmir

Subjects
ARTERIAL occlusions, CORONARY angiography, ANGIOPLASTY, MEDICAL registries, CORONARY artery surgery, CHRONICALLY ill, CHRONIC disease treatment
Abstract

Introduction: Evidence for the current guidelines for the treatment of patients with chronic total occlusions (CTO) in coronary arteries is limited. In this study we identified all CTO patients registered in the Swedish Coronary Angiography and Angioplasty Registry (SCAAR) and studied the prevalence, patient characteristics and treatment decisions for CTO in Sweden. Methods and Results: Between January 2005 and January 2012, 276,931 procedures (coronary angiography or percutaneous coronary intervention) were performed in 215,836 patients registered in SCAAR. We identified all patients who had 100% luminal diameter stenosis known or assumed to be ≥3 months old. After exclusion of patients with previous coronary artery bypass graft (CABG) surgery or coronary occlusions due to acute coronary syndrome, we identified 16,818 CTO patients. A CTO was present in 10.9% of all coronary angiographies and in 16.0% of patients with coronary artery disease. The majority of CTO patients were treated conservatively and PCI of CTO accounted for only 5.8% of all PCI procedures. CTO patients with diabetes and multivessel disease were more likely to be referred to CABG. Conclusion: CTO is a common finding in Swedish patients undergoing coronary angiography but the number of CTO procedures in Sweden is low. Patients with CTO are a high-risk subgroup of patients with coronary artery disease. SCAAR has the largest register of CTO patients and therefore may be valuable for studies of clinical importance of CTO and optimal treatment for CTO patients. [ABSTRACT FROM AUTHOR]

Published
2014
Full Text
View/download PDF

41. The role of a simulator-based course in coronary angiography on performance in real life cath lab.

Author

Jensen, Ulf J., Jensen, Jens, Olivecrona, Göran, Ahlberg, Gunnar, Lagerquist, Bo, and Tornvall, Per

Subjects
CORONARY angiography, CARDIAC catheterization, CARDIOTONIC agents, LEARNING curve, CARDIOLOGISTS
Abstract

Background: The aim of this study was to explore if a course consisting of lectures combined with simulator training in coronary angiography (CA) could accelerate the early learning curve when performing CA on patients. Knowledge in performing CA is included in the curriculum for the general cardiologist. The method, according to American College of Cardiology and European Society of Cardiology guidelines, for this training is not well defined but simulator training is proposed to be an option. However, the transfer effect from a CA simulator to performance in real world cath lab is not validated. Methods: Fifty-four residents without practical skills in CA completed the course and 12 continued to training in invasive cardiology. These residents were tracked in the Swedish Coronary Angiography and Angioplasty Registry and compared to a control group of 46 novel operators for evaluation of performance metrics. A total of 4472 CAs were analyzed. Results: Course participants demonstrated no consistent acceleration in the early learning curve in real world cath lab. They had longer fluoroscopy time compared to controls (median 360 seconds (IQR 245-557) vs. 289 seconds (IQR 179-468), p < 0.001). Safety measures also indicated more complications appearing at the ward, in particular when using the femoral approach (6.25% vs. 2.53%, p < 0.001). Conclusions: Since the results of this retrospective non-randomized study were negative, the role of a structured course including simulator training for skills acquisition in CA is still uncertain. Randomized transfer studies are warranted to justify further use of simulators for training in CA. [ABSTRACT FROM AUTHOR]

Published
2014
Full Text
View/download PDF

44. The correlation between quantitative T2′ and regional cerebral blood flow after acute brain ischemia in early reperfusion as demonstrated in a middle cerebral artery occlusion/reperfusion model of the rat

Author

Jensen, Ulf R., Liu, Jian-Ren, Eschenfelder, Christoph, Meyne, Johannes, Zhao, Yi, Deuschl, Günther, Jansen, Olav, and Ulmer, Stephan

Subjects
*CEREBRAL circulation, *CEREBRAL ischemia, *REPERFUSION injury, *ARTERIAL occlusions, *LABORATORY rats, *ANIMAL models in research, *CEREBROVASCULAR disease
Abstract

Abstract: Introduction: qT2′-maps are calculated by subtracting T2- from T2*-relaxation rates. They are oxygen-sensitive and depict oxygen extraction. In several studies they have been used to describe the penumbra in patients with acute ischemic stroke. No correlation between rCBF and qT2′ has been performed to date. In this study a correlation between rCBF and qT2′ was performed in a temporary middle cerebral occlusion–reperfusion model of the rat. Materials and methods: Temporary middle cerebral artery occlusion was performed on seven Sprague–Dawley rats. After 60min of occlusion and 90min of reperfusion MRI was performed including DWI, dynamic susceptibility contrast-weighted MR imaging (DSC-MRI) and qT2′. ROIs were placed inside the DWI lesion and transferred to rCBF- and qT2′-maps. rCBF and qT2′ were compared to corresponding tissue in the contralateral hemisphere. Results: qT2′ was lower in the infarcted areas when compared to the contralateral hemisphere. Correlation between rCBF and qT2′ was r =0.41, p =0.14 (Pearson''s correlation coefficient), when corrected for outliers it was r =0.58, p =0.04. Conclusion: Our results show that there is a moderate correlation between rCBF and qT2′. qT2′-maps could be used to explore cerebral perfusion without the application of contrast agent or radiation. [Copyright &y& Elsevier]

Published
2009
Full Text
View/download PDF

45. Neurologic injury in cardiac surgery: aortic atherosclerosis emerges as the single most important risk factor.

Author

Vaage, Jarle, Jensen, Ulf, Ericsson, Anders, Vaage, J, Jensen, U, and Ericsson, A

Subjects
*ATHEROEMBOLISM, CARDIAC surgery risk factors
Abstract

With older and sicker patients undergoing cardiac surgery, neurologic injury has emerged as an increasingly important cause of rising costs, morbidity and mortality. Several studies investigating the relationship between atherosclerotic aortic disease and subsequent adverse clinical outcomes have demonstrated that the single most important risk factor for neurologic injury following cardiac surgery is the presence of aortic atheromatous disease. The results of these studies suggest that atheroemboli are correlated with neurologic injury following cardiac surgery. Surgical techniques to avoid and prevent particulate debris during cardiac surgery may be a major step in preventing severe neurologic injury. [ABSTRACT FROM AUTHOR]

Published
2000
Full Text
View/download PDF

46. Rapid Endovascular Catheter Core Cooling Combined With Cold Saline as an Adjunct to Percutaneous Coronary Intervention for the Treatment of Acute Myocardial Infarction The CHILL-MI Trial: A Randomized Controlled Study of the Use of Central Venous Catheter Core Cooling Combined With Cold Saline as an Adjunct to Percutaneous Coronary Intervention for the Treatment of Acute Myocardial Infarction

Author

Erlinge, David, Götberg, Matthias, Lang, Irene, Holzer, Michael, Noc, Marko, Clemmensen, Peter, Jensen, Ulf, Metzler, Bernhard, James, Stefan, Bötker, Hans Erik, Omerovic, Elmir, Engblom, Henrik, Carlsson, Marcus, Arheden, Håkan, Östlund, Ollie, Wallentin, Lars, Harnek, Jan, and Olivecrona, Göran K.

Subjects
STEMI, cardioprotection, hypothermia
Abstract

ObjectivesThe aim of this study was to confirm the cardioprotective effects of hypothermia using a combination of cold saline and endovascular cooling.BackgroundHypothermia has been reported to reduce infarct size (IS) in patients with ST-segment elevation myocardial infarctions.MethodsIn a multicenter study, 120 patients with ST-segment elevation myocardial infarctions (

Full Text
View/download PDF

47. Percutaneous Coronary Intervention for Vulnerable Coronary Atherosclerotic Plaque.

Author

Stone, Gregg W., Maehara, Akiko, Ali, Ziad A., Held, Claes, Matsumura, Mitsuaki, Kjøller-Hansen, Lars, Bøtker, Hans Erik, Maeng, Michael, Engstrøm, Thomas, Wiseth, Rune, Persson, Jonas, Trovik, Thor, Jensen, Ulf, James, Stefan K., Mintz, Gary S., Dressler, Ovidiu, Crowley, Aaron, Ben-Yehuda, Ori, Erlinge, David, and PROSPECT ABSORB Investigators

Subjects
*ATHEROSCLEROTIC plaque, *PERCUTANEOUS coronary intervention, *INTRAVASCULAR ultrasonography, *BIOABSORBABLE implants, *ANGINA pectoris, *ACUTE coronary syndrome, *CORONARY disease, *PILOT projects, *RESEARCH, *ULTRASONIC imaging, *CORONARY artery stenosis, *RESEARCH methodology, *MEDICAL care, *SURGICAL stents, *EVALUATION research, *MEDICAL cooperation, *ATHEROSCLEROSIS, *CARDIOVASCULAR system, *BLOOD vessel prosthesis, *COMPARATIVE studies, *RANDOMIZED controlled trials, *CORONARY artery disease
Abstract

Background: Acute coronary syndromes most commonly arise from thrombosis of lipid-rich coronary atheromas that have large plaque burden despite angiographically appearing mild.Objectives: This study sought to examine the outcomes of percutaneous coronary intervention (PCI) of non-flow-limiting vulnerable plaques.Methods: Three-vessel imaging was performed with a combination intravascular ultrasound (IVUS) and near-infrared spectroscopy (NIRS) catheter after successful PCI of all flow-limiting coronary lesions in 898 patients presenting with myocardial infarction (MI). Patients with an angiographically nonobstructive stenosis not intended for PCI but with IVUS plaque burden of ≥65% were randomized to treatment of the lesion with a bioresorbable vascular scaffold (BVS) plus guideline-directed medical therapy (GDMT) versus GDMT alone. The primary powered effectiveness endpoint was the IVUS-derived minimum lumen area (MLA) at protocol-driven 25-month follow-up. The primary (nonpowered) safety endpoint was randomized target lesion failure (cardiac death, target vessel-related MI, or clinically driven target lesion revascularization) at 24 months. The secondary (nonpowered) clinical effectiveness endpoint was randomized lesion-related major adverse cardiac events (cardiac death, MI, unstable angina, or progressive angina) at latest follow-up.Results: A total of 182 patients were randomized (93 BVS, 89 GDMT alone) at 15 centers. The median angiographic diameter stenosis of the randomized lesions was 41.6%; by near-infrared spectroscopy-IVUS, the median plaque burden was 73.7%, the median MLA was 2.9 mm2, and the median maximum lipid plaque content was 33.4%. Angiographic follow-up at 25 months was completed in 167 patients (91.8%), and the median clinical follow-up was 4.1 years. The follow-up MLA in BVS-treated lesions was 6.9 ± 2.6 mm2 compared with 3.0 ± 1.0 mm2 in GDMT alone-treated lesions (least square means difference: 3.9 mm2; 95% confidence interval: 3.3 to 4.5; p < 0.0001). Target lesion failure at 24 months occurred in similar rates of BVS-treated and GDMT alone-treated patients (4.3% vs. 4.5%; p = 0.96). Randomized lesion-related major adverse cardiac events occurred in 4.3% of BVS-treated patients versus 10.7% of GDMT alone-treated patients (odds ratio: 0.38; 95% confidence interval: 0.11 to 1.28; p = 0.12).Conclusions: PCI of angiographically mild lesions with large plaque burden was safe, substantially enlarged the follow-up MLA, and was associated with favorable long-term clinical outcomes, warranting the performance of an adequately powered randomized trial. (PROSPECT ABSORB [Providing Regional Observations to Study Predictors of Events in the Coronary Tree II Combined with a Randomized, Controlled, Intervention Trial]; NCT02171065). [ABSTRACT FROM AUTHOR]

Published
2020
Full Text
View/download PDF

48. Stent thrombosis in new-generation drug-eluting stents in patients with STEMI undergoing primary PCI: a report from SCAAR.

Author

Sarno, Giovanna, Lagerqvist, Bo, Nilsson, Johan, Frobert, Ole, Hambraeus, Kristina, Varenhorst, Christoph, Jensen, Ulf J, Tödt, Tim, Götberg, Matthias, and James, Stefan K

Abstract

Background: Some concerns still have not been resolved about the long-term safety of drug-eluting stents (DES) in patients with acute STEMI. Objectives: The aim of this study was to evaluate the stent thrombosis (ST) rate up to 3 years in patients with ST-segment elevation myocardial infarction (STEMI) treated by primary percutaneous coronary intervention (PCI) with new-generation drug-eluting stents (n-DES) compared with bare-metal stents (BMS) and old-generation drug-eluting stents (o-DES) enrolled in the SCAAR (Swedish Coronary Angiography and Angioplasty Registry). Methods: From January 2007 to January 2013, 34,147 patients with STEMI were treated by PCI with n-DES (n = 4,811), o-DES (n = 4,271), or BMS (n = 25,065). The risks of early/late (up to 1 year) and very late definite ST (after 1 year) were estimated. Results: Cox regression landmark analysis showed a significantly lower risk of early/late ST in patients treated with n-DES (hazard ratio [HR]: 0.65; 95% confidence interval [CI]: 0.43 to 0.99; p = 0.04) and o-DES (HR: 0.60; 95% CI: 0.41 to 0.89; p = 0.01) compared with the BMS group. The risk of very late ST was similar between the n-DES and BMS groups (HR: 1.52; 95% CI: 0.78 to 2.98; p = 0.21), whereas a higher risk of very late ST was observed with o-DES compared with BMS (HR: 2.88; 95% CI: 1.70 to 4.89; p < 0.01). Conclusions: Patients treated with n-DES have a lower risk of early/late ST than patients treated with BMS. The risk of very late ST is low and comparable between n-DES and BMS up to 3 years of follow-up, whereas o-DES treatment is associated with an increased risk of very late ST. The current STEMI guidelines might require an update in light of the results of this and other recent studies. [ABSTRACT FROM AUTHOR]

Published
2014
Full Text
View/download PDF

49. Rapid Endovascular Catheter Core Cooling Combined With Cold Saline as an Adjunct to Percutaneous Coronary Intervention for the Treatment of Acute Myocardial Infarction: The CHILL-MI Trial: A Randomized Controlled Study of the Use of Central Venous Catheter Core Cooling Combined With Cold Saline as an Adjunct to Percutaneous Coronary Intervention for the Treatment of Acute Myocardial Infarction.

Author

Erlinge, David, Götberg, Matthias, Lang, Irene, Holzer, Michael, Noc, Marko, Clemmensen, Peter, Jensen, Ulf, Metzler, Bernhard, James, Stefan, Bötker, Hans Erik, Omerovic, Elmir, Engblom, Henrik, Carlsson, Marcus, Arheden, Håkan, Östlund, Ollie, Wallentin, Lars, Harnek, Jan, and Olivecrona, Göran K.

Subjects
*ENDOVASCULAR surgery, *HYPOTHERMIA, *MYOCARDIAL infarction treatment, *CORONARY angiography, *SALINE solutions, *RANDOMIZED controlled trials, *INFUSION therapy
Abstract

Objectives: The aim of this study was to confirm the cardioprotective effects of hypothermia using a combination of cold saline and endovascular cooling. Background: Hypothermia has been reported to reduce infarct size (IS) in patients with ST-segment elevation myocardial infarctions. Methods: In a multicenter study, 120 patients with ST-segment elevation myocardial infarctions (<6 h) scheduled to undergo percutaneous coronary intervention were randomized to hypothermia induced by the rapid infusion of 600 to 2,000 ml cold saline and endovascular cooling or standard of care. Hypothermia was initiated before percutaneous coronary intervention and continued for 1 h after reperfusion. The primary end point was IS as a percent of myocardium at risk (MaR), assessed by cardiac magnetic resonance imaging at 4 ± 2 days. Results: Mean times from symptom onset to randomization were 129 ± 56 min in patients receiving hypothermia and 132 ± 64 min in controls. Patients randomized to hypothermia achieved a core body temperature of 34.7°C before reperfusion, with a 9-min longer door-to-balloon time. Median IS/MaR was not significantly reduced (hypothermia: 40.5% [interquartile range: 29.3% to 57.8%; control: 46.6% [interquartile range: 37.8% to 63.4%]; relative reduction 13%; p = 0.15). The incidence of heart failure was lower with hypothermia at 45 ± 15 days (3% vs. 14%, p < 0.05), with no mortality. Exploratory analysis of early anterior infarctions (0 to 4 h) found a reduction in IS/MaR of 33% (p < 0.05) and an absolute reduction of IS/left ventricular volume of 6.2% (p = 0.15). Conclusions: Hypothermia induced by cold saline and endovascular cooling was feasible and safe, and it rapidly reduced core temperature with minor reperfusion delay. The primary end point of IS/MaR was not significantly reduced. Lower incidence of heart failure and a possible effect in patients with early anterior ST-segment elevation myocardial infarctions need confirmation. (Efficacy of Endovascular Catheter Cooling Combined With Cold Saline for the Treatment of Acute Myocardial Infarction [CHILL-MI]; NCT01379261) [ABSTRACT FROM AUTHOR]

Published
2014
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results