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39 results on '"Javierre G"'

2. 2246P Tumor-infiltrating lymphocites and gene expression across multiple cancer-types: A translational analysis from the SOLTI-1904-ACROPOLI study

Author

Solis, E. Segui, Torres, E. Sanfeliu, Gonzalez-Farre, B., Pascual, T., Brasó-Maristany, F., Galván, P., Farre, X. González, Salvador, F., Felip, E., Garralda, E., Paz-Ares, L., Juan, M., Nin, R. Mesia, Fernandez, A.M. Arance, Cervantes, A., Martin-Liberal, J., Javierre, G. Villacampa, Tabernero, J., and Prat, A.

Published
2023
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3. 473P Predictive factors for drug-induced liver injury in patients with ER-positive HER2-negative metastatic breast cancer treated with first-line cyclin-dependent kinase 4/6 inhibitors

Author

Cano, K.S. Vega, Javierre, G. Villacampa, Baselga, P. Mascaró, Mirallas, O., Adelantado, E. Zamora, Gomez, L. Sanz, Ortiz, C., Lapena, M. Cruellas, Arumi de Dios, M., Puy, M. Borrell, Filippi-Arriaga, F., Joval, L., Yaringaño, J.G., Martínez-Albaladejo, P., Buch, P.B., Esteban, P., Ruiz-Ortega, L., Manich, C. Saura, Riveiro-Barciela, M., and Ezquerra, M. Bellet

Published
2023
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4. 150P Validation of a genomic assay in early-stage HER2+ breast cancer (BC) treated with trastuzumab and pertuzumab (HP): A correlative analysis from PHERGain phase II trial

Author

Llombart Cussac, A., Pérez-García, J.M., Pare Brunet, L., Villacampa Javierre, G., Brasó-Maristany, F., Gion Cortes, M., Schmid, P., Colleoni, M.A., Ruiz Borrego, M., Galván, P., Parker, J., Perou, C.M., Villagrasa Gonzalez, P., Guerrero, J.A., Sampayo-Cordero, M., Mancino, M., Prat, A., and Cortés, J.

Published
2023
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6. 595P The DUREC trial: Durvalumab plus total neoadjuvant therapy in locally advanced rectal cancer - a multicenter, single-arm, phase II study (GEMCAD-1703)

Author

Capdevila Castillon, J., Alonso, V., Macias Declara, I., Melian, M., Gallego Plazas, J., Vera, R., Riesco Martinez, M.C., Maurel, J., Grana Suarez, B., Hernando, J., Garcia Alvarez, A., Navalpotro, B., Soler Gonzalez, G., Polo, E., Garcia Fadrique, A., Espin, E., Fernandez Martos, C., Villacampa Javierre, G., and Losa, F.

Published
2023
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7. 272TiP HARMONIA SOLTI-2101 / AFT-58: A head-to-head phase III study comparing ribociclib (RIB) and palbociclib (PAL) in patients (pts) with hormone receptor-positive/HER2-negative/HER2-enriched (HR+/HER2-/HER2-E) advanced breast cancer (ABC)

Author

Pascual, T., Stover, D.G., Thuerigen, A., Perou, C.M., Ciruelos, E.M., Casas Fernandez Tejerina, A., Spears, P., Roux, E., Hu, H., Lu, Y-S., Tolaney, S.M., Partridge, A., Villacampa Javierre, G., Ferrero Cafiero, J.M., Carey, L., and Prat, A.

Published
2022
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9. 202TiP SOLTI-1805 TOT-HER3 trial: A window-of-opportunity trial of patritumab deruxtecan (HER3-DXd) in patients with treatment-naïve, early breast cancer

Author

Oliveira, M., Cejalvo Andujar, J.M., Margeli Vila, M., Tolosa Ortega, P., Martinez Saez, O., Salvador Bofill, F.J., Cruz Jurado, J., Luna Barrera, A.M., Arumi de Dios, M.A., Vidal Losada, M.J., Guerra, J.A., Pernas Simon, S., Villacampa Javierre, G., Gonzalez-farre, B., Sanfeliu Torres, E., Santhanagopal, A., Falato, C., Ferrero Cafiero, J.M., Pascual, T., and Prat, A.

Published
2022
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12. 1724P Prognostic parameters at admission as predictors of hospital length of stay (HLOS) and overall survival (OS) in hospitalized oncologic patients (pts) of a tertiary hospital

Author

Mirallas, O., López-Valbuena, D., Javierre, G. Villacampa, Vega, K.S., Gómez-Puerto, D., Salva-Torres, C., Rezqallah, A., Molina, G., Aguilar-Company, J., Roca, M., Andurell, L., Palmas, F., Fernandez, M.E. Elez, Alonso, A., Gomez-Pardo, P., Serradell, S., Tabernero, J., Felip, E., Peñuelas, A., and Carles, J.

Published
2021
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13. 1431P Descriptive analysis and prognostic factors of microsatellite instability (MSI) gastric cancer patients (pts) compared to microsatellite stable (MSS) pts in a tertiary hospital

Author

Mirallas, O., López-Valbuena, D., García-Illescas, D., Martin Cullell, B., Rodriguez, N., Gantxegi, A., Marmolejo Castaneda, D.H., Valdivia, A.A., Rezqallah Aron, M.A., Villacampa Javierre, G., Gómez-Puerto, D., Vega, K.S., Molina, G., Salva-Torres, C., Jofre, M., Alsina, M., Castro, S., Tabernero, J., Diez, M., and Macarulla Mercade, T.

Published
2021
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16. 426P Spotlight on refractory metastatic colorectal cancer (refMCRC): Role of prognostic characteristics in the continuum of care

Author

Valdivia, A.A., Salva, F., Ros, J., Baraibar, I., Argiles Martinez, G., Saoudi Gonzalez, N., Garcia, A., Mulet Margalef, N., Cuadra Urteaga, J.L., Capdevila, J., Salud Salvia, M.A., Paez, D., Casado, E., Comas, R., Ruiz-Pace, F., Villacampa Javierre, G., Acosta Eyzaguirre, D.A., Dienstmann, R., Elez Fernandez, M.E., and Tabernero, J.

Published
2021
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20. 1545P DNA damage repair (DDR) gene mutations (mut) are predictors of response to platinum-based chemotherapy in advanced pancreatic cancer (PC) patients (pts)

Author

Verdaguer, H., Guardiola, M., Mancuso, F.M., Acosta Eyzaguirre, D.A., Buxò, E., Hernando, J., Diez Garcia, M., Laquente, B., Baraibar Argota, I., Ros Montañá, F.J., Garcia-Alvarez, A., Matito, J., Martin, A., Sierra, A., Villacampa Javierre, G., Molero, C., Miquel, J.M., Vivancos, A., Dienstmann, R., and Macarulla Mercadé, T.

Published
2020
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23. 1858P Role of depression and quality of life (QOL) status as predictors of hospital length of stay (HLOS) and overall survival (OS) in hospitalized oncologic patients (pts)

Author

Mirallas, O., López Valbuena, D.E., Rezqallah Aron, M.A., Molina, G., Vega, S., Gómez-Puerto, D., Villacampa Javierre, G., Andurell, L., Palmas, F., Burgos, R., Rodriguez, K., Moreno, I., Delgado Heredia, M.J., Roca, M., Dienstmann, R., Alonso, A., Serradell, S., and Carles, J.

Published
2020
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24. 1154TiP A randomized, prospective, multicenter study to assess the impact of early detection of asymptomatic brain metastases (mets) vs standard follow-up on symptomatic brain mets free survival (SBMFS) in pts with previously untreated, unresectable or metastatic melanoma (MM)

Author

Couselo, E. Munoz, Velez, C. Ortiz, Dienstmann, R., Javierre, G. Villacampa, Carboneras, M., Muñoz, S., Batista, M., Gonzalez, M., Auger, C., Rovira, A., and Martinez-Ricarte, F.

Published
2020
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26. 1068P Rescue chemotherapy (CT) after immune-oncology (IO) drugs in patients (pts) with refractory solid tumours: A propensity score (PS) matched cohort study

Author

Galvão, V., Montañá, F.J. Ros, Matos, I., Viaplana, C., Javierre, G. Villacampa, Braña, I., Pedrazzoli, A.B. Azaro, Villar, M. Vieito, Santa Gadea, O. Saavedra, Casal, G. Alonso, Hernando-Calvo, A., Carles, J., Mercade, T. Macarulla, Couselo, E. Munoz, Elez, E., Felip, E., Tabernero, J., Dienstmann, R., Oliveira, M., and Garralda, E.

Published
2020
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27. 938P Nutritional status (NS) as a strong predictor for immunotherapy (IT) outcome in recurrent or metastatic (R/M) head and neck squamous cell carcinoma (HNSCC) patients (pts)

Author

Hernando-Calvo, A., Mirallas, O., Marmolejo Castaneda, D.H., Vieito, M., Saavedra Santa Gadea, O., Gardeazabal, I., Villacampa Javierre, G., Aguilar, S., Martin Liberal, J., Bescós, C., Lorente, J., Giralt, J., Benavente, S., Fuentes, J.F., Temprana-Salvador, J., Alberola, M., Dienstmann, R., Garralda, E., Felip, E., and Braña, I.

Published
2020
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28. 880TiP Randomized, open-label, phase II trial of dostarlimab (TSR-042), as maintenance therapy for patients with high-risk locally advanced cervical cancer after chemo-radiation: ATOMICC study

Author

Oaknin, A., Iglesias, M., Alarcon, J.D., Villacampa Javierre, G., Garcia, L. Gaba, Santaballa, A., Manso, L.M., Romero, I., Barretina Ginesta, M.P., Churruca, C., García, Y., Sanchez, A.B., Marquina, G., Pardo, B., Redondo, A., Rubio, M.J., and González Martín, A.

Published
2020
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29. Structures of Plutonium(IV) and Uranium(VI) with N,N‑Dialkyl Amides from Crystallography, X‑ray Absorption Spectra, and Theoretical Calculations

Author

Acher, E., Cherkaski, Y. H., Dumas, T., Tamin, C., Guillaumont, D., Boubals, N., Javierre, G., Hennig, C., Solari, P. L., and Charbonnel, M.-C.

Subjects
EXAFS, XRD, U(VI), Pu(IV), DFT
Abstract

The structures of plutonium(IV) and uranium(VI) ions with a series of N,N-dialkyl amides ligands with linear and branched alkyl chains were elucidated from single-crystal X-ray diffraction (XRD), extended X-ray absorption fine structure (EXAFS), and theoretical calculations. In the field of nuclear fuel reprocessing, N,N-dialkyl amides are alternative organic ligands to achieve the separation of uranium(VI) and plutonium(IV) from highly concentrated nitric acid solution. EXAFS analysis combined with XRD shows that the coordination structure of U(VI) is identical in the solution and in the solid state and is independent of the alkyl chain: two amide ligands and four bidentate nitrate ions coordinate the uranyl ion. With linear alkyl chain amides, Pu(IV) also adopt identical structures in the solid state and in solution with two amides and four bidentate nitrate ions. With branched alkyl chain amides, the coordination structure of Pu(IV) was more difficult to establish unambiguously from EXAFS. Density functional theory (DFT) calculations were consequently performed on a series of structures with different coordination modes. Structural parameters and Debye−Waller factors derived from the DFT calculations were used to compute EXAFS spectra without using fitting parameters. By using this methodology, it was possible to show that the branched alkyl chain amides form partly outer-sphere complexes with protonated ligands hydrogen bonded to nitrate ions.

Published
2016

37. Atropisomerism in a 10-Membered Ring with Multiple Chirality Axes: (3 Z,9 Z)-1,2,5,8-Dithiadiazecine-6,7(5 H,8 H)-dione Series.

Author

Risso V, Farran D, Javierre G, Naubron JV, Giorgi M, Piras P, Jean M, Vanthuyne N, Fruttero R, Lorcy D, and Roussel C

Abstract

For the first time, chirality in (3 Z,9 Z)-1,2,5,8-dithiadiazecine-6,7(5 H,8 H)-dione series was recognized. Enantiomers of the 4,9-dimethyl-5,8-diphenyl analogue were isolated at room temperature, and their thermal stability was determined. X-ray crystallography confirmed the occurrence of a pair of enantiomers in the crystal. Absolute configurations were assigned by comparing experimental and calculated vibrational/electronic circular dichroism spectra of isolated enantiomers. A distorted tesseract (four-dimensional hypercube) was used to visualize the calculated enantiomerization process, which requires the rotation around four chirality axes. Conformers of higher energy as well as several concurrent pathways of similar energies were revealed.

Published
2018
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38. Racemization and transesterification of alkyl hydrogeno-phenylphosphinates.

Author

Javierre G, Fortrie R, Jean M, Moraleda D, Naubron JV, and Fotiadu F

Abstract

In this article, we explore, both theoretically and experimentally, the general reactivity of alkyl hydrogeno-phenylphosphinates with alcohols. We show that alcohol molecules act exclusively as nucleophilic species, and add to alkyl hydrogeno-phenylphosphinates, leading to pentacoordinated intermediates. These intermediates are shown to subsequently competitively undergo alcohol eliminations and/or Berry pseudorotations. This offers several possible routes for racemizations and/or alcohol exchange reactions. Transition standard Gibbs free energies predicted from DFT calculations for the overall alcohol exchange mechanism are shown to be compatible with those experimentally measured in case ethanol reacts with ethyl hydrogeno-phenylphosphinate (134.5∼136.0 kJ mol -1 at 78 °C). Graphical abstract ᅟ.

Published
2017
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39. Structures of Plutonium(IV) and Uranium(VI) with N,N-Dialkyl Amides from Crystallography, X-ray Absorption Spectra, and Theoretical Calculations.

Author

Acher E, Hacene Cherkaski Y, Dumas T, Tamain C, Guillaumont D, Boubals N, Javierre G, Hennig C, Solari PL, and Charbonnel MC

Abstract

The structures of plutonium(IV) and uranium(VI) ions with a series of N,N-dialkyl amides ligands with linear and branched alkyl chains were elucidated from single-crystal X-ray diffraction (XRD), extended X-ray absorption fine structure (EXAFS), and theoretical calculations. In the field of nuclear fuel reprocessing, N,N-dialkyl amides are alternative organic ligands to achieve the separation of uranium(VI) and plutonium(IV) from highly concentrated nitric acid solution. EXAFS analysis combined with XRD shows that the coordination structure of U(VI) is identical in the solution and in the solid state and is independent of the alkyl chain: two amide ligands and four bidentate nitrate ions coordinate the uranyl ion. With linear alkyl chain amides, Pu(IV) also adopt identical structures in the solid state and in solution with two amides and four bidentate nitrate ions. With branched alkyl chain amides, the coordination structure of Pu(IV) was more difficult to establish unambiguously from EXAFS. Density functional theory (DFT) calculations were consequently performed on a series of structures with different coordination modes. Structural parameters and Debye-Waller factors derived from the DFT calculations were used to compute EXAFS spectra without using fitting parameters. By using this methodology, it was possible to show that the branched alkyl chain amides form partly outer-sphere complexes with protonated ligands hydrogen bonded to nitrate ions.

Published
2016
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