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The policies related to COVID‐19 pandemic such as stay at home orders and social distancing increased daily stress and associated impairments in mental health. This study examines the association between COVID‐related stress and cognitive functioning by examining two different types of daily memory lapses, those related to prospective memory (i.e., memory for future plans) and retrospective memory (i.e., memory for past information) as well as the perceived emotional and functional consequences of daily memory problems. As part of a larger study, 58 adults (18 men; 22 ± 3 years) completed a web‐based version of the daily inventory of stressful events including stress related to COVID‐19 and positive/negative affect for eight consecutive days between 8 September 2020 and 11 November 2020. Findings showed that prospective lapses were positively correlated with COVID‐19 stressors (r = 0.41, p = 0.002). At the within‐person level, daily COVID‐19 stressors were significantly associated with the number of prospective lapses (b = 0.088, SE = 0.040). COVID‐19‐related stressors were not significantly related to retrospective lapses (all ps > 0.05). Our findings suggested that more daily COVID‐19 stressors were related to greater numbers of prospective lapses in daily life even among healthy younger adults. Thus, future research should address long term relations of COVID‐19 stress and cognitive functioning in addition to the specific cognitive impairments related to COVID‐19 infection. [ABSTRACT FROM AUTHOR]

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Objectives: The present study aims to identify distinct types of relationships between grandparents and their adult children, measure the associations between these relationship types and depressive symptoms among grandparents, and determine whether these associations vary by grandparent status. Method: This study uses data from a sample of 1,196 grandparents age 51 and older from the 2014 Health and Retirement Study. Latent class analysis (LCA) is applied and identifies types of grandparent–adult children relationships. Ordinary Least Squares (OLS) regression models are used to estimate the association between relationship types and depressive symptoms by grandparent status. Results: LCA identified four grandparent-adult children relationship types: amicable, ambivalent, detached, and disharmonious. Custodial and co-parenting grandparents were most likely to report having an ambivalent relationship with their adult children. Among co-parenting and custodial grandparents, disharmonious relationships were associated with more depressive symptoms. Conclusion: Interventions are suggested to improve emotional relationships with adult children and dyadic family relationships among grandparent families. [ABSTRACT FROM AUTHOR]

Guided by a convoy model of social relations, this study explores the complex relationships between loneliness, age at immigration, familial relationships, and depressive symptoms among older immigrants. This study used 2010 Health and Retirement Study data from a sample of 575 immigrants (52% female, age range 65–99 years). Ordinary least squares regression models were estimated. The findings indicate that for older immigrants who came to the United States at age 45 or older, loneliness was significantly positively associated with depressive symptoms. Further, perceived negative strain and hours spent helping family moderated this relationship such that the effect of loneliness on depressive symptoms was stronger among respondents who perceived more negative family strain and spent fewer hours helping family. Familial relationships are crucial for the psychological well-being of older immigrants because they can be a source of either stress or support. The results have implications for how research and practices can support the immigrant families. [ABSTRACT FROM AUTHOR]

This study examined the longitudinal association of depressive symptoms with grandchild care intensity and whether the association varies by household structure, residential area, and gender for Chinese grandparents. Using data from three waves of the China Health and Retirement Longitudinal Study (CHARLS, 2011–2015), we applied multilevel mixed effects models to examine changes in depressive symptoms and the associations with caregiving intensity and to test the moderation effects of residence, living arrangement, and gender. After controlling for sociodemographic and health covariates, we found that providing a medium level of grandchild care was associated with fewer baseline depressive symptoms compared with non-caregivers. Providing low-level care among those living with spouse/partner and among those living with child(ren)/others was associated with fewer depressive symptoms relative to non-caregivers with similar living arrangements. Findings indicate that a medium level of involvement in childcare was associated with better mental wellness and low levels of caregiving may benefit nonresidential caregivers. More prospective longitudinal studies are needed to improve the operationalization of grandparent caregiving, validate the associated health outcomes, and apply a contextual approach to examine socioeconomic, cultural, and policy-related contexts of caregiving in the changing world of China. [ABSTRACT FROM AUTHOR]

Guided by a convoy model of social relations, this study investigates the relationships between grandparenting status, social relations, and mortality among community-dwelling grandparents age 65 and older who are caring for their grandchildren. The data were drawn from the 2008 and 2016 waves of the Health and Retirement Study (N = 564). Latent class analysis was used to identify the social network structure based on six indicators of interpersonal relationships and activities. A series of hierarchical Weibull hazard models estimated the associations between grandparent caregiving, social relations, and mortality risk. Results of survival analyses indicate that co-parenting and custodial grandparents had higher all-cause mortality risk than grandparents who babysat occasionally; however, for custodial grandparents, the association was not significant once social relation variables were added to the model. This study suggests that community-based support may be beneficial to older grandparents and improved relationship quality is integral to the well-being of older adults. [ABSTRACT FROM AUTHOR]

Objectives For the growing population of older immigrants in the United States, both age at immigration and familial relationships are important factors affecting psychological well-being. This study explores how age at immigration and contemporary relationships with adult children combine to explain older immigrants' depressive symptoms. Method This study uses 2014 Health and Retirement Study data from a sample of 759 immigrants aged 65 and older who have at least one adult child aged 21 or older. A series of ordinary least squares regressions and mediational analyses were conducted. Results Findings indicate that structural solidarity significantly mediates the association between age at immigration and depressive symptoms. Specifically, immigrating in later life was associated with a lower level of depressive symptoms through its relationship with structural solidarity. In addition, giving monetary support to children and providing care for grandchildren may alleviate depressive symptoms for older immigrants. Discussion This study suggests that relationships with adult children may differ with age at immigration. The types of support that older immigrants provide to their adult children may be crucial because such support may instill a sense of obligation and reciprocity that may be beneficial to the psychological well-being of older immigrants. [ABSTRACT FROM AUTHOR]

A major challenge facing an aging society is the increased caregiving needs among community-dwelling older adults with chronic conditions. Reliance on social relations may help address caregiving needs and maintain older adults' mental well-being. This study examines the roles of different aspects of social relations—social network size, social support, and service use—in the association between caregiving needs and mental health status (MHS). Using a sample of adults age 55 and over in an urban setting, authors tested the direct, mediation, and moderation effects models of social relations. Structural equation modeling was applied and latent variables of caregiving needs, MHS, and social network size were identified. Results showed that caregiving needs and informal social support (that is, network size, positive support, and negative strain) were directly related to MHS and that informal social support partially mediated the negative effect of caregiving needs on MHS; by contrast, service use moderated the association, indicating that those with caregiving needs who used more services were in better MHS than their counterparts with less service use. Findings point to the importance of social work interventions aimed at improving social relations and enhancing awareness and access to social services. [ABSTRACT FROM AUTHOR]

This study aims to assess racial differences in subjective wellbeing (SWB) and to examine whether the pathways of social support and social engagement to SWB vary by racial groups in the United States of America. Using a local sample (N = 1,035) and a nationally representative sample of the Health and Retirement Study (N = 7,718), we compared life satisfaction and happiness between non-Hispanic Whites and Blacks aged 55 and over. We evaluated the extent to which race, other socio-demographic characteristics, health, social engagement and social support explained the variances in SWB and examined the moderation effects of race on the relationships of SWB with age, social support and social engagement. Multiple regression analyses showed that non-Hispanic Blacks were at least as satisfied as, and even happier than White peers, after equalising social resources and health variables. Social support was significantly related to SWB, and it seemed that positive support was more important to Whites than to Blacks in predicting life satisfaction. In addition, the racial crossover effect existed, that is, the old-old (80+) Blacks were happier than their White peers. Findings indicate a national trend of the race paradox in SWB and underscore the importance of social support in promoting older adults' wellbeing. Future research is recommended to investigate other potential mechanisms among Black older Americans to explain their relatively better SWB. [ABSTRACT FROM AUTHOR]

This study aims to examine the effect of the death of a family member or friend on psychological well-being, specifically the moderating effects of first-time volunteering and social network. With the sample of 354 volunteers from the Experience Corps® (EC) programs, Analysis of covariance (ANCOVA) estimated the differences in psychological well-being. Among volunteers who had experienced the death of a family member or friend, new volunteers showed significant improvement in positive affect compared to experienced volunteers. EC members gained additional social contacts through volunteering. Formal volunteering has a salutatory effect on older adults' health after the loss of family members. [ABSTRACT FROM AUTHOR]

Guided by a stress-buffering model, this study examined the effect of the caregiver stress on depressive symptoms, specifically the moderating effects of social support and volunteering on the relationship between stress and depressive symptoms among grandparent caregivers. The 2010 Health and Retirement Survey included a sample of 1,973 grandparent caregivers who reported their stress scores. Findings suggest that positive social support and volunteering significantly moderated the relationship between stress and depressive symptoms. In particular, the study revealed that perceived quality of relations may help grandparent caregivers cope with their ongoing stress and enlarged social interaction may buffer the increase of negative stressor outcomes. [ABSTRACT FROM AUTHOR]

Caring for an older adult with memory loss is stressful. Caregiver stress could produce negative outcomes such as depression. Previous research is limited in examining multiple intermediate pathways from caregiver stress to depressive symptoms. This study addresses this limitation by examining the role of self-efficacy, social support, and problem solving in mediating the relationships between caregiver stressors and depressive symptoms. Using a sample of 91 family caregivers, we tested simultaneously multiple mediators between caregiver stressors and depression. Results indicate that self-efficacy mediated the pathway from daily hassles to depression. Findings point to the importance of improving self-efficacy in psychosocial interventions for caregivers of older adults with memory loss. [ABSTRACT FROM AUTHOR]

The World Health Organization recently highlighted the serious worldwide problem of the emergence of antibiotic-resistant or antibiotic multidrug-resistant bacteria. Carbapenem-resistant Enterobacterales, including carbapenemase-producing Enterobacterales (CPE), are major antibiotic-resistant bacteria that can be identified by various methods, including antibiotic susceptibility testing, PCR, and immunologic assays. However, there is a need for a faster, more accurate, low-cost, and easy method to detect CPE strains. We previously developed an osmotic shock matrix-assisted laser desorption/ionization mass spectrometry (OS-MALDI MS) method for directly detecting intact Klebsiella pneumoniae carbapenemase (KPC) using osmotic shock cell lysis. In this study, we evaluated the OS-MALDI MS method and compared it with two other methods (octyl-glucoside-aided direct KPC detection method [OG-MALDI MS] and Bruker's MBT subtyping module indirect method [MBT-SM MALDI MS]). We first completed an analytical performance evaluation of the OS-MALDI MS method according to Clinical and Laboratory Standards Institute guidelines. Clinical testing was performed with 437 clinical isolates, including 292 KPC-producing bacteria and 145 non-KPC-producing bacteria. The OS-MALDI MS method exhibited 95.9% sensitivity, 100.0% specificity, and 100.0% precision for detecting KPC. Accuracy of the OS-MALDI MS, OG-MALDI MS, and MBT-SM MALDI MS methods was 97.3%, 55.9%, and 50.2%, respectively. In conclusion, the OS-MALDI MS method clearly outperformed the other methods, exhibiting the highest accuracy and sensitivity of the three methods. We propose the OS-MALDI MS method as a practical, useful method for clinic environments, which may help guide appropriate antibiotic treatment and contribute to the prevention of the spread of CPE.

Purpose: Clinical mass spectrometry requires a simple step process for sample preparation. This study aims to optimize the method for isolating periplasmic protein from Gram-negative bacteria and apply to clinical mass spectrometry., Experimental Design: The Klebsiella pneumoniae carbapenemase (KPC)-producing E. coli standard cells were used for optimizing the osmotic shock (OS) lysis method. The supernatant from OS lysis was analysed by LC-MS/MS and MALDI-TOF MS. The effectiveness of the OS lysis method for KPC-2-producing Enterobacteriaceae clinical isolates were then confirmed by MALDI-TOF MS., Results: The optimized OS lysis using KPC-2 producing E. coli standard cells showed a high yield of KPC-2 protein and enriches periplasmic proteins. Compared with other lysis methods, the detection sensitivity of KPC-2 protein significantly increased in MALDI-TOF MS analysis. Nineteen clinical isolates were validated by MALDI-TOF MS using the OS method, which also showed higher detection sensitivity compared to other lysis method (e.g., 1.5% n-octyl-β-D-glucopyranoside) (p < 0.001)., Conclusions and Clinical Relevance: This study provides a straightforward, rapid, affordable, and detergent-free method for the analysis of periplasmic proteins from Enterobacteriaceae clinical isolates. This approach may contribute to MS-based clinical diagnostics., (© 2021 Wiley-VCH GmbH.)

The purpose of this study was to test seven constructs (prior experience of exercise, perceived health status, exercise benefits, exercise barriers, exercise self-efficacy, social support for exercise, and options for exercise) from the health promotion model (HPM) as a causal model of commitment to a plan for exercise in a sample of 400 Korean adults with chronic disease. Using structural equation modeling (SEM), we found that all fit indices indicated a good fit. The final model accounted for 54% of the variance in commitment to a plan for exercise. Prior experience with exercise and exercise benefits were the factors most highly related. Health professionals can assess prior experience and emphasize personally relevant benefits of exercise in designing intervention programs to help Korean adults with chronic disease become more physically active.