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5 results on '"James R. Woods"'

2. Agonists of the γ-Aminobutyric Acid Type B (GABA(B)) Receptor Derived from β-Hydroxy and β-Amino Difluoromethyl Ketones

Author

Kuldeep K. Roy, Amy E. Salyer, David A. Colby, James R. Woods, Munia F. Sowaileh, Jinu P. John, Gregory H. Hockerman, and Robert J. Doerksen

Subjects
Agonist, medicine.drug_class, Stereochemistry, Carboxylic acid, Clinical Biochemistry, Pharmaceutical Science, GABAB receptor, 010402 general chemistry, 01 natural sciences, Biochemistry, Aminobutyric acid, Article, chemistry.chemical_compound, Structure-Activity Relationship, GABA receptor, Drug Discovery, medicine, Humans, Receptor, Molecular Biology, chemistry.chemical_classification, Binding Sites, Propylamines, 010405 organic chemistry, Chemistry, Organic Chemistry, Stereoisomerism, Ketones, 0104 chemical sciences, Molecular Docking Simulation, HEK293 Cells, Receptors, GABA-B, Docking (molecular), GABA-B Receptor Agonists, Molecular Medicine, Lead compound
Abstract

β-Hydroxy difluoromethyl ketones represent the newest class of agonists of the GABA-B receptor, and they are structurally distinct from all other known agonists at this receptor because they do not display the carboxylic acid or amino group of γ-aminobutyric acid (GABA). In this report, the design, synthesis, and biological evaluation of additional analogues of β-hydroxy difluoromethyl ketones characterized the critical nature of the substituted aromatic group on the lead compound. The importance of these new data is interpreted by docking studies using the X-ray structure of the GABA-B receptor. Moreover, we also report that the synthesis and biological evaluation of β-amino difluoromethyl ketones provided the most potent compound across these two series.

Published
2018

3. Synthesis of 15-methylene-eburnamonine from (+)-vincamine, evaluation of anticancer activity, and investigation of mechanism of action by quantitative NMR

Author

Melissa A. O’Banion, Mark V. Riofski, James R. Woods, Julia Kirshner, David A. Colby, Mary M. Zheng, and Huaping Mo

Subjects
Steric effects, Models, Molecular, Magnetic Resonance Spectroscopy, Clinical Biochemistry, Vincamine, Pharmaceutical Science, Antineoplastic Agents, Biochemistry, Article, chemistry.chemical_compound, Nucleophile, Cell Line, Tumor, Neoplasms, Drug Discovery, medicine, Organic chemistry, Humans, Methylene, Molecular Biology, Vinca Alkaloids, Peterson olefination, Natural product, Chemistry, Organic Chemistry, Covalent bond, Molecular Medicine, Enone, medicine.drug
Abstract

The biological role of installing a critical exocyclic enone into the structure of the alkaloid, (−)-eburnamonine, and characterization of the new chemical reactivity by quantitative NMR without using deuterated solvents are described. This selective modification to a natural product imparts potent anticancer activity as well as bestows chemical reactivity toward nucleophilic thiols, which was measured by quantitative NMR. The synthetic strategy provides an overall conversion of 40%. In the key synthetic step, a modified Peterson olefination was accomplished through the facile release of trifluoroacetate to create the requisite enone in the presence of substantial steric hindrance.

Published
2013

4. The Handbook of Patient Safety Compliance : A Practical Guide for Health Care Organizations

Author

Fay A. Rozovsky, James R. Woods, Jr, Fay A. Rozovsky, and James R. Woods, Jr

Subjects
Medical errors
Abstract

Written for virtually every professional and leader in the health care field, as well as students who are preparing for careers in health services delivery, this book presents a framework for developing a patient safety program, shows how best to examine events that do occur, and reveals how to ensure that appropriate corrective and preventative actions are reviewed for effectiveness. The book covers a comprehensive selection of topics including The link between patient safety and legal and regulatory compliance The role of accreditation and standard-setting organizations in patient safety Failure modes and effect analysis Voluntary and regulatory oversight of medical error Evidence-based outcomes and standards of care Creation and preservation of reports, data, and device evidence in medical error situations Claims management when dealing with patient safety events Full disclosure Patient safety in human research Managing confidentiality in the face of litigation Managing patient safety compliance through accountability-based credentialing for health care professionals Planning for the future

Published
2005

5. Surgical management of postpartum hemorrhage.

Author

Gilmandyar D and Thornburg LL

Subjects
Female, Guidelines as Topic, Humans, Organ Sparing Treatments, Patient Selection, Pregnancy, Fertility Preservation methods, Hysterectomy methods, Postpartum Hemorrhage surgery, Uterine Artery Embolization methods, Uterus surgery
Abstract

When medical management of PPH is unsuccessful, surgical options should be utilized in a timely fashion in order to reduce maternal morbidity and mortality. This chapter describes ways of effective preparation, mobilization of resources and an organized approach to evaluation and surgical amelioration of PPH. Multiple fertility preserving surgical techniques to control PPH are described. Although a variety of conservative surgical approaches can be used in the setting of PPH, in a hemodynamically unstable patient, readiness for definitive management with a hysterectomy is necessary in order to reduce the risk of maternal mortality., (Copyright © 2018 Elsevier Inc. All rights reserved.)

Published
2019
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