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305 results on '"Jaimes, Edgar A."'

5. Patient-Specific Pharmacokinetics and Dasatinib Nephrotoxicity

Author

Adegbite, Benjamin O., Abramson, Matthew H., Gutgarts, Victoria, Musteata, Florin M., Chauhan, Kinsuk, Muwonge, Alecia N., Meliambro, Kristin A., Salvatore, Steven P., El Ghaity-Beckley, Sebastian, Kremyanskaya, Marina, Marcellino, Bridget, Mascarenhas, John O., Campbell, Kirk N., Chan, Lili, Coca, Steven G., Berman, Ellin M., Jaimes, Edgar A., and Azeloglu, Evren U.

Published
2023
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8. A multi-center study on safety and efficacy of immune checkpoint inhibitors in cancer patients with kidney transplant

Author

Murakami, Naoka, Mulvaney, Patrick, Danesh, Melissa, Abudayyeh, Ala, Diab, Adi, Abdel-Wahab, Noha, Abdelrahim, Maen, Khairallah, Pascale, Shirazian, Shayan, Kukla, Aleksandra, Owoyemi, Itunu O., Alhamad, Tarek, Husami, Samir, Menon, Madhav, Santeusanio, Andrew, Blosser, Christopher D., Zuniga, Sandra Carias, Soler, Maria Jose, Moreso, Francesc, Mithani, Zain, Ortiz-Melo, David, Jaimes, Edgar A., Gutgarts, Victoria, Lum, Erik, Danovitch, Gabriel M., Cardarelli, Francesca, Drews, Reed E., Bassil, Claude, Swank, Jennifer L., Westphal, Scott, Mannon, Roslyn B., Shirai, Keisuke, Kitchlu, Abhijat, Ong, Song, Machado, Shana M., Mothi, Suraj S., Ott, Patrick A., Rahma, Osama, Hodi, F. Stephen, Sise, Meghan E., Gupta, Shruti, Leaf, David E., Devoe, Craig E., Wanchoo, Rimda, Nair, Vinay V., Schmults, Chrysalyne D., Hanna, Glenn J., Sprangers, Ben, Riella, Leonardo V., and Jhaveri, Kenar D.

Published
2021
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9. Impact of Pretransplantation Renal Dysfunction on Outcomes after Allogeneic Hematopoietic Cell Transplantation

Author

Farhadfar, Nosha, Dias, Ajoy, Wang, Tao, Fretham, Caitrin, Chhabra, Saurabh, Murthy, Hemant S., Broglie, Larisa, D'Souza, Anita, Gadalla, Shahinaz M., Gale, Robert Peter, Hashmi, Shahrukh, Al-Homsi, A. Samer, Hildebrandt, Gerhard C., Hematti, Peiman, Rizzieri, David, Chee, Lynette, Lazarus, Hillard M., Bredeson, Christopher, Jaimes, Edgar A., Beitinjaneh, Amer, Bashey, Asad, Prestidge, Tim, Krem, Maxwell M., Marks, David I., Benoit, Stefanie, Yared, Jean A., Nishihori, Taiga, Olsson, Richard F., Freytes, Cesar O., Stadtmauer, Edward, Savani, Bipin N., Sorror, Mohamed L., Ganguly, Siddhartha, Wingard, John R., and Pasquini, Marcelo

Published
2021
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10. KDIGO Controversies Conference on onco-nephrology: kidney disease in hematological malignancies and the burden of cancer after kidney transplantation

Author

Abu-Alfa, Ali K., Amer, Hatem, Beutel, Gernot, Chapman, Jeremy, Chen, Xiaohong, Chudek, Jerzy, Cosmai, Laura, Danesi, Romano, De Stefano, Filippo, Iseki, Kunitoshi, Jaimes, Edgar A., Jhaveri, Kenar D., Jurczyszyn, Artur, Kazancioğlu, Rümeyza, Kitchlu, Abhijat, Kollmannsberger, Christian, Lahoti, Amit, Li, Yang, Macía, Manuel, Matsubara, Takeshi, Mitropoulos, Dionysios, Noiri, Eisei, Perazella, Mark A., Ronco, Pierre, Rosner, Mitchell H., Soler Romeo, Maria Jose, Sprangers, Ben, Stadler, Walter M., Stevens, Paul E., Tesař, Vladimír, Torres da Costa e Silva, Verônica, Vesole, David H., Vijayan, Anitha, Viklický, Ondřej, Workeneh, Biruh T., Yanagita, Motoko, Zakharova, Elena, Małyszko, Jolanta, Bamias, Aristotelis, Danesh, Farhad R., Dębska-Ślizień, Alicja, Gallieni, Maurizio, Gertz, Morie A., Kielstein, Jan T., Tesarova, Petra, Wong, Germaine, Cheung, Michael, Wheeler, David C., Winkelmayer, Wolfgang C., and Porta, Camillo

Published
2020
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11. KDIGO Controversies Conference on onco-nephrology: understanding kidney impairment and solid-organ malignancies, and managing kidney cancer

Author

Abu-Alfa, Ali K., Amer, Hatem, Beutel, Gernot, Chapman, Jeremy, Chen, Xiaohong, Chudek, Jerzy, Cosmai, Laura, Danesi, Romano, De Stefano, Filippo, Iseki, Kunitoshi, Jaimes, Edgar A., Jhaveri, Kenar D., Jurczyszyn, Artur, Kazancioğlu, Rümeyza, Kitchlu, Abhijat, Kollmannsberger, Christian, Lahoti, Amit, Li, Yang, Macía, Manuel, Matsubara, Takeshi, Mitropoulos, Dionysios, Noiri, Eisei, Perazella, Mark A., Ronco, Pierre, Rosner, Mitchell H., Soler Romeo, Maria Jose, Sprangers, Ben, Stadler, Walter M., Stevens, Paul E., ladimír Tesař, Torres da Costa e Silva, Verônica, Vesole, David H., Vijayan, Anitha, Viklický, Ondřej, Workeneh, Biruh T., Yanagita, Motoko, Zakharova, Elena, Porta, Camillo, Bamias, Aristotelis, Danesh, Farhad R., Dębska-Ślizień, Alicja, Gallieni, Maurizio, Gertz, Morie A., Kielstein, Jan T., Tesarova, Petra, Wong, Germaine, Cheung, Michael, Wheeler, David C., Winkelmayer, Wolfgang C., and Małyszko, Jolanta

Published
2020
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19. Early Fluid Overload Is Associated with an Increased Risk of Nonrelapse Mortality after Ex Vivo CD34-Selected Allogeneic Hematopoietic Cell Transplantation

Author

Rondon-Clavo, Carlos, Scordo, Michael, Hilden, Patrick, Shah, Gunjan L., Cho, Christina, Maloy, Molly A., Papadopoulos, Esperanza B., Jakubowski, Ann A., O'Reilly, Richard J., Gyurkocza, Boglarka, Castro-Malaspina, Hugo, Tamari, Roni, Shaffer, Brian C., Perales, Miguel-Angel, Jaimes, Edgar A., and Giralt, Sergio A.

Published
2018
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44. Elevated soluble urokinase plasminogen activator receptor is associated with renal dysfunction in a Chlorocebus atheiopsCOVID‐19 model.

Author

Gonzalez, Alexis A., Olsen, Emily L., Killeen, Stephanie Z., Blair, Robert V., Seshan, Surya V., Jaimes, Edgar A., Roy, Chad J., and Prieto, Minolfa C.

Subjects
PLASMINOGEN activators, KIDNEY diseases, UROKINASE, CERCOPITHECUS aethiops, PLASMINOGEN, PLASMIN, SARS-CoV-2
Abstract

Increases of soluble urokinase plasminogen activator receptor (suPAR) were measured in both urine and plasma of a Chlorocebus aethiops (African green monkey; AGM) mucosal infected with SARS‐CoV‐2. The data indicate that elevated suPAR may be associated with renal dysfunction and pathology in the context of COVID‐19. [ABSTRACT FROM AUTHOR]

Published
2023
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45. Assessment of renal outcome following therapy in monoclonal immunoglobulin deposition disease: Emphasizing the need for a consensus approach.

Author

Pianko, Matthew J., Tiutan, Timothy, Derkach, Andriy, Flynn, Jessica, Salvatore, Steven P., Jaffer‐Sathick, Insara, Rossi, Adriana C., Lahoud, Oscar, Hultcrantz, Malin, Shah, Urvi A., Maclachlan, Kylee, Chung, David J., Shah, Gunjan L., Landau, Heather J., Korde, Neha, Mailankody, Sham, Lesokhin, Alexander M., Tan, Carlyn, Scordo, Michael, and Jaimes, Edgar A.

Published
2023
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48. Campanian-Eocene dinoflagellate cyst biostratigraphy in the Southern Andean foreland basin: Implications for Drake Passage throughflow

Author

Bijl, Peter K., Guerstein, G. Raquel, Jaimes, Edgar A.Sanmiguel, Sluijs, Appy, Casadio, Silvio, Valencia, Víctor, Amenábar, Cecilia R., Encinas, Alfonso, Marine palynology and palaeoceanography, Marine Palynology, Marine palynology and palaeoceanography, and Marine Palynology

Subjects
010506 paleontology, Stratigraphy, Biostratigraphy, 010502 geochemistry & geophysics, 01 natural sciences, Paleontology, Paleoceanography, Ocean gyre, Geochemistry and Petrology, Taverne, Foreland basin, Ciencias Exactas y Naturales, 0105 earth and related environmental sciences, geography, geography.geographical_feature_category, Andean orogeny, Subduction, Drake passage, Radiometric dating, Dinoflagellate cysts, Palaeontology, Geology, Sedimentary rock, Paleogene, Cenozoic, Endemism
Abstract

Fil: Bijl, Peter. Department of Earth Sciences, Laboratory of Palaeobotany and Palynology, Utrecht University. The Netherlands. Fil: Guerstein, Raquel. Departamento de Geología, Universidad Nacional del Sur-Instituto Geológico del Sur, CONICET. Argentina. Fil: Sanmiguel Jaimes, Edgar. Universidad Andres Bello, Facultad de Ingenieria, Autopista Concepción-Talcahuano. Chile. Fil: Sluijs, Appy. Department of Earth Sciences, Laboratory of Palaeobotany and Palynology, Utrecht University. The Netherlands. Fil: Casadio, Silvio. Universidad Nacional de Río Negro, Instituto de Investigación en Paleobiología y Geología. Río Negro, Argentina. Fil: Valencia, Víctor. School of the Environment, Washington State University. USA. Fil: Amenábar, Cecilia. Instituto Antártico Argentino-Instituto de Estudios Andinos Don Pablo Groeber-CONICET-Dpto. Ciencias Geológicas, Universidad de Buenos Aires. Argentina. Fil: Encinas, Alfonso. Departamento de Ciencias de la Tierra, Facultad de Ciencias Químicas, Universidad de Concepción. Chile. The tectonic opening of the Tasmanian Gateway and Drake Passage represented crucial geographic requirements for the Cenozoic development of the Antarctic Circumpolar Current (ACC). Particularly the tectonic complexity of Drake Passage has hampered the exact dating of the opening and deepening phases, and the consequential onset of throughflow of the ACC. One of the obstacles is putting key regional tectonic events, recorded in southern Patagonian sediments, in absolute time. For that purpose, we have collected Campanian-Eocene sediment samples from the Chilean sector of Southern Patagonia. Using U-Pb radiometric dating on zircons and dinoflagellate cyst biostratigraphy, we updated age constraints for the sedimentary formations, and the hiatuses in between. Thick sedimentary packages of shallowmarine and continental sediments were deposited in the foreland basin during the early Campanian, mid-Paleocene, the Paleocene-Eocene boundary interval and the middle Eocene, which represent phases of increased foreland subsidence. We interpret regional sedimentary hiatuses spanning the late Campanian, early-to mid-Paleocene, mid-Eocene and latest Eocene-early Oligocene to indicate times of reduced foreland subsidence, relative to sediment supply. We relate these changes to varying subduction rates and Andean orogeny. Dinoflagellate cyst assemblages suggest that the region was under the influence of the Antarctic-derived waters through the western boundary current of the Subpolar Gyre, developed in the southwest Atlantic Ocean and thus argues for limited throughflow through the Drake Passage until at least the latest Eocene. However, the proliferation of dinoflagellate endemism we record in the southwest Atlantic is coeval with that in the southwest Pacific, and on a species level, dinoflagellate cyst assemblages are the same in these two regions. This suggests that both regions were oceanographically connected throughout the early Paleogene, likely through a shallow opening of a restricted Drake Passage. This implies a continuous surface-water connection between the south Pacific and the South Atlantic throughout the late Cretaceous-early Paleogene.

Published
2021

49. Nicotine worsens the severity of nephropathy in diabetic mice: implications for the progression of kidney disease in smokers

Author

Hua, Ping, Feng, Wenguang, Ji, Shaonin, Raij, Leopoldo, and Jaimes, Edgar A.

Subjects
Kidney diseases -- Risk factors, Kidney diseases -- Development and progression, Kidney diseases -- Research, Nicotine -- Health aspects, Nicotine -- Research, Smokers -- Health aspects, Biological sciences
Abstract

Epidemiological studies have established the role of cigarette smoking as a risk factor in the progression of chronic kidney disease, including diabetic nephropathy. We have previously reported that nicotine promotes mesangial cell proliferation and hypertrophy via activation of non-neuronal nicotinic acetylcholine receptors and that nicotine worsens renal injury in a model of acute glomerulonephritis (Jaimes E, Tian RX, Raij L. Am J Physiol Heart Circ Physiol 292: H76-H82, 2007; Jaimes EA, Tian RX, Joshi M, Raij L. Am J Nephrol 29: 319-326, 2009). These studies were designed to test the hypothesis that nicotine worsens renal injury in db/db mice, a well-established model of diabetic nephropathy, and that reactive oxygen species play an important as mediators of these effects. For these studies, nicotine (100 [micro]g/ml) was administered in the drinking water to control and db/db mice for 10 wk. Blood pressure was measured by the tail-cuff method, and urine was collected for proteinuria. At death, kidneys were collected for histology and molecular biology. The administration of nicotine did not result in significant changes in blood pressure or blood glucose and resulted in cotinine levels similar to those found in the plasma of smokers. In diabetic mice, the administration of nicotine significantly increased urinary protein excretion (1-fold), glomerular hypertrophy, and mesangial area (~20%). These changes were accompanied by significant increases in NADPH oxidase 4 (~30%) and increased nitrotyrosine and Akt expression. In vitro, we determined that nicotine has additive effects to high glucose on reactive oxygen species generation and Akt phosphorylation in human mesangial cells. These findings unveil novel mechanisms that may result in the development of novel strategies in the treatment and prevention of diabetic nephropathy in smokers. reactive oxygen species; tobacco doi: 10.1152/ajprenal.00293.2010.

Published
2010

50. Human glomerular endothelium: interplay among glucose, free fatty acids, angiotensin II, and oxidative stress

Author

Jaimes, Edgar A., Hua, Ping, Tian, Run-Xia, and Raij, Leopoldo

Subjects
Endothelium -- Physiological aspects, Endothelium -- Research, Angiotensin -- Physiological aspects, Angiotensin -- Research, Nitric oxide -- Physiological aspects, Nitric oxide -- Research, Oxidative stress -- Physiological aspects, Oxidative stress -- Control, Oxidative stress -- Research, Biological sciences
Abstract

Am J Physiol Renal Physiol 298: F125-F132, 2010. First published October 28, 2009; doi: 10.1152/ajprenal.00248.2009.--Glomerular endothelial cells (GEC) are strategically situated within the capillary loop and adjacent to the glomerular mesangium. GEC serve as targets of metabolic, biochemical, and hemodynamic signals that regulate the glomerular microcirculation. Unequivocally, hyperglycemia, hypertension, and the local renin-angiotensin system partake in the initiation and progression of diabetic nephropathy (DN). Whether free fatty acids (FFA) and reactive oxygen species (ROS) that have been associated with the endothelial dysfunction of diabetic macrovascular disease also contribute to DN is not known. Since endothelial cells from different organs and from different species may display different phenotypes, we employed human GEC to investigate the effect of high glucose (22.5 mmol/l), FFA (800 [micro]mol/l), and angiotensin II (ANG II; [10.sup.-7] mol/l) on the genesis of ROS and their effects on endothelial nitric oxide synthase (eNOS), cyclooxygenase-2 (COX-2), and the synthesis of prostaglandins (PGs). We demonstrated that high glucose but not high FFA increased the expression of a dysfunctional eNOS as well as increased ROS from NADPH oxidase (100%) and likely from uncoupled eNOS. ANG II also induced ROS from NADPH oxidase. High glucose and ANG II upregulated (100%) COX-2 via ROS and significantly increased the synthesis of prostacyclin ([PGI.sub.2]) by 300%. In contrast, FFA did not upregulate COX-2 but increased [PGI.sub.2] (500%). These novel studies are the first in human GEC that characterize the differential role of FFA, hyperglycemia, and ANG II on the genesis of ROS, COX-2, and PGs and their interplay in the early stages of hyperglcyemia. diabetes; prostaglandins; reactive oxygen species; nitric oxide

Published
2010

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