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1. Arterial bicarbonate is associated with hypoxic burden and uncontrolled hypertension in obstructive sleep apnea - The ESADA cohort

Author

Ding Zou, Ludger Grote, Ozen K. Basoglu, Johan Verbraecken, Sophia Schiza, Pawel Sliwinski, Paschalis Steiropoulos, Carolina Lombardi, Holger Hein, Jean-Louis Pépin, Gianfranco Parati, Walter T. McNicholas, Jan Hedner, P. Steiropoulos, J. Verbraecken, E. Petiet, Georgia Trakada, I. Fietze, T. Penzel, Ondrej Ludka, I. Bouloukaki, S. Schiza, W.T. McNicholas, S. Ryan, R.L. Riha, J.A. Kvamme, L. Grote, J. Hedner, D. Zou, Dirk Pevernagie, S. Bailly, J.L. Pépin, R. Tamisier, H. Hein, O.K. Basoglu, M.S. Tasbakan, J. Buskova, P. Joppa, R. Staats, Dries Testelmans, Haralampos Gouveris, K. Ludwig, C. Lombardi, G. Parati, M.R. Bonsignore, Francesco Fanfulla, M. Drummond, M. van Zeller, W. Randerath, Marcel Treml, Z. Dogas, R. Pecotic, A. Pataka, S. Mihaicuta, U. Anttalainen, T. Saaresranta, P. Sliwinski, SALAS, Danielle, MIAI @ Grenoble Alpes - - MIAI2019 - ANR-19-P3IA-0003 - P3IA - VALID, University of Gothenburg (GU), Ege University [Izmir], University of Antwerp (UA), University of Crete [Heraklion] (UOC), Institute of Tuberculosis and Lung Diseases [Warsaw, Poland] (ITLD), Democritus University of Thrace (DUTH), Istituto Auxologico Italiano IRCCS Ospedale San Luca [Milan, Italy] (IAI), Sleep Disorders Center [Reinbeck, Germany] (SDC), Hypoxie et PhysioPathologie (HP2), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes (UGA), University College Dublin [Dublin] (UCD), ESADA collaborators: P Steiropoulos , J Verbraecken , E Petiet , Georgia Trakada , I Fietze , T Penzel , Ondrej Ludka , I Bouloukaki , S Schiza , W T McNicholas , S Ryan , R L Riha , J A Kvamme , L Grote , J Hedner , D Zou , Dirk Pevernagie , S Bailly , J L Pépin , R Tamisier , H Hein , O K Basoglu , M S Tasbakan , J Buskova , P Joppa , R Staats , Dries Testelmans , Haralampos Gouveris , K Ludwig , C Lombardi , G Parati , M R Bonsignore , Francesco Fanfulla , M Drummond , M van Zeller , W Randerath , Marcel Treml , Z Dogas , R Pecotic , A Pataka , S Mihaicuta , U Anttalainen , T Saaresranta , P Sliwinski, ANR-19-P3IA-0003,MIAI,MIAI @ Grenoble Alpes(2019), ESADA Collaborators, and Testelmans, D

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], Human medicine, General Medicine
Abstract

Objective: Blood bicarbonate concentration plays an important role for obstructive sleep apnea (OSA) patients to maintain acid-base balance. We investigated the association between arterial standard bicarbonate ([HCO3-]) and nocturnal hypoxia as well as comorbid hypertension in OSA.Methods: A cross-sectional analysis of 3329 patients in the European Sleep Apnea Database (ESADA) was performed. Arterial blood gas analysis and lung function test were performed in conjunction with polysomnographic sleep studies. The 4% oxygen desaturation index (ODI), mean and minimum oxygen saturation (SpO2), and percentage of time with SpO2 below 90% (T90%) were used to reflect nocturnal hypoxic burden. Arterial hypertension was defined as a physician diagnosis of hypertension with ongoing antihypertensive medication. Hypertensive patients with SBP/DBP below or above 140/90 mmHg were classified as controlled-, uncontrolled hypertension, respectively.Results: The [HCO3-] level was normal in most patients (average 24.0 +/- 2.5 mmol/L). ODI, T90% increased whereas mean and minimum SpO2 decreased across [HCO3-] tertiles (ANOVA, p = 0.030

Published
2023

2. Obstructive sleep apnoea in adult patients post-tonsillectomy

Author

Carolina Lombardi, J. Verbraecken, Gabriel Roisman, Martin Pretl, Ludger Grote, Zoran Dogas, Pierre Escourrou, Patrick Levy, Pawel Sliwinski, Walter T. McNicholas, Tarja Saaresranta, Renata L. Riha, Daniel Rodenstein, Peretz Lavie, Cristina Esquinas, Jan Hedner, Athanasia Pataka, H. Vrints, A. Vitols, G. Parati, Giedrius Varoneckas, Serafeim Chrysovalantis Kotoulas, Ingo Fietze, R Pływaczewski, Oreste Marrone, Silke Ryan, Rainer Schulz, Ozen K. Basoglu, Jan Zieliński, Richard Staats, Ružena Tkáčová, Paschalis Steiropoulos, J.M. Montserrat, Piotr Bielicki, J.L. Pépin, Thomas Penzel, Lavie Lena, Juan F. Masa, Zuzana Dorkova, Pavol Joppa, Marisa Bonsignore, Mehmet Sezai Taşbakan, Ulla Anttalainen, John A. Kvamme, I Bouloukaki, Ferran Barbé, Brian D. Kent, Sofia Schiza, Riha, R, Kotoulas, S, Pataka, A, Kvamme, J, Joppa, P, Hedner, J, Anttalainen, U, Barbe, F, Bonsignore, M, Basoglu, O, Bielicki, P, Bouloukaki, I, Dogas, Z, Dorkova, Z, Escourrou, P, Fietze, I, Esquinas, C, Grote, L, Kent, B, Lena, L, Lavie, P, Levy, P, Lombardi, C, Marrone, O, Masa, J, Mcnicholas, W, Montserrat, J, Parati, G, Penzel, T, Pepin, J, Plywaczewski, R, Pretl, M, Rodenstein, D, Roisman, G, Ryan, S, Saaresranta, T, Schiza, S, Schulz, R, Sliwinski, P, Staats, R, Steiropoulos, P, Tasbakan, M, Tkacova, R, Varoneckas, G, Verbraecken, J, Vitols, A, Vrints, H, Zielinski, J, SALAS, Danielle, University of Edinburgh, General Hospital of Thessaloniki George Papanikolaou, Førde Central Hospital [Førde, Norway] (FCH), Pavol Jozef Šafárik University, ESADA collaborators: U Anttalainen, F Barbé, M R Bonsignore, O Basoglu , P Bielicki, I Bouloukaki, Z Dogas, Z Dorkova, P Escourrou, I Fietze, C Esquinas, L Grote, B D Kent, Lavie Lena, P Lavie, P Levy, C Lombardi, O Marrone, J F Masa, W T McNicholas, J M Montserrat, G Parati, T Penzel, J L Pépin, R Plywaczewski, M Pretl, D Rodenstein, G Roisman, S Ryan, T Saaresranta, S E Schiza, R Schulz, P Sliwinski, R Staats, P Steiropoulos, M S Tasbakan, R Tkacova, G Varoneckas, J Verbraecken, A Vitols, H Vrints, J Zielinski, Riha R.L., Kotoulas S.-.C., Pataka A., Kvamme J.A., Joppa P., Hedner J., Anttalainen U., Barbe F., Bonsignore M.R., Basoglu O., Bielicki P., Bouloukaki I., Dogas Z., Dorkova Z., Escourrou P., Fietze I., Esquinas C., Grote L., Kent B.D., Lena L., Lavie P., Levy P., Lombardi C., Marrone O., Masa J.F., McNicholas W.T., Montserrat J.M., Parati G., Penzel T., Pepin J.L., Plywaczewski R., Pretl M., Rodenstein D., Roisman G., Ryan S., Saaresranta T., Schiza S.E., Schulz R., Sliwinski P., Staats R., Steiropoulos P., Tasbakan M.S., Tkacova R., Varoneckas G., Verbraecken J., Vitols A., Vrints H., and Zielinski J.

Subjects
Adult, Pediatrics, medicine.medical_specialty, medicine.medical_treatment, [SDV]Life Sciences [q-bio], ESADA, Lymphoid tissue overgrowth, Settore MED/10 - Malattie Dell'Apparato Respiratorio, 03 medical and health sciences, Sleep apnoea, 0302 clinical medicine, medicine, Humans, Mass index, Respiratory system, Tonsillectomy, Sleep Apnea, Obstructive, Adult patients, business.industry, Sleep apnea, General Medicine, medicine.disease, Sleep in non-human animals, respiratory tract diseases, [SDV] Life Sciences [q-bio], Europe, 030228 respiratory system, Diabetes Mellitus, Type 2, Lower prevalence, Airway, business, Sleep, 030217 neurology & neurosurgery
Abstract

Background: The impact of removing the upper airway lymphoid tissue and in particular, tonsillectomy, in adults with OSA has not been demonstrated in large populations. Aims: To compare the severity of OSA and the prevalence of cardiovascular, metabolic and respiratory co-morbidities between patients with OSA who had undergone previous tonsillectomy and those who had not. Methods: The 19,711 participants in this study came from the European sleep apnea database (ESADA) which comprises data from unselected adult patients aged 18–80 years with a history of symptoms suggestive of OSA referred to sleep centers throughout Europe. Results: There were no differences between the two groups in terms of sex ratio and age (146 patients with previous tonsillectomy vs. 19565 patients without). Patients who had undergone tonsillectomy had a lower body mass index (29.3 ± 5.2 kg/m2 vs 32.2 ± 6.6 kg/m2, p < 0.001), lower subjective sleep latency (17.1 ± 17.8 min vs 25.5 ± 30.4 min, p = 0.001), lower ODI (15.7 ± 18.3 events/hour vs 30.7 ± 26.1 events/hour, p < 0.001), and SpO2, European Respiratory Society, ERS, The ESADA network has previously received support from the European Union COST action B26 and the European Respiratory Society. We gratefully acknowledge unrestricted seeding grants from ResMed Inc and Philips Respironics Inc. for establishment of the organisation and the database. Excellent technical assistance in terms of centre monitoring and database maintenance was provided by Ann-Christin Lundquist, RN and Jeanette Norum, RN.

Published
2021

3. Effectiveness of pulmonary rehabilitation in COVID-19 respiratory failure patients post-ICU

Author

Samuel Verges, Y. Al Chikhanie, M. Schoeffler, J.L. Pépin, D. Veale, F. Hérengt, and SALAS, Danielle

Subjects
Pulmonary and Respiratory Medicine, Male, medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), Critical Care, Physiology, medicine.medical_treatment, Short Communication, Walk Test, Respiratory failure, Breathing Exercises, law.invention, 03 medical and health sciences, Walking distance, 0302 clinical medicine, law, medicine, Humans, Pulmonary rehabilitation, Aged, Retrospective Studies, Aged, 80 and over, Rehabilitation, business.industry, General Neuroscience, COVID-19, Functional recovery, Retrospective cohort study, Recovery of Function, Middle Aged, Intensive care unit, Exercise Therapy, [SDV] Life Sciences [q-bio], Intensive Care Units, Treatment Outcome, 030228 respiratory system, Emergency medicine, Female, business, Respiratory Insufficiency, Psychosocial, 030217 neurology & neurosurgery
Abstract

Introduction Some COVID-19 patients develop respiratory failure requiring admission to intensive care unit (ICU). We aim to evaluate the effects of pulmonary rehabilitation (PR) post-ICU in COVID-19 patients. Methods Twenty-one COVID-19 patients were evaluated pre- and post-PR and compared retrospectively to a non−COVID-19 group of 21 patients rehabilitated after ICU admission due to respiratory failure. Results PR induced greater 6-min walking distance improvement in COVID-19 patients (+205 ± 121 m) than in other respiratory failure patients post-ICU (+93 ± 66 m). The sooner PR was performed post-ICU, the better patients recovered. Conclusions PR induced large functional improvements in COVID-19 patients post-ICU although significant physical and psychosocial impairments remained post-PR.

Published
2021

4. Facteurs associés au masque de ventilation non invasive nocturne chez les patients neuromusculaires adultes

Author

Nathalie Arnol, A. Leotard, Marius Lebret, H. Prigent, Frédéric Lofaso, J.L. Pépin, S. Hartley, Jean-Christian Borel, Handicap neuromusculaire : Physiopathologie, Biothérapie et Pharmacologies appliquées (END-ICAP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hypoxie : Physiopathologie Respiratoire et Cardiovasculaire (HP2), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes (UGA), Pôle Thorax et Vaisseaux [CHU Grenoble], and Centre Hospitalier Universitaire [Grenoble] (CHU)

Subjects
Pulmonary and Respiratory Medicine, Gynecology, medicine.medical_specialty, business.industry, [SDV]Life Sciences [q-bio], 3. Good health, 03 medical and health sciences, Nasal mask, 0302 clinical medicine, 030228 respiratory system, medicine, In patient, Noninvasive ventilation, 030212 general & internal medicine, business
Abstract

Resume Chez les patients atteints de maladies neuromusculaires traites par ventilation non invasive (VNI), le choix de l’interface est crucial pour l’efficacite du traitement au long cours. Bien que les masques nasaux soient generalement consideres comme la premiere ligne de traitement, pres d’un tiers des patients atteints de maladies neuromusculaires utilisent une interface oro-nasale. Cependant, les facteurs qui determinent le choix du masque restent mal connus. Nous proposons ici une analyse originale a partir des donnees d’une enquete multicentrique prospective franco-belge qui examine les facteurs lies au type de masque utilise la nuit chez 116 patients adultes neuromusculaires traites par VNI. Chez ces patients, un masque oro-nasal semble plus souvent utilise chez les patients non-Duchenne, plus âges, avec indice de masse corporelle plus eleve, une moindre dependance au ventilateur et une meilleure autonomie des membres superieurs permettant le retrait autonome de l’interface. La realisation d’etudes prospectives controlees pour comparer objectivement l’efficacite et la tolerance des differentes interfaces de VNI dans cette population specifique est encore requise.

Published
2020

5. Long-term positive airway pressure therapy is associated with reduced total cholesterol levels in patients with obstructive sleep apnea : data from the European Sleep Apnea Database (ESADA)

Author

Patrick Levy, Tarja Saaresranta, Renata L. Riha, G. Roisman, Mehmet Sezai Taşbakan, Ulla Anttalainen, Holger Hein, Sébastien Bailly, H. Hein, J.A. Kvamme, F. Barbé, Ding Zou, Silke Ryan, Johan Verbraecken, Pavol Joppa, Paschalis Steiropoulos, Jan Hedner, M. Petitjean, L. Ondrej, P. Steiropoulos, Martin Pretl, Walter T. McNicholas, Canan Gunduz, Piotr Bielicki, Thomas Penzel, E. Petiet, Ludger Grote, G. Varoneckas, P. Sliwinski, J. Verbraecken, O.K. Basoglu, A. Vitols, R. Staats, T. Galic, Izolde Bouloukaki, Athanasia Pataka, M. Drummond, Daniel Rodenstein, Gabriel Roisman, R. Plywaczewski, O. Marrone, Gianfranco Parati, Peretz Lavie, M. van Zeller, Lena Lavie, Carolina Lombardi, Zoran Dogas, J.M. Montserrat, Oreste Marrone, Sofia Schiza, J.F. Masa, R. Tkacova, Georgia Trakada, Marisa Bonsignore, Ozen K. Basoglu, P. Joppa, Rainer Schulz, John A. Kvamme, J.L. Pépin, G. Trakada, Brian D. Kent, Ingo Fietze, U. Anttalainen, European Sleep Apnea Database, UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie, UCL - (SLuc) Service de pneumologie, Gunduz C., Basoglu O.K., Kvamme J.A., Verbraecken J., Anttalainen U., Marrone O., Steiropoulos P., Roisman G., Joppa P., Hein H., Trakada G., Hedner J., Grote L., Petiet E., Montserrat J.M., Fietze I., Penzel T., Ondrej L., Rodenstein D., Masa J.F., Bouloukaki I., Schiza S., Kent B., McNicholas W.T., Ryan S., Riha R.L., Schulz R., Zou D., Pepin J.L., Levy P., Bailly S., Lavie L., Lavie P., Tasbakan M.S., Varoneckas G., Tkacova R., Staats R., Barbe F., Lombardi C., Parati G., Drummond M., van Zeller M., Bonsignore M.R., Petitjean M., Pretl M., Vitols A., Dogas Z., Galic T., Pataka A., Saaresranta T., Plywaczewski R., Sliwinski P., Bielicki P., Gunduz, C, Basoglu, O, Kvamme, J, Verbraecken, J, Anttalainen, U, Marrone, O, Steiropoulos, P, Roisman, G, Joppa, P, Hein, H, Trakada, G, Hedner, J, Grote, L, Petiet, E, Montserrat, J, Fietze, I, Penzel, T, Ludka, O, Rodenstein, D, Masa, J, Bouloukaki, I, Schiza, S, Kent, B, Mcnicholas, W, Ryan, S, Riha, R, Schulz, R, Zou, D, Pepin, J, Levy, P, Bailly, S, Lavie, L, Lavie, P, Tasbakan, M, Varoneckas, G, Tkacova, R, Staats, R, Barbe, F, Lombardi, C, Parati, G, Drummond, M, van Zeller, M, Bonsignore, M, Petitjean, M, Pretl, M, Vitols, A, Dogas, Z, Galic, T, Pataka, A, Saaresranta, T, Plywaczewski, R, Sliwinski, P, Bielicki, P, and Ege Üniversitesi

Subjects
cardiovascular risk, Adult, Male, medicine.medical_specialty, Settore MED/10 - Malattie Dell'Apparato Respiratorio, Positive airway pressure, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Cardiovascular risk, Cholesterol, Hypoxia, Sleep apnea, Humans, positive airway pressure, Prospective Studies, Risk factor, Prospective cohort study, Hypoxia, Aged, Sleep Apnea, Obstructive, Framingham Risk Score, Continuous Positive Airway Pressure, business.industry, hypoxia, Sleep apnea, cholesterol, General Medicine, Middle Aged, medicine.disease, sleep apnea, Cardiovascular risk, Obstructive sleep apnea, Cholesterol, 030228 respiratory system, Patient Compliance, Female, Human medicine, business, Body mass index, 030217 neurology & neurosurgery, Dyslipidemia
Abstract

Background and aim: Obstructive sleep apnea (OSA) is an independent risk factor for dyslipidemia. The current study examined the effects of positive airway pressure (PAP) treatment on lipid status in the European Sleep Apnea Database (ESADA). Methods: The prospective cohort study enrolled 1564 OSA subjects (74% male, mean age 54 ± 11y, body mass index (BMI) 32.7 ± 6.6 kg/m2 and apnea-hypopnea index (AHI) 40.3 ± 24.4 n/h) undergoing PAP therapy for at least three months (mean 377.6 ± 419.5 days). Baseline and follow-up total cholesterol (TC) from nine centers were analyzed. Repeated measures and logistic regression tests (adjusted for age, sex, weight changes, lipid lowering medication, PAP compliance, and treatment duration) were used to compare changes in TC concentration. Incident risk for a coronary heart disease event (CHD) was used to compute a Framingham CHD risk score (estimated from age, BMI, blood pressure, and TC). Results: Adjusted means of TC decreased from 194.2 mg/dl to 189.3 mg/dl during follow-up (p = 0.019). A clinically significant (10%) reduction of TC at PAP follow-up was observed in 422 patients (27%). Duration of PAP therapy was identified as independent predictor for TC reduction, which implies an approximately 10% risk reduction for incident CHD events (from 26.7% to 24.1% in men and from 11.2% to 10.1% in women, p < 0.001 respectively). Conclusion: This observational study demonstrates a reduction of TC after long-term PAP treatment. The close association between TC concentration and cardiovascular (CV) mortality suggests that identification and treatment of OSA may have a beneficial effect on overall CV risk due to this mechanism. This possibility needs to be evaluated in prospective randomized studies. © 2020 Elsevier B.V., ResMed Foundation European Respiratory Society, ERS European Respiratory Society, ERS European Respiratory Society, ERS, The ESADA network has received support from the European Union COST action B26 and the European Respiratory Society (ERS) funded Clinical Research Collaboration (CRC). Unrestricted seeding grants from the ResMed Foundation and the Philips Respironics Foundation for establishment of the database in 2007 and 2011 are gratefully acknowledged. The ESADA network has a scientific collaboration with Bayer AG., Nonfinancial support was provided by the European Sleep Research Society (ESRS) and the European Respiratory Society (ERS) in terms of logistics for communication, meetings and data presentations for the ESADA collaborators., Dr. Verbraecken reports grants and personal fees from ResMed, Bioprojet, Jazz Pharmaceutics; personal fees from Philips, Sanofi, Agfa-Gevaert, grants from AirLiquide; personal fees from Springer, Westfalen Medical, SomnoMed, Vivisol, Total Care, Medidis, Fisher & Paykel, Wave Medical, OSG, Mediq Tefa, NightBalance, Heinen & Löwenstein, AstraZen, Accuramed, Bekaert Deslee Academy and UCB Pharma, outside the submitted work. Dr. Hedner reports grants from ResMed, Philips Respironics, and the European Respiratory Society all related to maintenance of database on behalf of the ESADA group during the conduct of the study. Dr. Grote reports grants from Bayer, Resmed, Respironics/Philips, and from the European Respiratory Society during the conduct of the study; non-financial support and other from Itamar Medical, Resmed, Philips, and Astra Zeneca, outside the submitted work. In addition, Dr. Grote has a patent on sleep apnea therapy licensed. The remaining co-authors have no conflict of interest to declare.

Published
2020

6. Use of the Clinical Global Impression scale in sleep apnea patients - Results from the ESADA database

Author

Marijke Dieltjens, Johan A. Verbraecken, Jan Hedner, Olivier M. Vanderveken, Paschalis Steiropoulos, John A. Kvamme, Tarja Saaresranta, Ruzena Tkacova, Oreste Marrone, Zoran Dogas, Sofia Schiza, Ludger Grote, P. Steiropoulos, J. Verbraecken, E. Petiet, Georgia Trakada, J.M. Montserrat, I. Fietze, T. Penzel, Ondrej Ludka, Daniel Rodenstein, J.F. Masa, I. Bouloukaki, S. Schiza, B. Kent, W.T. McNicholas, S. Ryan, R.L. Riha, J.A. Kvamme, R. Schulz, L. Grote, J. Hedner, Ding Zou, J.L. Pépin, P. Levy, Sebastian Bailly, Lena Lavie, Peretz Lavie, H. Hein, O.K. Basoglu, M.S. Tasbakan, G. Varoneckas, P. Joppa, Ra Tkacova, R. Staats, F. Barbé, C. Lombardi, G. Parati, Marta Drummond, Mafalda van Zeller, M.R. Bonsignore, O. Marrone, P. Escourrou, G. Roisman, M. Pretl, A. Vitols, Z. Dogas, T. Galic, A. Pataka, U. Anttalainen, T. Saaresranta, P. Sliwinski, R. Plywaczewski, P. Bielicki, Jan Zielinski, UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie, UCL - (SLuc) Service de pneumologie, Dieltjens, M, Verbraecken, J, Hedner, J, Vanderveken, O, Steiropoulos, P, Kvamme, J, Saaresranta, T, Tkacova, R, Marrone, O, Dogas, Z, Schiza, S, Grote, L, Petiet, E, Trakada, G, Montserrat, J, Fietze, I, Penzel, T, Ludka, O, Rodenstein, D, Masa, J, Bouloukaki, I, Kent, B, Mcnicholas, W, Ryan, S, Riha, R, Schulz, R, Zou, D, Pepin, J, Levy, P, Bailly, S, Lavie, L, Lavie, P, Hein, H, Basoglu, O, Tasbakan, M, Varoneckas, G, Joppa, P, Staats, R, Barbe, F, Lombardi, C, Parati, G, Drummond, M, van Zeller, M, Bonsignore, M, Escourrou, P, Roisman, G, Pretl, M, Vitols, A, Galic, T, Pataka, A, Anttalainen, U, Sliwinski, P, Plywaczewski, R, Bielicki, P, Zielinski, J, and ESADA Collaborators

Subjects
Adult, Male, Databases, Factual, Polysomnography, Disease, Comorbidity, computer.software_genre, Severity of Illness Index, Comorbidities, 03 medical and health sciences, 0302 clinical medicine, Age, health services administration, mental disorders, Diagnosis, medicine, Humans, Prospective Studies, Disease severity, Aged, Sleep Apnea, Obstructive, Database, medicine.diagnostic_test, business.industry, Epworth Sleepiness Scale, Sleep apnea, Apnea, Gender, General Medicine, Anthropometry, Middle Aged, medicine.disease, ta3124, humanities, respiratory tract diseases, Obstructive sleep apnea, 030228 respiratory system, Clinical Global Impression, Female, Human medicine, Comorbiditie, medicine.symptom, business, computer, 030217 neurology & neurosurgery, Diagnosi
Abstract

Objective/Background: The Clinical Global Impression scale (CGI) reflects the clinician's assessment of the disease impact on patient's global functioning. We assessed predictors of CGI scale rating in patients with obstructive sleep apnea (OSA). Patients/Methods: Consecutive patients with suspected OSA (n = 7581) were identified in the European Sleep Apnea Database (ESADA). Anthropometrics, comorbidities, apnea severity obtained by polygraphy or polysomnography, and daytime sleepiness [Epworth Sleepiness Scale (ESS)] were assessed. The CGI 7-point scale was completed at the end of the diagnostic process (CGI-severity, ie, CGI-S) and, in a sub-population, at treatment follow-up (CGI-Improvement). Results: CGI-S was rated mild to moderate in 44% of patients. CGI rating at any given apnea intensity was worse in women than in men (p < 0.01). Patients undergoing polygraphy (n = 5075) were more frequently rated as severely ill compared to those studied with polysomnography (19.0% vs 13.0%, p < 0.001). In patients aged

Published
2019

7. Republication de : Prise en charge du syndrome d’apnées obstructives du sommeil chez la personne vivant avec un diabète : contexte, dépistage, indications et modalités de traitement. Position de la Société Francophone du Diabète (SFD), de la Société Française de Recherche et Médecine du Sommeil (SFRMS) et de la Société de Pneumologie de Langue Française (SPLF)

Author

Laurence Kessler, A-L Borel, P. Böhme, Pascaline Priou, Paul Valensi, P Darmon, Hélène Hanaire, Antoine Avignon, Frédéric Gagnadoux, Renaud Tamisier, P-Y Benhamou, J.L. Pépin, Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), CHU Grenoble, Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM), Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Laboratory of Fundamental and Applied Bioenergetics = Laboratoire de bioénergétique fondamentale et appliquée (LBFA), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Université de Strasbourg (UNISTRA), CHU Strasbourg, Hôpital Jean Verdier [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université Paris Nord, CRNH-IdF, CINFO, Bondy, France., Aix Marseille Université (AMU), Université d'Angers (UA), Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), and CHU Toulouse [Toulouse]

Subjects
Pulmonary and Respiratory Medicine, Position statement, medicine.medical_specialty, Reprint, Cognitive Neuroscience, [SDV]Life Sciences [q-bio], MEDLINE, Context (language use), 030204 cardiovascular system & hematology, 03 medical and health sciences, Behavioral Neuroscience, 0302 clinical medicine, Diabetes mellitus, medicine, Intensive care medicine, ComputingMilieux_MISCELLANEOUS, business.industry, medicine.disease, 3. Good health, Obstructive sleep apnea, Neuropsychology and Physiological Psychology, 030228 respiratory system, Neurology, Treatment modality, Neurology (clinical), business
Abstract

International audience

Published
2018

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