Search

Your search keyword '"Jünger, Michael"' showing total 385 results
Start Over Author "Jünger, Michael" Language english
385 results on '"Jünger, Michael"'

1. On the history of plasma treatment and comparison of microbiostatic efficacy of a historical high-frequency plasma device with two modern devices

Author

Napp, Judith, Daeschlein, Georg, Napp, Matthias, von Podewils, Sebastian, Gümbel, Denis, Spitzmueller, Romy, Fornaciari, Paolo, Hinz, Peter, and Jünger, Michael

Subjects
plasma medicine, low temperature atmospheric pressure plasma, historic plasma apparatus, antimicrobial efficacy, Medicine, Public aspects of medicine, RA1-1270, Microbiology, QR1-502
Abstract

Background: Cold atmospheric pressure plasma (CAP) with its many bioactive properties has defined a new medical field: the plasma medicine. However, in the related form of high-frequency therapy, CAP was even used briefly a century ago. The aim of this study was to review historic CAP treatments and to obtain data regarding the antimicrobial efficacy of a historical high-frequency plasma device.Methods: First, historic literature regarding the history of CAP treatment was evaluated, because in the modern literature no data were available. Second, the susceptibility of 5 different bacterial wound isolates, cultured on agar, to a historic plasma source (violet wand [VW]) and two modern devices (atmospheric pressure plasma jet [APPJ] and Dielectric Barrier Discharge [DBD]) was analyzed . The obtained inhibition areas (IA) were compared.Results: First, the most convenient popular historical electromedical treatments produced a so-called effluvia by using glass electrodes, related to today’s CAP. Second, all three tested plasma sources showed complete eradication of all tested microbial strains in the treated area. The “historical” cold VW plasma showed antimicrobial effects similar to those of modern APPJ and DBD regarding the diameter of the IA.Conclusion: Some retrograde evidence may be deducted from this, especially for treatment of infectious diseases with historical plasma devices. The underlying technology may serve as model for construction of modern sucessive devices.

Published
2015
Full Text
View/download PDF

3. Translational development of ABCB5+ dermal mesenchymal stem cells for therapeutic induction of angiogenesis in non-healing diabetic foot ulcers

Author

Kerstan, Andreas, Dieter, Kathrin, Niebergall-Roth, Elke, Klingele, Sabrina, Jünger, Michael, Hasslacher, Christoph, Daeschlein, Georg, Stemler, Lutz, Meyer-Pannwitt, Ulrich, Schubert, Kristin, Klausmann, Gerhard, Raab, Titus, Goebeler, Matthias, Kraft, Korinna, Esterlechner, Jasmina, Schröder, Hannes M., Sadeghi, Samar, Ballikaya, Seda, Gasser, Martin, Waaga-Gasser, Ana M., Murphy, George F., Orgill, Dennis P., Frank, Natasha Y., Ganss, Christoph, Scharffetter-Kochanek, Karin, Frank, Markus H., and Kluth, Mark A.

Published
2022
Full Text
View/download PDF

4. Allogeneic ABCB5+ Mesenchymal Stem Cells for Treatment-Refractory Chronic Venous Ulcers: A Phase I/IIa Clinical Trial

Author

Kerstan, Andreas, Dieter, Kathrin, Niebergall-Roth, Elke, Dachtler, Ann-Kathrin, Kraft, Korinna, Stücker, Markus, Daeschlein, Georg, Jünger, Michael, Görge, Tobias, Meyer-Pannwitt, Ulrich, Erfurt-Berge, Cornelia, von Engelhardt, Charlotte, Klare, Andreas, Pfeiffer, Christiane, Esterlechner, Jasmina, Schröder, Hannes M., Gasser, Martin, Waaga-Gasser, Ana M., Goebeler, Matthias, Ballikaya, Seda, Sadeghi, Samar, Murphy, George F., Orgill, Dennis P., Frank, Natasha Y., Ganss, Christoph, Scharffetter-Kochanek, Karin, Frank, Markus H., and Kluth, Mark A.

Published
2022
Full Text
View/download PDF

5. Baseline factors affecting closure of venous leg ulcers

Author

Andersen, Charles A., Anderson, Caesar A., Arenberger, Petr, Aschoff, Roland, Augustin, Matthias, Bakos, Noemi, Beele, Hilde, Bervoets, An, Cavorsi, Joseph, Cazzell, Shawn M., Cetkovska, Petra, Clements, J. Randolph, Cook, Emily A., Deck, Kenneth B., De Conninck, Arlette, Despatis, Marc A., Dhillon, Yadwinder S., Dissemond, Joachim, Dove, Cyaandi, Emmert, Steffen, Eming, Sabine, Ennis, William J., Enriquez, George L., Farber, Alik, Filipovska, Olga, Frykberg, Robert G., Gagnon, Joel J., Galiano, Robert, George, Tobias, Giacalone, Vincent, Gordon, Ian L., Grzela, Tomasz, Hajdu, Csaba, Hanft, Jason R., Homey, Bernhard, Hood, Douglas B., Horn, Thomas, Jimenez, Juan C., Juenger, Michael, Keast, David H., Kemeny, Lajos, Kim, Paul J., Kirsner, Robert S., Kotala, Marek, Lantis, John C., II, Lauf, Laszlo, Lavery, Lawrence, Lawall, Holger, Lawrence, Peter F., Malka, Marcin, Marston, William A., Matejkova, Astrid, Mayer, Perry V., Mikosinski, Jacek, Molyneaux, Michael M., Moore, Michael F., Mostow, Eliot N., Motley, Travis A., Nemes, Edina, Pavlasova, Vera, Quist, Sven, Remenyik, Eva, Reyzelman, Alexander M., Rez, Rita, Rock, Paul B., Ruzicka, Thomas, Rybak, Zbigniew, Shebetka, Karry Ann, Shimozaki, Kenneth K., Simka, Marian, Stuecker, Markus, Stuchlik, David, Swiercz, Pawel, Tassone, John, Jr., Twardowska-Saucha, Krystyna, Van Gils, Carl, Vanscheidt, Wolfgang, Varkonyi, Istvan, Vartivarian, Mher, Vasku, Vladimir, Vayser, Dean, Walters, Jodi, Weichenthal, Michael, Wu, Stephanie C.S., Zenilman, Jonathan M., Zimolova, Radka, Zubilewicz, Tomasz, Galiano, Robert D., Eming, Sabine A., Cargill, D. Innes, Dickerson, Jaime E., Jr., and Slade, Herbert B.

Published
2017
Full Text
View/download PDF

7. Microcirculation disorders of the skin.

Author

Lutze, Stine, Westphal, Thea, Jünger, Michael, and Arnold, Andreas

Abstract

Summary: Changes in the microcirculation of the skin are a frequently observed accompanying phenomenon of many diseases, far beyond the spectrum of dermatological diseases. Not all of these changes are pathological, many are transient and have no serious consequences. This is true for many inflammatory diseases such as psoriasis vulgaris or atopic eczema. However, there are also diseases in which functionally and morphologically recognizable microangiopathies lead to severe disease consequences. One of the most important diseases in this context is systemic sclerosis, an autoimmune systemic disease with multiple organ manifestations. Investigations of the cutaneous microcirculation are of great importance for the initial diagnosis as well as for prognosis and assessment of disease progression. In peripheral hemodynamic disorders such as peripheral arterial disease (PAD) and chronic venous insufficiency (CVI), understanding microcirculatory disturbances also plays an important role in therapy and in monitoring the success of therapeutic interventions. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

8. Mikrozirkulationsstörungen der Haut: Microcirculation disorders of the skin.

Author

Lutze, Stine, Westphal, Thea, Jünger, Michael, and Arnold, Andreas

Abstract

Copyright of Journal der Deutschen Dermatologischen Gesellschaft is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2024
Full Text
View/download PDF

16. A rare case of a patient with PPP syndrome presenting pancreatic pseudocysts, panniculitis, and symptoms of polyarthritis. A radicular cyst of the upper jaw could be another manifestation of the syndrome

Author

Konschake, Wolfgang, Westphal, Thea, Jünger, Michael, Arnold, Andreas, and Lutze, Stine

Subjects
lcsh:R5-920, ghost cells, lcsh:R, pancreatitis, panniculitis, lcsh:Medicine, Case Report, radicular cyst, Case Reports, lcsh:Medicine (General), polyarthritis, PPP syndrome
Abstract

In rare cases, pancreatic enzymes can enter the bloodstream and cause fat necrosis in the bone and tissue leading to a disorder called pancreatitis, panniculitis, and polyarthritis syndrome. Clinicians should have this syndrome in mind when treating patients with pancreatitis.

Published
2020

25. Comments on "An Exact Method for the Minimum Feedback Arc Set Problem".

Author

Grötschel, Martin, Jünger, Michael, and Reinelt, Gerhard

Subjects
COMBINATORIAL optimization, INTEGER programming, ALGORITHMS
Abstract

We comment on the ACM Journal of Experimental Algorithmics article "An Exact Method for the Minimum Feedback Arc Set Problem" by Ali Baharev, Hermann Schichl, Arnold Neumaier, and Tobias Achterberg, and we point out that a straightforward implementation of an algorithm we published in 1985, with the same modern technology as used in the article we address, is competitive and mostly superior. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

33. Translational development of ABCB5+ dermal mesenchymal stem cells for therapeutic induction of angiogenesis in non-healing diabetic foot ulcers.

Author

Kerstan, Andreas, Dieter, Kathrin, Niebergall-Roth, Elke, Klingele, Sabrina, Jünger, Michael, Hasslacher, Christoph, Daeschlein, Georg, Stemler, Lutz, Meyer-Pannwitt, Ulrich, Schubert, Kristin, Klausmann, Gerhard, Raab, Titus, Goebeler, Matthias, Kraft, Korinna, Esterlechner, Jasmina, Schröder, Hannes M., Sadeghi, Samar, Ballikaya, Seda, Gasser, Martin, and Waaga-Gasser, Ana M.

Subjects
DIABETIC foot, WOUND healing, VASCULAR endothelial growth factors, TOPICAL drug administration, NEOVASCULARIZATION, PERFUSION imaging, MESENCHYMAL stem cells
Abstract

Background: While rapid healing of diabetic foot ulcers (DFUs) is highly desirable to avoid infections, amputations and life-threatening complications, DFUs often respond poorly to standard treatment. GMP-manufactured skin-derived ABCB5+ mesenchymal stem cells (MSCs) might provide a new adjunctive DFU treatment, based on their remarkable skin wound homing and engraftment potential, their ability to adaptively respond to inflammatory signals, and their wound healing-promoting efficacy in mouse wound models and human chronic venous ulcers. Methods: The angiogenic potential of ABCB5+ MSCs was characterized with respect to angiogenic factor expression at the mRNA and protein level, in vitro endothelial trans-differentiation and tube formation potential, and perfusion-restoring capacity in a mouse hindlimb ischemia model. Finally, the efficacy and safety of ABCB5+ MSCs for topical adjunctive treatment of chronic, standard therapy-refractory, neuropathic plantar DFUs were assessed in an open-label single-arm clinical trial. Results: Hypoxic incubation of ABCB5+ MSCs led to posttranslational stabilization of the hypoxia-inducible transcription factor 1α (HIF-1α) and upregulation of HIF-1α mRNA levels. HIF-1α pathway activation was accompanied by upregulation of vascular endothelial growth factor (VEGF) transcription and increase in VEGF protein secretion. Upon culture in growth factor-supplemented medium, ABCB5+ MSCs expressed the endothelial-lineage marker CD31, and after seeding on gel matrix, ABCB5+ MSCs demonstrated formation of capillary-like structures comparable with human umbilical vein endothelial cells. Intramuscularly injected ABCB5+ MSCs to mice with surgically induced hindlimb ischemia accelerated perfusion recovery as measured by laser Doppler blood perfusion imaging and enhanced capillary proliferation and vascularization in the ischemic muscles. Adjunctive topical application of ABCB5+ MSCs onto therapy-refractory DFUs elicited median wound surface area reductions from baseline of 59% (full analysis set, n = 23), 64% (per-protocol set, n = 20) and 67% (subgroup of responders, n = 17) at week 12, while no treatment-related adverse events were observed. Conclusions: The present observations identify GMP-manufactured ABCB5+ dermal MSCs as a potential, safe candidate for adjunctive therapy of otherwise incurable DFUs and justify the conduct of a larger, randomized controlled trial to validate the clinical efficacy. Trial registration: ClinicalTrials.gov, NCT03267784, Registered 30 August 2017, https://clinicaltrials.gov/ct2/show/NCT03267784 [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

42. Validation of the psychometric properties of a "Modified Version of the Hornheider Screening Instrument" (HSI‐MV) using a sample of outpatient and inpatient skin tumor patients.

Author

Buchhold, Britta, Lutze, Stine, Freyer‐Adam, Jennis, Jünger, Michael, Ramp, Marleen, Konschake, Wolfgang, Jülich, Andreas, Nordt, Claudia, Peters, Sebastian, Arnold, Andreas, and Hannich, Hans‐Joachim

Abstract

Summary: Background: The basis for adequate psycho‐oncological care is the identification of patients with psychosocial support needs. The German Working Group for Psychooncology also recommends the Hornheider Screening Instrument (HSI) for this purpose. The question, "Is anyone in your family particularly burdened by the hospital stay?" is intended to capture disease‐related family stress. But is this item equally suitable for outpatients and inpatients? The study objective was to examine how replacing the original item affects the test performance of this modified version of the HSI and the frequency of psychosocial stress. Patients and Methods: 92 outpatients and 98 inpatients with skin tumors assessed their psychosocial situation using different questionnaires. Results: Compared to inpatients, less than half as many outpatients answered the item in the affirmative. If the question was replaced by: "Is someone in your family particularly burdened by your disease or the course of the disease?" this setting‐related difference did not arise. The "Alternative item" and the "Modified version of the HIS" (HSI‐MV) proved to be superior to the original item and the original HSI with regard to all examined criteria. Conclusions: The HSI‐MV can be used as a reliable and valid instrument for the systematic assessment of psychosocial care needs in outpatient and inpatient settings. Depending on care capacity, a threshold of ≥ 5 or ≥ 4 is appropriate. In addition to screening, the desire for support should be enquired. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

43. Validierung der psychometrischen Eigenschaften einer „Modifizierten Version des Hornheider Screening‐Instruments" (HSI‐MV) anhand einer Stichprobe ambulanter und stationärer Hauttumorpatienten.

Author

Buchhold, Britta, Lutze, Stine, Freyer‐Adam, Jennis, Jünger, Michael, Ramp, Marleen, Konschake, Wolfgang, Jülich, Andreas, Nordt, Claudia, Peters, Sebastian, Arnold, Andreas, and Hannich, Hans‐Joachim

Abstract

Copyright of Journal der Deutschen Dermatologischen Gesellschaft is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2022
Full Text
View/download PDF

44. Improvement of occupational leg edema and discomforts (RCT).

Author

Hecko, Sophie, Lutze, Stine, Arnold, Andreas, Haase, Hermann, Jünger, Michael, and Riebe, Helene

Subjects
COMPRESSION stockings, EDEMA, CROSSOVER trials, HOSIERY, COMPRESSION therapy
Abstract

BACKGROUND: Edema and subjective leg complaints (e.g. pain, heaviness) after long standing or sitting, are defined as orthostatic leg complaints or occupational edema. Compression hosiery should help to prevent or decrease those symptoms. OBJECTIVE: Assess the effects on leg discomforts and leg volume and wearing comfort in two medical below-knee compression stocking types (A vs. B) with an interface pressure of 18 –20 mmHg and a below-knee-low-pressure support stocking (LPSS) with an interface pressure of 8–10mmHg (C). METHODS: Two different types of below-knee medical compression stockings and a LPSS were examined in this randomized, blinded, crossover trial in volunteers having leg discomforts and edema after being in an upright position during the day. Participants were divided into two cohorts, and each type of stocking was worn for three consecutive days in one week with a subsequent washout phase. The assessment of effects and wearing comfort was ascertained by questionnaires. Volume changes in the lower leg were measured with the Bodytronic 600® (Bauerfeind AG, Zeulenroda, Germany). RESULTS: A significant reduction of lower leg volume (mean stocking A: 204.7 ml; mean stocking B: 153.5 ml; mean stocking C: 48.2 ml) and a significant reduction of the life-quality dimension leg-complaints (p < 0.0001) was achieved by all three types of stockings. Compared to the LPSS both compression stockings decreased the lower leg volume significantly more (p < 0.001) and had a significant better fit (p < 0.001). CONCLUSION: Below-knee medical compression stockings with an interface pressure 18–21mmHg and LPSS with an interface pressure of 8–10 mmHg reduce significantly occupational orthostatic edema and leg discomforts which are due to long standing and sitting activities. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

48. Diagnostics of autoimmune bullous diseases in German dermatology departments

Author

van Beek, Nina, Knuth-Rehr, Diana, Altmeyer, Peter, Assaf, Chalid, Babilas, Philipp, Bayerl, Christiane, Benoit, Sandrine, Dippel, Edgar, Effendy, Isaak, Eming, Rüdiger, Fischer, Matthias, Glaenz, Thomas, Gläser, Regine, Goebeler, Matthias, Gollnick, Harald, Götze, Steven, Gross, Gerd, Hadaschik, Eva, Herbst, Rudolf, Hermes, Barbara, Homey, Bernhard, Hunzelmann, Nico, Jünger, Michael, Kapp, Alexander, Kern, Johannes S., Körber, Andreas, Luger, Thomas, Mechtel, Dirk, Megahed, Mosaad, Moll, Ingrid, Peters, Klaus-Peter, Pfeiffer, Christiane, Ring, Johannes, Röcken, Martin, Sárdy, Miklós, Seitz, Cornelia S., Stadler, Rudolf, Steinbrink, Kerstin, Sticherling, Michael, Szeimies, Rolf-Markus, Tronnier, Michael, Ulrich, Jens, Vogt, Thomas, Wagner, Nicola, Welzel, Julia, Wenzel, Jörg, Wozel, Gottfried, Zouboulis, Christos C., Zillikens, Detlef, and Schmidt, Enno

Published
2012
Full Text
View/download PDF

49. Diagnostik blasenbildender Autoimmundermatosen an deutschen Hautkliniken: Diagnostic of autoimmune bullous diseases in German dermatology departments

Author

van Beek, Nina, Knuth-Rehr, Diana, Altmeyer, Peter, Assaf, Chalid, Babilas, Philipp, Bayerl, Christiane, Benoit, Sandrine, Dippel, Edgar, Effendy, Isaak, Eming, Rüdiger, Fischer, Matthias, Glaenz, Thomas, Gläser, Regine, Goebeler, Matthias, Gollnick, Harald, Götze, Steven, Gross, Gerd, Hadaschik, Eva, Herbst, Rudolf, Hermes, Barbara, Homey, Bernhard, Hunzelmann, Nico, Jünger, Michael, Kapp, Alexander, Kern, Johannes S., Körber, Andreas, Luger, Thomas, Mechtel, Dirk, Megahed, Mosaad, Moll, Ingrid, Peters, Klaus-Peter, Pfeiffer, Christiane, Ring, Johannes, Röcken, Martin, Sárdy, Miklós, Seitz, Cornelia S., Stadler, Rudolf, Steinbrink, Kerstin, Sticherling, Michael, Szeimies, Rolf-Markus, Tronnier, Michael, Ulrich, Jens, Vogt, Thomas, Wagner, Nicola, Welzel, Julia, Wenzel, Jörg, Wozel, Gottfried, Zouboulis, Christos C., Zillikens, Detlef, and Schmidt, Enno

Published
2012
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results