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536 results on '"Jörres, Rudolf A."'

1. Midregional Proatrial Natriuretic Peptide (MRproANP) is associated with vertebral fractures and low bone density in patients with chronic obstructive pulmonary disease (COPD)

Author

Trudzinski, Franziska C., Jörres, Rudolf A., Alter, Peter, Watz, Henrik, Vogelmeier, Claus F., Kauczor, Hans-Ulrich, Thangamani, Subasini, Debic, Manuel, Welte, Tobias, Behr, Jürgen, Kahnert, Kathrin, Bals, Robert, Herr, Christian, Heußel, Claus Peter, Biederer, Jürgen, von Stackelberg, Oyunbileg, Fähndrich, Sebastian, Wouters, Emiel F. M., Waschki, Benjamin, Rabe, Klaus F., Herth, Felix J. F., and Palm, Viktoria

Published
2024
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9. Preoperative risk factors predict perioperative allogenic blood transfusion in patients undergoing primary lung cancer resections: a retrospective cohort study from a high-volume thoracic surgery center

Author

Stoleriu, Mircea Gabriel, Gerckens, Michael, Zimmermann, Julia, Schön, Johannes, Damirov, Fuad, Samm, Nicole, Kovács, Julia, Stacher-Priehse, Elvira, Kellerer, Christina, Jörres, Rudolf A., Kauke, Teresa, Ketscher, Christian, Grützner, Uwe, and Hatz, Rudolf

Published
2023
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12. Impact of long-term exposure to ambient ozone on lung function over a course of 20 years (The ECRHS study): a prospective cohort study in adults

Author

Zhao, Tianyu, Markevych, Iana, Fuertes, Elaine, de Hoogh, Kees, Accordini, Simone, Boudier, Anne, Casas, Lidia, Forsberg, Bertil, Garcia Aymerich, Judith, Gnesi, Marco, Holm, Mathias, Janson, Christer, Jarvis, Deborah, Johannessen, Ane, Jörres, Rudolf A., Karrasch, Stefan, Leynaert, Benedicte, Maldonado Perez, José Antonio, Malinovschi, Andrei, Martínez-Moratalla, Jesús, Modig, Lars, Nowak, Dennis, Potts, James, Probst-Hensch, Nicole, Sánchez-Ramos, José Luis, Siroux, Valerie, Urrutia Landa, Isabel, Vienneau, Danielle, Villani, Simona, Jacquemin, Bénédicte, and Heinrich, Joachim

Published
2023
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25. Implications of Switching from Conventional to Electronic Cigarettes on Quality of Life and Smoking Behaviour: Results from the EQualLife Trial.

Author

Rabenstein, Andrea, Czermak, Lilian, Fischer, Elke, Kahnert, Kathrin, Pogarell, Oliver, Jörres, Rudolf A., Nowak, Dennis, and Rüther, Tobias

Subjects
ELECTRONIC cigarettes, SMOKING, SMOKING cessation, NICOTINE addiction, QUALITY of life
Abstract

Introduction: Electronic cigarettes and "vaping" have become popular since their appearance in Europe and the USA in approximately 2006. They are often perceived as having fewer health risks than conventional cigarettes, which makes them of interest as a support tool in smoking cessation. However, its efficacy regarding cessation or reduction of smoking under real-life conditions remains controversial. Our objective was to clarify this question in an observational study of smoking habits after initiating vaping without targeted intervention, as compared to a validated cessation programme. Methods: From October 2015 to April 2018, 80 subjects (60 in the e-cigarette group and 20 in the supervised smoking cessation group) were included in two trial visits, one at the start of the trial and the second after 3 months, plus 4 questionnaire surveys: at the start of the trial and after a 1, 2, and 3 month period. The questionnaire included a nicotine use inventory, a modified Fagerström test for nicotine dependence, and the WHO-QOL-BREF survey. Results: E-cigarettes were effective, leading to a significant (p < 0.03) reduction (p < 0.03) in tobacco consumption and nicotine dependence, with an abstinence rate of 43% after 3 months. Compared to participants in the smoking cessation programme, their use was not associated with an improvement in quality of life during the quitting attempt, and there were no significant differences in clinical symptoms between groups. The reduction in nicotine dependence was more pronounced (p < 0.012) for the smoking cessation programme, with higher abstinence rates (p = 0.011 after 12 weeks) and lower (p < 0.003) remaining tobacco consumption compared to electronic cigarettes. Discussion/Conclusions: The use of electronic cigarettes reduced nicotine dependence and tobacco consumption, but a supervised smoking cessation programme was superior in terms of achieved cessation in both regards. Electronic cigarettes did not improve the quality of life. Since e-cigarettes could be associated with long-term health risks, their usefulness in smoking cessation remains questionable, and a professionally guided and validated smoking cessation programme still appears to be superior and preferable, in terms of achieved cessation. Although this trial is limited regarding the number of participants and follow-up time, it highlights the need for additional, large clinical trials evaluating the efficacy of e-cigarettes for smoking cessation in comparison to a professionally guided smoking cessation programme. [ABSTRACT FROM AUTHOR]

Published
2024
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26. Automated quantitative thin slice volumetric low dose CT analysis predicts disease severity in COVID-19 patients

Author

Stoleriu, Mircea Gabriel, Gerckens, Michael, Obereisenbuchner, Florian, Zaimova, Iva, Hetrodt, Justin, Mavi, Sarah-Christin, Schmidt, Felicitas, Schoenlebe, Anna Auguste, Heinig-Menhard, Katharina, Koch, Ina, Jörres, Rudolf A, Spiro, Judith, Nowak, Lorenz, Hatz, Rudolf, Behr, Jürgen, Gesierich, Wolfgang, Heiß-Neumann, Marion, and Dinkel, Julien

Published
2021
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30. Measurement of urinary Dickkopf-3 uncovered silent progressive kidney injury in patients with chronic obstructive pulmonary disease

Author

Schunk, Stefan J., Beisswenger, Christoph, Ritzmann, Felix, Herr, Christian, Wagner, Martina, Triem, Sarah, Hütter, Gregor, Schmit, David, Zewinger, Stephen, Sarakpi, Tamim, Honecker, Anja, Mahadevan, Peer, Boor, Peter, Wagenpfeil, Stefan, Jörres, Rudolf, Watz, Henrik, Welte, Tobias, Vogelmeier, Claus F., Gröne, Hermann-Josef, Fliser, Danilo, Speer, Thimoteus, and Bals, Robert

Published
2021
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31. Relationship between clinical and radiological signs of bronchiectasis in COPD patients: Results from COSYCONET

Author

Stefan, Andreas, Robert, Bals, Jürgen, Behr, Kathrin, Kahnert, Burkhard, Bewig, Bahmer, Thomas, Roland, Buhl, Ralf, Ewert, Beate, Stubbe, Joachim H, Ficker, Manfred, Gogol, Christian, Grohé, Rainer, Hauck, Matthias, Held, Berthold, Jany, Markus, Henke, Felix, Herth, Gerd, Höffken, Hugo A, Katus, Anne-Marie, Kirsten, Henrik, Watz, Rembert, Koczulla, Klaus, Kenn, Juliane, Kronsbein, Cornelia, Kropf-Sanchen, Christoph, Lange, Peter, Zabel, Michael, Pfeifer, Winfried J, Randerath, Werner, Seeger, Michael, Studnicka, Christian, Taube, Helmut, Teschler, Hartmut, Timmermann, Christian, Virchow J., Claus, Vogelmeier, Ulrich, Wagner, Tobias, Welte, Hubert, Wirtz, Lehnert, Doris, Struck, Birte, Krabbe, Lenka, Arikan, Barbara, Tobias, Julia, Spangel, Gina, Teng, Julia, Essen, Ruhrlandklinik gGmbH., Pieper, Jeanette, Gleiniger, Margret, Markworth, Britta, Hinz, Zaklina, Hundack-Winter, Petra, Burmann, Ellen, Wons, Katrin, Rieber, Ulrike, Schaufler, Beate, Seibert, Martina, Schwedler, Katrin, Michalewski, Sabine, Rohweder, Sonja, Kiel, Campus, Berger, Patricia, Schottel, Diana, Klöser, Manuel, Janke, Vivien, Untsch, Rosalie, Graf, Jana, Reichel, Anita, Weiß, Gertraud, Traugott, Erich, Ziss, Barbara, Kietzmann, Ilona, Schrade-Illmann, Michaela, Polte, Beate, Böckmann, Cornelia, Hübner, Gudrun, Sterk, Lena, Wirz, Anne, Kahnert, Kathrin, Jörres, Rudolf A., Kauczor, Hans-Ulrich, Biederer, Jürgen, Jobst, Bertram, Alter, Peter, Biertz, Frank, Mertsch, Pontus, Lucke, Tanja, Lutter, Johanna I., Trudzinski, Franziska C., Behr, Jürgen, Bals, Robert, Watz, Henrik, Vogelmeier, Claus F., and Welte, Tobias

Published
2020
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35. CAT score single item analysis in patients with COPD: Results from COSYCONET

Author

Stefan, Andreas, Robert, Bals, Jürgen, Behr, Kathrin, Kahnert, Burkhard, Bewig, Roland, Buhl, Ralf, Ewert, Beate, Stubbe, Ficker, Joachim H., Manfred, Gogol, Christian, Grohé, Rainer, Hauck, Matthias, Held, Berthold, Jany, Markus, Henke, Felix, Herth, Gerd, Höffken, Katus Hugo, A., Anne-Marie, Kirsten, Henrik, Watz, Rembert, Koczulla, Klaus, Kenn, Juliane, Kronsbein, Cornelia, Kropf-Sanchen, Christoph, Lange, Peter, Zabel, Michael, Pfeifer, Randerath Winfried, J., Werner, Seeger, Michael, Studnicka, Christian, Taube, Helmut, Teschler, Hartmut, Timmermann, Christian, Virchow J., Claus, Vogelmeier, Ulrich, Wagner, Tobias, Welte, Hubert, Wirtz, Lehnert, Doris, Struck, Birte, Krabbe, Lenka, Arikan, Barbara, Tobias, Julia, Speth, Kornelia, Pieper, Jeanette, Gleiniger, Margret, Markworth, Britta, Hinz, Zaklina, Burmann, Ellen, Wons, Katrin, Rieber, Ulrike, Schaufler, Beate, Schwedler, Katrin, Michalewski, Sabine, Rohweder, Sonja, Berger, Patricia, Schottel, Diana, Janke, Vivien, Untsch, Rosalie, Graf, Jana, Reichel, Anita, Weiß, Gertraud, Traugott, Erich, Kietzmann, Ilona, Schrade-Illmann, Michaela, Polte, Beate, Hübner, Gudrun, Marietta von Siemens, Sarah, Alter, Peter, Lutter, Johanna I., Kauczor, Hans-Ulrich, Jobst, Bertram, Bals, Robert, Trudzinski, Franziska C., Söhler, Sandra, Behr, Jürgen, Watz, Henrik, Waschki, Benjamin, Bewig, Burkhard, Jones, Paul W., Welte, Tobias, Vogelmeier, Claus F., Jörres, Rudolf A., and Kahnert, Kathrin

Published
2019
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45. Clinical factors linked to the type of respiratory medication in COPD: results from the COSYCONET cohort.

Author

Alter, Peter, Kahnert, Kathrin, Trudzinski, Franziska C., Bals, Robert, Watz, Henrik, Speicher, Tim, Söhler, Sandra, Welte, Tobias, Rabe, Klaus F., Wouters, Emiel F. M., Vogelmeier, Claus F., and Jörres, Rudolf A.

Subjects
OBSTRUCTIVE lung diseases, CHRONIC obstructive pulmonary disease, STAIR climbing, DRUGS
Abstract

Background: The use of maintenance medication in patients with chronic obstructive pulmonary disease (COPD) in real life is known to deviate from recommendations in guidelines, which are largely based on randomized controlled trials and selected populations. Objectives: We used the COSYCONET (CO PD and Sy stemic Consequences – Co morbidities Net work) cohort to analyze factors linked to the use of COPD drugs under non-interventional circumstances. Design: COSYCONET is an ongoing, multi-center, non-interventional cohort of patients with COPD. Methods: Patients with COPD of Global Initiative for Chronic Obstructive Lung Disease (GOLD) grades 0–4 participating in visits 1–5 were included. Data covered the period from 2010 to 2018. Generalized linear models were used to examine the relation of COPD characteristics to different types of respiratory medication. Results: A total of 1043 patients were included. The duration of observation was 4.5 years. Use of respiratory medication depended on GOLD grades 0–4 and groups A-D. Long-acting muscarinic antagonist therapy increased over time, and was associated with low carbon monoxide (CO) diffusing capacity, while inhaled corticosteroid (ICS) use decreased. Active smoking was associated with less maintenance therapy in general, and female sex with less ICS use. From the eight items of the COPD Assessment Test, only hill and stair climbing were consistently linked to treatment. Conclusion: Using data from a large, close to real-life observational cohort, we identified factors linked to the use of various types of respiratory COPD medication. Overall, use was consistent with GOLD recommendations. Beyond this, we identified other correlates of medication use that may help us to understand and improve therapy decisions in clinical practice. Trial registration: ClinicalTrials.gov NCT01245933. [ABSTRACT FROM AUTHOR]

Published
2023
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46. Causes and Risk Factors for Absenteeism among Medical Staff in German Specialized Lung Clinics during the COVID Pandemic.

Author

Piel, Stella, Presotto, Maria A., Jörres, Rudolf A., Karrasch, Stefan, Gesierich, Wolfgang, Bullwinkel, Jörn, Rabe, Klaus F., Hayden, Markus C., Kaestner, Franziska, Harzheim, Dominik, Joves, Biljana, Kempa, Axel T., Ghiani, Alessandro, Neurohr, Claus, Michels, Julia D., Kreuter, Michael, Herth, Felix J.F., and Trudzinski, Franziska C.

Subjects
RISK assessment, IMMUNIZATION, SICK leave, JOB absenteeism, RESEARCH funding, QUESTIONNAIRES, DESCRIPTIVE statistics, LONGITUDINAL method, SURVEYS, QUARANTINE, OCCUPATIONAL exposure, RESEARCH, COVID-19 pandemic, SPECIALTY hospitals
Abstract

Background: Staff shortages pose a major challenge to the health system. Objectives: The objective of this study was to clarify the role of different causative factors we investigated on staff absenteeism during the COVID pandemic. Methods: The prospective multicentre cohort study assessed the private and professional impact of the pandemic on health care workers (HCWs) using a specially developed questionnaire. HCWs from 7 specialist lung clinics throughout Germany were surveyed from December 1 to December 23, 2021. The current analysis addresses pandemic-related absenteeism. Results: 1,134 HCW (55% female; 18.4% male, 26.3% not willing to provide information on age or gender) participated. 72.8% had received at least one vaccination dose at the time of the survey, and 9.4% reported a COVID infection. Of those with positive tests, 98% reported home quarantine for median (IQR) 14 (12–17) days; 10.3% of those who ultimately tested negative also reported quarantine periods of 14 (7–14) days. 32.2% of vaccinated respondents reported absenteeism due to vaccine reactions of 2 (1–3) days. Overall, 37% (n = 420) of HCW reported pandemic-related absenteeism, with 3,524 total days of absenteeism, of which 2,828 were due to illness/quarantine and 696 to vaccination effects. Independent risk factors for COVID-related absenteeism ≥5 days included already having COVID, but also concern about long-term effects of COVID (OR 1,782, p = 0.014); risk factors for vaccine-related absenteeism ≥2 days included concerns of late effects of vaccination (OR 2.2, 95% CI: 1.4–3.1, p < 0.000). Conclusion: Staff shortages due to quarantine or infections and vaccine reactogenicity have put a strain on German respiratory specialists. The fact that staff concerns also contributed to absenteeism may be helpful in managing future pandemic events to minimize staff absenteeism. [ABSTRACT FROM AUTHOR]

Published
2023
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47. Differential Impact of Low Fat-Free Mass in People With COPD Based on BMI Classifications: Results From the COPD and Systemic Consequences-Comorbidities Network

Author

Machado, Felipe V C, Vogelmeier, Claus F, Jörres, Rudolf A, Watz, Henrik, Bals, Robert, Welte, Tobias, Spruit, Martijn A, Alter, Peter, Franssen, Frits M E, RS: NUTRIM - R3 - Respiratory & Age-related Health, and Pulmonologie

Abstract

BACKGROUND: Alterations in body composition, including a low fat-free mass index (FFMI), are common in patients with chronic obstructive pulmonary disease (COPD) and occur regardless of body weight. RESEARCH QUESTION: Is the impact of low FFMI on exercise capacity, health-related quality of life (HRQL) and systemic inflammation different among COPD patients stratified in different body mass index classifications? STUDY DESIGN AND METHODS: We analysed baseline data of COPD patients from the COSYCONET (COPD and Systemic Consequences - Comorbidities Network) cohort. Assessments included lung function, bioelectrical impedance analysis, six-minute walk distance (6MWD), HRQL and inflammatory markers. Patients were stratified in underweight (UW), normal weight (NW), pre-obese (PO) and obese (OB) according to BMI and as presenting low, normal or high FFMI using 25th and 75th percentiles of reference values. Linear mixed models were used to investigate the associations between FFM and fat mass with secondary outcomes in each BMI group. RESULTS: 2137 COPD patients (GOLD 1-4, 61% males, age: 65±8years, FEV1: 52.5±18.8%pred) were included. The proportions of patients in UW, NW, PO and OB groups were 12.3%, 31.3%, 39.6%, 16.8%. The frequency of low FFMI decreased from lower to higher BMI groups (UW:81%, NW:53%, PO:42%, OB:39%). FFM was associated with the 6MWD in the UW group, even when adjusting for a broad set of covariates (P0.32). Fat mass was associated with higher systemic inflammation in the NW and PO groups (P

Published
2023

48. MRI Compared with Low-Dose CT for Incidental Lung Nodule Detection in COPD: A Multicenter Trial

Author

Li, Qian, Zhu, Lin, von Stackelberg, Oyunbileg, Triphan, Simon M. F., Biederer, Jürgen, Weinheimer, Oliver, Eichinger, Monika, Vogelmeier, Claus F., Jörres, Rudolf A., Kauczor, Hans-Ulrich, Heußel, Claus P., Jobst, Bertram J., and Wielpütz, Mark O.

Subjects
Original Research
Abstract

PURPOSE: To investigate morphofunctional chest MRI for the detection and management of incidental pulmonary nodules in participants with chronic obstructive pulmonary disease (COPD). MATERIALS AND METHODS: In this prospective study, 567 participants (mean age, 66 years ± 9 [SD]; 340 men) underwent same-day contrast-enhanced MRI and nonenhanced low-dose CT (LDCT) in a nationwide multicenter trial (clinicaltrials.gov: NCT01245933). Nodule dimensions, morphologic features, and Lung Imaging Reporting and Data System (Lung-RADS) category were assessed at MRI by two blinded radiologists, and consensual LDCT results served as the reference standard. Comparisons were performed using the Student t test, and agreements were assessed using the Cohen weighted κ. RESULTS: A total of 525 nodules larger than 3 mm in diameter were detected at LDCT in 178 participants, with a mean diameter of 7.2 mm ± 6.1 (range, 3.1–63.1 mm). Nodules were not detected in the remaining 389 participants. Sensitivity and positive predictive values with MRI for readers 1 and 2, respectively, were 63.0% and 84.8% and 60.2% and 83.9% for solid nodules (n = 495), 17.6% and 75.0% and 17.6% and 60.0% for part-solid nodules (n = 17), and 7.7% and 100% and 7.7% and 50.0% for ground-glass nodules (n = 13). For nodules 6 mm or greater in diameter, sensitivity and positive predictive values were 73.3% and 92.2% for reader 1 and 71.4% and 93.2% for reader 2, respectively. Readers underestimated the long-axis diameter at MRI by 0.5 mm ± 1.7 (reader 1) and 0.5 mm ± 1.5 (reader 2) compared with LDCT (P < .001). For Lung-RADS categorization per nodule using MRI, there was substantial to perfect interreader agreement (κ = 0.75–1.00) and intermethod agreement compared with LDCT (κ = 0.70–1.00 and 0.69–1.00). CONCLUSION: In a multicenter setting, morphofunctional MRI showed moderate sensitivity for detection of incidental pulmonary nodules in participants with COPD but high agreement with LDCT for Lung-RADS classification of nodules. Clinical trial registration no. NCT01245933 and NCT02629432 Keywords: MRI, CT, Thorax, Lung, Chronic Obstructive Pulmonary Disease, Screening © RSNA, 2023 Supplemental material is available for this article.

Published
2023

49. The German COPD cohort COSYCONET: Aims, methods and descriptive analysis of the study population at baseline

Author

Karch, Annika, Vogelmeier, Claus, Welte, Tobias, Bals, Robert, Kauczor, Hans-Ulrich, Biederer, Jürgen, Heinrich, Joachim, Schulz, Holger, Gläser, Sven, Holle, Rolf, Watz, Henrik, Korn, Stephanie, Adaskina, Nina, Biertz, Frank, Vogel, Charlotte, Vestbo, Jørgen, Wouters, Emiel F.M., Rabe, Klaus Friedrich, Söhler, Sandra, Koch, Armin, and Jörres, Rudolf A.

Published
2016
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