Author: "J, Williams" / Language: english - Searchworks@Jio Institute Digital Library Search Results

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9,287 results on '"J, Williams"'

1. Community-Guided, Autism-Adapted Group Cognitive Behavioral Therapy for Depression in Autistic Youth (CBT-DAY): Preliminary Feasibility, Acceptability, and Efficacy

Author: Jessica M. Schwartzman, Marissa C. Roth, Ann V. Paterson, Alexandra X. Jacobs, and Zachary J. Williams
Abstract: This study examined the preliminary feasibility, acceptability, and efficacy of an autism-adapted cognitive behavioral therapy for depression in autistic youth, CBT-DAY. Twenty-four autistic youth (11-17 years old) participated in the pilot non-randomized trial including 5 cisgender females, 14 cisgender males, and 5 non-binary youth. Youth participated in 12 weeks of, CBT-DAY and youth depressive symptoms (i.e., primary clinical outcome) and emotional reactivity and self-esteem (i.e., intervention mechanisms) were assessed through self-report and caregiver report at four timepoints: baseline (week 0), midpoint (week 6), post-treatment (week 12), and follow-up (week 24). Results suggested that CBT-DAY may be feasible (16.67% attrition) in an outpatient setting and acceptable to adolescents and their caregivers. Bayesian linear mixed-effects models showed that CBT-DAY may be efficacious in targeting emotional reactivity [[beta][subscript T1-T3] = -2.53, CrI[subscript 95%] (-4.62, -0.58), P[subscript d] = 0.995, d = -0.35] and self-esteem [[beta][subscript T1-T3] = -3.57, CrI[subscript 95%] (-5.17, -2.00), P[subscript d] > 0.999, d = -0.47], as well as youth depressive symptom severity [[beta] = -2.72, CrI[subscript 95%] (-3.85, -1.63), P[subscript d] > 0.999]. Treatment gains were maintained at follow-up. A cognitive behavioral group therapy designed for and with autistic people demonstrates promise in targeting emotional reactivity and self-esteem to improve depressive symptom severity in youth. Findings can be leveraged to implement larger, more controlled trials of CBT-DAY. The trial was registered at Clinicaltrials.gov (Identifier: NCT05430022; https://beta.clinicaltrials.gov/study/NCT05430022).
Published: 2024
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2. Using Emotion Coaching to Promote Emotional Regulation for Young Children

Author: Briana J. Williams and Lindsay Poole
Abstract: While children receive most emotional messages from their caregivers, schools provide a unique opportunity to promote social-emotional competence. Early childhood educators and administrators should consider the long-term outcomes of incorporating SEL for young learners and school staff. One strategy to promote young students' social-emotional development is incorporating emotion coaching (EC) into educators' toolboxes. As young children make sense of the world, they look to adults and caregivers to understand and regulate in difficult situations, developing secure attachments to their environments and others around them. In schools, the EC approach uses four steps: (a) recognizing and validating the child's feelings, (b) labeling the feelings and validating, (c) setting limits on behavior, and (d) problem-solving with the child.
Published: 2024

3. Inviting Knowledge: Enhancing Archival Discovery through Information Design

Author: David J. Williams
Abstract: Information design--incorporating research in graphic design, typography, visualization, and usability--is a user experience practice directly applicable to contemporary museums, libraries, and archives. Information design principles and guidelines improve engagement at every point of service, effectively and efficiently complementing the mission of knowledge organizations. This historical survey explores information design in the context of contemporary user experience design, and provides an overview of information design principles and guidelines developed over 40 years of research and professional application. Applying elements of information design to archival finding aids enhances usability, while also preserving descriptive and contextual structures.
Published: 2024
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4. Molecular signatures of cortical expansion in the human foetal brain

Author: G. Ball, S. Oldham, V. Kyriakopoulou, L. Z. J. Williams, V. Karolis, A. Price, J. Hutter, M. L. Seal, A. Alexander-Bloch, J. V. Hajnal, A. D. Edwards, E. C. Robinson, and J. Seidlitz
Subjects: Science
Abstract: Abstract The third trimester of human gestation is characterised by rapid increases in brain volume and cortical surface area. Recent studies have revealed a remarkable molecular diversity across the prenatal cortex but little is known about how this diversity translates into the differential rates of cortical expansion observed during gestation. We present a digital resource, μBrain, to facilitate knowledge translation between molecular and anatomical descriptions of the prenatal brain. Using μBrain, we evaluate the molecular signatures of preferentially-expanded cortical regions, quantified in utero using magnetic resonance imaging. Our findings demonstrate a spatial coupling between areal differences in the timing of neurogenesis and rates of neocortical expansion during gestation. We identify genes, upregulated from mid-gestation, that are highly expressed in rapidly expanding neocortex and implicated in genetic disorders with cognitive sequelae. The μBrain atlas provides a tool to comprehensively map early brain development across domains, model systems and resolution scales.
Published: 2024
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5. Investigating carbonyl compounds above the Amazon rainforest using a proton-transfer-reaction time-of-flight mass spectrometer (PTR-ToF-MS) with NO+ chemical ionization

Author: A. Ringsdorf, A. Edtbauer, B. Holanda, C. Poehlker, M. O. Sá, A. Araújo, J. Kesselmeier, J. Lelieveld, and J. Williams
Subjects: Physics, QC1-999, Chemistry, QD1-999
Abstract: The photochemistry of carbonyl compounds significantly influences tropospheric chemical composition by altering the local oxidative capacity; free radical abundance in the upper troposphere; and formation of ozone, peroxycarboxylic nitric anhydride (PAN), and secondary organic aerosol particles. Carbonyl compounds can be emitted directly from the biosphere into the atmosphere and are formed through photochemical degradation of various precursor compounds. Aldehydes have atmospheric lifetimes of hours to days, whereas ketones persist for up to several weeks. While standard operating conditions for a proton-transfer-reaction time-of-flight mass spectrometer (PTR-ToF-MS) using H3O+ ions are unable to separate aldehydes and ketones, the use of NO+ reagent ions allows for the differential detection of isomeric carbonyl compounds with a high temporal resolution. Here we study the temporal (24 h) and vertical (80–325 m) variability of individual carbonyl compounds in the Amazon rainforest atmosphere with respect to their rainforest-specific sources and sinks. We found strong sources of ketones within or just above the canopy (acetone, methyl ethyl ketone (MEK), and C5 ketones). A common feature of the carbonyls was nocturnal deposition observed by loss rates, most likely since oxidized volatile organic compounds are rapidly metabolized and utilized by the biosphere. With NO+ chemical ionization, we show that the dominant carbonyl species include acetone and propanal, which are present at a ratio of 1 : 10 in the wet-to-dry transition season and 1 : 20 in the dry season.
Published: 2024
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6. Observation of muonic Dalitz decays of chib mesons and precise spectroscopy of hidden-beauty states

Author: The LHCb collaboration, R. Aaij, A. S. W. Abdelmotteleb, C. Abellan Beteta, F. Abudinén, T. Ackernley, A. A. Adefisoye, B. Adeva, M. Adinolfi, P. Adlarson, C. Agapopoulou, C. A. Aidala, Z. Ajaltouni, S. Akar, K. Akiba, P. Albicocco, J. Albrecht, F. Alessio, M. Alexander, Z. Aliouche, P. Alvarez Cartelle, R. Amalric, S. Amato, J. L. Amey, Y. Amhis, L. An, L. Anderlini, M. Andersson, A. Andreianov, P. Andreola, M. Andreotti, D. Andreou, A. Anelli, D. Ao, F. Archilli, M. Argenton, S. Arguedas Cuendis, A. Artamonov, M. Artuso, E. Aslanides, R. Ataíde Da Silva, M. Atzeni, B. Audurier, D. Bacher, I. Bachiller Perea, S. Bachmann, M. Bachmayer, J. J. Back, P. Baladron Rodriguez, V. Balagura, W. Baldini, L. Balzani, H. Bao, J. Baptista de Souza Leite, C. Barbero Pretel, M. Barbetti, I. R. Barbosa, R. J. Barlow, M. Barnyakov, S. Barsuk, W. Barter, M. Bartolini, J. Bartz, J. M. Basels, S. Bashir, G. Bassi, B. Batsukh, P. B. Battista, A. Bay, A. Beck, M. Becker, F. Bedeschi, I. B. Bediaga, N. B. Behling, S. Belin, V. Bellee, K. Belous, I. Belov, I. Belyaev, G. Benane, G. Bencivenni, E. Ben-Haim, A. Berezhnoy, R. Bernet, S. Bernet Andres, A. Bertolin, C. Betancourt, F. Betti, J. Bex, Ia. Bezshyiko, J. Bhom, M. S. Bieker, N. V. Biesuz, P. Billoir, A. Biolchini, M. Birch, F. C. R. Bishop, A. Bitadze, A. Bizzeti, T. Blake, F. Blanc, J. E. Blank, S. Blusk, V. Bocharnikov, J. A. Boelhauve, O. Boente Garcia, T. Boettcher, A. Bohare, A. Boldyrev, C. S. Bolognani, R. Bolzonella, N. Bondar, A. Bordelius, F. Borgato, S. Borghi, M. Borsato, J. T. Borsuk, S. A. Bouchiba, M. Bovill, T. J. V. Bowcock, A. Boyer, C. Bozzi, A. Brea Rodriguez, N. Breer, J. Brodzicka, A. Brossa Gonzalo, J. Brown, D. Brundu, E. Buchanan, A. Buonaura, L. Buonincontri, A. T. Burke, C. Burr, J. S. Butter, J. Buytaert, W. Byczynski, S. Cadeddu, H. Cai, A. C. Caillet, R. Calabrese, S. Calderon Ramirez, L. Calefice, S. Cali, M. Calvi, M. Calvo Gomez, P. Camargo Magalhaes, J. I. Cambon Bouzas, P. Campana, D. H. Campora Perez, A. F. Campoverde Quezada, S. Capelli, L. Capriotti, R. Caravaca-Mora, A. Carbone, L. Carcedo Salgado, R. Cardinale, A. Cardini, P. Carniti, L. Carus, A. Casais Vidal, R. Caspary, G. Casse, J. Castro Godinez, M. Cattaneo, G. Cavallero, V. Cavallini, S. Celani, D. Cervenkov, S. Cesare, A. J. Chadwick, I. Chahrour, M. Charles, Ph. Charpentier, E. Chatzianagnostou, M. Chefdeville, C. Chen, S. Chen, Z. Chen, A. Chernov, S. Chernyshenko, X. Chiotopoulos, V. Chobanova, S. Cholak, M. Chrzaszcz, A. Chubykin, V. Chulikov, P. Ciambrone, X. Cid Vidal, G. Ciezarek, P. Cifra, P. E. L. Clarke, M. Clemencic, H. V. Cliff, J. Closier, C. Cocha Toapaxi, V. Coco, J. Cogan, E. Cogneras, L. Cojocariu, P. Collins, T. Colombo, M. C. Colonna, A. Comerma-Montells, L. Congedo, A. Contu, N. Cooke, I. Corredoira, A. Correia, G. Corti, J. J. Cottee Meldrum, B. Couturier, D. C. Craik, M. Cruz Torres, E. Curras Rivera, R. Currie, C. L. Da Silva, S. Dadabaev, L. Dai, X. Dai, E. Dall’Occo, J. Dalseno, C. D’Ambrosio, J. Daniel, A. Danilina, P. d’Argent, A. Davidson, J. E. Davies, A. Davis, O. De Aguiar Francisco, C. De Angelis, F. De Benedetti, J. de Boer, K. De Bruyn, S. De Capua, M. De Cian, U. De Freitas Carneiro Da Graca, E. De Lucia, J. M. De Miranda, L. De Paula, M. De Serio, P. De Simone, F. De Vellis, J. A. de Vries, F. Debernardis, D. Decamp, V. Dedu, S. Dekkers, L. Del Buono, B. Delaney, H.-P. Dembinski, J. Deng, V. Denysenko, O. Deschamps, F. Dettori, B. Dey, P. Di Nezza, I. Diachkov, S. Didenko, S. Ding, L. Dittmann, V. Dobishuk, A. D. Docheva, C. Dong, A. M. Donohoe, F. Dordei, A. C. dos Reis, A. D. Dowling, W. Duan, P. Duda, M. W. Dudek, L. Dufour, V. Duk, P. Durante, M. M. Duras, J. M. Durham, O. D. Durmus, A. Dziurda, A. Dzyuba, S. Easo, E. Eckstein, U. Egede, A. Egorychev, V. Egorychev, S. Eisenhardt, E. Ejopu, L. Eklund, M. Elashri, J. Ellbracht, S. Ely, A. Ene, E. Epple, J. Eschle, S. Esen, T. Evans, F. Fabiano, L. N. Falcao, Y. Fan, B. Fang, L. Fantini, M. Faria, K. Farmer, D. Fazzini, L. Felkowski, M. Feng, M. Feo, A. Fernandez Casani, M. Fernandez Gomez, A. D. Fernez, F. Ferrari, F. Ferreira Rodrigues, M. Ferrillo, M. Ferro-Luzzi, S. Filippov, R. A. Fini, M. Fiorini, M. Firlej, K. L. Fischer, D. S. Fitzgerald, C. Fitzpatrick, T. Fiutowski, F. Fleuret, M. Fontana, L. F. Foreman, R. Forty, D. Foulds-Holt, V. Franco Lima, M. Franco Sevilla, M. Frank, E. Franzoso, G. Frau, C. Frei, D. A. Friday, J. Fu, Q. Fuehring, Y. Fujii, T. Fulghesu, E. Gabriel, G. Galati, M. D. Galati, A. Gallas Torreira, D. Galli, S. Gambetta, M. Gandelman, P. Gandini, B. Ganie, H. Gao, R. Gao, T. Q. Gao, Y. Gao, M. Garau, L. M. Garcia Martin, P. Garcia Moreno, J. García Pardiñas, K. G. Garg, L. Garrido, C. Gaspar, R. E. Geertsema, L. L. Gerken, E. Gersabeck, M. Gersabeck, T. Gershon, S. G. Ghizzo, Z. Ghorbanimoghaddam, L. Giambastiani, F. I. Giasemis, V. Gibson, H. K. Giemza, A. L. Gilman, M. Giovannetti, A. Gioventù, L. Girardey, P. Gironella Gironell, C. Giugliano, M. A. Giza, E. L. Gkougkousis, F. C. Glaser, V. V. Gligorov, C. Göbel, E. Golobardes, D. Golubkov, A. Golutvin, A. Gomes, S. Gomez Fernandez, F. Goncalves Abrantes, M. Goncerz, G. Gong, J. A. Gooding, I. V. Gorelov, C. Gotti, J. P. Grabowski, L. A. Granado Cardoso, E. Graugés, E. Graverini, L. Grazette, G. Graziani, A. T. Grecu, L. M. Greeven, N. A. Grieser, L. Grillo, S. Gromov, C. Gu, M. Guarise, L. Guerry, M. Guittiere, V. Guliaeva, P. A. Günther, A.-K. Guseinov, E. Gushchin, Y. Guz, T. Gys, K. Habermann, T. Hadavizadeh, C. Hadjivasiliou, G. Haefeli, C. Haen, J. Haimberger, M. Hajheidari, G. H. Hallett, M. M. Halvorsen, P. M. Hamilton, J. Hammerich, Q. Han, X. Han, S. Hansmann-Menzemer, L. Hao, N. Harnew, M. Hartmann, S. Hashmi, J. He, F. Hemmer, C. Henderson, R. D. L. Henderson, A. M. Hennequin, K. Hennessy, L. Henry, J. Herd, P. Herrero Gascon, J. Heuel, A. Hicheur, G. Hijano Mendizabal, D. Hill, S. E. Hollitt, J. Horswill, R. Hou, Y. Hou, N. Howarth, J. Hu, W. Hu, X. Hu, W. Huang, W. Hulsbergen, R. J. Hunter, M. Hushchyn, D. Hutchcroft, M. Idzik, D. Ilin, P. Ilten, A. Inglessi, A. Iniukhin, A. Ishteev, K. Ivshin, R. Jacobsson, H. Jage, S. J. Jaimes Elles, S. Jakobsen, E. Jans, B. K. Jashal, A. Jawahery, V. Jevtic, E. Jiang, X. Jiang, Y. Jiang, Y. J. Jiang, M. John, A. John Rubesh Rajan, D. Johnson, C. R. Jones, T. P. Jones, S. Joshi, B. Jost, J. Juan Castella, N. Jurik, I. Juszczak, D. Kaminaris, S. Kandybei, M. Kane, Y. Kang, C. Kar, M. Karacson, D. Karpenkov, A. Kauniskangas, J. W. Kautz, M. K. Kazanecki, F. Keizer, M. Kenzie, T. Ketel, B. Khanji, A. Kharisova, S. Kholodenko, G. Khreich, T. Kirn, V. S. Kirsebom, O. Kitouni, S. Klaver, N. Kleijne, K. Klimaszewski, M. R. Kmiec, S. Koliiev, L. Kolk, A. Konoplyannikov, P. Kopciewicz, P. Koppenburg, M. Korolev, I. Kostiuk, O. Kot, S. Kotriakhova, A. Kozachuk, P. Kravchenko, L. Kravchuk, M. Kreps, P. Krokovny, W. Krupa, W. Krzemien, O. K. Kshyvanskyi, S. Kubis, M. Kucharczyk, V. Kudryavtsev, E. Kulikova, A. Kupsc, B. K. Kutsenko, D. Lacarrere, P. Laguarta Gonzalez, A. Lai, A. Lampis, D. Lancierini, C. Landesa Gomez, J. J. Lane, R. Lane, G. Lanfranchi, C. Langenbruch, J. Langer, O. Lantwin, T. Latham, F. Lazzari, C. Lazzeroni, R. Le Gac, H. Lee, R. Lefèvre, A. Leflat, S. Legotin, M. Lehuraux, E. Lemos Cid, O. Leroy, T. Lesiak, E. Lesser, B. Leverington, A. Li, C. Li, H. Li, K. Li, L. Li, M. Li, P. Li, P.-R. Li, Q. Li, S. Li, T. Li, Y. Li, Z. Lian, X. Liang, S. Libralon, C. Lin, T. Lin, R. Lindner, V. Lisovskyi, R. Litvinov, F. L. Liu, G. Liu, K. Liu, S. Liu, W. Liu, Y. Liu, Y. L. Liu, A. Lobo Salvia, A. Loi, J. Lomba Castro, T. Long, J. H. Lopes, A. Lopez Huertas, S. López Soliño, Q. Lu, C. Lucarelli, D. Lucchesi, M. Lucio Martinez, V. Lukashenko, Y. Luo, A. Lupato, E. Luppi, K. Lynch, X.-R. Lyu, G. M. Ma, R. Ma, S. Maccolini, F. Machefert, F. Maciuc, B. Mack, I. Mackay, L. M. Mackey, L. R. Madhan Mohan, M. J. Madurai, A. Maevskiy, D. Magdalinski, D. Maisuzenko, M. W. Majewski, J. J. Malczewski, S. Malde, L. Malentacca, A. Malinin, T. Maltsev, G. Manca, G. Mancinelli, C. Mancuso, R. Manera Escalero, D. Manuzzi, D. Marangotto, J. F. Marchand, R. Marchevski, U. Marconi, E. Mariani, S. Mariani, C. Marin Benito, J. Marks, A. M. Marshall, L. Martel, G. Martelli, G. Martellotti, L. Martinazzoli, M. Martinelli, D. Martinez Santos, F. Martinez Vidal, A. Massafferri, R. Matev, A. Mathad, V. Matiunin, C. Matteuzzi, K. R. Mattioli, A. Mauri, E. Maurice, J. Mauricio, P. Mayencourt, J. Mazorra de Cos, M. Mazurek, M. McCann, L. Mcconnell, T. H. McGrath, N. T. McHugh, A. McNab, R. McNulty, B. Meadows, G. Meier, D. Melnychuk, F. M. Meng, M. Merk, A. Merli, L. Meyer Garcia, D. Miao, H. Miao, M. Mikhasenko, D. A. Milanes, A. Minotti, E. Minucci, T. Miralles, B. Mitreska, D. S. Mitzel, A. Modak, R. A. Mohammed, R. D. Moise, S. Mokhnenko, E. F. Molina Cardenas, T. Mombächer, M. Monk, S. Monteil, A. Morcillo Gomez, G. Morello, M. J. Morello, M. P. Morgenthaler, J. Moron, A. B. Morris, A. G. Morris, R. Mountain, H. Mu, Z. M. Mu, E. Muhammad, F. Muheim, M. Mulder, K. Müller, F. Muñoz-Rojas, R. Murta, P. Naik, T. Nakada, R. Nandakumar, T. Nanut, I. Nasteva, M. Needham, N. Neri, S. Neubert, N. Neufeld, P. Neustroev, J. Nicolini, D. Nicotra, E. M. Niel, N. Nikitin, P. Nogarolli, P. Nogga, C. Normand, J. Novoa Fernandez, G. Nowak, C. Nunez, H. N. Nur, A. Oblakowska-Mucha, V. Obraztsov, T. Oeser, S. Okamura, A. Okhotnikov, O. Okhrimenko, R. Oldeman, F. Oliva, M. Olocco, C. J. G. Onderwater, R. H. O’Neil, D. Osthues, J. M. Otalora Goicochea, P. Owen, A. Oyanguren, O. Ozcelik, F. Paciolla, A. Padee, K. O. Padeken, B. Pagare, P. R. Pais, T. Pajero, A. Palano, M. Palutan, G. Panshin, L. Paolucci, A. Papanestis, M. Pappagallo, L. L. Pappalardo, C. Pappenheimer, C. Parkes, B. Passalacqua, G. Passaleva, D. Passaro, A. Pastore, M. Patel, J. Patoc, C. Patrignani, A. Paul, C. J. Pawley, A. Pellegrino, J. Peng, M. Pepe Altarelli, S. Perazzini, D. Pereima, H. Pereira Da Costa, A. Pereiro Castro, P. Perret, A. Perro, K. Petridis, A. Petrolini, J. P. Pfaller, H. Pham, L. Pica, M. Piccini, L. Piccolo, B. Pietrzyk, G. Pietrzyk, D. Pinci, F. Pisani, M. Pizzichemi, V. Placinta, M. Plo Casasus, T. Poeschl, F. Polci, M. Poli Lener, A. Poluektov, N. Polukhina, I. Polyakov, E. Polycarpo, S. Ponce, D. Popov, S. Poslavskii, K. Prasanth, C. Prouve, D. Provenzano, V. Pugatch, G. Punzi, S. Qasim, Q. Q. Qian, W. Qian, N. Qin, S. Qu, R. Quagliani, R. I. Rabadan Trejo, J. H. Rademacker, M. Rama, M. Ramírez García, V. Ramos De Oliveira, M. Ramos Pernas, M. S. Rangel, F. Ratnikov, G. Raven, M. Rebollo De Miguel, F. Redi, J. Reich, F. Reiss, Z. Ren, P. K. Resmi, R. Ribatti, G. R. Ricart, D. Riccardi, S. Ricciardi, K. Richardson, M. Richardson-Slipper, K. Rinnert, P. Robbe, G. Robertson, E. Rodrigues, E. Rodriguez Fernandez, J. A. Rodriguez Lopez, E. Rodriguez Rodriguez, J. Roensch, A. Rogachev, A. Rogovskiy, D. L. Rolf, P. Roloff, V. Romanovskiy, M. Romero Lamas, A. Romero Vidal, G. Romolini, F. Ronchetti, T. Rong, M. Rotondo, S. R. Roy, M. S. Rudolph, M. Ruiz Diaz, R. A. Ruiz Fernandez, J. Ruiz Vidal, A. Ryzhikov, J. Ryzka, J. J. Saavedra-Arias, J. J. Saborido Silva, R. Sadek, N. Sagidova, D. Sahoo, N. Sahoo, B. Saitta, M. Salomoni, I. Sanderswood, R. Santacesaria, C. Santamarina Rios, M. Santimaria, L. Santoro, E. Santovetti, A. Saputi, D. Saranin, A. Sarnatskiy, G. Sarpis, M. Sarpis, C. Satriano, A. Satta, M. Saur, D. Savrina, H. Sazak, L. G. Scantlebury Smead, A. Scarabotto, S. Schael, S. Scherl, M. Schiller, H. Schindler, M. Schmelling, B. Schmidt, S. Schmitt, H. Schmitz, O. Schneider, A. Schopper, N. Schulte, S. Schulte, M. H. Schune, R. Schwemmer, G. Schwering, B. Sciascia, A. Sciuccati, S. Sellam, A. Semennikov, T. Senger, M. Senghi Soares, A. Sergi, N. Serra, L. Sestini, A. Seuthe, Y. Shang, D. M. Shangase, M. Shapkin, R. S. Sharma, I. Shchemerov, L. Shchutska, T. Shears, L. Shekhtman, Z. Shen, S. Sheng, V. Shevchenko, B. Shi, Q. Shi, Y. Shimizu, E. Shmanin, R. Shorkin, J. D. Shupperd, R. Silva Coutinho, G. Simi, S. Simone, N. Skidmore, T. Skwarnicki, M. W. Slater, J. C. Smallwood, E. Smith, K. Smith, M. Smith, A. Snoch, L. Soares Lavra, M. D. Sokoloff, F. J. P. Soler, A. Solomin, A. Solovev, I. Solovyev, R. Song, Y. Song, Y. S. Song, F. L. Souza De Almeida, B. Souza De Paula, E. Spadaro Norella, E. Spedicato, J. G. Speer, E. Spiridenkov, P. Spradlin, V. Sriskaran, F. Stagni, M. Stahl, S. Stahl, S. Stanislaus, E. N. Stein, O. Steinkamp, O. Stenyakin, H. Stevens, D. Strekalina, Y. Su, F. Suljik, J. Sun, L. Sun, Y. Sun, D. Sundfeld, W. Sutcliffe, P. N. Swallow, K. Swientek, F. Swystun, A. Szabelski, T. Szumlak, Y. Tan, M. D. Tat, A. Terentev, F. Terzuoli, F. Teubert, E. Thomas, D. J. D. Thompson, H. Tilquin, V. Tisserand, S. T’Jampens, M. Tobin, L. Tomassetti, G. Tonani, X. Tong, D. Torres Machado, L. Toscano, D. Y. Tou, C. Trippl, G. Tuci, N. Tuning, L. H. Uecker, A. Ukleja, D. J. Unverzagt, E. Ursov, A. Usachov, A. Ustyuzhanin, U. Uwer, V. Vagnoni, V. Valcarce Cadenas, G. Valenti, N. Valls Canudas, H. Van Hecke, E. van Herwijnen, C. B. Van Hulse, R. Van Laak, M. van Veghel, G. Vasquez, R. Vazquez Gomez, P. Vazquez Regueiro, C. Vázquez Sierra, S. Vecchi, J. J. Velthuis, M. Veltri, A. Venkateswaran, M. Verdoglia, M. Vesterinen, D. Vico Benet, P. V. Vidrier Villalba, M. Vieites Diaz, X. Vilasis-Cardona, E. Vilella Figueras, A. Villa, P. Vincent, F. C. Volle, D. vom Bruch, N. Voropaev, K. Vos, G. Vouters, C. Vrahas, J. Wagner, J. Walsh, E. J. Walton, G. Wan, C. Wang, G. Wang, J. Wang, M. Wang, N. W. Wang, R. Wang, X. Wang, X. W. Wang, Y. Wang, Z. Wang, J. A. Ward, M. Waterlaat, N. K. Watson, D. Websdale, Y. Wei, J. Wendel, B. D. C. Westhenry, C. White, M. Whitehead, E. Whiter, A. R. Wiederhold, D. Wiedner, G. Wilkinson, M. K. Wilkinson, M. Williams, M. R. J. Williams, R. Williams, Z. Williams, F. F. Wilson, W. Wislicki, M. Witek, L. Witola, G. Wormser, S. A. Wotton, H. Wu, J. Wu, Y. Wu, Z. Wu, K. Wyllie, S. Xian, Z. Xiang, Y. Xie, A. Xu, J. Xu, L. Xu, M. Xu, Z. Xu, D. Yang, K. Yang, S. Yang, X. Yang, Y. Yang, Z. Yang, V. Yeroshenko, H. Yeung, H. Yin, C. Y. Yu, J. Yu, X. Yuan, Y Yuan, E. Zaffaroni, M. Zavertyaev, M. Zdybal, F. Zenesini, C. Zeng, M. Zeng, C. Zhang, D. Zhang, J. Zhang, L. Zhang, S. Zhang, Y. Zhang, Y. Z. Zhang, Y. Zhao, A. Zharkova, A. Zhelezov, S. Z. Zheng, X. Z. Zheng, Y. Zheng, T. Zhou, X. Zhou, Y. Zhou, V. Zhovkovska, L. Z. Zhu, X. Zhu, V. Zhukov, J. Zhuo, Q. Zou, D. Zuliani, and G. Zunica
Subjects: Hadron-Hadron Scattering, Quarkonium, Spectroscopy, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract: Abstract The decays of the χb1(1P), χb2(1P), χb1(2P) and χb2(2P) mesons into the Υ(1S)μ+μ − final state are observed with a high significance using proton-proton collision data collected with the LHCb detector and corresponding to an integrated luminosity of 9 fb −1. The newly observed decays together with the Υ(2S) → Υ(1S)π+π − and Υ(3S) → Υ(2S)π+π − decay modes are used for precision measurements of the mass and mass splittings for the hidden-beauty states.
Published: 2024
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7. Impact of provision of abdominal aortic calcification results on fruit and vegetable intake: 12-week randomized phase 2 controlled trial

Author: Simone Radavelli-Bagatini, Catherine P. Bondonno, Jack Dalla Via, Marc Sim, Abadi K. Gebre, Lauren C. Blekkenhorst, Emma L. Connolly, Nicola P. Bondonno, John T. Schousboe, Richard J. Woodman, Kun Zhu, Shelby Mullin, Pawel Szulc, Ben Jackson, James Dimmock, Markus P. Schlaich, Kay L. Cox, Douglas P. Kiel, Wai H. Lim, Mandy Stanley, Amanda Devine, Peter L. Thompson, Evan J. Williams, Lisa G. Wood, Moira Sim, Robin M. Daly, Jonathan M. Hodgson, and Joshua R. Lewis
Subjects: Science
Abstract: Abstract Provision of non-invasive vascular imaging results to individuals has been shown to improve cardiovascular disease risk factor control: its impact on diet remains uncertain. In this two-arm, single-blind, parallel, 12-week randomized controlled trial, 240 participants, 57.5% females aged 60–80 y had abdominal aortic calcification and clinical assessments performed at a hospital clinic. Participants were randomized 1:1 to receive (intervention n = 121) or not (control n = 119) their calcification results. Both groups received educational resources on cardiovascular disease risk control and were unblinded to the intervention. Outcome measures were performed at baseline and 12 weeks. The primary outcomes of the study were changes in fruit and vegetable intake measures over 12 weeks assessed using plasma carotenoid concentrations (biomarkers of FV intake) and a food frequency questionnaire. Secondary outcomes included 12-week changes in other aspects of the diet, physical activity, body weight, blood pressure, heart rate, lipid profile, glucose concentrations, estimated cardiovascular disease risk score, and medication use. Between-group differences were tested using linear mixed-effects regression. There were no between-group differences in the primary outcomes at 12 weeks: plasma carotenoids (mean difference +0.03 µg/mL [95%CI −0.06, 0.13]) and fruit and vegetable intakes (+18 g/d [−37, 72]). However, the provision of calcification results led to between-group differences in serum total (−0.22 mmol/L [−0.41, −0.04]) and non-HDL (−0.19 mmol/L [−0.35, −0.03]) cholesterol, and estimated cardiovascular disease risk score (−0.24% [−0.47, −0.02]). No between-group differences were seen for other secondary outcomes. In this work, providing vascular imaging results did not improve diet but did improve some cardiovascular disease risk factors (Australian and New Zealand Clinical Trials Registry ACTRN12618001087246).
Published: 2024
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8. Inferring replication timing and proliferation dynamics from single-cell DNA sequencing data

Author: Adam C. Weiner, Marc J. Williams, Hongyu Shi, Ignacio Vázquez-García, Sohrab Salehi, Nicole Rusk, Samuel Aparicio, Sohrab P. Shah, and Andrew McPherson
Subjects: Science
Abstract: Abstract Dysregulated DNA replication is a cause and a consequence of aneuploidy in cancer, yet the interplay between copy number alterations (CNAs), replication timing (RT) and cell cycle dynamics remain understudied in aneuploid tumors. We developed a probabilistic method, PERT, for simultaneous inference of cell-specific replication and copy number states from single-cell whole genome sequencing (scWGS) data. We used PERT to investigate clone-specific RT and proliferation dynamics in >50,000 cells obtained from aneuploid and clonally heterogeneous cell lines, xenografts and primary cancers. We observed bidirectional relationships between RT and CNAs, with CNAs affecting X-inactivation producing the largest RT shifts. Additionally, we found that clone-specific S-phase enrichment positively correlated with ground-truth proliferation rates in genomically stable but not unstable cells. Together, these results demonstrate robust computational identification of S-phase cells from scWGS data, and highlight the importance of RT and cell cycle properties in studying the genomic evolution of aneuploid tumors.
Published: 2024
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9. Transverse polarization measurement of Λ hyperons in pNe collisions at s NN $$ \sqrt{{\textrm{s}}_{\textrm{NN}}} $$ = 68.4 GeV with the LHCb detector

Author: The LHCb collaboration, R. Aaij, A. S. W. Abdelmotteleb, C. Abellan Beteta, F. Abudinén, T. Ackernley, A. A. Adefisoye, B. Adeva, M. Adinolfi, P. Adlarson, C. Agapopoulou, C. A. Aidala, Z. Ajaltouni, S. Akar, K. Akiba, P. Albicocco, J. Albrecht, F. Alessio, M. Alexander, Z. Aliouche, P. Alvarez Cartelle, R. Amalric, S. Amato, J. L. Amey, Y. Amhis, L. An, L. Anderlini, M. Andersson, A. Andreianov, P. Andreola, M. Andreotti, D. Andreou, A. Anelli, D. Ao, F. Archilli, M. Argenton, S. Arguedas Cuendis, A. Artamonov, M. Artuso, E. Aslanides, R. Ataide Da Silva, M. Atzeni, B. Audurier, D. Bacher, I. Bachiller Perea, S. Bachmann, M. Bachmayer, J. J. Back, P. Baladron Rodriguez, V. Balagura, W. Baldini, H. Bao, J. Baptista de Souza Leite, M. Barbetti, I. R. Barbosa, R. J. Barlow, M. Barnyakov, S. Barsuk, W. Barter, M. Bartolini, J. Bartz, J. M. Basels, G. Bassi, B. Batsukh, A. Bay, A. Beck, M. Becker, F. Bedeschi, I. B. Bediaga, S. Belin, V. Bellee, K. Belous, I. Belov, I. Belyaev, G. Benane, G. Bencivenni, E. Ben-Haim, A. Berezhnoy, R. Bernet, S. Bernet Andres, A. Bertolin, C. Betancourt, F. Betti, J. Bex, Ia. Bezshyiko, J. Bhom, M. S. Bieker, N. V. Biesuz, P. Billoir, A. Biolchini, M. Birch, F. C. R. Bishop, A. Bitadze, A. Bizzeti, T. Blake, F. Blanc, J. E. Blank, S. Blusk, V. Bocharnikov, J. A. Boelhauve, O. Boente Garcia, T. Boettcher, A. Bohare, A. Boldyrev, C. S. Bolognani, R. Bolzonella, N. Bondar, F. Borgato, S. Borghi, M. Borsato, J. T. Borsuk, S. A. Bouchiba, T. J. V. Bowcock, A. Boyer, C. Bozzi, A. Brea Rodriguez, N. Breer, J. Brodzicka, A. Brossa Gonzalo, J. Brown, D. Brundu, E. Buchanan, A. Buonaura, L. Buonincontri, A. T. Burke, C. Burr, A. Butkevich, J. S. Butter, J. Buytaert, W. Byczynski, S. Cadeddu, H. Cai, R. Calabrese, S. Calderon Ramirez, L. Calefice, S. Cali, M. Calvi, M. Calvo Gomez, P. Camargo Magalhaes, J. I. Cambon Bouzas, P. Campana, D. H. Campora Perez, A. F. Campoverde Quezada, S. Capelli, L. Capriotti, R. Caravaca-Mora, A. Carbone, L. Carcedo Salgado, R. Cardinale, A. Cardini, P. Carniti, L. Carus, A. Casais Vidal, R. Caspary, G. Casse, J. Castro Godinez, M. Cattaneo, G. Cavallero, V. Cavallini, S. Celani, D. Cervenkov, S. Cesare, A. J. Chadwick, I. Chahrour, M. Charles, Ph. Charpentier, E. Chatzianagnostou, C. A. Chavez Barajas, M. Chefdeville, C. Chen, S. Chen, Z. Chen, A. Chernov, S. Chernyshenko, V. Chobanova, S. Cholak, M. Chrzaszcz, A. Chubykin, V. Chulikov, P. Ciambrone, X. Cid Vidal, G. Ciezarek, P. Cifra, P. E. L. Clarke, M. Clemencic, H. V. Cliff, J. Closier, C. Cocha Toapaxi, V. Coco, J. Cogan, E. Cogneras, L. Cojocariu, P. Collins, T. Colombo, A. Comerma-Montells, L. Congedo, A. Contu, N. Cooke, I. Corredoira, A. Correia, G. Corti, J. J. Cottee Meldrum, B. Couturier, D. C. Craik, M. Cruz Torres, E. Curras Rivera, R. Currie, C. L. Da Silva, S. Dadabaev, L. Dai, X. Dai, E. Dall’Occo, J. Dalseno, C. D’Ambrosio, J. Daniel, A. Danilina, P. d’Argent, A. Davidson, J. E. Davies, A. Davis, O. De Aguiar Francisco, C. De Angelis, F. De Benedetti, J. de Boer, K. De Bruyn, S. De Capua, M. De Cian, U. De Freitas Carneiro Da Graca, E. De Lucia, J. M. De Miranda, L. De Paula, M. De Serio, P. De Simone, F. De Vellis, J. A. de Vries, F. Debernardis, D. Decamp, V. Dedu, L. Del Buono, B. Delaney, H.-P. Dembinski, J. Deng, V. Denysenko, O. Deschamps, F. Dettori, B. Dey, P. Di Nezza, I. Diachkov, S. Didenko, S. Ding, L. Dittmann, V. Dobishuk, A. D. Docheva, C. Dong, A. M. Donohoe, F. Dordei, A. C. dos Reis, A. D. Dowling, W. Duan, P. Duda, M. W. Dudek, L. Dufour, V. Duk, P. Durante, M. M. Duras, J. M. Durham, O. D. Durmus, A. Dziurda, A. Dzyuba, S. Easo, E. Eckstein, U. Egede, A. Egorychev, V. Egorychev, S. Eisenhardt, E. Ejopu, L. Eklund, M. Elashri, J. Ellbracht, S. Ely, A. Ene, E. Epple, J. Eschle, S. Esen, T. Evans, F. Fabiano, L. N. Falcao, Y. Fan, B. Fang, L. Fantini, M. Faria, K. Farmer, D. Fazzini, L. Felkowski, M. Feng, M. Feo, M. Fernandez Gomez, A. D. Fernez, F. Ferrari, F. Ferreira Rodrigues, M. Ferrillo, M. Ferro-Luzzi, S. Filippov, R. A. Fini, M. Fiorini, K. M. Fischer, D. S. Fitzgerald, C. Fitzpatrick, F. Fleuret, M. Fontana, L. F. Foreman, R. Forty, D. Foulds-Holt, M. Franco Sevilla, M. Frank, E. Franzoso, G. Frau, C. Frei, D. A. Friday, J. Fu, Q. Fuehring, Y. Fujii, T. Fulghesu, E. Gabriel, G. Galati, M. D. Galati, A. Gallas Torreira, D. Galli, S. Gambetta, M. Gandelman, P. Gandini, B. Ganie, H. Gao, R. Gao, Y. Gao, M. Garau, L. M. Garcia Martin, P. Garcia Moreno, J. García Pardiñas, K. G. Garg, L. Garrido, C. Gaspar, R. E. Geertsema, L. L. Gerken, E. Gersabeck, M. Gersabeck, T. Gershon, Z. Ghorbanimoghaddam, L. Giambastiani, F. I. Giasemis, V. Gibson, H. K. Giemza, A. L. Gilman, M. Giovannetti, A. Gioventù, P. Gironella Gironell, C. Giugliano, M. A. Giza, E. L. Gkougkousis, F. C. Glaser, V. V. Gligorov, C. Göbel, E. Golobardes, D. Golubkov, A. Golutvin, A. Gomes, S. Gomez Fernandez, F. Goncalves Abrantes, M. Goncerz, G. Gong, J. A. Gooding, I. V. Gorelov, C. Gotti, J. P. Grabowski, L. A. Granado Cardoso, E. Graugés, E. Graverini, L. Grazette, G. Graziani, A. T. Grecu, L. M. Greeven, N. A. Grieser, L. Grillo, S. Gromov, C. Gu, M. Guarise, M. Guittiere, V. Guliaeva, P. A. Günther, A.-K. Guseinov, E. Gushchin, Y. Guz, T. Gys, K. Habermann, T. Hadavizadeh, C. Hadjivasiliou, G. Haefeli, C. Haen, J. Haimberger, M. Hajheidari, M. M. Halvorsen, P. M. Hamilton, J. Hammerich, Q. Han, X. Han, S. Hansmann-Menzemer, L. Hao, N. Harnew, M. Hartmann, J. He, F. Hemmer, C. Henderson, R. D. L. Henderson, A. M. Hennequin, K. Hennessy, L. Henry, J. Herd, P. Herrero Gascon, J. Heuel, A. Hicheur, G. Hijano Mendizabal, D. Hill, S. E. Hollitt, J. Horswill, R. Hou, Y. Hou, N. Howarth, J. Hu, W. Hu, X. Hu, W. Huang, W. Hulsbergen, R. J. Hunter, M. Hushchyn, D. Hutchcroft, D. Ilin, P. Ilten, A. Inglessi, A. Iniukhin, A. Ishteev, K. Ivshin, R. Jacobsson, H. Jage, S. J. Jaimes Elles, S. Jakobsen, E. Jans, B. K. Jashal, A. Jawahery, V. Jevtic, E. Jiang, X. Jiang, Y. Jiang, Y. J. Jiang, M. John, D. Johnson, C. R. Jones, T. P. Jones, S. Joshi, B. Jost, N. Jurik, I. Juszczak, D. Kaminaris, S. Kandybei, Y. Kang, C. Kar, M. Karacson, D. Karpenkov, A. Kauniskangas, J. W. Kautz, F. Keizer, M. Kenzie, T. Ketel, B. Khanji, A. Kharisova, S. Kholodenko, G. Khreich, T. Kirn, V. S. Kirsebom, O. Kitouni, S. Klaver, N. Kleijne, K. Klimaszewski, M. R. Kmiec, S. Koliiev, L. Kolk, A. Konoplyannikov, P. Kopciewicz, P. Koppenburg, M. Korolev, I. Kostiuk, O. Kot, S. Kotriakhova, A. Kozachuk, P. Kravchenko, L. Kravchuk, M. Kreps, P. Krokovny, W. Krupa, W. Krzemien, O. K. Kshyvanskyi, J. Kubat, S. Kubis, M. Kucharczyk, V. Kudryavtsev, E. Kulikova, A. Kupsc, B. K. Kutsenko, D. Lacarrere, A. Lai, A. Lampis, D. Lancierini, C. Landesa Gomez, J. J. Lane, R. Lane, C. Langenbruch, J. Langer, O. Lantwin, T. Latham, F. Lazzari, C. Lazzeroni, R. Le Gac, R. Lefèvre, A. Leflat, S. Legotin, M. Lehuraux, E. Lemos Cid, O. Leroy, T. Lesiak, B. Leverington, A. Li, H. Li, K. Li, L. Li, P. Li, P.-R. Li, Q. Li, S. Li, T. Li, Y. Li, Z. Lian, X. Liang, S. Libralon, C. Lin, T. Lin, R. Lindner, V. Lisovskyi, R. Litvinov, F. L. Liu, G. Liu, K. Liu, S. Liu, Y. Liu, Y. L. Liu, A. Lobo Salvia, A. Loi, J. Lomba Castro, T. Long, J. H. Lopes, A. Lopez Huertas, S. López Soliño, C. Lucarelli, D. Lucchesi, M. Lucio Martinez, V. Lukashenko, Y. Luo, A. Lupato, E. Luppi, K. Lynch, X.-R. Lyu, G. M. Ma, R. Ma, S. Maccolini, F. Machefert, F. Maciuc, B. Mack, I. Mackay, L. M. Mackey, L. R. Madhan Mohan, M. M. Madurai, A. Maevskiy, D. Magdalinski, D. Maisuzenko, M. W. Majewski, J. J. Malczewski, S. Malde, L. Malentacca, A. Malinin, T. Maltsev, G. Manca, G. Mancinelli, C. Mancuso, R. Manera Escalero, D. Manuzzi, D. Marangotto, J. F. Marchand, R. Marchevski, U. Marconi, S. Mariani, C. Marin Benito, J. Marks, A. M. Marshall, G. Martelli, G. Martellotti, L. Martinazzoli, M. Martinelli, D. Martinez Santos, F. Martinez Vidal, A. Massafferri, R. Matev, A. Mathad, V. Matiunin, C. Matteuzzi, K. R. Mattioli, A. Mauri, E. Maurice, J. Mauricio, P. Mayencourt, M. Mazurek, M. McCann, L. Mcconnell, T. H. McGrath, N. T. McHugh, A. McNab, R. McNulty, B. Meadows, G. Meier, D. Melnychuk, F. M. Meng, M. Merk, A. Merli, L. Meyer Garcia, D. Miao, H. Miao, M. Mikhasenko, D. A. Milanes, A. Minotti, E. Minucci, T. Miralles, B. Mitreska, D. S. Mitzel, A. Modak, A. Mödden, R. A. Mohammed, R. D. Moise, S. Mokhnenko, T. Mombächer, M. Monk, S. Monteil, A. Morcillo Gomez, G. Morello, M. J. Morello, M. P. Morgenthaler, A. B. Morris, A. G. Morris, R. Mountain, H. Mu, Z. M. Mu, E. Muhammad, F. Muheim, M. Mulder, K. Müller, F. Muñoz-Rojas, R. Murta, P. Naik, T. Nakada, R. Nandakumar, T. Nanut, I. Nasteva, M. Needham, N. Neri, S. Neubert, N. Neufeld, P. Neustroev, J. Nicolini, D. Nicotra, E. M. Niel, N. Nikitin, P. Nogarolli, P. Nogga, N. S. Nolte, C. Normand, J. Novoa Fernandez, G. Nowak, C. Nunez, H. N. Nur, A. Oblakowska-Mucha, V. Obraztsov, T. Oeser, S. Okamura, A. Okhotnikov, O. Okhrimenko, R. Oldeman, F. Oliva, M. Olocco, C. J. G. Onderwater, R. H. O’Neil, J. M. Otalora Goicochea, P. Owen, A. Oyanguren, O. Ozcelik, K. O. Padeken, B. Pagare, P. R. Pais, T. Pajero, A. Palano, M. Palutan, G. Panshin, L. Paolucci, A. Papanestis, M. Pappagallo, L. L. Pappalardo, C. Pappenheimer, C. Parkes, B. Passalacqua, G. Passaleva, D. Passaro, A. Pastore, M. Patel, J. Patoc, C. Patrignani, A. Paul, C. J. Pawley, A. Pellegrino, J. Peng, M. Pepe Altarelli, S. Perazzini, D. Pereima, H. Pereira Da Costa, A. Pereiro Castro, P. Perret, A. Perro, K. Petridis, A. Petrolini, J. P. Pfaller, H. Pham, L. Pica, M. Piccini, B. Pietrzyk, G. Pietrzyk, D. Pinci, F. Pisani, M. Pizzichemi, V. Placinta, M. Plo Casasus, F. Polci, M. Poli Lener, A. Poluektov, N. Polukhina, I. Polyakov, E. Polycarpo, S. Ponce, D. Popov, S. Poslavskii, K. Prasanth, C. Prouve, V. Pugatch, G. Punzi, S. Qasim, Q. Q. Qian, W. Qian, N. Qin, S. Qu, R. Quagliani, R. I. Rabadan Trejo, J. H. Rademacker, M. Rama, M. Ramírez García, V. Ramos De Oliveira, M. Ramos Pernas, M. S. Rangel, F. Ratnikov, G. Raven, M. Rebollo De Miguel, F. Redi, J. Reich, F. Reiss, Z. Ren, P. K. Resmi, R. Ribatti, G. R. Ricart, D. Riccardi, S. Ricciardi, K. Richardson, M. Richardson-Slipper, K. Rinnert, P. Robbe, G. Robertson, E. Rodrigues, E. Rodriguez Fernandez, J. A. Rodriguez Lopez, E. Rodriguez Rodriguez, A. Rogovskiy, D. L. Rolf, P. Roloff, V. Romanovskiy, M. Romero Lamas, A. Romero Vidal, G. Romolini, F. Ronchetti, T. Rong, M. Rotondo, S. R. Roy, M. S. Rudolph, T. Ruf, M. Ruiz Diaz, R. A. Ruiz Fernandez, J. Ruiz Vidal, A. Ryzhikov, J. Ryzka, J. J. Saavedra-Arias, J. J. Saborido Silva, R. Sadek, N. Sagidova, D. Sahoo, N. Sahoo, B. Saitta, M. Salomoni, C. Sanchez Gras, I. Sanderswood, R. Santacesaria, C. Santamarina Rios, M. Santimaria, L. Santoro, E. Santovetti, A. Saputi, D. Saranin, A. S. Sarnatskiy, G. Sarpis, M. Sarpis, C. Satriano, A. Satta, M. Saur, D. Savrina, H. Sazak, L. G. Scantlebury Smead, A. Scarabotto, S. Schael, S. Scherl, M. Schiller, H. Schindler, M. Schmelling, B. Schmidt, S. Schmitt, H. Schmitz, O. Schneider, A. Schopper, N. Schulte, S. Schulte, M. H. Schune, R. Schwemmer, G. Schwering, B. Sciascia, A. Sciuccati, S. Sellam, A. Semennikov, T. Senger, M. Senghi Soares, A. Sergi, N. Serra, L. Sestini, A. Seuthe, Y. Shang, D. M. Shangase, M. Shapkin, R. S. Sharma, I. Shchemerov, L. Shchutska, T. Shears, L. Shekhtman, Z. Shen, S. Sheng, V. Shevchenko, B. Shi, Q. Shi, Y. Shimizu, E. Shmanin, R. Shorkin, J. D. Shupperd, R. Silva Coutinho, G. Simi, S. Simone, N. Skidmore, T. Skwarnicki, M. W. Slater, J. C. Smallwood, E. Smith, K. Smith, M. Smith, A. Snoch, L. Soares Lavra, M. D. Sokoloff, F. J. P. Soler, A. Solomin, A. Solovev, I. Solovyev, R. Song, Y. Song, Y. S. Song, F. L. Souza De Almeida, B. Souza De Paula, E. Spadaro Norella, E. Spedicato, J. G. Speer, E. Spiridenkov, P. Spradlin, V. Sriskaran, F. Stagni, M. Stahl, S. Stahl, S. Stanislaus, E. N. Stein, O. Steinkamp, O. Stenyakin, H. Stevens, D. Strekalina, Y. Su, F. Suljik, J. Sun, L. Sun, Y. Sun, D. S. Sundfeld Lima, W. Sutcliffe, P. N. Swallow, F. Swystun, A. Szabelski, T. Szumlak, Y. Tan, M. D. Tat, A. Terentev, F. Terzuoli, F. Teubert, E. Thomas, D. J. D. Thompson, H. Tilquin, V. Tisserand, S. T’Jampens, M. Tobin, L. Tomassetti, G. Tonani, X. Tong, D. Torres Machado, L. Toscano, D. Y. Tou, C. Trippl, G. Tuci, N. Tuning, L. H. Uecker, A. Ukleja, D. J. Unverzagt, E. Ursov, A. Usachov, A. Ustyuzhanin, U. Uwer, V. Vagnoni, G. Valenti, N. Valls Canudas, H. Van Hecke, E. van Herwijnen, C. B. Van Hulse, R. Van Laak, M. van Veghel, G. Vasquez, R. Vazquez Gomez, P. Vazquez Regueiro, C. Vázquez Sierra, S. Vecchi, J. J. Velthuis, M. Veltri, A. Venkateswaran, M. Vesterinen, M. Vieites Diaz, X. Vilasis-Cardona, E. Vilella Figueras, A. Villa, P. Vincent, F. C. Volle, D. vom Bruch, N. Voropaev, K. Vos, G. Vouters, C. Vrahas, J. Wagner, J. Walsh, E. J. Walton, G. Wan, C. Wang, G. Wang, J. Wang, M. Wang, N. W. Wang, R. Wang, X. Wang, X. W. Wang, Y. Wang, Z. Wang, J. A. Ward, M. Waterlaat, N. K. Watson, D. Websdale, Y. Wei, J. Wendel, B. D. C. Westhenry, D. J. White, M. Whitehead, A. R. Wiederhold, D. Wiedner, G. Wilkinson, M. K. Wilkinson, M. Williams, M. R. J. Williams, R. Williams, F. F. Wilson, W. Wislicki, M. Witek, L. Witola, C. P. Wong, G. Wormser, S. A. Wotton, H. Wu, J. Wu, Y. Wu, K. Wyllie, S. Xian, Z. Xiang, Y. Xie, A. Xu, J. Xu, L. Xu, M. Xu, Z. Xu, D. Yang, K. Yang, S. Yang, X. Yang, Y. Yang, Z. Yang, V. Yeroshenko, H. Yeung, H. Yin, C. Y. Yu, J. Yu, X. Yuan, E. Zaffaroni, M. Zavertyaev, M. Zdybal, C. Zeng, M. Zeng, C. Zhang, D. Zhang, J. Zhang, L. Zhang, S. Zhang, Y. Zhang, Y. Z. Zhang, Y. Zhao, A. Zharkova, A. Zhelezov, S. Z. Zheng, X. Z. Zheng, Y. Zheng, T. Zhou, X. Zhou, Y. Zhou, V. Zhovkovska, L. Z. Zhu, X. Zhu, V. Zhukov, J. Zhuo, Q. Zou, D. Zuliani, and G. Zunica
Subjects: Fixed Target Experiments, Polarization, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract: Abstract A measurement of the transverse polarization of the Λ and Λ ¯ $$ \overline{\varLambda} $$ hyperons in pNe fixed-target collisions at s NN $$ \sqrt{{\textrm{s}}_{\textrm{NN}}} $$ = 68.4 GeV is presented using data collected by the LHCb detector. The polarization is studied using the decay Λ → pπ − together with its charge conjugated process, the integrated values measured are P Λ = 0.029 ± 0.019 stat ± 0.012 syst , P Λ ¯ = 0.003 ± 0.023 stat ± 0.014 syst . $$ {\displaystyle \begin{array}{c}{P}_{\varLambda }=0.029\pm 0.019\left(\textrm{stat}\right)\pm 0.012\left(\textrm{syst}\right),\\ {}{P}_{\overline{\varLambda}}=0.003\pm 0.023\left(\textrm{stat}\right)\pm 0.014\left(\textrm{syst}\right).\end{array}} $$ Furthermore, the results are shown as a function of the Feynman x variable, transverse momentum, pseudorapidity and rapidity of the hyperons, and are compared with previous measurements.
Published: 2024
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10. A research agenda to advance the study of implementation mechanisms

Author: Cara C. Lewis, Hannah E. Frank, Gracelyn Cruden, Bo Kim, Aubyn C. Stahmer, Aaron R. Lyon, Bianca Albers, Gregory A. Aarons, Rinad S. Beidas, Brian S. Mittman, Bryan J. Weiner, Nate J. Williams, Byron J. Powell, and MNoE Group
Subjects: Implementation science, Mechanisms, Mediators, Determinants, Implementation strategies, Methods, Medicine (General), R5-920
Abstract: Abstract Background Implementation science scholars have made significant progress identifying factors that enable or obstruct the implementation of evidence-based interventions, and testing strategies that may modify those factors. However, little research sheds light on how or why strategies work, in what contexts, and for whom. Studying implementation mechanisms—the processes responsible for change—is crucial for advancing the field of implementation science and enhancing its value in facilitating equitable policy and practice change. The Agency for Healthcare Research and Quality funded a conference series to achieve two aims: (1) develop a research agenda on implementation mechanisms, and (2) actively disseminate the research agenda to research, policy, and practice audiences. This article presents the resulting research agenda, including priorities and actions to encourage its execution. Method Building on prior concept mapping work, in a semi-structured, 3-day, in-person working meeting, 23 US-based researchers used a modified nominal group process to generate priorities and actions for addressing challenges to studying implementation mechanisms. During each of the three 120-min sessions, small groups responded to the prompt: “What actions need to be taken to move this research forward?” The groups brainstormed actions, which were then shared with the full group and discussed with the support of facilitators trained in structured group processes. Facilitators grouped critical and novel ideas into themes. Attendees voted on six themes they prioritized to discuss in a fourth, 120-min session, during which small groups operationalized prioritized actions. Subsequently, all ideas were collated, combined, and revised for clarity by a subset of the authorship team. Results From this multistep process, 150 actions emerged across 10 priority areas, which together constitute the research agenda. Actions included discrete activities, projects, or products, and ways to shift how research is conducted to strengthen the study of implementation mechanisms. Conclusions This research agenda elevates actions to guide the selection, design, and evaluation of implementation mechanisms. By delineating recommended actions to address the challenges of studying implementation mechanisms, this research agenda facilitates expanding the field of implementation science, beyond studying what works to how and why strategies work, in what contexts, for whom, and with which interventions.
Published: 2024
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11. The Adiabatic Evolution of 3D Annular Vortices with a Double-Eyewall Structure

Author: Gabriel J. Williams
Subjects: geophysical vortices, atmospheric dynamics, vortex Rossby waves, tropical cyclone dynamics, Thermodynamics, QC310.15-319, Biochemistry, QD415-436
Abstract: Tropical cyclones (TCs) can be characterized as a 3D annular structure of elevated potential vorticity (PV). However, strong mature TCs often develop a secondary eyewall, leading to a 3D annular vortex with a double-eyewall structure. Using 2D linear stability analysis, it is shown that three types of barotropic instability (BI) are present for annular vortices with a double-eyewall structure: Type-1 BI across the secondary eyewall, Type-2 BI across the moat of the vortex, and Type-3 BI across the primary eyewall. The overall stability of these vortices (and the type of BI that develops) depends principally upon five vortex parameters: the thickness of the primary eyewall, the thickness of the secondary eyewall, the moat width, the vorticity ratio between the eye and the primary eyewall, and the vorticity ratio between the primary and secondary eyewall. The adiabatic evolution of 3D annular vortices with a double-eyewall structure is examined using a primitive equation model in normalized isobaric coordinates. It is shown that Type-2 BI is the most common type of BI for 3D annular vortices whose vortex parameters mimic TCs with a double-eyewall structure. During the onset of Type-2 BI, eddy kinetic energy budget analysis indicates that barotropic energy conversion from the mean azimuthal flow is the dominant energy source of the eddies, which produces a radial velocity field with a quadrupole structure. Absolute angular momentum budget analysis indicates that Type-2 BI generates azimuthally averaged radial outflow across the moat, and the eddies transport absolute angular momentum radially outward towards the secondary eyewall. The combination of these processes leads to the dissipation of the primary eyewall and the maintenance of the secondary eyewall for the vortex.
Published: 2024
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12. Comprehensive analysis of local and nonlocal amplitudes in the B 0 → K *0 μ + μ − decay

Author: The LHCb collaboration, R. Aaij, A. S. W. Abdelmotteleb, C. Abellan Beteta, F. Abudinén, T. Ackernley, A. A. Adefisoye, B. Adeva, M. Adinolfi, P. Adlarson, C. Agapopoulou, C. A. Aidala, Z. Ajaltouni, S. Akar, K. Akiba, P. Albicocco, J. Albrecht, F. Alessio, M. Alexander, Z. Aliouche, P. Alvarez Cartelle, R. Amalric, S. Amato, J. L. Amey, Y. Amhis, L. An, L. Anderlini, M. Andersson, A. Andreianov, P. Andreola, M. Andreotti, D. Andreou, A. Anelli, D. Ao, F. Archilli, M. Argenton, S. Arguedas Cuendis, A. Artamonov, M. Artuso, E. Aslanides, R. Ataide Da Silva, M. Atzeni, B. Audurier, D. Bacher, I. Bachiller Perea, S. Bachmann, M. Bachmayer, J. J. Back, P. Baladron Rodriguez, V. Balagura, W. Baldini, H. Bao, J. Baptista de Souza Leite, M. Barbetti, I. R. Barbosa, R. J. Barlow, M. Barnyakov, S. Barsuk, W. Barter, M. Bartolini, J. Bartz, J. M. Basels, G. Bassi, B. Batsukh, A. Bay, A. Beck, M. Becker, F. Bedeschi, I. B. Bediaga, S. Belin, V. Bellee, K. Belous, I. Belov, I. Belyaev, G. Benane, G. Bencivenni, E. Ben-Haim, A. Berezhnoy, R. Bernet, S. Bernet Andres, A. Bertolin, C. Betancourt, F. Betti, J. Bex, Ia. Bezshyiko, J. Bhom, M. S. Bieker, N. V. Biesuz, P. Billoir, A. Biolchini, M. Birch, F. C. R. Bishop, A. Bitadze, A. Bizzeti, T. Blake, F. Blanc, J. E. Blank, S. Blusk, V. Bocharnikov, J. A. Boelhauve, O. Boente Garcia, T. Boettcher, A. Bohare, A. Boldyrev, C. S. Bolognani, R. Bolzonella, N. Bondar, F. Borgato, S. Borghi, M. Borsato, J. T. Borsuk, S. A. Bouchiba, T. J. V. Bowcock, A. Boyer, C. Bozzi, A. Brea Rodriguez, N. Breer, J. Brodzicka, A. Brossa Gonzalo, J. Brown, D. Brundu, E. Buchanan, A. Buonaura, L. Buonincontri, A. T. Burke, C. Burr, A. Butkevich, J. S. Butter, J. Buytaert, W. Byczynski, S. Cadeddu, H. Cai, R. Calabrese, S. Calderon Ramirez, L. Calefice, S. Cali, M. Calvi, M. Calvo Gomez, P. Camargo Magalhaes, J. I. Cambon Bouzas, P. Campana, D. H. Campora Perez, A. F. Campoverde Quezada, S. Capelli, L. Capriotti, R. Caravaca-Mora, A. Carbone, L. Carcedo Salgado, R. Cardinale, A. Cardini, P. Carniti, L. Carus, A. Casais Vidal, R. Caspary, G. Casse, J. Castro Godinez, M. Cattaneo, G. Cavallero, V. Cavallini, S. Celani, D. Cervenkov, S. Cesare, A. J. Chadwick, I. Chahrour, M. Charles, Ph. Charpentier, E. Chatzianagnostou, C. A. Chavez Barajas, M. Chefdeville, C. Chen, S. Chen, Z. Chen, A. Chernov, S. Chernyshenko, V. Chobanova, S. Cholak, M. Chrzaszcz, A. Chubykin, V. Chulikov, P. Ciambrone, X. Cid Vidal, G. Ciezarek, P. Cifra, P. E. L. Clarke, M. Clemencic, H. V. Cliff, J. Closier, C. Cocha Toapaxi, V. Coco, J. Cogan, E. Cogneras, L. Cojocariu, P. Collins, T. Colombo, A. Comerma-Montells, L. Congedo, A. Contu, N. Cooke, I. Corredoira, A. Correia, G. Corti, J. J. Cottee Meldrum, B. Couturier, D. C. Craik, M. Cruz Torres, E. Curras Rivera, R. Currie, C. L. Da Silva, S. Dadabaev, L. Dai, X. Dai, E. Dall’Occo, J. Dalseno, C. D’Ambrosio, J. Daniel, A. Danilina, P. d’Argent, A. Davidson, J. E. Davies, A. Davis, O. De Aguiar Francisco, C. De Angelis, F. De Benedetti, J. de Boer, K. De Bruyn, S. De Capua, M. De Cian, U. De Freitas Carneiro Da Graca, E. De Lucia, J. M. De Miranda, L. De Paula, M. De Serio, P. De Simone, F. De Vellis, J. A. de Vries, F. Debernardis, D. Decamp, V. Dedu, L. Del Buono, B. Delaney, H.-P. Dembinski, J. Deng, V. Denysenko, O. Deschamps, F. Dettori, B. Dey, P. Di Nezza, I. Diachkov, S. Didenko, S. Ding, L. Dittmann, V. Dobishuk, A. D. Docheva, C. Dong, A. M. Donohoe, F. Dordei, A. C. dos Reis, A. D. Dowling, W. Duan, P. Duda, M. W. Dudek, L. Dufour, V. Duk, P. Durante, M. M. Duras, J. M. Durham, O. D. Durmus, A. Dziurda, A. Dzyuba, S. Easo, E. Eckstein, U. Egede, A. Egorychev, V. Egorychev, S. Eisenhardt, E. Ejopu, L. Eklund, M. Elashri, J. Ellbracht, S. Ely, A. Ene, E. Epple, J. Eschle, S. Esen, T. Evans, F. Fabiano, L. N. Falcao, Y. Fan, B. Fang, L. Fantini, M. Faria, K. Farmer, D. Fazzini, L. Felkowski, M. Feng, M. Feo, M. Fernandez Gomez, A. D. Fernez, F. Ferrari, F. Ferreira Rodrigues, M. Ferrillo, M. Ferro-Luzzi, S. Filippov, R. A. Fini, M. Fiorini, K. M. Fischer, D. S. Fitzgerald, C. Fitzpatrick, F. Fleuret, M. Fontana, L. F. Foreman, R. Forty, D. Foulds-Holt, M. Franco Sevilla, M. Frank, E. Franzoso, G. Frau, C. Frei, D. A. Friday, J. Fu, Q. Fuehring, Y. Fujii, T. Fulghesu, E. Gabriel, G. Galati, M. D. Galati, A. Gallas Torreira, D. Galli, S. Gambetta, M. Gandelman, P. Gandini, B. Ganie, H. Gao, R. Gao, Y. Gao, M. Garau, L. M. Garcia Martin, P. Garcia Moreno, J. García Pardiñas, K. G. Garg, L. Garrido, C. Gaspar, R. E. Geertsema, L. L. Gerken, E. Gersabeck, M. Gersabeck, T. Gershon, Z. Ghorbanimoghaddam, L. Giambastiani, F. I. Giasemis, V. Gibson, H. K. Giemza, A. L. Gilman, M. Giovannetti, A. Gioventù, P. Gironella Gironell, C. Giugliano, M. A. Giza, E. L. Gkougkousis, F. C. Glaser, V. V. Gligorov, C. Göbel, E. Golobardes, D. Golubkov, A. Golutvin, A. Gomes, S. Gomez Fernandez, F. Goncalves Abrantes, M. Goncerz, G. Gong, J. A. Gooding, I. V. Gorelov, C. Gotti, J. P. Grabowski, L. A. Granado Cardoso, E. Graugés, E. Graverini, L. Grazette, G. Graziani, A. T. Grecu, L. M. Greeven, N. A. Grieser, L. Grillo, S. Gromov, C. Gu, M. Guarise, M. Guittiere, V. Guliaeva, P. A. Günther, A.-K. Guseinov, E. Gushchin, Y. Guz, T. Gys, K. Habermann, T. Hadavizadeh, C. Hadjivasiliou, G. Haefeli, C. Haen, J. Haimberger, M. Hajheidari, M. M. Halvorsen, P. M. Hamilton, J. Hammerich, Q. Han, X. Han, S. Hansmann-Menzemer, L. Hao, N. Harnew, M. Hartmann, J. He, M. Hecker, F. Hemmer, C. Henderson, R. D. L. Henderson, A. M. Hennequin, K. Hennessy, L. Henry, J. Herd, P. Herrero Gascon, J. Heuel, A. Hicheur, G. Hijano Mendizabal, D. Hill, S. E. Hollitt, J. Horswill, R. Hou, Y. Hou, N. Howarth, J. Hu, W. Hu, X. Hu, W. Huang, W. Hulsbergen, R. J. Hunter, M. Hushchyn, D. Hutchcroft, D. Ilin, P. Ilten, A. Inglessi, A. Iniukhin, A. Ishteev, K. Ivshin, R. Jacobsson, H. Jage, S. J. Jaimes Elles, S. Jakobsen, E. Jans, B. K. Jashal, A. Jawahery, V. Jevtic, E. Jiang, X. Jiang, Y. Jiang, Y. J. Jiang, M. John, D. Johnson, C. R. Jones, T. P. Jones, S. Joshi, B. Jost, N. Jurik, I. Juszczak, D. Kaminaris, S. Kandybei, M. Kane, Y. Kang, C. Kar, M. Karacson, D. Karpenkov, A. Kauniskangas, J. W. Kautz, F. Keizer, M. Kenzie, T. Ketel, B. Khanji, A. Kharisova, S. Kholodenko, G. Khreich, T. Kirn, V. S. Kirsebom, O. Kitouni, S. Klaver, N. Kleijne, K. Klimaszewski, M. R. Kmiec, S. Koliiev, L. Kolk, A. Konoplyannikov, P. Kopciewicz, P. Koppenburg, M. Korolev, I. Kostiuk, O. Kot, S. Kotriakhova, A. Kozachuk, P. Kravchenko, L. Kravchuk, M. Kreps, P. Krokovny, W. Krupa, W. Krzemien, O. K. Kshyvanskyi, J. Kubat, S. Kubis, M. Kucharczyk, V. Kudryavtsev, E. Kulikova, A. Kupsc, B. K. Kutsenko, D. Lacarrere, A. Lai, A. Lampis, D. Lancierini, C. Landesa Gomez, J. J. Lane, R. Lane, C. Langenbruch, J. Langer, O. Lantwin, T. Latham, F. Lazzari, C. Lazzeroni, R. Le Gac, R. Lefèvre, A. Leflat, S. Legotin, M. Lehuraux, E. Lemos Cid, O. Leroy, T. Lesiak, B. Leverington, A. Li, H. Li, K. Li, L. Li, P. Li, P.-R. Li, Q. Li, S. Li, T. Li, Y. Li, Z. Lian, X. Liang, S. Libralon, C. Lin, T. Lin, R. Lindner, V. Lisovskyi, R. Litvinov, F. L. Liu, G. Liu, K. Liu, S. Liu, Y. Liu, Y. L. Liu, A. Lobo Salvia, A. Loi, J. Lomba Castro, T. Long, J. H. Lopes, A. Lopez Huertas, S. López Soliño, C. Lucarelli, D. Lucchesi, M. Lucio Martinez, V. Lukashenko, Y. Luo, A. Lupato, E. Luppi, K. Lynch, X.-R. Lyu, G. M. Ma, R. Ma, S. Maccolini, F. Machefert, F. Maciuc, B. Mack, I. Mackay, L. M. Mackey, L. R. Madhan Mohan, M. J. Madurai, A. Maevskiy, D. Magdalinski, D. Maisuzenko, M. W. Majewski, J. J. Malczewski, S. Malde, L. Malentacca, A. Malinin, T. Maltsev, G. Manca, G. Mancinelli, C. Mancuso, R. Manera Escalero, D. Manuzzi, D. Marangotto, J. F. Marchand, R. Marchevski, U. Marconi, S. Mariani, C. Marin Benito, J. Marks, A. M. Marshall, G. Martelli, G. Martellotti, L. Martinazzoli, M. Martinelli, D. Martinez Santos, F. Martinez Vidal, A. Massafferri, R. Matev, A. Mathad, V. Matiunin, C. Matteuzzi, K. R. Mattioli, A. Mauri, E. Maurice, J. Mauricio, P. Mayencourt, M. Mazurek, M. McCann, L. Mcconnell, T. H. McGrath, N. T. McHugh, A. McNab, R. McNulty, B. Meadows, G. Meier, D. Melnychuk, F. M. Meng, M. Merk, A. Merli, L. Meyer Garcia, D. Miao, H. Miao, M. Mikhasenko, D. A. Milanes, A. Minotti, E. Minucci, T. Miralles, B. Mitreska, D. S. Mitzel, A. Modak, A. Mödden, R. A. Mohammed, R. D. Moise, S. Mokhnenko, T. Mombächer, M. Monk, S. Monteil, A. Morcillo Gomez, G. Morello, M. J. Morello, M. P. Morgenthaler, A. B. Morris, A. G. Morris, R. Mountain, H. Mu, Z. M. Mu, E. Muhammad, F. Muheim, M. Mulder, K. Müller, F. Muñoz-Rojas, R. Murta, P. Naik, T. Nakada, R. Nandakumar, T. Nanut, I. Nasteva, M. Needham, N. Neri, S. Neubert, N. Neufeld, P. Neustroev, J. Nicolini, D. Nicotra, E. M. Niel, N. Nikitin, P. Nogarolli, P. Nogga, N. S. Nolte, C. Normand, J. Novoa Fernandez, G. Nowak, C. Nunez, H. N. Nur, A. Oblakowska-Mucha, V. Obraztsov, T. Oeser, S. Okamura, A. Okhotnikov, O. Okhrimenko, R. Oldeman, F. Oliva, M. Olocco, C. J. G. Onderwater, R. H. O’Neil, J. M. Otalora Goicochea, P. Owen, A. Oyanguren, O. Ozcelik, A. Padee, K. O. Padeken, B. Pagare, P. R. Pais, T. Pajero, A. Palano, M. Palutan, G. Panshin, L. Paolucci, A. Papanestis, M. Pappagallo, L. L. Pappalardo, C. Pappenheimer, C. Parkes, B. Passalacqua, G. Passaleva, D. Passaro, A. Pastore, M. Patel, J. Patoc, C. Patrignani, A. Paul, C. J. Pawley, A. Pellegrino, J. Peng, M. Pepe Altarelli, S. Perazzini, D. Pereima, H. Pereira Da Costa, A. Pereiro Castro, P. Perret, A. Perro, K. Petridis, A. Petrolini, J. P. Pfaller, H. Pham, L. Pica, M. Piccini, B. Pietrzyk, G. Pietrzyk, D. Pinci, F. Pisani, M. Pizzichemi, V. Placinta, M. Plo Casasus, F. Polci, M. Poli Lener, A. Poluektov, N. Polukhina, I. Polyakov, E. Polycarpo, G. J. Pomery, S. Ponce, D. Popov, S. Poslavskii, K. Prasanth, C. Prouve, V. Pugatch, G. Punzi, S. Qasim, Q. Q. Qian, W. Qian, N. Qin, S. Qu, R. Quagliani, R. I. Rabadan Trejo, J. H. Rademacker, M. Rama, M. Ramírez García, V. Ramos De Oliveira, M. Ramos Pernas, M. S. Rangel, F. Ratnikov, G. Raven, M. Rebollo De Miguel, F. Redi, J. Reich, F. Reiss, Z. Ren, P. K. Resmi, R. Ribatti, G. R. Ricart, D. Riccardi, S. Ricciardi, K. Richardson, M. Richardson-Slipper, K. Rinnert, P. Robbe, G. Robertson, E. Rodrigues, E. Rodriguez Fernandez, J. A. Rodriguez Lopez, E. Rodriguez Rodriguez, A. Rogovskiy, D. L. Rolf, P. Roloff, V. Romanovskiy, M. Romero Lamas, A. Romero Vidal, G. Romolini, F. Ronchetti, T. Rong, M. Rotondo, S. R. Roy, M. S. Rudolph, T. Ruf, M. Ruiz Diaz, R. A. Ruiz Fernandez, J. Ruiz Vidal, A. Ryzhikov, J. Ryzka, J. J. Saavedra-Arias, J. J. Saborido Silva, R. Sadek, N. Sagidova, D. Sahoo, N. Sahoo, B. Saitta, M. Salomoni, C. Sanchez Gras, I. Sanderswood, R. Santacesaria, C. Santamarina Rios, M. Santimaria, L. Santoro, E. Santovetti, A. Saputi, D. Saranin, A. S. Sarnatskiy, G. Sarpis, M. Sarpis, C. Satriano, A. Satta, M. Saur, D. Savrina, H. Sazak, L. G. Scantlebury Smead, A. Scarabotto, S. Schael, S. Scherl, M. Schiller, H. Schindler, M. Schmelling, B. Schmidt, S. Schmitt, H. Schmitz, O. Schneider, A. Schopper, N. Schulte, S. Schulte, M. H. Schune, R. Schwemmer, G. Schwering, B. Sciascia, A. Sciuccati, S. Sellam, A. Semennikov, T. Senger, M. Senghi Soares, A. Sergi, N. Serra, L. Sestini, A. Seuthe, Y. Shang, D. M. Shangase, M. Shapkin, R. S. Sharma, I. Shchemerov, L. Shchutska, T. Shears, L. Shekhtman, Z. Shen, S. Sheng, V. Shevchenko, B. Shi, Q. Shi, Y. Shimizu, E. Shmanin, R. Shorkin, J. D. Shupperd, R. Silva Coutinho, G. Simi, S. Simone, N. Skidmore, T. Skwarnicki, M. W. Slater, J. C. Smallwood, E. Smith, K. Smith, M. Smith, A. Snoch, L. Soares Lavra, M. D. Sokoloff, F. J. P. Soler, A. Solomin, A. Solovev, I. Solovyev, R. Song, Y. Song, Y. S. Song, F. L. Souza De Almeida, B. Souza De Paula, E. Spadaro Norella, E. Spedicato, J. G. Speer, E. Spiridenkov, P. Spradlin, V. Sriskaran, F. Stagni, M. Stahl, S. Stahl, S. Stanislaus, E. N. Stein, O. Steinkamp, O. Stenyakin, H. Stevens, D. Strekalina, Y. Su, F. Suljik, J. Sun, L. Sun, Y. Sun, D. S. Sundfeld Lima, W. Sutcliffe, P. N. Swallow, F. Swystun, A. Szabelski, T. Szumlak, Y. Tan, M. D. Tat, A. Terentev, F. Terzuoli, F. Teubert, E. Thomas, D. J. D. Thompson, H. Tilquin, V. Tisserand, S. T’Jampens, M. Tobin, L. Tomassetti, G. Tonani, X. Tong, D. Torres Machado, L. Toscano, D. Y. Tou, C. Trippl, G. Tuci, N. Tuning, L. H. Uecker, A. Ukleja, D. J. Unverzagt, E. Ursov, A. Usachov, A. Ustyuzhanin, U. Uwer, V. Vagnoni, G. Valenti, N. Valls Canudas, H. Van Hecke, E. van Herwijnen, C. B. Van Hulse, R. Van Laak, M. van Veghel, G. Vasquez, R. Vazquez Gomez, P. Vazquez Regueiro, C. Vázquez Sierra, S. Vecchi, J. J. Velthuis, M. Veltri, A. Venkateswaran, M. Vesterinen, M. Vieites Diaz, X. Vilasis-Cardona, E. Vilella Figueras, A. Villa, P. Vincent, F. C. Volle, D. vom Bruch, N. Voropaev, K. Vos, G. Vouters, C. Vrahas, J. Wagner, J. Walsh, E. J. Walton, G. Wan, C. Wang, G. Wang, J. Wang, M. Wang, N. W. Wang, R. Wang, X. Wang, X. W. Wang, Y. Wang, Z. Wang, J. A. Ward, M. Waterlaat, N. K. Watson, D. Websdale, Y. Wei, J. Wendel, B. D. C. Westhenry, D. J. White, M. Whitehead, E. Whiter, A. R. Wiederhold, D. Wiedner, G. Wilkinson, M. K. Wilkinson, M. Williams, M. R. J. Williams, R. Williams, F. F. Wilson, W. Wislicki, M. Witek, L. Witola, C. P. Wong, G. Wormser, S. A. Wotton, H. Wu, J. Wu, Y. Wu, K. Wyllie, S. Xian, Z. Xiang, Y. Xie, A. Xu, J. Xu, L. Xu, M. Xu, Z. Xu, D. Yang, K. Yang, S. Yang, X. Yang, Y. Yang, Z. Yang, V. Yeroshenko, H. Yeung, H. Yin, C. Y. Yu, J. Yu, X. Yuan, E. Zaffaroni, M. Zavertyaev, M. Zdybal, C. Zeng, M. Zeng, C. Zhang, D. Zhang, J. Zhang, L. Zhang, S. Zhang, Y. Zhang, Y. Z. Zhang, Y. Zhao, A. Zharkova, A. Zhelezov, S. Z. Zheng, X. Z. Zheng, Y. Zheng, T. Zhou, X. Zhou, Y. Zhou, V. Zhovkovska, L. Z. Zhu, X. Zhu, V. Zhukov, J. Zhuo, Q. Zou, D. Zuliani, and G. Zunica
Subjects: B Physics, Flavour Changing Neutral Currents, Flavour Physics, Hadron-Hadron Scattering, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract: Abstract A comprehensive study of the local and nonlocal amplitudes contributing to the decay B 0 → K *0(→ K + π − )μ + μ − is performed by analysing the phase-space distribution of the decay products. The analysis is based on pp collision data corresponding to an integrated luminosity of 8.4 fb −1 collected by the LHCb experiment. This measurement employs for the first time a model of both one-particle and two-particle nonlocal amplitudes, and utilises the complete dimuon mass spectrum without any veto regions around the narrow charmonium resonances. In this way it is possible to explicitly isolate the local and nonlocal contributions and capture the interference between them. The results show that interference with nonlocal contributions, although larger than predicted, only has a minor impact on the Wilson Coefficients determined from the fit to the data. For the local contributions, the Wilson Coefficient C 9 $$ {\mathcal{C}}_9 $$ , responsible for vector dimuon currents, exhibits a 2.1σ deviation from the Standard Model expectation. The Wilson Coefficients C 10 $$ {\mathcal{C}}_{10} $$ , C 9 ′ $$ {\mathcal{C}}_9^{\prime } $$ and C 10 ′ $$ {\mathcal{C}}_{10}^{\prime } $$ are all in better agreement than C 9 $$ {\mathcal{C}}_9 $$ with the Standard Model and the global significance is at the level of 1.5σ. The model used also accounts for nonlocal contributions from B 0 → K *0[τ + τ − → μ + μ − ] rescattering, resulting in the first direct measurement of the bsττ vector effective-coupling C 9 τ $$ {\mathcal{C}}_{9\tau } $$ .
Published: 2024
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13. The tales of two cities: use of evidence for introducing 20 miles per hour speed limits in Edinburgh and Belfast (United Kingdom)

Author: Karen Milton, Graham Baker, Claire L. Cleland, Andy Cope, Ruth F. Hunter, Ruth Jepson, Frank Kee, Paul Kelly, Andrew J. Williams, and Michael P. Kelly
Subjects: 20 mph, Speed limit, Evidence, Policy, Public aspects of medicine, RA1-1270
Abstract: Abstract Background In 2016, large-scale 20 miles per hour speed limits were introduced in the United Kingdom cities of Edinburgh and Belfast. This paper investigates the role that scientific evidence played in the policy decisions to implement lower speed limits in the two cities. Methods Using a qualitative case study design, we undertook content analysis of a range of documents to explore and describe the evolution of the two schemes and the ways in which evidence informed decision-making. In total, we identified 16 documents for Edinburgh, published between 2006 and 2016, and 19 documents for Belfast, published between 2002 and 2016. Findings In both cities, evidence on speed, collisions and casualties was important for initiating discussions on large-scale 20 mph policies. However, the narrative shifted over time to the idea that 20 mph would contribute to a wider range of aspirations, none of which were firmly grounded in evidence, but may have helped to neutralize opposing discourses. Discussion and conclusions The relationship between evidence and decision-making in Edinburgh and Belfast was neither simple nor linear. Widening of the narrative appears to have helped to frame the idea in such a way that it had broad acceptability, without which there would have been no implementation, and probably a lot more push back from vested interests and communities than there was.
Published: 2024
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14. Determining meaningful thresholds for evaluating treatment efficacy in patients with alopecia areata

Author: Ernest H. Law, Nicole J. Williams, Dane Korver, Randall H. Bender, Debanjali Mitra, Gregor Schaefer, and Lauren M. Nelson
Subjects: alopecia areata, hair loss, meaningful change, patient‐reported outcomes, SALT, Dermatology, RL1-803, Diseases of the genitourinary system. Urology, RC870-923
Abstract: Abstract Background The Severity of Alopecia Tool (SALT) is a clinician‐reported outcome measure of scalp hair loss in alopecia areata (AA). Objectives To characterise the magnitudes of change in SALT scores corresponding to meaningful treatment benefits from the patient's perspective. Methods Anchor‐based methods for the estimation of meaningful within‐patient change thresholds were applied to pooled data from a randomised, double‐blind trial of ritlecitinib. Anchors included a patient‐reported measure of change in AA severity, the Patient Global Impression of Change (PGI‐C) and three items comprising the Patient Satisfaction with Hair Growth (P‐Sat) questionnaire. After reviewing Pearson correlations between change‐from‐baseline SALT scores and each anchor to confirm adequate association, potential thresholds were computed as mean change‐from‐baseline SALT scores among patients who reported moderate improvement on the PGI‐C and/or moderate satisfaction on each of three P‐Sat items at week 24. Results Six hundred and fifty participants (86% adults, 14% adolescents) had mean (standard deviation) SALT scores of 90.6 (14.3) at baseline, suggesting a sample with primarily severe AA. Correlations between SALT change‐from‐baseline scores and the patient‐reported items supported their use as anchors. Estimates based on patients reporting moderate improvement in AA (n = 102) on the PGI‐C and those reporting moderate satisfaction on the P‐Sat item related to the amount of hair growth at week 24 (n = 122) were −42.2 (26.1) and −43.1 (26.8), respectively. Supportive estimates based on the remaining P‐Sat items were similar in magnitude. Conclusions Among patients with severe AA, SALT change‐from‐baseline scores of 42 or 43 represent meaningful improvements. While the achievement of low SALT scores of ≤10–≤20 have been used to characterise efficacy in clinical trials, the amount of change required to meet this endpoint far exceeds the estimates in this study. The treatment goals of individual patients must be considered when evaluating benefit in both clinical trials and clinical practice.
Published: 2024
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15. 'Neural Noise' in Auditory Responses in Young Autistic and Neurotypical Children

Author: Patrick Dwyer, Svjetlana Vukusic, Zachary J. Williams, Clifford D. Saron, and Susan M. Rivera
Abstract: Elevated "neural noise" has been advanced as an explanation of autism and autistic sensory experiences. However, functional neuroimaging measures of neural noise may be vulnerable to contamination by recording noise. This study explored variability of electrophysiological responses to tones of different intensities in 127 autistic and 79 typically-developing children aged 2-5 years old. A rigorous data processing pipeline, including advanced visualizations of different signal sources that were maximally independent across different time lags, was used to identify and eliminate putative recording noise. Inter-trial variability was measured using median absolute deviations (MADs) of EEG amplitudes across trials and inter-trial phase coherence (ITPC). ITPC was elevated in autism in the 50 and 60 dB intensity conditions, suggesting diminished (rather than elevated) neural noise in autism, although reduced ITPC to soft 50 dB sounds was associated with increased loudness discomfort. Autistic and non-autistic participants did not differ in MADs, and indeed, the vast majority of the statistical tests examined in this study yielded no significant effects. These results appear inconsistent with the neural noise account.
Published: 2024
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16. Social Validity of Pivotal Response Treatment for Young Autistic Children: Perspectives of Autistic Adults

Author: Rachel K. Schuck, Patrick Dwyer, Kaitlynn M. P. Baiden, Zachary J. Williams, and Mian Wang
Abstract: The social validity of autism behavioral intervention has been questioned. Naturalistic Developmental Behavioral Interventions (NDBIs) attempt to address some concerns, but it is unclear whether autistic people consider NDBIs socially valid. Social validity of an NDBI, Pivotal Response Treatment (PRT), was investigated through autistic adults commenting on videos of autistic children receiving PRT. Qualitative coding of responses generated three themes: respect for individuals; assessment of intervention implementation; and socioemotional considerations. Although video brevity limits the scope of the present study's conclusions, participants highlighted PRT components that appeared socially valid (e.g., reinforcing attempts, following the child's lead) and aspects appearing invalid (e.g., overemphasis on spoken language). Therefore, adjustments appear necessary for PRT to be fully acceptable to the autistic community.
Published: 2024
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17. The Role of Accuracy in Children's Judgments of Experts' Knowledge

Author: Allison J. Williams and Judith H. Danovitch
Abstract: Across two studies, children ages 6-9 (N = 160, 82 boys, 78 girls; 75% White, 91% non-Hispanic) rated an inaccurate expert's knowledge and provided explanations for the expert's inaccurate statements. In Study 1, children's knowledge ratings decreased as he provided more inaccurate information. Ratings were predicted by age (i.e., older children gave lower ratings than younger children) and how children explained the error. Children's ratings followed similar patterns in Study 2. However, children delegated new questions to the inaccurate expert, even after rating him as having little to no knowledge. These results suggest that 6- to 9-year-olds weigh accuracy over expertise when making epistemic judgments, but, when they need assistance, they will still seek out information from a previously inaccurate expert.
Published: 2024
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18. Amplitude analysis and branching fraction measurement of B + → D ∗ − D s + π + $$ {B}^{+}\to {D}^{\ast -}{D}_s^{+}{\pi}^{+} $$ decays

Author: The LHCb collaboration, R. Aaij, A. S. W. Abdelmotteleb, C. Abellan Beteta, F. Abudinén, T. Ackernley, J. A. Adams, A. A. Adefisoye, B. Adeva, M. Adinolfi, P. Adlarson, C. Agapopoulou, C. A. Aidala, Z. Ajaltouni, S. Akar, K. Akiba, P. Albicocco, J. Albrecht, F. Alessio, M. Alexander, Z. Aliouche, P. Alvarez Cartelle, R. Amalric, S. Amato, J. L. Amey, Y. Amhis, L. An, L. Anderlini, M. Andersson, A. Andreianov, P. Andreola, M. Andreotti, D. Andreou, A. Anelli, D. Ao, F. Archilli, M. Argenton, S. Arguedas Cuendis, A. Artamonov, M. Artuso, E. Aslanides, M. Atzeni, B. Audurier, D. Bacher, I. Bachiller Perea, S. Bachmann, M. Bachmayer, J. J. Back, P. Baladron Rodriguez, V. Balagura, W. Baldini, H. Bao, J. Baptista de Souza Leite, M. Barbetti, I. R. Barbosa, R. J. Barlow, M. Barnyakov, S. Barsuk, W. Barter, M. Bartolini, J. Bartz, F. Baryshnikov, J. M. Basels, G. Bassi, B. Batsukh, A. Battig, A. Bay, A. Beck, M. Becker, F. Bedeschi, I. B. Bediaga, S. Belin, V. Bellee, K. Belous, I. Belov, I. Belyaev, G. Benane, G. Bencivenni, E. Ben-Haim, A. Berezhnoy, R. Bernet, S. Bernet Andres, A. Bertolin, C. Betancourt, F. Betti, J. Bex, Ia. Bezshyiko, J. Bhom, M. S. Bieker, N. V. Biesuz, P. Billoir, A. Biolchini, M. Birch, F. C. R. Bishop, A. Bitadze, A. Bizzeti, T. Blake, F. Blanc, J. E. Blank, S. Blusk, V. Bocharnikov, J. A. Boelhauve, O. Boente Garcia, T. Boettcher, A. Bohare, A. Boldyrev, C. S. Bolognani, R. Bolzonella, N. Bondar, F. Borgato, S. Borghi, M. Borsato, J. T. Borsuk, S. A. Bouchiba, T. J. V. Bowcock, A. Boyer, C. Bozzi, M. J. Bradley, A. Brea Rodriguez, N. Breer, J. Brodzicka, A. Brossa Gonzalo, J. Brown, D. Brundu, E. Buchanan, A. Buonaura, L. Buonincontri, A. T. Burke, C. Burr, A. Butkevich, J. S. Butter, J. Buytaert, W. Byczynski, S. Cadeddu, H. Cai, R. Calabrese, S. Calderon Ramirez, L. Calefice, S. Cali, M. Calvi, M. Calvo Gomez, J. Cambon Bouzas, P. Campana, D. H. Campora Perez, A. F. Campoverde Quezada, S. Capelli, L. Capriotti, R. Caravaca-Mora, A. Carbone, L. Carcedo Salgado, R. Cardinale, A. Cardini, P. Carniti, L. Carus, A. Casais Vidal, R. Caspary, G. Casse, J. Castro Godinez, M. Cattaneo, G. Cavallero, V. Cavallini, S. Celani, D. Cervenkov, S. Cesare, A. J. Chadwick, I. Chahrour, M. Charles, Ph. Charpentier, C. A. Chavez Barajas, M. Chefdeville, C. Chen, S. Chen, Z. Chen, A. Chernov, S. Chernyshenko, V. Chobanova, S. Cholak, M. Chrzaszcz, A. Chubykin, V. Chulikov, P. Ciambrone, X. Cid Vidal, G. Ciezarek, P. Cifra, P. E. L. Clarke, M. Clemencic, H. V. Cliff, J. Closier, C. Cocha Toapaxi, V. Coco, J. Cogan, E. Cogneras, L. Cojocariu, P. Collins, T. Colombo, A. Comerma-Montells, L. Congedo, A. Contu, N. Cooke, I. Corredoira, A. Correia, G. Corti, J. J. Cottee Meldrum, B. Couturier, D. C. Craik, M. Cruz Torres, E. Curras Rivera, R. Currie, C. L. Da Silva, S. Dadabaev, L. Dai, X. Dai, E. Dall’Occo, J. Dalseno, C. D’Ambrosio, J. Daniel, A. Danilina, P. d’Argent, A. Davidson, J. E. Davies, A. Davis, O. De Aguiar Francisco, C. De Angelis, J. de Boer, K. De Bruyn, S. De Capua, M. De Cian, U. De Freitas Carneiro Da Graca, E. De Lucia, J. M. De Miranda, L. De Paula, M. De Serio, P. De Simone, F. De Vellis, J. A. de Vries, F. Debernardis, D. Decamp, V. Dedu, L. Del Buono, B. Delaney, H.-P. Dembinski, J. Deng, V. Denysenko, O. Deschamps, F. Dettori, B. Dey, P. Di Nezza, I. Diachkov, S. Didenko, S. Ding, L. Dittmann, V. Dobishuk, A. D. Docheva, C. Dong, A. M. Donohoe, F. Dordei, A. C. dos Reis, A. D. Dowling, W. Duan, P. Duda, M. W. Dudek, L. Dufour, V. Duk, P. Durante, M. M. Duras, J. M. Durham, O. D. Durmus, A. Dziurda, A. Dzyuba, S. Easo, E. Eckstein, U. Egede, A. Egorychev, V. Egorychev, S. Eisenhardt, E. Ejopu, S. Ek-In, L. Eklund, M. Elashri, J. Ellbracht, S. Ely, A. Ene, E. Epple, J. Eschle, S. Esen, T. Evans, F. Fabiano, L. N. Falcao, Y. Fan, B. Fang, L. Fantini, M. Faria, K. Farmer, D. Fazzini, L. Felkowski, M. Feng, M. Feo, M. Fernandez Gomez, A. D. Fernez, F. Ferrari, F. Ferreira Rodrigues, S. Ferreres Sole, M. Ferrillo, M. Ferro-Luzzi, S. Filippov, R. A. Fini, M. Fiorini, K. M. Fischer, D. S. Fitzgerald, C. Fitzpatrick, F. Fleuret, M. Fontana, L. F. Foreman, R. Forty, D. Foulds-Holt, M. Franco Sevilla, M. Frank, E. Franzoso, G. Frau, C. Frei, D. A. Friday, J. Fu, Q. Fuehring, Y. Fujii, T. Fulghesu, E. Gabriel, G. Galati, M. D. Galati, A. Gallas Torreira, D. Galli, S. Gambetta, M. Gandelman, P. Gandini, B. Ganie, H. Gao, R. Gao, Y. Gao, M. Garau, L. M. Garcia Martin, P. Garcia Moreno, J. García Pardiñas, K. G. Garg, L. Garrido, C. Gaspar, R. E. Geertsema, L. L. Gerken, E. Gersabeck, M. Gersabeck, T. Gershon, Z. Ghorbanimoghaddam, L. Giambastiani, F. I. Giasemis, V. Gibson, H. K. Giemza, A. L. Gilman, M. Giovannetti, A. Gioventù, P. Gironella Gironell, C. Giugliano, M. A. Giza, E. L. Gkougkousis, F. C. Glaser, V. V. Gligorov, C. Göbel, E. Golobardes, D. Golubkov, A. Golutvin, A. Gomes, S. Gomez Fernandez, F. Goncalves Abrantes, M. Goncerz, G. Gong, J. A. Gooding, I. V. Gorelov, C. Gotti, J. P. Grabowski, L. A. Granado Cardoso, E. Graugés, E. Graverini, L. Grazette, G. Graziani, A. T. Grecu, L. M. Greeven, N. A. Grieser, L. Grillo, S. Gromov, C. Gu, M. Guarise, M. Guittiere, V. Guliaeva, P. A. Günther, A.-K. Guseinov, E. Gushchin, Y. Guz, T. Gys, K. Habermann, T. Hadavizadeh, C. Hadjivasiliou, G. Haefeli, C. Haen, J. Haimberger, M. Hajheidari, M. M. Halvorsen, P. M. Hamilton, J. Hammerich, Q. Han, X. Han, S. Hansmann-Menzemer, L. Hao, N. Harnew, M. Hartmann, J. He, F. Hemmer, C. Henderson, R. D. L. Henderson, A. M. Hennequin, K. Hennessy, L. Henry, J. Herd, J. Herdieckerhoff, P. Herrero Gascon, J. Heuel, A. Hicheur, G. Hijano Mendizabal, D. Hill, S. E. Hollitt, J. Horswill, R. Hou, Y. Hou, N. Howarth, J. Hu, W. Hu, X. Hu, W. Huang, W. Hulsbergen, R. J. Hunter, M. Hushchyn, D. Hutchcroft, D. Ilin, P. Ilten, A. Inglessi, A. Iniukhin, A. Ishteev, K. Ivshin, R. Jacobsson, H. Jage, S. J. Jaimes Elles, S. Jakobsen, E. Jans, B. K. Jashal, A. Jawahery, V. Jevtic, E. Jiang, X. Jiang, Y. Jiang, Y. J. Jiang, M. John, D. Johnson, C. R. Jones, T. P. Jones, S. Joshi, B. Jost, N. Jurik, I. Juszczak, D. Kaminaris, S. Kandybei, Y. Kang, C. Kar, M. Karacson, D. Karpenkov, A. M. Kauniskangas, J. W. Kautz, F. Keizer, M. Kenzie, T. Ketel, B. Khanji, A. Kharisova, S. Kholodenko, G. Khreich, T. Kirn, V. S. Kirsebom, O. Kitouni, S. Klaver, N. Kleijne, K. Klimaszewski, M. R. Kmiec, S. Koliiev, L. Kolk, A. Konoplyannikov, P. Kopciewicz, P. Koppenburg, M. Korolev, I. Kostiuk, O. Kot, S. Kotriakhova, A. Kozachuk, P. Kravchenko, L. Kravchuk, M. Kreps, P. Krokovny, W. Krupa, W. Krzemien, O. K. Kshyvanskyi, J. Kubat, S. Kubis, M. Kucharczyk, V. Kudryavtsev, E. Kulikova, A. Kupsc, B. K. Kutsenko, D. Lacarrere, A. Lai, A. Lampis, D. Lancierini, C. Landesa Gomez, J. J. Lane, R. Lane, C. Langenbruch, J. Langer, O. Lantwin, T. Latham, F. Lazzari, C. Lazzeroni, R. Le Gac, R. Lefèvre, A. Leflat, S. Legotin, M. Lehuraux, E. Lemos Cid, O. Leroy, T. Lesiak, B. Leverington, A. Li, H. Li, K. Li, L. Li, P. Li, P.-R. Li, Q. Li, S. Li, T. Li, Y. Li, Z. Lian, X. Liang, S. Libralon, C. Lin, T. Lin, R. Lindner, V. Lisovskyi, R. Litvinov, F. L. Liu, G. Liu, K. Liu, S. Liu, Y. Liu, Y. L. Liu, A. Lobo Salvia, A. Loi, J. Lomba Castro, T. Long, J. H. Lopes, A. Lopez Huertas, S. López Soliño, C. Lucarelli, D. Lucchesi, M. Lucio Martinez, V. Lukashenko, Y. Luo, A. Lupato, E. Luppi, K. Lynch, X.-R. Lyu, G. M. Ma, R. Ma, S. Maccolini, F. Machefert, F. Maciuc, B. M. Mack, I. Mackay, L. M. Mackey, L. R. Madhan Mohan, M. J. Madurai, A. Maevskiy, D. Magdalinski, D. Maisuzenko, M. W. Majewski, J. J. Malczewski, S. Malde, L. Malentacca, A. Malinin, T. Maltsev, G. Manca, G. Mancinelli, C. Mancuso, R. Manera Escalero, D. Manuzzi, D. Marangotto, J. F. Marchand, R. Marchevski, U. Marconi, S. Mariani, C. Marin Benito, J. Marks, A. M. Marshall, G. Martelli, G. Martellotti, L. Martinazzoli, M. Martinelli, D. Martinez Santos, F. Martinez Vidal, A. Massafferri, R. Matev, A. Mathad, V. Matiunin, C. Matteuzzi, K. R. Mattioli, A. Mauri, E. Maurice, J. Mauricio, P. Mayencourt, M. Mazurek, M. McCann, L. Mcconnell, T. H. McGrath, N. T. McHugh, A. McNab, R. McNulty, B. Meadows, G. Meier, D. Melnychuk, F. M. Meng, M. Merk, A. Merli, L. Meyer Garcia, D. Miao, H. Miao, M. Mikhasenko, D. A. Milanes, A. Minotti, E. Minucci, T. Miralles, B. Mitreska, D. S. Mitzel, A. Modak, A. Mödden, R. A. Mohammed, R. D. Moise, S. Mokhnenko, T. Mombächer, M. Monk, S. Monteil, A. Morcillo Gomez, G. Morello, M. J. Morello, M. P. Morgenthaler, A. B. Morris, A. G. Morris, R. Mountain, H. Mu, Z. M. Mu, E. Muhammad, F. Muheim, M. Mulder, K. Müller, F. Muñoz-Rojas, R. Murta, P. Naik, T. Nakada, R. Nandakumar, T. Nanut, I. Nasteva, M. Needham, N. Neri, S. Neubert, N. Neufeld, P. Neustroev, J. Nicolini, D. Nicotra, E. M. Niel, N. Nikitin, P. Nogga, N. S. Nolte, C. Normand, J. Novoa Fernandez, G. Nowak, C. Nunez, H. N. Nur, A. Oblakowska-Mucha, V. Obraztsov, T. Oeser, S. Okamura, R. Oldeman, F. Oliva, M. Olocco, C. J. G. Onderwater, R. H. O’Neil, J. M. Otalora Goicochea, P. Owen, A. Oyanguren, O. Ozcelik, K. O. Padeken, B. Pagare, P. R. Pais, T. Pajero, A. Palano, M. Palutan, G. Panshin, L. Paolucci, A. Papanestis, M. Pappagallo, L. L. Pappalardo, C. Pappenheimer, C. Parkes, B. Passalacqua, G. Passaleva, D. Passaro, A. Pastore, M. Patel, J. Patoc, C. Patrignani, C. J. Pawley, A. Pellegrino, J. Peng, M. Pepe Altarelli, S. Perazzini, D. Pereima, A. Pereiro Castro, P. Perret, A. Perro, K. Petridis, A. Petrolini, J. P. Pfaller, H. Pham, L. Pica, M. Piccini, B. Pietrzyk, G. Pietrzyk, D. Pinci, F. Pisani, M. Pizzichemi, V. Placinta, M. Plo Casasus, F. Polci, M. Poli Lener, A. Poluektov, N. Polukhina, I. Polyakov, E. Polycarpo, S. Ponce, D. Popov, S. Poslavskii, K. Prasanth, C. Prouve, V. Pugatch, G. Punzi, W. Qian, N. Qin, S. Qu, R. Quagliani, R. I. Rabadan Trejo, J. H. Rademacker, M. Rama, M. Ramírez García, M. Ramos Pernas, M. S. Rangel, F. Ratnikov, G. Raven, M. Rebollo De Miguel, F. Redi, J. Reich, F. Reiss, Z. Ren, P. K. Resmi, R. Ribatti, G. R. Ricart, D. Riccardi, S. Ricciardi, K. Richardson, M. Richardson-Slipper, K. Rinnert, P. Robbe, G. Robertson, E. Rodrigues, E. Rodriguez Fernandez, J. A. Rodriguez Lopez, E. Rodriguez Rodriguez, A. Rogovskiy, D. L. Rolf, P. Roloff, V. Romanovskiy, M. Romero Lamas, A. Romero Vidal, G. Romolini, F. Ronchetti, M. Rotondo, S. R. Roy, M. S. Rudolph, T. Ruf, M. Ruiz Diaz, R. A. Ruiz Fernandez, J. Ruiz Vidal, A. Ryzhikov, J. Ryzka, J. J. Saavedra Arias, J. J. Saborido Silva, R. Sadek, N. Sagidova, D. S. Sahoo, N. Sahoo, B. Saitta, M. Salomoni, C. Sanchez Gras, I. Sanderswood, R. Santacesaria, C. Santamarina Rios, M. Santimaria, L. Santoro, E. Santovetti, A. Saputi, D. Saranin, G. Sarpis, M. Sarpis, C. Satriano, A. Satta, M. Saur, D. Savrina, H. Sazak, L. G. Scantlebury Smead, A. Scarabotto, S. Schael, S. Scherl, M. Schiller, H. Schindler, M. Schmelling, B. Schmidt, S. Schmitt, H. Schmitz, O. Schneider, A. Schopper, N. Schulte, S. Schulte, M. H. Schune, R. Schwemmer, G. Schwering, B. Sciascia, A. Sciuccati, S. Sellam, A. Semennikov, T. Senger, M. Senghi Soares, A. Sergi, N. Serra, L. Sestini, A. Seuthe, Y. Shang, D. M. Shangase, M. Shapkin, R. S. Sharma, I. Shchemerov, L. Shchutska, T. Shears, L. Shekhtman, Z. Shen, S. Sheng, V. Shevchenko, B. Shi, Q. Shi, E. B. Shields, Y. Shimizu, E. Shmanin, R. Shorkin, J. D. Shupperd, R. Silva Coutinho, G. Simi, S. Simone, N. Skidmore, T. Skwarnicki, M. W. Slater, J. C. Smallwood, E. Smith, K. Smith, M. Smith, A. Snoch, L. Soares Lavra, M. D. Sokoloff, F. J. P. Soler, A. Solomin, A. Solovev, I. Solovyev, R. Song, Y. Song, Y. S. Song, F. L. Souza De Almeida, B. Souza De Paula, E. Spadaro Norella, E. Spedicato, J. G. Speer, E. Spiridenkov, P. Spradlin, V. Sriskaran, F. Stagni, M. Stahl, S. Stahl, S. Stanislaus, E. N. Stein, O. Steinkamp, O. Stenyakin, H. Stevens, D. Strekalina, Y. Su, F. Suljik, J. Sun, L. Sun, Y. Sun, D. S. Sundfeld Lima, W. Sutcliffe, P. N. Swallow, F. Swystun, A. Szabelski, T. Szumlak, Y. Tan, M. D. Tat, A. Terentev, F. Terzuoli, F. Teubert, E. Thomas, D. J. D. Thompson, H. Tilquin, V. Tisserand, S. T’Jampens, M. Tobin, L. Tomassetti, G. Tonani, X. Tong, D. Torres Machado, L. Toscano, D. Y. Tou, C. Trippl, G. Tuci, N. Tuning, L. H. Uecker, A. Ukleja, D. J. Unverzagt, E. Ursov, A. Usachov, A. Ustyuzhanin, U. Uwer, V. Vagnoni, A. Valassi, G. Valenti, N. Valls Canudas, H. Van Hecke, E. van Herwijnen, C. B. Van Hulse, R. Van Laak, M. van Veghel, G. Vasquez, R. Vazquez Gomez, P. Vazquez Regueiro, C. Vázquez Sierra, S. Vecchi, J. J. Velthuis, M. Veltri, A. Venkateswaran, M. Vesterinen, M. Vieites Diaz, X. Vilasis-Cardona, E. Vilella Figueras, A. Villa, P. Vincent, F. C. Volle, D. vom Bruch, N. Voropaev, K. Vos, G. Vouters, C. Vrahas, J. Walsh, E. J. Walton, G. Wan, C. Wang, G. Wang, J. Wang, M. Wang, N. W. Wang, R. Wang, X. Wang, X. W. Wang, Z. Wang, J. A. Ward, M. Waterlaat, N. K. Watson, D. Websdale, Y. Wei, J. Wendel, B. D. C. Westhenry, D. J. White, M. Whitehead, A. R. Wiederhold, D. Wiedner, G. Wilkinson, M. K. Wilkinson, M. Williams, M. R. J. Williams, R. Williams, F. F. Wilson, W. Wislicki, M. Witek, L. Witola, C. P. Wong, G. Wormser, S. A. Wotton, H. Wu, J. Wu, Y. Wu, K. Wyllie, S. Xian, Z. Xiang, Y. Xie, A. Xu, J. Xu, L. Xu, M. Xu, Z. Xu, D. Yang, S. Yang, X. Yang, Y. Yang, Z. Yang, V. Yeroshenko, H. Yeung, H. Yin, C. Y. Yu, J. Yu, X. Yuan, E. Zaffaroni, M. Zavertyaev, M. Zdybal, M. Zeng, C. Zhang, D. Zhang, J. Zhang, L. Zhang, S. Zhang, Y. Zhang, Y. Z. Zhang, Y. Zhao, A. Zharkova, A. Zhelezov, X. Z. Zheng, Y. Zheng, T. Zhou, X. Zhou, Y. Zhou, V. Zhovkovska, L. Z. Zhu, X. Zhu, V. Zhukov, J. Zhuo, Q. Zou, D. Zuliani, and G. Zunica
Subjects: Branching fraction, Charm Physics, Hadron-Hadron Scattering, Spectroscopy, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract: Abstract The decays of the B + meson to the final state D ∗ − D s + π + $$ {D}^{\ast -}{D}_s^{+}{\pi}^{+} $$ are studied in proton-proton collision data collected with the LHCb detector at centre-of-mass energies of 7, 8, and 13 TeV, corresponding to a total integrated luminosity of 9 fb −1. The ratio of branching fractions of the B + → D ∗ − D s + π + $$ {B}^{+}\to {D}^{\ast -}{D}_s^{+}{\pi}^{+} $$ and B 0 → D ∗ − D s + $$ {B}^0\to {D}^{\ast -}{D}_s^{+} $$ decays is measured to be 0.173 ± 0.006 ± 0.010, where the first uncertainty is statistical and the second is systematic. Using partially reconstructed D s ∗ + → D s + γ $$ {D}_s^{\ast +}\to {D}_s^{+}\gamma $$ and D s + π 0 $$ {D}_s^{+}{\pi}^0 $$ decays, the ratio of branching fractions between the B + → D ∗ − D s ∗ + π + $$ {B}^{+}\to {D}^{\ast -}{D}_s^{\ast +}{\pi}^{+} $$ and B + → D ∗ − D s + π + $$ {B}^{+}\to {D}^{\ast -}{D}_s^{+}{\pi}^{+} $$ decays is determined as 1.31 ± 0.07 ± 0.14. An amplitude analysis of the B + → D ∗ − D s + π + $$ {B}^{+}\to {D}^{\ast -}{D}_s^{+}{\pi}^{+} $$ decay is performed for the first time, revealing dominant contributions from known excited charm resonances decaying to the D *− π + final state. No significant evidence of exotic contributions in the D s + π + $$ {D}_s^{+}{\pi}^{+} $$ or D ∗ − D s + $$ {D}^{\ast -}{D}_s^{+} $$ channels is found. The fit fraction of the scalar state T c s ¯ 0 ∗ 2900 + + $$ {T}_{c\overline{s}0}^{\ast }{(2900)}^{++} $$ observed in the B + → D − D s + π + $$ {B}^{+}\to {D}^{-}{D}_s^{+}{\pi}^{+} $$ decay is determined to be less than 2.3% at a 90% confidence level.
Published: 2024
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19. Potassium dependent structural changes in the selectivity filter of HERG potassium channels

Author: Carus H. Y. Lau, Emelie Flood, Mark J. Hunter, Billy J. Williams-Noonan, Karen M. Corbett, Chai-Ann Ng, James C. Bouwer, Alastair G. Stewart, Eduardo Perozo, Toby W. Allen, and Jamie I. Vandenberg
Subjects: Science
Abstract: Abstract The fine tuning of biological electrical signaling is mediated by variations in the rates of opening and closing of gates that control ion flux through different ion channels. Human ether-a-go-go related gene (HERG) potassium channels have uniquely rapid inactivation kinetics which are critical to the role they play in regulating cardiac electrical activity. Here, we exploit the K+ sensitivity of HERG inactivation to determine structures of both a conductive and non-conductive selectivity filter structure of HERG. The conductive state has a canonical cylindrical shaped selectivity filter. The non-conductive state is characterized by flipping of the selectivity filter valine backbone carbonyls to point away from the central axis. The side chain of S620 on the pore helix plays a central role in this process, by coordinating distinct sets of interactions in the conductive, non-conductive, and transition states. Our model represents a distinct mechanism by which ion channels fine tune their activity and could explain the uniquely rapid inactivation kinetics of HERG.
Published: 2024
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20. Amplitude analysis of the radiative decay B s 0 $$ {\textrm{B}}_{\textrm{s}}^0 $$ → K+K − γ

Author: The LHCb collaboration, R. Aaij, A. S. W. Abdelmotteleb, C. Abellan Beteta, F. Abudinén, T. Ackernley, A. A. Adefisoye, B. Adeva, M. Adinolfi, P. Adlarson, C. Agapopoulou, C. A. Aidala, Z. Ajaltouni, S. Akar, K. Akiba, P. Albicocco, J. Albrecht, F. Alessio, M. Alexander, Z. Aliouche, P. Alvarez Cartelle, R. Amalric, S. Amato, J. L. Amey, Y. Amhis, L. An, L. Anderlini, M. Andersson, A. Andreianov, P. Andreola, M. Andreotti, D. Andreou, A. Anelli, D. Ao, F. Archilli, M. Argenton, S. Arguedas Cuendis, A. Artamonov, M. Artuso, E. Aslanides, M. Atzeni, B. Audurier, D. Bacher, I. Bachiller Perea, S. Bachmann, M. Bachmayer, J. J. Back, P. Baladron Rodriguez, V. Balagura, W. Baldini, H. Bao, J. Baptista de Souza Leite, M. Barbetti, I. R. Barbosa, R. J. Barlow, M. Barnyakov, S. Barsuk, W. Barter, M. Bartolini, J. Bartz, F. Baryshnikov, J. M. Basels, G. Bassi, B. Batsukh, A. Battig, A. Bay, A. Beck, M. Becker, F. Bedeschi, I. B. Bediaga, S. Belin, V. Bellee, K. Belous, I. Belov, I. Belyaev, G. Benane, G. Bencivenni, E. Ben-Haim, A. Berezhnoy, R. Bernet, S. Bernet Andres, A. Bertolin, C. Betancourt, F. Betti, J. Bex, Ia. Bezshyiko, J. Bhom, M. S. Bieker, N. V. Biesuz, P. Billoir, A. Biolchini, M. Birch, F. C. R. Bishop, A. Bitadze, A. Bizzeti, T. Blake, F. Blanc, J. E. Blank, S. Blusk, V. Bocharnikov, J. A. Boelhauve, O. Boente Garcia, T. Boettcher, A. Bohare, A. Boldyrev, C. S. Bolognani, R. Bolzonella, N. Bondar, F. Borgato, S. Borghi, M. Borsato, J. T. Borsuk, S. A. Bouchiba, T. J. V. Bowcock, A. Boyer, C. Bozzi, M. J. Bradley, A. Brea Rodriguez, N. Breer, J. Brodzicka, A. Brossa Gonzalo, J. Brown, D. Brundu, E. Buchanan, A. Buonaura, L. Buonincontri, A. T. Burke, C. Burr, A. Butkevich, J. S. Butter, J. Buytaert, W. Byczynski, S. Cadeddu, H. Cai, R. Calabrese, S. Calderon Ramirez, L. Calefice, S. Cali, M. Calvi, M. Calvo Gomez, P. Camargo Magalhaes, J. I. Cambon Bouzas, P. Campana, D. H. Campora Perez, A. F. Campoverde Quezada, S. Capelli, L. Capriotti, R. Caravaca-Mora, A. Carbone, L. Carcedo Salgado, R. Cardinale, A. Cardini, P. Carniti, L. Carus, A. Casais Vidal, R. Caspary, G. Casse, J. Castro Godinez, M. Cattaneo, G. Cavallero, V. Cavallini, S. Celani, D. Cervenkov, S. Cesare, A. J. Chadwick, I. Chahrour, M. Charles, Ph. Charpentier, C. A. Chavez Barajas, M. Chefdeville, C. Chen, S. Chen, Z. Chen, A. Chernov, S. Chernyshenko, V. Chobanova, S. Cholak, M. Chrzaszcz, A. Chubykin, V. Chulikov, P. Ciambrone, X. Cid Vidal, G. Ciezarek, P. Cifra, P. E. L. Clarke, M. Clemencic, H. V. Cliff, J. Closier, C. Cocha Toapaxi, V. Coco, J. Cogan, E. Cogneras, L. Cojocariu, P. Collins, T. Colombo, A. Comerma-Montells, L. Congedo, A. Contu, N. Cooke, I. Corredoira, A. Correia, G. Corti, J. J. Cottee Meldrum, B. Couturier, D. C. Craik, M. Cruz Torres, E. Curras Rivera, R. Currie, C. L. Da Silva, S. Dadabaev, L. Dai, X. Dai, E. Dall’Occo, J. Dalseno, C. D’Ambrosio, J. Daniel, A. Danilina, P. d’Argent, A. Davidson, J. E. Davies, A. Davis, O. De Aguiar Francisco, C. De Angelis, F. De Benedetti, J. de Boer, K. De Bruyn, S. De Capua, M. De Cian, U. De Freitas Carneiro Da Graca, E. De Lucia, J. M. De Miranda, L. De Paula, M. De Serio, P. De Simone, F. De Vellis, J. A. de Vries, F. Debernardis, D. Decamp, V. Dedu, L. Del Buono, B. Delaney, H.-P. Dembinski, J. Deng, V. Denysenko, O. Deschamps, F. Dettori, B. Dey, P. Di Nezza, I. Diachkov, S. Didenko, S. Ding, L. Dittmann, V. Dobishuk, A. D. Docheva, C. Dong, A. M. Donohoe, F. Dordei, A. C. dos Reis, A. D. Dowling, W. Duan, P. Duda, M. W. Dudek, L. Dufour, V. Duk, P. Durante, M. M. Duras, J. M. Durham, O. D. Durmus, A. Dziurda, A. Dzyuba, S. Easo, E. Eckstein, U. Egede, A. Egorychev, V. Egorychev, S. Eisenhardt, E. Ejopu, S. Ek-In, L. Eklund, M. Elashri, J. Ellbracht, S. Ely, A. Ene, E. Epple, J. Eschle, S. Esen, T. Evans, F. Fabiano, L. N. Falcao, Y. Fan, B. Fang, L. Fantini, M. Faria, K. Farmer, D. Fazzini, L. Felkowski, M. Feng, M. Feo, M. Fernandez Gomez, A. D. Fernez, F. Ferrari, F. Ferreira Rodrigues, S. Ferreres Sole, M. Ferrillo, M. Ferro-Luzzi, S. Filippov, R. A. Fini, M. Fiorini, K. M. Fischer, D. S. Fitzgerald, C. Fitzpatrick, F. Fleuret, M. Fontana, L. F. Foreman, R. Forty, D. Foulds-Holt, M. Franco Sevilla, M. Frank, E. Franzoso, G. Frau, C. Frei, D. A. Friday, J. Fu, Q. Fuehring, Y. Fujii, T. Fulghesu, E. Gabriel, G. Galati, M. D. Galati, A. Gallas Torreira, D. Galli, S. Gambetta, M. Gandelman, P. Gandini, B. Ganie, H. Gao, R. Gao, Y. Gao, M. Garau, L. M. Garcia Martin, P. Garcia Moreno, J. García Pardiñas, K. G. Garg, L. Garrido, C. Gaspar, R. E. Geertsema, L. L. Gerken, E. Gersabeck, M. Gersabeck, T. Gershon, Z. Ghorbanimoghaddam, L. Giambastiani, F. I. Giasemis, V. Gibson, H. K. Giemza, A. L. Gilman, M. Giovannetti, A. Gioventù, P. Gironella Gironell, C. Giugliano, M. A. Giza, E. L. Gkougkousis, F. C. Glaser, V. V. Gligorov, C. Göbel, E. Golobardes, D. Golubkov, A. Golutvin, A. Gomes, S. Gomez Fernandez, F. Goncalves Abrantes, M. 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Jashal, A. Jawahery, V. Jevtic, E. Jiang, X. Jiang, Y. Jiang, Y. J. Jiang, M. John, D. Johnson, C. R. Jones, T. P. Jones, S. Joshi, B. Jost, N. Jurik, I. Juszczak, D. Kaminaris, S. Kandybei, Y. Kang, C. Kar, M. Karacson, D. Karpenkov, A. Kauniskangas, J. W. Kautz, F. Keizer, M. Kenzie, T. Ketel, B. Khanji, A. Kharisova, S. Kholodenko, G. Khreich, T. Kirn, V. S. Kirsebom, O. Kitouni, S. Klaver, N. Kleijne, K. Klimaszewski, M. R. Kmiec, S. Koliiev, L. Kolk, A. Konoplyannikov, P. Kopciewicz, P. Koppenburg, M. Korolev, I. Kostiuk, O. Kot, S. Kotriakhova, A. Kozachuk, P. Kravchenko, L. Kravchuk, M. Kreps, P. Krokovny, W. Krupa, W. Krzemien, O. K. Kshyvanskyi, J. Kubat, S. Kubis, M. Kucharczyk, V. Kudryavtsev, E. Kulikova, A. Kupsc, B. K. Kutsenko, D. Lacarrere, A. Lai, A. Lampis, D. Lancierini, C. Landesa Gomez, J. J. Lane, R. Lane, C. Langenbruch, J. Langer, O. Lantwin, T. Latham, F. Lazzari, C. Lazzeroni, R. Le Gac, R. Lefèvre, A. Leflat, S. Legotin, M. Lehuraux, E. Lemos Cid, O. 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Massafferri, R. Matev, A. Mathad, V. Matiunin, C. Matteuzzi, K. R. Mattioli, A. Mauri, E. Maurice, J. Mauricio, P. Mayencourt, M. Mazurek, M. McCann, L. Mcconnell, T. H. McGrath, N. T. McHugh, A. McNab, R. McNulty, B. Meadows, G. Meier, D. Melnychuk, F. M. Meng, M. Merk, A. Merli, L. Meyer Garcia, D. Miao, H. Miao, M. Mikhasenko, D. A. Milanes, A. Minotti, E. Minucci, T. Miralles, B. Mitreska, D. S. Mitzel, A. Modak, A. Mödden, R. A. Mohammed, R. D. Moise, S. Mokhnenko, T. Mombächer, M. Monk, S. Monteil, A. Morcillo Gomez, G. Morello, M. J. Morello, M. P. Morgenthaler, A. B. Morris, A. G. Morris, R. Mountain, H. Mu, Z. M. Mu, E. Muhammad, F. Muheim, M. Mulder, K. Müller, F. Muñoz-Rojas, R. Murta, P. Naik, T. Nakada, R. Nandakumar, T. Nanut, I. Nasteva, M. Needham, N. Neri, S. Neubert, N. Neufeld, P. Neustroev, J. Nicolini, D. Nicotra, E. M. Niel, N. Nikitin, P. Nogga, N. S. Nolte, C. Normand, J. Novoa Fernandez, G. Nowak, C. Nunez, H. N. Nur, A. Oblakowska-Mucha, V. Obraztsov, T. 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Wang, X. Wang, X. W. Wang, Z. Wang, J. A. Ward, M. Waterlaat, N. K. Watson, D. Websdale, Y. Wei, J. Wendel, B. D. C. Westhenry, D. J. White, M. Whitehead, A. R. Wiederhold, D. Wiedner, G. Wilkinson, M. K. Wilkinson, M. Williams, M. R. J. Williams, R. Williams, F. F. Wilson, W. Wislicki, M. Witek, L. Witola, C. P. Wong, G. Wormser, S. A. Wotton, H. Wu, J. Wu, Y. Wu, K. Wyllie, S. Xian, Z. Xiang, Y. Xie, A. Xu, J. Xu, L. Xu, M. Xu, Z. Xu, D. Yang, S. Yang, X. Yang, Y. Yang, Z. Yang, V. Yeroshenko, H. Yeung, H. Yin, C. Y. Yu, J. Yu, X. Yuan, E. Zaffaroni, M. Zavertyaev, M. Zdybal, M. Zeng, C. Zhang, D. Zhang, J. Zhang, L. Zhang, S. Zhang, Y. Zhang, Y. Z. Zhang, Y. Zhao, A. Zharkova, A. Zhelezov, X. Z. Zheng, Y. Zheng, T. Zhou, X. Zhou, Y. Zhou, V. Zhovkovska, L. Z. Zhu, X. Zhu, V. Zhukov, J. Zhuo, Q. Zou, D. Zuliani, and G. Zunica
Subjects: B Physics, Flavour Physics, Hadron-Hadron Scattering, Rare Decay, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract: Abstract A search for radiative decay of B s 0 $$ {B}_s^0 $$ mesons to orbitally excited K + K − states is performed using proton proton collisions recorded by the LHCb experiment, corresponding to an integrated luminosity of 9 fb −1. The dikaon spectrum in the mass range m KK < 2400 MeV/c 2 is dominated by the ϕ(1020) resonance that accounts for almost 70% of the decay rate. Considering the possible contributions of f 2(1270), f 2 ′ $$ {f}_2^{\prime } $$ (1525) and f 2(2010) meson states, the overall tensor contribution to the amplitude is measured to be F f 2 = 16.8 ± 0.5 stat . ± 0.7 syst . % , $$ {\mathcal{F}}_{\left\{{f}_2\right\}}=16.8\pm 0.5\left(\textrm{stat}.\right)\pm 0.7\left(\textrm{syst}.\right)\%, $$ mostly dominated by the f 2 ′ $$ {f}_2^{\prime } $$ (1525) state. Several statistically equivalent solutions are obtained for the detailed resonant structure depending on whether the smaller amplitudes interfere destructively or constructively with the dominant amplitude. The preferred solution that corresponds to the lowest values of the fit fractions along with constructive interference leads to the relative branching ratio measurement B B s 0 → f 2 ′ γ B B s 0 → ϕγ = 19.4 − 0.8 + 0.9 stat . − 0.5 + 1.4 syst . ± 0.5 B % , $$ \frac{\mathcal{B}\left({B}_s^0\to {f}_2^{\prime}\gamma \right)}{\mathcal{B}\left({B}_s^0\to \phi \gamma \right)}={19.4}_{-0.8}^{+0.9}{\left(\textrm{stat}.\right)}_{-0.5}^{+1.4}\left(\textrm{syst}.\right)\pm 0.5\left(\mathcal{B}\right)\%, $$ where the last uncertainty is due to the ratio of measured branching fractions to the K + K − final state. This result represents the first observation of the radiative B s 0 → f 2 ′ 1525 γ $$ {B}_s^0\to {f}_2^{\prime }(1525)\gamma $$ decay, which is the second radiative transition observed in the B s 0 $$ {B}_s^0 $$ sector.
Published: 2024
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21. Study of b-hadron decays to Λ c + h − h ′ − $$ {\Lambda}_c^{+}{h}^{-}{h}^{\prime -} $$ final states

Author: The LHCb collaboration, R. Aaij, A. S. W. Abdelmotteleb, C. Abellan Beteta, F. Abudinén, T. Ackernley, A. A. Adefisoye, B. Adeva, M. Adinolfi, P. Adlarson, C. Agapopoulou, C. A. Aidala, Z. Ajaltouni, S. Akar, K. Akiba, P. Albicocco, J. Albrecht, F. Alessio, M. Alexander, Z. Aliouche, P. Alvarez Cartelle, R. Amalric, S. Amato, J. L. Amey, Y. Amhis, L. An, L. Anderlini, M. Andersson, A. Andreianov, P. Andreola, M. Andreotti, D. Andreou, A. Anelli, D. Ao, F. Archilli, M. Argenton, S. Arguedas Cuendis, A. Artamonov, M. Artuso, E. Aslanides, R. Ataide Da Silva, M. Atzeni, B. Audurier, D. Bacher, I. Bachiller Perea, S. Bachmann, M. Bachmayer, J. J. Back, P. Baladron Rodriguez, V. Balagura, W. Baldini, H. Bao, J. Baptista de Souza Leite, M. Barbetti, I. R. Barbosa, R. J. Barlow, M. Barnyakov, S. Barsuk, W. Barter, M. Bartolini, J. Bartz, J. M. Basels, G. Bassi, B. Batsukh, A. Bay, A. Beck, M. Becker, F. Bedeschi, I. B. Bediaga, S. Belin, V. Bellee, K. Belous, I. Belov, I. Belyaev, G. Benane, G. Bencivenni, E. Ben-Haim, A. Berezhnoy, R. Bernet, S. Bernet Andres, A. Bertolin, C. Betancourt, F. Betti, J. Bex, Ia. Bezshyiko, J. Bhom, M. S. Bieker, N. V. Biesuz, P. Billoir, A. Biolchini, M. Birch, F. C. R. Bishop, A. Bitadze, A. Bizzeti, T. Blake, F. Blanc, J. E. Blank, S. Blusk, V. Bocharnikov, J. A. Boelhauve, O. Boente Garcia, T. Boettcher, A. Bohare, A. Boldyrev, C. S. Bolognani, R. Bolzonella, N. Bondar, F. Borgato, S. Borghi, M. Borsato, J. T. Borsuk, S. A. Bouchiba, T. J. V. Bowcock, A. Boyer, C. Bozzi, A. Brea Rodriguez, N. Breer, J. Brodzicka, A. Brossa Gonzalo, J. Brown, D. Brundu, E. Buchanan, A. Buonaura, L. Buonincontri, A. T. Burke, C. Burr, A. Butkevich, J. S. Butter, J. Buytaert, W. Byczynski, S. Cadeddu, H. Cai, R. Calabrese, S. Calderon Ramirez, L. Calefice, S. Cali, M. Calvi, M. Calvo Gomez, P. Camargo Magalhaes, J. I. Cambon Bouzas, P. Campana, D. H. Campora Perez, A. F. Campoverde Quezada, S. Capelli, L. Capriotti, R. Caravaca-Mora, A. Carbone, L. Carcedo Salgado, R. Cardinale, A. Cardini, P. Carniti, L. Carus, A. Casais Vidal, R. Caspary, G. Casse, J. Castro Godinez, M. Cattaneo, G. Cavallero, V. Cavallini, S. Celani, D. Cervenkov, S. Cesare, A. J. Chadwick, I. Chahrour, M. Charles, Ph. Charpentier, E. Chatzianagnostou, C. A. Chavez Barajas, M. Chefdeville, C. Chen, S. Chen, Z. Chen, A. Chernov, S. Chernyshenko, V. Chobanova, S. Cholak, M. Chrzaszcz, A. Chubykin, V. Chulikov, P. Ciambrone, X. Cid Vidal, G. Ciezarek, P. Cifra, P. E. L. Clarke, M. Clemencic, H. V. Cliff, J. Closier, C. Cocha Toapaxi, V. Coco, J. Cogan, E. Cogneras, L. Cojocariu, P. Collins, T. Colombo, A. Comerma-Montells, L. Congedo, A. Contu, N. Cooke, I. Corredoira, A. Correia, G. Corti, J. J. Cottee Meldrum, B. Couturier, D. C. Craik, M. Cruz Torres, E. Curras Rivera, R. Currie, C. L. Da Silva, S. Dadabaev, L. Dai, X. Dai, E. Dall’Occo, J. Dalseno, C. D’Ambrosio, J. Daniel, A. Danilina, P. d’Argent, A. Davidson, J. E. Davies, A. Davis, O. De Aguiar Francisco, C. De Angelis, F. De Benedetti, J. de Boer, K. De Bruyn, S. De Capua, M. De Cian, U. De Freitas Carneiro Da Graca, E. De Lucia, J. M. De Miranda, L. De Paula, M. De Serio, P. De Simone, F. De Vellis, J. A. de Vries, F. Debernardis, D. Decamp, V. Dedu, L. Del Buono, B. Delaney, H.-P. Dembinski, J. Deng, V. Denysenko, O. Deschamps, F. Dettori, B. Dey, P. Di Nezza, I. Diachkov, S. Didenko, S. Ding, L. Dittmann, V. Dobishuk, A. D. Docheva, C. Dong, A. M. Donohoe, F. Dordei, A. C. dos Reis, A. D. Dowling, W. Duan, P. Duda, M. W. Dudek, L. Dufour, V. Duk, P. Durante, M. M. Duras, J. M. Durham, O. D. Durmus, A. Dziurda, A. Dzyuba, S. Easo, E. Eckstein, U. Egede, A. Egorychev, V. Egorychev, S. Eisenhardt, E. Ejopu, L. Eklund, M. Elashri, J. Ellbracht, S. Ely, A. Ene, E. Epple, J. Eschle, S. Esen, T. Evans, F. Fabiano, L. N. Falcao, Y. Fan, B. Fang, L. Fantini, M. Faria, K. Farmer, D. Fazzini, L. Felkowski, M. Feng, M. Feo, A. Fernandez Casani, M. Fernandez Gomez, A. D. Fernez, F. Ferrari, F. Ferreira Rodrigues, M. Ferrillo, M. Ferro-Luzzi, S. Filippov, R. A. Fini, M. Fiorini, K. M. Fischer, D. S. Fitzgerald, C. Fitzpatrick, F. Fleuret, M. Fontana, L. F. Foreman, R. Forty, D. Foulds-Holt, M. Franco Sevilla, M. Frank, E. Franzoso, G. Frau, C. Frei, D. A. Friday, J. Fu, Q. Fuehring, Y. Fujii, T. Fulghesu, E. Gabriel, G. Galati, M. D. Galati, A. Gallas Torreira, D. Galli, S. Gambetta, M. Gandelman, P. Gandini, B. Ganie, H. Gao, R. Gao, Y. Gao, M. Garau, L. M. Garcia Martin, P. Garcia Moreno, J. García Pardiñas, K. G. Garg, L. Garrido, C. Gaspar, R. E. Geertsema, L. L. Gerken, E. Gersabeck, M. Gersabeck, T. Gershon, Z. Ghorbanimoghaddam, L. Giambastiani, F. I. Giasemis, V. Gibson, H. K. Giemza, A. L. Gilman, M. Giovannetti, A. Gioventù, L. Girardey, P. Gironella Gironell, C. Giugliano, M. A. Giza, E. L. Gkougkousis, F. C. Glaser, V. V. Gligorov, C. Göbel, E. Golobardes, D. Golubkov, A. Golutvin, A. Gomes, S. Gomez Fernandez, F. Goncalves Abrantes, M. Goncerz, G. Gong, J. A. Gooding, I. V. Gorelov, C. Gotti, J. P. Grabowski, L. A. Granado Cardoso, E. Graugés, E. Graverini, L. Grazette, G. Graziani, A. T. Grecu, L. M. Greeven, N. A. Grieser, L. Grillo, S. Gromov, C. Gu, M. Guarise, M. Guittiere, V. Guliaeva, P. A. Günther, A.-K. Guseinov, E. Gushchin, Y. Guz, T. Gys, K. Habermann, T. Hadavizadeh, C. Hadjivasiliou, G. Haefeli, C. Haen, J. Haimberger, M. Hajheidari, M. M. Halvorsen, P. M. Hamilton, J. Hammerich, Q. Han, X. Han, S. Hansmann-Menzemer, L. Hao, N. Harnew, M. Hartmann, J. He, F. Hemmer, C. Henderson, R. D. L. Henderson, A. M. Hennequin, K. Hennessy, L. Henry, J. Herd, P. Herrero Gascon, J. Heuel, A. Hicheur, G. Hijano Mendizabal, D. Hill, S. E. Hollitt, J. Horswill, R. Hou, Y. Hou, N. Howarth, J. Hu, W. Hu, X. Hu, W. Huang, W. Hulsbergen, R. J. Hunter, M. Hushchyn, D. Hutchcroft, D. Ilin, P. Ilten, A. Inglessi, A. Iniukhin, A. Ishteev, K. Ivshin, R. Jacobsson, H. Jage, S. J. Jaimes Elles, S. Jakobsen, E. Jans, B. K. Jashal, A. Jawahery, V. Jevtic, E. Jiang, X. Jiang, Y. Jiang, Y. J. Jiang, M. John, D. Johnson, C. R. Jones, T. P. Jones, S. Joshi, B. Jost, N. Jurik, I. Juszczak, D. Kaminaris, S. Kandybei, M. Kane, Y. Kang, C. Kar, M. Karacson, D. Karpenkov, A. Kauniskangas, J. W. Kautz, F. Keizer, M. Kenzie, T. Ketel, B. Khanji, A. Kharisova, S. Kholodenko, G. Khreich, T. Kirn, V. S. Kirsebom, O. Kitouni, S. Klaver, N. Kleijne, K. Klimaszewski, M. R. Kmiec, S. Koliiev, L. Kolk, A. Konoplyannikov, P. Kopciewicz, P. Koppenburg, M. Korolev, I. Kostiuk, O. Kot, S. Kotriakhova, A. Kozachuk, P. Kravchenko, L. Kravchuk, M. Kreps, P. Krokovny, W. Krupa, W. Krzemien, O. K. Kshyvanskyi, J. Kubat, S. Kubis, M. Kucharczyk, V. Kudryavtsev, E. Kulikova, A. Kupsc, B. K. Kutsenko, D. Lacarrere, A. Lai, A. Lampis, D. Lancierini, C. Landesa Gomez, J. J. Lane, R. Lane, C. Langenbruch, J. Langer, O. Lantwin, T. Latham, F. Lazzari, C. Lazzeroni, R. Le Gac, R. Lefèvre, A. Leflat, S. Legotin, M. Lehuraux, E. Lemos Cid, O. Leroy, T. Lesiak, B. Leverington, A. Li, H. Li, K. Li, L. Li, P. Li, P.-R. Li, Q. Li, S. Li, T. Li, Y. Li, Z. Lian, X. Liang, S. Libralon, C. Lin, T. Lin, R. Lindner, V. Lisovskyi, R. Litvinov, F. L. Liu, G. Liu, K. Liu, S. Liu, Y. Liu, Y. L. Liu, A. Lobo Salvia, A. Loi, J. Lomba Castro, T. Long, J. H. Lopes, A. Lopez Huertas, S. López Soliño, C. Lucarelli, D. Lucchesi, M. Lucio Martinez, V. Lukashenko, Y. Luo, A. Lupato, E. Luppi, K. Lynch, X.-R. Lyu, G. M. Ma, R. Ma, S. Maccolini, F. Machefert, F. Maciuc, B. Mack, I. Mackay, L. M. Mackey, L. R. Madhan Mohan, M. J. Madurai, A. Maevskiy, D. Magdalinski, D. Maisuzenko, M. W. Majewski, J. J. Malczewski, S. Malde, L. Malentacca, A. Malinin, T. Maltsev, G. Manca, G. Mancinelli, C. Mancuso, R. Manera Escalero, D. Manuzzi, D. Marangotto, J. F. Marchand, R. Marchevski, U. Marconi, S. Mariani, C. Marin Benito, J. Marks, A. M. Marshall, G. Martelli, G. Martellotti, L. Martinazzoli, M. Martinelli, D. Martinez Santos, F. Martinez Vidal, A. Massafferri, R. Matev, A. Mathad, V. Matiunin, C. Matteuzzi, K. R. Mattioli, A. Mauri, E. Maurice, J. Mauricio, P. Mayencourt, J. Mazorra de Cos, M. Mazurek, M. McCann, L. Mcconnell, T. H. McGrath, N. T. McHugh, A. McNab, R. McNulty, B. Meadows, G. Meier, D. Melnychuk, F. M. Meng, M. Merk, A. Merli, L. Meyer Garcia, D. Miao, H. Miao, M. Mikhasenko, D. A. Milanes, A. Minotti, E. Minucci, T. Miralles, B. Mitreska, D. S. Mitzel, A. Modak, A. Mödden, R. A. Mohammed, R. D. Moise, S. Mokhnenko, T. Mombächer, M. Monk, S. Monteil, A. Morcillo Gomez, G. Morello, M. J. Morello, M. P. Morgenthaler, A. B. Morris, A. G. Morris, R. Mountain, H. Mu, Z. M. Mu, E. Muhammad, F. Muheim, M. Mulder, K. Müller, F. Muñoz-Rojas, R. Murta, P. Naik, T. Nakada, R. Nandakumar, T. Nanut, I. Nasteva, M. Needham, N. Neri, S. Neubert, N. Neufeld, P. Neustroev, J. Nicolini, D. Nicotra, E. M. Niel, N. Nikitin, P. Nogarolli, P. Nogga, N. S. Nolte, C. Normand, J. Novoa Fernandez, G. Nowak, C. Nunez, H. N. Nur, A. Oblakowska-Mucha, V. Obraztsov, T. Oeser, S. Okamura, A. Okhotnikov, O. Okhrimenko, R. Oldeman, F. Oliva, M. Olocco, C. J. G. Onderwater, R. H. O’Neil, J. M. Otalora Goicochea, P. Owen, A. Oyanguren, O. Ozcelik, A. Padee, K. O. Padeken, B. Pagare, P. R. Pais, T. Pajero, A. Palano, M. Palutan, G. Panshin, L. Paolucci, A. Papanestis, M. Pappagallo, L. L. Pappalardo, C. Pappenheimer, C. Parkes, B. Passalacqua, G. Passaleva, D. Passaro, A. Pastore, M. Patel, J. Patoc, C. Patrignani, A. Paul, C. J. Pawley, A. Pellegrino, J. Peng, M. Pepe Altarelli, S. Perazzini, D. Pereima, H. Pereira Da Costa, A. Pereiro Castro, P. Perret, A. Perro, K. Petridis, A. Petrolini, J. P. Pfaller, H. Pham, L. Pica, M. Piccini, B. Pietrzyk, G. Pietrzyk, D. Pinci, F. Pisani, M. Pizzichemi, V. Placinta, M. Plo Casasus, T. Poeschl, F. Polci, M. Poli Lener, A. Poluektov, N. Polukhina, I. Polyakov, E. Polycarpo, S. Ponce, D. Popov, S. Poslavskii, K. Prasanth, C. Prouve, V. Pugatch, G. Punzi, S. Qasim, Q. Q. Qian, W. Qian, N. Qin, S. Qu, R. Quagliani, R. I. Rabadan Trejo, J. H. Rademacker, M. Rama, M. Ramírez García, V. Ramos De Oliveira, M. Ramos Pernas, M. S. Rangel, F. Ratnikov, G. Raven, M. Rebollo De Miguel, F. Redi, J. Reich, F. Reiss, Z. Ren, P. K. Resmi, R. Ribatti, G. R. Ricart, D. Riccardi, S. Ricciardi, K. Richardson, M. Richardson-Slipper, K. Rinnert, P. Robbe, G. Robertson, E. Rodrigues, E. Rodriguez Fernandez, J. A. Rodriguez Lopez, E. Rodriguez Rodriguez, A. Rogovskiy, D. L. Rolf, P. Roloff, V. Romanovskiy, M. Romero Lamas, A. Romero Vidal, G. Romolini, F. Ronchetti, T. Rong, M. Rotondo, S. R. Roy, M. S. Rudolph, T. Ruf, M. Ruiz Diaz, R. A. Ruiz Fernandez, J. Ruiz Vidal, A. Ryzhikov, J. Ryzka, J. J. Saavedra-Arias, J. J. Saborido Silva, R. Sadek, N. Sagidova, D. Sahoo, N. Sahoo, B. Saitta, M. Salomoni, C. Sanchez Gras, I. Sanderswood, R. Santacesaria, C. Santamarina Rios, M. Santimaria, L. Santoro, E. Santovetti, A. Saputi, D. Saranin, A. S. Sarnatskiy, G. Sarpis, M. Sarpis, C. Satriano, A. Satta, M. Saur, D. Savrina, H. Sazak, L. G. Scantlebury Smead, A. Scarabotto, S. Schael, S. Scherl, M. Schiller, H. Schindler, M. Schmelling, B. Schmidt, S. Schmitt, H. Schmitz, O. Schneider, A. Schopper, N. Schulte, S. Schulte, M. H. Schune, R. Schwemmer, G. Schwering, B. Sciascia, A. Sciuccati, S. Sellam, A. Semennikov, T. Senger, M. Senghi Soares, A. Sergi, N. Serra, L. Sestini, A. Seuthe, Y. Shang, D. M. Shangase, M. Shapkin, R. S. Sharma, I. Shchemerov, L. Shchutska, T. Shears, L. Shekhtman, Z. Shen, S. Sheng, V. Shevchenko, B. Shi, Q. Shi, Y. Shimizu, E. Shmanin, R. Shorkin, J. D. Shupperd, R. Silva Coutinho, G. Simi, S. Simone, N. Skidmore, T. Skwarnicki, M. W. Slater, J. C. Smallwood, E. Smith, K. Smith, M. Smith, A. Snoch, L. Soares Lavra, M. D. Sokoloff, F. J. P. Soler, A. Solomin, A. Solovev, I. Solovyev, R. Song, Y. Song, Y. S. Song, F. L. Souza De Almeida, B. Souza De Paula, E. Spadaro Norella, E. Spedicato, J. G. Speer, E. Spiridenkov, P. Spradlin, V. Sriskaran, F. Stagni, M. Stahl, S. Stahl, S. Stanislaus, E. N. Stein, O. Steinkamp, O. Stenyakin, H. Stevens, D. Strekalina, Y. Su, F. Suljik, J. Sun, L. Sun, Y. Sun, D. S. Sundfeld Lima, W. Sutcliffe, P. N. Swallow, F. Swystun, A. Szabelski, T. Szumlak, Y. Tan, M. D. Tat, A. Terentev, F. Terzuoli, F. Teubert, E. Thomas, D. J. D. Thompson, H. Tilquin, V. Tisserand, S. T’Jampens, M. Tobin, L. Tomassetti, G. Tonani, X. Tong, D. Torres Machado, L. Toscano, D. Y. Tou, C. Trippl, G. Tuci, N. Tuning, L. H. Uecker, A. Ukleja, D. J. Unverzagt, E. Ursov, A. Usachov, A. Ustyuzhanin, U. Uwer, V. Vagnoni, G. Valenti, N. Valls Canudas, H. Van Hecke, E. van Herwijnen, C. B. Van Hulse, R. Van Laak, M. van Veghel, G. Vasquez, R. Vazquez Gomez, P. Vazquez Regueiro, C. Vázquez Sierra, S. Vecchi, J. J. Velthuis, M. Veltri, A. Venkateswaran, M. Vesterinen, M. Vieites Diaz, X. Vilasis-Cardona, E. Vilella Figueras, A. Villa, P. Vincent, F. C. Volle, D. vom Bruch, N. Voropaev, K. Vos, G. Vouters, C. Vrahas, J. Wagner, J. Walsh, E. J. Walton, G. Wan, C. Wang, G. Wang, J. Wang, M. Wang, N. W. Wang, R. Wang, X. Wang, X. W. Wang, Y. Wang, Z. Wang, J. A. Ward, M. Waterlaat, N. K. Watson, D. Websdale, Y. Wei, J. Wendel, B. D. C. Westhenry, D. J. White, M. Whitehead, E. Whiter, A. R. Wiederhold, D. Wiedner, G. Wilkinson, M. K. Wilkinson, M. Williams, M. R. J. Williams, R. Williams, F. F. Wilson, W. Wislicki, M. Witek, L. Witola, C. P. Wong, G. Wormser, S. A. Wotton, H. Wu, J. Wu, Y. Wu, K. Wyllie, S. Xian, Z. Xiang, Y. Xie, A. Xu, J. Xu, L. Xu, M. Xu, Z. Xu, D. Yang, K. Yang, S. Yang, X. Yang, Y. Yang, Z. Yang, V. Yeroshenko, H. Yeung, H. Yin, C. Y. Yu, J. Yu, X. Yuan, E. Zaffaroni, M. Zavertyaev, M. Zdybal, C. Zeng, M. Zeng, C. Zhang, D. Zhang, J. Zhang, L. Zhang, S. Zhang, Y. Zhang, Y. Z. Zhang, Y. Zhao, A. Zharkova, A. Zhelezov, S. Z. Zheng, X. Z. Zheng, Y. Zheng, T. Zhou, X. Zhou, Y. Zhou, V. Zhovkovska, L. Z. Zhu, X. Zhu, V. Zhukov, J. Zhuo, Q. Zou, D. Zuliani, and G. Zunica
Subjects: B Physics, Branching fraction, Hadron-Hadron Scattering, Heavy Quark Production, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract: Abstract Decays of Ξ b − $$ {\Xi}_b^{-} $$ and Ω b − $$ {\Omega}_b^{-} $$ baryons to Λ c + h − h ′ − $$ {\Lambda}_c^{+}{h}^{-}{h}^{\prime -} $$ final states, with h − h ′− being π − π − , K − π − and K − K − meson pairs, are searched for using data collected with the LHCb detector. The data sample studied corresponds to an integrated luminosity of 8.7 fb −1 of pp collisions collected at centre-of-mass energies s $$ \sqrt{s} $$ = 7, 8 and 13 TeV. The products of the relative branching fractions and fragmentation fractions for each signal mode, relative to the B − → Λ c + p ¯ π − $$ {B}^{-}\to {\Lambda}_c^{+}\overline{p}{\pi}^{-} $$ mode, are measured, with Ξ b − → Λ c + K − π − $$ {\Xi}_b^{-}\to {\Lambda}_c^{+}{K}^{-}{\pi}^{-} $$ , Ξ b − → Λ c + K − K − $$ {\Xi}_b^{-}\to {\Lambda}_c^{+}{K}^{-}{K}^{-} $$ and Ω b − → Λ c + K − K − $$ {\varOmega}_b^{-}\to {\Lambda}_c^{+}{K}^{-}{K}^{-} $$ decays being observed at over 5 σ significance. The Ξ b − → Λ c + K − π − $$ {\Xi}_b^{-}\to {\Lambda}_c^{+}{K}^{-}{\pi}^{-} $$ mode is also used to measure the Ξ b − $$ {\Xi}_b^{-} $$ production asymmetry, which is found to be consistent with zero. In addition, the B − → Λ c + p ¯ K − $$ {B}^{-}\to {\Lambda}_c^{+}\overline{p}{K}^{-} $$ decay is observed for the first time, and its branching fraction is measured relative to that of the B − → Λ c + p ¯ π − $$ {B}^{-}\to {\Lambda}_c^{+}\overline{p}{\pi}^{-} $$ mode.
Published: 2024
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22. The potential of residual clinical Group B Streptococcus swabs for assessing the vaginorectal microbiome in late pregnancy

Author: Laura K. Boelsen, Melanie J. Williams, Yeukai TM. Mangwiro, Herah Hansji, Anna Czajko, Vanessa Marcelino, Samuel Forster, Joanne M. Said, Catherine Satzke, and Richard Saffery
Subjects: Medicine, Science
Abstract: Abstract The maternal pregnancy microbiome (including genitourinary and gut) has been linked to important pregnancy/birth and later childhood health outcomes. However, such sampling as part of large population cohort studies is logistically and financially challenging. Many countries routinely collect vaginal or vaginal-rectal swabs in late pregnancy for Group B Streptococcus (GBS) screening, but their utility for population-based research is still unclear. As part of planning for the Generation Victoria population-based cohort study beginning in pregnancy, we assessed the utility and reliability of residual clinical GBS vaginal/vaginal-rectal swabs for generating late pregnancy microbiome data. We carried out a two-phased pilot study. Phase one assessed the level of microbial diversity apparent in ‘residual’ clinical vaginal/vaginal-rectal swabs post clinical testing and storage for 7–10 days at 4 °C (routine clinical practice). Phase two directly assessed the impact of storage time and temperature on the microbial composition of vaginal/vaginal-rectal swabs collected specifically for research purposes. The microbiota composition in the ‘residual’ clinical swabs aligned with published studies. The ‘research’ swabs, stored at 4 °C for up to ten days, showed minimal changes in microbiota profile, compared to swabs examined on the day of collection. In contrast, significant variation in diversity was seen in swabs stored at room temperature for up to 48 h. Residual clinical material from swabs collected primarily for GBS screening in late pregnancy represent a reliable and abundant source of material for assessing the late pregnancy maternal microbiome for research purposes. This represents a low-burden opportunity for population-representative pregnancy studies to assess the potential of late pregnancy microbiome for prediction and understanding maternal and child health outcomes.
Published: 2024
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23. How rainfall events modify trace gas mixing ratios in central Amazonia

Author: L. A. T. Machado, J. Kesselmeier, S. Botía, H. van Asperen, M. O. Andreae, A. C. de Araújo, P. Artaxo, A. Edtbauer, R. R. Ferreira, M. A. Franco, H. Harder, S. P. Jones, C. Q. Dias-Júnior, G. G. Haytzmann, C. A. Quesada, S. Komiya, J. Lavric, J. Lelieveld, I. Levin, A. Nölscher, E. Pfannerstill, M. L. Pöhlker, U. Pöschl, A. Ringsdorf, L. Rizzo, A. M. Yáñez-Serrano, S. Trumbore, W. I. D. Valenti, J. Vila-Guerau de Arellano, D. Walter, J. Williams, S. Wolff, and C. Pöhlker
Subjects: Physics, QC1-999, Chemistry, QD1-999
Abstract: This study investigates the rain-initiated mixing and variability in the mixing ratio of selected trace gases in the atmosphere over the central Amazon rain forest. It builds on comprehensive data from the Amazon Tall Tower Observatory (ATTO), spanning from 2013 to 2020 and comprising the greenhouse gases (GHGs) carbon dioxide (CO2) and methane (CH4); the reactive trace gases carbon monoxide (CO), ozone (O3), nitric oxide (NO), and nitrogen dioxide (NO2); and selected volatile organic compounds (VOCs). Based on more than 1000 analyzed rainfall events, the study resolves the trace gas mixing ratio patterns before, during, and after the rain events, along with vertical mixing ratio gradients across the forest canopy. The assessment of the rainfall events was conducted independently for daytime and nighttime periods, which allows us to elucidate the influence of solar radiation. The mixing ratios of CO2, CO, and CH4 clearly declined during rainfall, which can be attributed to the downdraft-related entrainment of pristine air from higher altitudes into the boundary layer, a reduction of the photosynthetic activity under increased cloud cover, and changes in the surface fluxes. Notably, CO showed a faster reduction than CO2, and the vertical gradient of CO2 and CO is steeper than for CH4. Conversely, the O3 mixing ratio increased across all measurement heights in the course of the rain-related downdrafts. Following the O3 enhancement by up to a factor of 2, NO, NO2, and isoprene mixing ratios decreased. The temporal and vertical variability of the trace gases is intricately linked to the diverse sink and source processes, surface fluxes, and free-troposphere transport. Within the canopy, several interactions unfold among soil, atmosphere, and plants, shaping the overall dynamics. Also, the mixing ratio of biogenic VOCs (BVOCs) clearly varied with rainfall, driven by factors such as light, temperature, physical transport, and soil processes. Our results disentangle the patterns in the trace gas mixing ratio in the course of sudden and vigorous atmospheric mixing during rainfall events. By selectively uncovering processes that are not clearly detectable under undisturbed conditions, our results contribute to a better understanding of the trace gas life cycle and its interplay with meteorology, cloud dynamics, and rainfall in the Amazon.
Published: 2024
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24. Tracking of charged particles with nanosecond lifetimes at LHCb

Author: LHCb Collaboration, R. Aaij, A. S. W. Abdelmotteleb, C. Abellan Beteta, F. Abudinén, T. Ackernley, J. A. Adams, A. A. Adefisoye, B. Adeva, M. Adinolfi, P. Adlarson, C. Agapopoulou, C. A. Aidala, Z. Ajaltouni, S. Akar, K. Akiba, P. Albicocco, J. Albrecht, F. Alessio, M. Alexander, Z. Aliouche, P. Alvarez Cartelle, R. Amalric, S. Amato, J. L. Amey, Y. Amhis, L. An, L. Anderlini, M. Andersson, A. Andreianov, P. Andreola, M. Andreotti, D. Andreou, A. Anelli, D. Ao, F. Archilli, M. Argenton, S. Arguedas Cuendis, A. Artamonov, M. Artuso, E. Aslanides, M. Atzeni, B. Audurier, D. Bacher, I. Bachiller Perea, S. Bachmann, M. Bachmayer, J. J. Back, P. Baladron Rodriguez, V. Balagura, W. Baldini, H. Bao, J. Baptista de Souza Leite, M. Barbetti, I. R. Barbosa, R. J. Barlow, M. Barnyakov, S. Barsuk, W. Barter, M. Bartolini, J. Bartz, F. Baryshnikov, J. M. Basels, G. Bassi, B. Batsukh, A. Bay, A. Beck, M. Becker, F. Bedeschi, I. B. Bediaga, S. Belin, V. Bellee, K. Belous, I. Belov, I. Belyaev, G. Benane, G. Bencivenni, E. Ben-Haim, A. Berezhnoy, R. Bernet, S. Bernet Andres, A. Bertolin, C. Betancourt, F. Betti, J. Bex, Ia. Bezshyiko, J. Bhom, M. S. Bieker, N. V. Biesuz, P. Billoir, A. Biolchini, M. Birch, F. C. R. Bishop, A. Bitadze, A. Bizzeti, T. Blake, F. Blanc, J. E. Blank, S. Blusk, V. Bocharnikov, J. A. Boelhauve, O. Boente Garcia, T. Boettcher, A. Bohare, A. Boldyrev, C. S. Bolognani, R. Bolzonella, N. Bondar, F. Borgato, S. Borghi, M. Borsato, J. T. Borsuk, S. A. Bouchiba, T. J. V. Bowcock, A. Boyer, C. Bozzi, M. J. Bradley, A. Brea Rodriguez, N. Breer, J. Brodzicka, A. Brossa Gonzalo, J. Brown, D. Brundu, E. Buchanan, A. Buonaura, L. Buonincontri, A. T. Burke, C. Burr, A. Butkevich, J. S. Butter, J. Buytaert, W. Byczynski, S. Cadeddu, H. Cai, R. Calabrese, S. Calderon Ramirez, L. Calefice, S. Cali, M. Calvi, M. Calvo Gomez, P. Camargo Magalhaes, J. Cambon Bouzas, P. Campana, D. H. Campora Perez, A. F. Campoverde Quezada, S. Capelli, L. Capriotti, R. Caravaca-Mora, A. Carbone, L. Carcedo Salgado, R. Cardinale, A. Cardini, P. Carniti, L. Carus, A. Casais Vidal, R. Caspary, G. Casse, J. Castro Godinez, M. Cattaneo, G. Cavallero, V. Cavallini, S. Celani, D. Cervenkov, S. Cesare, A. J. Chadwick, I. Chahrour, M. Charles, Ph. Charpentier, C. A. Chavez Barajas, M. Chefdeville, C. Chen, S. Chen, Z. Chen, A. Chernov, S. Chernyshenko, V. Chobanova, S. Cholak, M. Chrzaszcz, A. Chubykin, V. Chulikov, P. Ciambrone, X. Cid Vidal, G. Ciezarek, P. Cifra, P. E. L. Clarke, M. Clemencic, H. V. Cliff, J. Closier, C. Cocha Toapaxi, V. Coco, J. Cogan, E. Cogneras, L. Cojocariu, P. Collins, T. Colombo, A. Comerma-Montells, L. Congedo, A. Contu, N. Cooke, I. Corredoira, A. Correia, G. Corti, J. J. Cottee Meldrum, B. Couturier, D. C. Craik, M. Cruz Torres, E. Curras Rivera, R. Currie, C. L. Da Silva, S. Dadabaev, L. Dai, X. Dai, E. Dall’Occo, J. Dalseno, C. D’Ambrosio, J. Daniel, A. Danilina, P. d’Argent, A. Davidson, J. E. Davies, A. Davis, O. De Aguiar Francisco, C. De Angelis, J. de Boer, K. De Bruyn, S. De Capua, M. De Cian, U. De Freitas Carneiro Da Graca, E. De Lucia, J. M. De Miranda, L. De Paula, M. De Serio, P. De Simone, F. De Vellis, J. A. de Vries, F. Debernardis, D. Decamp, V. Dedu, L. Del Buono, B. Delaney, H.-P. Dembinski, J. Deng, V. Denysenko, O. Deschamps, F. Dettori, B. Dey, P. Di Nezza, I. Diachkov, S. Didenko, S. Ding, L. Dittmann, V. Dobishuk, A. D. Docheva, C. Dong, A. M. Donohoe, F. Dordei, A. C. dos Reis, A. D. Dowling, W. Duan, P. Duda, M. W. Dudek, L. Dufour, V. Duk, P. Durante, M. M. Duras, J. M. Durham, O. D. Durmus, A. Dziurda, A. Dzyuba, S. Easo, E. Eckstein, U. Egede, A. Egorychev, V. Egorychev, S. Eisenhardt, E. Ejopu, L. Eklund, M. Elashri, J. Ellbracht, S. Ely, A. Ene, E. Epple, J. Eschle, S. Esen, T. Evans, F. Fabiano, L. N. Falcao, Y. Fan, B. Fang, L. Fantini, M. Faria, K. Farmer, D. Fazzini, L. Felkowski, M. Feng, M. Feo, M. Fernandez Gomez, A. D. Fernez, F. Ferrari, F. Ferreira Rodrigues, M. Ferrillo, M. Ferro-Luzzi, S. Filippov, R. A. Fini, M. Fiorini, K. M. Fischer, D. S. Fitzgerald, C. Fitzpatrick, F. Fleuret, M. Fontana, L. F. Foreman, R. Forty, D. Foulds-Holt, M. Franco Sevilla, M. Frank, E. Franzoso, G. Frau, C. Frei, D. A. Friday, J. Fu, Q. Fuehring, Y. Fujii, T. Fulghesu, E. Gabriel, G. Galati, M. D. Galati, A. Gallas Torreira, D. Galli, S. Gambetta, M. Gandelman, P. Gandini, B. Ganie, H. Gao, R. Gao, Y. Gao, M. Garau, L. M. Garcia Martin, P. Garcia Moreno, J. García Pardiñas, K. G. Garg, L. Garrido, C. Gaspar, R. E. Geertsema, L. L. Gerken, E. Gersabeck, M. Gersabeck, T. Gershon, Z. Ghorbanimoghaddam, L. Giambastiani, F. I. Giasemis, V. Gibson, H. K. Giemza, A. L. Gilman, M. Giovannetti, A. Gioventù, P. Gironella Gironell, C. Giugliano, M. A. Giza, E. L. Gkougkousis, F. C. Glaser, V. V. Gligorov, C. Göbel, E. Golobardes, D. Golubkov, A. Golutvin, A. Gomes, S. Gomez Fernandez, F. Goncalves Abrantes, M. Goncerz, G. Gong, J. A. Gooding, I. V. Gorelov, C. Gotti, J. P. Grabowski, L. A. Granado Cardoso, E. Graugés, E. Graverini, L. Grazette, G. Graziani, A. T. Grecu, L. M. Greeven, N. A. Grieser, L. Grillo, S. Gromov, C. Gu, M. Guarise, M. Guittiere, V. Guliaeva, P. A. Günther, A.-K. Guseinov, E. Gushchin, Y. Guz, T. Gys, K. Habermann, T. Hadavizadeh, C. Hadjivasiliou, G. Haefeli, C. Haen, J. Haimberger, M. Hajheidari, M. M. Halvorsen, P. M. Hamilton, J. Hammerich, Q. Han, X. Han, S. Hansmann-Menzemer, L. Hao, N. Harnew, M. Hartmann, J. He, P. H. Hein Nogarolli Vilela Pereira, F. Hemmer, C. Henderson, R. D. L. Henderson, A. M. Hennequin, K. Hennessy, L. Henry, J. Herd, J. Herdieckerhoff, P. Herrero Gascon, J. Heuel, A. Hicheur, G. Hijano Mendizabal, D. Hill, S. E. Hollitt, J. Horswill, R. Hou, Y. Hou, N. Howarth, J. Hu, W. Hu, X. Hu, W. Huang, W. Hulsbergen, R. J. Hunter, M. Hushchyn, D. Hutchcroft, D. Ilin, P. Ilten, A. Inglessi, A. Iniukhin, A. Ishteev, K. Ivshin, R. Jacobsson, H. Jage, S. J. Jaimes Elles, S. Jakobsen, E. Jans, B. K. Jashal, A. Jawahery, V. Jevtic, E. Jiang, X. Jiang, Y. Jiang, Y. J. Jiang, M. John, D. Johnson, C. R. Jones, T. P. Jones, S. Joshi, B. Jost, N. Jurik, I. Juszczak, D. Kaminaris, S. Kandybei, Y. Kang, C. Kar, M. Karacson, D. Karpenkov, A. M. Kauniskangas, J. W. Kautz, F. Keizer, M. Kenzie, T. Ketel, B. Khanji, A. Kharisova, S. Kholodenko, G. Khreich, T. Kirn, V. S. Kirsebom, O. Kitouni, S. Klaver, N. Kleijne, K. Klimaszewski, M. R. Kmiec, S. Koliiev, L. Kolk, A. Konoplyannikov, P. Kopciewicz, P. Koppenburg, M. Korolev, I. Kostiuk, O. Kot, S. Kotriakhova, A. Kozachuk, P. Kravchenko, L. Kravchuk, M. Kreps, P. Krokovny, W. Krupa, W. Krzemien, O. K. Kshyvanskyi, J. Kubat, S. Kubis, M. Kucharczyk, V. Kudryavtsev, E. Kulikova, A. Kupsc, B. K. Kutsenko, D. Lacarrere, A. Lai, A. Lampis, D. Lancierini, C. Landesa Gomez, J. J. Lane, R. Lane, C. Langenbruch, J. Langer, O. Lantwin, T. Latham, F. Lazzari, C. Lazzeroni, R. Le Gac, R. Lefèvre, A. Leflat, S. Legotin, M. Lehuraux, E. Lemos Cid, O. Leroy, T. Lesiak, B. Leverington, A. Li, H. Li, K. Li, L. Li, P. Li, P.-R. Li, Q. Li, S. Li, T. Li, Y. Li, Z. Lian, X. Liang, S. Libralon, C. Lin, T. Lin, R. Lindner, V. Lisovskyi, R. Litvinov, F. L. Liu, G. Liu, K. Liu, S. Liu, Y. Liu, Y. L. Liu, A. Lobo Salvia, A. Loi, J. Lomba Castro, T. Long, J. H. Lopes, A. Lopez Huertas, S. López Soliño, C. Lucarelli, D. Lucchesi, M. Lucio Martinez, V. Lukashenko, Y. Luo, A. Lupato, E. Luppi, K. Lynch, X.-R. Lyu, G. M. Ma, R. Ma, S. Maccolini, F. Machefert, F. Maciuc, B. M. Mack, I. Mackay, L. M. Mackey, L. R. Madhan Mohan, M. M. Madurai, A. Maevskiy, D. Magdalinski, D. Maisuzenko, M. W. Majewski, J. J. Malczewski, S. Malde, L. Malentacca, A. Malinin, T. Maltsev, G. Manca, G. Mancinelli, C. Mancuso, R. Manera Escalero, D. Manuzzi, D. Marangotto, J. F. Marchand, R. Marchevski, U. Marconi, S. Mariani, C. Marin Benito, J. Marks, A. M. Marshall, G. Martelli, G. Martellotti, L. Martinazzoli, M. Martinelli, D. Martinez Santos, F. Martinez Vidal, A. Massafferri, R. Matev, A. Mathad, V. Matiunin, C. Matteuzzi, K. R. Mattioli, A. Mauri, E. Maurice, J. Mauricio, P. Mayencourt, M. Mazurek, M. McCann, L. Mcconnell, T. H. McGrath, N. T. McHugh, A. McNab, R. McNulty, B. Meadows, G. Meier, D. Melnychuk, F. M. Meng, M. Merk, A. Merli, L. Meyer Garcia, D. Miao, H. Miao, M. Mikhasenko, D. A. Milanes, A. Minotti, E. Minucci, T. Miralles, B. Mitreska, D. S. Mitzel, A. Modak, A. Mödden, R. A. Mohammed, R. D. Moise, S. Mokhnenko, T. Mombächer, M. Monk, S. Monteil, A. Morcillo Gomez, G. Morello, M. J. Morello, M. P. Morgenthaler, A. B. Morris, A. G. Morris, R. Mountain, H. Mu, Z. M. Mu, E. Muhammad, F. Muheim, M. Mulder, K. Müller, F. Muñoz-Rojas, R. Murta, P. Naik, T. Nakada, R. Nandakumar, T. Nanut, I. Nasteva, M. Needham, N. Neri, S. Neubert, N. Neufeld, P. Neustroev, J. Nicolini, D. Nicotra, E. M. Niel, N. Nikitin, P. Nogga, N. S. Nolte, C. Normand, J. Novoa Fernandez, G. Nowak, C. Nunez, H. N. Nur, A. Oblakowska-Mucha, V. Obraztsov, T. Oeser, S. Okamura, A. Okhotnikov, R. Oldeman, F. Oliva, M. Olocco, C. J. G. Onderwater, R. H. O’Neil, J. M. Otalora Goicochea, P. Owen, A. Oyanguren, O. Ozcelik, K. O. Padeken, B. Pagare, P. R. Pais, T. Pajero, A. Palano, M. Palutan, G. Panshin, L. Paolucci, A. Papanestis, M. Pappagallo, L. L. Pappalardo, C. Pappenheimer, C. Parkes, B. Passalacqua, G. Passaleva, D. Passaro, A. Pastore, M. Patel, J. Patoc, C. Patrignani, A. Paul, C. J. Pawley, A. Pellegrino, J. Peng, M. Pepe Altarelli, S. Perazzini, D. Pereima, A. Pereiro Castro, P. Perret, A. Perro, K. Petridis, A. Petrolini, J. P. Pfaller, H. Pham, L. Pica, M. Piccini, B. Pietrzyk, G. Pietrzyk, D. Pinci, F. Pisani, M. Pizzichemi, V. Placinta, M. Plo Casasus, F. Polci, M. Poli Lener, A. Poluektov, N. Polukhina, I. Polyakov, E. Polycarpo, S. Ponce, D. Popov, S. Poslavskii, K. Prasanth, C. Prouve, V. Pugatch, G. Punzi, S. Qasim, W. Qian, N. Qin, S. Qu, R. Quagliani, R. I. Rabadan Trejo, J. H. Rademacker, M. Rama, M. Ramírez García, M. Ramos Pernas, M. S. Rangel, F. Ratnikov, G. Raven, M. Rebollo De Miguel, F. Redi, J. Reich, F. Reiss, Z. Ren, P. K. Resmi, R. Ribatti, G. R. Ricart, D. Riccardi, S. Ricciardi, K. Richardson, M. Richardson-Slipper, K. Rinnert, P. Robbe, G. Robertson, E. Rodrigues, E. Rodriguez Fernandez, J. A. Rodriguez Lopez, E. Rodriguez Rodriguez, A. Rogovskiy, D. L. Rolf, P. Roloff, V. Romanovskiy, M. Romero Lamas, A. Romero Vidal, G. Romolini, F. Ronchetti, M. Rotondo, S. R. Roy, M. S. Rudolph, T. Ruf, M. Ruiz Diaz, R. A. Ruiz Fernandez, J. Ruiz Vidal, A. Ryzhikov, J. Ryzka, J. J. Saavedra-Arias, J. J. Saborido Silva, R. Sadek, N. Sagidova, D. Sahoo, N. Sahoo, B. Saitta, M. Salomoni, C. Sanchez Gras, I. Sanderswood, R. Santacesaria, C. Santamarina Rios, M. Santimaria, L. Santoro, E. Santovetti, A. Saputi, D. Saranin, G. Sarpis, M. Sarpis, C. Satriano, A. Satta, M. Saur, D. Savrina, H. Sazak, L. G. Scantlebury Smead, A. Scarabotto, S. Schael, S. Scherl, M. Schiller, H. Schindler, M. Schmelling, B. Schmidt, S. Schmitt, H. Schmitz, O. Schneider, A. Schopper, N. Schulte, S. Schulte, M. H. Schune, R. Schwemmer, G. Schwering, B. Sciascia, A. Sciuccati, S. Sellam, A. Semennikov, T. Senger, M. Senghi Soares, A. Sergi, N. Serra, L. Sestini, A. Seuthe, Y. Shang, D. M. Shangase, M. Shapkin, R. S. Sharma, I. Shchemerov, L. Shchutska, T. Shears, L. Shekhtman, Z. Shen, S. Sheng, V. Shevchenko, B. Shi, Q. Shi, E. B. Shields, Y. Shimizu, E. Shmanin, R. Shorkin, J. D. Shupperd, R. Silva Coutinho, G. Simi, S. Simone, N. Skidmore, T. Skwarnicki, M. W. Slater, J. C. Smallwood, E. Smith, K. Smith, M. Smith, A. Snoch, L. Soares Lavra, M. D. Sokoloff, F. J. P. Soler, A. Solomin, A. Solovev, I. Solovyev, R. Song, Y. Song, Y. S. Song, F. L. Souza De Almeida, B. Souza De Paula, E. Spadaro Norella, E. Spedicato, J. G. Speer, E. Spiridenkov, P. Spradlin, V. Sriskaran, F. Stagni, M. Stahl, S. Stahl, S. Stanislaus, E. N. Stein, O. Steinkamp, O. Stenyakin, H. Stevens, D. Strekalina, Y. Su, F. Suljik, J. Sun, L. Sun, Y. Sun, D. S. Sundfeld Lima, W. Sutcliffe, P. N. Swallow, F. Swystun, A. Szabelski, T. Szumlak, Y. Tan, M. D. Tat, A. Terentev, F. Terzuoli, F. Teubert, E. Thomas, D. J. D. Thompson, H. Tilquin, V. Tisserand, S. T’Jampens, M. Tobin, L. Tomassetti, G. Tonani, X. Tong, D. Torres Machado, L. Toscano, D. Y. Tou, C. Trippl, G. Tuci, N. Tuning, L. H. Uecker, A. Ukleja, D. J. Unverzagt, E. Ursov, A. Usachov, A. Ustyuzhanin, U. Uwer, V. Vagnoni, A. Valassi, G. Valenti, N. Valls Canudas, H. Van Hecke, E. van Herwijnen, C. B. Van Hulse, R. Van Laak, M. van Veghel, G. Vasquez, R. Vazquez Gomez, P. Vazquez Regueiro, C. Vázquez Sierra, S. Vecchi, J. J. Velthuis, M. Veltri, A. Venkateswaran, M. Vesterinen, M. Vieites Diaz, X. Vilasis-Cardona, E. Vilella Figueras, A. Villa, P. Vincent, F. C. Volle, D. vom Bruch, N. Voropaev, K. Vos, G. Vouters, C. Vrahas, J. Walsh, E. J. Walton, G. Wan, C. Wang, G. Wang, J. Wang, M. Wang, N. W. Wang, R. Wang, X. Wang, X. W. Wang, Z. Wang, J. A. Ward, M. Waterlaat, N. K. Watson, D. Websdale, Y. Wei, J. Wendel, B. D. C. Westhenry, D. J. White, M. Whitehead, A. R. Wiederhold, D. Wiedner, G. Wilkinson, M. K. Wilkinson, M. Williams, M. R. J. Williams, R. Williams, F. F. Wilson, W. Wislicki, M. Witek, L. Witola, C. P. Wong, G. Wormser, S. A. Wotton, H. Wu, J. Wu, Y. Wu, K. Wyllie, S. Xian, Z. Xiang, Y. Xie, A. Xu, J. Xu, L. Xu, M. Xu, Z. Xu, D. Yang, S. Yang, X. Yang, Y. Yang, Z. Yang, V. Yeroshenko, H. Yeung, H. Yin, C. Y. Yu, J. Yu, X. Yuan, E. Zaffaroni, M. Zavertyaev, M. Zdybal, C. Zeng, M. Zeng, C. Zhang, D. Zhang, J. Zhang, L. Zhang, S. Zhang, Y. Zhang, Y. Z. Zhang, Y. Zhao, A. Zharkova, A. Zhelezov, X. Z. Zheng, Y. Zheng, T. Zhou, X. Zhou, Y. Zhou, V. Zhovkovska, L. Z. Zhu, X. Zhu, V. Zhukov, J. Zhuo, Q. Zou, D. Zuliani, and G. Zunica
Subjects: Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract: Abstract A method is presented to reconstruct charged particles with lifetimes between $$10\,\text {ps} $$ 10 ps and $$10\,\text {ns},$$ 10 ns , which considers a combination of their decay products and the partial tracks created by the initial charged particle. Using the $${\varXi } ^- $$ Ξ - baryon as a benchmark, the method is demonstrated with simulated events and proton-proton collision data at $$\sqrt{s} =13\,\text {TeV},$$ s = 13 TeV , corresponding to an integrated luminosity of 2.0 $$\,\text {fb} ^{-1}$$ fb - 1 collected with the LHCb detector in 2018. Significant improvements in the angular resolution and the signal purity are obtained. The method is implemented as part of the LHCb Run 3 event trigger in a set of requirements to select detached hyperons. This is the first demonstration of the applicability of this approach at the LHC, and the first to show its scaling with instantaneous luminosity.
Published: 2024
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25. Diabetes Telemedicine Mediterranean Diet (DiaTeleMed) Study: study protocol for a fully remote randomized clinical trial evaluating personalized dietary management in individuals with type 2 diabetes

Author: Lauren T. Berube, Collin J. Popp, Margaret Curran, Lu Hu, Mary Lou Pompeii, Souptik Barua, Emma Bernstein, Vanessa Salcedo, Huilin Li, David E. St-Jules, Eran Segal, Michael Bergman, Natasha J. Williams, and Mary Ann Sevick
Subjects: Precision nutrition, Glycemic variability, Continuous glucose monitors, Dysglycemia, Remote patient monitoring, Randomized clinical trial, Medicine (General), R5-920
Abstract: Abstract Background The Diabetes Telemedicine Mediterranean Diet (DiaTeleMed) Study is a fully remote randomized clinical trial evaluating personalized dietary management in individuals with type 2 diabetes (T2D). The study aims to test the efficacy of a personalized behavioral approach for dietary management of moderately controlled T2D, versus a standardized behavioral intervention that uses one-size-fits-all dietary recommendations, versus a usual care control (UCC). The primary outcome will compare the impact of each intervention on the mean amplitude of glycemic excursions (MAGE). Methods Eligible participants are between 21 and 80 years of age diagnosed with moderately controlled T2D (HbA1c: 6.0 to 8.0%) and managed on lifestyle alone or lifestyle plus metformin. Participants must be willing and able to attend virtual counseling sessions and log meals into a dietary tracking smartphone application (DayTwo), and wear a continuous glucose monitor (CGM) for up to 12 days. Participants are randomized with equal allocation (n = 255, n = 85 per arm) to one of three arms: (1) Personalized, (2) Standardized, or (3) UCC. Measurements occur at 0 (baseline), 3, and 6 months. All participants receive isocaloric energy and macronutrient targets to meet Mediterranean diet guidelines, in addition to 14 intervention contacts over 6 months (4 weekly then 10 biweekly) to cover diabetes self-management education. The first 4 UCC intervention contacts are delivered via synchronous videoconferences followed by educational video links. Participants in Standardized receive the same educational content as those in the UCC arm, following the same schedule. However, all intervention contacts are conducted via synchronous videoconferences, paired with Social Cognitive Theory (SCT)-based behavioral counseling, plus dietary self-monitoring of planned meals using a mobile app that provides real-time feedback on calories and macronutrients. Participants in the Personalized arm receive all elements of the Standardized intervention, in addition to real-time feedback on predicted post-prandial glycemic response (PPGR) to meals and snacks logged into the mobile app. Discussion The DiaTeleMed Study aims to address an important gap in the current landscape of precision nutrition by determining the contributions of behavioral counseling and personalized nutrition recommendations on glycemic control in individuals with T2D. The fully remote methodology of the study allows for scalability and innovative delivery of personalized dietary recommendations at a population level. Trial registration ClinicalTrials.gov NCT05046886. Registered on September 16, 2021.
Published: 2024
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26. First observation of the Λ b 0 $$ {\Lambda}_b^0 $$ → D + D − Λ decay

Author: The LHCb collaboration, R. Aaij, A. S. W. Abdelmotteleb, C. Abellan Beteta, F. Abudinén, T. Ackernley, J. A. Adams, A. A. Adefisoye, B. Adeva, M. Adinolfi, P. Adlarson, C. Agapopoulou, C. A. Aidala, Z. Ajaltouni, S. Akar, K. Akiba, P. Albicocco, J. Albrecht, F. Alessio, M. Alexander, Z. Aliouche, P. Alvarez Cartelle, R. Amalric, S. Amato, J. L. Amey, Y. Amhis, L. An, L. Anderlini, M. Andersson, A. Andreianov, P. Andreola, M. Andreotti, D. Andreou, A. Anelli, D. Ao, F. Archilli, M. Argenton, S. Arguedas Cuendis, A. Artamonov, M. Artuso, E. Aslanides, M. Atzeni, B. Audurier, D. Bacher, I. Bachiller Perea, S. Bachmann, M. Bachmayer, J. J. Back, P. Baladron Rodriguez, V. Balagura, W. Baldini, J. Baptista de Souza Leite, M. Barbetti, I. R. Barbosa, R. J. Barlow, S. Barsuk, W. Barter, M. Bartolini, J. Bartz, F. Baryshnikov, J. M. Basels, G. Bassi, B. Batsukh, A. Battig, A. Bay, A. Beck, M. Becker, F. Bedeschi, I. B. Bediaga, A. Beiter, S. Belin, V. Bellee, K. Belous, I. Belov, I. Belyaev, G. Benane, G. Bencivenni, E. Ben-Haim, A. Berezhnoy, R. Bernet, S. Bernet Andres, C. Bertella, A. Bertolin, C. Betancourt, F. Betti, J. Bex, Ia. Bezshyiko, J. Bhom, M. S. Bieker, N. V. Biesuz, P. Billoir, A. Biolchini, M. Birch, F. C. R. Bishop, A. Bitadze, A. Bizzeti, T. Blake, F. Blanc, J. E. Blank, S. Blusk, V. Bocharnikov, J. A. Boelhauve, O. Boente Garcia, T. Boettcher, A. Bohare, A. Boldyrev, C. S. Bolognani, R. Bolzonella, N. Bondar, F. Borgato, S. Borghi, M. Borsato, J. T. Borsuk, S. A. Bouchiba, T. J. V. Bowcock, A. Boyer, C. Bozzi, M. J. Bradley, A. Brea Rodriguez, N. Breer, J. Brodzicka, A. Brossa Gonzalo, J. Brown, D. Brundu, E. Buchanan, A. Buonaura, L. Buonincontri, A. T. Burke, C. Burr, A. Bursche, A. Butkevich, J. S. Butter, J. Buytaert, W. Byczynski, S. Cadeddu, H. Cai, R. Calabrese, L. Calefice, S. Cali, M. Calvi, M. Calvo Gomez, J. I. Cambon Bouzas, P. Campana, D. H. Campora Perez, A. F. Campoverde Quezada, S. Capelli, L. Capriotti, R. Caravaca-Mora, A. Carbone, L. Carcedo Salgado, R. Cardinale, A. Cardini, P. Carniti, L. Carus, A. Casais Vidal, R. Caspary, G. Casse, J. Castro Godinez, M. Cattaneo, G. Cavallero, V. Cavallini, S. Celani, J. Cerasoli, D. Cervenkov, S. Cesare, A. J. Chadwick, I. Chahrour, M. Charles, Ph. Charpentier, C. A. Chavez Barajas, M. Chefdeville, C. Chen, S. Chen, Z. Chen, A. Chernov, S. Chernyshenko, V. Chobanova, S. Cholak, M. Chrzaszcz, A. Chubykin, V. Chulikov, P. Ciambrone, X. Cid Vidal, G. Ciezarek, P. Cifra, P. E. L. Clarke, M. Clemencic, H. V. Cliff, J. Closier, C. Cocha Toapaxi, V. Coco, J. Cogan, E. Cogneras, L. Cojocariu, P. Collins, T. Colombo, A. Comerma-Montells, L. Congedo, A. Contu, N. Cooke, I. Corredoira, A. Correia, G. Corti, J. J. Cottee Meldrum, B. Couturier, D. C. Craik, M. Cruz Torres, E. Curras Rivera, R. Currie, C. L. Da Silva, S. Dadabaev, L. Dai, X. Dai, E. Dall’Occo, J. Dalseno, C. D’Ambrosio, J. Daniel, A. Danilina, P. d’Argent, A. Davidson, J. E. Davies, A. Davis, O. De Aguiar Francisco, C. De Angelis, F. De Benedetti, J. de Boer, K. De Bruyn, S. De Capua, M. De Cian, U. De Freitas Carneiro Da Graca, E. De Lucia, J. M. De Miranda, L. De Paula, M. De Serio, D. De Simone, P. De Simone, F. De Vellis, J. A. de Vries, F. Debernardis, D. Decamp, V. Dedu, L. Del Buono, B. Delaney, H.-P. Dembinski, J. Deng, V. Denysenko, O. Deschamps, F. Dettori, B. Dey, P. Di Nezza, I. Diachkov, S. Didenko, S. Ding, L. Dittmann, V. Dobishuk, A. D. Docheva, A. Dolmatov, C. Dong, A. M. Donohoe, F. Dordei, A. C. dos Reis, A. D. Dowling, A. G. Downes, W. Duan, P. Duda, M. W. Dudek, L. Dufour, V. Duk, P. Durante, M. M. Duras, J. M. Durham, O. D. Durmus, A. Dziurda, A. Dzyuba, S. Easo, E. Eckstein, U. Egede, A. Egorychev, V. Egorychev, S. Eisenhardt, E. Ejopu, S. Ek-In, L. Eklund, M. Elashri, J. Ellbracht, S. Ely, A. Ene, E. Epple, S. Escher, J. Eschle, S. Esen, T. Evans, F. Fabiano, L. N. Falcao, Y. Fan, B. Fang, L. Fantini, M. Faria, K. Farmer, D. Fazzini, L. Felkowski, M. Feng, M. Feo, M. Fernandez Gomez, A. D. Fernez, F. Ferrari, F. Ferreira Rodrigues, S. Ferreres Sole, M. Ferrillo, M. Ferro-Luzzi, S. Filippov, R. A. Fini, M. Fiorini, K. M. Fischer, D. S. Fitzgerald, C. Fitzpatrick, F. Fleuret, M. Fontana, L. F. Foreman, R. Forty, D. Foulds-Holt, M. Franco Sevilla, M. Frank, E. Franzoso, G. Frau, C. Frei, D. A. Friday, J. Fu, Q. Fuehring, Y. Fujii, T. Fulghesu, E. Gabriel, G. Galati, M. D. Galati, A. Gallas Torreira, D. Galli, S. Gambetta, M. Gandelman, P. Gandini, H. Gao, R. Gao, Y. Gao, M. Garau, L. M. Garcia Martin, P. Garcia Moreno, J. García Pardiñas, K. G. Garg, L. Garrido, C. Gaspar, R. E. Geertsema, L. L. Gerken, E. Gersabeck, M. Gersabeck, T. Gershon, Z. Ghorbanimoghaddam, L. Giambastiani, F. I. Giasemis, V. Gibson, H. K. Giemza, A. L. Gilman, M. Giovannetti, A. Gioventù, P. Gironella Gironell, C. Giugliano, M. A. Giza, E. L. Gkougkousis, F. C. Glaser, V. V. Gligorov, C. Göbel, E. Golobardes, D. Golubkov, A. Golutvin, A. Gomes, S. Gomez Fernandez, F. Goncalves Abrantes, M. Goncerz, G. Gong, J. A. Gooding, I. V. Gorelov, C. Gotti, J. P. Grabowski, L. A. Granado Cardoso, E. Graugés, E. Graverini, L. Grazette, G. Graziani, A. T. Grecu, L. M. Greeven, N. A. Grieser, L. Grillo, S. Gromov, C. Gu, M. Guarise, M. Guittiere, V. Guliaeva, P. A. Günther, A.-K. Guseinov, E. Gushchin, Y. Guz, T. Gys, K. Habermann, T. Hadavizadeh, C. Hadjivasiliou, G. Haefeli, C. Haen, J. Haimberger, M. Hajheidari, M. M. Halvorsen, P. M. Hamilton, J. Hammerich, Q. Han, X. Han, S. Hansmann-Menzemer, L. Hao, N. Harnew, T. Harrison, M. Hartmann, J. He, K. Heijhoff, F. Hemmer, C. Henderson, R. D. L. Henderson, A. M. Hennequin, K. Hennessy, L. Henry, J. Herd, P. Herrero Gascon, J. Heuel, A. Hicheur, G. Hijano Mendizabal, D. Hill, S. E. Hollitt, J. Horswill, R. Hou, Y. Hou, N. Howarth, J. Hu, W. Hu, X. Hu, W. Huang, W. Hulsbergen, R. J. Hunter, M. Hushchyn, D. Hutchcroft, D. Ilin, P. Ilten, A. Inglessi, A. Iniukhin, A. Ishteev, K. Ivshin, R. Jacobsson, H. Jage, S. J. Jaimes Elles, S. Jakobsen, E. Jans, B. K. Jashal, A. Jawahery, V. Jevtic, E. Jiang, X. Jiang, Y. Jiang, Y. J. Jiang, M. John, D. Johnson, C. R. Jones, T. P. Jones, S. Joshi, B. Jost, N. Jurik, I. Juszczak, D. Kaminaris, S. Kandybei, Y. Kang, M. Karacson, D. Karpenkov, A. Kauniskangas, J. W. Kautz, F. Keizer, M. Kenzie, T. Ketel, B. Khanji, A. Kharisova, S. Kholodenko, G. Khreich, T. Kirn, V. S. Kirsebom, O. Kitouni, S. Klaver, N. Kleijne, K. Klimaszewski, M. R. Kmiec, S. Koliiev, L. Kolk, A. Konoplyannikov, P. Kopciewicz, P. Koppenburg, M. Korolev, I. Kostiuk, O. Kot, S. Kotriakhova, A. Kozachuk, P. Kravchenko, L. Kravchuk, M. Kreps, S. Kretzschmar, P. Krokovny, W. Krupa, W. Krzemien, J. Kubat, S. Kubis, W. Kucewicz, M. Kucharczyk, V. Kudryavtsev, E. Kulikova, A. Kupsc, B. K. Kutsenko, D. Lacarrere, A. Lai, A. Lampis, D. Lancierini, C. Landesa Gomez, J. J. Lane, R. Lane, C. Langenbruch, J. Langer, O. Lantwin, T. Latham, F. Lazzari, C. Lazzeroni, R. Le Gac, R. Lefèvre, A. Leflat, S. Legotin, M. Lehuraux, E. Lemos Cid, O. Leroy, T. Lesiak, B. Leverington, A. Li, H. Li, K. Li, L. Li, P. Li, P.-R. Li, S. Li, T. Li, Y. Li, Z. Li, Z. Lian, X. Liang, S. Libralon, C. Lin, T. Lin, R. Lindner, V. Lisovskyi, R. Litvinov, F. L. Liu, G. Liu, K. Liu, Q. Liu, S. Liu, Y. Liu, Y. L. Liu, A. Lobo Salvia, A. Loi, J. Lomba Castro, T. Long, J. H. Lopes, A. Lopez Huertas, S. López Soliño, G. H. Lovell, C. Lucarelli, D. Lucchesi, S. Luchuk, M. Lucio Martinez, V. Lukashenko, Y. Luo, A. Lupato, E. Luppi, K. Lynch, X.-R. Lyu, G. M. Ma, R. Ma, S. Maccolini, F. Machefert, F. Maciuc, B. M. Mack, I. Mackay, L. M. Mackey, L. R. Madhan Mohan, M. M. Madurai, A. Maevskiy, D. Magdalinski, D. Maisuzenko, M. W. Majewski, J. J. Malczewski, S. Malde, B. Malecki, L. Malentacca, A. Malinin, T. Maltsev, G. Manca, G. Mancinelli, C. Mancuso, R. Manera Escalero, D. Manuzzi, D. Marangotto, J. F. Marchand, R. Marchevski, U. Marconi, S. Mariani, C. Marin Benito, J. Marks, A. M. Marshall, P. J. Marshall, G. Martelli, G. Martellotti, L. Martinazzoli, M. Martinelli, D. Martinez Santos, F. Martinez Vidal, A. Massafferri, M. Materok, R. Matev, A. Mathad, V. Matiunin, C. Matteuzzi, K. R. Mattioli, A. Mauri, E. Maurice, J. Mauricio, P. Mayencourt, M. Mazurek, M. McCann, L. Mcconnell, T. H. McGrath, N. T. McHugh, A. McNab, R. McNulty, B. Meadows, G. Meier, D. Melnychuk, M. Merk, A. Merli, L. Meyer Garcia, D. Miao, H. Miao, M. Mikhasenko, D. A. Milanes, A. Minotti, E. Minucci, T. Miralles, B. Mitreska, D. S. Mitzel, A. Modak, A. Mödden, R. A. Mohammed, R. D. Moise, S. Mokhnenko, T. Mombächer, M. Monk, S. Monteil, A. Morcillo Gomez, G. Morello, M. J. Morello, M. P. Morgenthaler, A. B. Morris, A. G. Morris, R. Mountain, H. Mu, Z. M. Mu, E. Muhammad, F. Muheim, M. Mulder, K. Müller, F. Muñoz-Rojas, R. Murta, P. Naik, T. Nakada, R. Nandakumar, T. Nanut, I. Nasteva, M. Needham, N. Neri, S. Neubert, N. Neufeld, P. Neustroev, J. Nicolini, D. Nicotra, E. M. Niel, N. Nikitin, P. Nogga, N. S. Nolte, C. Normand, J. Novoa Fernandez, G. Nowak, C. Nunez, H. N. Nur, A. Oblakowska-Mucha, V. Obraztsov, T. Oeser, S. Okamura, A. Okhotnikov, R. Oldeman, F. Oliva, M. Olocco, C. J. G. Onderwater, R. H. O’Neil, J. M. Otalora Goicochea, P. Owen, A. Oyanguren, O. Ozcelik, K. O. Padeken, B. Pagare, P. R. Pais, T. Pajero, A. Palano, M. Palutan, G. Panshin, L. Paolucci, A. Papanestis, M. Pappagallo, L. L. Pappalardo, C. Pappenheimer, C. Parkes, B. Passalacqua, G. Passaleva, D. Passaro, A. Pastore, M. Patel, J. Patoc, C. Patrignani, C. J. Pawley, A. Pellegrino, M. Pepe Altarelli, S. Perazzini, D. Pereima, A. Pereiro Castro, P. Perret, A. Perro, K. Petridis, A. Petrolini, S. Petrucci, J. P. Pfaller, H. Pham, L. Pica, M. Piccini, B. Pietrzyk, G. Pietrzyk, D. Pinci, F. Pisani, M. Pizzichemi, V. Placinta, M. Plo Casasus, F. Polci, M. Poli Lener, A. Poluektov, N. Polukhina, I. Polyakov, E. Polycarpo, S. Ponce, D. Popov, S. Poslavskii, K. Prasanth, C. Prouve, V. Pugatch, G. Punzi, W. Qian, N. Qin, S. Qu, R. Quagliani, R. I. Rabadan Trejo, J. H. Rademacker, M. Rama, M. Ramírez García, M. Ramos Pernas, M. S. Rangel, F. Ratnikov, G. Raven, M. Rebollo De Miguel, F. Redi, J. Reich, F. Reiss, Z. Ren, P. K. Resmi, R. Ribatti, G. R. Ricart, D. Riccardi, S. Ricciardi, K. Richardson, M. Richardson-Slipper, K. Rinnert, P. Robbe, G. Robertson, E. Rodrigues, E. Rodriguez Fernandez, J. A. Rodriguez Lopez, E. Rodriguez Rodriguez, A. Rogovskiy, D. L. Rolf, P. Roloff, V. Romanovskiy, M. Romero Lamas, A. Romero Vidal, G. Romolini, F. Ronchetti, M. Rotondo, S. R. Roy, M. S. Rudolph, T. Ruf, M. Ruiz Diaz, R. A. Ruiz Fernandez, J. Ruiz Vidal, A. Ryzhikov, J. Ryzka, J. J. Saavedra-Arias, J. J. Saborido Silva, R. Sadek, N. Sagidova, D. Sahoo, N. Sahoo, B. Saitta, M. Salomoni, C. Sanchez Gras, I. Sanderswood, R. Santacesaria, C. Santamarina Rios, M. Santimaria, L. Santoro, E. Santovetti, A. Saputi, D. Saranin, G. Sarpis, M. Sarpis, A. Sarti, C. Satriano, A. Satta, M. Saur, D. Savrina, H. Sazak, L. G. Scantlebury Smead, A. Scarabotto, S. Schael, S. Scherl, A. M. Schertz, M. Schiller, H. Schindler, M. Schmelling, B. Schmidt, S. Schmitt, H. Schmitz, O. Schneider, A. Schopper, N. Schulte, S. Schulte, M. H. Schune, R. Schwemmer, G. Schwering, B. Sciascia, A. Sciuccati, S. Sellam, A. Semennikov, T. Senger, M. Senghi Soares, A. Sergi, N. Serra, L. Sestini, A. Seuthe, Y. Shang, D. M. Shangase, M. Shapkin, R. S. Sharma, I. Shchemerov, L. Shchutska, T. Shears, L. Shekhtman, Z. Shen, S. Sheng, V. Shevchenko, B. Shi, E. B. Shields, Y. Shimizu, E. Shmanin, R. Shorkin, J. D. Shupperd, R. Silva Coutinho, G. Simi, S. Simone, N. Skidmore, T. Skwarnicki, M. W. Slater, J. C. Smallwood, E. Smith, K. Smith, M. Smith, A. Snoch, L. Soares Lavra, M. D. Sokoloff, F. J. P. Soler, A. Solomin, A. Solovev, I. Solovyev, R. Song, Y. Song, Y. S. Song, F. L. Souza De Almeida, B. Souza De Paula, E. Spadaro Norella, E. Spedicato, J. G. Speer, E. Spiridenkov, P. Spradlin, V. Sriskaran, F. Stagni, M. Stahl, S. Stahl, S. Stanislaus, E. N. Stein, O. Steinkamp, O. Stenyakin, H. Stevens, D. Strekalina, Y. Su, F. Suljik, J. Sun, L. Sun, Y. Sun, W. Sutcliffe, P. N. Swallow, F. Swystun, A. Szabelski, T. Szumlak, Y. Tan, S. Taneja, M. D. Tat, A. Terentev, F. Terzuoli, F. Teubert, E. Thomas, D. J. D. Thompson, H. Tilquin, V. Tisserand, S. T’Jampens, M. Tobin, L. Tomassetti, G. Tonani, X. Tong, D. Torres Machado, L. Toscano, D. Y. Tou, C. Trippl, G. Tuci, N. Tuning, L. H. Uecker, A. Ukleja, D. J. Unverzagt, E. Ursov, A. Usachov, A. Ustyuzhanin, U. Uwer, V. Vagnoni, A. Valassi, G. Valenti, N. Valls Canudas, H. Van Hecke, E. van Herwijnen, C. B. Van Hulse, R. Van Laak, M. van Veghel, R. Vazquez Gomez, P. Vazquez Regueiro, C. Vázquez Sierra, S. Vecchi, J. J. Velthuis, M. Veltri, A. Venkateswaran, M. Vesterinen, M. Vieites Diaz, X. Vilasis-Cardona, E. Vilella Figueras, A. Villa, P. Vincent, F. C. Volle, D. vom Bruch, V. Vorobyev, N. Voropaev, K. Vos, G. Vouters, C. Vrahas, J. Wagner, J. Walsh, E. J. Walton, G. Wan, C. Wang, G. Wang, J. Wang, M. Wang, N. W. Wang, R. Wang, X. Wang, X. W. Wang, Y. Wang, Z. Wang, J. A. Ward, M. Waterlaat, N. K. Watson, D. Websdale, Y. Wei, B. D. C. Westhenry, D. J. White, M. Whitehead, A. R. Wiederhold, D. Wiedner, G. Wilkinson, M. K. Wilkinson, M. Williams, M. R. J. Williams, R. Williams, F. F. Wilson, W. Wislicki, M. Witek, L. Witola, C. P. Wong, G. Wormser, S. A. Wotton, H. Wu, J. Wu, Y. Wu, K. Wyllie, S. Xian, Z. Xiang, Y. Xie, A. Xu, J. Xu, L. Xu, M. Xu, Z. Xu, D. Yang, S. Yang, X. Yang, Y. Yang, Z. Yang, V. Yeroshenko, H. Yeung, H. Yin, C. Y. Yu, J. Yu, X. Yuan, E. Zaffaroni, M. Zavertyaev, M. Zdybal, M. Zeng, C. Zhang, D. Zhang, J. Zhang, L. Zhang, S. Zhang, Y. Zhang, Y. Z. Zhang, Y. Zhao, A. Zharkova, A. Zhelezov, X. Z. Zheng, Y. Zheng, T. Zhou, X. Zhou, Y. Zhou, V. Zhovkovska, L. Z. Zhu, X. Zhu, V. Zhukov, J. Zhuo, Q. Zou, D. Zuliani, and G. Zunica
Subjects: B Physics, Branching fraction, Flavour Physics, Hadron-Hadron Scattering, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract: Abstract The Λ b 0 $$ {\Lambda}_b^0 $$ → D + D − Λ decay is observed for the first time using proton-proton collision data collected by the LHCb experiment at a center-of-mass energy of 13 TeV, corresponding to an integrated luminosity of 5.3 fb −1. Using the B 0 → D + D − K S 0 $$ {D}^{+}{D}^{-}{K}_S^0 $$ decay as a reference channel, the product of the relative production cross-section and decay branching fractions is measured to be R = σ Λ b 0 σ B 0 = B Λ b 0 → D + D − Λ B B 0 → D + D − K S 0 = 0.179 ± 0.022 ± 0.014 , $$ \mathcal{R}=\frac{\sigma_{\Lambda_b^0}}{\sigma_{B^0}}=\frac{\mathcal{B}\left({\Lambda}_b^0\to {D}^{+}{D}^{-}\Lambda \right)}{\mathcal{B}\left({B}^0\to {D}^{+}{D}^{-}{K}_{\textrm{S}}^0\right)}=0.179\pm 0.022\pm 0.014, $$ where the first uncertainty is statistical and the second is systematic. The known branching fraction of the reference channel, B B 0 → D + D − K S 0 $$ \mathcal{B}\left({B}^0\to {D}^{+}{D}^{-}{K}_{\textrm{S}}^0\right) $$ , and the cross-section ratio, σ Λ b 0 / σ B 0 $$ {\sigma}_{\Lambda_b^0}/{\sigma}_{B^0} $$ , previously measured by LHCb are used to derive the branching fraction of the Λ b 0 $$ {\Lambda}_b^0 $$ → D + D − Λ decay B Λ b 0 → D + D − Λ = 1.24 ± 0.15 ± 0.10 ± 0.28 ± 0.11 × 10 − 4 , $$ \mathcal{B}\left({\Lambda}_b^0\to {D}^{+}{D}^{-}\Lambda \right)=\left(1.24\pm 0.15\pm 0.10\pm 0.28\pm 0.11\right)\times {10}^{-4}, $$ where the third and fourth contributions are due to uncertainties of B B 0 → D + D − K S 0 $$ \mathcal{B}\left({B}^0\to {D}^{+}{D}^{-}{K}_{\textrm{S}}^0\right) $$ and σ Λ b 0 / σ B 0 $$ {\sigma}_{\Lambda_b^0}/{\sigma}_{B^0} $$ , respectively. Inspection of the D +Λ and D + D − invariant-mass distributions suggests a rich presence of intermediate resonances in the decay. The Λ b 0 $$ {\Lambda}_b^0 $$ → D *+ D − Λ decay is also observed for the first time as a partially reconstructed component in the D + D − Λ invariant mass spectrum.
Published: 2024
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27. Single-cell decoding of drug induced transcriptomic reprogramming in triple negative breast cancers

Author: Farhia Kabeer, Hoa Tran, Mirela Andronescu, Gurdeep Singh, Hakwoo Lee, Sohrab Salehi, Beixi Wang, Justina Biele, Jazmine Brimhall, David Gee, Viviana Cerda, Ciara O’Flanagan, Teresa Algara, Takako Kono, Sean Beatty, Elena Zaikova, Daniel Lai, Eric Lee, Richard Moore, Andrew J. Mungall, IMAXT Consortium, Marc J. Williams, Andrew Roth, Kieran R. Campbell, Sohrab P. Shah, and Samuel Aparicio
Subjects: PDX, Single-cell RNA sequencing, DLP+ single-cell sequencing, Cisplatin treatment, In-cis/in-trans genes, Sensitive/resistant clones, Biology (General), QH301-705.5, Genetics, QH426-470
Abstract: Abstract Background The encoding of cell intrinsic drug resistance states in breast cancer reflects the contributions of genomic and non-genomic variations and requires accurate estimation of clonal fitness from co-measurement of transcriptomic and genomic data. Somatic copy number (CN) variation is the dominant mutational mechanism leading to transcriptional variation and notably contributes to platinum chemotherapy resistance cell states. Here, we deploy time series measurements of triple negative breast cancer (TNBC) single-cell transcriptomes, along with co-measured single-cell CN fitness, identifying genomic and transcriptomic mechanisms in drug-associated transcriptional cell states. Results We present scRNA-seq data (53,641 filtered cells) from serial passaging TNBC patient-derived xenograft (PDX) experiments spanning 2.5 years, matched with genomic single-cell CN data from the same samples. Our findings reveal distinct clonal responses within TNBC tumors exposed to platinum. Clones with high drug fitness undergo clonal sweeps and show subtle transcriptional reversion, while those with weak fitness exhibit dynamic transcription upon drug withdrawal. Pathway analysis highlights convergence on epithelial-mesenchymal transition and cytokine signaling, associated with resistance. Furthermore, pseudotime analysis demonstrates hysteresis in transcriptional reversion, indicating generation of new intermediate transcriptional states upon platinum exposure. Conclusions Within a polyclonal tumor, clones with strong genotype-associated fitness under platinum remained fixed, minimizing transcriptional reversion upon drug withdrawal. Conversely, clones with weaker fitness display non-genomic transcriptional plasticity. This suggests CN-associated and CN-independent transcriptional states could both contribute to platinum resistance. The dominance of genomic or non-genomic mechanisms within polyclonal tumors has implications for drug sensitivity, restoration, and re-treatment strategies.
Published: 2024
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28. Central Nervous System Prophylaxis Utilization in Patients With Newly Diagnosed Diffuse Large B-Cell Lymphoma Within a Large Community Health System

Author: Michael J. Williams, Sol D. Atienza, Renee H. Aranda, Kayleigh B. Flint, Sherjeel Sana, Stephen C. Medlin, Zartash Gul, Federico A. Sanchez, and Michael A. Thompson
Subjects: cns, dlbcl, prophylaxis, intrathecal, chemotherapy, methotrexate, Medicine
Abstract: Purpose: The impact of central nervous system (CNS) prophylaxis in diffuse large B-cell lymphoma (DLBCL) is contentious. The CNS International Prognostic Index (IPI) calculator offers prognostic guidance in identifying those patients who may be at highest risk of disease progression or relapse to the CNS. However, it is unclear whether this tool has guided clinician decision-making in a real-world setting. Studies have suggested that CNS prophylaxis may not offer clinically significant benefit in terms of preventing CNS disease progression. Given this, we investigated the utilization of CNS prophylaxis within our own population and documentation of the CNS-IPI score. Methods: We retrospectively evaluated patients with newly diagnosed DLBCL between January 1, 2014, and December 31, 2017. Patients were assessed for receipt of CNS prophylaxis in the form of intrathecal (IT) chemotherapy and/or high-dose intravenous (IV) methotrexate. CNS-IPI scores were calculated for all patients who received CNS prophylaxis or those who experienced CNS disease. Long-term outcomes at five years from diagnosis included CNS progression/relapse and survival. Results: Of 234 patients who met criteria, 20 (8.6%) received either IV methotrexate or IT chemotherapy; most received IT methotrexate. No patients in the IT prophylaxis group developed CNS disease, while two of eight IV methotrexate patients experienced CNS disease involvement. The incidence of CNS progression was 3.7% in the no prophylaxis group and 10% in those who received prophylaxis. Conclusions: This study revealed low utilization of CNS prophylaxis and CNS-IPI documentation in a community hospital system. Given large differences between groups, claims of CNS prophylaxis efficacy are unable to be made. CNS relapse rates were consistent with existing literature and promote continued evaluation of the utility of current CNS prophylaxis approaches in DLBCL. New unambiguously effective therapeutic approaches are needed and may encourage a higher rate of standardized use.
Published: 2024
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29. Search for the B s 0 $$ {B}_s^0 $$ → μ + μ − γ decay

Author: The LHCb collaboration, R. Aaij, A. S. W. Abdelmotteleb, C. Abellan Beteta, F. Abudinén, T. Ackernley, A. A. Adefisoye, B. Adeva, M. Adinolfi, P. Adlarson, C. Agapopoulou, C. A. Aidala, Z. Ajaltouni, S. Akar, K. Akiba, P. Albicocco, J. Albrecht, F. Alessio, M. Alexander, Z. Aliouche, P. Alvarez Cartelle, R. Amalric, S. Amato, J. L. Amey, Y. Amhis, L. An, L. Anderlini, M. Andersson, A. Andreianov, P. Andreola, M. Andreotti, D. Andreou, A. Anelli, D. Ao, F. Archilli, M. Argenton, S. Arguedas Cuendis, A. Artamonov, M. Artuso, E. Aslanides, M. Atzeni, B. Audurier, D. Bacher, I. Bachiller Perea, S. Bachmann, M. Bachmayer, J. J. Back, P. Baladron Rodriguez, V. Balagura, W. Baldini, J. Baptista de Souza Leite, M. Barbetti, I. R. Barbosa, R. J. Barlow, S. Barsuk, W. Barter, M. Bartolini, J. Bartz, F. Baryshnikov, J. M. Basels, G. Bassi, B. Batsukh, A. Battig, A. Bay, A. Beck, M. Becker, F. Bedeschi, I. B. Bediaga, A. Beiter, S. Belin, V. Bellee, K. Belous, I. Belov, I. Belyaev, G. Benane, G. Bencivenni, E. Ben-Haim, A. Berezhnoy, R. Bernet, S. Bernet Andres, C. Bertella, A. Bertolin, C. Betancourt, F. Betti, J. Bex, Ia. Bezshyiko, J. Bhom, M. S. Bieker, N. V. Biesuz, P. Billoir, A. Biolchini, M. Birch, F. C. R. Bishop, A. Bitadze, A. Bizzeti, T. Blake, F. Blanc, J. E. Blank, S. Blusk, V. Bocharnikov, J. A. Boelhauve, O. Boente Garcia, T. Boettcher, A. Bohare, A. Boldyrev, C. S. Bolognani, R. Bolzonella, N. Bondar, F. Borgato, S. Borghi, M. Borsato, J. T. Borsuk, S. A. Bouchiba, T. J. V. Bowcock, A. Boyer, C. Bozzi, M. J. Bradley, A. Brea Rodriguez, N. Breer, J. Brodzicka, A. Brossa Gonzalo, J. Brown, D. Brundu, E. Buchanan, A. Buonaura, L. Buonincontri, A. T. Burke, C. Burr, A. Bursche, A. Butkevich, J. S. Butter, J. Buytaert, W. Byczynski, S. Cadeddu, H. Cai, R. Calabrese, L. Calefice, S. Cali, M. Calvi, M. Calvo Gomez, J. I. Cambon Bouzas, P. Campana, D. H. Campora Perez, A. F. Campoverde Quezada, S. Capelli, L. Capriotti, R. Caravaca-Mora, A. Carbone, L. Carcedo Salgado, R. Cardinale, A. Cardini, P. Carniti, L. Carus, A. Casais Vidal, R. Caspary, G. Casse, J. Castro Godinez, M. Cattaneo, G. Cavallero, V. Cavallini, S. Celani, J. Cerasoli, D. Cervenkov, S. Cesare, A. J. Chadwick, I. Chahrour, M. Charles, Ph. Charpentier, C. A. Chavez Barajas, M. Chefdeville, C. Chen, S. Chen, Z. Chen, A. Chernov, S. Chernyshenko, V. Chobanova, S. Cholak, M. Chrzaszcz, A. Chubykin, V. Chulikov, P. Ciambrone, X. Cid Vidal, G. Ciezarek, P. Cifra, P. E. L. Clarke, M. Clemencic, H. V. Cliff, J. Closier, C. Cocha Toapaxi, V. Coco, J. Cogan, E. Cogneras, L. Cojocariu, P. Collins, T. Colombo, A. Comerma-Montells, L. Congedo, A. Contu, N. Cooke, I. Corredoira, A. Correia, G. Corti, J. J. Cottee Meldrum, B. Couturier, D. C. Craik, M. Cruz Torres, E. Curras Rivera, R. Currie, C. L. Da Silva, S. Dadabaev, L. Dai, X. Dai, E. Dall’Occo, J. Dalseno, C. D’Ambrosio, J. Daniel, A. Danilina, P. d’Argent, A. Davidson, J. E. Davies, A. Davis, O. De Aguiar Francisco, C. De Angelis, F. De Benedetti, J. de Boer, K. De Bruyn, S. De Capua, M. De Cian, U. De Freitas Carneiro Da Graca, E. De Lucia, J. M. De Miranda, L. De Paula, M. De Serio, D. De Simone, P. De Simone, F. De Vellis, J. A. de Vries, F. Debernardis, D. Decamp, V. Dedu, L. Del Buono, B. Delaney, H.-P. Dembinski, J. Deng, V. Denysenko, O. Deschamps, F. Dettori, B. Dey, P. Di Nezza, I. Diachkov, S. Didenko, S. Ding, L. Dittmann, V. Dobishuk, A. D. Docheva, A. Dolmatov, C. Dong, A. M. Donohoe, F. Dordei, A. C. dos Reis, A. D. Dowling, A. G. Downes, W. Duan, P. Duda, M. W. Dudek, L. Dufour, V. Duk, P. Durante, M. M. Duras, J. M. Durham, O. D. Durmus, A. Dziurda, A. Dzyuba, S. Easo, E. Eckstein, U. Egede, A. Egorychev, V. Egorychev, S. Eisenhardt, E. Ejopu, S. Ek-In, L. Eklund, M. Elashri, J. Ellbracht, S. Ely, A. Ene, E. Epple, S. Escher, J. Eschle, S. Esen, T. Evans, F. Fabiano, L. N. Falcao, Y. Fan, B. Fang, L. Fantini, M. Faria, K. Farmer, D. Fazzini, L. Felkowski, M. Feng, M. Feo, M. Fernandez Gomez, A. D. Fernez, F. Ferrari, F. Ferreira Rodrigues, S. Ferreres Sole, M. Ferrillo, M. Ferro-Luzzi, S. Filippov, R. A. Fini, M. Fiorini, K. M. Fischer, D. S. Fitzgerald, C. Fitzpatrick, F. Fleuret, M. Fontana, L. F. Foreman, R. Forty, D. Foulds-Holt, M. Franco Sevilla, M. Frank, E. Franzoso, G. Frau, C. Frei, D. A. Friday, J. Fu, Q. Fuehring, Y. Fujii, T. Fulghesu, E. Gabriel, G. Galati, M. D. Galati, A. Gallas Torreira, D. Galli, S. Gambetta, M. Gandelman, P. Gandini, H. Gao, R. Gao, Y. Gao, M. Garau, L. M. Garcia Martin, P. Garcia Moreno, J. García Pardiñas, K. G. Garg, L. Garrido, C. Gaspar, R. E. Geertsema, L. L. Gerken, E. Gersabeck, M. Gersabeck, T. Gershon, Z. Ghorbanimoghaddam, L. Giambastiani, F. I. Giasemis, V. Gibson, H. K. Giemza, A. L. Gilman, M. Giovannetti, A. Gioventù, P. Gironella Gironell, C. Giugliano, M. A. Giza, E. L. Gkougkousis, F. C. Glaser, V. V. Gligorov, C. Göbel, E. Golobardes, D. Golubkov, A. Golutvin, A. Gomes, S. Gomez Fernandez, F. Goncalves Abrantes, M. Goncerz, G. Gong, J. A. Gooding, I. V. Gorelov, C. Gotti, J. P. Grabowski, L. A. Granado Cardoso, E. Graugés, E. Graverini, L. Grazette, G. Graziani, A. T. Grecu, L. M. Greeven, N. A. Grieser, L. Grillo, S. Gromov, C. Gu, M. Guarise, M. Guittiere, V. Guliaeva, P. A. Günther, A.-K. Guseinov, E. Gushchin, Y. Guz, T. Gys, K. Habermann, T. Hadavizadeh, C. Hadjivasiliou, G. Haefeli, C. Haen, J. Haimberger, M. Hajheidari, M. M. Halvorsen, P. M. Hamilton, J. Hammerich, Q. Han, X. Han, S. Hansmann-Menzemer, L. Hao, N. Harnew, T. Harrison, M. Hartmann, J. He, K. Heijhoff, F. Hemmer, C. Henderson, R. D. L. Henderson, A. M. Hennequin, K. Hennessy, L. Henry, J. Herd, P. Herrero Gascon, J. Heuel, A. Hicheur, G. Hijano Mendizabal, D. Hill, S. E. Hollitt, J. Horswill, R. Hou, Y. Hou, N. Howarth, J. Hu, W. Hu, X. Hu, W. Huang, W. Hulsbergen, R. J. Hunter, M. Hushchyn, D. Hutchcroft, D. Ilin, P. Ilten, A. Inglessi, A. Iniukhin, A. Ishteev, K. Ivshin, R. Jacobsson, H. Jage, S. J. Jaimes Elles, S. Jakobsen, E. Jans, B. K. Jashal, A. Jawahery, V. Jevtic, E. Jiang, X. Jiang, Y. Jiang, Y. J. Jiang, M. John, D. Johnson, C. R. Jones, T. P. Jones, S. Joshi, B. Jost, N. Jurik, I. Juszczak, D. Kaminaris, S. Kandybei, Y. Kang, M. Karacson, D. Karpenkov, A. Kauniskangas, J. W. Kautz, F. Keizer, M. Kenzie, T. Ketel, B. Khanji, A. Kharisova, S. Kholodenko, G. Khreich, T. Kirn, V. S. Kirsebom, O. Kitouni, S. Klaver, N. Kleijne, K. Klimaszewski, M. R. Kmiec, S. Koliiev, L. Kolk, A. Konoplyannikov, P. Kopciewicz, P. Koppenburg, M. Korolev, I. Kostiuk, O. Kot, S. Kotriakhova, A. Kozachuk, P. Kravchenko, L. Kravchuk, M. Kreps, S. Kretzschmar, P. Krokovny, W. Krupa, W. Krzemien, J. Kubat, S. Kubis, W. Kucewicz, M. Kucharczyk, V. Kudryavtsev, E. Kulikova, A. Kupsc, B. K. Kutsenko, D. Lacarrere, A. Lai, A. Lampis, D. Lancierini, C. Landesa Gomez, J. J. Lane, R. Lane, C. Langenbruch, J. Langer, O. Lantwin, T. Latham, F. Lazzari, C. Lazzeroni, R. Le Gac, R. Lefèvre, A. Leflat, S. Legotin, M. Lehuraux, E. Lemos Cid, O. Leroy, T. Lesiak, B. Leverington, A. Li, H. Li, K. Li, L. Li, P. Li, P.-R. Li, S. Li, T. Li, Y. Li, Z. Li, Z. Lian, X. Liang, S. Libralon, C. Lin, T. Lin, R. Lindner, V. Lisovskyi, R. Litvinov, F. L. Liu, G. Liu, K. Liu, Q. Liu, S. Liu, Y. Liu, Y. L. Liu, A. Lobo Salvia, A. Loi, J. Lomba Castro, T. Long, J. H. Lopes, A. Lopez Huertas, S. López Soliño, G. H. Lovell, C. Lucarelli, D. Lucchesi, M. Lucio Martinez, V. Lukashenko, Y. Luo, A. Lupato, E. Luppi, K. Lynch, X.-R. Lyu, G. M. Ma, R. Ma, S. Maccolini, F. Machefert, F. Maciuc, B. M. Mack, I. Mackay, L. M. Mackey, L. R. Madhan Mohan, M. M. Madurai, A. Maevskiy, D. Magdalinski, D. Maisuzenko, M. W. Majewski, J. J. Malczewski, S. Malde, B. Malecki, L. Malentacca, A. Malinin, T. Maltsev, G. Manca, G. Mancinelli, C. Mancuso, R. Manera Escalero, D. Manuzzi, D. Marangotto, J. F. Marchand, R. Marchevski, U. Marconi, S. Mariani, C. Marin Benito, J. Marks, A. M. Marshall, P. J. Marshall, G. Martelli, G. Martellotti, L. Martinazzoli, M. Martinelli, D. Martinez Santos, F. Martinez Vidal, A. Massafferri, M. Materok, R. Matev, A. Mathad, V. Matiunin, C. Matteuzzi, K. R. Mattioli, A. Mauri, E. Maurice, J. Mauricio, P. Mayencourt, M. Mazurek, M. McCann, L. Mcconnell, T. H. McGrath, N. T. McHugh, A. McNab, R. McNulty, B. Meadows, G. Meier, D. Melnychuk, M. Merk, A. Merli, L. Meyer Garcia, D. Miao, H. Miao, M. Mikhasenko, D. A. Milanes, A. Minotti, E. Minucci, T. Miralles, B. Mitreska, D. S. Mitzel, A. Modak, A. Mödden, R. A. Mohammed, R. D. Moise, S. Mokhnenko, T. Mombächer, M. Monk, S. Monteil, A. Morcillo Gomez, G. Morello, M. J. Morello, M. P. Morgenthaler, A. B. Morris, A. G. Morris, R. Mountain, H. Mu, Z. M. Mu, E. Muhammad, F. Muheim, M. Mulder, K. Müller, F. Muñoz-Rojas, R. Murta, P. Naik, T. Nakada, R. Nandakumar, T. Nanut, I. Nasteva, M. Needham, N. Neri, S. Neubert, N. Neufeld, P. Neustroev, J. Nicolini, D. Nicotra, E. M. Niel, N. Nikitin, P. Nogga, N. S. Nolte, C. Normand, J. Novoa Fernandez, G. Nowak, C. Nunez, H. N. Nur, A. Oblakowska-Mucha, V. Obraztsov, T. Oeser, S. Okamura, A. Okhotnikov, R. Oldeman, F. Oliva, M. Olocco, C. J. G. Onderwater, R. H. O’Neil, J. M. Otalora Goicochea, P. Owen, A. Oyanguren, O. Ozcelik, K. O. Padeken, B. Pagare, P. R. Pais, T. Pajero, A. Palano, M. Palutan, G. Panshin, L. Paolucci, A. Papanestis, M. Pappagallo, L. L. Pappalardo, C. Pappenheimer, C. Parkes, B. Passalacqua, G. Passaleva, D. Passaro, A. Pastore, M. Patel, J. Patoc, C. Patrignani, C. J. Pawley, A. Pellegrino, M. Pepe Altarelli, S. Perazzini, D. Pereima, A. Pereiro Castro, P. Perret, A. Perro, K. Petridis, A. Petrolini, S. Petrucci, J. P. Pfaller, H. Pham, L. Pica, M. Piccini, B. Pietrzyk, G. Pietrzyk, D. Pinci, F. Pisani, M. Pizzichemi, V. Placinta, M. Plo Casasus, F. Polci, M. Poli Lener, A. Poluektov, N. Polukhina, I. Polyakov, E. Polycarpo, S. Ponce, D. Popov, S. Poslavskii, K. Prasanth, C. Prouve, V. Pugatch, G. Punzi, W. Qian, N. Qin, S. Qu, R. Quagliani, R. I. Rabadan Trejo, J. H. Rademacker, M. Rama, M. Ramírez García, M. Ramos Pernas, M. S. Rangel, F. Ratnikov, G. Raven, M. Rebollo De Miguel, M. Reboud, F. Redi, J. Reich, F. Reiss, Z. Ren, P. K. Resmi, R. Ribatti, G. R. Ricart, D. Riccardi, S. Ricciardi, K. Richardson, M. Richardson-Slipper, K. Rinnert, P. Robbe, G. Robertson, E. Rodrigues, E. Rodriguez Fernandez, J. A. Rodriguez Lopez, E. Rodriguez Rodriguez, A. Rogovskiy, D. L. Rolf, P. Roloff, V. Romanovskiy, M. Romero Lamas, A. Romero Vidal, G. Romolini, F. Ronchetti, M. Rotondo, S. R. Roy, M. S. Rudolph, T. Ruf, M. Ruiz Diaz, R. A. Ruiz Fernandez, J. Ruiz Vidal, A. Ryzhikov, J. Ryzka, J. J. Saavedra-Arias, J. J. Saborido Silva, R. Sadek, N. Sagidova, D. Sahoo, N. Sahoo, B. Saitta, M. Salomoni, C. Sanchez Gras, I. Sanderswood, R. Santacesaria, C. Santamarina Rios, M. Santimaria, L. Santoro, E. Santovetti, A. Saputi, D. Saranin, G. Sarpis, M. Sarpis, A. Sarti, C. Satriano, A. Satta, M. Saur, D. Savrina, H. Sazak, L. G. Scantlebury Smead, A. Scarabotto, S. Schael, S. Scherl, A. M. Schertz, M. Schiller, H. Schindler, M. Schmelling, B. Schmidt, S. Schmitt, H. Schmitz, O. Schneider, A. Schopper, N. Schulte, S. Schulte, M. H. Schune, R. Schwemmer, G. Schwering, B. Sciascia, A. Sciuccati, S. Sellam, A. Semennikov, T. Senger, M. Senghi Soares, A. Sergi, N. Serra, L. Sestini, A. Seuthe, Y. Shang, D. M. Shangase, M. Shapkin, R. S. Sharma, I. Shchemerov, L. Shchutska, T. Shears, L. Shekhtman, Z. Shen, S. Sheng, V. Shevchenko, B. Shi, E. B. Shields, Y. Shimizu, E. Shmanin, R. Shorkin, J. D. Shupperd, R. Silva Coutinho, G. Simi, S. Simone, N. Skidmore, T. Skwarnicki, M. W. Slater, J. C. Smallwood, E. Smith, K. Smith, M. Smith, A. Snoch, L. Soares Lavra, M. D. Sokoloff, F. J. P. Soler, A. Solomin, A. Solovev, I. Solovyev, R. Song, Y. Song, Y. S. Song, F. L. Souza De Almeida, B. Souza De Paula, E. Spadaro Norella, E. Spedicato, J. G. Speer, E. Spiridenkov, P. Spradlin, V. Sriskaran, F. Stagni, M. Stahl, S. Stahl, S. Stanislaus, E. N. Stein, O. Steinkamp, O. Stenyakin, H. Stevens, D. Strekalina, Y. Su, F. Suljik, J. Sun, L. Sun, Y. Sun, W. Sutcliffe, P. N. Swallow, F. Swystun, A. Szabelski, T. Szumlak, Y. Tan, S. Taneja, M. D. Tat, A. Terentev, F. Terzuoli, F. Teubert, E. Thomas, D. J. D. Thompson, H. Tilquin, V. Tisserand, S. T’Jampens, M. Tobin, L. Tomassetti, G. Tonani, X. Tong, D. Torres Machado, L. Toscano, D. Y. Tou, C. Trippl, G. Tuci, N. Tuning, L. H. Uecker, A. Ukleja, D. J. Unverzagt, E. Ursov, A. Usachov, A. Ustyuzhanin, U. Uwer, V. Vagnoni, A. Valassi, G. Valenti, N. Valls Canudas, H. Van Hecke, E. van Herwijnen, C. B. Van Hulse, R. Van Laak, M. van Veghel, R. Vazquez Gomez, P. Vazquez Regueiro, C. Vázquez Sierra, S. Vecchi, J. J. Velthuis, M. Veltri, A. Venkateswaran, M. Vesterinen, M. Vieites Diaz, X. Vilasis-Cardona, E. Vilella Figueras, A. Villa, P. Vincent, F. C. Volle, D. vom Bruch, V. Vorobyev, N. Voropaev, K. Vos, G. Vouters, C. Vrahas, J. Wagner, J. Walsh, E. J. Walton, G. Wan, C. Wang, G. Wang, J. Wang, M. Wang, N. W. Wang, R. Wang, X. Wang, X. W. Wang, Y. Wang, Z. Wang, J. A. Ward, M. Waterlaat, N. K. Watson, D. Websdale, Y. Wei, B. D. C. Westhenry, D. J. White, M. Whitehead, A. R. Wiederhold, D. Wiedner, G. Wilkinson, M. K. Wilkinson, M. Williams, M. R. J. Williams, R. Williams, F. F. Wilson, W. Wislicki, M. Witek, L. Witola, C. P. Wong, G. Wormser, S. A. Wotton, H. Wu, J. Wu, X. Wu, Y. Wu, K. Wyllie, S. Xian, Z. Xiang, Y. Xie, A. Xu, J. Xu, L. Xu, M. Xu, Z. Xu, D. Yang, S. Yang, X. Yang, Y. Yang, Z. Yang, V. Yeroshenko, H. Yeung, H. Yin, C. Y. Yu, J. Yu, X. Yuan, E. Zaffaroni, M. Zavertyaev, M. Zdybal, M. Zeng, C. Zhang, D. Zhang, J. Zhang, L. Zhang, S. Zhang, Y. Zhang, Y. Z. Zhang, Y. Zhao, A. Zharkova, A. Zhelezov, X. Z. Zheng, Y. Zheng, T. Zhou, X. Zhou, Y. Zhou, V. Zhovkovska, L. Z. Zhu, X. Zhu, V. Zhukov, J. Zhuo, Q. Zou, D. Zuliani, and G. Zunica
Subjects: B Physics, Flavour Physics, Hadron-Hadron Scattering, Rare Decay, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract: Abstract A search for the fully reconstructed B s 0 $$ {B}_s^0 $$ → μ + μ − γ decay is performed at the LHCb experiment using proton-proton collisions at s $$ \sqrt{s} $$ = 13 TeV corresponding to an integrated luminosity of 5.4 fb −1. No significant signal is found and upper limits on the branching fraction in intervals of the dimuon mass are set B B s 0 → μ + μ − γ < 4.2 × 10 − 8 , m μ + μ − ∈ 2 m μ 1.70 GeV / c 2 , B B s 0 → μ + μ − γ < 7.7 × 10 − 8 , m μ + μ − ∈ 1.70, 2.88 GeV / c 2 , B B s 0 → μ + μ − γ < 4.2 × 10 − 8 , m μ + μ − ∈ 3.92 m B s 0 GeV / c 2 , $$ {\displaystyle \begin{array}{cc}\mathcal{B}\left({B}_s^0\to {\mu}^{+}{\mu}^{-}\gamma \right)
Published: 2024
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30. The mycobacterial glycoside hydrolase LamH enables capsular arabinomannan release and stimulates growth

Author: Aaron Franklin, Vivian C. Salgueiro, Abigail J. Layton, Rudi Sullivan, Todd Mize, Lucía Vázquez-Iniesta, Samuel T. Benedict, Sudagar S. Gurcha, Itxaso Anso, Gurdyal S. Besra, Manuel Banzhaf, Andrew L. Lovering, Spencer J. Williams, Marcelo E. Guerin, Nichollas E. Scott, Rafael Prados-Rosales, Elisabeth C. Lowe, and Patrick J. Moynihan
Subjects: Science
Abstract: Abstract Mycobacterial glycolipids are important cell envelope structures that drive host-pathogen interactions. Arguably, the most important are lipoarabinomannan (LAM) and its precursor, lipomannan (LM), which are trafficked from the bacterium to the host via unknown mechanisms. Arabinomannan is thought to be a capsular derivative of these molecules, lacking a lipid anchor. However, the mechanism by which this material is generated has yet to be elucidated. Here, we describe the identification of a glycoside hydrolase family 76 enzyme that we term LamH (Rv0365c in Mycobacterium tuberculosis) which specifically cleaves α−1,6-mannoside linkages within LM and LAM, driving its export to the capsule releasing its phosphatidyl-myo-inositol mannoside lipid anchor. Unexpectedly, we found that the catalytic activity of this enzyme is important for efficient exit from stationary phase cultures, potentially implicating arabinomannan as a signal for growth phase transition. Finally, we demonstrate that LamH is important for M. tuberculosis survival in macrophages.
Published: 2024
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31. Ocean warming and acidification adjust inter- and intra-specific variability in the functional trait expression of polar invertebrates

Author: Thomas J. Williams, Adam J. Reed, Lloyd S. Peck, Jasmin A. Godbold, and Martin Solan
Subjects: Bioturbation, Benthic, Plasticity, Climate futures, Polar front, Arctic, Medicine, Science
Abstract: Abstract Climate change is known to affect the distribution and composition of species, but concomitant alterations to functionally important aspects of behaviour and species-environment relations are poorly constrained. Here, we examine the ecosystem ramifications of changes in sediment-dwelling invertebrate bioturbation behaviour—a key process mediating nutrient cycling—associated with near-future environmental conditions (+ 1.5 °C, 550 ppm [pCO2]) for species from polar regions experiencing rapid rates of climate change. We find that responses to warming and acidification vary between species and lead to a reduction in intra-specific variability in behavioural trait expression that adjusts the magnitude and direction of nutrient concentrations. Our analyses also indicate that species behaviour is not predetermined, but can be dependent on local variations in environmental history that set population capacities for phenotypic plasticity. We provide evidence that certain, but subtle, aspects of inter- and intra-specific variation in behavioural trait expression, rather than the presence or proportional representation of species per se, is an important and under-appreciated determinant of benthic biogeochemical responses to climate change. Such changes in species behaviour may act as an early warning for impending ecological transitions associated with progressive climate forcing.
Published: 2024
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32. Search for central exclusive production of top quark pairs in proton-proton collisions at s $$ \sqrt{s} $$ = 13 TeV with tagged protons

Author: The CMS collaboration, A. Tumasyan, W. Adam, J. W. Andrejkovic, T. Bergauer, S. Chatterjee, K. Damanakis, M. Dragicevic, A. Escalante Del Valle, P. S. Hussain, M. Jeitler, N. Krammer, L. Lechner, D. Liko, I. Mikulec, P. Paulitsch, F. M. Pitters, J. Schieck, R. Schöfbeck, D. Schwarz, S. Templ, W. Waltenberger, C.-E. Wulz, M. R. Darwish, T. Janssen, T. Kello, H. Rejeb Sfar, P. Van Mechelen, E. S. Bols, J. D’Hondt, A. De Moor, M. Delcourt, H. El Faham, S. Lowette, S. Moortgat, A. Morton, D. Müller, A. R. Sahasransu, S. Tavernier, W. Van Doninck, D. Vannerom, B. Clerbaux, G. De Lentdecker, L. Favart, D. Hohov, J. Jaramillo, K. Lee, M. Mahdavikhorrami, I. Makarenko, A. Malara, S. Paredes, L. Pétré, N. Postiau, E. Starling, L. Thomas, M. Vanden Bemden, C. Vander Velde, P. Vanlaer, D. Dobur, J. Knolle, L. Lambrecht, G. Mestdach, M. Niedziela, C. Rendón, C. Roskas, A. Samalan, K. Skovpen, M. Tytgat, N. Van Den Bossche, B. Vermassen, L. Wezenbeek, A. Benecke, G. Bruno, F. Bury, C. Caputo, P. David, C. Delaere, I. S. Donertas, A. Giammanco, K. Jaffel, Sa. Jain, V. Lemaitre, K. Mondal, J. Prisciandaro, A. Taliercio, T. T. Tran, P. Vischia, S. Wertz, G. A. Alves, E. Coelho, C. Hensel, A. Moraes, P. Rebello Teles, W. L. Aldá Júnior, M. Alves Gallo Pereira, M. Barroso Ferreira Filho, H. Brandao Malbouisson, W. Carvalho, J. Chinellato, E. M. Da Costa, G. G. Da Silveira, D. De Jesus Damiao, V. Dos Santos Sousa, S. Fonseca De Souza, J. Martins, C. Mora Herrera, K. Mota Amarilo, L. Mundim, H. Nogima, A. Santoro, S. M. Silva Do Amaral, A. Sznajder, M. Thiel, F. Torres Da Silva De Araujo, A. Vilela Pereira, C. A. Bernardes, L. Calligaris, T. R. Fernandez Perez Tomei, E. M. Gregores, P. G. Mercadante, S. F. Novaes, Sandra S. Padula, A. Aleksandrov, R. Hadjiiska, P. Iaydjiev, M. Misheva, M. Rodozov, M. Shopova, G. Sultanov, A. Dimitrov, T. Ivanov, L. Litov, B. Pavlov, P. Petkov, A. Petrov, E. Shumka, T. Cheng, T. Javaid, M. Mittal, L. Yuan, M. Ahmad, G. Bauer, Z. Hu, S. Lezki, K. Yi, G. M. Chen, H. S. Chen, M. Chen, F. Iemmi, C. H. Jiang, A. Kapoor, H. Liao, Z.-A. Liu, V. Milosevic, F. Monti, R. Sharma, J. Tao, J. Thomas-Wilsker, J. Wang, H. Zhang, J. Zhao, A. Agapitos, Y. An, Y. Ban, C. Chen, A. Levin, C. Li, Q. Li, X. Lyu, Y. Mao, S. J. Qian, X. Sun, D. Wang, J. Xiao, H. Yang, J. Li, M. Lu, Z. You, X. Gao, D. Leggat, H. Okawa, Y. Zhang, Z. Lin, C. Lu, M. Xiao, C. Avila, D. A. Barbosa Trujillo, A. Cabrera, C. Florez, J. Fraga, J. Mejia Guisao, F. Ramirez, M. Rodriguez, J. D. Ruiz Alvarez, D. Giljanovic, N. Godinovic, D. Lelas, I. Puljak, Z. Antunovic, M. Kovac, T. Sculac, V. Brigljevic, B. K. Chitroda, D. Ferencek, D. Majumder, M. Roguljic, A. Starodumov, T. Susa, A. Attikis, K. Christoforou, G. Kole, M. Kolosova, S. Konstantinou, J. Mousa, C. Nicolaou, F. Ptochos, P. A. Razis, H. Rykaczewski, H. Saka, M. Finger, A. Kveton, E. Ayala, E. Carrera Jarrin, S. Elgammal, A. Ellithi Kamel, M. A. Mahmoud, Y. Mohammed, S. Bhowmik, R. K. Dewanjee, K. 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Carnahan, M. Decaro, S. Dildick, K. M. Ecklund, P. J. Fernández Manteca, S. Freed, P. Gardner, F. J. M. Geurts, W. Li, B. P. Padley, R. Redjimi, J. Rotter, W. Shi, E. Yigitbasi, L. Zhang, X. Zuo, A. Bodek, P. de Barbaro, R. Demina, J. L. Dulemba, C. Fallon, T. Ferbel, M. Galanti, A. Garcia-Bellido, O. Hindrichs, A. Khukhunaishvili, E. Ranken, R. Taus, G. P. Van Onsem, K. Goulianos, B. Chiarito, J. P. Chou, Y. Gershtein, E. Halkiadakis, A. Hart, M. Heindl, D. Jaroslawski, O. Karacheban, I. Laflotte, A. Lath, R. Montalvo, K. Nash, M. Osherson, S. Salur, S. Schnetzer, S. Somalwar, R. Stone, S. A. Thayil, S. Thomas, H. Wang, H. Acharya, A. G. Delannoy, S. Fiorendi, T. Holmes, E. Nibigira, S. Spanier, O. Bouhali, M. Dalchenko, A. Delgado, R. Eusebi, J. Gilmore, T. Huang, T. Kamon, S. Luo, S. Malhotra, R. Mueller, D. Overton, D. Rathjens, A. Safonov, N. Akchurin, J. Damgov, V. Hegde, K. Lamichhane, T. Mengke, S. Muthumuni, T. Peltola, I. Volobouev, A. Whitbeck, E. Appelt, S. Greene, A. Gurrola, W. Johns, A. Melo, F. Romeo, P. Sheldon, S. Tuo, J. Velkovska, J. Viinikainen, B. Cardwell, B. Cox, G. Cummings, J. Hakala, R. Hirosky, M. Joyce, A. Ledovskoy, A. Li, C. Neu, C. E. Perez Lara, B. Tannenwald, P. E. Karchin, N. Poudyal, K. Black, T. Bose, S. Dasu, I. De Bruyn, P. Everaerts, C. Galloni, H. He, M. Herndon, A. Herve, C. K. Koraka, A. Lanaro, A. Loeliger, R. Loveless, J. Madhusudanan Sreekala, A. Mallampalli, A. Mohammadi, G. Parida, D. Pinna, A. Savin, V. Shang, W. H. Smith, D. Teague, H. F. Tsoi, W. Vetens, S. Afanasiev, V. Andreev, Yu. Andreev, T. Aushev, M. Azarkin, A. Babaev, V. Blinov, E. Boos, D. Budkouski, V. Bunichev, O. Bychkova, M. Chadeeva, V. Chekhovsky, A. Dermenev, T. Dimova, I. Dremin, M. Dubinin, L. Dudko, V. Epshteyn, G. Gavrilov, V. Gavrilov, S. Gninenko, V. Golovtcov, N. Golubev, I. Golutvin, I. Gorbunov, A. Gribushin, Y. Ivanov, V. Kachanov, L. Kardapoltsev, V. Karjavine, A. Karneyeu, V. Kim, M. Kirakosyan, D. Kirpichnikov, M. Kirsanov, V. Klyukhin, D. Konstantinov, V. Korenkov, A. Kozyrev, N. Krasnikov, E. Kuznetsova, A. Lanev, P. Levchenko, A. Litomin, O. Lukina, N. Lychkovskaya, V. Makarenko, A. Malakhov, V. Matveev, V. Murzin, A. Nikitenko, S. Obraztsov, V. Okhotnikov, I. Ovtin, V. Palichik, P. Parygin, V. Perelygin, M. Perfilov, G. Pivovarov, V. Popov, E. Popova, O. Radchenko, V. Rusinov, M. Savina, V. Savrin, D. Selivanova, V. Shalaev, S. Shmatov, S. Shulha, Y. Skovpen, S. Slabospitskii, V. Smirnov, D. Sosnov, A. Stepennov, V. Sulimov, A. Terkulov, O. Teryaev, I. Tlisova, M. Toms, A. Toropin, L. Uvarov, A. Uzunian, E. Vlasov, P. Volkov, A. Vorobyev, N. Voytishin, B. S. Yuldashev, A. Zarubin, I. Zhizhin, A. Zhokin, The TOTEM collaboration, G. Antchev, P. Aspell, I. Atanassov, V. Avati, J. Baechler, C. Baldenegro Barrera, V. Berardi, M. Berretti, V. Borshch, E. Bossini, U. Bottigli, M. Bozzo, H. Burkhardt, F. S. Cafagna, M. G. Catanesi, M. Deile, F. De Leonardis, M. Doubek, D. Druzhkin, K. Eggert, V. Eremin, A. Fiergolski, F. Garcia, V. Georgiev, S. Giani, L. Grzanka, J. Hammerbauer, T. Isidori, V. Ivanchenko, M. Janda, A. Karev, J. Kašpar, B. Kaynak, J. Kopal, V. Kundrát, S. Lami, R. Linhart, C. Lindsey, M. V. Lokajíček, L. Losurdo, F. Lucas Rodríguez, M. Macrí, M. Malawski, N. Minafra, S. Minutoli, K. Misan, T. Naaranoja, F. Nemes, H. Niewiadomski, E. Oliveri, F. Oljemark, M. Oriunno, K. Österberg, S. Ozkorucuklu, P. Palazzi, V. Passaro, Z. Peroutka, O. Potok, J. Procházka, M. Quinto, E. Radermacher, E. Radicioni, F. Ravotti, C. Royon, G. Ruggiero, H. Saarikko, V. D. Samoylenko, A. Scribano, J. Široký, J. Smajek, W. Snoeys, R. Stefanovitch, C. Taylor, E. Tcherniaev, N. Turini, O. Urban, V. Vacek, O. Vavroch, J. Welti, J. Williams, and J. Zich
Subjects: Hadron-Hadron Scattering, Top Physics, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract: Abstract A search for the central exclusive production of top quark-antiquark pairs ( t t ¯ $$ \textrm{t}\overline{\textrm{t}} $$ ) is performed for the first time using proton-tagged events in proton-proton collisions at the LHC at a centre-of-mass energy of 13 TeV. The data correspond to an integrated luminosity of 29.4 fb −1. The t t ¯ $$ \textrm{t}\overline{\textrm{t}} $$ decay products are reconstructed using the central CMS detector, while forward protons are measured in the CMS-TOTEM precision proton spectrometer. An observed (expected) upper bound on the production cross section of 0.59 (1.14) pb is set at 95% confidence level, for collisions of protons with fractional momentum losses between 2 and 20%.
Published: 2024
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33. Amplitude analysis of the Λ b 0 → pK − γ $$ {\Lambda}_{\textrm{b}}^0\to {\textrm{pK}}^{-}\upgamma $$ decay

Author: The LHCb collaboration, R. Aaij, A. S. W. Abdelmotteleb, C. Abellan Beteta, F. Abudinén, T. Ackernley, B. Adeva, M. Adinolfi, P. Adlarson, C. Agapopoulou, C. A. Aidala, Z. Ajaltouni, S. Akar, K. Akiba, P. Albicocco, J. Albrecht, F. Alessio, M. Alexander, A. Alfonso Albero, Z. Aliouche, P. Alvarez Cartelle, R. Amalric, S. Amato, J. L. Amey, Y. Amhis, L. An, L. Anderlini, M. Andersson, A. Andreianov, P. Andreola, M. Andreotti, D. Andreou, A. Anelli, D. Ao, F. Archilli, M. Argenton, S. Arguedas Cuendis, A. Artamonov, M. Artuso, E. Aslanides, M. Atzeni, B. Audurier, D. Bacher, I. Bachiller Perea, S. Bachmann, M. Bachmayer, J. J. Back, P. Baladron Rodriguez, V. Balagura, W. Baldini, J. Baptista de Souza Leite, M. Barbetti, I. R. Barbosa, R. J. Barlow, S. Barsuk, W. Barter, M. Bartolini, J. Bartz, F. Baryshnikov, J. M. Basels, G. Bassi, B. Batsukh, A. Battig, A. Bay, A. Beck, M. Becker, F. Bedeschi, I. B. Bediaga, A. Beiter, S. Belin, V. Bellee, K. Belous, I. Belov, I. Belyaev, G. Benane, G. Bencivenni, E. Ben-Haim, A. Berezhnoy, R. Bernet, S. Bernet Andres, H. C. Bernstein, C. Bertella, A. Bertolin, C. Betancourt, F. Betti, J. Bex, Ia. Bezshyiko, J. Bhom, M. S. Bieker, N. V. Biesuz, P. Billoir, A. Biolchini, M. Birch, F. C. R. Bishop, A. Bitadze, A. Bizzeti, M. P. Blago, T. Blake, F. Blanc, J. E. Blank, S. Blusk, D. Bobulska, V. Bocharnikov, J. A. Boelhauve, O. Boente Garcia, T. Boettcher, A. Bohare, A. Boldyrev, C. S. Bolognani, R. Bolzonella, N. Bondar, F. Borgato, S. Borghi, M. Borsato, J. T. Borsuk, S. A. Bouchiba, T. J. V. Bowcock, A. Boyer, C. Bozzi, M. J. Bradley, S. Braun, A. Brea Rodriguez, N. Breer, J. Brodzicka, A. Brossa Gonzalo, J. Brown, D. Brundu, A. Buonaura, L. Buonincontri, A. T. Burke, C. Burr, A. Bursche, A. Butkevich, J. S. Butter, J. Buytaert, W. Byczynski, S. Cadeddu, H. Cai, R. Calabrese, L. Calefice, S. Cali, M. Calvi, M. Calvo Gomez, J. Cambon Bouzas, P. Campana, D. H. Campora Perez, A. F. Campoverde Quezada, S. Capelli, L. Capriotti, R. Caravaca-Mora, A. Carbone, L. Carcedo Salgado, R. Cardinale, A. Cardini, P. Carniti, L. Carus, A. Casais Vidal, R. Caspary, G. Casse, J. Castro Godinez, M. Cattaneo, G. Cavallero, V. Cavallini, S. Celani, J. Cerasoli, D. Cervenkov, S. Cesare, A. J. Chadwick, I. Chahrour, M. Charles, Ph. Charpentier, C. A. Chavez Barajas, M. Chefdeville, C. Chen, S. Chen, Z. Chen, A. Chernov, S. Chernyshenko, V. Chobanova, S. Cholak, M. Chrzaszcz, A. Chubykin, V. Chulikov, P. Ciambrone, M. F. Cicala, X. Cid Vidal, G. Ciezarek, P. Cifra, P. E. L. Clarke, M. Clemencic, H. V. Cliff, J. Closier, J. L. Cobbledick, C. Cocha Toapaxi, V. Coco, J. Cogan, E. Cogneras, L. Cojocariu, P. Collins, T. Colombo, A. Comerma-Montells, L. Congedo, A. Contu, N. Cooke, I. Corredoira, A. Correia, G. Corti, J. J. Cottee Meldrum, B. Couturier, D. C. Craik, M. Cruz Torres, E. Curras Rivera, R. Currie, C. L. Da Silva, S. Dadabaev, L. Dai, X. Dai, E. Dall’Occo, J. Dalseno, C. D’Ambrosio, J. Daniel, A. Danilina, P. d’Argent, A. Davidson, J. E. Davies, A. Davis, O. De Aguiar Francisco, C. De Angelis, J. de Boer, K. De Bruyn, S. De Capua, M. De Cian, U. De Freitas Carneiro Da Graca, E. De Lucia, J. M. De Miranda, L. De Paula, M. De Serio, D. De Simone, P. De Simone, F. De Vellis, J. A. de Vries, F. Debernardis, D. Decamp, V. Dedu, L. Del Buono, B. Delaney, H.-P. Dembinski, J. Deng, V. Denysenko, O. Deschamps, F. Dettori, B. Dey, P. Di Nezza, I. Diachkov, S. Didenko, S. Ding, V. Dobishuk, A. D. Docheva, A. Dolmatov, C. Dong, A. M. Donohoe, F. Dordei, A. C. dos Reis, L. Douglas, A. G. Downes, W. Duan, P. Duda, M. W. Dudek, L. Dufour, V. Duk, P. Durante, M. M. Duras, J. M. Durham, A. Dziurda, A. Dzyuba, S. Easo, E. Eckstein, U. Egede, A. Egorychev, V. Egorychev, C. Eirea Orro, S. Eisenhardt, E. Ejopu, S. Ek-In, L. Eklund, M. Elashri, J. Ellbracht, S. Ely, A. Ene, E. Epple, S. Escher, J. Eschle, S. Esen, T. Evans, F. Fabiano, L. N. Falcao, Y. Fan, B. Fang, L. Fantini, M. Faria, K. Farmer, D. Fazzini, L. Felkowski, M. Feng, M. Feo, M. Fernandez Gomez, A. D. Fernez, F. Ferrari, F. Ferreira Rodrigues, S. Ferreres Sole, M. Ferrillo, M. Ferro-Luzzi, S. Filippov, R. A. Fini, M. Fiorini, M. Firlej, K. M. Fischer, D. S. Fitzgerald, C. Fitzpatrick, T. Fiutowski, F. Fleuret, M. Fontana, F. Fontanelli, L. F. Foreman, R. Forty, D. Foulds-Holt, M. Franco Sevilla, M. Frank, E. Franzoso, G. Frau, C. Frei, D. A. Friday, L. Frontini, J. Fu, Q. Fuehring, Y. Fujii, T. Fulghesu, E. Gabriel, G. Galati, M. D. Galati, A. Gallas Torreira, D. Galli, S. Gambetta, M. Gandelman, P. Gandini, H. Gao, R. Gao, Y. Gao, M. Garau, L. M. Garcia Martin, P. Garcia Moreno, J. García Pardiñas, B. Garcia Plana, K. G. Garg, L. Garrido, C. Gaspar, R. E. Geertsema, L. L. Gerken, E. Gersabeck, M. Gersabeck, T. Gershon, Z. Ghorbanimoghaddam, L. Giambastiani, F. I. Giasemis, V. Gibson, H. K. Giemza, A. L. Gilman, M. Giovannetti, A. Gioventù, P. Gironella Gironell, C. Giugliano, M. A. Giza, E. L. Gkougkousis, F. C. Glaser, V. V. Gligorov, C. Göbel, E. Golobardes, D. Golubkov, A. Golutvin, A. Gomes, S. Gomez Fernandez, F. Goncalves Abrantes, M. Goncerz, G. Gong, J. A. Gooding, I. V. Gorelov, C. Gotti, J. P. Grabowski, L. A. Granado Cardoso, E. Graugés, E. Graverini, L. Grazette, G. Graziani, A. T. Grecu, L. M. Greeven, N. A. Grieser, L. Grillo, S. Gromov, C. Gu, M. Guarise, M. Guittiere, V. Guliaeva, P. A. Günther, A.-K. Guseinov, E. Gushchin, Y. Guz, T. Gys, T. Hadavizadeh, C. Hadjivasiliou, G. Haefeli, C. Haen, J. Haimberger, M. Hajheidari, T. Halewood-leagas, M. M. Halvorsen, P. M. Hamilton, J. Hammerich, Q. Han, X. Han, S. Hansmann-Menzemer, L. Hao, N. Harnew, T. Harrison, M. Hartmann, C. Hasse, J. He, K. Heijhoff, F. Hemmer, C. Henderson, R. D. L. Henderson, A. M. Hennequin, K. Hennessy, L. Henry, J. Herd, P. Herrero Gascon, J. Heuel, A. Hicheur, G. Hijano Mendizabal, D. Hill, S. E. Hollitt, J. Horswill, R. Hou, Y. Hou, N. Howarth, J. Hu, W. Hu, X. Hu, W. Huang, W. Hulsbergen, R. J. Hunter, M. Hushchyn, D. Hutchcroft, M. Idzik, D. Ilin, P. Ilten, A. Inglessi, A. Iniukhin, A. Ishteev, K. Ivshin, R. Jacobsson, H. Jage, S. J. Jaimes Elles, S. Jakobsen, E. Jans, B. K. Jashal, A. Jawahery, V. Jevtic, E. Jiang, X. Jiang, Y. Jiang, Y. J. Jiang, M. John, D. Johnson, C. R. Jones, T. P. Jones, S. Joshi, B. Jost, N. Jurik, I. Juszczak, D. Kaminaris, S. Kandybei, Y. Kang, M. Karacson, D. Karpenkov, M. Karpov, A. M. Kauniskangas, J. W. Kautz, F. Keizer, D. M. Keller, M. Kenzie, T. Ketel, B. Khanji, A. Kharisova, S. Kholodenko, G. Khreich, T. Kirn, V. S. Kirsebom, O. Kitouni, S. Klaver, N. Kleijne, K. Klimaszewski, M. R. Kmiec, S. Koliiev, L. Kolk, A. Konoplyannikov, P. Kopciewicz, P. Koppenburg, M. Korolev, I. Kostiuk, O. Kot, S. Kotriakhova, A. Kozachuk, P. Kravchenko, L. Kravchuk, M. Kreps, S. Kretzschmar, P. Krokovny, W. Krupa, W. Krzemien, J. Kubat, S. Kubis, W. Kucewicz, M. Kucharczyk, V. Kudryavtsev, E. Kulikova, A. Kupsc, B. K. Kutsenko, D. Lacarrere, A. Lai, A. Lampis, D. Lancierini, C. Landesa Gomez, J. J. Lane, R. Lane, C. Langenbruch, J. Langer, O. Lantwin, T. Latham, F. Lazzari, C. Lazzeroni, R. Le Gac, S. H. Lee, R. Lefèvre, A. Leflat, S. Legotin, M. Lehuraux, O. Leroy, T. Lesiak, B. Leverington, A. Li, H. Li, K. Li, L. Li, P. Li, P.-R. Li, S. Li, T. Li, Y. Li, Z. Li, Z. Lian, X. Liang, C. Lin, T. Lin, R. Lindner, V. Lisovskyi, R. Litvinov, F. L. Liu, G. Liu, H. Liu, K. Liu, Q. Liu, S. Liu, Y. Liu, Y. L. Liu, A. Lobo Salvia, A. Loi, J. Lomba Castro, T. Long, J. H. Lopes, A. Lopez Huertas, S. López Soliño, G. H. Lovell, C. Lucarelli, D. Lucchesi, S. Luchuk, M. Lucio Martinez, V. Lukashenko, Y. Luo, A. Lupato, E. Luppi, K. Lynch, X.-R. Lyu, G. M. Ma, R. Ma, S. Maccolini, F. Machefert, F. Maciuc, B. M. Mack, I. Mackay, L. M. Mackey, L. R. Madhan Mohan, M. M. Madurai, A. Maevskiy, D. Magdalinski, D. Maisuzenko, M. W. Majewski, J. J. Malczewski, S. Malde, B. Malecki, L. Malentacca, A. Malinin, T. Maltsev, G. Manca, G. Mancinelli, C. Mancuso, R. Manera Escalero, D. Manuzzi, D. Marangotto, J. F. Marchand, R. Marchevski, U. Marconi, S. Mariani, C. Marin Benito, J. Marks, A. M. Marshall, P. J. Marshall, G. Martelli, G. Martellotti, L. Martinazzoli, M. Martinelli, D. Martinez Santos, F. Martinez Vidal, A. Massafferri, M. Materok, R. Matev, A. Mathad, V. Matiunin, C. Matteuzzi, K. R. Mattioli, A. Mauri, E. Maurice, J. Mauricio, P. Mayencourt, M. Mazurek, M. McCann, L. Mcconnell, T. H. McGrath, N. T. McHugh, A. McNab, R. McNulty, B. Meadows, G. Meier, D. Melnychuk, M. Merk, A. Merli, L. Meyer Garcia, D. Miao, H. Miao, M. Mikhasenko, D. A. Milanes, A. Minotti, E. Minucci, T. Miralles, S. E. Mitchell, B. Mitreska, D. S. Mitzel, A. Modak, A. Mödden, R. A. Mohammed, R. D. Moise, S. Mokhnenko, T. Mombächer, M. Monk, I. A. Monroy, S. Monteil, A. Morcillo Gomez, G. Morello, M. J. Morello, M. P. Morgenthaler, J. Moron, A. B. Morris, A. G. Morris, R. Mountain, H. Mu, Z. M. Mu, E. Muhammad, F. Muheim, M. Mulder, K. Müller, F. Muñoz-Rojas, R. Murta, P. Naik, T. Nakada, R. Nandakumar, T. Nanut, I. Nasteva, M. Needham, N. Neri, S. Neubert, N. Neufeld, P. Neustroev, R. Newcombe, J. Nicolini, D. Nicotra, E. M. Niel, N. Nikitin, P. Nogga, N. S. Nolte, C. Normand, J. Novoa Fernandez, G. Nowak, C. Nunez, H. N. Nur, A. Oblakowska-Mucha, V. Obraztsov, T. Oeser, S. Okamura, R. Oldeman, F. Oliva, M. Olocco, C. J. G. Onderwater, R. H. O’Neil, J. M. Otalora Goicochea, T. Ovsiannikova, P. Owen, A. Oyanguren, O. Ozcelik, K. O. Padeken, B. Pagare, P. R. Pais, T. Pajero, A. Palano, M. Palutan, G. Panshin, L. Paolucci, A. Papanestis, M. Pappagallo, L. L. Pappalardo, C. Pappenheimer, C. Parkes, B. Passalacqua, G. Passaleva, D. Passaro, A. Pastore, M. Patel, J. Patoc, C. Patrignani, C. J. Pawley, A. Pellegrino, M. Pepe Altarelli, S. Perazzini, D. Pereima, A. Pereiro Castro, P. Perret, A. Perro, K. Petridis, A. Petrolini, S. Petrucci, J. P. Pfaller, H. Pham, L. Pica, M. Piccini, B. Pietrzyk, G. Pietrzyk, D. Pinci, F. Pisani, M. Pizzichemi, V. Placinta, M. Plo Casasus, F. Polci, M. Poli Lener, A. Poluektov, N. Polukhina, I. Polyakov, E. Polycarpo, S. Ponce, D. Popov, S. Poslavskii, K. Prasanth, C. Prouve, V. Pugatch, G. Punzi, W. Qian, N. Qin, S. Qu, R. Quagliani, R. I. Rabadan Trejo, B. Rachwal, J. H. Rademacker, M. Rama, M. Ramírez García, M. Ramos Pernas, M. S. Rangel, F. Ratnikov, G. Raven, M. Rebollo De Miguel, F. Redi, J. Reich, F. Reiss, Z. Ren, P. K. Resmi, R. Ribatti, G. R. Ricart, D. Riccardi, S. Ricciardi, K. Richardson, M. Richardson-Slipper, K. Rinnert, P. Robbe, G. Robertson, E. Rodrigues, E. Rodriguez Fernandez, J. A. Rodriguez Lopez, E. Rodriguez Rodriguez, A. Rogovskiy, D. L. Rolf, A. Rollings, P. Roloff, V. Romanovskiy, M. Romero Lamas, A. Romero Vidal, G. Romolini, F. Ronchetti, M. Rotondo, S. R. Roy, M. S. Rudolph, T. Ruf, M. Ruiz Diaz, R. A. Ruiz Fernandez, J. Ruiz Vidal, A. Ryzhikov, J. Ryzka, J. J. Saborido Silva, R. Sadek, N. Sagidova, N. Sahoo, B. Saitta, M. Salomoni, C. Sanchez Gras, I. Sanderswood, R. Santacesaria, C. Santamarina Rios, M. Santimaria, L. Santoro, E. Santovetti, A. Saputi, D. Saranin, G. Sarpis, M. Sarpis, A. Sarti, C. Satriano, A. Satta, M. Saur, D. Savrina, H. Sazak, L. G. Scantlebury Smead, A. Scarabotto, S. Schael, S. Scherl, A. M. Schertz, M. Schiller, H. Schindler, M. Schmelling, B. Schmidt, S. Schmitt, H. Schmitz, O. Schneider, A. Schopper, N. Schulte, S. Schulte, M. H. Schune, R. Schwemmer, G. Schwering, B. Sciascia, A. Sciuccati, S. Sellam, A. Semennikov, M. Senghi Soares, A. Sergi, N. Serra, L. Sestini, A. Seuthe, Y. Shang, D. M. Shangase, M. Shapkin, R. S. Sharma, I. Shchemerov, L. Shchutska, T. Shears, L. Shekhtman, Z. Shen, S. Sheng, V. Shevchenko, B. Shi, E. B. Shields, Y. Shimizu, E. Shmanin, R. Shorkin, J. D. Shupperd, R. Silva Coutinho, G. Simi, S. Simone, N. Skidmore, R. Skuza, T. Skwarnicki, M. W. Slater, J. C. Smallwood, E. Smith, K. Smith, M. Smith, A. Snoch, L. Soares Lavra, M. D. Sokoloff, F. J. P. Soler, A. Solomin, A. Solovev, I. Solovyev, R. Song, Y. Song, Y. S. Song, F. L. Souza De Almeida, B. Souza De Paula, E. Spadaro Norella, E. Spedicato, J. G. Speer, E. Spiridenkov, P. Spradlin, V. Sriskaran, F. Stagni, M. Stahl, S. Stahl, S. Stanislaus, E. N. Stein, O. Steinkamp, O. Stenyakin, H. Stevens, D. Strekalina, Y. Su, F. Suljik, J. Sun, L. Sun, Y. Sun, P. N. Swallow, K. Swientek, F. Swystun, A. Szabelski, T. Szumlak, M. Szymanski, Y. Tan, S. Taneja, M. D. Tat, A. Terentev, F. Terzuoli, F. Teubert, E. Thomas, D. J. D. Thompson, H. Tilquin, V. Tisserand, S. T’Jampens, M. Tobin, L. Tomassetti, G. Tonani, X. Tong, D. Torres Machado, L. Toscano, D. Y. Tou, C. Trippl, G. Tuci, N. Tuning, L. H. Uecker, A. Ukleja, D. J. Unverzagt, E. Ursov, A. Usachov, A. Ustyuzhanin, U. Uwer, V. Vagnoni, A. Valassi, G. Valenti, N. Valls Canudas, H. Van Hecke, E. van Herwijnen, C. B. Van Hulse, R. Van Laak, M. van Veghel, R. Vazquez Gomez, P. Vazquez Regueiro, C. Vázquez Sierra, S. Vecchi, J. J. Velthuis, M. Veltri, A. Venkateswaran, M. Vesterinen, M. Vieites Diaz, X. Vilasis-Cardona, E. Vilella Figueras, A. Villa, P. Vincent, F. C. Volle, D. vom Bruch, V. Vorobyev, N. Voropaev, K. Vos, G. Vouters, C. Vrahas, J. Walsh, E. J. Walton, G. Wan, C. Wang, G. Wang, J. Wang, M. Wang, N. W. Wang, R. Wang, X. Wang, X. W. Wang, Y. Wang, Z. Wang, J. A. Ward, M. Waterlaat, N. K. Watson, D. Websdale, Y. Wei, B. D. C. Westhenry, D. J. White, M. Whitehead, A. R. Wiederhold, D. Wiedner, G. Wilkinson, M. K. Wilkinson, M. Williams, M. R. J. Williams, R. Williams, F. F. Wilson, W. Wislicki, M. Witek, L. Witola, C. P. Wong, G. Wormser, S. A. Wotton, H. Wu, J. Wu, Y. Wu, K. Wyllie, S. Xian, Z. Xiang, Y. Xie, A. Xu, J. Xu, L. Xu, M. Xu, Z. Xu, D. Yang, S. Yang, X. Yang, Y. Yang, Z. Yang, V. Yeroshenko, H. Yeung, H. Yin, C. Y. Yu, J. Yu, X. Yuan, E. Zaffaroni, M. Zavertyaev, M. Zdybal, M. Zeng, C. Zhang, D. Zhang, J. Zhang, L. Zhang, S. Zhang, Y. Zhang, Y. Z. Zhang, Y. Zhao, A. Zharkova, A. Zhelezov, X. Z. Zheng, Y. Zheng, T. Zhou, X. Zhou, Y. Zhou, V. Zhovkovska, L. Z. Zhu, X. Zhu, Z. Zhu, V. Zhukov, J. Zhuo, Q. Zou, D. Zuliani, and G. Zunica
Subjects: Flavour Physics, Particle and Resonance Production, Rare Decay, Hadron-Hadron Scattering, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract: Abstract The resonant structure of the radiative decay Λ b 0 → pK − γ $$ {\Lambda}_b^0\to {pK}^{-}\gamma $$ in the region of proton-kaon invariant-mass up to 2.5 GeV/c 2 is studied using proton-proton collision data recorded at centre-of-mass energies of 7, 8, and 13 TeV collected with the LHCb detector, corresponding to a total integrated luminosity of 9 fb −1. Results are given in terms of fit and interference fractions between the different components contributing to this final state. Only Λ resonances decaying to pK − are found to be relevant, where the largest contributions stem from the Λ(1520), Λ(1600), Λ(1800), and Λ(1890) states.
Published: 2024
Full Text: View/download PDF

34. TauP301L disengages from the proteosome core complex and neurogranin coincident with enhanced neuronal network excitability

Author: Katriona L. Hole, Bangfu Zhu, Laura Huggon, Jon T. Brown, Jody M. Mason, and Robert J. Williams
Subjects: Cytology, QH573-671
Abstract: Abstract Tauopathies are characterised by the pathological accumulation of misfolded tau. The emerging view is that toxic tau species drive synaptic dysfunction and potentially tau propagation before measurable neurodegeneration is evident, but the underlying molecular events are not well defined. Human non-mutated 0N4R tau (tauWT) and P301L mutant 0N4R tau (tauP301L) were expressed in mouse primary cortical neurons using adeno-associated viruses to monitor early molecular changes and synaptic function before the onset of neuronal loss. In this model tauP301L was differentially phosphorylated relative to tauwt with a notable increase in phosphorylation at ser262. Affinity purification - mass spectrometry combined with tandem mass tagging was used to quantitatively compare the tauWT and tauP301L interactomes. This revealed an enrichment of tauP301L with ribosomal proteins but a decreased interaction with the proteasome core complex and reduced tauP301L degradation. Differences in the interaction of tauP301L with members of a key synaptic calcium-calmodulin signalling pathway were also identified, most notably, increased association with CaMKII but reduced association with calcineurin and the candidate AD biomarker neurogranin. Decreased association of neurogranin to tauP301L corresponded with the appearance of enhanced levels of extracellular neurogranin suggestive of potential release or leakage from synapses. Finally, analysis of neuronal network activity using micro-electrode arrays showed that overexpression of tauP301L promoted basal hyperexcitability coincident with these changes in the tau interactome and implicating tau in specific early alterations in synaptic function.
Published: 2024
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35. Ribosomal DNA copy number is associated with body mass in humans and other mammals

Author: Pui Pik Law, Liudmila A. Mikheeva, Francisco Rodriguez-Algarra, Fredrika Asenius, Maria Gregori, Robert A. E. Seaborne, Selin Yildizoglu, James R. C. Miller, Hemanth Tummala, Robin Mesnage, Michael N. Antoniou, Weilong Li, Qihua Tan, Sara L. Hillman, Vardhman K. Rakyan, David J. Williams, and Michelle L. Holland
Subjects: Science
Abstract: Abstract Body mass results from a complex interplay between genetics and environment. Previous studies of the genetic contribution to body mass have excluded repetitive regions due to the technical limitations of platforms used for population scale studies. Here we apply genome-wide approaches, identifying an association between adult body mass and the copy number (CN) of 47S-ribosomal DNA (rDNA). rDNA codes for the 18 S, 5.8 S and 28 S ribosomal RNA (rRNA) components of the ribosome. In mammals, there are hundreds of copies of these genes. Inter-individual variation in the rDNA CN has not previously been associated with a mammalian phenotype. Here, we show that rDNA CN variation associates with post-pubertal growth rate in rats and body mass index in adult humans. rDNA CN is not associated with rRNA transcription rates in adult tissues, suggesting the mechanistic link occurs earlier in development. This aligns with the observation that the association emerges by early adulthood.
Published: 2024
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36. Lessons learned from bovine subclinical endometritis: a systematic review exploring its potential relevance to chronic endometritis in women

Author: Kaltrina Krasniqi, Naomi Black, Erin J Williams, Osvaldo Bogado Pascottini, Sarah Thornton, Siobhan Quenby, and Joshua Odendaal
Subjects: chronic endometritis, subclinical endometritis, cytological endometritis, one health, gynaecology, bovine, dairy cow, pathophysiology, diagnostic techniques, Reproduction, QH471-489, Gynecology and obstetrics, RG1-991
Abstract: Chronic endometritis (CE) in humans is asymptomatic inflammation of the endometrium, associated with poor reproductive outcomes. Similarly, asymptomatic endometrial inflammation in cows, termed subclinical endometritis (SCE), is associated with adverse reproductive outcomes. While the pathophysiology and treatment options for CE in humans remain poorly defined, the well-known financial implications of SCE in dairy cows have attracted intensive research. We performed a systematic review to determine potential areas of interest in human CE research, by analysing emergent themes that arose in studies of SCE in cows. A literature search for studies of subclinical endometritis in cows published between 1990 and November 2021 was performed across Embase, Medline, Scopus and CINAHL. Studies of symptomatic or clinical endometritis were excluded. A thematic analysis across two broad themes was explored: i) diagnostic methods of SCE and ii) pathophysiology of SCE. In total, 51 bovine studies were included. Twelve studies reported on diagnostic methodology. The primary emergent theme was the use of cytology for the diagnosis of SCE. Cytological analysis has a lower sensitivity than histopathology but is less invasive and more specific than alternative techniques such as ultrasound, vaginoscopy or metabolic markers. The subthemes related to pathophysiology were identified as the type of endometritis, metabolic stress, artificial insemination, infective causes and altered cellular pathways. Despite the lack of symptoms, cellular pathways of inflammation including NF-κB, MAPK and inflammasomes were found to be activated. The key themes related to the diagnosis and pathophysiology of SCE in cows identified in this systematic review highlight potential areas for future research into human CE.
Published: 2024
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37. Three-dimensional reconstruction of high latitude bamboo coral via X-ray microfocus Computed Tomography

Author: Thomas J. Williams, Philip J. Basford, Orestis L. Katsamenis, Martin Solan, Gavin L. Foster, Christopher Standish, Jasmin A. Godbold, and Philippe Archambault
Subjects: Science
Abstract: Abstract The skeletons of long-lived bamboo coral (Family Keratoisididae) are promising archives for deep-water palaeoceanographic reconstructions as they can record environmental variation at sub-decadal resolution in locations where in-situ measurements lack temporal coverage. Yet, detailed three dimensional (3D) characterisations of bamboo coral skeletal architecture are not routinely available and non-destructive investigations into microscale variations in calcification are rare. Here, we provide high-resolution micro-focus computed tomography (µCT) data of skeletal density for two species of bamboo coral (Acanella arbuscula: 5 specimens, voxel size, 15 µm (central branch scans) and 50 µm (complete structure scan); Keratoisis sp.: 4 specimens, voxel size, 15 µm) collected from the Labrador Sea and Baffin Bay deep-water basins, Eastern Canadian Arctic. These data provide reference models useful for developing methods to assess structural integrity and other fine-scale complexities in many biological, geological, and industrial systems. This will be of wider value to those investigating structural composition, arrangement and/or composition of complex architecture within the fields and subdisciplines of biology, ecology, medicine, environmental geology, and structural engineering.
Published: 2024
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38. Evaluating a multifaceted implementation strategy and package of evidence-based interventions based on WHO PEN for people living with HIV and cardiometabolic conditions in Lusaka, Zambia: protocol for the TASKPEN hybrid effectiveness-implementation stepped wedge cluster randomized trial

Author: Michael E. Herce, Samuel Bosomprah, Felix Masiye, Oliver Mweemba, Jessie K. Edwards, Chomba Mandyata, Mmamulatelo Siame, Chilambwe Mwila, Tulani Matenga, Christiana Frimpong, Anchindika Mugala, Peter Mbewe, Perfect Shankalala, Pendasambo Sichone, Blessings Kasenge, Luanaledi Chunga, Rupert Adams, Brian Banda, Daniel Mwamba, Namwinga Nachalwe, Mansi Agarwal, Makeda J. Williams, Veronica Tonwe, Jake M. Pry, Maurice Musheke, Michael Vinikoor, and Wilbroad Mutale
Subjects: Non-communicable diseases, HIV/AIDS, Hypertension, Diabetes, Dyslipidemia, Task shifting, Medicine (General), R5-920
Abstract: Abstract Background Despite increasing morbidity and mortality from non-communicable diseases (NCD) globally, health systems in low- and middle-income countries (LMICs) have limited capacity to address these chronic conditions, particularly in sub-Saharan Africa (SSA). There is an urgent need, therefore, to respond to NCDs in SSA, beginning by applying lessons learned from the first global response to any chronic disease—HIV—to tackle the leading cardiometabolic killers of people living with HIV (PLHIV). We have developed a feasible and acceptable package of evidence-based interventions and a multi-faceted implementation strategy, known as “TASKPEN,” that has been adapted to the Zambian setting to address hypertension, diabetes, and dyslipidemia. The TASKPEN multifaceted implementation strategy focuses on reorganizing service delivery for integrated HIV-NCD care and features task-shifting, practice facilitation, and leveraging HIV platforms for NCD care. We propose a hybrid type II effectiveness-implementation stepped-wedge cluster randomized trial to evaluate the effects of TASKPEN on clinical and implementation outcomes, including dual control of HIV and cardiometabolic NCDs, as well as quality of life, intervention reach, and cost-effectiveness. Methods The trial will be conducted in 12 urban health facilities in Lusaka, Zambia over a 30-month period. Clinical outcomes will be assessed via surveys with PLHIV accessing routine HIV services, and a prospective cohort of PLHIV with cardiometabolic comorbidities nested within the larger trial. We will also collect data using mixed methods, including in-depth interviews, questionnaires, focus group discussions, and structured observations, and estimate cost-effectiveness through time-and-motion studies and other costing methods, to understand implementation outcomes according to Proctor’s Outcomes for Implementation Research, the Consolidated Framework for Implementation Research, and selected dimensions of RE-AIM. Discussion Findings from this study will be used to make discrete, actionable, and context-specific recommendations in Zambia and the region for integrating cardiometabolic NCD care into national HIV treatment programs. While the TASKPEN study focuses on cardiometabolic NCDs in PLHIV, the multifaceted implementation strategy studied will be relevant to other NCDs and to people without HIV. It is expected that the trial will generate new insights that enable delivery of high-quality integrated HIV-NCD care, which may improve cardiovascular morbidity and viral suppression for PLHIV in SSA. This study was registered at ClinicalTrials.gov (NCT05950919).
Published: 2024
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39. Dissemination and implementation research coordination and training to improve cardiovascular health in people living with HIV in sub-Saharan Africa: the research coordinating center of the HLB-SIMPLe Alliance

Author: Emmanuel K. Tetteh, William Effah, Lisa de las Fuentes, Karen Steger-May, Charles W. Goss, David W. Dowdy, Mark D. Huffman, Makeda J. Williams, Veronica Tonwe, Geetha P. Bansal, Elvin H. Geng, Victor G. Dávila-Román, Treva Rice, and Kenneth B Schechtman
Subjects: Capacity building, Implementation science, Cardiovascular Health, Cardiovascular Disease, Hypertension, HIV/AIDS, Medicine (General), R5-920
Abstract: Abstract As global adoption of antiretroviral therapy extends the lifespan of People Living with HIV (PLHIV) through viral suppression, the risk of comorbid conditions such as hypertension has risen, creating a need for effective, scalable interventions to manage comorbidities in PLHIV. The Heart, Lung, and Blood Co-morbiditieS Implementation Models in People Living with HIV (HLB-SIMPLe) Alliance has been funded by the National Heart, Lung, and Blood Institute (NHLBI) and the Fogarty International Center (FIC) since September 2020. The Alliance was created to conduct late-stage implementation research to contextualize, implement, and evaluate evidence-based strategies to integrate the diagnosis, treatment, and control of cardiovascular diseases, particularly hypertension, in PLHIV in low- and middle-income countries (LMICs). The Alliance consists of six individually-funded clinical trial cooperative agreement research projects based in Botswana, Mozambique, Nigeria, South Africa, Uganda, and Zambia; the Research Coordinating Center; and personnel from NIH, NHLBI, and FIC (the Federal Team). The Federal Team works together with the members of the seven cooperative agreements which comprise the alliance. The Federal Team includes program officials, project scientists, grant management officials and clinical trial specialists. This Alliance of research scientists, trainees, and administrators works collaboratively to provide and support venues for ongoing information sharing within and across the clinical trials, training and capacity building in research methods, publications, data harmonization, and community engagement. The goal is to leverage shared learning to achieve collective success, where the resulting science and training are greater with an Alliance structure rather than what would be expected from isolated and unconnected individual research projects. In this manuscript, we describe how the Research Coordinating Center performs the role of providing organizational efficiencies, scientific technical assistance, research capacity building, operational coordination, and leadership to support research and training activities in this multi-project cooperative research Alliance. We outline challenges and opportunities during the initial phases of coordinating research and training in the HLB-SIMPLe Alliance, including those most relevant to dissemination and implementation researchers.
Published: 2024
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40. Dose escalation of tolinapant (ASTX660) in combination with standard radical chemoradiotherapy in cervical cancer : a study protocol for a phase 1b TiTE-CRM clinical trial (CRAIN) in UK secondary care centres

Author: Peter Hoskin, Marina Lee, Denise Dunkley, Mary Danh, Robin Wickens, Geoff Saunders, Josh Northey, Simon Crabb, Vicky McFarlane, Azmat Sadozye, Rachel Cooper, Tony Mathew, Kate Haslett, Kim Reeves, Rachel Reed, Kamilla Bigos, Kaye J. Williams, Emily Rowling, Ananya Choudhury, Sonia Dancer, Deb Smith, and Gareth Griffiths
Subjects: Cervical cancer, Tolinapant, Chemoradiotherapy, Cisplatin, Phase I, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract: Abstract Background Cervical cancer is the fourth most common cancer in women, with an estimated 342,000 deaths worldwide in 2020. Current standard of care in the UK for locally advanced cervical cancer is concurrent chemoradiotherapy with weekly cisplatin, yet 5-year overall survival rates are only 65% with a distant relapse rate of 50%. Inhibitors of Apoptosis Proteins (IAPs) are often overexpressed in cancer cells and associated with tumour progression and resistance to treatment. Tolinapant, developed by Astex Pharmaceuticals, is an IAP antagonist with an additional mechanism of action via down-regulation of NF-kB, an important regulator in cervical cancer. Preclinical studies performed using tolinapant in combination with cisplatin and radiotherapy showed inhibition of tumour growth and enhanced survival. There is therefore a strong rationale to combine tolinapant with chemoradiotherapy (CRT). Methods CRAIN is a phase Ib open-label, dose escalation study to characterise the safety, tolerability and initial evidence for clinical activity of tolinapant when administered in combination with cisplatin based CRT. Up to 42 patients with newly diagnosed cervix cancer will be recruited from six UK secondary care sites. The number of participants and the duration of the trial will depend on toxicities observed and dose escalation decisions, utilising a TiTE-CRM statistical design. Treatment will constist of standard of care CRT with 45 Gy external beam radiotherapy given in 25 daily fractions over 5 weeks with weekly cisplatin 40mg/m2. This is followed by brachytherapy for which common schedules will be 28 Gy in 4 fractions high-dose-rate or 34 Gy in 2 fractions pulsed-dose-rate. Tolinapant will be administered in fixed dose capsules taken orally daily for seven consecutive days as an outpatient on alternate weeks (weeks 1, 3, 5) during chemoradiation. Dose levels for tolinapant which will be assessed are: 60 mg; 90 mg (starting level); 120 mg; 150 mg; 180 mg. Escalation will be guided by emerging safety data and decisions by the Safety Review Committee. Discussion If this trial determines a recommended phase II dose and shows tolinapant to be safe and effective in combination with CRT, it would warrant future phase trials. Ultimately, we hope to provide a synergistic treatment option for these patients to improve outcome. Trial registrations EudraCT Number: 2021-006555-34 (issued 30th November 2021); ISRCTN18574865 (registered 30th August 2022).
Published: 2024
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41. Effects of pyrolysis temperature on the photooxidation of water-soluble fraction of wheat straw biochar based on 21 T FT-ICR mass spectrometry

Author: Amy M. McKenna, Martha L. Chacón-Patiño, Holly K. Roth, William Bahureksa, Robert B. Young, James A. Ippolito, Yan Xin, Thomas Borch, Antony J. Williams, and Huan Chen
Subjects: Photoreactive organic matter, Molecular composition, Toxicity assessment, Highly oxidized OC, Surface morphology, Soil organic matter, Environmental sciences, GE1-350, Public aspects of medicine, RA1-1270
Abstract: Biochar, formed through the pyrolysis or burning of organic wastes, has a complex chemical composition influenced by feedstock, pyrolysis temperature, and reaction conditions. Water-soluble, dissolved black carbon species released from biochar comprise one of the most photoreactive organic matter fractions. Photodegradation of these water-soluble species from wheat straw biochar, produced at different pyrolysis temperatures in laboratory microcosms, resulted in noticeable compositional differences. This study characterized water-soluble transformation products formed through the photodegradation of wheat straw biochar pyrolyzed at 300, 400, 500, or 600°C by electrospray ionization 21 T Fourier transform ion cyclotron resonance mass spectrometry (21T FT-ICR MS). We also evaluated global trends in the toxicity of these water-soluble fractions using MicroTox™ to assess the impacts of pyrolysis temperature. Additionally, we examined biochar surface morphology after photodegradation and observed minimal change after irradiation for 48 h, though the total yield of water-soluble biochar species varied with pyrolysis temperature. Trends in toxicity observed from MicroTox® analysis reveal that water-soluble photoproducts from biochar produced at 300°C and 900°C are nearly three times as toxic compared to dark controls. The ultrahigh resolving power of 21T FT-ICR MS allows for the separation of tens of thousands of highly oxidized, low-molecular-weight (
Published: 2024
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42. The Validity of Impressions as a Media Dose Metric in a Tobacco Public Education Campaign Evaluation: Observational Study

Author: Kevin Davis, Laurel Curry, Brian Bradfield, David A Stupplebeen, Rebecca J Williams, Sandra Soria, and Julie Lautsch
Subjects: Computer applications to medicine. Medical informatics, R858-859.7, Public aspects of medicine, RA1-1270
Abstract: BackgroundEvaluation research increasingly needs alternatives to target or gross rating points to comprehensively measure total exposure to modern multichannel public education campaigns that use multiple channels, including TV, radio, digital video, and paid social media, among others. Ratings data typically only capture delivery of broadcast media (TV and radio) and excludes other channels. Studies are needed to validate objective cross-channel metrics such as impressions against self-reported exposure to campaign messages. ObjectiveThis study aimed to examine whether higher a volume of total media campaign impressions is predictive of individual-level self-reported campaign exposure in California. MethodsWe analyzed over 3 years of advertisement impressions from the California Tobacco Prevention Program’s statewide tobacco education campaigns from August 2019 through December 2022. Impressions data varied across designated market areas (DMAs) and across time. These data were merged to individual respondents from 45 waves of panel survey data of Californians aged 18-55 years (N=151,649). Impressions were merged to respondents based on respondents’ DMAs and time of survey completion. We used logistic regression to estimate the odds of respondents’ campaign recall as a function of cumulative and past 3-month impressions delivered to each respondent’s DMA. ResultsCumulative impressions were positively and significantly associated with recall of each of the Flavors Hook Kids (odds ratio [OR] 1.15, P
Published: 2024
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43. Intraductal papilloma presenting as a breast mass in an 8-month-Old male infant: A case report

Author: Maen Kamal, Nesma Ghanim, Raima Hashmi, Zachary Patterson, Qazi Azher, and Antonio J. Williams Sr
Subjects: Male infant, Breast intraductal papilloma, Case report, Pediatrics, RJ1-570, Surgery, RD1-811
Abstract: Introduction: Intraductal papilloma is an exceptionally rare condition in the pediatric population, particularly among males in infancy and early childhood, typically most prevalent among women aged between 35 and 55 years presenting as sanguineous or serosanguineous nipple discharge and a discrete breast mass. Despite its historical classification as benign, emerging research indicates a potential for malignant transformation, prompting a reevaluation of its clinical significance. Case presentation: We present the case of a healthy 8-month-old male infant with a right subareolar breast swelling that appeared non tender, well-circumscribed, smooth, mobile, rubbery, without any associated nipple discharge or regional lymphadenopathy, clinically measuring 10 × 10 mm in diameter, and exhibited a bluish green hue with no associated changes in overlying skin. Ultrasound confirmed presence of a right retro areolar breast mass, characterized as a multiseptated complex cyst-like structure with tubular anechoic formations within, measuring 21 x 20 × 6 mm. The findings were suggestive of possible duct ectasia classified as Bi-Rads Category 3 with a benign probability. Due to parental concern for increase in size over 2 months, the mass was resected under general anesthesia through a subareolar incision. Microscopic analysis confirmed dilated cystic ducts and an intraductal papilloma with calcifications. The patient recovered well from the operation, and follow-up at nine months, he has experienced no recurrences. Conclusion: Although rare, this case underscores the importance of including intraductal papilloma in the differential diagnosis of breast nodules in male infants.
Published: 2024
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44. The emerging role of a Stroke Clinical Nurse Specialist (CNS) in Early Supported Discharged: Developing a pathway for stroke nursing for secondary prevention in the community. A scoping review protocol. [version 2; peer review: 1 approved, 2 approved with reservations]

Author: Frances Horgan, Sarah-Jane Byrne, Declan Patton, David J. Williams, and Paul J. Murphy
Subjects: Early Supported Discharge, Stroke Clinical Nurse Specialist, Stroke Rehabilitation, Community Care, Primary Care, Scoping Review, eng, Medicine
Abstract: Background Stroke represents a major source of mortality and morbidity globally. The role of a stroke Clinical Nurse Specialist (CNS) as an expert team member in early supported discharge (ESD) for stroke, is not well defined or described although it is well established in other models of after-hospital and out-reach specialist care in the community. A greater focus has been on patients receiving rehabilitation post-stroke, however there is a need for a more holistic approach to care which clinical nurse specialists can offer to patients as part of ESD. Nurses are often the cohesive point of contact for other after-hospital services, managing many aspects of secondary prevention. Objective The aim of this scoping review is to explore the evidence in relation to the role of the stroke nurse providing secondary prevention interventions to stroke patients in a community setting. Methods We will conduct a scoping review in accordance with the Arksey and O’Malley, 2005 1 scoping review framework and the PRISMA-ScR guidelines to map available literature on the role of the stroke nurse in post-stroke care of patients in the community. The Cochrane Central Register of Controlled Trials and Systematic literature searches including databases MEDLINE, EMBASE, CINAHL, google scholar and grey literature will be searched using keyword searches. Data will be charted and synthesised and a narrative synthesis will be conducted. Conclusions This scoping review will be used to identify gaps in the current literature and identify areas for future research in the role of the stroke nurse in ESD in relation to secondary prevention for stroke patients and inform the development of a pathway for stroke nursing in ESD.
Published: 2024
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45. Interventions for people with perceptual disorders after stroke: the PIONEER scoping review, Cochrane systematic review and priority setting project

Author: Christine Hazelton, Alex Todhunter-Brown, Pauline Campbell, Katie Thomson, Donald J Nicolson, Kris McGill, Charlie SY Chung, Liam Dorris, David C Gillespie, Susan M Hunter, Linda J Williams, and Marian C Brady
Subjects: (from mesh) stroke, survivors, perception, perceptual disorders, grade approach, rehabilitation, systematic review, Medical technology, R855-855.5
Abstract: Background Stroke often affects recognition and interpretation of information from our senses, resulting in perceptual disorders. Evidence to inform treatment is unclear. Objective To determine the breadth and effectiveness of interventions for stroke-related perceptual disorders and identify priority research questions. Methods We undertook a scoping review and then Cochrane systematic review. Definitions, outcome prioritisation, data interpretation and research prioritisation were coproduced with people who had perceptual disorders post stroke and healthcare professionals. We systematically searched electronic databases (including MEDLINE, EMBASE, inception to August 2021) and grey literature. We included studies (any design) of interventions for people with hearing, smell, somatosensation, taste, touch or visual perception disorders following stroke. Abstracts and full texts were independently dual reviewed. Data were tabulated, synthesised narratively and mapped by availability, sense and interventions. Research quality was not evaluated. Our Cochrane review synthesised the randomised controlled trial data, evaluated risk of bias (including randomisation, blinding, reporting) and meta-analysed intervention comparisons (vs. controls or no treatment) using RevMan 5.4. We judged certainty of evidence using grading of recommendations, assessment, development and evaluation. Activities of daily living after treatment was our primary outcome. Extended activities of daily living, quality of life, mental health and psychological well-being perceptual functional and adverse event data were also extracted. Results Scoping review We included 80 studies (n = 893): case studies (36/80) and randomised controlled trials (22/80). No stroke survivor or family stakeholder involvement was reported. Studies addressed visual (42.5%, 34/80), somatosensation (35%, 28/80), auditory (8.7%, 7/80) and tactile (7.5%, 6/80) perceptual disorders; some studies focused on ‘mixed perceptual disorders’ (6.2%, 5/80 such as taste–smell disorders). We identified 93 pharmacological, non-invasive brain stimulation or rehabilitation (restitution, substitution, compensation or mixed) interventions. Details were limited. Studies commonly measured perceptual (75%, 60/80), motor-sensorimotor (40%, 32/80) activities of daily living (22.5%, 18/80) or sensory function (15%, 12/80) outcomes. Cochrane systematic review We included 18 randomised controlled trials (n = 541) addressing tactile (3 randomised controlled trials; n = 70), somatosensory (7 randomised controlled trials; n = 196), visual (7 randomised controlled trials; n = 225) and mixed tactile-somatosensory (1 randomised controlled trial; n = 50) disorders. None addressed hearing, taste or smell disorders. One non-invasive brain stimulation, one compensation, 25 restitution and 4 mixed interventions were described. Risk of bias was low for random sequence generation (13/18), attrition (14/18) and outcome reporting (16/18). Perception was the most commonly measured outcome (11 randomised controlled trials); only 7 randomised controlled trials measured activities of daily living. Limited data provided insufficient evidence to determine the effectiveness of any intervention. Confidence in the evidence was low–very low. Our clinical (n = 4) and lived experience (n = 5) experts contributed throughout the project, coproducing a list of clinical implications and research priorities. Top research priorities included exploring the impact of, assessment of, and interventions for post-stroke perceptual disorders. Limitations Results are limited by the small number of studies identified and the small sample sizes, with a high proportion of single-participant studies. There was limited description of the perceptual disorders and intervention(s) evaluated. Few studies measured outcomes relating to functional impacts. There was limited investigation of hearing, smell, taste and touch perception disorders. Conclusion Evidence informing interventions for perceptual disorders after stroke is limited for all senses. Future work Further research, including high-quality randomised controlled trials, to inform clinical practice are required. Study registration This study is registered as PROSPERO CRD42019160270. Funding This award was funded by the National Institute for Health and Care Research (NIHR) Health Technology Assessment programme (NIHR award ref: NIHR128829) and is published in full in Health Technology Assessment; Vol. 28, No. 69. See the NIHR Funding and Awards Website for further award information. Plain language summary After a stroke, individuals may have difficulty understanding information gathered through their sense of sight, hearing, smell, taste, touch or somatosensation (body position, temperature, etc.), known as perceptual problems. We estimate perceptual problems affect around 240,000 stroke survivors in the UK, limiting their ability to understand the world around them, affecting everyday activities and reducing quality of life. Healthcare professionals may offer different treatments; medicine, brain stimulation, or rehabilitation activities including puzzles, strategies or physical therapy. We wanted to find the best treatments for stroke-related perceptual problems. We searched for all research on sight, hearing, smell, taste, touch and somatosensation perceptual treatments to find out (1) how well they worked, (2) what the research means for stroke survivors and healthcare professionals and (3) what research is needed next. People with stroke-related perceptual problems and healthcare experts produced this research together. We found 80 studies, involving 893 stroke survivors, describing 93 treatments. Eighteen of these studies used higher-quality randomised controlled trial designs; 535 stroke survivors took part, testing 32 treatments. Randomised controlled trials are important as one-half of those involved receive treatment and one-half do not; they provide the best evidence about whether a treatment works. Most treatments were for visual or somatosensation problems. Each study was small, provided few details about the participants or their treatment, and tested very different treatments. Few measured the effect of treatment on everyday life: only seven measured stroke survivors’ ability to take part in everyday activities. No trial asked stroke survivors about their experiences with the treatments offered. We do not have enough research to identify which treatments benefit the lives of people with stroke-related perceptual problems. We need more research into perceptual problems, especially the impact it has on stroke survivors’ lives, as well as bigger studies into well-described treatments, that measure the impact of the treatment on people’s lives. Scientific summary Background Perception is the synthesis and interpretation of information gathered through the senses: hearing, taste, touch, smell, visual and information on temperature, pressure, vibration and body position, known as somatosensation. Up to a fifth of stroke survivors experience perceptual disorders after stroke, limiting their ability to perceive and process sensory information and reducing their ability to take part in daily activities. To date, the effectiveness of perceptual disorder interventions after stroke is unclear. Clinical guidelines offer limited recommendations. Stroke survivors, carers and healthcare professionals have stated that improving research into perception is important to them. Further, it is important to systematically identify evidence gaps and future research priorities. Objectives We aimed to: Identify all published and unpublished research evaluating interventions for perceptual disorders after stroke, providing a comprehensive report on the scope and nature of the evidence to date and highlighting the research gaps identified. Synthesise and appraise the quality of randomised controlled trial (RCT) evidence of the effectiveness of perceptual disorder interventions after stroke. Understand the implications of our findings for stroke survivors and HCPs working in this area and to determine future research priorities. Methods Our project included a scoping review, the revision and expansion of a Cochrane systematic review and we worked with a Lived Experience Group and a Clinical Expert Group to co-create research recommendations and identify research priorities. Our scoping review of the literature was based on a systematic search of several electronic databases including MEDLINE, EMBASE and CINAHL (inception to August 2021), as well as searches of grey literature, contacting experts and forward citation tracking. We included studies of any design which explored interventions for stroke survivors with hearing, smell, somatosensation, taste, touch or visual perception disorders. Eligible abstracts and full texts were independently reviewed by two reviewers; data were extracted, tabulated and narratively synthesised. Data availability and outcome measures used were mapped. In keeping with scoping review methodology, we did not formally assess research quality. We updated a Cochrane systematic review, including RCTs of adult stroke survivors with perceptual disorders. We assessed the risk of bias, conducted meta-analyses to explore effectiveness of interventions and judged our confidence in the findings using grading quality of evidence and strength of recommendations (GRADE). Outcomes were measured using activities of daily living (ADLs) with extended activities of daily living (EADLs), quality of life, mental health, perceptual function and adverse events data also collated. Using structured involvement and priority setting approaches we worked in partnership with our Lived Experience and Clinical Expert Groups to agree clinical implications and to future research priorities. Results This project was coproduced with people with lived experience of stroke and perceptual disorders (n = 5) and relevant multidisciplinary clinical expertise (n = 4). Working in partnership with the core research team, these groups informed the project throughout, agreeing definitions of perception, relevant outcome measures, clinical implications and priorities for future research. Scoping review Of 91,869 records screened, we included 80 studies (including 36 case reports; 22 RCTs) in the scoping review, most (64%) of which were published in the previous decade. Participants (n = 893) were predominately adults and male; five children were included. Studies generally had small sample sizes, with RCTs accounting for most participants (70.5%; 630/893). The perceptual disorders represented included visual (43%), somatosensory (35%), auditory (9%), tactile (8%) or ‘mixed’ disorders (5%) which included one study on taste–smell disorders. We identified 93 interventions including rehabilitation (84%), pharmacological (6.5%) and non-invasive brain stimulation (NIBS) interventions (7.5%); no surgical or assessment-based interventions were identified. Intervention details were limited. Outcome measures commonly included perceptual function (75%), motor/sensorimotor (40%), ADLs (23%) or sensation (15%). No data on discharge destination, health economic, feasibility, educational (children), psychological well-being and mental health, quality of life, or activity and participation were reported. Time points were typically immediately after the intervention (39%) or within 3 months follow-up with just 15% of studies capturing outcomes beyond that time point. Cochrane systematic review Drawing on the scoping review results, the trials identified in a previous Cochrane Review and an updated search of bibliographic databases, 2575 records were identified. From these, 114 full texts were considered and 18 RCTs (n = 541) were included. All but six were stroke survivors, between 19 days and 4.3 years from onset. The interventions included targeted visual (seven RCTs; n = 225), tactile (three RCTs; n = 70), somatosensory (seven RCTs; n = 196) and one mixed tactile-somatosensory disorders (one RCT; n = 50). No RCT evaluated interventions for stroke-related hearing, taste or smell disorders. Interventions included 1 NIBS, 1 compensatory, 25 restitution, 4 mixed and 1 unclear intervention approach. Seven included RCTs (39%) measured participants’ ADLs though others captured perception (11 RCTs), adverse events (6 RCTs), mobility (4 RCTs) and EADLs (1 RCT). None measured activity and participation, quality of life or psychological well-being and mental health outcomes. We identified 11 ongoing RCTs. The risk of bias of the included RCTs varied, with 72% describing adequate generate of the randomisation sequence and outcome assessor blinding, but concealment of allocation was considered adequate for only a third. Most trials adequately reported participant attrition (78%) and the outcome data gathered (89%). Other sources of bias were noted including an imbalance between the groups at baseline and altered eligibility criteria mid-RCT. With limited data there was insufficient evidence to determine the effectiveness of any one intervention compared to no intervention or an alternative intervention. Based on the small number of RCTs, the small sample sizes and the limited comparisons available, our confidence in the evidence was, using GRADE, judged to be low–very low. Strengths Throughout this project, a Lived Experience and Clinical Expert Group were centrally involved in the development of definitions, categorisation, outcome measurement selection, interpretation of data and research prioritisation, supporting clinical relevance and validity. The consensus working definitions and categorisations developed may support future research on this topic area. Our scoping and systematic reviews were conducted to the highest research conduct and reporting standards. Limitations Despite large numbers of people experiencing one or more perceptual disorder after stroke, there is a striking lack of relevant research to inform interventions. What little has been reported is often based on a single participant or small sample sizes. There is limited description of the perceptual disorder, the intervention(s) evaluated and a focus on perception outcomes rather than measures that reflect the functional impacts described by the Lived Experience Group, for example ADLs. We also found evidence of under-researched subpopulations including children and people with hearing, taste and smell perceptual disorders. The project team, Lived Experience and Clinical Expert Groups are UK-based, and it is unclear whether our priorities (outlined below) capture the wider international picture. Priority setting Our clinical expert (n = 4) and lived experience (n = 5) stakeholders’ input was pivotal throughout the project. Together with the core research team, these groups agreed the clinical implications and research priorities emerging from the findings. Implications for health care Clinical recommendations include the facilitation of improved awareness of stroke-related perceptual disorders, assessment and information provision and holistic intervention approaches and support. While the research evidence was insufficient to support clinical decision-making relating to the choice of intervention approach, the scoping review provides an important information resource for clinicians developing best practice until sufficient evidence becomes available. Recommendations for research The evidence informing interventions for perceptual disorders after stroke is limited, and absent for smell, taste and tactile disorders. Future research should prioritise (1) exploration of the lived experience of people with stroke-related perceptual disorders, (2) improving assessments of stroke-related perceptual disorders, (3) exploring interventions in a way that reflects real-world needs, (4) exploring current clinical practices that address perceptual disorders following stroke and (5) establishing the prevalence of perceptual disorders after stroke. Conclusions Healthcare professionals lack high-quality evidence of effective interventions to inform their provision of advice, treatment and education of stroke survivors with perceptual disorders and their families. Evidence informing these research priority topic areas is urgently required. Study registration This study is registered as PROSPERO CRD42019160270. Funding This award was funded by the National Institute for Health and Care Research (NIHR) Health Technology Assessment programme (NIHR award ref: NIHR128829) and is published in full in Health Technology Assessment; Vol. 28, No. 69. See the NIHR Funding and Awards Website for further award information.
Published: 2024
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46. Falls and fall-related injuries: prevalence, characteristics, and treatment among participants of the Geelong Osteoporosis Study

Author: Tewodros Yosef, Julie A. Pasco, Monica C. Tembo, Lana J. Williams, and Kara L. Holloway-Kew
Subjects: falls, fall-related injuries, Geelong Osteoporosis Study, older adults, population based sample, Public aspects of medicine, RA1-1270
Abstract: BackgroundFalls are a significant public health challenge, especially among older adults. In Australia, falls and related injuries incur an annual cost of $2.3 billion. However, there is a scarcity of prevalence data on falls among population-based groups. This study aimed to report the characteristics, circumstances, and treatment for falls and fall-related injuries in a population-based sample of Australian men and women.MethodsParticipants from the Geelong Osteoporosis Study provided cross-sectional data: baseline for men (2001–2006) and 10-year follow-up for women (2004–2008). Falls over the previous 12 months were self-reported by 2,631 participants aged 20–97 years (1,533 men and 1,098 women). The study described the timing, location, cause, and treatment of falls. Fall prevalence was standardized to the 2006 Australian population. Data collection included self-reported prior fractures, medication, disease conditions, anthropometry, and biochemical tests. Binary logistic regression identified factors linked to fall-related injuries.ResultsFall rates by age group: 20–29 (24.4%), 30–39 (21.5%), 40–49 (18.7%), 50–59 (24.9%), 60–69 (25.0%), 70–79 (34.6%), 80+ (40.5%). The age-standardized prevalence of falls was 25.0% (95% CI: 23.4–26.7%). In adults ≥65 years, the age-standardized prevalence of falls was 32.4% (95% CI: 29.3–35.5%). Fallers were typically older, less mobile, had higher BMI and cholesterol levels, and were more likely to have musculoskeletal conditions, cancer, and polypharmacy. Men had a higher fall risk, but fewer fall-related fractures compared to women. Most falls occurred outdoors (62.1%), were due to extrinsic cause (58.5%), and were on the same level (78.5%). Factors associated with fall-related injuries included being female, elevated falls and falls outside the home. Nearly half (45.7%) of those injured sought medical attention, primarily from general practitioners (25.7%) and emergency departments (12.6%).ConclusionFalls are common, occurring in approximately one quarter of adults in this study, with a greater prevalence among those ≥65 years. Women experienced fewer multiple falls than men. Many participants sought medical attention, primarily from general practitioners. This research identifies fall characteristics and circumstances, informing targeted prevention strategies to reduce occurrences and alleviate burdens on healthcare systems and individuals.
Published: 2024
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47. Autism likelihood in infants born to mothers with asthma is associated with blood inflammatory gene biomarkers in pregnancy

Author: Vanessa E. Murphy, Olivia M. Whalen, Evan J. Williams, Peter G. Gibson, Linda E. Campbell, Frini Karayanidis, Carly A. Mallise, Alix Woolard, Annelies L. Robijn, Joerg Mattes, Adam M. Collison, Alison E. Lane, and Katherine J. Baines
Subjects: Inflammation, Gene expression, Offspring, Sensory regulation, Social communication, Biomarkers, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract: Mothers with asthma or atopy have a higher likelihood of having autistic children, with maternal immune activation in pregnancy implicated as a mechanism. This study aimed to determine, in a prospective cohort of mothers with asthma and their infants, whether inflammatory gene expression in pregnancy is associated with likelihood of future autism.Mothers with asthma were recruited to the Breathing for Life Trial. RNA was extracted from blood samples collected at mid-pregnancy. 300 ng total RNA was hybridized with the nCounter Human Inflammation gene expression panel (Nanostring Technologies, 249 inflammation-related genes). Parents completed the First Year Inventory (FYI) at 12-month follow-up, which assessed an infant's likelihood for autism across 2 behavioural domains: social communication and sensory regulation. A total score ≥19.2 indicated increased likelihood for future autism.Inflammatory gene expression was profiled from 24 mothers: four infants scored in the high autism likelihood range; 20 scored in the low autism likelihood range. Six inflammatory genes were differentially expressed and significantly up-regulated in the high autism likelihood group: CYSLTR2, NOX1, C1QA, CXCL10, C8A, IL23R. mRNA count significantly correlated with social communication FYI score for CYSLTR2 (Pearson r = 0.46, p = 0.024) and CXCL10 (r = 0.43, p = 0.036) and with sensory regulation score for ALOX5 (r = −0.43, p = 0.038) and MAFK (r = −0.46, p = 0.022).In this proof-of-concept study, inflammatory gene expression during pregnancy in mothers with asthma was associated with an infant's likelihood of future autism as well as scores relating to social communication and sensory regulation.
Published: 2024
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48. Osteochondral autograft and allograft for knee cartilage injuries—an international Delphi consensus statement

Author: Frederic Baker Mills, IV, Eoghan T. Hurley, Richard M. Danilkowicz, Robert H. Brophy, Brian J. Cole, Fares S. Haddad, Laszlo Hangody, Gilbert Moatshe, Riley J. Williams, III, and Rachel M. Frank
Subjects: Consensus, Delphi, Knee cartilage, Osteochondral allograft, Osteochondral autograft, Diseases of the musculoskeletal system, RC925-935, Other systems of medicine, RZ201-999, Sports medicine, RC1200-1245
Abstract: Introduction: Articular cartilage injuries of the knee are a complex and challenging clinical pathology. Objectives: The purpose of this study was to establish consensus statements via a Delphi process on osteochondral autograft (OATS) and osteochondral allograft (OCA) in the setting of cartilage defects in the knee. Methods: A consensus process on knee cartilage injuries utilizing a modified Delphi technique was conducted. Seventy-nine surgeons across 17 countries participated in these consensus statements. Twenty-seven questions were generated on OATS and OCA, with 3 rounds of questionnaires and final voting occurring. Consensus was defined as achieving 80% to 89% agreement, whereas strong consensus was defined as 90% to 99% agreement, and unanimous consensus was defined as 100% agreement with a proposed statement. Results: Of the 27 total questions and consensus statements on OATS and OCA developed from 3 rounds of voting, 0 achieved unanimous consensus, 11 achieved strong consensus, 7 achieved consensus, and 9 did not achieve consensus. Conclusions: The statements that achieved strong consensus pertained to the contraindications of OATS and OCA, the preferred site for harvest, storage conditions and timeframe for grafting, site preparation, surgical approach, graft step-off, impact of multiple grafts on clinical outcome, and ways to minimize complications. The statements that did not reach consensus regarded indications for OATS, locations for OATS and OCA, backfilling, sizing, supplemental fixation, marrow venting, and the use of orthobiologics for OCA.
Published: 2024
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49. The prognostic effect of mechanical, ultrastructural, and ECM signatures in glioblastoma core and rim

Author: Bradley J. Mahaffey, Zachary P. Fowler, Zoe Lung, Vivien Dang, Hyunchul Lee, Allison McKenzie Johnson, Marco A. Munoz, Dylan A. Goodin, Hermann B. Frieboes, Brian J. Williams, and Joseph Chen
Subjects: Biotechnology, TP248.13-248.65, Medical technology, R855-855.5
Abstract: Glioblastoma (GBM) is a highly invasive, aggressive brain cancer that carries a median survival of 15 months and is resistant to standard therapeutics. Recent studies have demonstrated that intratumoral heterogeneity plays a critical role in promoting resistance by mediating tumor adaptation through microenvironmental cues. GBM can be separated into two distinct regions—a core and a rim, which are thought to drive specific aspects of tumor evolution. These differences in tumor progression are regulated by the diverse biomolecular and biophysical signals in these regions, but the acellular biophysical characteristics remain poorly described. This study investigates the mechanical and ultrastructural characteristics of the tumor extracellular matrix (ECM) in patient-matched GBM core and rim tissues. Seven patient-matched tumor core and rim samples and one non-neoplastic control were analyzed using atomic force microscopy, scanning electron microscopy, and immunofluorescence imaging to quantify mechanical, ultrastructural, and ECM composition changes. The results reveal significant differences in biophysical parameters between GBM core, rim, and non-neoplastic tissues. The GBM core is stiffer, denser, and is rich in ECM proteins hyaluronic acid and tenascin-C when compared to tumor rim and non-neoplastic tissues. These alterations are intimately related and have prognostic effect with stiff, dense tissue correlating with longer progression-free survival. These findings reveal new insights into the spatial heterogeneity of biophysical parameters in the GBM tumor microenvironment and identify a set of characteristics that may correlate with patient prognosis. In the long term, these characteristics may aid in the development of strategies to combat therapeutic resistance.
Published: 2024
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50. Calculating power for multilevel implementation trials in mental health: Meaningful effect sizes, intraclass correlation coefficients, and proportions of variance explained by covariates

Author: Nathaniel J. Williams, Nicholas C. Cardamone, Rinad S. Beidas, and Steven C. Marcus
Subjects: Mental healing, RZ400-408, Psychiatry, RC435-571
Abstract: Background Despite the ubiquity of multilevel sampling, design, and analysis in mental health implementation trials, few resources are available that provide reference values of design parameters (e.g., effect size, intraclass correlation coefficient [ICC], and proportion of variance explained by covariates [covariate R 2 ]) needed to accurately determine sample size. The aim of this study was to provide empirical reference values for these parameters by aggregating data on implementation and clinical outcomes from multilevel implementation trials, including cluster randomized trials and individually randomized repeated measures trials, in mental health. The compendium of design parameters presented here represents plausible values that implementation scientists can use to guide sample size calculations for future trials. Method We searched NIH RePORTER for all federally funded, multilevel implementation trials addressing mental health populations and settings from 2010 to 2020. For all continuous and binary implementation and clinical outcomes included in eligible trials, we generated values of effect size, ICC, and covariate R 2 at each level via secondary analysis of trial data or via extraction of estimates from analyses in published research reports. Effect sizes were calculated as Cohen d ; ICCs were generated via one-way random effects ANOVAs; covariate R 2 estimates were calculated using the reduction in variance approach. Results Seventeen trials were eligible, reporting on 53 implementation and clinical outcomes and 81 contrasts between implementation conditions. Tables of effect size, ICC, and covariate R 2 are provided to guide implementation researchers in power analyses for designing multilevel implementation trials in mental health settings, including two- and three-level cluster randomized designs and unit-randomized repeated-measures designs. Conclusions Researchers can use the empirical reference values reported in this study to develop meaningful sample size determinations for multilevel implementation trials in mental health. Discussion focuses on the application of the reference values reported in this study.
Published: 2024
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