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439 results on '"Iyer, Subramania"'

2. Improving accuracy in nodal staging of oral cancer: Proposal of a new system

Author

Subramaniam, Narayana, Heller, Gillian, Clark, Jonathan Robert, Gupta, Ruta, Goldstein, David, de Almeida, John R., Hosni, Ali, Balasubramanian, Deepak, Thankappan, Krishnakumar, Iyer, Subramania, Batstone, Martin, Iyer, N. Gopal, Smee, Robert I., Chandrasekhar, Naveen Hedne, Pillai, Vijay, Shetty, Vivek, Rangappa, Vidyabhushan, Veness, Michael, and Low, Tsu-Hui (Hubert)

Published
2024
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11. Oncological outcomes of compartmental surgery and wide local excision in oral tongue and floor of the mouth cancer

Author

Missale, Francesco, Marchi, Filippo, Iandelli, Andrea, Subramaniam, Narayana, Dokhe, Yogesh, Sampieri, Claudio, Mattavelli, Davide, Bresciani, Lorenzo, Carobbio, Andrea Luigi Camillo, Grammatica, Alberto, Thankappan, Krishnakumar, Iyer, Subramania, Fontanella, Walter, Giannini, Lorenzo, Peretti, Giorgio, Parrinello, Giampiero, Balasubramanian, Deepak, and Piazza, Cesare

Published
2022
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20. Geographical heterogeneity in the American Joint committee on Cancer oral cancer staging and prognostic implications

Author

Subramaniam, Narayana, Clark, Jonathan Robert, Goldstein, David, de Almeida, John, Abdalaty, Ali Hosni Ali, Balasubramanian, Deepak, Thankappan, Krishnakumar, Iyer, Subramania, Batstone, Martin, Iyer, N. Gopal, Smee, Robert I, Chandrasekhar, Naveen Hedne, Pillai, Vijay, Shetty, Vivek, Rangappa, Vidyabhushan, Veness, Michael, and Low, Tsu-Hui Hubert

Published
2021
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39. Contrasting clinical outcomes and socio‐economic impact of young versus elderly‐onset oral squamous cell carcinoma, a novel health economic analysis.

Author

Singh, Manraj, Thankappan, Krishnakumar, Balasubramanian, Deepak, Pillai, Vijay, Shetty, Vivek, Rangappa, Vidyabhushan, Chandrasekhar, Naveen Hedne, Kekatpure, Vikram, Kuriakose, Moni Abraham, Krishnamurthy, Arvind, Mitra, Arun, Pattatheyil, Arun, Jain, Prateek, Iyer, Subramania, Iyer, N. Gopalakrishna, and Subramaniam, Narayana

Subjects
SQUAMOUS cell carcinoma, EARLY death, TREATMENT effectiveness, ECONOMIC impact, OLDER patients
Abstract

Objectives: The incidence of young‐onset oral squamous cell carcinoma (OSCC) is growing, even among non‐smokers/drinkers. The effects of adverse histopathological features on long‐term oncologic outcomes between the young and old are controversial and confounded by significant heterogeneity. Few studies have evaluated the socio‐economic impact of premature mortality from OSCC. Our study seeks to quantify these differences and their economic impact on society. Materials and Methods: Four hundred and seventy‐eight young (<45 years) and 1660 old patients (≥45 years) with OSCC were studied. Logistic regression determined predictors of recurrence and death. Survival analysis was calculated via the Kaplan–Meier method. A separate health economic analysis was conducted for India and Singapore. Years of Potential Productive Life Lost (YPPLL) were estimated with the Human Capital Approach, and premature mortality cost was derived using population‐level data. Results: Adverse histopathological features were seen more frequently in young OSCC: PNI (42.9% vs. 35%, p = 0.002), LVI (22.4% vs. 17.3%, p = 0.013) and ENE (36% vs. 24.5%, p < 0.001). Although 5‐year OS/DSS were similar, the young cohort had received more intensive adjuvant therapy (CCRT 26.9% vs. 16.6%, p < 0.001). Among Singaporean males, the premature mortality cost per death was US $396,528, and per YPPLL was US $45,486. This was US $397,402 and US $38,458 for females. Among Indian males, the premature mortality cost per death was US $30,641, and per YPPLL was US $595. This was US $ 21,038 and US $305 for females. Conclusion: Young‐onset OSCC is an aggressive disease, mitigated by the ability to receive intensive adjuvant treatment. From our loss of productivity analysis, the socio‐economic costs from premature mortality are substantial. Early cancer screening and educational outreach campaigns should be tailored to this cohort. Alongside, more funding should be diverted to genetic research, developing novel biomarkers and improving the efficacy of adjuvant treatment in OSCC. [ABSTRACT FROM AUTHOR]

Published
2024
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44. Clinical Significance of Alloantibodies in Hand Transplantation: A Multicenter Study

Author

Berglund, Erik, Andersen Ljungdahl, Mette, Bogdanović, Darko, Berglund, David, Wadström, Jonas, Kowalski, Jan, Brandacher, Gerald, Kamińska, Dorota, Kaufman, Christina L., Talbot, Simon G., Azari, Kodi, Landin, Luis, Höhnke, Christoph, Dwyer, Karen M., Cavadas, Pedro C., Thione, Alessandro, Clarke, Brendan, Kay, Simon, Wilks, Dan, Iyer, Subramania, Iglesias, Martin, Özkan, Ömer, Özkan, Özlenen, Krapf, Johanna, Weissenbacher, Annemarie, Petruzzo, Palmina, and Schneeberger, Stefan

Published
2019
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45. Primary Tumor Staging for Oral Cancer and a Proposed Modification Incorporating Perineural Invasion: An International Multicenter Study.

Author

Na'ara, Shorook, Subramaniam, Narayana, Deganello, Alberto, Shinnawi, Shadi, Billan, Salem, Mattavelli, Davide, Ferrari, Marco, Balasubramanian, Deepak, Thankappan, Krishnakumar, Iyer, Subramania, and Gil, Ziv

Subjects
ORAL cancer, TUMOR classification, SQUAMOUS cell carcinoma, INSPECTION & review, PROGRESSION-free survival, MULTIVARIATE analysis
Abstract

The objective of this study is to determine if the incorporation of perineural invasion (PNI) into the T‐classification would improve the prognostic performance of TNM‐8. An international, multicenter study of 1049 patients with oral cavity squamous cell carcinoma that were treated from 1994 to 2018 is performed. Various classification models are developed within each T‐category and evaluated using the Harrel‐concordance index (C‐index), Akaike‐information criterion (AIC), and visual inspection. Stratification into distinct prognostic categories, with internal validation, is performed using bootstrapping analysis (SPSS and R‐software). Through multivariate analysis, PNI is significantly associated with disease‐specific survival (p < 0.001). PNI integration into the staging system results in a significantly improved model compared with the current T category alone (lower AIC, p < 0.001). The PNI‐integrated model is superior in predicting differential outcomes between T3 and T4 patients. A new model for T‐classification of oral cavity squamous cell carcinoma is proposed, which is based on incorporating PNI into the staging system. These data can be used for future evaluations of the TNM staging system. [ABSTRACT FROM AUTHOR]

Published
2023
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47. Challenges to effective cancer control in China, India, and Russia

Author

Goss, Paul E, Strasser-Weippl, Kathrin, Lee-Bychkovsky, Brittany L, Fan, Lei, Li, Junjie, Chavarri-Guerra, Yanin, Liedke, Pedro E R, Pramesh, C S, Badovinac-Crnjevic, Tanja, Sheikine, Yuri, Chen, Zhu, Qiao, You-lin, Shao, Zhiming, Wu, Yi-Long, Fan, Daiming, Chow, Louis W C, Wang, Jun, Zhang, Qiong, Yu, Shiying, Shen, Gordon, He, Jie, Purushotham, Arnie, Sullivan, Richard, Badwe, Rajendra, Banavali, Shripad D, Nair, Reena, Kumar, Lalit, Parikh, Purvish, Subramanian, Somasundarum, Chaturvedi, Pankaj, Iyer, Subramania, Shastri, Surendra Srinivas, Digumarti, Raghunadhrao, Soto-Perez-de-Celis, Enrique, Adilbay, Dauren, Semiglazov, Vladimir, Orlov, Sergey, Kaidarova, Dilyara, Tsimafeyeu, Ilya, Tatishchev, Sergei, Danishevskiy, Kirill D, Hurlbert, Marc, Vail, Caroline, St Louis, Jessica, and Chan, Arlene

Published
2014
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48. Injectable Pectin–Alginate Hydrogels for Improving Vascularization and Adipogenesis of Human Fat Graft.

Author

Janarthanan, Ramu, Jayakumar, Rangasamy, and Iyer, Subramania

Subjects
ADIPOGENESIS, FAT, HYDROGELS, PLATELET-rich plasma, AUTOTRANSPLANTATION, PECTINS
Abstract

Autologous fat grafting (AFG) is the most prevailing tool for soft tissue regeneration in clinics, although efficiency is limited to unpredictable volume resorption due to poor vascularization and eventual necrosis. This study sought to improve the AFG efficiency using a hydrogel as a carrier for human fat graft (F) with and without platelet-rich plasma (PRP). PRP is clinically well known for the local release of several endogenous growth factors and has been in clinical use already. A human-fat-graft-encapsulated pectin–alginate hydrogel (FG) was developed and characterized. PRP was added to F to develop a human fat graft with PRP (FP). FP was admixed with a pectin–alginate hydrogel to develop FGP. FG and FGP showed the smooth injectable, elastic, and shear-thinning properties. FG and FGP groups showed enhanced cell viability and proliferation compared to the control F in vitro. We also investigated the in vivo angiogenesis and neo-adipogenesis ability of F, FG, FGP, and FP in nude mice after subcutaneous injection. After 2 and 4 weeks, an MRI of the mice was conducted, followed by graft explantation. The explanted grafts were also assessed histologically and with immunohistochemistry (IHC) studies. MRI and histology results revealed better vascularity of the FG and FGP system compared to fat graft alone. Further, the IHC studies, CD 31, and perilipin staining also revealed better vasculature and adipogenesis of FG and FGP systems. These results indicate the enhanced angiogenesis and adipogenesis of FG and FGP. Thus, developed pectin–alginate hydrogel-based fat graft systems FG and FGP replenish the native microenvironment by mediating angiogenesis and adipogenesis, thereby maximizing the clinical outcomes of autologous fat grafting. [ABSTRACT FROM AUTHOR]

Published
2023
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49. Premetastatic Niche: A Novel Area for Research in Metastasis with a Potential as Therapeutic Targeting in Oral Cancer.

Author

Geetha, Rajalakshmi, Janardhanan, Mahija, Thankappan, Krishna Kumar, and Iyer, Subramania

Subjects
ORAL cancer, PROGNOSIS, METASTASIS, LYMPHATIC metastasis, MEDICAL research
Abstract

Premetastatic niche (PMN) concept, introduced by David Lyden and colleagues, is an area that can support cancer cells to nurture in it, but the area itself being bereft of cancerous cells. It provides a microenvironment that is congenial for tumor invasion, endurance, and or proliferation of malignant cells to develop into metastasis. These are noncancerous variations in a tumor-free organ and are the most primitive indications of metastasis. These may have a potential to serve as a diagnostic aid, prognostic biomarkers, and therapeutic target. Nevertheless, there is still no clear elucidation on diverse trails of tumor metastasis via lymphatic or hematogenous route, especially in relationship with the PMN. In this review, contemporary knowledge associated with nodal premetastatic niche formation with forthcoming directions on translational and clinical research is deliberated. [ABSTRACT FROM AUTHOR]

Published
2023
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50. VCA in the Era of the COVID-19 Pandemic

Author

Petruzzo, Palmina, Kanitakis, Jean, Sardu, Claudia, Bassiri Gharb, Bahar, Morelon, Emmanuel, Amer, Hatem, Barret, Juan, Burt, James, Brandacher, Gerald, Gomez, Tomas, Kay, Simon, Kaminska, Dorotha, Kaufman, Christina L, Kumar, Dinesh S, Iglesias, Martin, Iyer, Subramania, Landin, Luis, Lanzetta, Marco, Lassus, Patrick, Levin, Scott, Papay, Francis, Pomahac, Bohdan, Sassu, Paolo, Satbhai, Nilesh G, Talbot, Simon, VCA-COVID Survey Group, HUS Musculoskeletal and Plastic Surgery, Clinicum, and Plastiikkakirurgian yksikkö

Subjects
Herpesvirus 4, Human, Transplantation, ORGAN-TRANSPLANTATION, REGISTRY, COVID-19, Humans, 3126 Surgery, anesthesiology, intensive care, radiology, Antigens, Viral, Pandemics
Abstract

Since its onset in the beginning of 2020, the coronavirus disease 2019 (COVID-19) pandemic has impacted the transplantation community broadly. Indeed, the number of transplantations decreased dramatically and transplantations were temporarily shut down in many localities.1,2 The dramatic impact of the COVID-19 pandemic on solid organ transplant (SOT) recipients began to emerge with reports initially from China, Spain, and Italy. The prevalence of COVID-19 in SOT during the first pandemic wave varied geographically, but despite several reports, the effective incidence of the COVID-19 in SOT recipients remains unclear.2-5 Most relevant, solid organ transplantation (heart, liver, and kidney) rates declined, exposing candidates to an increased rate of waitlist mortality.Vascularized composite allotransplantation (VCA) is an emerging field of transplantation; approximately 200 to 300 procedures have been performed thus far6,7 since the first hand transplantation in 1998. VCA (including upper and lower extremity, face, larynx, uterus, penis and abdominal wall transplants) is usually contemplated as life-enhancing rather than life-saving procedures but nevertheless requires lifelong immunosuppression. Although, VCA recipients are exposed to the same risks as SOT recipients, no relevant data have been so far published on the impact of COVID-19 on VCA.

Published
2022

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