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398 results on '"Iwashita, Akinori"'

3. A review on the current status and definitions of activity indices in inflammatory bowel disease: how to use indices for precise evaluation

Author

Kishi, Masahiro, Hirai, Fumihito, Takatsu, Noritaka, Hisabe, Takashi, Takada, Yasumichi, Beppu, Tsuyoshi, Takeuchi, Ken, Naganuma, Makoto, Ohtsuka, Kazuo, Watanabe, Kenji, Matsumoto, Takayuki, Esaki, Motohiro, Koganei, Kazutaka, Sugita, Akira, Hata, Keisuke, Futami, Kitarou, Ajioka, Yoichi, Tanabe, Hiroshi, Iwashita, Akinori, Shimizu, Hirotaka, Arai, Katsuhiro, Suzuki, Yasuo, and Hisamatsu, Tadakazu

Published
2022
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7. Correction to: Crohn’s disease-specific mortality: a 30-year cohort study at a tertiary referral center in Japan

Author

Yasukawa, Shigeyoshi, Matsui, Toshiyuki, Yano, Yutaka, Sato, Yuho, Takada, Yasumichi, Kishi, Masahiro, Ono, Yoichiro, Takatsu, Noritaka, Nagahama, Takashi, Hisabe, Takashi, Hirai, Fumihito, Yao, Kenshi, Ueki, Toshiharu, Higashi, Daijiro, Futami, Kitaro, Sou, Suketo, Sakurai, Toshihiro, Yao, Tsuneyoshi, Tanabe, Hiroshi, Iwashita, Akinori, and Washio, Masakazu

Published
2021
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8. Crohn’s disease-specific mortality: a 30-year cohort study at a tertiary referral center in Japan

Author

Yasukawa, Shigeyoshi, Matsui, Toshiyuki, Yano, Yutaka, Sato, Yuho, Takada, Yasumichi, Kishi, Masahiro, Ono, Yoichiro, Takatsu, Noritaka, Nagahama, Takashi, Hisabe, Takashi, Hirai, Fumihito, Yao, Kenshi, Ueki, Toshiharu, Higashi, Daijiro, Futami, Kitaro, Sou, Suketo, Sakurai, Toshihiro, Yao, Tsuneyoshi, Tanabe, Hiroshi, Iwashita, Akinori, and Washio, Masakazu

Published
2019
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10. Esophageal xanthoma: presence of M2 macrophages suggests association with late inflammatory and reparative processes

Author

Uehara Karina, Iwashita Hidehiko, Tanabe Yasuka, Kurima Kiyoto, Oshiro Mariko, Kina Shinichiro, Ota Atsuko, Iwashita Akinori, and Kinjo Takao

Subjects
esophagus, abnormalities, diagnostic imaging, pathology, Medicine
Abstract

Esophageal xanthoma is a rare lesion which is an asymptomatic small yellowish polyp, and most of the reported cases were solitary lesion. Histologically, aggregations of foam cells are found under the papillary hypertrophic squamous epithelium and the foam cells express CD68. The etiology of esophageal xanthoma is unknown. The focal irritation of the esophageal mucosa and infiltrated inflammatory cells are presumed to contribute to its pathogenesis. Although the pathogenesis may be associated with inflammation, the type and nature of the macrophages remain unclear. Here we report a 46-year-old male with esophageal xanthoma, which was incidentally found by endoscopy. Histologically, acute inflammation was not noted, and immunohistochemistry revealed that the foam cells seen in this case of esophageal xanthoma expressed increased levels of M2 macrophage markers. These findings suggest that esophageal xanthoma is associated with late inflammatory and reparative processes long after the initial inflammation of esophageal squamous epithelium.

Published
2017
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11. A three-tier classification system based on the depth of submucosal invasion and budding/sprouting can improve the treatment strategy for T1 colorectal cancer: a retrospective multicenter study

Author

Kawachi, Hiroshi, Eishi, Yoshinobu, Ueno, Hideki, Nemoto, Tetsuo, Fujimori, Takahiro, Iwashita, Akinori, Ajioka, Yoichi, Ochiai, Atsushi, Ishiguro, Shingo, Shimoda, Tadakazu, Mochizuki, Hidetaka, Kato, Yo, Watanabe, Hidenobu, Koike, Morio, and Sugihara, Kenichi

Published
2015
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14. White Opaque Substance, a New Optical Marker on Magnifying Endoscopy: Usefulness in Diagnosing Colorectal Epithelial Neoplasms

Author

Yamasaki, Kazutomo, Hisabe, Takashi, Yao, Kenshi, Ishihara, Hiroshi, Imamura, Kentaro, Yasaka, Tatsuhisa, Tanabe, Hiroshi, Iwashita, Akinori, and Ueki, Toshiharu

Subjects
medicine.medical_specialty, white opaque substance, Adenoma, Colorectal cancer, magnifying endoscopy, Medicine (miscellaneous), narrow band imaging, Colorectal adenoma, RC799-869, medicine, Carcinoma, White substance, Radiology, Nuclear Medicine and imaging, Endoscopic resection, Internal medicine, business.industry, Magnifying endoscopy, Gastroenterology, colorectal neoplasms, Diseases of the digestive system. Gastroenterology, medicine.disease, RC31-1245, Original Article, Radiology, Differential diagnosis, business
Abstract

Background/Aims: A white substance that is opaque to endoscopic light is sometimes observed in the epithelium during narrowband imaging with magnifying endoscopy of gastric or colorectal epithelial neoplasms. This prospective observational study aimed to determine whether the morphology of the white opaque substance (WOS) allows differential diagnosis between colorectal adenoma and carcinoma.Methods: A consecutive series of patients with colorectal adenomas or early carcinomas who underwent endoscopic resection or surgical excision were studied. The morphology of the WOS was determined based on endoscopic images before the histopathological diagnosis was performed. The primary outcome was the diagnostic performance of an irregular WOS as a marker of colorectal carcinoma.Results: The study analyzed 125 lesions. A total of 33 lesions showed an irregular WOS, and 92 lesions showed a regular WOS. Among the 33 lesions found to show an irregular WOS, 30 were carcinomas. Among the 92 lesions showing a regular WOS, 79 were adenomas. With irregular WOS as a marker of carcinoma, the diagnostic accuracy was 87%, sensitivity was 91%, and specificity was 86%.Conclusions: This study demonstrated the potential usefulness of the morphology of the WOS as a marker for the differential diagnosis between adenoma and carcinoma in cases of colorectal epithelial neoplasms.

Published
2021

21. Magnifying endoscopy with narrow‐band imaging for diagnosis of subtype of gastric intestinal metaplasia.

Author

Kanemitsu, Takao, Uedo, Noriya, Ono, Takahiro, Nimura, Satoshi, Hasegawa, Rino, Imamura, Kentaro, Ohtsu, Kensei, Ono, Yoichiro, Miyaoka, Masaki, Ueki, Toshiharu, Tanabe, Hiroshi, Ohta, Atsuko, Iwashita, Akinori, and Yao, Kenshi

Subjects
METAPLASIA, ENDOSCOPY, ENDOSCOPIC surgery, INTESTINES, IMMUNOSTAINING
Abstract

Background and Aim: Patients with incomplete gastric intestinal metaplasia (GIM) have a higher risk of gastric cancer (GC) than those with complete GIM. We aimed to clarify whether micromucosal patterns of GIM in magnifying endoscopy with narrow‐band imaging (M‐NBI) were useful for diagnosis of incomplete GIM. Methods: We enrolled patients with a history of endoscopic resection of GC or detailed inspection for suspicious or definite GC. The antrum greater curvature and corpus lesser curvature were regions of interest. Areas with endoscopic findings of light blue crest and/or white opaque substance (WOS) were defined as endoscopic GIM, and subsequent M‐NBI was applied. Micromucosal patterns were classified into Foveola and Groove types, and targeted biopsies were performed on GIM with each pattern. GIM was classified into complete and incomplete types using mucin (MUC)2, MUC5AC, MUC6, and CD10 immunohistochemical staining. The primary endpoint was the association between micromucosal pattern and histological subtype. The secondary endpoint was endoscopic findings associated with incomplete GIM. Results: We analyzed 98 patients with 156 GIMs. Univariate analysis (odds ratio [OR] 3.4, P = 0.004), but not multivariate analysis (OR 0.87, P = 0.822), demonstrated a significant association between micromucosal pattern and subtype. The antrum (OR 3.7, P = 0.006) and WOS (OR 43, P = 0.002) were independent predictors for incomplete GIM. The WOS had 69% sensitivity and 93% specificity. Conclusions: The M‐NBI micromucosal pattern is not useful for diagnosis of GIM subtype. WOS is a promising endoscopic indicator for diagnosis of incomplete GIM. (UMIN‐CTR000041119). [ABSTRACT FROM AUTHOR]

Published
2023
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27. Gross Pathology of Superficial Esophageal Carcinoma with Special Reference to Depth of Tumor Invasion : An Analysis of 405 Lesions from 363 Cases, 2000-2016

Author

Nimura, Satoshi, Tanabe, Hiroshi, Iwashita, Akinori, Ota, Atsuko, Takaki, Yasuhiro, Nagahama, Takashi, Ishibashi, Hideki, Watanabe, Takashi, Shiwaku, Hironari, Yamashita, Kanefumi, Yamana, Ipei, Yoshimura, Fumihiro, Maki, Kenji, Maekawa, Takafumi, Takeno, Shinsuke, Shiraishi, Takeshi, Nabeshima, Kazuki, and Takeshita, Morishige

Subjects
Superficial esophageal carcinoma, Dome-like protrusion, Submucosal invasive carcinoma, Depth of tumor invasion, Gross pathology, Ulceration, Intramucosal carcinoma
Published
2018

48. CLINICAL AND ENDOSCOPIC FEATURES OF AMYLOIDOSIS SECONDARY TO CROHNʼS DISEASE: DIAGNOSTIC VALUE OF DUODENAL OBSERVATION AND BIOPSY

Author

Miyaoka, Masaki, Matsui, Toshiyuki, Hisabe, Takashi, Yano, Yutaka, Hirai, Fumihito, Takaki, Yasuhiro, Nagahama, Takashi, Beppu, Takahiro, Murakami, Yuji, Maki, Shinichiro, Takatsu, Noritaka, Ninomiya, Kazeo, Ono, Yoichiro, Kanemitsu, Takao, Nishimata, Nobuaki, Tanabe, Hiroshi, Ikeda, Keisuke, Haraoka, Seiji, and Iwashita, Akinori

Published
2011
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