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269 results on '"Israel, Mark A."'

12. Cardiovascular and renal oxidative stress-mediated toxicities associated with bisphenol-A exposures are mitigated by Curcuma longa in rats.

Author

Ajibade, Temitayo Olabisi, Esan, Oluwaseun Olanrewaju, Osawere, Israel Mark, Adetona, Moses Olusola, Aina, Oluwasanmi Olayinka, Azeez, Odunayo Ibraheem, Obisesan, Ayobami Deborah, Oyagbemi, Ademola Adetokunbo, Ola-Davies, Olufunke Eunice, Omobowale, Temidayo Olutayo, Saba, Adebowale Benard, Adedapo, Adeolu Alex, Yakubu, Momoh Audu, and Oguntibeju, Oluwafemi Omoniyi

Subjects
BISPHENOL A, POISONS, OXIDANT status, RATS, TURMERIC, OXIDATIVE stress, BLOOD pressure, NATURAL products, GENETIC toxicology
Abstract

Objective: Curcuma longa Rhizome (CLR), due to its potent antioxidant phytochemical constituents, was investigated for its effects on bisphenol A (BPA)-induced cardiovascular and renal damage. Materials and Methods: Sixty rats were randomly selected, and grouped as control, BPA (100 mg/kg), BPA and CLR 100 mg/kg, BPA and CLR 200 mg/kg, CLR 100 mg/kg, and CLR 200 mg/kg for 21 days. Oxidative stress indices, antioxidant status, blood pressure parameters, genotoxicity, and immunohistochemistry were determined. Results: Rats exposed to the toxic effects of BPA had heightened blood pressure, lowered frequency of micronucleated polychromatic erythrocytes, and decreased activities of antioxidant enzymes compared with rats treated with CLR. Moreover, administration of CLR significantly (p<0.05) lowered malondialdehyde content and reduced the serum myeloperoxidase activity. Immunohistochemical evaluation revealed significantly (p<0.05) increased expressions of cardiac troponin and Caspase 3 in the BPA group compared with the CLR-treated groups. Conclusion: C. longa ameliorated cardiotoxic and nephrotoxic actions of bisphenol-A via mitigation of oxidative stress, hypertension, and genotoxicity. [ABSTRACT FROM AUTHOR]

Published
2024
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26. "I won't be able to speak for three days after": Ethical and practical considerations in qualitative research involving people with a laryngectomy.

Author

Bickford, Jane, Hersh, Deborah, and Israel, Mark

Subjects
LARYNGECTOMY, ACQUISITION of data, RESEARCH ethics, QUALITATIVE research, CONCEPTUAL structures, QUALITY of life, DATA analysis, RESPECT, DIFFUSION of innovations
Abstract

Purpose: A laryngectomy impacts communication, swallowing and breathing. It is disfiguring and can disrupt quality of life, one's sense of identity, and relationships. It can increase dependence on others, trigger social stigma, avoidant coping and suicidal risk. Qualitative research has the potential to enable greater understanding of these consequences. However, almost nothing has been written about the specific ethical issues that can arise when carrying out research with people with laryngectomy (PWL). This paper builds on the experiences of the authors in the field and seeks to examine and explain these research ethics considerations and how they impact research design, data collection, data analysis and dissemination. Method: Using a framework based on the values underpinning the Australian National Statement on Ethical Conduct in Human Research, respect, merit and integrity, justice and beneficence, we have highlighted key issues relevant to this particular population. Main contribution: Different practical approaches are provided to address the ethical concerns that arise when conducting research with PWL. These include access to participants and ensuring diverse representation; balancing harm and benefit; achieving accurate interpretation, analysis and representation of the data generated through the research; research as a partnership that is respectful, empowering and fosters collaboration. Conclusion: This paper breaks new ground in discussing the ethical considerations and practical challenges relevant to researching the experiences of PWL. [ABSTRACT FROM AUTHOR]

Published
2023
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27. ARE YOU PUSHING TOO HARD? LOWER NEGOTIATED INPUT PRICES AS A MERGER EFFICIENCY

Author

Israel, Mark A., Stemwedel, Thomas A., and Tse, Ka Hei

Subjects
Industrial efficiency -- Research, Prices -- Mergers, acquisitions and divestments -- Research, Health care industry -- Mergers, acquisitions and divestments, Acquisitions and mergers -- Prices and rates -- Research, Health care industry, Company acquisition/merger, Company pricing policy, Law
Abstract

Should lower input prices as a merger outcome be considered a competitive harm or benefit? As a matter of economics, the answer depends on the specific facts: Reduced input prices [...]

Published
2018

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