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Your search keyword '"Innocenti, O"' showing total 2 results
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2 results on '"Innocenti, O"'

1. Natural fluorescence imaging of leukemic cells for studying uptake and retention of anthracyclines.

Author

Monici M, Fusi F, Mazzinghi P, Degli Innocenti o Nocentini A, Landini I, Banchelli I, Bartolozzi B, Santini V, and Bernabei PA

Subjects
Biological Transport, HL-60 Cells, Humans, Microscopy, Fluorescence instrumentation, Spectrometry, Fluorescence instrumentation, Antibiotics, Antineoplastic pharmacokinetics, Leukemia metabolism, Leukemia pathology, Microscopy, Fluorescence methods, Spectrometry, Fluorescence methods
Published
1999
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2. Activity of vinorelbine on B-chronic lymphocytic leukemia cells in vitro.

Author

Bernabei PA, Landini I, Bartolozzi B, Banchelli I, Degli Innocenti o Nocentini A, Santini V, and Ematologia UO

Subjects
Aged, B-Lymphocytes drug effects, Drug Screening Assays, Antitumor, Female, Humans, Male, Middle Aged, Tumor Cells, Cultured, Vinblastine toxicity, Vinorelbine, Antineoplastic Agents, Phytogenic toxicity, B-Lymphocytes pathology, Leukemia, Lymphocytic, Chronic, B-Cell pathology, Vinblastine analogs & derivatives
Abstract

Vinorelbine (VNR) is a new semi-synthetic Vinca rosea alkaloid that has been employed both in combination and as a single agent, showing a significant antitumour activity. Since little is known about VNR in human leukemia, we studied the in vitro cytotoxic effect of VNR on peripheral blood lymphocytes from 18 patients affected by B-chronic lymphocytic leukemia (CLL), employing the INT assay. VNR inhibited fresh B-CLL cells from 15/18 patients in primary cultures, the ID50 doses ranging from 4 ng/ml to 83 micrograms/ml. These data strongly suggest that VNR could be effective in the treatment of B-CLL.

Published
1999
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