Search

Your search keyword '"Illes, Peter"' showing total 548 results
Start Over Author "Illes, Peter" Language english
548 results on '"Illes, Peter"'

9. Separating the Wheat From the Chaff in Asthma and Bronchiectasis: The Saga Trajectory of a Patient With Adult-Onset RAG1 Deficiency

Author

Chitty Lopez, Maria, Yilmaz, Melis, Diaz-Cabrera, Natalie M., Saco, Tara, Ishmael, Leah, Sotoudeh, Shannon, Bindernagel, Constance, Ujhazi, Boglarka, Gordon, Sumai, Potts, David Evan, Danziger, Roger, Bosticardo, Marita, Kenney, Heather, Illes, Peter, Lee, Sena, Harris, Megan, Cuellar-Rodriguez, Jennifer, Patel, Kapil N., Csomos, Krisztian, Dimitrova, Dimana, Kanakry, Jennifer A., Notarangelo, Luigi D., and Walter, Jolan E.

Published
2023
Full Text
View/download PDF

15. Deciphering structural bases of intestinal and hepatic selectivity in targeting pregnane X receptor with indole-based microbial mimics

Author

Li, Hao, Illés, Peter, Karunaratne, Chamini V., Nordstrøm, Lars Ulrik, Luo, Xiaoping, Yang, Annie, Qiu, Yunping, Kurland, Irwin J., Lukin, Dana J., Chen, Weijie, Jiskrová, Eva, Krasulová, Kristýna, Pečinková, Petra, DesMarais, Vera M., Liu, Qiang, Albanese, Joseph M., Akki, Ashwin, Longo, Michael, Coffin, Breyen, Dou, Wei, Mani, Sridhar, and Dvořák, Zdeněk

Published
2021
Full Text
View/download PDF

18. Astrocyte activation in hindlimb somatosensory cortex contributes to electroacupuncture analgesia in acid-induced pain.

Author

Qing Ye, Jie Li, Wen-Jing Ren, Ying Zhang, Tao Wang, Rubini, Patrizia, Hai-Yan Yin, Illes, Peter, and Yong Tang

Subjects
SOMATOSENSORY cortex, ELECTROACUPUNCTURE, HINDLIMB, ANALGESIA, PAIN management, EXPERIMENTAL arthritis
Abstract

Background: Several studies have confirmed the direct relationship between extracellular acidification and the occurrence of pain. As an effective pain management approach, the mechanism of electroacupuncture (EA) treatment of acidification-induced pain is not fully understood. The purpose of this study was to assess the analgesic effect of EA in this type of pain and to explore the underlying mechanism(s). Methods: We used plantar injection of the acidified phosphate-buffered saline (PBS; pH 6.0) to trigger thermal hyperalgesia in male Sprague--Dawley (SD) rats aged 6-8 weeks. The value of thermal withdrawal latency (TWL) was quantified after applying EA stimulation to the ST36 acupoint and/or chemogenetic control of astrocytes in the hindlimb somatosensory cortex. Results: Both EA and chemogenetic astrocyte activation suppressed the acidinduced thermal hyperalgesia in the rat paw, whereas inhibition of astrocyte activation did not influence the hyperalgesia. At the same time, EA-induced analgesia was blocked by chemogenetic inhibition of astrocytes. Conclusion: The present results suggest that EA-activated astrocytes in the hindlimb somatosensory cortex exert an analgesic effect on acid-induced pain, although these astrocytes might only moderately regulate acid-induced pain in the absence of EA. Our results imply a novel mode of action of astrocytes involved in EA analgesia. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

31. Rewiring the altered tryptophan metabolism as a novel therapeutic strategy in inflammatory bowel diseases.

Author

Michaudel, Chloé, Danne, Camille, Agus, Allison, Magniez, Aurélie, Aucouturier, Anne, Spatz, Madeleine, Lefevre, Antoine, Kirchgesner, Julien, Rolhion, Nathalie, Yazhou Wang, Lavelle, Aonghus, Galbert, Chloé, Da Costa, Gregory, Poirier, Maxime, Lapière, Alexia, Planchais, Julien, Nádvorník, Petr, Illes, Peter, Oeuvray, Cyriane, and Creusot, Laura

Subjects
INFLAMMATORY bowel diseases, BUTYRATES, TRYPTOPHAN, METABOLISM, IRRITABLE colon, SEROTONIN syndrome, CYTOLOGY, LIQUID chromatography-mass spectrometry
Published
2023
Full Text
View/download PDF

36. Functionally impaired antibody response to BNT162b2 booster vaccination in CVID IgG responders.

Author

Sauerwein, Kai M.T., Geier, Christoph B., Stemberger, Roman F., Rossmanith, Raphael, Akyaman, Hüseyin, Illes, Peter, Fischer, Michael B., Eibl, Martha M., Walter, Jolan E., and Wolf, Hermann M.

Abstract

Although previous studies described the production of IgG antibodies in a subgroup of patients with common variable immunodeficiency (CVID) following messenger RNA vaccinations with BNT162b2 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (CVID responders), the functionality of these antibodies in terms of avidity as measured by the dissociation rate constant (k dis) and the antibody response to booster immunization has not been studied. We sought to analyze in CVID responders and healthy individuals, the avidity of anti–SARS-CoV-2 serum antibodies and their neutralization capacity as measured by surrogate virus–neutralizing antibodies in addition to IgG-, IgM-, and IgA-antibody levels and the response of circulating (peripheral blood) follicular T-helper cells after a third vaccination with BNT162b2 SARS-CoV-2 messenger RNA vaccine. Binding IgG, IgA, and IgM serum levels were analyzed by ELISA in patients with CVID responding to the primary vaccination (CVID responders, n = 10) and healthy controls (n = 41). The binding avidity of anti–spike antibodies was investigated using biolayer interferometry in combination with biotin-labeled receptor-binding-domain of SARS-CoV-2 spike protein and streptavidin-labeled sensors. Antigen-specific recall T-cell responses were assessed by measuring activation-induced markers by flow cytometry. After the third vaccination with BNT162b2, IgG-, IgM-, and IgA-antibody levels, surrogate virus–neutralizing antibody levels, and antibody avidity were lower in CVID responders than in healthy controls. In contrast, anti–SARS-CoV-2 spike protein avidity was comparable in CVID responders and healthy individuals following primary vaccination. Follicular T-helper cell response to booster vaccination in CVID responders was significantly reduced when compared with that in healthy individuals. Impaired affinity maturation during booster response provides new insight into CVID pathophysiology. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

41. Association of the ADORA2A receptor and CD73 polymorphisms with epilepsy.

Author

Nan-Rui Shi, Qi Wang, Jie Liu, Ji-Zhou Zhang, Bin-Lu Deng, Xiu-Min Hu, Jie Yang, Xin Wang, Xiang Chen, Yan-Qin Zuo, Ting-Ting Liu, Jia-Ling Zheng, Xin Yang, Illes, Peter, and Yong Tang

Subjects
EPILEPSY, SINGLE nucleotide polymorphisms, GENETIC polymorphisms, GENETIC variation, PEOPLE with epilepsy, PURINERGIC receptors
Abstract

Single-nucleotide polymorphisms are connected with the risk of epilepsy on occurrence, progress, and the individual response to drugs. Progress in genomic technology is exposing the complex genetic architecture of epilepsy. Compelling evidence has demonstrated that purines and adenosine are key mediators in the epileptic process. Our previous study found the interconnection of P2Y12 receptor single-nucleotide polymorphisms and epilepsy. However, little is known about the interaction between the purine nucleoside A2A receptor and rate-limiting enzyme ecto-5'-nucleotidase/CD73 and epilepsy from the genetic polymorphism aspect. The aim of the study is to evaluate the impact of A2AR and CD73 polymorphisms on epilepsy cases. The study group encompassed 181 patients with epilepsy and 55 healthy volunteers. A significant correlation was confirmed between CD73 rs4431401 and epilepsy (p < 0.001), with TT genotype frequency being higher and C allele being lower among epilepsy patients in comparison with healthy individuals, indicating that the presence of the TT genotype is related to an increased risk of epilepsy (OR = 2.742, p = 0.006) while carriers of the C allele demonstrated a decreased risk of epilepsy (OR = 0.304, p < 0.001). According to analysis based on gender, the allele and genotype of rs4431401 in CD73 were associated with both male and female cases (p < 0.0001, p = 0.026, respectively). Of note, we found that A2AR genetic variants rs2267076 T>C (p = 0.031), rs2298383 C>T (p = 0.045), rs4822492 T>G (p = 0.034), and rs4822489 T>G (p = 0.029) were only associated with epilepsy in female subjects instead of male. It is evident that the TT genotype and T allele of rs4431401 in CD73 were genetic risk factors for epilepsy, whereas rs2267076, rs2298383, rs4822492, and rs4822489 polymorphisms of the A2AR were mainly associated with female subjects. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

49. Astrocytic and Oligodendrocytic P2X7 Receptors Determine Neuronal Functions in the CNS

Author

Zhao, Ya-Fei, Tang, Yong, and Illes, Peter

Subjects
Cellular and Molecular Neuroscience, signaling molecules, astrocytes, oligodendrocytes, neurons, Review, ddc:610, Molecular Biology, P2X7 receptors, P2X7 receptors, astrocytes, oligodendrocytes, neurons, signaling molecules, Neuroscience
Abstract

P2X7 receptors are members of the ATP-gated cationic channel family with a preferential localization at the microglial cells, the resident macrophages of the brain. However, these receptors are also present at neuroglia (astrocytes, oligodendrocytes) although at a considerably lower density. They mediate necrosis/apoptosis by the release of pro-inflammatory cytokines/chemokines, reactive oxygen species (ROS) as well as the excitotoxic (glio)transmitters glutamate and ATP. Besides mediating cell damage i.e., superimposed upon chronic neurodegenerative processes in Alzheimer’s Disease, Parkinson’s Disease, multiple sclerosis, and amyotrophic lateral sclerosis, they may also participate in neuroglial signaling to neurons under conditions of high ATP concentrations during any other form of neuroinflammation/neurodegeneration. It is a pertinent open question whether P2X7Rs are localized on neurons, or whether only neuroglia/microglia possess this receptor-type causing indirect effects by releasing the above-mentioned signaling molecules. We suggest as based on molecular biology and functional evidence that neurons are devoid of P2X7Rs although the existence of neuronal P2X7Rs cannot be excluded with absolute certainty.

Published
2021

50. Increasing Efficiency of Repetitive Electroacupuncture on Purine- and Acid-Induced Pain During a Three-Week Treatment Schedule

Author

Li, Jie, Zhang, Ying, Illes, Peter, Tang, Yong, and Rubini, Patrizia

Subjects
electroacupuncture, analgesia, subacute pain, P2X3 receptors, P2X7 receptors, ASIC channels 3, ddc:610
Abstract

Acupuncture (AP) is an important constituent of the therapeutic repertoire of traditional Chinese medicine and has been widely used to alleviate chronic painful conditions all over the world. We studied in rats the efficiency of electroacupuncture (EAP) applied to the Zusanli acupoint (ST36) as an analgesic treatment over a 3-week period of time on purine (α,β-methylene ATP, dibenzoyl-ATP)- and acid (pH 6.0 medium)-induced pain in the rat paw. The two ATP derivatives stimulated P2X3 and P2X7 receptors, respectively, while the slightly acidic medium stimulated the “acid-sensitive ion channel 3” (ASIC3). It was found that the P2X7 receptor and ASIC-mediated pain was counteracted by EAP with greater efficiency at the end than at the beginning of the treatment schedule, while the P2X3 receptor–mediated pain was not. Our findings have important clinical and theoretical consequences, among others, because they are difficult to reconcile with the assumption that AP is primarily due to the release of peripheral and central opioid peptides causing the well-known tolerance to their effects. In consequence, AP is a convenient therapeutic instrument to treat subacute and chronic pain.

Published
2021

Catalog

Books, media, physical & digital resources
See catalog results