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7. Blastocyst-like Structures in the Peripheral Retina of Young Adult Beagles.

Author

Ikeda, Tsunehiko, Jin, Denan, Takai, Shinji, Nakamura, Kimitoshi, Nemoto, Emika, Kojima, Shota, and Oku, Hidehiro

Subjects
*YOUNG adults, *BEAGLE (Dog breed), *RHODOPSIN, *RETINA, *TRANSCRIPTION factors
Abstract

In this immunohistological study on the peripheral retina of 3-year-old beagle dogs, excised retina specimens were immunostained with antibodies against nestin, Oct4, Nanog, Sox2, CDX2, cytokeratin 18 (CK 18), RPE65, and YAP1, as well as hematoxylin and DAPI, two nuclear stains. Our findings revealed solitary cysts of various sizes in the inner retina. Intriguingly, a mass of small round cells with scant cytoplasms was observed in the cavity of small cysts, while many disorganized cells partially occupied the cavity of the large cysts. The small cysts were strongly positive for nestin, Oct4, Nanog, Sox2, CDX2, CK18, and YAP1. RPE65-positive cells were exclusively observed in the tissue surrounding the cysts. Since RPE65 is a specific marker of retinal pigment epithelial (RPE) cells, the surrounding cells of the peripheral cysts were presumably derived from RPE cells that migrated intraretinally. In the small cysts, intense positive staining for nestin, a marker of retinal stem cells, seemed to indicate that they were derived from retinal stem cells. The morphology and positive staining for markers of blastocyst and RPE cells indicated that the small cysts may have formed structures resembling the blastocyst, possibly caused by the interaction between retinal stem cells and migrated RPE cells. [ABSTRACT FROM AUTHOR]

Published
2024
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50. A Case of Fungal Endophthalmitis Caused by Paecilomyces lilacinus that Might Have Spread from the Sclera into the Intraocular Space

Author

Tara, Akiko, Kobayashi, Takatoshi, Kohmoto, Ryohsuke, Fukumoto, Masanori, Sato, Takaki, Kida, Teruyo, Ooi, Yukimasa, and Ikeda, Tsunehiko

Subjects
conjunctival abscess, genetic structures, lcsh:Ophthalmology, lcsh:RE1-994, fungal endophthalmitis, vitrectomy, Case Report, sense organs, eye diseases, paecilomyces lilacinus
Abstract

The aim of this report was to describe a case of fungal endophthalmitis possibly caused by Paecilomyces lilacinus(PL) penetrating the sclera from a conjunctival abscess. This case study involved an 83-year-old male patient with a past history of scleral buckling, subtenon steroid injection, and cataract surgery. The vitreous opacity and a conjunctival abscess appeared in the inferonasal quadrant of his right eye at 5 months after cataract surgery. PL was isolated from a cultured conjunctival discharge specimen obtained from the patient's right eye. Although the treatment with antifungal agents relieved the conjunctival abscess, the vitreous opacity became worse. Thus, vitrectomy was subsequently performed. Intraoperative findings revealed severe vitreous opacity in the inferonasal quadrant, adjacent to the sclera at the site of the conjunctival abscess. Our findings indicate that fungal endophthalmitis appeared to have been caused by PL in the conjunctival abscess that may have penetrated the sclera and spread into the intraocular space.

Published
2020

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