1. Absence of glaucoma in DBA/2J mice homozygous for wild-type versions of Gpnmb and Tyrp1
- Author
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Richard S. Smith, Michael G. Anderson, Richard T. Libby, Simon W. M. John, Gareth R. Howell, I. M. Cosma, Lawriston A. Wilson, and Jeffrey K. Marchant
- Subjects
Intraocular pressure ,Genotype ,genetic structures ,lcsh:QH426-470 ,Glaucoma ,Disease ,Biology ,Mice ,03 medical and health sciences ,0302 clinical medicine ,Genetics ,medicine ,Animals ,Genetics(clinical) ,Eye Proteins ,Intraocular Pressure ,Genetics (clinical) ,030304 developmental biology ,0303 health sciences ,Membrane Glycoproteins ,GPNMB ,Homozygote ,Wild type ,Optic Nerve ,medicine.disease ,Mice, Mutant Strains ,eye diseases ,3. Good health ,lcsh:Genetics ,Iris Diseases ,Mice, Inbred DBA ,Optic nerve ,sense organs ,Oxidoreductases ,030217 neurology & neurosurgery ,Research Article - Abstract
Background The glaucomas are a common but incompletely understood group of diseases. DBA/2J mice develop a pigment liberating iris disease that ultimately causes elevated intraocular pressure (IOP) and glaucoma. We have shown previously that mutations in two genes, Gpnmb and Tyrp1, initiate the iris disease. However, mechanisms involved in the subsequent IOP elevation and optic nerve degeneration remain unclear. Results Here we present new mouse strains with Gpnmb and/or Tyrp1 genes of normal function and with a DBA/2J genetic background. These strains do not develop elevated IOP or glaucoma with age. Conclusion These strains provide much needed controls for studying pathogenic mechanisms of glaucoma using DBA/2J mice. Given the involvement of Gpnmb and/or Tyrp1 in areas such as immunology and tumor development and progression, these strains are also important in other research fields.
- Published
- 2007