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Rhinorrhea is a predominant symptom of nasal inflammation that comes from the nose's activation glands to produce mucus. Objective: To found out the effectiveness of providing nasal irrigation educational videos on the recovery rate of rhinorrhea patients at the Ibnu Sina Gresik Hospital. Methods: This research used a quasi-experimental design was applied by employing Jamovi to do univariate analysis in describing the characteristics of each variable, such as age, gender, level of education, and Rhinorrhea as the predominant disease. In addition, bivariate analysis used chi-square to test the effectiveness differentiation of giving nasal irrigation video to patients who received the video and patients who did not. Results: Univariate analysis reported that 21 patients were male (52,5%), 12 patients (47,5%) were between 20-44 years old, 16 patients (40%) experienced high school level, and 11 patients (27,5%) had vasomotor rhinitis disease. Chi-square analysis showed a significance value of 0.685, indicating no difference in the recovery rate between rhinorrhea patients receiving nasal irrigation video and those not receiving it. Conclusion: There is no significant difference in the recovery of rhinorrhea outpatients who received and those who did not receive educational videos about nasal irrigation.Keywords: educational video, rhinorrhea, recovery rate

This study aims to find out how much the application of the K-NN method and the accuracy value obtained by the K-NN method in clarifying data of Tuberculosis patients. This research focuses on improving public health and developing science to help people prevent and overcome tuberculosis. This type of research is quantitative. The literature study used is the documentation study. The method used by the K-Nearest Neighbor Algorithm. The results of the study showed that the process of applying data mining for the classification of tuberculosis disease using the K-Nearest Neighbor method obtained a final result of 80% accuracy. Thus, it can be concluded that the K-Nearest Neighbor algorithm is good.

BACKGROUND AND OBJECTIVES: Cattle farming is an important pillar of dry climate agriculture. Cattle farming has even become the main engine of the community's economy. Currently, there are significant obstacles in the implementation of ecological, economic, technological, and infrastructural dimensions, alongside legal and institutional frameworks, that are essential for promoting sustainable livestock farming practices. Specific studies on different dimensional attributes affecting the sustainability of beef cattle are required. The objective of this study is to investigate different factors within four dimensions that affect the sustainability of cattle farming practices in dry climatic conditions.METHODS: This study was conducted using an interview approach to respondents using a questionnaire or list of questions. The questionnaire contains questions on 37 dimensional attributes, including ten environmental, ten economic, ten technological and infrastructure attributes, and seven legal and institutional attributes. A range of responses was collected from individuals engaged in livestock management in the dry climatic conditions of Timor Tengah Utara Regency. The data that has been collected is analyzed employing Multidimensional Scaling and expedited appraisal software. To evaluate sustainability and leverage attributes, Monte Carlo analysis and the alternating least squares algorithm are applied.FINDINGS: The study's outcomes revealed that the sustainability index pertaining to beef cattle farming in dry climates recorded an average score of 53.09 percent. This finding is based on the economic dimension of 45.58 percent, the environmental dimension of 54.18 percent, the technology and infrastructure dimension of 35.15 percent, and the legal and institutional dimension of 77.46 percent. The sustainability index, reflecting the technology and infrastructure aspects, ranks the lowest, primarily because the technological advancements necessary for achieving sustainable livestock farming are still underdeveloped. The availability of livestock waste processing technology is still relatively low and has not been processed optimally. This situation has an impact on the environment.CONCLUSION: The sustainability index of dry climate beef cattle farming is greatly influenced by the attributes of technology and infrastructure dimensions. The enhancement of sustainability in the future necessitates careful consideration of specific factors, including the accessibility of waste and product processing technologies, advancements in information technology, and the development of road infrastructure. Attributes in the legal and institutional dimensions are the main factors supporting beef cattle's sustainability. Optimizing extension services by increasing the number of livestock extension workers is crucial in accelerating the dissemination of eco-friendly livestock technoloBeef Cattle; Dry climate; Environmentally friendly; Multidimensional scaling (MDS); Sustainability assessmenty and innovation.

Leprosy (Morbus Hansen) is a chronic, severe infectious disease caused by the Mycobacterium leprae that mostly affects the skin, mucosa, eyes, and nerves. Despite the availability of effective treatment, leprosy has become a major public health problem in many developing countries.

Earthworm (Lumbricus rubellus) farming offers a unique solution for poverty alleviation in rural Indonesia by transforming agricultural waste into economic opportunities while supporting sustainable farming practices. Empowering these farmers is crucial for enhancing their cultivation techniques and economic outcomes. This study examines the key factors that influence the behavior of empowered earthworm farmers, using the Theory of Planned Behavior (TPB) as its framework. Conducted in Temanggung Regency, Central Java Province, Indonesia, in 2023, the study involved 201 respondents selected through a snowball sampling method. Information was gathered via a survey and then examined using PLS-SEM. The findings indicate that empowerment programs significantly influence farmers’ attitudes, social norms, and perceived behavioral control, which drive their intention to become empowered. Empowered intentions and perceived behavioral control strongly predict farmers’ empowered behaviors, which, in turn, enhance their economic well-being. Notably, the study also found that farmers' personality traits do not moderate the relationship between intention and behavior, suggesting that empowerment programs are broadly effective across different farmer profiles. This study underscores the importance of empowerment initiatives in promoting sustainable farming practices, improving farmers' livelihoods, notably the livelihood of farmers, as the empowerment program is based on dynamic open innovation.

Pesantren sebagai lembaga pendidikan asli Indonesia telah terbukti menghasilkan ahli dibidangnya selama ratusan tahun. Sistem pendidikan tinggi modern saat ini seringkali tidak memprioritaskan pembentukan manusia ideal, melainkan lebih terfokus pada pembentukan individu yang berorientasi materi dan kurang memiliki nilai-nilai spiritual. Permasalahan ini menuntut upaya serius dalam memperkuat ketentraman dan kedamaian hidup, baik melalui pengawalan dan pengembangan sumber daya manusia, maupun melalui revolusi dalam kinerja pendidik dan sistem pendidikan tinggi secara menyeluruh. Penelitian ini bertujuan untuk melihat bagaimana Pesantren Education as Indonesia's Indigenous Heritage: Nurturing Moral Education in the Digital Era dan Sumber daya Manusia nya memiliki capabilitydalam memanage dan bertahan di digital era saat ini.. Metode penelitian ini ialah kualitatif dan kuantitatif, dimana penulis memakai studi pustaka dan studi kasus yang mengambil tempat di Pondok Modern Darussalam Gontor yang mana representasi dari pesantren yang memiliki perguruan tinggi unggul di Indonesia. Hasil penelitian ini adalah Dalam model ini, Pendidikan karakter, Pengembangan karir dan peningkatan kinerja sumber daya manusia islam, Pengembangan sumber daya manusia islam, dan Pondok Modern Darussalam Gontor menjadi bagian penting dari program-program yang ditawarkan. Selain itu, program ini juga mencakup nilai-nilai seperti Qurrota A’yun, Islamic human resource development, Keikhlasan, Kemandirian, Kemodernan, Kepemimpinan dan keberhasilan dalam konteks islam, Kepesantrenan, Kesederhanaan, dan Kultur dan struktur. Gontor berusaha untuk menciptakan lingkungan belajar yang sesuai dengan prinsip-prinsip model pembelajaran Islami untuk pengembangan SDM dan nilai-nilai Islam menjadi pedoman utama dalam pengelolaan SDM, sementara pengembangan karir berbasis syariat Islam juga diutamakan untuk membentuk sumber daya manusia Islam yang berkualitas. Aspek profesionalisme Islami juga ditekankan guna memastikan integrasi nilai-nilai Islam dalam tindakan dan perilaku profesional

This study is aimed to investigate the effectiveness of problem-based learning combined with simulation on students' problem-solving and creative thinking skills. By employing a quasi-experimental design, this study used essay and problem-based tests as the instruments to evaluate problem-solving and creative thinking skills of 192 students. These students were categorized into three groups: experimental group I (n = 68) receiving instruction using problem-based learning combined with simulation, experimental group II (n = 60) receiving instruction with problem-based learning only, and control group (n = 64) receiving instruction with a conventional method. Using a multivariate analysis of covariance, the results revealed that problem-solving and creative thinking skills taught by problem-based learning combined with simulation were significantly improved as compared to those in experimental group II and control group. In addition, a positive relationship was identified between students' problem-solving skills and their creative thinking skills. Ultimately, this study shows that instruction using problem-based learning combined with simulation method is much more effective than using either problem-based learning only or a conventional teaching method.

OBJECTIVES:. Anemia has been associated with an increased risk of both cardiac arrest and stroke, frequent complications of COVID-19. The effect of hemoglobin level at ICU admission on a composite outcome of cardiac arrest or stroke in an international cohort of COVID-19 patients was investigated. DESIGN:. Retrospective analysis of prospectively collected database. SETTING:. A registry of COVID-19 patients admitted to ICUs at over 370 international sites was reviewed for patients diagnosed with cardiac arrest or stroke up to 30 days after ICU admission. Anemia was defined as: normal (hemoglobin ≥ 12.0 g/dL for women, ≥ 13.5 g/dL for men), mild (hemoglobin 10.0–11.9 g/dL for women, 10.0–13.4 g/dL for men), moderate (hemoglobin ≥ 8.0 and < 10.0 g/dL for women and men), and severe (hemoglobin < 8.0 g/dL for women and men). PATIENTS:. Patients older than 18 years with acute COVID-19 infection in the ICU. INTERVENTIONS:. None. MEASUREMENTS AND MAIN RESULTS:. Of 6926 patients (median age = 59 yr, male = 65%), 760 patients (11.0%) experienced stroke (2.0%) and/or cardiac arrest (9.4%). Cardiac arrest or stroke was more common in patients with low hemoglobin, occurring in 12.8% of patients with normal hemoglobin, 13.3% of patients with mild anemia, and 16.7% of patients with moderate/severe anemia. Time to stroke or cardiac arrest by anemia status was analyzed using Cox proportional hazards regression with death as a competing risk. Covariates selected through clinical knowledge were age, sex, comorbidities (diabetes, hypertension, obesity, and cardiac or neurologic conditions), pandemic era, country income, mechanical ventilation, and extracorporeal membrane oxygenation. Moderate/severe anemia was associated with a higher risk of cardiac arrest or stroke (hazard ratio, 1.32; 95% CI, 1.05–1.67). CONCLUSIONS:. In an international registry of ICU patients with COVID-19, moderate/severe anemia was associated with increased hazard of cardiac arrest or stroke.

This research explores a contemporary approach to managing Oral Squamous Cell Carcinoma (OSCC) by integrating nano-technology into herbal production, combining Bischofia javanica leaves and Phaleria macrocarpa fruits. Benzo[a]pyrene (BaP)-induced OSCC rats were treated with nano herbals from Bischofia javanica leaves, Phaleria macrocarpa fruits, a combination of both, and Vitamin C as a control. Blood and organ analyses were compared with negative and positive controls. BaP induction in OSCC revealed cell transformation into carcinoma, confirmed by Papanicolaou staining. OSCC induction also caused significant changes in Complete Blood Count (CBC) and serum lipid profile. Nano herbals from both plants showed potential in reducing hematological and lipid damage in OSCC, especially in white blood cells, red blood cells, hemoglobin, and platelets. Statistical analysis also indicated that the combination of nano herbals was more effective in reducing (Low-Density Lipoprotein) LDL and total cholesterol levels than uncombined use while increasing (High-Density Lipoprotein) HDL levels comparable to Vitamin C. Liver and kidney functions were also significantly affected by OSCC, with nano herbals showing potential in normalizing albumin levels and positively impacting liver enzymes. In conclusion, both individually and in combination, nano herbals from Bischofia javanica leaves, and Phaleria macrocarpa fruits have the potential to be a promising treatment strategy for OSCC.

The development of mobile commerce (m-commerce) applications has indicated a shift in goals from ease-of-use to sustainable use in the future. This shift has prompted changes in the combination of attributes that constitute the usability of m-commerce applications. This study developed an m-commerce usability model that combines functional and non-functional attributes. The research data was collected using questionnaires distributed to users living in Jakarta and was processed using the Partial Least Squares Structural Equation Modeling (PLS-SEM) technique. The results demonstrate that efficiency, satisfaction, and effectiveness can explain the usability of m-commerce applications. This study proved that three non-functional usability attributes – productivity, navigation, and memorability – have a positive effect on efficiency, while two functional attributes of usability – content and security – positively influence effectiveness. The study further proved that beside non-functional attributes, functional attributes also play an important role in increasing the user experience in the m-commerce context and thereby contribute to improving the usability of m-commerce systems and the continuance intention. The overall results of the study can be used in developing strategies for m-commerce application developers to design applications that can satisfy users and help them complete their tasks correctly and efficiently.

This article aims to understand various efforts to improve public services through deregulation. For example, the Mayor of Pekalongan shared complaints from fishermen who felt that the existence of the state and government made it difficult because to take care of sea permits alone had to deal with 17 different agencies. The problem centers on the obstacles to improving public services through deregulation and the factors that cause overregulation in Indonesia. This study determined the obstacles to public services and over-regulation. The data used are secondary data collected through literature studies and analyzed qualitatively. This study concludes that the Government has made various efforts to improve intermediate public services through deregulation by enacting several laws and regulations that unify the material of previous laws and regulations. Overregulation occurs in Indonesia due to the unclear development of authority between various institutions. There are still many overlapping laws and regulations in regulating various affairs so the applicable regulations can be said to have been too many. Therefore, there needs to be a firm policy in the division of authority of regulators so that there is no more over-regulation because there are no more overlapping regulations.

Introduction: Treatment of impairment is an important step to prevent advanced neurological deficits in ischemic stroke medicine. Ischemic stroke patients with likely worsening neurological deficits should receive appropriate interventions. Therefore, this study aimed to examine predictors that can identify worsening neurological deficits. Methods: This study used a cross-sectional design on 74 hospitalized ischemic stroke patients at Abdoel Wahab Sjahranie Regional Hospital, Samarinda, in 2019. The worsening of neurological deficits was based on the progression of the National Institutes of Health Stroke Scale (NIHSS) scores at hospital admission and discharge. Age, hemoglobin level, hematocrit value, gender, smoking history, blood pressure, and hyperglycemic state were based on patient data at the beginning of hospital admission. The Chi-Square and Fisher’s exact tests were used in bivariate analysis. Results: The results showed that age had a significant association with the worsening of neurological deficits in ischemic stroke patients (p = 0.024). Hemoglobin level, hematocrit value, gender, smoking history, blood pressure, and hyperglycemic state showed no relationship with worsening neurological deficits in ischemic stroke patients (p > 0.05). Conclusion: Age can serve as a predictor of worsening neurological deficits in ischemic stroke patients, with those aged over 45 years old having a higher risk. Meanwhile, the other factors were not associated with a worsening neurological deficit in ischemic stroke patients.

This study explores the chronic toxicity of nano-formulated Bischofia javanica leaves, a plant with pharmacological significance in Indonesia, following OECD guidelines 452. Graded doses (2, 4, 6, and 8 g/kg BW) of nano-formulated Bischofia javanica were administered to the treatment groups for 60 days, while the control group (K-) received only water. On the 61st day, the mice were euthanized, and samples for biochemical, hematological, and histopathological analysis were collected. Statistical analysis involved one-way ANOVA and Tukey’s post hoc tests. Graded doses of nano-formulated Bischofia javanica leaves caused significant alterations in liver function. Doses between 2 and 4 g/kg BW improved liver histology and physiological markers. Higher doses (6 to 8 g/kg BW) led to liver dysfunction and histological degeneration, characterized by substantial fatty alterations, intracellular fat accumulation in hepatocytes, and compromised central blood vessels and sinusoids. The lungs showed signs of alveolar inflammation, epithelial exfoliation, debris, and the accumulation of inflammatory cells in alveolar spaces. Lower doses showed uniformly distributed cardiac blood vessels, while higher doses resulted in heart hemorrhages and amorphous exudates. Except for high doses, which significantly elevated specific liver damage indicators, no other levels of Bischofia javanica caused treatment-related mortality or significant alterations in hematological and biochemical parameters. Blood sugar levels remained stable across the dose range. In conclusion, moderate doses of nano-formulated Bischofia javanica leaf extracts can enhance physiological functions positively. However, caution is necessary when contemplating high doses, as they can cause dysfunction or damage vital organ systems.

The swamp buffalo is a valuable genetic resource and an important source of animal protein in Indonesia. Unfortunately, their population is decreasing due to problems attributed to conventional farming systems. The objective of the study was to examine the sustainability of swamp buffalo farming and identify the attributes that influence its sustainability. Data were collected through a focus group discussion involving experts and business actors in swamp buffalo farming and a survey on buffalo farmers. The study examined 52 attributes within 6 dimensions: ecological, economic, social, technological, institutional, and welfare dimensions. The data were analysed using multidimensional scaling through the Rapid Appraisal for Swamp Buffalo technique. The results of the study demonstrate that swamp buffalo farming in Hulu Sungai Utara (HSU), Hulu Sungai Selatan (HSS), and Hulu Sungai Tengah (HST) districts in South Kalimantan province has sustainability indices of 51.70, 53.13, and 48.87%, respectively. This study identified 12 leverage attributes that are very influential to the sustainability of swamp buffalo farming, i.e., climatic conditions, land suitability, marketing, income from swamp buffalo farming, mutual assistance, education level, processing technology, reproduction technology, the role of local government, capital institutions, programs from central government, and farmers’ welfare. Swamp buffalo farming in HSU and HSS is moderately sustainable, while in HST, it is less sustainable, suggesting improvement in the key factors influencing the sustainability of swamp buffalo farming. This study offers valuable insights for the government in formulating policies and programs for developing swamp buffalo farming and conserving swamp buffalo germplasm.

Extracts of Phaleria macrocarpa have been used for years in traditional medicine and have been evaluated scientifically as well. This study aimed to evaluate the chronic toxicity level of nano herbal Phaleria macrocarpa and its effect on the changes in hematology, biochemistry, electrolytes, and organ histopathology. High Energy Milling (HEM) produced nano herbal Phaleria macrocarpa. By giving nano herbal Phaleria macrocarpa at doses of 300, 600, and 900 mg/kg BW for 56 days, the mice’s blood was collected for the hematological and electrolyte parameters. The kidney and liver were assessed for biochemical parameters. As a result, the nano herbal Phaleria macrocarpa affected the histopathological organs, hematological, biochemical, and electrolyte parameters at an appropriate dose of 300–600 mg/kg BW. The maximum period of the administration this herbal medicine is one month. Therefore, with the correct dose and period of administration, this plant can be used as herbal medicine in the future.

The spiritual growth of God's people at Gereja Kristen Setia Indonesia (GKSI) Sanggau, West Kalimantan, is urgently needed. Christian educators serving at GKSI Sanggau have an important role to play in guiding the spiritual growth of the people. To realize the spiritual growth of God's people at GKSI Sanggau, Christian educators need to play a proactive role in conveying the truth of God's word, teaching the truth of God's word, conducting evangelism, carrying out counseling, and make visits to all God's people in their homes so as to share the truth of God's word. The problem posed is that some of God's people have not experienced spiritual growth, so Christian educators are needed to carry out their role well in overcoming various problems faced by God's people. The issues include doctrinal problems or teaching God's word at all, personal problems with families related to inheritance, problems of laziness to attend worship to God because they prioritize traditions or customs and traditional beliefs more, close their hearts when God's word is preached in the form of teaching, some do not have good habits in reading God's word, are less effective in praying, and may often tend to prioritize their interests rather than glorifying God's name. This study aims to interrogate the role of Christian educators in guiding the spiritual growth of God's people at GKSI Sanggau, West Kalimantan so that God's people can experience spiritual growth according to the truth of God's word. This research uses qualitative methods through data processing of interviews and relevant literature. The findings of this study are that the more serious Christian educators are in guiding the spiritual growth of God's people, the more their spirituality will take root, grow, and experience significant life changes.

Penelitian ini bertujuan untuk mengetahui Hubungan antara Dukungan Sosial Dengan Stres Kerja Perawat Instalasi Bedah Sentral RSUP Haji Adam Malik. Jenis penelitian yang digunakan adalah pendekatan kuantitatif. Populasi dalam penelitian ini adalah 100 orang. Teknik sampling yang dipakai yaitu total sampling. Skala stres kerja disusun berdasarkan aspek-aspek stres kerja. Skala dukungan sosial diukur berdasarkan aspek dukungan sosial. Diperoleh nilai signifikansi sebesar 0.000 nilai tersebut 0.05 maka hipotesis diterima, yang artinya terdapat hubungan antara dukungan sosial dengan stres kerja. Pada angka koefisien korelasi sebesar -0.473, artinya tingkat korelasi antara variabel dukungan sosial dengan stres kerja adalah sebesar -0.473 masuk dalam kriteria tinggi. Nilai koefisien korelasi sebesar -0.473, dimana nilai tersebut negatif yang artinya hubungan kedua variabel tersebut berlawanan. Dengan demikian dapat disimpulkan semakin tinggi nilai dari variabel dukungan sosial maka semakin rendah stres kerja. Koefisien determinan (r2) dari hubungan antara variabel bebas dan variabel terikat adalah r2= 0,225. Ini menunjukkan bahwa dukungan sosial berdistribusi sebesar 22,5% terhadap stres kerja.

Cervical carcinoma is one of the most common malignant carcinomas around the world, including Indonesia. Rhodomyrtus tomentosa is an herbal medicine that is often used in Asia as a therapeutic agent to stop cancer metastases. The process of neoangiogenesis in cervical cancer depends on VEGFR activity. Increased TGFβ1 production is also linked to cervical cancer, suggesting that gene inactivation contributes to the emergence of cervical carcinoma. Group C- was the control group, Group C+ was the cancer model group, CER100 was the group of rats with cancer + 100 mg/kg body weight (BW) of R. tomentosa, CER200 was the group of rats with cancer + 200 mg/kg BW of R. tomentosa, and CER400 was the group of rats with cancer + 400 mg/kg BW R. tomentosa. Rats were dissected after administration of R. tomentosa for 30 days. Immunohistochemical staining of the cervical tissue was performed with TGFβ1 and VEGFR antibodies. VEGFR expression was significantly different from TGFβ1 expression (p < 0.01). The highest expression was observed at the lowest dose of R. tomentosa (100 mg/kg BW), and the lowest expression was observed at 200 and 400 mg/kg BW. The administration of R. tomentosa can repair tissue damage and decrease the expression of TGFβ1 and VEGFR via histopathological parameters, indicating the importance of the activity of these proteins in the development of neoangiogenesis in cervical cancer.

Penelitian ini bertujuan menggali lebih dalam tentang proses reparasi dan kustom instrumen tiup logam di Indonesia. Penelitian ini dilakukan dengan mengumpulkan data dan informasi dengan menggunakan metode kualitatif yang dimana pada metode tersebut disertai dengan beberapa teknik análisis konten. Hasil penelitian ini menunjukan bahwa reparasi terdiri dari 2 jenis yaitu perawatan dan perbaikan. Perawatan seperti katup, tuning slide, slide trombon harus dalam keadaan terlumasi minyak; membersihkan instrumen musik tiup logam dengan cara dicuci; menjaga agar bagian luar bersih dari sidik jari dan minyak lainnya dengan kain poles; mengosongkan ludah pada instrumen musik tiup logam setiap kali sebelum memasukkan instrumen ke dalam kotak; mouthpiece harus dicuci menggunakan sikat corong sebulan sekali; dan tidak menyimpan instrumen tiup logam dalam case dalam jangka waktu yang lama. Perbaikan seperti melepaskan mouthpeace stuck menggunakan mouthpeace puller; soft soldering dan hard soldering; penggantian suku cadang seperti pegas, guide katup, katup dan casing katup, mengatur ulang posisi tabung slide; pengaplikasian panas dan pembongkaran lengkap; serta menggosok dan menumbuk penyok sampai logam halus kembali. Kustomisasi dilakukan dengan membuat penyetel bel atau merubah bentuk posisi bel, merubah ukuran dan material tabung pipa, menggantikan desain counterweight, membuat ukuran dan bentuk desain baru valve caps, melapisi kuningan dengan silver, gold, nickel, rose, atau raw brass, dan menyemprotkan lacquer.

The aim of this study was to identify the antibacterial activity potention of gamal leaf (Gliricidia sepium) ethanol extract against Escherichia coli growth which isolated from Olive Ridley Sea Turtle (Lepidochelys olivacea) semi-natural nest in Boom beach, Banyuwangi. The antibacterial test used disk diffusion method. Oxytetracycline 30 µg (Oxoid CT0041B) was used as the Positive Control (K+). CMC Na 0,5% was used as the Negative Control (K-). The treatment (P1, P2, P3, P4) used various concentrations of gamal leaves ethanol extract, which is 40%, 50%, 60%, and 70%. The study assigned six treatments and four replication. The obtained data were analyzed by ANOVA, then continued with the DUNCAN test if the results showed significant differences (p

The machine maintenance strategy is very important in manufacturing, mining, and other industries so an appropriate maintenance strategy is needed based on industrial operating conditions. In this paper, a Proactive maintenance strategy is presented, in which this strategy requires the identification of vibrations, and the identification of vibrations is divided into two methods, there are the identification of vibrations in the time domain and the identification of vibrations based on the frequency domain. Identification in the time domain is usually done in analyzing gears because of so much noise in the frequency domain, while identification in the frequency domain is used to analyze vibrations in cases of unbalance, misalignment, bearing defects, cavitation, and damage to electric motors. This paper briefly presents the time domain and frequency domain differences and two case studies that happened on PT. Freeport Indonesia. The first case is the investigation of bearing damage to the conveyor using vibration signals in the frequency domain, while the second case is the investigation of gear damage using the time domain that occurs in the crusher.

Initiating antiretroviral therapy (ART) in Indonesia poses major challenges, with limited studies on specific ART initiation barriers and facilitators. Using a socioecological approach, we explored, through semi-structured interviews, the perspectives of 67 participants: 17 people with HIV not (yet) on ART, 30 people with HIV on treatment, and 20 HIV service providers (HSPs). Fears emerged as pervasive barriers to initiation encompassing, at the intrapersonal level, (irrational) fears of negative medical and non-medical consequences. At the health system level, fears were linked to concerns about bureaucracy and insufficient universal coverage. On a societal level, fears stemmed from prevalent myths, misinformation on social media, and the impact of COVID-19. Interestingly, fear also served as a facilitator to initiation. At the intrapersonal level, initiation was driven by a fear of deteriorating health or death due to AIDS-related conditions. At the interpersonal level, buddies and HSPs leveraged to motivate initiation. At the societal level, accurate yet fear-inducing information on social media stimulated initiation. Perspectives differed between people with HIV and HSP, with people with HIV emphasizing barriers on intrapersonal to health system levels, while HSP focused mostly on intrapersonal and interpersonal barriers, albeit recognizing the crucial role of health systems. [ABSTRACT FROM AUTHOR]

The crucial challenge in herbal medicine development lies in ensuring the safety, quality, and effectiveness of herbal materials to comply with the regulatory standards in the herbal medicine industry. This research aims to synthesize nano-based herbal medicine by combining two medicinal plants: Bischofia javanica leaves and Phaleria macrocarpa fruits. Through the High-Energy Milling (HEM) process, both materials are transformed into nanoparticles to enhance the solubility and bioavailability of active compounds. The herbal medicine standards are measured through Scanning Electron Microscopy (SEM), Particle Size Analysis (PSA), and Fourier-transform infrared spectroscopy (FTIR) tests. The SEM analysis results indicate optimal dispersion of nanoparticles, while PSA analysis reveals a reduction in particle size and increased homogeneity after nanonization with HEM. FTIR analysis results show various functional groups in nanoparticles, indicating the potential interaction between the combined components. The effectiveness of nanoparticles in the Rattus norvegicus Oral Squamous Cell Carcinoma (OSCC) model demonstrates an increase in lipid profile comparable to the effectiveness of Vitamin C. These findings highlight the potential of combined herbal treatment with nanoparticles produced by HEM, offering better efficacy and potential safety improvement, particularly in addressing lipid metabolism disorders.

Context: Physical exercise with maximum intensity to fatigue can cause impaired immunity. Gastrocnemius muscle damage is found in eccentric activities in sports. Vitis gracilis has been proven as a healing agent for degenerative diseases. Aims: To determine whether the V. gracilis Wall extract can recovery of gastrocnemius muscle cells of Mus musculus through reduced inflammatory cells and cytochrome c expression. Methods: The studies turned into performed in 5 groups of remedies withinside the study. The remedy groups consisted of T1: Negative control (no treatment), T2: Positive control (Swim Until the First Sink/SUFS) + Vit. C 0.2 mg/kg BW, T3: SUFS + 50 g/kg BW of V. gracilis, T4: SUFS + 75 g/kg BW of V. gracilis and T5: SUFS + 100 g/kg BW of V. gracilis. Mice were dissected and then the leg were taken for analysis of gastrocnemius muscle cells in immunohistochemistry. Results: There was a significant difference (p

Abstract Background Dihydroartemisinin–piperaquine (DHA–PPQ) has been adopted as first-line therapy for uncomplicated falciparum malaria in Indonesia since 2010. The efficacy of DHA–PPQ was evaluated in 2 sentinel sites in Keerom District, Papua and Merangin District, Jambi, Sumatra from April 2017 to April 2018. Methods Clinical and parasitological parameters were monitored over a 42-day period following the World Health Organization standard in vivo protocol and subjects meeting the inclusion criteria were treated with DHA–PPQ once daily for 3 days, administered orally. Results In Papua, 6339 subjects were screened through active and passive cases detection. Of the 114 falciparum and 81 vivax cases enrolled, 102 falciparum and 80 vivax cases completed the 42 day follow up, and 12 falciparum and 1 vivax cases were either lost to follow up or withdrawn. Kaplan–Meier analysis of microscopy readings of 102 falciparum cases revealed 93.1% (95% CI 86.4–97.2) as Adequate Clinical and Parasitological Response (ACPR). No delay in parasite clearance nor severe adverse reaction was observed. Recurrent parasites of Plasmodium falciparum were detected in 7 cases and categorized as late treatment failures (LTF) at days 21, 35, and 42 and one of which was reinfected by Plasmodium vivax at day 42. Two cases were confirmed as recrudescent infection and 4 were re-infection. The PCR-corrected DHA–PPQ efficacy for P. falciparum was 97.9% (95% CI 92.7–99.7). Of the 80 cases of P. vivax that were followed up, 71 cases were completely cured and classified as ACPR (88.8%, 95% CI 79.7–94.7) and 9 cases showed recurrent infection at days 35 and 42, and classified as LTF. In Sumatra, of the 751 subjects screened, 35 vivax subjects enrolled, 34 completed the 42 day follow up. Thirty-three cases were completely cured and classified as ACPR (97.1%, 95% CI 84.7–99.9) and 1 recurrent infection was observed and classified as LTF. No delay in parasite clearance nor severe adverse reaction was observed. Analysis of the Pfk13 gene in P. falciparum cases from Papua revealed no mutations associated with artemisinin resistance in the 20 SNPs previously reported. Analysis of the Pfpm2 gene at day 0 and day of recurrence in recrudescent cases revealed the same single copy number, whereas 3 of the 4 re-infection cases carried 2–3 Pfpm2 gene copy numbers. Conclusion Treatment of falciparum and vivax malaria cases with DHA–PPQ showed a high efficacy and safety.

Context: Hyperglycemia causes diabetes mellitus (DM), abnormal metabolism, oxidative stress, and chronic complications such as impotence. Hyperglycemia causes testicular atrophy and stromal cell, seminiferous tubular damage, and spermatogenic cells. Bischofia javanica Blume is a plant that is used for the treatment of various chronic conditions and has traditionally by the people of Indonesia as a diabetes medicine. Aims: To determine the effect of B. javanica extract on the increase in the quality and quantity of sperm of hyperglycemic rats. Methods: The treatment groups consisted of; G0: negative control (-), G1: positive control (DM: alloxan induction + standard feed), G2-G4: DM + 300, 600 and 900 mg/kg BW of B. javanica leaves ethanol extract, respectively, and G5: DM + glibenclamide 0.5 mg/kg BW. Rats were dissected, and then the testes were taken to analyze sperm quantity and quality and immunohistochemistry. Results: There was a significant difference (p

Coaching for young people is an investment in the future for a nation, religion, church, and also the future of the world of education. Neglect for the formation of youth means sowing the seeds of destruction in the future. On the one hand, although giving attention and coaching to young people regularly if the content of the coaching material is not based on essence truth and based on Bible truth, this will also result in a misguided future in the nation, religion, church as well as in the world of education. The consequences of that mistake would have to be paid dearly in the future. Therefore it can be said that errors in understanding result in errors in practice. This book gives serious attention to this field by presenting Bible facts ranging from ethics, Christian education to the use of internet media among young people. Understanding the contents of this book will provide true insight on how to give attention and guidance to young people for a bright future Abstrak Gereja memberikan perhatian pada pendidikan anak dan diwujudkan dalam bentuk pembinaan kategorial anak, pra-remaja, remaja dan dewasa. Hal ini bertujuan agar anak bertumbuh dalam kerohanian yang baik dan benar dan lebih takut pada Tuhan daripada takut pada sesama maupun falsafah hidup dunia yang tidak sesuai dengan pengajaran Alkitab. Buku ini memberikan panduan yang praktis dan mudah dimengerti bagi siapa saja yang terlibat dalam pembinaan kaum muda baik di Gereja maupun komunitas-komunitas dengan basis kaum muda. Penulis Buku biasanya menulis dengan memakai banyak contoh kasus yang telah ada, kemudian menggali Alkitab yang sesuai dengan topik sedang dibahas (studi kasus biasanya sampai 5 kasus), kemudian memberikan pengajaran yang menjadi pokok perhatian penulis. Ada enam belas topik yang dipaparkan penulis dalam buku ini dimana semuanya sangat penting dalam pendidikan agama kristen untuk kategorial anak hingga dewasa. Buku ini cocok untuk pemimpin yang memberikan perhatian dan upayanya untuk membentuk anak menjadi pemimpin masa depan yang tangguh.

TRAINING OF OBJECTIVITY AND THE IMPORTANCE OF LEARNING IN PARENTING FOR CHILDREN. Family is a group consisting of individuals bound by marriage or blood relationship consisting of parents (father, mother) and children. In the family, the biggest role is parents. Parents have an obligation to educate, and raise children as well as possible which in the process involves parenting. In parenting, parents must pay attention to the elements of objectivity and learning, namely parents must be able to assess and pay attention to children according to their portions and their willingness to learn. This activity is carried out to support parents' knowledge about the objective and learning elements. The audience is the women of the RPTRA community as many as 47 people. Submission of objective and learning materials will be delivered through lecture teaching methods and also distributing pre-test and post-test forms. As a result, there were many variants of answers from the audience, and this activity increased their understanding of good parenting. This activity is still limited to the level of knowledge and understanding, there is still a need for more effective follow-up activities so that they can be applied in life.

Objective: This study aims to investigate the characteristics of androgen receptors (AR), estrogen receptor 1 (ER1) and estrogen receptor 2 (ER2) expression in dartos tissue of patients with congenital hypospadias, compared to normal penis. Material & Methods: We harvested 63 dartos tissue consisting of 53 congenital hypospadias that underwent urethroplasty (20 distal and 33 proximal) and 10 normal penis that underwent circumcision as controls from September 2017 to September 2018. The expressions of AR, ER1, and ER2 were measured using Quantitative Real-Time PCR (qPCR). All data were analyzed by Prism 7, and one-way ANOVA tests were used to compare gene expressions between the groups. Results: The mean age was 68.99 (± 45.5) and 65.6 (± 25.8) months in boys with and without hypospadias, respectively. The expression of mRNA AR was decreased in proximal (6.26 ± 2.30) and distal hypospadias (6.43 ± 2.22) compared to controls (9.69 ± 1.10), which were statistically significant (p=0.0001 and p

Citizens’ participation in e-government is imperative for the government as it implies citizens’ participation in public policy. Furthermore, how government strategies allocate resources to increase participation in e-government is essential to investigate. Nevertheless, scant literature debates how e-government can facilitate citizen participation as part of the government’s deliberative policy-making process. To fill the gap, this study uses social media, good governance, and trust to predict e-government participation and testing the hypothesis using PLS-SEM and fsQCA on 455 Indonesian participants who have experience with e-government. The results from SEM confirmed that trust in e-government is the principal predictor of achieving citizens’ participation. To achieve citizens’ trust in e-government, the government must consider perceived ease of use and usefulness as critical factors while spreading e-government-related information on social media. At the same time, transparency from the good governance aspect enhances citizens’ trust. The results of fsQCA equip theoretical and practical insights for the government to determine whether citizens have high or low levels of e-government participation. In achieving high e-government participation, trust, information quality, perceived ease of use, and perceived usefulness are necessary. Besides, low participation occurs when information about e-government is absent on social media and do not care about good governance. These findings will assist the government in comprehensively improving public services through social media and good governance.

This study aims to develop a multidimensional curriculum evaluation model (ECM) for the Independent Curriculum in Elementary Schools (SD). Independent Curriculum is a curriculum that allows teachers to design quality learning based on students’ needs and environment. It focuses on enhancing students’ character and competencies through the Pancasila student profile project. A comprehensive, systematic, and continuous evaluation model is required to ensure Independent Curriculum’s quality and relevance. The research method is R&D using the ADDIE model with five stages: analysis, design, development, implementation, and evaluation. The subjects are teachers, principals, supervisors, and curriculum experts. Data are collected through questionnaires, interviews, observations, and documentation. Data are analyzed quantitatively and qualitatively. The results show that ECM has six evaluation dimensions: context, input, process, product, impact, and meta-evaluation, which suit the Independent Curriculum’s characteristics in SD. ECM can evaluate various curriculum aspects: objectives, content, strategies, media, learning resources, assessment, learning outcomes, and curriculum impact. ECM also has a computer application program that simplifies the evaluation process and reporting. ECM receives positive feedback from the subjects and is valid, reliable, practical, and effective. The study concludes that ECM can improve Independent Curriculum quality in SD.

ABSTRACT During the COVID-19 pandemic era, the government has implemented a new strategy of health protocol called Adaptation of New Habits to prevent COVID -19 virus spread. By implementing such protocol, it is expected that health and economic sectors can be handled well. The research aims to discover the implementation of health protocol in Indonesia’s food and beverage business, and to analyze factors that support and hamper its implementation. This research was cross-sectional research with direct observation and brief interviews with 16 food and beverage business places. Observations and interviews were guided using a checklist derived from government policies set by the ministry of health and commerce then the data will be analyzed descriptively. This research shows that the implementation health protocol remained far from expectations. Moreover, business activity, management system, and the awareness of employers, employees, as well as consumers, became a critical key in health protocol implementation. Comprehending the dangers of COVID-19 and committing to comply with health protocols are imperatives to succeed in the health protocol implementation. Keywords: Adaptation of New Habits, Health Protocol of COVID-19 Pandemic, evaluating health protocols implementation

Context: Gallic acid and quercetin in sikkam leaves (Bischofia javanica) have scientific potential as antidiabetic agents. Quercetin suppresses hyperglycemia by inhibiting active glucose transport. Meanwhile, gallic acid acts as an antidiabetic is closely related to its antioxidant properties. Antioxidant compounds neutralize cells that experience oxidative stress by donating their hydrogen atoms. Aims: To analyze the degree of insulitis and insulin expression in the pancreatic cells of rats induced diabetes mellitus (DM) after giving B. javanica leaves extract. Methods: The treatment groups consisted of G0: negative control (-); G1: positive control (alloxan induction + standard feed); G2: alloxan induction + 300 mg/kg BW of B. javanica leaves ethanol extract; G3: alloxan induction + 600 mg/kg BW of B. javanica leaves ethanol extract; G4: alloxan induction + ethanol extract of B. javanica leaves 900 mg/kg BW and G5: alloxan induction + glibenclamide 4.5 mg/kg BW. At day 28, the rats were sacrificed, and the pancreatic tissue dissected. This was analyzed for degree of insulitis and insulin expression by anti-insulin antibodies using immunohistochemistry and hematoxylin-eosin. Results: There was a significant difference (p = 0.000) in insulin expression and insulitis degree. By the increase of B. javanica leaves dose, the insulin expression value also increased, and the degree of insulitis in Langerhans’ islets of DM rats was decreased. Islets of Langerhans in insulin production returned to normal after being given B. javanica ethanol extract 900 mg/kg BW like glibenclamide. Conclusions: Bischofia javanica ethanol extract increased insulin production and reduced the degree of insulitis in the islets of Langerhans histology. Further research is needed to determine the extent to which this extract protects from the sequelae of diabetes.

Context: Diabetes mellitus (DM) is a metabolic hyperglycemia disease caused by abnormalities in insulin secretion and the highest increase in diabetes sufferers that occurred in Southeast Asian countries, including Indonesia. The sikkam leaf (Bischofia javanica) ethanolic extract contains many secondary metabolites, and some of them are quercetin and gallic acid, which have the potential to be used as antidiabetic. Aims: To analyze apoptosis via cytochrome c in aortic tissue of DM after giving B. javanica leaves. Methods: The treatment group consisted of G0: Negative control, G1: Positive control (alloxan induction + standard feed), G2: Alloxan induction + 300 mg/kg BW of B. javanica leaves ethanol extract, G3: Alloxan induction + 600 mg/kg BW of B. javanica leaves ethanol extract, G4: Induction of alloxan + ethanol extract of B. javanica leaves 900 mg/kg BW and G5: Induction of alloxan + glibenclamide 0.5 mg/kg BW. Fourteen days later, the rats were dissected, and the aortic tissue was analyzed for apoptosis by tunnel assay and cytochrome c by immunohistochemistry. Results: There was a statistically significant difference (p

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This study presents a comprehensive strategy for PT Sulzer Indonesia to expand its presence in the >400MW Steam Turbine market in Indonesia. Employing a mixed-method approach, the research combines qualitative interviews with six industry experts and quantitative Analytic Hierarchy Process (AHP) analysis to identify key success factors and prioritize Original Equipment Manufacturers (OEMs) for strategic marketing focus. The findings highlight the critical importance of market viability, particularly market accessibility, along with competitive advantages such as technological fit and strong engineering capabilities. The AHP analysis reveals Mitsubishi Hitachi Power Systems, Toshiba Energy Systems and Solutions, and GE Vernova as the top-ranked OEMs as potential focused market. A 12-month implementation plan is proposed, structured into six phases: preparation and assessment, planning and design, initial implementation, expansion, and refinement, further implementation, and evaluation and optimization. This plan emphasizes continuous learning, adaptability, and strategic alignment, drawing on established management theories and industry best practices. The study concludes that by focusing on these prioritized OEMs and following the proposed implementation plan, PT Sulzer Indonesia can effectively capitalize on the growing opportunities in the >400MW Steam Turbine market, leveraging its strengths while addressing challenges in resource alignment and market penetration. This research provides PT Sulzer Indonesia with a theoretically grounded and practically applicable roadmap for achieving sustainable growth and competitive advantage in this critical market segment. [ABSTRACT FROM AUTHOR]

As the urgency to reduce carbon emission increases, seagrass ecosystems have recently received attention due to their capacity to take up and store high amounts of carbon. Protection of this ecosystem is key to increase resilience to climate change. However, in some of the Marine Protected Areas (MPAs), seagrass ecosystems are still under threat. This study aims to investigate the current condition of seagrass ecosystems and compare it to the previous study before MPA was established in the Berau coastal water. SeagrassWatch method was used to measure seagrass community structure. Other proxies were also used to explain factors affecting seagrass condition such as total suspended solid (TSS) and sedimentary stable isotopes to identify the source of organic carbon. The percentage cover of seagrass in this study were categorized as not healthy (<29-59.9%), which was statistically related to TSS. The higher TSS resulted in the lower seagrass cover, as observed in the Rabu Rabu island located adjacent to mainland. Changes in seagrass composition were observed, including the emergence of larger species of E. acoroides and T. hemprichii in the islands located adjacent to mainland. The spatial and temporal changes of seagrass ecosystems observed in Berau MPA should be taken into consideration that conservation on seagrass ecosystems needs to be prioritized by improving the MPA function to avoid further loss of carbon from seagrass ecosystems. [ABSTRACT FROM AUTHOR]

E-commerce application usability refers to the design and functional aspects that facilitate user interaction and goal achievement. Well-designed usability of e-commerce applications will lead to usage continuance by users. Therefore, this study tries to identify usability factors and measure the effect of usability on usage continuance. Based on previous studies, the variables hypothesized to be the factors that define usability are learnability, efficiency, memorability, accuracy, emotion, and utility. Utility is a variable that represents the functional aspects of usability. It is described in more detail into information search, interface display, and transaction. Furthermore, this study also examined the relationship between usability, usage continuance, satisfaction, and usefulness. This study’s hypotheses were evaluated using 242 survey responses from e-commerce application users. Structural equation modeling, or SEM, was applied to process the empirical data. Memorability, accuracy, efficiency, and utility were found to be able to describe the usability of e-commerce applications well. This proved that functional quality is also an essential part of usability. Usability was found to influence usage continuance. [ABSTRACT FROM AUTHOR]