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This work explores six newly designed compounds obtained by several substitutions in 2,5-di(2-thienyl) pyrrole molecule. For this series of compounds, the electronic and optical properties were investigated using density functional theory and time-dependent density functional theory (TD-DFT). The new compounds were characterized by calculating the chemical parameters that correlated with their optical and electrical properties. The lowest unoccupied molecular orbital (LUMO) and the highest occupied molecular orbital (HOMO) energies are calculated using the B3LYP functional with the 6-311G (d, p) basis set. The most low-lying energy level of the LUMO was found for Perr-NO2, indicating its effective electron injection capabilities and oxidation resistance. The HOMO and LUMO distributions of Perr-Cl and Perr-NO2 displayed a remarkable complementarity throughout each component of the two compounds, indicating an effective intermolecular charge transfer. The molecular electrostatic potential analysis demonstrated that the proposed compounds have a broad distribution of electrophilic and nucleophilic sites, which predict a high degree of chemical reactivity. The electron density analysis at the bonding and anti-bonding sites of the title compounds was performed using the electron localization function and local orbital locator techniques. Non-covalent interaction analysis using the reduced density gradient approach classified all types of interaction: repulsive, weak, and attractive interactions within compound fragments. All compounds exhibited a robust repulsive interaction, as proved by the red spikes at 0.038 a.u. The ultraviolet/visible (UV/vis) spectrum was obtained by TD-DFT using CAM-B3LYP models in conjunction with 6-311G (d, p) basis set and methanol as a solvent, the absorption bands were found within the UV range, and the maximum wavelength showed red-shifted increases. These compounds could serve as a base material for developing selective gas sensors with considerable UV/vis absorption (180–400 nm). According to the research results, the designed compounds are good candidates for use as precursors in polymer designs for optoelectronic and sensor applications due to their high electrical conductivity and photochemical properties.

The oral microbiome potentially wields significant influence in the development of cancer. Within the human oral cavity, an impressive diversity of more than 700 bacterial species resides, making it the second most varied microbiome in the body. This finely balanced oral microbiome ecosystem is vital for sustaining oral health. However, disruptions in this equilibrium, often brought about by dietary habits and inadequate oral hygiene, can result in various oral ailments like periodontitis, cavities, gingivitis, and even oral cancer. There is compelling evidence that the oral microbiome is linked to several types of cancer, including oral, pancreatic, colorectal, lung, gastric, and head and neck cancers. This review discussed the critical connections between cancer and members of the human oral microbiota. Extensive searches were conducted across the Web of Science, Scopus, and PubMed databases to provide an up-to-date overview of our understanding of the oral microbiota’s role in various human cancers. By understanding the possible microbial origins of carcinogenesis, healthcare professionals can diagnose neoplastic diseases earlier and design treatments accordingly.

In this study, we introduced a mathematical model mimicking as much as possible the evolutions and interactions between glioma and lactate in the brain, in order to test different therapies and administration protocols. We simulated both glioma cell density evolution and lactate concentration, and considered two therapies: chemotherapy and a treatment targeting lactate production. Three different protocols for administrating the therapies were tested. We compared the efficiency of the combined therapies, depending on the administration protocols and the dosage of the drugs, in order to evaluate the importance of controlling lactate production. Results show that the use of an agent to reduce lactate concentration permits one to significantly reduce the dose of the chemotherapeutic drug.

Abstract The fate of cadmium at the Muharram Aisha wastewater treatment plant in Karbala governorate, Iraq was studied using the TOXCHEM model. Cadmium, a known carcinogen, and is considered one of the most dangerous heavy metals and high concentrations, greater than permissible limits, were found in the treated wastewater. The plant operates using an activated sludge system and this was modeled via TOXCHEM with a sensitivity analysis carried out on the extended aeration system. Prior to analysis, the model was calibrated and validated for cadmium, with the adjustments leading to a mean square error (RMSE) and correlation coefficient (R) of 0.0001 and 0.81, respectively. The mass balance of cadmium in the Muharram Aisha treatment plant was found to be 4832.44 g/day (37.1726%) in the treated wastewater and 8164.52 g/day (62.804%) in the sludge, which indicated that the mix liquor suspended solid (MLSS) was the most sensitive factor. The sensitivity to cadmium was analyzed via MLSS in the extended aeration system and the results o indicated that the higher the MLSS concentration (mg/L), the greater the removal of cadmium in the treated wastewater. It was found that increasing the MLSS through a biological treatment method reduced the concentration of cadmium without the need for additional of any (potentially harmful) chemical treatments. The plant was subsequently operated for a period of 5 months with the MLSS increased from 1500 to 4500 mg/L, and this reduced the concentration of cadmium in the wastewater from 0.36 to 0.01 mg/L as a consequence. This research demonstrates how the novel application of TOXCHEM can be a useful tool in the reduction of heavy metal contamination in the environment.

Background: Fournier’s gangrene represents a life-threatening necrotising infection affecting the perineal region, while hidradenitis suppurativa is characterised by a chronic inflammatory skin condition. The simultaneous occurrence of both conditions is exceedingly rare. Case description: A 42-year-old female with a documented history of severe untreated hidradenitis suppurativa presented for shortness of breath, fever and lethargy, along with extensive wounds and skin breakdown involving the left axilla, perineum, lower back, lumbosacral region and bilateral gluteal areas, extending to the perineum. Upon presentation, the patient was in a state of septic shock, and a diagnosis of actively manifesting Fournier’s gangrene was established at the site of the pre-existing hidradenitis suppurativa lesions. Despite the implementation of an aggressive multidisciplinary approach incorporating surgical interventions, antibiotic therapy and intensive care measures, the patient’s condition deteriorated, culminating in septic shock, multi-organ failure and eventual demise. In this report, we discuss both clinical entities, their similarities and differences, and the possible mechanisms by which they may have co-occurred. Conclusion: The co-existence of hidradenitis suppurativa and Fournier’s gangrene poses unique challenges, given the rapid progression of Fournier’s gangrene within the context of hidradenitis suppurativa, potentially suggesting the latter as a predisposing factor. This case underscores the importance of vigilant screening and management of hidradenitis suppurativa.

Ayman Mohamed El-Ashry,1 Mohamed Hussein Ramadan Atta,1 Samira Ahmed Alsenany,2 Sally Mohammed Farghaly Abdelaliem,3 Mahmoud Abdelwahab Khedr1 1Department of Psychiatric and Mental Health Nursing, Faculty of Nursing, Alexandria University, Alexandria, Egypt; 2Department of Community Health Nursing, College of Nursing, Princess Nourah bint Abdulrahman University, Riyadh, 11671, Saudi Arabia; 3Department of Nursing Management and Education, College of Nursing, Princess Nourah bint Abdulrahman University, Riyadh, 11671, Saudi ArabiaCorrespondence: Sally Mohammed Farghaly Abdelaliem, Alyasmeen 153, Riyadh, 13326, Saudi Arabia, Tel +966550773686, Email smfarghaly@pnu.edu.saBackground: Distress tolerance skills have the potential to decrease problematic internet use and improve psychological wellbeing by cognitive reframing and goal-oriented problem-solving.Aim: To assess the impact of distress tolerance training on problematic internet use and psychological wellbeing among university nursing students.Methods: A randomized control trial used at the faculty of nursing using simple random sampling method. Tools: Distress Tolerance Scale, problematic internet use questionnaire, and Ryff psychological wellbeing scale. Data were collected from 60 nursing students over a period of 4 months.Results: Distress tolerance level was increased among study group from 20.75± 14.29 to 72.75± 24.09 and sustained for 3 months to 62.44 ± 20.77 with statistically significant (f=7.090, p=0.006) and large effect size 0.75. When compared to no change among the control group as mean scare start by 22.35± 14.29 to 23.44± 16.09 and after 3 months to 21.75± 17.44 with insignificant difference (f=0.454, p=0.574). The mean score of problematic internet use shows highly statistically significant decrement in the study group between three period of time (pretest= 62.93, immediately post= 52.13, and post 3 months=52.70) with large effect size 0.78 (f=95.029, p< 0.001), in compared to control group that showed insignificant no changes (pretest= 64.0± 14.54, immediately post= 63.13± 12.87, and post 3 months=63.53± 11.36) with (f=1.012, p=0.332). In addition, the total mean score of psychological well-being was increased immediately after therapy and later for three months of therapy (pretest= 128.47, immediately post=148.77, and post 3 months= 153.60) with highly statistically significant (f=41.197, p< 0.001) with effect size 0.85, compared to no change among control group (pretest=125.97± 32.58, immediately post= 126.23± 30.86, and post 3 months=126.43± 29.78) with (f=0.208, p=0.698).Conclusion: Efficacy of distress tolerance skills intervention had been proven in altering poor psychological wellbeing among students with problematic internet use. It helps students to learn new skills and use more adaptive strategies to overcome distress tolerance difficulties.Keywords: distress tolerance training, problematic internet use, psychological wellbeing, nursing students

في هذا البحث تم التعرف على تأثير استخدام منصات التواصل الاجتماعي في تكوين صور العلامة التجارية وبناء الثقة والولاء لدى الزبائن في السوق العراقي. إذ اعتمد البحث على المنهج الوصفي التحليلي من خلال تقديم استبانة ووزعت على 100 شخص عشوائياً من بينهم مستخدمي منصات التواصل الاجتماعي والمسوقين الإلكترونين وعدد من مديري الشركات التي تستخدم التسويق الرقمي، من خلال فحص وتحليل إجابات المشاركين عن تفاعل المستخدمين وجودة المحتوى على هذه المنصات، نشير إلى أن الاستجابة الفعّالة والإيجابية يمكن أن تعزز بشكل كبير فهم العلامة التجارية وثقة الزبائن، مما يسهم في بناء علاقات قائمة على الولاء. بناءً على الفرضيات والتوصيات العملية، تظهر الدراسة أهمية تكامل استراتيجيات التسويق الرقمي عبر منصات التواصل الاجتماعي لتحقيق أهداف تسويقية فعّالة وتعزيز مكانة العلامة التجارية في أذهان الجمهور العراق، ومن هنا يمكن لهذا البحث أن يسهم مكن للبحث أن يساهم في تطوير استراتيجيات التسويق الرقمي وإدارة العلامات التجارية، خاصة في سياق استخدام منصات التواصل الاجتماعي، ويمكن أن يكون ذا أهمية خاصة للشركات والمسوقين العاملين في سوق العراق.

Coffee is the most essential drink today, aside from water, the high consumption of coffee and the byproducts of its soluble industries such as spent coffee grounds can have a negative effect on the environment as a source of toxic organic compounds. Therefore, caffeine removal from the spent coffee ground can be applied as a method to limit the effect of its production on the environment. The aim of this study is to determine the kinetics and thermodynamics parameters and develop models for both processes based on the process parameters by using traditional solid-liquid extraction and Ultrasound-assisted extraction methods. The processes were performed at a temperature range of 25 to 55 °C for traditional and ultrasound baths, and experimental time ranged from 5- 60 min. The results demonstrated that under the above conditions, the extraction process applies to the pseudo-first-order reaction, where the rate constant K value increases with temperature. The transition state parameters were also discussed where these parameters indicated that the system of the process exhibited an activated complex formation state resulting in a thermodynamically unfavorable process, and the thermodynamic parameters at the equilibrium state were also evaluated in terms of the obtained yield percentage. The results also showed that the ultrasound-assisted bath process showed a spontaneous behavior at temperatures of 45 °C and 55 °C with D°G of -1192.9703 and - 2725.25 J/mole. On the other hand, for the traditional method, the extraction process was approaching a spontaneous behavior with the temperature increasing where at 25 °C the D°G value was 10379.944 J and at a temperature of 55 °C it reached 8004.26 J/mole.

Background: Colorectal cancer ranks second as a cause of cancer deaths. Mutations in the adenomatous polyposis coli (APC) gene, especially in exon 16, could contribute to colorectal carcinoma development. This study explored the correlations between APC gene exon 16 variations/expression and colorectal carcinoma progression. Methods: In a case-control study, blood samples from 150 colorectal carcinoma patients and 50 healthy volunteers were analyzed by PCR and sequencing for APC exon 16 variations. The APC protein expression on tissue samples was evaluated by immunohistochemistry and statistical analyses were used to examine clinicopathological correlations. Results: The sequencing analysis revealed a mutation in exon 16 of the APC gene (rs459552) in 36 % of colorectal cancer cases while absent in all non-cancer controls. Subgroup analysis by tumor grade showed higher prevalence of mutant allele in Grade II and Grade III cases, with frequencies reaching 60.0 % and 69.2 %, respectively, compared to a substantially lower prevalence of 29.4 % in Grade I patients. Immunohistochemistry showed no significant correlation between this mutation and APC expression. APC positivity proportions were 25.5 % in Grade I tumors (n = 26/102) versus 17.1 % in Grade II (n = 6/35) and 46.2 % in Grade III (n = 6/13), showing a non-significant trend of reduced positivity in higher grade tumors (p>0.05). Conclusions: The frequency of APC exon 16 mutation (rs459552) rose significantly with increasing tumor grade. Similarly, although not statistically significant, the percentage of APC positive staining increased with poorer tumor differentiation, rather than declining. Therefore, the APC exon 16 mutation and expression analysis provides insights into colorectal cancer progression, with the rs459552 mutation correlating with grade and may promoting aggression.

Metal-organic frameworks (MOFs) are promising materials offering exceptional performance across a myriad of applications, attributable to their remarkable physicochemical properties such as regular porosity, crystalline structure, and tailored functional groups. Despite their potential, there is a lack of dedicated reviews that focus on key physicochemical characterizations of MOFs for the beginners and new researchers in the field. This review is written based on our expertise in the synthesis and characterization of MOFs, specifically to provide a right direction for the researcher who is a beginner in this area. In this way, experimental errors can be reduced, and wastage of time and chemicals can be avoided when new researchers conduct a study. In this article, this topic is critically analyzed, and findings and conclusions are presented. We reviewed three well-known XRD techniques, including PXRD, single crystal XRD, and SAXS, which were used for XRD analysis depending on the crystal size and the quality of crystal morphology. The TGA profile was an effective factor for evaluating the quality of the activation process and for ensuring the successful investigation for other characterizations. The BET and pore size were significantly affected by the activation process and selective benzene chain cross-linkers. FTIR is a prominent method that is used to investigate the functional groups on pore surfaces, and this method is successfully used to evaluate the activation process, characterize functionalized MOFs, and estimate their applications. The most significant methods of characterization include the X-ray diffraction, which is utilized for structural identification, and thermogravimetric analysis (TGA), which is used for exploring thermal decomposition. It is important to note that the thermal stability of MOFs is influenced by two main factors: the metal-ligand interaction and the type of functional groups attached to the organic ligand. The textural properties of the MOFs, on the other hand, can be scrutinized through nitrogen adsorption-desorption isotherms experiments at 77 K. However, for smaller pore size, the Argon adsorption-desorption isotherm at 87.3 K is preferred. Furthermore, the CO2 adsorption isotherm at 273 K can be used to measure ultra-micropore sizes and sizes lower than these, which cannot be measured by using the N2 adsorption-desorption isotherm at 77 K. The highest BET was observed in high-valence MOFs that are constructed based on the metal-oxo cluster, which has an excellent ability to control their textural properties. It was found that the synthesis procedure (including the choice of solvent, cross-linker, secondary metal, surface functional groups, and temperature), activation method, and pressure significantly impact the surface area of the MOF and, by extension, its structural integrity. Additionally, Fourier-transform infrared spectroscopy plays a crucial role in identifying active MOF functional groups. Understanding these physicochemical properties and utilizing relevant characterization techniques will enable more precise MOF selection for specific applications.

Abstract Background Gastroenteropancreatic Neuroendocrine tumors (GEP-NET) are rare neoplasms with limited reported data from the Middle East. Our study aims to report the clinicopathological feature, treatment patterns, and survival outcomes of patients with GEP-NET from our part of the world. Methods Medical records of patients diagnosed with GEP-NET between January 2011 and December 2016 at a single center in Saudi Arabia were reviewed retrospectively, and complete clinicopathological and treatment data were collected. Patients’ survival was estimated by the Kaplan–Meier method. Results A total of 72 patients were identified with a median age of 51 years (range 27–82) and male-to-female ratio of (1.1). The most common tumor location was the pancreas (29.1%), followed by small bowel (25%), stomach (12.5%), rectum (8.3%), colon (8.3%), and appendix (6.9%). Forty-one patients (57%) had well-differentiated grade (G)1, 21 (29%) had G2, and 4 (6%) had G3. In five patients, the pathology was neuroendocrine carcinoma and in one it could not be classified. 54.2% of the patients were metastatic at diagnosis. Forty-two patients underwent surgical resection as primary management while 26 underwent systemic therapy, three patients were put on active surveillance, and one was treated endoscopically with polypectomy. The 5-year overall survival and progression-free survivals were 77.2% and 49%, respectively, for the whole group. Patients with G1 and 2 disease, lower Ki-67 index, and surgically treated as primary management had significantly better survival outcomes. Conclusion Our study suggests that the most common tumor locations are similar to western reported data. However, there seems to be a higher incidence of metastatic disease at presentation than in the rest of the world.

This in vitro study assessed the effect of different primers on the shear bond strength (SBS) and adhesive remnant index (ARI) of orthodontic brackets bonded to reinforced polyetheretherketone (PEEK) substrate. A total of 40 specimens were randomly distributed to two groups based on the primer used for orthodontic bonding: group 1 (control)—Transbond XT adhesive with Visio.link primer and group 2 (test)—orthodontic adhesive (Transbond XT) with traditional orthodontic primer. After bonding, specimens were thermocycled followed by SBS testing and ARI scoring of debonded specimens. Data were analyzed using the unpaired independent t-test and the Chi-square test. Group 1 specimens showed significantly higher SBS values (21.38 ± 1.48 MPa) compared to group 2 specimens (18.63 ± 1.29 MPa) (p < 0.0001). Adhesive remnant index scores showed no significant variations in bond failure modes and distributions between groups. The SBS obtained by the tested primers exceeded the clinically recommended value. Consequently, there is a comparable clinical application for both tested primers in orthodontic bonding, especially the traditional orthodontic primer, where the availability of Visio.link in clinical practice is not ensured.

Water contamination is a pressing global concern, especially regarding the presence of nitrate ions. This research focuses on addressing this issue by developing an effective adsorbent for removing nitrate ions from aqueous solutions. two adsorbents Chitosan-Zeolite-Zirconium (Cs-Ze-Zr composite beads and Chitosan-Bentonite-Zirconium Cs-Bn-Zr composite beads were prepared. The study involved continuous experimentation using a fixed bed column with varying bed heights (1.5 and 3 cm) and inlet flow rates (1 and 3 ml/min). The results showed that the breakthrough time increased with higher bed heights for both Cs-Ze-Zr and Cs-Bn-Zr composite beads. Conversely, an increase in flow rate led to a decrease in breakthrough time. Notably, Cs-Ze-Zr and Cs-Bn-Zr demonstrated impressive removal efficiencies, reaching 87.23% and 92.02%, respectively. The optimal conditions for peak performance were found to be an inlet flow rate of 1 ml/min, a bed height of 3 cm, and initial concentrations of 400 mg/L and 600 mg/L for Cs-Ze-Zr and Cs-Bn-Zr, respectively.

Nonholonomic wheeled mobile robots are considered to be multi-input multi-output systems that are performed in varying environments. This work presents the trajectory tracking control of a nonholonomic wheeled mobile robot (WMR). The Kinematic and the dynamic models of the robot were derived. A new hybrid controller was designed, which consisted of two controllers based on an optimization algorithm to solve the trajectory tracking problem. The first controller is the Fractional order PID controller, which is based on the kinematic model and has been applied to control the linear and the angular robot velocities, while the second controller is a linear quadratic regulator (LQR) and is based on the dynamic model used to control the motors' torques. A new, improved version of grey wolf optimization wasadopted to tune the parameters of the hybrid controller. The main goals of this improvement are rapid convergence towards a solution, reducing the effect of the wolves' random motion, and balancing exploitation and exploration processes. MATLAB software was used to simulate the results under an S-shape trajectory and to evaluate the robustness and performance of the proposed control unit. The simulation results demonstrated the adopted control system's activity and efficiency based on the mean square error (MSE) between the desired and actual trajectory. The values of MSE of trajectory in the X and Y directions and the orientation are [6.589*10-4(m) 8.421*10-5(m) 0.00401(rad)]T . Also, the adopted control system can generate smooth values of the control input signals without sharp spikes. The performance of the presented control system has been verified and compared with the results obtained from the other two control systems, and the simulation results have offered the superiority and effectiveness of the hybrid controller of this work.

This research examines the amalgamation of Circular Economy concepts with Lean Six Sigma approaches to enhance manufacturing operations, emphasizing waste minimization, resource efficiency, and economic performance. The study assesses the influence of Lean Six Sigma on production efficiency and environmental sustainability via empirical analysis and process optimization methodologies. Conventional manufacturing procedures, including machining, milling, and grinding, were assessed for resource utilization and waste production, revealing that Lean Six Sigma methodologies markedly decreased material waste, especially in milling operations, where waste was curtailed by 20%. Advanced precision techniques, including CNC and laser cutting, were evaluated for their efficiency, with CNC cutting realizing a 15% decrease in energy usage and a 30% enhancement in material utilization. Laser cutting exhibited improved accuracy, resulting in a 35% decrease in rework and scrap. The economic study indicated that the application of Lean Six Sigma in CNC operations resulted in a 25% reduction in operating expenses over time, albeit greater initial expenditures. These results provide significant insights into the enhancement of industrial efficiency and the promotion of sustainable production practices via the integration of Circular Economy concepts with Lean Six Sigma methodologies. Keywords: Circular Economy, Precision Manufacturing, Comparative Analysis, Tool Life, Economic Implications.

This study investigates climate mitigation solutions in urban planning using a thorough scenario analysis methodology. This research seeks to find actionable insights for sustainable development by evaluating production indicators, resource use, process efficiency, and cost management in urban settings. The investigation examines a four-month period, uncovering notable trends in resource distribution and Urban Planning. February had the greatest implementation of sustainable measures, corresponding with a decrease in environmental effect indices. The research identifies an ideal resource utilization rate of eighty percent for urban infrastructure, effectively reconciling operational requirements with financial limitations. The research reveals that the planning and implementation stages are often efficient, however it underscores significant prospects for improvement in community participation and policy integration. This study highlights the need of integrating urban development with climate objectives, directing stakeholders towards comprehensive policies that promote enduring sustainability and resilience in urban ecosystems.

Background: Transcatheter aortic valve replacement (TAVR) has become the dominant treatment for aortic valve disease. While TAVR safety has improved over time, concern remains over the occurrence of cerebrovascular accidents (CVA) secondary to device placement, which is associated with increased morbidity and mortality. The Sentinel Cerebral Protection System (CPS) was developed to reduce the risk of embolic strokes associated with debris produced during TAVR. Studies evaluating Sentinel CPS efficacy have produced conflicting results, and there is little understanding of which patients are selected for device placement in “real-world” settings. With no existing guidelines on device use, the purpose of this study was to describe and compare the characteristics of patients who receive CPS with those who do not in a “real-world” setting of consecutive TAVR patients and evaluate its impact on postoperative complications, namely stroke. Methods: This was a single-center, retrospective study of all patients undergoing TAVR between July 1, 2019, and December 31, 2020. Patient demographics, baseline, and perioperative characteristics were collected prospectively using the Society of Thoracic Surgeons (STS)/American College of Cardiology (ACC) Transcatheter Valve Therapy (TVT) Registry and our institution’s TAVR database for analysis. Postoperative outcomes were assessed using primary endpoints of in-hospital/30-day stroke and the composite of death, stroke, and bleeding/vascular events at one-year. To adjust for baseline differences, a propensity score was developed including all factors that were different between groups, and Multivariate Cox Regression analysis was used to control for these differences. Patient follow-up was 97% complete at 12 months with 100% echocardiographic follow-up. Results: A total of 242 consecutive patients (57.9% male) were analyzed, with a mean age of 79.9 ± 9 years. Of these patients, 134 (55.4%) received the Sentinel CPS and 108 (44.6%) did not. Sentinel CPS patients were more likely to be male, not on dialysis, without prior CVA or pacemaker, had less severe chronic lung disease, and were lower operative risk compared to concurrent non-CPS patients. CPS patients were also found to have higher hemoglobin and albumin levels, lower creatinine, and were less likely to be on immunosuppressant therapy. The incidence of in-hospital/30-day stroke after TAVR did not differ between CPS and non-CPS patients (0.0% vs. 1.9%; p = 0.198). Unadjusted analyses at one-year showed a lower occurrence of the composite endpoint in CPS patients compared non-CPS patients (8.3% vs. 17.0%; p = 0.034). After adjustment, the hazard ratio (Adj HR) for the CPS group was no longer significantly associated with a lower composite endpoint (Adj HR = 0.609, 95% CI 0.244–1.523; p = 0.289). Both unadjusted (p = 0.233) and adjusted (p = 0.132) analyses showed no difference in the incidence of stroke at one-year. Conclusions: Our study demonstrates that in a “real-world” setting, the Sentinel CPS device is more likely to be used in healthier and less complex patients. In analyses adjusted for illness severity and patient complexity, CPS use did not have a significant effect on the incidence of in-hospital/30-day stroke or the composite endpoint of death, stroke, and bleeding/vascular events at one-year.

إنَّ معرفة أطوار الجنين ومراحل تخلّقه ونشأته والاطلاع عليها لها فوائد كبيرة وعظيمة في تشخيص فترات ومدد تلك الأطوار والمراحل العمرية وبيان صفاتها، للحفاظ عليه وتوفير الحماية له والمواظبة على رعايته ورعاية الأم التي تحمله وظروفها الحساسة التي تمر بها وخصوصاً في وقت الحمل ومن تلك الفوائد أيضاً أنه لا سامح الله في حالة إسقاطه وإجهاضه يمكن للمشرع من تحديد وترتّب القيمة المادية والمعنوية على ذلك وطبقاً للطور والمرحلة التي أجهز عليه كما هو الساري والمعمول به عند بعض متخصصي الفقه والقانون، وهذه الدراسة محاولة وإطلالة مختصرة لبيان تلك الأطوار والمراحل في الشريعة والطب ومقارنتها نسأل الله العظيم إن يجعلها في سبيله وإن يعم فائدتها إنه ولي النعم والكرم.

We herein present the case of a 79-year-old female patient who presents with a single asymptomatic pulmonary nodule, melanocytic in nature, later identified as a remote secondary lesion of a primary cutaneous melanoma that was resected 22 years before presentation. Although quite atypical, the patient underwent resection of the affected pulmonary lobe; follow-up imaging did not reveal any local or distant recurrences.

Abstract: Finding a reliable machines condition monitoring technique has been attracted many researchers to avoid the sudden failure in machines and the unexpected consequences. This work proposes a combined fault diagnosis methodology of air compressors using frequency-based features and distance metric-based classification. The analyzed experimental datasets contain one healthy condition and seven different fault conditions. Features are extracted from the frequency spectrum, then the best feature sets are selected using MRMR algorithm. Eventually the classification is conducted using a distance metric classifier. The results demonstrated the automatic classification can reach 99% correct classification rate. The effect of selected feature set size, training sample size on the classification accuracy is also investigated. From the results, this method of analysis can be used efficiently for early detection of faults with very great accuracy.

يهدف البحث لبيان تأثير كفاءة القيادة (مقدرتها) في إدارة مراحل مشاريع تكنولوجيا المعلومات المُمثلة بـ: (مرحلة البدء، مرحلة التخطيط، مرحلة التنفيذ، مرحلة الرقابة والمتابعة، مرحلة الإنهاء-الإغلاق)، وجاءَ البحث لِمعالجة مشكِلة التلكُؤ الذي تُعاني بَعض مَشاريع IT التي أطلقتها شركة آسياسيل للاتصالات النقالة في العراق في جوانب تحقيق الأهداف، السؤال الرئيسْ لِمشكلة البحثْ ما هو دور كفاءة القيادة في مَراحل ادارة مَشاريع تكنولوجيا المَعلومات في شركة آسياسيل للاتصالات، تَمثل ميدانْ البحثْ في شرِكة آسياسيل للاتِصالات الَنقالة العامِلة في العراقْ، فيما تَضمن مُجتمع البحثْ جَميع العاملينْ في مَشاريع تكنولوجيا المَعلومات والبالِغ عدَدهم (457)، وتَم استِخدام أُسلوب الحصرْ الشامِل في تحديدْ عَينة البحثْ عِبر توزيع استمارة الاستبانة (أداة البحث الرئيسة) إلكترونياً على جميعهم، تم استلام (388) استبانة. اعتمد البث للمنهج الوصفي التحليلي بوصفه المنهج الملائم لأهداف البحث، إذ تم تحليل بيانات الجانب الميداني التي تمّ تحصيلها باستخدام استمارة استبانة أعدت لهذا الغرض، باستخدام البرمجة الإحصائية الجاهزة (SPSS, V. 25) وبرنامج AMOS, V. 25))، أهم نتيجة للبحث أن هناك تأثير متغير الكفاءة على مراحل ادارة المشاريع على نحو كلي، مما يؤشر أن تمتع القائد بالكفاءة المطلوبة من شأنه ضمان نجاح مراحل المشروع اجمالاً، وبالتالي الحاجة للكفاءة لا تقتصر على مرحلة معينة بل هي ضرورية لكل مراحل المشروع، وكذلك البنائية تأثير كفاءة القائد على نحو معنوي أكبر في مرحلة التنفيذ منه على بقية المراحل، مما يؤشر بأن عملية التنفيذ قد تواجه الكثير من المعوقات على خلاف ما هو متوقع وخصوصاً في البيئة العراقية المتغيرة باستمرار، مما يستدعي تمتع القائد بالكفاءة اللازمة لمواجهة هذه المعوقات. أهم توصية: العمل على نشر فلسفة الكفاءة لدى قيادات المنظمة المبحوثة وبيان مدى اهميتها في نجاح المشاريع التكنولوجيا، وذلك من خلال الدورات التدريبية المكثفة مع الاستعانة بتجارب المنظمات الناجحة والتي تمتلك قيادات على درجة عالية من الكفاءة، وذلك العمل على تكوين توازن منطقي من حيث الاستفادة من مميزات القيادة الكفؤة في كل مرحلة من مَراحل إِدارَة مَشاريع تكنولوجيا المعلومات، عبر بيان أهمية كل مرحلة على النحو الذي يشجع استثمار طاقات القيادة الكفوءة.

Article accepted. The article will be published here soon. Pending final quality checks.

Effective treatment for heart failure with preserved ejection fraction (HFpEF) is an unmet need in cardiovascular medicine. The pathophysiological drivers of HFpEF are complex, differing depending on phenotype, making a one-size-fits-all treatment approach unlikely. Remarkably, sodium–glucose cotransporter 2 inhibitors (SGLT2is) may be the first drug class to improve cardiovascular outcomes in HFpEF. Randomised controlled trials suggest a benefit in mortality, and demonstrate decreased hospitalisations and improvement in functional status. Limitations in trials exist, either due to small sample sizes, differing results between trials or decreased efficacy at higher ejection fractions. SGLT2is may provide a class effect by targeting various pathophysiological HFpEF mechanisms. Inhibition of SGLT2 and Na+/H+ exchanger 3 in the kidney promotes glycosuria, osmotic diuresis and natriuresis. The glucose deprivation activates sirtuins – protecting against oxidation and beneficially regulating metabolism. SGLT2is reduce excess epicardial adipose tissue and its deleterious adipokines. Na+/H+ exchanger 1 inhibition in the heart and lungs reduces sodium-induced calcium overload and pulmonary hypertension, respectively.

Immunological phenomena have been described in infections such as infective endocarditis. However, none has been reported in the context of Babesiosis.Babesiosis is a tick-borne illness caused by the protozoa of the genus Babesia and causes infections that range from asymptomatic to severe and sometimes are fatal. This report presents the first case of ANCA/ANA positive severe babesiosis in an asplenic patient treated with repeated red blood cell exchange transfusion.

We herein present the case presenting to our facility complaining of a fever of two months duration, who underwent dental procedure. Patient was diagnosed with infective endocarditis secondary to an uncommon bacteria: Gemella haemolysans. Patient was found to have concomitant severe mitral valve regurgitation. Our patient did not have any comorbidity or risk factor beside his dental procedure. Our patient received intravenous antibiotic therapy for six weeks and was scheduled for mitral valve replacement.

اجري هذا البحث بهدف رصد وقياس ابعاد السياسة الإعلامية في القنوات الفضائية الموجهة من وجهة نظر القائم بالاتصال، ويصنف هذا البحث من ضمن الدراسات الوصفية، إذ استعان الباحث بالمنهج المسحي للإجابة عن التساؤلات التي تمت صياغتها في ضوء مشكلة البحث المتمثلة بالتساؤل الرئيس ما أبعاد السياسة الإعلامية في القنوات الفضائية الموجهة ؟ . ولتحقيق أهداف الدراسة استخدم الباحث أداتي: الاستبانة، بغية مسح اتجاهات القائمين بالاتصال حول مدى انعكاس السياسة الإعلامية في أثناء الأزمات على معاييرهم المهنية ، ويتمثل مجتمع البحث في القنوات الفضائية الدولية الناطقة باللغة العربية والموجهة للمنطقة العربية، اما عينة البحث فاختارها الباحث بأسلوب العينة العمدية على مستويين، - المستوى الاول: هي القنوات الفضائية الموجهة المرخصة للعمل في العراق فقط، وقد بلغ عددها سبع قنوات موجهة. - أما في المستوى الثاني: فهم القائمون بالاتصال في القنوات الفضائية العاملون في العراق فقط بلغ عددهم ) 55 ( مبحوثاً. أهم النتائج التي توصل اليها البحث هي ان القنوات الفضائية الموجهة تعتمد ابعاد السياسة الاعلامية بشكل واضح عن طريق اعتمادها لاعتبارات البعد التشريعي وذلك لإنَّ أهم الأشكال التي تفرضها السياسة الإعلامية في القنوات الفضائية الموجهة على القائمين بالاتصال هي فئة الالتزام ب)قوانين الرقابة( التي فاقت في نسبتها الفئات الأخرى جميعاً. وكذلك اظهر البحث إنَّ غالبية المبحوثين أكدوا ان السياسة الإعلامية للقنوات الفضائية الموجهة تسعى بشكل دائم لتحقيق البعد التكنولوجي وذلك عن طريق إلى مسايرة التكنولوجيا الحديثة، يتضح من ذلك حرص السياسة الإعلامية للقنوات الفضائية الموجهة بشكل عام التحري عن آخر التطورات التكنولوجية في ميدان الإعلام

With the increasing use of databases for environmental radiological monitoring in soils, food, water and sediments, among others, there is a demand for integrating this kind of information availability, aiming at a data management for greater searchability for the most varied purposes. ENVIRAD is a proposal to integrate these databases, providing researchers with a tool for a more complete analysis of the environment’s study. ENVIRAD, as developed so far, works with the integration of the following databases: MARIS, GLOMARD, GEORAD and SIGLARA databases, enabling queries and demonstrating great potential in the use of data integration for environmental samples.

هدفت الدراسة إلى التعرف على مدى مواءمة رسوم الأطفال مع خصائص الأسلوب التجريدي.وكذلك للتحقق من فرضية البحث التي وضعها الباحث لمعرفة هل توجد فروق ذات دلاله إحصائية عند مستوى دلالة (0.05) بين متوسط درجات الذكور و الإناث للرسم بالأسلوب التجريدي ، آذ أعد الباحث (استمارة تحليل) تتكون من (10) فقرات تتضمن خصائص الأسلوب التجريدي لقياس مدى ما تتضمنه رسوم الأطفال من خصائص هذا الأسلوب، وبعد تصميمها وعرضها على الخبراء مع موضوع الاختبار (منظر طبيعي، رسم العائلة) وأجراء التعديلات اللازمة عليها لتكون بصيغتها النهائية وتجربتها على العينة الاستطلاعية التي تكونت من (10) تلاميذ وبعد الـتأكد من صدقها وثباتها قام الباحث بتطبيقها على رسوم عينة البحث لـ(6) مدارس ابتدائية للبنين والبنات والتي بلغ عددها (132) تلميذ وتلميذة للصف الثالث الابتدائي من مجموع مجتمع البحث ل(95) مدرسة تابعة لمديرية تربية محافظة ميسان، والتي اختارها الباحث بشكل عشوائي مستخدما الحقيبة الإحصائية (spss) لاستخراج نتائج البحث في معرفة مدى كل فقرة من الفقرات التي تضمنها المقياس والمدى الكلي لمجموع الفقرات وكذلك حساب الفرق بين متوسط رسوم الذكور ومتوسط رسوم الإناث والانحراف المعياري لكلا الجنسين فأظهرت النتائج مؤشرا إيجابيا يدل على مدى مواءمة رسوم الأطفال لخصائص الأسلوب التجريدي وكذلك اظهر الفرق بينهما وكانت النتيجة لصالح الذكور.ومن ذلك أوصى الباحث باستخدام هذا الأسلوب كوسيلة تعليمية لتقديم الموضوعات المختلفة والمنفذة بهذا الأسلوب لللأطفال في دروس التربية الفنية وغيرها كونه أسلوب يتناسب مع قدراتهم وإمكاناتهم الجسمية والعقلية.