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Your search keyword '"Huijgens, Peter C."' showing total 222 results
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222 results on '"Huijgens, Peter C."'

15. Outcome of Intensively Treated Elderly AML Patients Reported to the Harmony Alliance Compares Well to Outcome of Control Patients of the Prospective Randomized HOVON 103 Study in Elderly AML

Author

Hermans, Sjoerd J.F., Versluis, Jurjen, van Norden, Yvette, van Werkhoven, Erik D., Janssen, Jeroen J.W.M., Huls, Gerwin A., Lowenberg, Bob, Pabst, Thomas, Breems, Dimitri A., Berkx, Elizabeth, Dinmohamed, Avinash G., Huijgens, Peter C., Sträng, Eric, Hernández-Rivas, Jesús María, Döhner, Hartmut, Sobas, Marta, Bullinger, Lars, Ayala, Rosa, Martinez-Lopez, Joaquin, Metzeler, Klaus H, Haferlach, Torsten, Thiede, Christian, Uyl-De Groot, Carin A., Ossenkoppele, Gert J., Pignatti, Francesco, and Cornelissen, Jan J.

Published
2023
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16. Risk of Severe Sars-Cov-2 Infections in COVID-19 Vaccinated Individuals with Hematologic Malignancies (SAVE HEM): A Nationwide Cohort Study in the Netherlands

Author

Hofsink, Quincy, Haggenburg, Sabine, Lissenberg-Witte, Birgit I., Goorhuis, Abraham, Hazenberg, Mette D., Rutten, Caroline E., Zweegman, Sonja, Kemmeren, Jeanet, de Keizer, Nicolette F., Huijgens, Peter C., Dinmohamed, Avinash G., van den Hof, Susan, de Gier, Brechje, Knol, Mirjam, Hahné, Susan, Heijmans, Jarom, and Nijhof, Inger S.

Published
2023
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27. Development of a national quality framework for palliative care in a mixed generalist and specialist care model: A whole-sector approach and a modified Delphi technique.

Author

Boddaert, Manon S., Douma, Joep, Dijxhoorn, Anne-Floor Q., Héman, René A. C. L., van der Rijt, Carin C. D., Teunissen, Saskia S. C. M., Huijgens, Peter C., and Vissers, Kris C. P.

Subjects
PALLIATIVE treatment, DELPHI method, MEDICAL personnel, GENERAL practitioners, MEDICAL specialties & specialists, PATIENTS' families
Abstract

In a predominantly biomedical healthcare model focused on cure, providing optimal, person-centred palliative care is challenging. The general public, patients, and healthcare professionals are often unaware of palliative care's benefits. Poor interdisciplinary teamwork and limited communication combined with a lack of early identification of patients with palliative care needs contribute to sub-optimal palliative care provision. We aimed to develop a national quality framework to improve availability and access to high-quality palliative care in a mixed generalist-specialist palliative care model. We hypothesised that a whole-sector approach and a modified Delphi technique would be suitable to reach this aim. Analogous to the international AGREE guideline criteria and employing a whole-sector approach, an expert panel comprising mandated representatives for patients and their families, various healthcare associations, and health insurers answered the main question: 'What are the elements defining high-quality palliative care in the Netherlands?'. For constructing the quality framework, a bottleneck analysis of palliative care provision and a literature review were conducted. Six core documents were used in a modified Delphi technique to build the framework with the expert panel, while stakeholder organisations were involved and informed in round-table discussions. In the entire process, preparing and building relationships took one year and surveying, convening, discussing content, consulting peers, and obtaining final consent from all stakeholders took 18 months. A quality framework, including a glossary of terms, endorsed by organisations representing patients and their families, general practitioners, elderly care physicians, medical specialists, nurses, social workers, psychologists, spiritual caregivers, and health insurers was developed and annexed with a summary for patients and families. We successfully developed a national consensus-based patient-centred quality framework for high-quality palliative care in a mixed generalist-specialist palliative care model. A whole-sector approach and a modified Delphi technique are feasible structures to achieve this aim. The process we reported may guide other countries in their initiatives to enhance palliative care. [ABSTRACT FROM AUTHOR]

Published
2022
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34. Autologous bone marrow transplantation as consolidation therapy in the treatment of adult patients under 60 years with acute myeloid leukaemia in first complete remission: a prospective randomized Dutch–Belgian Haemato-Oncology Co-operative Group (HOVON) and Swiss Group for Clinical Cancer Research (SAKK) trial

Author

Breems, Dimitri A., Boogaerts, Marc A., Dekker, Adriaan W., Van Putten, Wim L. J., Sonneveld, Pieter, Huijgens, Peter C., Van der Lelie, Johannes, Vellenga, Edo, Gratwohl, Alois, Verhoef, Gregor E. G., Verdonck, Leo F., and Löwenberg, Bob

Published
2005

35. Addition of cyclosporin A to the combination of mitoxantrone and etoposide to overcome resistance to chemotherapy in refractory or relapsing acute myeloid leukaemia:: A randomised phase II trial from HOVON, the Dutch–Belgian Haemato-Oncology Working Group for adults

Author

Daenen, Simon, van der Holt, Bronno, Verhoef, Gregor E.G, Löwenberg, Bob, Wijermans, Pierre W, Huijgens, Peter C, van Marwijk Kooy, Rien, Schouten, Harry C, Kramer, Mark H.H, Ferrant, Augustin, van den Berg, Eva, Steijaert, Monique M.C, Verdonck, Leo F, and Sonneveld, Pieter

Published
2004
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45. Distress and quality of life after autologous stem cell transplantation: a randomized clinical trial to evaluate the outcome of a web-based stepped care intervention

Author

Huijgens Peter C, Cuijpers Pim, Eeltink Corien, Boenink Annette D, van Oppen Patricia, Visser Otto, van Meijel Berno, Braamse Annemarie MJ, Beekman Aartjan TF, and Dekker Joost

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background Psychological distress (i.e. depression and anxiety) is a strong predictor of functional status and other aspects of quality of life in autologous stem cell transplantation following high-dose chemotherapy. Treatment of psychological distress is hypothesized to result in improvement of functional status and other aspects of quality of life. The aim is to evaluate the outcome of stepped care for psychological distress on functional status and other aspects of quality of life in patients with hematological malignancy treated with autologous stem cell transplantation. Methods/Design The study is designed as a randomized clinical trial with 2 treatment arms: a stepped care intervention program versus care as usual. Patients are randomized immediately pre transplant. Stepped care and care as usual are initiated after a 6 weeks buffer period. Outcome is evaluated at 13, 30, and 42 weeks post transplant. In the experimental group, the first step includes an Internet-based self-help program. If psychological distress persists after the self-help intervention, the second step of the program is executed, i.e. a diagnostic evaluation and a standardized interview, yielding a problem analysis. Based on this information, a contract is made with the patient and treatment is provided consisting of individual face-to-face counseling, medication, or referral to other services. Care as usual comprises an interview with the patient, on ad hoc basis; emotional support and advice, on ad hoc basis; if urgent problems emerge, the patient is referred to other services. Primary outcome variables are psychological distress and functional status. Data are analyzed according to the intention to treat-principle. Discussion This study has several innovative characteristics. First, the outcome of the intervention for psychological distress in patients with hematological malignancy treated with autologous stem cell transplantation is evaluated in a randomized controlled study. Second, the impact of the intervention on functional status is evaluated: it is hypothesized that reduction of psychological distress results in improved functional status. Furthermore, the intervention concerns an Internet-based treatment in the first step. Finally, the intervention is characterized by an emphasis on self-management, efficiency, and a multi-disciplinary approach with nurses taking up a central role. Trial Registration NTR1770

Published
2010
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50. A population-based study on different regimens of R-CHOP in patients with newly diagnosed DLBCL in The Netherlands.

Author

Issa, Djamila E., Dinmohamed, Avinash G., Wondergem, Marielle J., Blommestein, Hedwig M., Huijgens, Peter C., Lugtenburg, Pieternella J., Visser, Otto, Zweegman, Sonja, and Chamuleau, Martine E. D.

Subjects
DIFFUSE large B-cell lymphomas, ANTINEOPLASTIC combined chemotherapy protocols, MORTALITY
Abstract

Randomized controlled trials have studied different dose-intensity and dose-interval regimens of R-CHOP for patients with diffuse large B-cell lymphoma (DLBCL). This study was undertaken to confirm these results in a population-based setting, with special emphasis on the value of 6xR-CHOP21 among patients aged 18–64 years. Two thousand three hundred and thirty-eight stage II–IV DLBCL patients, ≥18 years, we confirmed the similar efficacy of six versus eight cycles of R-CHOP and of R-CHOP21 versus R-CHOP14 regimens across all age groups on overall survival (median follow-up 36.4 (1.3–167.6) months). Nevertheless, overall survival decreased with older age. Interestingly, in patients 18–64 years, the adjusted risk of mortality among recipients of 6xR-CHOP21 compared to other R-CHOP regimens seems to be similar (HR 0.62; 95%CI: 0.38–1.02; p=.059). Although this finding might suggest that 6xR-CHOP21 could be considered as first-line regimen for all stage II–IV DLBCL patients, it should be confirmed in forthcoming population-based studies with larger patient numbers and longitudinal follow-up. [ABSTRACT FROM AUTHOR]

Published
2021
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