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FAM20C, a member of the family with sequence similarity 20, is involved in many physiological functions. Obesity, characterized by excessive accumulation of adipose tissue, has attracted more and more attention as a worldwide health problem. Here we generated adipocyte‐specific FAM20C knockout mice to investigate the role of FAM20C in adipose tissue expansion and obesity. Our results demonstrate that knockout mice are protected against high fat diet‐induced obesity, adiposity, and fatty liver disease. Additionally, knockout mice exhibited improved metabolic phenotypes, including enhanced glucose tolerance and insulin sensitivity compared with control mice. Furthermore, we observed reduced inflammatory infiltration and collagen deposition in the adipose tissues of knockout mice. Taken together, our results indicate that targeting FAM20C in adipocytes may be a promising strategy for the treatment of obesity and associated metabolic disorders. [ABSTRACT FROM AUTHOR]

In order to gain a price advantage in the competition with AMOLED and a‐Si LCD, the manufacturing process of LTPS LCD is simplified. Several mask‐reduction technologies such as SALDD, LSM lessness, and PLN lessness are developed, and LTPS LCD with 9‐mask, 8‐mask, and 7‐mask technologies has been mass produced. [ABSTRACT FROM AUTHOR]

Introduction: Diabetes and obesity are momentous risk factors threatening people's lives and health. Currently available incretin analogue glucagon-like peptide 1 (GLP-1) possesses huge hypoglycemic effect with the unsatisfactory effect of weight loss. Co-agonists targeting GLP-1R plus glucagon receptor (GCGR) or gastric inhibitory polypeptide receptor (GIPR) show synergistic benefits in glycaemic control and weight loss. Here, we describe a novel dual GIP and GLP-1 receptor agonist, DR10627, and performed a preclinical assessment of it. Methods: The agonistic ability of DR10627 was indirectly assessed by inducing cAMP accumulation in Chinese hamster ovary (CHO) cells transfected with GLP-1R or GIPR in vitro. The plasma pharmacokinetics of DR10627 were analysed in cynomolgus monkeys. The OGTTs were performed in Sprague‑Dawley (SD) rats. The glucose lowering effects were evaluated by repeated administration of DR10627 in diabetic (db/db) mice for 4 weeks. The effects of anti-obesity and improving metabolism of DR10627 were evaluated by repeated administration of DR10627 in diet-induced obesity (DIO) mice for 57 days. Results: DR10627 had the capacity to activate both GLP-1R and GIPR in vitro. The terminal half-life of DR10627 was found to be approximately 4.19– 5.8 h in cynomolgus monkeys. DR10627 had a great improvement in oral glucose tolerance in SD rats. Moreover, DR10627 had a potent glucose-lowering effect in db/db mice, and the hypoglycemic effect of 18 nmol/kg DR10627 was better than that of 50 nmol/kg liraglutide. In addition, 10 and 30 nmol/kg DR10627 possessed the ability of potentiating the weight-loss, lipid-lowing efficacy and improving metabolism to a greater extent than 80 nmol/kg liraglutide. Conclusion: Preclinical assessment demonstrated that administration of DR10627 resulted in glucose lowering in SD rats and db/db mice, and substantial body weight reduction and metabolism improvement in DIO mice. DR10627 is a promising agent deserving further investigation for the treatment of type 2 diabetes and obesity. [ABSTRACT FROM AUTHOR]

Aim: This study aimed to explore the relationship between nurses' occupational exposure to antineoplastic agents and adverse pregnancy outcomes. Design: Meta‐analysis. Methods: Data were retrieved from studies published before April 2022 in PubMed, the Cochrane Library, the Web of Science, Embase databases, the China National Knowledge Infrastructure (CNKI), China Biology Medicine disc (CBM), China Science and Technology Journal databases (VIP) and Wan Fang databases (WF). Stata MP (Version 17.0) was used to conduct this meta‐analysis. Results: The current evidence shows that occupational exposure to antineoplastic agents increases nurses' risk of spontaneous abortions, stillbirths, and congenital abnormalities. It is necessary to pay attention to occupational exposures caused by antineoplastic agents, especially for female nurses of reproductive age. Managers should take timely and effective countermeasures to ensure their occupational safety and reduce the risk of adverse pregnancy outcomes. [ABSTRACT FROM AUTHOR]

With an inbuilt structure of using the inorganic film passivation layer instead of the organic layers in Liquid Crystal Display with 7mask technology, sealing force is deteriorated. This paper is devoted to find the mechanism of the deterioration and developed a way to improve. [ABSTRACT FROM AUTHOR]

Claudin 18.2 (CLDN18.2), a tight junction (TJ) family protein controlling molecule exchange between cells, is frequently over-expressed in gastric cancer, pancreatic adenocarcinomas and in a fraction of non–small cell lung cancer cases. The tumor properties indicate that CLDN18.2 could be an attractive drug target for gastric and pancreatic cancers. In this study, we present effective strategies for developing anti-CLDN18.2 therapeutic candidates, based on variable domain of heavy chain of heavy chain antibodies (VHHs). CLDN18.2-specific VHHs were isolated by panning a phage display library from an alpaca immunized with a stable cell line highly expressing CLDN18.2. Humanized VHHs fused with human IgG1 Fc, as potential therapeutic candidates, exhibited desirable binding specificity and affinity to CLDN18.2. In vitro experiments showed that hu7v3-Fc was capable of eliciting both antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC) on CLDN18.2 positive tumor cells. In the mouse xenograft model, the anti-tumor efficacy of hu7v3-Fc was significantly more potent than Zolbetuximab, the benchmark anti-CLDN18.2 monoclonal antibody. Moreover, in vivo biodistribution using zirconium-89 (89Zr) labeled antibodies demonstrated that hu7v3-Fc (89Zr-hu7v3-Fc) exhibited a better tumor penetration and a faster tumor uptake than Zolbetuximab (89Zr-Zolbetuximab), which might be attributed to its smaller size and higher affinity. Taken together, anti-CDLN18.2 hu7v3-Fc is a promising therapeutic agent for human CLDN18.2 positive cancers. Furthermore, hu7v3 has emerged as a potential module for novel CLDN18.2 related therapeutics. [ABSTRACT FROM AUTHOR]

2D transition metal carbides and/or nitrides (MXenes), by virtue of high electrical conductivity, abundant surface functional groups and excellent dispersion in various solvents, are attracting increasing attention and showing competitive performance in energy storage and conversion applications. However, like other 2D materials, MXene nanosheets incline to stack together via van der Waals interactions, which lead to limited number of active sites, sluggish ionic kinetics, and finally ordinary performance of MXene materials/devices. Constructing 2D MXene nanosheets into 3D architectures has been proven to be an effective strategy to reduce restacking, thus providing larger specific surface area, higher porosity, and shorter ion and mass transport distance over normal 1D and 2D structures. In this review, the commonly used strategies for manufacturing 3D MXene architectures (3D MXenes and 3D MXene‐based composites) are summarized, such as template, assembly, 3D printing, and other methods. Special attention is also given to the structure–property relationships of 3D MXene architectures and their applications in electrochemical energy storage and conversion, including supercapacitors, rechargeable batteries, and electrocatalysis. Finally, the authors propose a brief perspective on future opportunities and challenges for 3D MXene architectures/devices. [ABSTRACT FROM AUTHOR]

A nitrogen‐doped carbon layer coating on a 3D graphene framework (NCL@GF) was produced by the in‐situ polymerization of a uniform polyimide layer on the graphene framework surface and a carbonization process. The NCL@GF exhibited a 3D macroporous structure with uniform N‐doped porous carbon layers and a high 5.4 at. % nitrogen content, which not only effectively enhanced the active sites but also facilitated fast ion and electron transport in the 3D pathways. Consequently, the NCL@GF as the anode of a sodium‐ion battery (SIB) exhibited a discharge capacity of 357 mAh g−1 at 0.1 A g−1 after 200 cycles, a remarkable rate capability with a capacity of 122 mAh g−1 at 8 A g−1, and a super long cycle life with a capacity retention of 70 % capacity after 2500 cycles at 0.5 A g−1. Such performance is superior to that of previously reported carbon or graphene‐based composites. Energy storage: NCL@GF manifested 3D frameworks of interconnect macropores and N‐doped carbon layer showed an outstanding sodium storage performance. [ABSTRACT FROM AUTHOR]

The construction of flexible and stretchable supercapacitors with high energy density and superior stability is critical for modern wearable electronics but still remains considerably challenging. Herein we develop an ultrahigh-performance stretchable asymmetric supercapacitor (SASC) by using electrically and mechanically robust three-dimensional graphene frameworks as electrodes for the first time, in which three-dimensional graphene and a deliberately designed three-dimensional graphene/polyaniline composite are employed as the anode and cathode, respectively. The newly developed SASCs show the highest energy density of 77.8 W h kg−1 among all reported stretchable supercapacitors, and also deliver exceptional cycling stability with 95.6% capacitance retention after 10 000 charge–discharge cycles and excellent electrochemical durability with 91.2% capacitance retention after 100 stretching cycles at a large strain of 100%. The practicability of our SASC has been further demonstrated by efficiently powering a light-emitting diode indicator (1.8 V, 10 mA) under repeated stretching of a SASC mounted on a finger. Moreover, by connecting three SASCs in series, the tandem device can even drive an STC89C51RC microcontroller-based complex circuit (5.0 V) to light a liquid crystal display. [ABSTRACT FROM AUTHOR]

Small conjugated carbonyl compounds are intriguing candidates for organic electrode materials because of their abundance, high theoretical capacity, and adjustable molecular structure. However, their dissolution in aprotic electrolytes and poor conductivity eclipse them in terms of practical capacity, cycle life, and rate capability. Herein, we report a foldable and binder-free nanocomposite electrode consisting of 2-aminoanthraquinone (AAQ) nanowires wrapped within the 3 D graphene framework, which is prepared through antisolvent crystallization followed by a facile chemical reduction and selfassembly process. The nanocomposite exhibited a very high capacity of 265 mA h g−1 at 0.1 C for AAQ, realizing 100 % utilization of active material. Furthermore, the nanocomposite shows superior cycling stability (82 % capacity retention after 200 cycles at 0.2 C and 76 % capacity retention after 1000 cycles at 0.4 C) and excellent rate performance (153 mA h g−1 at 5 C). Particularly, the nanocomposite can deliver the highest capacity of 165 mA h g−1 among all reported anthraquinone- and anthraquinone-analogues-based electrodes per mass of the whole electrode, which is essential for practical application. Such outstanding electrochemical performance could be largely attributed to the wrapping structure of the flexible composite, which provides both conductivity and structural integrity. [ABSTRACT FROM AUTHOR]

Here we report a unique hierarchical free-standing graphene/polyaniline (G/PANI) composite electrode with ultrathin G/PANI composite nanosheets embedded in the skeleton of a three-dimensional (3D) graphene framework. Due to the intrinsic structural advantage of ultrathin G/PANI composite nanosheets and their synergetic interaction with the 3D graphene network, the 3D-G/PANI composite electrode can deliver a high specific capacitance of 777 F g−1 and 990 F cm−3 at 1 A g−1 and an exceptional cycling stability with 85% capacitance retention after 60 000 deep cycles in a three-electrode cell configuration. The further assembled all-solid-state supercapacitor based on the 3D-G/PANI composite electrode can not only show extraordinary mechanical flexibility allowing bending, twisting and folding, but also demonstrate remarkable electrochemical performance under its folded state, including an ultrahigh specific capacitance of 665 F g−1 and 847 F cm−3 for the 3D-G/PANI composite electrode, excellent rate capability with a capacitance retention of 86% at 20 A g−1 and superior cycling stability with no capacitance decay after 10 000 cycles, as well as ultralow self-discharge characteristics. Furthermore, the entire ultrathin device (∼45 μm, much thinner than a commercial standard A4 paper) can deliver volumetric, gravimetric and areal energy densities up to 14.2 mW h cm−3, 10.9 W h kg−1 and 64 μW h cm−2, respectively, which are much higher than those of current high-level commercial supercapacitors (∼5 W h kg−1) and even lithium thin-film batteries (∼8 mW h cm−3, 4 V/500 μA h). [ABSTRACT FROM AUTHOR]

Organic cathodes, especially conjugated carbonyl polymers, have been developed as promising alternatives to inorganic cathodes for rechargeable lithium and sodium batteries due to their high theoretical capacities, fast reaction kinetics, mechanical flexibility, environmental sustainability, and structural diversity. However, because of the intrinsic electrical insulation of conjugated carbonyl polymers, it is a great challenge to simultaneously achieve high capacity, high rate capability, and long cycle life. In this paper we report, for the first time, the preparation of monolithic 3D graphene/polyimide composites (GF–PI) through a one-step solvothermal strategy with simultaneous in situ polymerization of PI on the graphene surface and self-assembly of graphene into a 3D network structure. The mechanically strong GF–PI can be used directly as highly flexible lithium-ion-battery (LIB) cathodes without adding any other binder or conductive carbon and deliver a very high reversible capacity (240 mA h g−1 at 40 mA g−1), excellent rate capability (102 mA h g−1 at 4000 mA g−1) and remarkable cycling stability (81.2% capacity retention after 600 cycles at 100 mA g−1). The flexible GF–PI electrode also delivers an ultrahigh Na storage capacity of 213 mA h g−1 at 50 mA g−1, and outstanding capacity retention of 80.4% after 1000 cycles at 1000 mA g−1 when used as a sodium-ion-battery (SIB) cathode. The comprehensive electrochemical performances of GF–PI are superior to those of the state-of-art PI-based LIB and SIB cathodes that have been reported thus far. [ABSTRACT FROM AUTHOR]

Hierarchically porous nitrogen-doped graphene frameworks (N-GFs) are fabricated through the ice-templating of GO with polyethylenimine and the thermal treatment of the resultant hybrids. As cathode materials in lithium ion batteries (LIBs), the obtained N-GFs exhibit an outstanding specific capacity of 379 mA h g−1 at 0.5 A g−1 for 2500 cycles. Even at an ultrahigh current density of 5 A g−1, the N-GFs maintain a capacity of 94 mA h g−1, superior to that of most reported LIB cathode materials. The experimental results and quantum mechanics calculations suggest that pyridinic-like N and pyridinic N-oxide in graphene are responsible for the excellent cathodic performance of the bipolar N-GFs by providing fast surface faradaic reactions with both p- and n-doped states. [ABSTRACT FROM AUTHOR]

The increasing demand for energy and growing concerns for environmental issues are promoting the development of organic electrode materials. Among these, conjugated carbonyl compounds (CCCs) represent one of the most attractive and promising candidates for sustainable and eco-benign energy storage devices in the coming future. However, most of the current compounds suffer from dissolution in organic electrolytes and low electronic conductivity, which result in severe capacity decay and poor rate performance. Recently, researchers have achieved considerable progress by introducing electroactive carbonyl compounds into carbon nanomaterials. This perspective provides an overview of the up-to-date development of these nanocomposites in metal ion batteries (lithium-ion batteries or sodium-ion batteries) and supercapacitors (SCs), including the synthesis, performance improvement and applications. We mainly focus on carbon nanotubes (CNTs), graphene and mesoporous carbon (MC) as carbon nanomaterials because of their high specific surface area, good conductivity, electrochemical stability and favourable interaction with conjugated carbonyl compounds. This strategy opens up new possibilities to realize cost-effective, sustainable and versatile energy storage devices. [ABSTRACT FROM AUTHOR]

A three-dimensional polymeric carbon nitride/graphene framework (CN/GF) was fabricated by the ionic self-assembly of graphene oxide and protonated polymeric carbon nitride nanosheets. As the cathode material in lithium-ion batteries, CN/GF showed an excellent reversible capacity of 184 mA h g−1 at 0.05 A g−1 for 150 cycles and maintained the capacity of 60 mA h g−1 at 5 A g−1. [ABSTRACT FROM AUTHOR]

A dual-doping approach for nitrogen-doped carbon-coated SnO2–SnS/graphene nanosheets (N–C@SnO2–SnS/GN) has been developed, using hydrothermal carbonization of sucrose with SnO2-decorated graphene and ammonium thiocyanate and a subsequent thermal treatment. The resulting hybrid manifests a typical two-dimensional core–shell architecture, with a N-doped carbon coating over the SnS- and SnO2-decorated graphene nanosheets. Used as the anode material in lithium ion batteries (LIBs), N–C@SnO2–SnS/GN delivers a high specific capacity of 1236 mA h g−1 at a current density of 0.1 A g−1 after 110 cycles, which outperforms most state-of-the-art tin-based LIB anodes with core–shell structures. [ABSTRACT FROM AUTHOR]

Heteroatom doping is an effective method to adjust the electrochemical behavior of carbonaceous materials. In this work, boron-doped, carbon-coated SnO2/graphene hybrids (BCTGs) were fabricated by hydrothermal carbonization of sucrose in the presence of SnO2/graphene nanosheets and phenylboronic acid or boric acid as dopant source and subsequent thermal treatment. Owing to their unique 2D core-shell architecture and B-doped carbon shells, BCTGs have enhanced conductivity and extra active sites for lithium storage. With phenylboronic acid as B source, the resulting hybrid shows outstanding electrochemical performance as the anode in lithium-ion batteries with a highly stable capacity of 1165 mA h g−1 at 0.1 A g−1 after 360 cycles and an excellent rate capability of 600 mA h g−1 at 3.2 A g−1, and thus outperforms most of the previously reported SnO2-based anode materials. [ABSTRACT FROM AUTHOR]

3D hierarchical tin oxide/graphene frameworks (SnO2/GFs) were built up by the in situ synthesis of 2D SnO2/graphene nanosheets followed by hydrothermal assembly. These SnO2/GFs exhibited a 3D hierarchical porous architecture with mesopores (≈3 nm), macropores (3-6 μm), and a large surface area (244 m2 g−1), which not only effectively prevented the agglomeration of SnO2 nanoparticles, but also facilitated fast ion and electron transport in 3D pathways. As a consequence, the SnO2/GFs exhibited a high capacity of 830 mAh g−1 for up to 70 charge-discharge cycles at 100 mA g−1. Even at a high current density of 500 mA g−1, a reversible capacity of 621 mAh g−1 could be maintained for SnO2/GFs with excellent cycling stability. Such performance is superior to that of previously reported SnO2/graphene and other SnO2/carbon composites with similar weight contents of SnO2. [ABSTRACT FROM AUTHOR]

Keywords: 2D materials; 3D architectures; energy storage and conversion; MXene devices; MXene nanosheets; porous materials EN 2D materials 3D architectures energy storage and conversion MXene devices MXene nanosheets porous materials 1 1 1 11/20/20 20201118 NES 201118 In article number 2000842, Valeria Nicolosi, Yuxi Xu, and co-workers review the commonly used strategies for manufacturing 3D MXene architectures. Special attention is also given to understand the structure-property relationships of 3D MXene architectures and highlight their promising applications in electrochemical energy storage and conversion, including supercapacitors, rechargeable batteries, and electrocatalysis. 2D materials, 3D architectures, energy storage and conversion, MXene devices, MXene nanosheets, porous materials. [Extracted from the article]

We designed CdS core-Au/MXene-based photodetector with inverse photoresponse and detection of broad spectrum from deep-UV to near infrared. • Broad spectrum from deep-ultraviolet to near-infrared. • Larger specific detectivity (1.34 × 1011 Jones) are observed. • The detectors owned dual photoresponse. Exploring photodetectors with higher responsitivity and broader spectral response is crucial for optoelectronic applications. Inverse photoresponse is discovered from photodetectors based on cadmium sulfide modified by Au (CdS core-Au). The devices are capable of detecting photons with a broader spectrum from deep-ultraviolet to near-infrared. Under the illumination of visible light at 405 nm, negative photoresponse with higher responsivity (86 mA/W) and larger specific detectivity (1.34 × 1011 Jones) are observed owing to the thermal mechanism. Upon deep-ultraviolet light illumination, the photodetectors exhibit positive photoresponse. These findings provide a new approach to broad spectral photodetectors and other inventive optoelectronic devices. [ABSTRACT FROM AUTHOR]

Purpose: This study aims to explore the incidence and clinical features of MYD88 and CXCR4 mutations in patients with Waldenström macroglobulinemia (WM) and determine the optimal method for routine clinical practice. Additionally, we seek to evaluate the prognostic significance of these features across various therapeutic backgrounds [cytotoxic group, the Rituximab/Bortezomib-based group, and the Bruton's tyrosine kinase inhibitor (BTKi) group]., Experimental Design: 385 symptomatic WM patients were analyzed for MYD88 and CXCR4 mutations using Sanger sequencing, next-generation sequencing (NGS), allele-specific quantitative polymerase chain reaction (AS-PCR), and/or droplet digital PCR (ddPCR)., Results: The overall MYD88 mutation rate was 87.8%, relatively lower than that in Western cohort. Both AS-PCR and ddPCR demonstrated high sensitivity in unsorted samples, detecting 98.5% and 97.7% of mutations, respectively, including those with low tumor burdens. The total CXCR4 mutation rate was 30.9%, with NGS exhibiting the highest sensitivity of 78.0%. CXCR4 mutation was significantly linked to shorter OS only within the BTKi treatment group. The multivariate analysis indicated that MYD88 and CXCR4 mutations were not independent prognostic factors in the non-BTKi group when considering IPSSWM clinical staging. However, in the BTKi treatment group, these mutations emerged as independent adverse prognostic factors, overshadowing the prognostic significance of IPSSWM classification (MYD88: HR=0.229, P=0.030; CXCR4: HR=3.349, P=0.012)., Conclusions: Testing for MYD88 mutations using AS-PCR or ddPCR in unsorted samples is viable for routine clinical practice. Under BTKi treatment, MYD88 and CXCR4 mutations hold greater prognostic importance than IPSSWM staging in WM.

Introduction: Bruton tyrosine kinase inhibitor (BTKi) has demonstrated substantial efficacy in treating B-cell lymphoproliferative diseases (BLPD). Nonetheless, the significant discontinuation rates due to toxicity or financial reasons cannot be overlooked. In China, empirical evidence on the usage of BTKi remains scarce., Methods: To address this, a retrospective cohort study was conducted focused on 673 Chinese patients with BLPD who underwent at least one month of BTKi therapy., Results: Median age at BTKi initiation was 60 years. The median duration on BTKi treatment of the whole cohort was 36.4 months. The median post-BTK survival was not reach. BTKi-based treatment was permanently discontinued in 288 (43.8%) patients during follow-up, mostly attributed to progressive disease. Within the first 6 months of BTKi treatment, 76 patients (26.3%) had early treatment discontinuation. Patients with early discontinuation had extreme worse outcome with a median post-discontinuation survival of only 6.9 months. On multivariate analysis, withdrawal BTKi by toxicity and withdrawal BTKi within 6 months retained to be independent predictors of post-BTK survival, after taking account of the response depth, lines of therapy and baseline cytogenetics including 17p deletion. The decision between BTKi monotherapy and combination therapy, along with the preference for first or second-generation BTKi, exerted no significant impact on survival., Discussions: These observations contribute valuable real-world insights into the utilization of BTKi in China. We concluded that BTKi is an effective and well-tolerated treatment for long-term use in Chinese patient population. However, it is imperative to stress that a proportion of patients discontinue BTKi early, leading to suboptimal outcomes. This study underscores the importance of adherence to BTKi therapy for improved clinical outcomes in real-world patients., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2023 Yan, Lv, Wang, Yu, Huang, Xiong, Li, Sui, Wang, Huang, An, Zou, Wang, Qiu and Yi.)

Introduction: Minimal residual disease (MRD) has been recognized as an important prognostic factor of survival in patients with hematological malignancies. However, the prognostic value of MRD in Waldenström macroglobulinemia (WM) remains unexplored., Methods: We analyzed 108 newly diagnosed WM patients receiving systematic therapy and assessed for MRD by multiparameter flow cytometry (MFC) using bone marrow samples., Results: Of the total patients, 34 (31.5%) achieved undetectable MRD (uMRD). A hemoglobin level of >115 g/L (P=0.03), a serum albumin level of >35 g/L (P=0.01), a β2-MG level of ≤3 mg/L (P=0.03), and a low-risk International Prognostic Scoring System for WM (IPSSWM) stage (P<0.01) were associated with a higher rate of uMRD. Improvements in monoclonal immunoglobulin (P<0.01) and hemoglobin (P=0.03) levels were more evident in uMRD patients compared with that in MRD-positive patients. The 3-year progression-free survival (PFS) was better in uMRD patients compared with that in MRD-positive patients (96.2% vs. 52.8%; P=0.0012). Landmark analysis also showed that uMRD patients had better PFS compared with MRD-positive patients after 6 and 12 months. Patients who achieved partial response (PR) and uMRD had a 3-year PFS of 100%, which was significantly higher than that of patients with MRD-positive PR (62.6%, P=0.029). Multivariate analysis showed that MRD positivity was an independent factor of PFS (HR: 2.55, P=0.03). Moreover, the combination of the 6th International Workshop on WM assessment (IWWM-6 Criteria) and MRD assessment had a higher 3-year AUC compared with the IWWM-6 criteria alone (0.71 vs. 0.67)., Discussion: MRD status assessed by MFC is an independent prognostic factor for PFS in patients with WM, and its determination could improve the precision of response evaluation, especially in patients who achieved PR., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2023 Xiong, Wang, Wang, Yu, Huang, Sun, Chen, Lyu, Wang, Yan, Wang, Liu, An, Sui, Huang, Zou, Xiao, Wang, Ouyang, Qiu and Yi.)