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Abstract Background Limonium Sinense (Girard) Kuntze (L. sinense) has been widely used for the treatment of anaemia, bleeding, cancer, and other disorders in Chinese folk medicine. The aim of this study is to predict the therapeutic effects of L. sinense and investigate the potential mechanisms using integrated network pharmacology methods and in vitro cellular experiments. Methods The active ingredients of L. sinense were collected from published literature, and the potential targets related to L. sinense were obtained from public databases. Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) and DisGeNET enrichment analyses were performed to explore the underlying mechanisms. Molecular docking, cellular experiments, RNA-sequencing (RNA-seq) and Gene Expression Omnibus (GEO) datasets were employed to further evaluate the findings. Results A total of 15 active ingredients of L. sinense and their corresponding 389 targets were obtained. KEGG enrichment analysis revealed that the biological effects of L. sinense were primarily associated with “Pathways in cancer”. DisGeNET enrichment analysis highlighted the potential role of L. sinense in the treatment of breast cancer. Apigenin within L. sinense showed promising potential against cancer. Cellular experiments demonstrated that the L. sinense ethanol extract (LSE) exhibited a significant growth inhibitory effect on multiple breast cancer cell lines in both 2D and 3D cultures. RNA-seq analysis revealed a potential impact of LSE on breast cancer. Additionally, analysis of GEO datasets verified the significant enrichment of breast cancer and several cancer-related pathways upon treatment with Apigenin in human breast cancer cells. Conclusion This study predicts the biological activities of L. sinense and demonstrates the inhibitory effect of LSE on breast cancer cells, highlighting the potential application of L. sinense in cancer treatment.

An all-fiber low-repetition-rate SESAM mode-locked fiber oscillator combined with a dispersion-managed active fiber loop produces a flexible GHz burst-mode laser source. The high-power output is then produced by amplifying the GHz burst-mode laser source using an all-fiber chirped-pulse amplification system. Then, the laser is compressed using a grating pair compressor; a maximum amplified power of 97 W is obtained. This results in a compressed high power of 82.07 W with a power stability RMS of 0.09% and beam quality better than 1.2. Accurate dispersion control allows for the production of a high-quality pulse duration of 265 fs.

Due to severe information degradation, underwater image deblurring remains a challenging ill-posed problem. However, most deep learning models do not adequately exploit the hierarchical features of the original underwater images. They typically use clear images as positive samples to guide the training of image enhancement networks, while neglecting the utilization of negative information. In this paper, we introduce the Residual Dense Block (RDB) and Contrastive Regularization (CR) techniques. By leveraging the local and global feature fusion of RDB and the contrastive learning of CR, our model effectively extracts multi-level features from the original images, adaptively preserves hierarchical features, and achieves high-quality underwater image deblurring through learning from the original images. Experimental results demonstrate that our model outperforms other comparative algorithms in terms of subjective visual quality and objective evaluation metrics across four datasets.

Abstract Background The retrospective observational study aimed to evaluate the safety and efficacy of suctioning flexible ureteroscopy with Intelligent pressure-control (SFUI) on treating upper urinary tract calculi in a large cohort. Methods Between July 2020 and August 2021, 278 patients with upper urinary tract calculi who underwent SFUI in our hospital were enrolled. Outcomes were stone-free rate (SFR) in one session and one-month after SFUI treatment, and complications scored by the Clavien-Dindo classification. Results A total of 310 kidneys underwent SFUI were included. The median surgery time was 75 min (ranged 60–110 min). One session and one-month SFRs were 80.65% and 82.26%, respectively. The one-session SFR was ≧ 87% in patients with Guy’s stone score of Grade I among stone size

Limonium Sinense (Girard) Kuntze is a traditional Chinese medicinal herb, showing blood replenishment, anti-tumour, anti-hepatitis, and immunomodulation activities amongst others. However, the mechanism of its pharmacological activities remains largely unknown. Here, we investigated the effects of bioactive ingredients from Limonium Sinense using an integrated approach. Water extracts from Limonium Sinense (LSW) showed a strong growth inhibitory effect on multiple cells in both 2D and 3D cultures. Global transcriptomic profiling and further connectivity map (CMap) analysis identified several similarly acting therapeutic candidates, including Tubulin inhibitors and hypoxia-inducible factor (HIF) modulators. The effect of LSW on the cell cycle was verified with flow cytometry showing a G2/M phase arrest. Integrated analysis suggested a role for gallic acid in mediating HIF activation. Taken together, this study provides novel insights into the bioactive ingredients in Limonium Sinense, highlighting the rich natural resource and therapeutic values of herbal plants.

Thermal defects and low precision are the main disadvantages of fabricating micro-holes, irregular holes, and micro-slots in thermostable aviation materials. We demonstrate a manufacturing method employing a femtosecond laser and piezoelectric ceramic (PZT). The production process parameters were optimized according to the metallographic and dimensional accuracy of the microstructure, which was measured by phase-contrast microscopy and scanning electron microscopy. The limitations in a conventional aeroengine, such as in the recast layer, recrystallization, and micro-cracks, which degrade the performance and service life, were resolved with a simple, controllable, and commercial method. [ABSTRACT FROM AUTHOR]