1. Association of Caspase-8 Genotypes With Oral Cancer Risk in Taiwan
- Author
-
Da Tian Bau, Huai Mei Hsu, Yun Chi Wang, Liang Chun Shih, Te Chun Shen, Meng Liang Lin, Chi Li Gong, Wen Shin Chang, Chia-Wen Tsai, Yueh Ting Tsai, and Kuo-Ting Sun
- Subjects
Oncology ,Adult ,Male ,Cancer Research ,medicine.medical_specialty ,Genotype ,Taiwan ,Caspase 8 ,Polymorphism, Single Nucleotide ,Risk Assessment ,General Biochemistry, Genetics and Molecular Biology ,03 medical and health sciences ,0302 clinical medicine ,Gene Frequency ,Risk Factors ,Internal medicine ,Healthy control ,medicine ,Odds Ratio ,Humans ,Genetic Predisposition to Disease ,Patient group ,Allele frequency ,Alleles ,Aged ,Pharmacology ,business.industry ,Case-control study ,Variant allele ,Middle Aged ,030220 oncology & carcinogenesis ,Case-Control Studies ,Female ,Mouth Neoplasms ,business ,Cancer risk ,Research Article - Abstract
Background/Aim: Recently, mounting evidence has shown that caspase-8 (CASP8) rs3834129 (-652, 6N insertion/deletion) polymorphism may serve as a genetic biomarker for personal risk of various cancer types. The contribution of CASP8 rs3834129 polymorphism has been investigated in several oral cancer populations, but not in Taiwan. This study investigated the role of CASP8 rs3834129 polymorphism on oral risk in Taiwan. Materials and Methods: CASP8 rs3834129 polymorphic genotypes were determined and their associations with oral cancer risk were investigated among 788 patients with oral cancer and 956 age- and gender-matched healthy controls via polymerase chain reaction-restrictive fragment length polymorphism (PCR-RFLP) methodology. In addition, the interaction of CASP8 rs3834129 genotype with personal behavior and clinicopathological features were also examined. Results: The frequencies of II, ID and DD genotypes for CASP8 rs3834129 were 57.5, 36.5 and 6.0% in the patient group and 54.0, 39.0 and 7.0% in the healthy control group, respectively (p for trend=0.3052), genotypes were not significantly differentially distributed between the two groups. The comparisons in allelic frequency distribution also supported the findings that the D variant allele may not serve as a determinant of risk for oral cancer. There was no interaction of CASP8 rs3834129 genotype with age, gender, smoking, alcohol or betel quid consumption in regard to oral cancer risk. Conclusion: Our results indicate that the caspase-8 genotype does not appear to play a direct role in personal susceptibility to oral cancer in Taiwan.
- Published
- 2019