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4,621 results on '"Hu, Zhen"'

19. Association between BMI and osteoporotic fractures at different sites in Chinese women: a case-control retrospective study in Changsha

Author

Hong-Li Li, Yi Shen, Li-Hua Tan, Song-Bo Fu, Cong-Hui Guan, Dong-Hu Zhen, Hai-Hong Lv, Xi-Yu Wu, and Xu-Lei Tang

Subjects
BMI, Osteoporotic fracture, Fracture risk, Bone mineral density, Female, Diseases of the musculoskeletal system, RC925-935
Abstract

Abstract Background Osteoporotic fractures are a growing problem in an aging society. The association between body mass index (BMI) and osteoporotic fractures varies by fracture site and ethnicity. Limited knowledge exists regarding this association in native Chinese, particularly utilizing local databases as reference sources. Objective To investigate the association between BMI and osteoporotic fractures at different sites in Chinese women. Methods Three thousand ninety-eight female patients with radiographic fractures and 3098 age- and sex-matched healthy controls without fractures were included in the study. Both of them underwent assessment using dual-energy X-ray absorptiometry (DXA), with BMD measurements calculated using our own BMD reference database. Participants were classified into underweight (BMI < 18.5 kg/m2), normal weight (18.5 ≤ BMI < 24.0 kg/m2), overweight (24 ≤ BMI < 28 kg/m2) and obese (BMI ≥ 28 kg/m2) according to the Chinese BMI classification standard. Results There were 2296 (74.1%) vertebral fractures, 374 (12.1%) femoral neck fractures, and 428 (13.8%) other types of fractures in the case group. Bone mineral density (BMD) was almost lower in the fracture groups compared to the control groups (p = 0.048 to < 0.001). Compared with normal weight, underweight had a protective effect on total [odds ratio (OR) = 0.61; 95% confidence interval (CI), 0.49 –0.75; P< 0.001], and lumbar fractures (OR = 0.52; 95% CI, 0.41 – 0.67; P < 0.001), while obesity was associated with an increased risk for total (OR = 2.26; 95% CI, 1.85 – 2.76; P < 0.001), lumbar (OR = 2.17; 95% CI, 1.72 – 2.73; P < 0.001), and femoral neck fractures (OR = 4.08; 95% CI, 2.18 – 7.63; P < 0.001). Non-linear associations were observed between BMI and fractures: A J-curve for total, lumbar, and femoral neck fractures, and no statistical change for other types of fractures. Underweight was found to be a risk factor for other types of fracturess after adjusting for BMD (OR = 2.29; 95% CI, 1.09 – 4.80; P < 0.001). Osteoporosis and osteopenia were identified as risk factors for almost all sites of fracture when compared to normal bone mass. Conclusions Underweight has a protective effect on total and lumbar spine fractures in Chinese women, while obesity poses a risk factor for total, lumbar, and femoral neck fractures. The effect of BMI on fractures may be mainly mediated by BMD.

Published
2024
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20. Experimental Study on PCMI Behavior of RIA outside Reactor

Author

HAO Sijia, DING Xijia, HU Zhen, XU Qian, HAN Zhijie

Subjects
ria, pcmi, edc test, high speed camera technology, Nuclear engineering. Atomic power, TK9001-9401, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

The performance of zirconium alloy cladding has always been a concern during reactor accidents. Ensuring the safe operation of high fuel consumption under reactivity initiated accident condition is also the core issue that scholars from various countries pay common attention to. The United States, France, Japan, Russia and other countries have carried out a large number of tests under reactivity initiated accident conditions. Some countries have also carried out the most advanced biaxial loading tests outside reactors, which has laid a solid foundation for these countries to occupy a leading position in the field of nuclear fuel safety. At present, there was no experimental study on pellet cladding mechanical interaction (PCMI) failure mode in Reactivity initiated accident (RIA) research in China. In order to establish our own safety criteria for reactivity initiated accident operating conditions, it is urgent to carry out domestic independent reactivity insertion accident test research, so as to provide data support for the commercial application of advanced fuel components. PCMI failure of cladding under reactivity insertion accident condition is a typical failure mode of high burnup fuel. Exploring effective test methods and obtaining test data to analyze the mechanism of pellet-cladding mechanical interaction is necessary. In this paper, out-pile simulated cladding failure was studied. Out-pile test device simulated PCMI was designed and domestic Zr-4 cladding was chosen as test material. High speed camera technology was used to assist. Hydrogen content absorbed in test material was used to simulate different high burnup cladding mechanical properties. The data of load, strain and fracture during the failure process of biaxial loading fuel element cladding were obtained. The macroscopic morphology and residual strain of test materials were analyzed after tests and stress state and maximum circumferential strain data of cladding tube under out-pile simulated reactivity insertion accident condition were obtained. The comparison with foreign research data verifies the feasibility and reliability of the PCMI failure test technology under out-pile simulated reactivity insertion accident condition. The results show that the circumferential strain of cladding tube decreases slightly with the increase of hydrogen content, and the damage degree of cladding is intensified. The circumferential strain of cladding tube increases obviously with the increase of temperature, and the lower limit of residual strain ratio tends to increase. The results of residual strain ratio are between -0.1 and 0.5, which accords with the range of residual strain ratio in reactor. The research results provide technical reserve and experience accumulation for future tests. It also provide reference data for the safety standards.

Published
2024
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42. Effect of tocilizumab plus corticosteroid on clinical outcome in patients hospitalized with severe fever with thrombocytopenia syndrome: A randomized clinical trial

Author

Ge, Hong-Han, Cui, Ning, Yin, Xiao-Hong, Hu, Li-Fen, Wang, Zhi-You, Yuan, Yi-Mei, Yue, Ming, Lv, Hong-Di, Wang, Zhen, Zhang, Wen-Wen, Zhang, Lan, Yuan, Lan, Fan, Xue-Juan, Yang, Xin, Wu, Yong-Xiang, Si, Guang-Qian, Hu, Zhen-Yu, Li, Hao, Zhang, Xiao-Ai, Bao, Peng-Tao, and Liu, Wei

Published
2024
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