1. Local In Vivo Measures of Muscle Lipid and Oxygen Consumption Change in Response to Combined Vitamin D Repletion and Aerobic Training in Older Adults
- Author
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D. Travis Thomas, Hideat Abraha, Mingjun Zhao, Maja Redzic, Howard H. Brim, Guoqiang Yu, Danielle Jones, and David M. Schnell
- Subjects
Male ,0301 basic medicine ,Vitamin ,medicine.medical_specialty ,030209 endocrinology & metabolism ,vitamin D ,lcsh:TX341-641 ,Placebo ,Article ,vitamin D deficiency ,sarcopenia ,03 medical and health sciences ,chemistry.chemical_compound ,Oxygen Consumption ,0302 clinical medicine ,Internal medicine ,Vitamin D and neurology ,medicine ,Humans ,Aerobic exercise ,Treadmill ,skeletal muscle ,Muscle, Skeletal ,Exercise ,Aged ,metabolic function ,Nutrition and Dietetics ,IMCL ,business.industry ,Middle Aged ,Lipid Metabolism ,medicine.disease ,030104 developmental biology ,Endocrinology ,chemistry ,Sarcopenia ,Dietary Supplements ,Female ,business ,Cholecalciferol ,lcsh:Nutrition. Foods and food supply ,Food Science - Abstract
Intramyocellular (IMCL), extramyocellular lipid (EMCL), and vitamin D deficiency are associated with muscle metabolic dysfunction. This study compared the change in [IMCL]:[EMCL] following the combined treatment of vitamin D and aerobic training (DAT) compared with vitamin D (D), aerobic training (AT), and control (CTL). Male and female subjects aged 60&ndash, 80 years with a BMI ranging from 18.5&ndash, 34.9 and vitamin D status of &le, 32 ng/mL (25(OH)D) were recruited to randomized, prospective clinical trial double-blinded for supplement with a 2 ×, 2 factorial design. Cholecalciferol (Vitamin D3) (10,000 IU ×, 5 days/week) or placebo was provided for 13 weeks and treadmill aerobic training during week 13. Gastrocnemius IMCL and EMCL were measured with magnetic resonance spectroscopy (MRS) and MRI. Hybrid near-infrared diffuse correlation spectroscopy measured hemodynamics. Group differences in IMCL were observed when controlling for baseline IMCL (p = 0.049). DAT was the only group to reduce IMCL from baseline, while a mean increase was observed in all other groups combined (p = 0.008). IMCL reduction and the corresponding increase in rVO2 at study end (p = 0.011) were unique to DAT. Vitamin D, when combined with exercise, may potentiate the metabolic benefits of exercise by reducing IMCL and increasing tissue-level VO2 in healthy, older adults.
- Published
- 2019