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The Fornax galaxy cluster is the richest nearby (D ∼ 20 Mpc) galaxy association in the southern sky. As such, it provides a wealth of opportunities to elucidate on the processes where environment holds a key role in transforming galaxies. Although it has been the focus of many studies, Fornax has never been explored with contiguous homogeneous wide-field imaging in 12 photometric narrow and broad bands like those provided by the Southern Photometric Local Universe Survey (S-PLUS). In this paper, we present the S-PLUS Fornax Project (S+FP) that aims to comprehensively analyse the galaxy content of the Fornax cluster using S-PLUS. Our data set consists of 106 S-PLUS wide-field frames (FoV∼1.4 × 1.4 deg2) observed in five Sloan Digital Sky Survey-like ugriz broad bands and seven narrow bands covering specific spectroscopic features like [O  ii ], Ca  ii  H+K, Hδ, G band, Mg b triplet, Hα, and the Ca  ii triplet. Based on S-PLUS specific automated photometry, aimed at correctly detecting Fornax galaxies and globular clusters in S-PLUS images, our data set provides the community with catalogues containing homogeneous 12-band photometry for ∼3 × 106 resolved and unresolved objects within a region extending over ∼208 deg2 (∼5  R vir in RA) around Fornax' central galaxy, NGC 1399. We further explore the eagle and IllustrisTNG cosmological simulations to identify 45 Fornax-like clusters and generate mock images on all 12 S-PLUS bands of these structures down to galaxies with M ⋆ ≥ 108 M⊙. The S+FP data set we put forward in this first paper of a series will enable a variety of studies some of which are briefly presented. [ABSTRACT FROM AUTHOR]

We present the S-PLUS Transient Extension Program (STEP): a supernova and fast transient survey conducted in the southern hemisphere using data from the Southern Photometric Local Universe Survey (S-PLUS) Main Survey and the T80-South telescope. Transient astrophysical phenomena have a range of interest that goes through different fields of astrophysics and cosmology. With the detection of an electromagnetic counterpart to the gravitational wave (GW) event GW170817 from a binary neutron stars merger, new techniques and resources to study fast astrophysical transients in the multimessenger context have increased. In this paper, we present the STEP overview, the SN follow-up data obtained, data reduction, analysis of new transients and deep learning algorithms to optimize transient candidate selection. Additionally, we present prospects and optimized strategy for the search of gravitational wave counterparts in the current LIGO/Virgo/Kagra observational run (O4) in the context of T80-South telescope. [ABSTRACT FROM AUTHOR]

The Magellanic Clouds are the most massive and closest satellite galaxies of the Milky Way (MW), with stars covering ages from a few Myr up to 13 Gyr. This makes them important for validating integrated light methods to study stellar populations and star formation processes, which can be applied to more distant galaxies. We characterized a set of stellar clusters in the Small Magellanic Cloud (SMC), using the Southern Photometric Local Universe Survey. This is the first age (metallicity) determination for 11 (65) clusters of this sample. Through its seven narrow bands, centred on important spectral features, and five broad bands, we can retrieve detailed information about stellar populations. We obtained ages and metallicities for all stellar clusters using the Bayesian spectral energy distribution fitting code bagpipes. With a sample of clusters in the colour range −0.20 < r − z < +0.35, for which our determined parameters are most reliable, we modeled the age–metallicity relation of SMC. At any given age, the metallicities of SMC clusters are lower than those of both the Gaia Sausage-Enceladus disrupted dwarf galaxy and the MW. In comparison with literature values, differences are Δlog(age) ≈ 0.31 and Δ[Fe/H] ≈ 0.41, which is comparable to low-resolution spectroscopy of individual stars. Finally, we confirm a previously known gradient, with younger clusters in the centre and older ones preferentially located in the outermost regions. On the other hand, we found no evidence of a significant metallicity gradient. [ABSTRACT FROM AUTHOR]

We present tests of a new method to simultaneously estimate stellar population and emission-line (EL) properties of galaxies out of the Southern Photometric Local Universe Survey (S-PLUS) photometry. The technique uses the AlStar code, updated with an empirical prior that greatly improves its ability to estimate ELs using only the survey's 12 bands. The tests compare the output of (noise-perturbed) synthetic photometry of the Sloan Digital Sky Survey (SDSS) galaxies to properties derived from previous full spectral fitting and detailed EL analysis. For realistic signal-to-noise ratios, stellar population properties are recovered to better than 0.2 dex in masses, mean ages, metallicities, and ±0.2 mag for the extinction. More importantly, ELs are recovered remarkably well for a photometric survey. We obtain input − output dispersions of 0.05–0.2 dex for the equivalent widths of [O  ii ], [O  iii ], Hβ, Hα, [N  ii ], and [S  ii ], and even better for lines stronger than ∼5 Å. These excellent results are achieved by combining two empirical facts into a prior that restricts the EL space available for the fits. (1) Because, for the redshifts explored here, Hα and [N  ii ] fall in a single narrow band (J0660), their combined equivalent width is always well recovered, even when [N  ii ]/Hα is not. (2) We know from SDSS that |$W_{\mathrm{H}\alpha +[\mathrm{N}\,\small {\rm II}] }$| correlates with [N  ii ]/Hα, which can be used to tell if a galaxy belongs to the left or right wings in the classical Baldwin–Phillips–Telervich (BPT) diagnostic diagram. Example applications to integrated light and spatially resolved data are also presented, including a comparison with independent results obtained with the Multi-Unit Spectroscopic Explorer (MUSE)-based integral field spectroscopy. [ABSTRACT FROM AUTHOR]

The Southern Photometric Local Universe Survey (S-PLUS) is an ongoing survey of ∼9300 deg2 in the southern sky in a 12-band photometric system. This paper presents the second data release (DR2) of S-PLUS, consisting of 514 tiles covering an area of 950 deg2. The data has been fully calibrated using a new photometric calibration technique suitable for the new generation of wide-field multifilter surveys. This technique consists of a χ2 minimization to fit synthetic stellar templates to already calibrated data from other surveys, eliminating the need for standard stars and reducing the survey duration by ∼15 per cent. We compare the template-predicted and S-PLUS instrumental magnitudes to derive the photometric zero-points (ZPs). We show that these ZPs can be further refined by fitting the stellar templates to the 12 S-PLUS magnitudes, which better constrain the models by adding the narrow-band information. We use the STRIPE82 region to estimate ZP errors, which are ≲ 10 mmags for filters J0410, J0430, g , J0515, r , J0660, i , J0861 and z ; ≲ 15 mmags for filter J0378; and ≲ 25 mmags for filters u and J0395. We describe the complete data flow of the S-PLUS/DR2 from observations to the final catalogues and present a brief characterization of the data. We show that, for a minimum signal-to-noise threshold of 5, the photometric depths of the DR2 range from 19.1 to 20.5 mag (measured in Petrosian apertures), depending on the filter. The S-PLUS DR2 can be accessed from the website: https://splus.cloud. [ABSTRACT FROM AUTHOR]

This paper provides a catalogue of stars, quasars, and galaxies for the Southern Photometric Local Universe Survey Data Release 2 (S-PLUS DR2) in the Stripe 82 region. We show that a 12-band filter system (5 Sloan-like and 7 narrow bands) allows better performance for object classification than the usual analysis based solely on broad bands (regardless of infrared information). Moreover, we show that our classification is robust against missing values. Using spectroscopically confirmed sources retrieved from the Sloan Digital Sky Survey DR16 and DR14Q, we train a random forest classifier with the 12 S-PLUS magnitudes + 4 morphological features. A second random forest classifier is trained with the addition of the W1 (3.4  |$\mu\mathrm{m} $|⁠) and W2 (4.6  |$\mu\mathrm{m} $|⁠) magnitudes from the Wide-field Infrared Survey Explorer (WISE). Forty-four per cent of our catalogue have WISE counterparts and are provided with classification from both models. We achieve 95.76 per cent (52.47 per cent) of quasar purity, 95.88 per cent (92.24 per cent) of quasar completeness, 99.44 per cent (98.17 per cent) of star purity, 98.22 per cent (78.56 per cent) of star completeness, 98.04 per cent (81.39 per cent) of galaxy purity, and 98.8 per cent (85.37 per cent) of galaxy completeness for the first (second) classifier, for which the metrics were calculated on objects with (without) WISE counterpart. A total of 2926 787 objects that are not in our spectroscopic sample were labelled, obtaining 335 956 quasars, 1347 340 stars, and 1243 391 galaxies. From those, 7.4 per cent, 76.0 per cent, and 58.4 per cent were classified with probabilities above 80 per cent. The catalogue with classification and probabilities for Stripe 82 S-PLUS DR2 is available for download. [ABSTRACT FROM AUTHOR]

Basing our analysis on ROGUE I, a catalog of over 32,000 radio sources associated with optical galaxies, we provide two diagnostics to select the galaxies where the radio emission is dominated by an active galactic nucleus (AGN), referred to in the paper as radio-AGNs. Each of these diagnostics can be applied independently. The first one, dubbed MIRAD, compares the flux FW3 in the W3 mid-infrared band of the Wide-field Infrared Survey Explorer telescope, with the radio flux at 1.4 GHz, F1.4. MIRAD requires no optical spectra. The second diagnostic, dubbed DLM, compares the 4000 Å break strength, Dn(4000), with the radio luminosity per unit stellar mass. The DLM diagram has already been used in the past, but not as stand-alone. For these two diagrams, we propose simple, empirical dividing lines that result in the same classification for the objects in common. These lines correctly classify as radio-AGN 99.5% of the extended radio sources in the ROGUE I catalog, and as star-forming galaxies 98%–99% of the galaxies identified as such by their emission-line ratios. Both diagrams clearly show that radio-AGNs are preferentially found among elliptical galaxies and among galaxies hosting the most massive black holes. Most of the radio sources classified as radio-AGNs in the MIRAD or DLM diagrams are either optically weak AGNs or retired galaxies. [ABSTRACT FROM AUTHOR]

In this paper we present a thorough discussion about the photometric redshift (photo- z) performance of the Southern Photometric Local Universe Survey (S-PLUS). This survey combines a seven narrow +5 broad passband filter system, with a typical photometric-depth of r ∼ 21 AB. For this exercise, we utilize the Data Release 1 (DR1), corresponding to 336 deg2 from the Stripe-82 region. We rely on the BPZ2 code to compute our estimates, using a new library of SED models, which includes additional templates for quiescent galaxies. When compared to a spectroscopic redshift control sample of ∼100 k galaxies, we find a precision of σ z <0.8 per cent, <2.0 per cent, or <3.0 per cent for galaxies with magnitudes r < 17, <19, and <21, respectively. A precision of 0.6 per cent is attained for galaxies with the highest Odds values. These estimates have a negligible bias and a fraction of catastrophic outliers inferior to 1 per cent. We identify a redshift window (i.e. 0.26 < z < 0.32) where our estimates double their precision, due to the simultaneous detection of two emission lines in two distinct narrow bands; representing a window opportunity to conduct statistical studies such as luminosity functions. We forecast a total of ∼2 M, ∼16 M and ∼32 M galaxies in the S-PLUS survey with a photo-z precision of σ z <1.0 per cent, <2.0 per cent, and <2.5 per cent after observing 8000 deg2. We also derive redshift probability density functions, proving their reliability encoding redshift uncertainties and their potential recovering the n (z) of galaxies at z < 0.4, with an unprecedented precision for a photometric survey in the Southern hemisphere. [ABSTRACT FROM AUTHOR]

High extinction and crowding create a natural limitation for optical surveys towards the central regions of the Milky Way, where the gas and dust are mainly confined. Large-scale near-infrared (IR) surveys of the Galactic plane and bulge are a good opportunity to explore open scientific questions as well as to test our capability to explore future data sets efficiently. Thanks to the VISTA Variables in the Vía Láctea (VVV) ESO public survey, it is now possible to explore a large number of objects in those regions. This paper addresses the variability analysis of all VVV point sources having more than 10 observations in VVVDR4 using a novel approach. In total, the near-IR light curves of 288 378 769 sources were analysed using methods developed in the New Insight Into Time Series Analysis project. As a result, we present a complete sample having 44 998 752 variable star candidates (VVV-CVSC), which include accurate individual coordinates, near-IR magnitudes (Z,Y,J, and Hs), extinctions A (Ks), variability indices, periods, amplitudes, among other parameters to assess the science. Unfortunately, a side effect of having a highly complete sample, is also having a high level of contamination by non-variable (contamination ratio of non-variables to variables is slightly over 10:1). To deal with this, we also provide some flags and parameters that can be used by the community to decrease the number of variable candidates without heavily decreasing the completeness of the sample. In particular, we cross-identified 339 601 of our sources with Simbad and AAVSO data bases, which provide us with information for these objects at other wavelengths. This subsample constitutes a unique resource to study the corresponding near-IR variability of known sources as well as to assess the IR variability related with X-ray and gamma-ray sources. On the other hand, the other |${\sim }99.5{{\ \rm per\ cent}}$| sources in our sample constitutes a number of potentially new objects with variability information for the heavily crowded and reddened regions of the Galactic plane and bulge. The present results also provide an important queryable resource to perform variability analysis and to characterize ongoing and future surveys like TESS and LSST. [ABSTRACT FROM AUTHOR]

The Southern Photometric Local Universe Survey (S-PLUS) is imaging ∼9300 deg2 of the celestial sphere in 12 optical bands using a dedicated 0.8 m robotic telescope, the T80-South, at the Cerro Tololo Inter-american Observatory, Chile. The telescope is equipped with a 9.2k × 9.2k e2v detector with 10 |$\rm {\mu m}$| pixels, resulting in a field of view of 2 deg2 with a plate scale of 0.55 arcsec pixel−1. The survey consists of four main subfields, which include two non-contiguous fields at high Galactic latitudes (| b | > 30°, 8000 deg2) and two areas of the Galactic Disc and Bulge (for an additional 1300 deg2). S-PLUS uses the Javalambre 12-band magnitude system, which includes the 5 ugriz broad-band filters and 7 narrow-band filters centred on prominent stellar spectral features: the Balmer jump/[OII], Ca H + K, H δ, G band, Mg b triplet, H α, and the Ca triplet. S-PLUS delivers accurate photometric redshifts (δ z /(1 + z) = 0.02 or better) for galaxies with r < 19.7 AB mag and z < 0.4, thus producing a 3D map of the local Universe over a volume of more than |$1\, (\mathrm{Gpc}/h)^3$|⁠. The final S-PLUS catalogue will also enable the study of star formation and stellar populations in and around the Milky Way and nearby galaxies, as well as searches for quasars, variable sources, and low-metallicity stars. In this paper we introduce the main characteristics of the survey, illustrated with science verification data highlighting the unique capabilities of S-PLUS. We also present the first public data release of ∼336 deg2 of the Stripe 82 area, in 12 bands, to a limiting magnitude of r = 21, available at datalab.noao.edu/splus. [ABSTRACT FROM AUTHOR]

We combine data from the Sloan Digital Sky Survey (SDSS) and the Galaxy Evolution Explorer (GALEX) to simultaneously analyse optical spectra and ultraviolet photometry of 231 643 galaxies with the starlight spectral synthesis code using state-of-the-art stellar population models. We present a new method to estimate GALEX photometry in the SDSS spectroscopic aperture, which proves quite reliable if applied to large samples. In agreement with previous experiments with CALIFA, we find that adding UV constraints leads to a moderate increase on the fraction of ∼107–108 yr populations and a concomitant decrease of younger and older components, yielding slightly older luminosity-weighted mean stellar ages. These changes are most relevant in the low-mass end of the blue cloud. An increase in dust attenuation is observed for galaxies dominated by young stars. We investigate the contribution of different stellar populations to the fraction of light in GALEX and SDSS bands across the UV optical colour–magnitude diagram. As an example application, we use this λ dependence to highlight differences between retired galaxies with and without emission lines. In agreement with an independent study by Herpich et al. we find that the former shows an excess of intermediate-age populations when compared to the later. Finally, we test the suitability of two different prescription for dust, finding that our data set is best-fitting using the attenuation law of starburst galaxies. However, results for the Milky Way extinction curve improve with decreasing τV, especially for edge-on galaxies. [ABSTRACT FROM AUTHOR]

Early-type retired galaxies (RGs, i.e. galaxies which no longer form stars) can be divided into two classes: those with no emission lines, here dubbed lineless RGs, and those with emission lines, dubbed liny RGs. Both types of galaxies contain hot low-mass evolved stars (HOLMES) which emit ionizing photons. The difference must thus lie in the presence or absence of a reservoir of ionizable gas. From a volume-limited sample of 38 038 elliptical galaxies, we explore differences in physical properties between liny and lineless using data from the SDSS, WISE, and GALEX catalogues. To avoid biases in the comparison, we pair-match liny and lineless in stellar mass, redshift, and half-light Petrosian radius. We detect marginal differences in their optical stellar ages and NUV luminosities, indicating that liny RGs have an excess of intermediate-age (0.1–5 Gyr) stellar populations. Liny RGs show higher dust attenuation and W 3 luminosities than their lineless counterparts. We also find that the amount of warm gas needed to explain the observed Hα luminosity in liny RGs is 105–108M⊙, and that their [N ii ] /[O ii ] emission-line ratios are typical of those of the most massive star-forming galaxies. Taken together, these results rules out the following sources for the warm gas in liny RGs: mass-loss from intermediate-mass stars, mergers with metal-poor galaxies and intergalactic streams. They imply instead an inflow of enriched gas previously expelled from the galaxy or a merger with a metal-rich galaxy. The ionization source and the origin of the gas producing the emission lines are thus disconnected. [ABSTRACT FROM AUTHOR]

We use the Sloan Digital Sky Survey (SDSS) and Wide-field Sky Survey Explorer surveys to investigate the real nature of galaxies defined as low-ionization nuclear emission-line regions (LINERs) in the BPT diagram. After establishing a mid-infrared colour W2-W3 = 2.5 as the optimal separator between galaxies with and without star formation, we investigate the loci of different galaxy classes in the WHα versus W2-W3 space. We find that: (1) a large fraction of LINER-like galaxies are emission-line retired galaxies, i.e. galaxies which have stopped forming stars and are powered by hot low-mass evolved stars (HOLMES). Their W2-W3 colours show no sign of star formation and their Hα equivalent widths, WHα, are consistent with ionization by their old stellar populations. (2) Another important fraction have W2-W3 indicative of star formation. This includes objects located in the supposedly 'pure AGN' zone of the BPT diagram. (3) A smaller fraction of LINER-like galaxies have no trace of star formation from W2-W3 and a high WHα, pointing to the presence of an AGN. (4) Finally, a fewLINERs tagged as retired by theirWHα but withW2-W3 values indicative of star formation are late-type galaxies whose SDSS spectra cover only the old 'retired' bulge. This reinforces the view that LINER-like galaxies are a mixed bag of objects involving different physical phenomena and observational effects thrusted into the same locus of the BPT diagram. [ABSTRACT FROM AUTHOR]

The primary aim of this study was to investigate the impact of aerobic endurance training in schizophrenic inpatients on cognitive performance in a clinical routine setting. Of secondary interest was the influence on psychopathological symptoms. A total of 31 schizophrenic inpatients were randomly assigned to receive either controlled endurance training or occupational therapy. The experimental group underwent endurance training of 20-30 min each, 3 times per week for a total of up to 22 training sessions. The control group received about 90 min of occupational therapy, 2-3 times per week for up to 22 sessions. Cognitive performance was assessed via an extensive neuropsychological examination before randomization and prior to discharge. Significant improvements in cognitive functions and psychopathology could be shown in both groups. For verbal memory functions (short-term memory, working memory, and learning performance), there was a significant advantage for the aerobic endurance training group. Physical exercise is a feasible, easy-to-implement add-on therapy for schizophrenic patients in a clinical routine setting with positive effects on verbal memory functions. Besides, it seems important to fill the gap between inpatient and outpatient health care, providing physical training supply for this patient group., (© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany.)

Background: Mobility is important for daily life functioning, with particular challenges regarding road safety under pharmacological treatment in patients with a psychiatric disease., Methods: According to PRISMA guidelines, a systematic literature search on PubMed database (January 1970 to December 2020) was performed. Primary endpoints were driving performance in on-road tests, driving simulator performance, or psychomotor and visual perception functions assessed to estimate fitness to drive according to legal regulations in patient studies., Results: Forty studies were identified (1533 patients, 38% female, median age 45 years), of which more than 60% were cross-sectional and open-label trials. Under steady-state medication, 31% (range 27%-42.5%) of schizophrenic or schizoaffective patients under antipsychotics and 18% (range 16%-20%) of unipolar and bipolar patients under antidepressants showed severe impairment in skills relevant for driving. Data point to an advantage of second-generation antipsychotics compared with first-generation antipsychotics as well as modern antidepressants over tricyclic antidepressants with respect to driving. Most patients significantly improved or stabilized in driving skills within 2-4 weeks of treatment with non-sedative or sedative antidepressants. Diazepam significantly worsened driving the first 3 weeks after treatment initiation, whereas medazepam (low dose), temazepam, and zolpidem did not impair driving. In long-term users of sedating antidepressants or benzodiazepines, impairments in on-road tests were not evident., Conclusion: The available evidence suggests that psychopharmacologic medicines improve or at least stabilize driving performance of patients under long-term treatment when given on clinical considerations. To enhance treatment compliance, existing classification systems of medicinal drugs concerning impact on driving performance should also incorporate information about effects of long-term-treatment., (© The Author(s) 2021. Published by Oxford University Press on behalf of CINP.)

Introduction: Due to aging and health status people may be subjected to a decrease of cognitive ability and subsequently also a decline of driving safety. On the other hand there is a lack of valid and economically applicable instruments to assess driving performance., Objective: The study is designed to develop a valid screening-tool for fitness-to-drive assessment in older people with cognitive impairment externally validated on the basis of on-road driving performance., Methods: In a single-centre, non-randomized cross-sectional trial cognitive functioning and on-road-driving-behavior of older drivers will be assessed. Forty participants with cognitive impairment of different etiology and 40 healthy controls will undergo an extensive neuropsychological assessment. Additionally, an on-road driving assessment for external validation of fitness to drive will be carried out. Primary outcome measures will be performance in attention, executive functions and visuospatial tasks that will be validated with respect to performance on the on-road-driving-test. Secondary outcome measures will be sociodemographic, clinical- and driving characteristics to systematically examine their influence on the prediction of driving behavior., Discussion: In clinical practice counselling patients with respect to driving safety is of great relevance. Thus, having valid, reliable, time economical and easily interpretable screening-tools on hand to counsel patients is of great relevance for practitioners., Ethics and Dissemination: Ethics approval was obtained from the Ethics Committee at the Ludwig-Maximilians-University Munich. The trial results will be disseminated through peer-reviewed publications and various conferences., Trial Registration: 18-640. Trial registration: German Clinical Trials Register. Registration number: DRKS00023549., Competing Interests: Brieber and Herle work at the Schuhfried GmbH, who funded the present study. The other authors declare that the research will be conducted in absence of any commercial or financial relationships that could be interpreted as a potential conflict of interest.

Objectives: Concise "synthetic" review of the state of the art of management of acute ischemic stroke., Data Sources: Available literature on PubMed., Study Selection: We selected landmark studies, recent clinical trials, observational studies, and professional guidelines on the management of stroke including the last 10 years., Data Extraction: Eligible studies were identified and results leading to guideline recommendations were summarized., Data Synthesis: Stroke mortality has been declining over the past 6 decades, and as a result, stroke has fallen from the second to the fifth leading cause of death in the United States. This trend may follow recent advances in the management of stroke, which highlight the importance of early recognition and early revascularization. Recent studies have shown that early recognition, emergency interventional treatment of acute ischemic stroke, and treatment in dedicated stroke centers can significantly reduce stroke-related morbidity and mortality. However, stroke remains the second leading cause of death worldwide and the number one cause for acquired long-term disability, resulting in a global annual economic burden., Conclusions: Appropriate treatment of ischemic stroke is essential in the reduction of mortality and morbidity. Management of stroke involves a multidisciplinary approach that starts and extends beyond hospital admission.

Background and Purpose: Coronavirus disease 2019 (COVID-19) is a global pandemic that causes flu-like symptoms. There is a growing body of evidence suggesting that both the central and peripheral nervous systems can be affected by SARS-CoV-2, including stroke. We present three cases of arterial ischemic strokes and one venous infarction from a cerebral venous sinus thrombosis in the setting of COVID-19 infection who otherwise had low risk factors for stroke., Methods: We retrospectively reviewed patients presenting to a large tertiary care academic US hospital with stroke and who tested positive for COVID-19. Medical records were reviewed for demographics, imaging results and lab findings., Results: There were 3 cases of arterial ischemic strokes and 1 case of venous stroke: 3 males and 1 female. The mean age was 55 (48-70) years. All arterial strokes presented with large vessel occlusions and had mechanical thrombectomy performed. Two cases presented with stroke despite being on full anticoagulation., Conclusions: It is important to recognize the neurological manifestations of COVID-19, especially ischemic stroke, either arterial or venous in nature. Hypercoagulability and the cytokine surge are perhaps the cause of ischemic stroke in these patients. Further studies are needed to understand the role of anticoagulation in these patients., (Copyright © 2020 Elsevier Ltd. All rights reserved.)

Numerous behavioral studies have shown that visual function can improve with training, although perceptual refinements generally require weeks to months of training to attain. This, along with questions about long-term retention of learning, limits practical and clinical applications of many such paradigms. Here, we show for the first time in female and male human participants that just 10 d of visual training coupled with transcranial random noise stimulation (tRNS) over visual areas causes dramatic improvements in visual motion perception. Relative to control conditions and anodal stimulation, tRNS-enhanced learning was at least twice as fast, and, crucially, it persisted for 6 months after the end of training and stimulation. Notably, tRNS also boosted learning in patients with chronic cortical blindness, leading to recovery of motion processing in the blind field after just 10 d of training, a period too short to elicit enhancements with training alone. In sum, our results reveal a remarkable enhancement of the capacity for long-lasting plastic and restorative changes when a neuromodulatory intervention is coupled with visual training. SIGNIFICANCE STATEMENT Our work demonstrates that visual training coupled with brain stimulation can dramatically reduce the training period from months to weeks, and lead to fast improvement in neurotypical subjects and chronic cortically blind patients, indicating the potential of our procedure to help restore damaged visual abilities for currently untreatable visual dysfunctions. Together, these results indicate the critical role of early visual areas in perceptual learning and reveal its capacity for long-lasting plastic changes promoted by neuromodulatory intervention., (Copyright © 2019 the authors.)

Non-invasive brain stimulation safely induces persistent large-scale neural modulation in functionally connected brain circuits. Interruption models of repetitive transcranial magnetic stimulation (rTMS) capitalize on the acute impact of brain stimulation, which decays over minutes. However, rTMS also induces longer-lasting impact on cortical functions, evident by the use of multi-session rTMS in clinical population for therapeutic purposes. Defining the persistent cortical dynamics induced by rTMS is complicated by the complex balance of excitation and inhibition among functionally connected networks. Nonetheless, it is these neuronal dynamic responses that are essential for the development of new neuromodulatory protocols for translational applications. We will review evidence of prolonged changes of cortical response, tens of minutes following one session of low frequency rTMS over the cortex. We will focus on the different methods which resulted in prolonged behavioral and brain changes, such as the combination of brain stimulation techniques, and individually tailored stimulation protocols. We will also highlight studies which apply these methods in multi-session stimulation practices to extend stimulation impact into weeks and months. Our data and others' indicate that delayed cortical dynamics may persist much longer than previously thought and have potential as an extended temporal window during which cortical plasticity may be enhanced.

Background: Transcranial random noise stimulation (tRNS) can cause long term increase of corticospinal excitability when used to prime the motor cortex, before measuring the motor response in the hand muscles with TMS (Terney et al., 2008). In cognitive studies, tRNS has been used to improve visual attention and mathematical skills, an enhancement effect that might suggest sustained cortical plasticity changes (Cappelletti et al., 2013; Snowball et al., 2013). However, while the behavioral evidence of increased performance is becoming substantiated by empirical data, it still remains unclear whether tRNS over visual areas causes an increase in cortical excitability similar to what has been found in the motor cortex, and if that increase could be a potential physiological explanation for behavioral improvements found in visual tasks., Objective/hypothesis: In the present study, we aimed to investigate whether priming the visual cortex with tRNS leads to increased and sustained excitability as measured with visual phosphenes., Methods: We measured phosphene thresholds (PTs) using an objective staircase method to quantify the magnitude of cortical excitability changes. Single-pulse TMS was used to elicit phosphenes before, immediately after, and every 10 min up to one hour after the end of 20 min tRNS, anodal tDCS (a-tDCS) or sham., Results: Results showed that phosphene thresholds were significantly reduced up to 60 min post stimulation relative to baseline after tRNS, a behavioral marker of increased excitability of the visual cortex, while a-tDCS had no effect. This result is very similar in magnitude and duration to what has been found in the motor cortex., Conclusions: Our findings demonstrate promising potential of tRNS as a tool to increase and sustain cortical excitability to promote improvement of cognitive functions., (Copyright © 2018 Elsevier Ltd. All rights reserved.)

Patients affected by right parietal lobe lesion can be severely impaired in sustained attention tasks, particularly in the left visual field. For example, patients with right parietal stroke are commonly limited in their ability to attentionally track multiple moving objects in their left visual field when competing stimuli are simultaneously presented in the right, ipsilesional visual field. This is a hallmark of visual extinction, a failure to respond to contralesional visual stimuli, when competing stimuli are presented in the good hemifield. It has been hypothesized that post-stroke hyperactivity of the undamaged left hemisphere leads to excessive cross-hemispheric inhibition of the damaged right hemisphere, thus exacerbating the attentional deficits. However, there has been no direct physiological demonstration of this hypothesis, as most of the studies are conducted using unilateral tasks, a condition not sufficient to drive inter-hemispheric competition. The inter-hemispheric inhibition hypothesis also raises the possibility that if hyperactivity of the healthy hemisphere were reduced, this could relieve inter-hemispheric inhibition, disinhibiting the damaged hemisphere and potentially restoring some function. To test this hypothesis, and to examine whether we could relieve deficits in sustained attention in right parietal patients, we used repetitive transcranial magnetic stimulation (rTMS) to reduce the activity of the left, healthy hemisphere. Six patients suffering from visual extinction underwent two counterbalanced sessions: low frequency rTMS over the left parietal lobe and sham control stimulation. The patients' performance in an attentional tracking task significantly improved in the contralesional visual field immediately after rTMS, but not after sham. Performance remained unaltered in the ipsilesional field. We hypothesize that rTMS temporarily releases the damaged right hemisphere from excessive cross-hemispheric inhibition by the hyperactive healthy hemisphere, leading to some cognitive recovery after cortical lesion., (Copyright © 2014 Elsevier Ltd. All rights reserved.)